KR20020029232A - Enteral formula suppressing the occurrence of the odor of stool and diarrhea - Google Patents

Abstract

PURPOSE: An enteral nutritional product containing an Agaricus bisporus extract and a fructan fiber is provided which can remove fecal odor and prevent diarrhea and can be used as special nutritious foods for a patient of renal failure, kidney disease, chronic hepatic disease, diabetes or gastrointestinal disorders. CONSTITUTION: This enteral nutritional product contains a hydrophilic solvent extract of fresh of Agaricus bisporus and fructan as a water-soluble dietary fiber. The product is a power or liquid form, wherein in the case of a powder form, the product contains 0.1 to 0.4g hydrophilic solvent extract of fresh of Agaricus bisporus and 2.5 to 8g fructan per 100g respectively, in the case of a liquid form, the product contains 0. to 0.4g hydrophilic solvent extract of fresh of Agaricus bisporus and 2.5 to 8g fructan per 100g respectively.

Description

Enteral culture for suppressing diarrhea and fecal odor {ENTERAL FORMULA SUPPRESSING THE OCCURRENCE OF THE ODOR OF STOOL AND DIARRHEA}

The present invention provides an enteral diet comprising hydrophilic solvent extracts of fructose and fructan fiber in order to prevent or minimize the occurrence of fecal odor and diarrhea when ingested enteric nutrition. In particular, the present invention relates to special nutritional supplements or dietary supplements for patients, such as nutritional supplements for patients with renal failure, kidney disease, chronic liver disease, diabetes or digestive disease.

In general, the patient food is classified as a special nutritional food at the Korea Food Fair and is mainly manufactured and used for oral or landscape feeding. Conventionally, nutritional formula for patients has been focused on satisfying the nutritional requirements of patients by adjusting the content of nutrients related to diseases of specific patients, as described in Korean Patent Publication No. 97-005903. The function of inhibiting or inhibiting the occurrence of fecal odor has not been considered.

In particular, the occurrence of diarrhea is a very frequent side effect of oral or cervical feeding patients by the administration of various antibiotics, especially in the cervical feeding patients, diarrhea may cause skin damage around the anus. In the case of neurosurgery patients who have been hospitalized for a long time, the patient has no consciousness of himself and must receive other people's food intake and treatment of urine and urine. However, the occurrence of fecal odor and body odor can cause a lot of inconvenience for the caregiver of the patient. Such fecal odor occurs more strongly when a high protein diet is consumed, such as after recovery from surgery.

In order to solve these problems, the inventors of the present invention have studied to solve the problems occurring in the existing technology, and as a result of considering the physiological characteristics of patients or the elderly using the enteric culture as well as better nutrition than the existing enteral culture, Was completed.

The present invention provides an enteric diet comprising hydrophilic solvent extract and fructan fiber of Agaricus bisporus flesh to prevent fecal odor and prevent diarrhea and to provide nutritionally superior liquid or powder enteric diet. To provide.

Another object of the present invention is to provide an enteric diet comprising hydrophilic solvent extracts of Agaricus bisporus flesh and fructan fiber to prevent fecal odor and prevent diarrhea, It is to provide special nutritional supplements or health supplements for patients, such as nutritional foods for patients with kidney failure, kidney disease, chronic liver disease, diabetes or digestive disease.

The present invention provides an enteral diet comprising a hydrophilic solvent extract of fructose (Agaricus bisporus) flesh and fructan fiber in order to prevent or minimize the occurrence of fecal odor and diarrhea when ingested enteric nutrition. In particular, it relates to cervical feeding and special nutritional products for patients such as renal failure patients, kidney disease patients, chronic liver disease patients, diabetes patients or nutritional foods for digestive diseases.

Enteral culture of the present invention is provided as a powder may be ingested by direct hydrolysis, or may be provided in liquid form.

