KR20020068053A - 양쪽친화성 폴리머와 이를 포함하는 폴리펩티드 접합체 - Google Patents

양쪽친화성 폴리머와 이를 포함하는 폴리펩티드 접합체 Download PDF

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Publication number
KR20020068053A
KR20020068053A KR1020027007500A KR20027007500A KR20020068053A KR 20020068053 A KR20020068053 A KR 20020068053A KR 1020027007500 A KR1020027007500 A KR 1020027007500A KR 20027007500 A KR20027007500 A KR 20027007500A KR 20020068053 A KR20020068053 A KR 20020068053A
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KR
South Korea
Prior art keywords
lcrf
moiety
polymer
complex
group
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Application number
KR1020027007500A
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English (en)
Korean (ko)
Inventor
익크유리브녹키리엔.
Original Assignee
노벡스 코포레이션
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Application filed by 노벡스 코포레이션 filed Critical 노벡스 코포레이션
Publication of KR20020068053A publication Critical patent/KR20020068053A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
KR1020027007500A 1999-12-13 2000-12-11 양쪽친화성 폴리머와 이를 포함하는 폴리펩티드 접합체 KR20020068053A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/459,443 1999-12-13
US09/459,443 US6638906B1 (en) 1999-12-13 1999-12-13 Amphiphilic polymers and polypeptide conjugates comprising same
PCT/US2000/033592 WO2001041812A2 (en) 1999-12-13 2000-12-11 Amphiphilic polymers and polypeptide conjugates comprising same

Publications (1)

Publication Number Publication Date
KR20020068053A true KR20020068053A (ko) 2002-08-24

Family

ID=23824795

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027007500A KR20020068053A (ko) 1999-12-13 2000-12-11 양쪽친화성 폴리머와 이를 포함하는 폴리펩티드 접합체

Country Status (18)

Country Link
US (2) US6638906B1 (US06638906-20031028-C00021.png)
EP (1) EP1237580A2 (US06638906-20031028-C00021.png)
JP (1) JP2003516366A (US06638906-20031028-C00021.png)
KR (1) KR20020068053A (US06638906-20031028-C00021.png)
CN (1) CN1434725A (US06638906-20031028-C00021.png)
AU (1) AU2087501A (US06638906-20031028-C00021.png)
BR (1) BR0016339A (US06638906-20031028-C00021.png)
CA (1) CA2394928A1 (US06638906-20031028-C00021.png)
CZ (1) CZ20021990A3 (US06638906-20031028-C00021.png)
HK (1) HK1049283A1 (US06638906-20031028-C00021.png)
HU (1) HUP0300133A2 (US06638906-20031028-C00021.png)
IL (1) IL150119A0 (US06638906-20031028-C00021.png)
MX (1) MXPA02005885A (US06638906-20031028-C00021.png)
NO (1) NO20022793L (US06638906-20031028-C00021.png)
PL (1) PL359174A1 (US06638906-20031028-C00021.png)
RU (1) RU2002118709A (US06638906-20031028-C00021.png)
WO (1) WO2001041812A2 (US06638906-20031028-C00021.png)
ZA (1) ZA200204603B (US06638906-20031028-C00021.png)

Cited By (1)

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WO2024043632A1 (ko) * 2022-08-22 2024-02-29 부산대학교 산학협력단 폴리소르베이트-숙신산-카르니틴 복합체 및 이를 포함하는 생리활성 물질 또는 약물 전달용 조성물