The present invention is a product that can minimize the occurrence of diarrhea and fecal odor is the most problematic side effects for special nutritional foods and specific foods to be oral or landscape feeding. The fructan fiber used in the present invention is to prevent the occurrence of diarrhea and constipation. Diarrhea and constipation occur frequently in the existing products, especially in the case of patient type, the patient has low exercise volume, and it occurs very frequently in the oral and cervical feeding patients by the administration of various kinds of antibiotics. Diarrhea may cause skin damage around the anus.

This problem can be prevented by taking 4-35g of fructan dietary fiber per day. In case of powdered enteral culture, fructan dietary fiber contains 2.5g to 8g per 100g, in case of liquid enteral culture, it contains 0.6g to 2g per 100ml and fructane dietary fiber contains 0.04g to 0.016g per 100ml It is preferable.

The fructan dietary fiber which can impart such a property is a water-soluble dietary fiber derived from inulin, and a polymerization degree of about 2-60 is appropriate. The fructan dietary fiber of the present invention does not hydrolyze well by human digestive tract digestive enzymes and reaches the large intestine, thereby selectively increasing the number of Bifidobacteria bacteria, which are beneficial lactic acid bacteria at relatively low levels. Bouhnik et al., Gasteroenterology. 106: A598, 1994; Buddington et al., Am. J. Clin. Nutr. 63: 709, 1996; Gibson et al., Gastroenterology. 108: 975, 1995; Kleessen et al., Am. J. Clin. Nutr. 65: 1397, 1997; Mitsuoka et al., Die Nahrung 31: 426, 1987; Williams et al., Microb. Ecol. Health Dis. 7:91, 1994). In addition, improvements in the frequency of bowel movements and stiffness of stool were evident (Sobata et al., Nutrition. 13:21, 1997). This effect is reported to be due to the decrease in the water content of feces by short-chain fatty acids produced by the decomposition of fructan dietary fiber by lactic acid bacteria (Bowling et al., Lancet. 342: 1266, 1993; Sobata et al., Nutrition. 13:21, 1997).

The fructan dietary fiber of 60 in the polymerization degree 2 used by this invention has the following characteristics compared with other water-soluble dietary fiber. In other words, it shortens the intestinal transit time of digestive products and improves bowel motility to increase the number of bowel movements and to improve diarrhea (Kleessen et al., Am. J. Clin. Nutr. 65: 1397, 1997). Selectively promotes the growth of a beneficial microorganism, Bifidobacteria, to prevent diarrhea that can be caused by the suppression of beneficial intestinal microbial growth by antibiotic administration (Gibson et al., Gastroenterology 108: 975, 1995); Gibson and Robert, J. Nutr. 125: 1401, 1995), which breaks up the fructan dietary fiber in the large intestine, increasing the production of short-chain fatty acids and lactic acid, thereby facilitating the absorption of minerals such as calcium, magnesium, iron and zinc in the large intestine (Coudray et al., Eur. J. Clin. Nutr. 51: 375, 1997), the ionization of minerals in the large intestine forms salts with bile acids or fatty acids to prevent damage to colon cells by bile acids and short-chain fatty acids (Coudray et al., Eur. J. Clin. Nutr). 51: 375, 1997).

In addition, in the present invention, the hydrophilic solvent extract (champion name: Agaricus bisporus) of the mushroom (champignon mushroom) flesh for the prevention and suppression of the generation of feces.

Fecal odor generation inhibitor in the present invention is a hydrophilic solvent extract of Matsutake mushroom also called Bio-M (trade name, Japan Ricom Co.) or Champignion and the amount of 0.5 to 2.0 g per day depending on the content of Matsutake extract do. In the case of powder enteral culture, the hydrophilic solvent extract (Bio-M) of the pine mushroom flesh is preferably contained in 0.1 to 0.4 g per 100 g, and in the case of liquid enteral culture, it contains 0.6 g to 2 g per 100 ml.

In order to test the effect of bio-M fecal odor on humans, ingestion of 0.5 to 2.0 g per day depending on the content of pine mushroom extract resulted in a rapid increase in the contents of ammonia, methylmercaptan, methylamine and hydrogen sulfide in feces. At the same time, it has been reported that the concentration of ammonia in blood could also be lowered (浜 屋 忠 生. 食品 と 開發. 30:41, 1995; 何 部 二 郞. 弟 36 回, 1995 表 內容, 1995).

Therefore, in the present invention, to minimize the generation of fecal odor of the patient to provide information on the preparation of enteral diet containing 0.5 to 2.0g Bio-M powder.

The deodorant mechanism of pine mushroom extract can be divided into three types according to the digestive organs, and since it has a function of preventing the odor appearing in the body, it is almost the same effect even when the enteric diet containing a certain amount of these ingredients is ingested.

First, odors in the oral cavity, esophagus, stomach, and small intestine may be affected by methyl mercaptan and the digestion of proteins by bacteria in the oral cavity, by enzymes in food, and by digestive enzymes in the oral cavity, stomach, and small intestine. Volatile sulfur compounds such as hydrogen sulfide are generated. Odor suppression mechanisms occurring in the oral cavity, esophagus, stomach and small intestine of the mushroom hydrophilic extract are changed to non-volatile volatile sulfur compounds by addition reactions of various types of polyphenols to remove odor components. Second, about 100 types of feces and digestions occur in the large intestine such as methyl mercaptan, dimethyl sulfide, ammonia, amine and hydrogen sulfide by proteolysis by metabolites of intestinal bacteria and enzymes contained in undigested nutrients. Is caused by volatile sulfur compounds. As a result of clinical trials in humans, it was confirmed that the pine mushroom flesh hydrophilic solvent extract lowers the incidence of fecal odor by inhibiting the production of metabolites in the large intestine (何 部 二 郞. 弟 36 回 東北 臨 床 衛生 檢査 學會發表 內容, 1995).

Third, the occurrence of odor through breathing occurs when the odor component in the large intestine is absorbed into the blood from the intestine and then discharged into the mouth. The mechanism of eliminating malodor is not absorbed into the blood from the intestine by suppressing the concentration of malodorous components in the large intestine.

The enteral nutrition of the present invention relates to the development of special nutritional products, such as nutritional foods for patients such as kidney failure, kidney disease, chronic liver disease, diabetic or digestive disease, as well as nutritional characteristics of the product for each disease Rather, it is to develop an enteral diet that can prevent the occurrence of diarrhea and remove odors, including fecal odor, to improve the quality of life of patients.

1) Powder General Entering Culture

Casein or sodium caseinate and enzymatic casein hydrolysate, 17.17 g, dextrin 46.1 g, sugar 15.0 g, fructan dietary fiber 6.45 g, jade oil 10.58 g, MCT oil 2.64 g , 0.3g soy lecithin and 0.133g Bio-M dissolved in purified water and added to the vitamins and minerals of Table 1 to sterilize, homogenize, concentrate and spray dry to fully satisfy the nutritional needs of the general public and the nutritional requirements of patients. Prepare enteric culture.

Vitamin and Mineral Blending Ratio of Powdered General Enteral Culture (%) Name usage Potassium citrate 0.52 Sodium citrate 1.25 Magnesium chloride 0.8 Potassium chloride 0.45 Dicalcium Phosphate 1.10 Zinc sulfate 0.023 Copper sulfate 0.00175 Ferrous sulfate 0.022 Dibasic Potassium Phosphate 0.11 Manganese sulfate 0.0031 Potassium Iodine 0.000065 Vitamin A palmitate 0.004 Vitamin B1 0.0012 Vitamin B2 0.0012 Vitamin B6 0.00183 Vitamin B12 0.0000045 Vitamin c 0.2135 Vitamin D3 0.0011 Vitamin E 0.048 Vitamin K 0.0014 Calcium Pantothenate 0.0035 Niacin 0.0105 Folic acid 0.00013 Biotin 0.00008 Choline chloride 0.0014