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US6703381B1 (en) * 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US20090281023A9 (en) * 2001-06-04 2009-11-12 Nobex Corporation Mixtures Of Calcitonin Drug-Oligomer Conjugates And Methods Of Use In Pain Treatment
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
AU2003202026A1 (en) 2002-01-16 2003-09-02 Dynal Biotech Asa Method for isolating nucleic acids and protein from a single sample
US20040062748A1 (en) * 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US7648962B2 (en) * 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
AU2003297583B2 (en) * 2002-11-26 2010-01-14 Biocon, Ltd Modified naturetic compounds, conjugates, and uses thereof
GB0229287D0 (en) * 2002-12-16 2003-01-22 Dna Res Innovations Ltd Polyfunctional reagents
CN1761680A (zh) 2002-12-26 2006-04-19 武田药品工业株式会社 肿瘤迁移抑制素衍生物及其用途
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
AU2004285558A1 (en) * 2003-10-29 2005-05-12 Altus Pharmaceuticals Inc. Non-pancreatic proteases for controlling plasma cholecystokinin (CCK) concentration and for treating pain
SG153865A1 (en) 2004-06-25 2009-07-29 Takeda Pharmaceutical Metastin derivatives and use thereof
US8329958B2 (en) 2004-07-02 2012-12-11 Biocon Limited Combinatorial synthesis of PEG oligomer libraries
US8168222B2 (en) * 2004-09-07 2012-05-01 Board Of Regents Of The University Of Nebraska Amphiphilic polymer-protein conjugates and methods of use thereof
WO2006076471A2 (en) * 2005-01-12 2006-07-20 Nobex Corporation Bnp conjugates and methods of use
CA2606270A1 (en) * 2005-04-19 2006-10-26 Massachusetts Institute Of Technology Amphiphilic polymers and methods of use thereof
WO2007011959A2 (en) * 2005-07-15 2007-01-25 Quintessence Biosciences, Inc. Methods and compositions for extracting membrane proteins
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
JO3048B1 (ar) 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
EP2314609B1 (en) * 2008-07-30 2016-11-30 Takeda Pharmaceutical Company Limited Metastin derivative and use thereof
RU2013141079A (ru) * 2011-03-01 2015-04-10 Ново Нордиск А/С Антагонические лиганды dr3
CN103740661B (zh) * 2012-05-10 2015-06-03 江南大学 一种提高酶热稳定性的方法
CN103740659B (zh) * 2012-05-10 2015-06-03 江南大学 一种提高酶热稳定性的方法
US20140039158A1 (en) * 2012-07-25 2014-02-06 Belrose Pharma, Inc. Polymeric conjugates and methods of preparing the same
CN106729735B (zh) * 2017-03-09 2020-05-12 国家纳米科学中心 一种pH敏感的多肽聚合物及其制备方法和应用
JP2021521231A (ja) * 2018-04-16 2021-08-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 熱安定性を改善するためのタンパク質製剤のための添加剤

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US6495514B1 (en) * 1998-01-21 2002-12-17 Mercer University Method for reducing inflammation and inducing an analgesic effect and compounds thereof
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
KR100345214B1 (ko) * 1999-08-17 2002-07-25 이강춘 생체적합성 고분자가 수식된 펩타이드의 비점막 전달
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024043632A1 (ko) * 2022-08-22 2024-02-29 부산대학교 산학협력단 폴리소르베이트-숙신산-카르니틴 복합체 및 이를 포함하는 생리활성 물질 또는 약물 전달용 조성물

Also Published As

Publication number Publication date
MXPA02005885A (es) 2002-10-23
IL150119A0 (en) 2002-12-01
US6638906B1 (en) 2003-10-28
NO20022793D0 (no) 2002-06-12
HK1049283A1 (zh) 2003-05-09
CA2394928A1 (en) 2001-06-14
EP1237580A2 (en) 2002-09-11
WO2001041812A2 (en) 2001-06-14
RU2002118709A (ru) 2004-02-27
NO20022793L (no) 2002-08-13
CZ20021990A3 (cs) 2002-11-13
HUP0300133A2 (en) 2003-05-28
WO2001041812A3 (en) 2002-03-21
CN1434725A (zh) 2003-08-06
AU2087501A (en) 2001-06-18
PL359174A1 (en) 2004-08-23
BR0016339A (pt) 2002-08-27
US20040092449A1 (en) 2004-05-13
ZA200204603B (en) 2003-11-26
JP2003516366A (ja) 2003-05-13

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