Casein or sodium caseinate and enzymatic casein hydrolysate, 12.02 g, soy protein or soy protein isolate 5.15 g, dextrin 46.1 g, sugar 15.0 g, fructan dietary fiber 6.45 g, jade oil 10.58 g , MCT oil 2.64g, soy lecithin 0.3g, Bio-M 0.133g dissolved in purified water and then added vitamins and minerals of Table 2 as sterilization, homogeneous, concentrated, spray-drying as the main raw material as shown in Table 1 as an additive By mixing, homogenizing, condensing and spray-drying to prepare a powder enteric diet that can fully satisfy the nutritional needs of the general public and the nutritional requirements of patients.

2) Liquid Enteral Culture

Milk protein (Kysine or Casein Sodium and Kesin Hydrolysates), vegetable protein (Isolated Soy Protein or Soy Protein Isolate) can be a single protein source or 4.3% mixture of milk protein and vegetable protein 70:30, Dextrin 11.53%, Sugar 3.75 %, Fructan dietary fiber 1.61%, jade oil 2.65%, MCT oil 0.66%, soy lecithin 0.1%, Bio-M 0.04% dissolved in purified water to adjust the final amount to 100ml and then vitamins and minerals as shown in Table 2 To add a homogeneous, packaged, retort sterilized or sterilized to prepare a liquid entertaining diet that can fully meet the nutritional needs of the general public and the nutritional requirements of patients.

Vitamin and Mineral Blending Ratio of Liquid Normal Enteral Culture Name usage(%) Potassium citrate 0.13 Sodium citrate 0.31 Magnesium chloride 0.20 Potassium chloride 0.11 Dicalcium Phosphate 0.28 Zinc sulfate 0.006 Copper sulfate 0.00044 Ferrous sulfate 0.0055 Dibasic Potassium Phosphate 0.028 Manganese sulfate 0.00078 Potassium Iodine 0.0000163 Vitamin A palmitate 0.001 Vitamin B1 0.0003 Vitamin B2 0.0003 Vitamin B6 0.00046 Vitamin B12 0.00000113 Vitamin c 0.0534 Vitamin D3 0.000275 Vitamin E 0.003 Vitamin K 0.00035 Calcium Pantothenate 0.000875 Niacin 0.00263 Folic acid 0.0000325 Biotin 0.000002 Choline chloride 0.00035

3) Powder feed for landscape feeding

Soybean Caine or Soy Protein Isolate or Soy Protein Isolate Soy Protein 70:30 18.44g, Dextrin 64.25g, Frutan Dietary Fiber 6.45g, Oxygen Oil 10.6g, MCT Oil 2.7g, Lecithin 0.3g, Bio-M 0.133 After dissolving g in purified water, sterilized, homogenized, concentrated and spray-dried by adding vitamins and minerals as shown in Table 3 to prepare a powder enteral nutritional product for tube feeding.

The ratio of vitamins and minerals in landscape feeding products Name Usage% of Example 4 Usage% of Example 5 Potassium citrate 0.52 0.13 Sodium citrate 1.25 0.313 Magnesium chloride 0.8 0.2 Potassium chloride 0.45 0.113 Dicalcium Phosphate 1.10 0.275 Zinc sulfate 0.023 0.006 Copper sulfate 0.00175 0.00044 Ferrous sulfate 0.022 0.0055 Dibasic Potassium Phosphate 0.11 0.0275 Manganese sulfate 0.0031 0.00078 Potassium Iodine 0.000065 0.0000163 Vitamin A palmitate 0.004 0.001 Vitamin B1 0.0012 0.0003 Vitamin B2 0.0012 0.0003 Vitamin B6 0.00183 0.00046 Vitamin B12 0.0000045 0.00000135 Vitamin c 0.2135 0.0534 Vitamin D3 0.0011 0.000275 Vitamin E 0.048 0.012 Vitamin K 0.0014 0.00035 Calcium Pantothenate 0.0035 0.00088 Niacin 0.0105 0.00263 Folic acid 0.00013 0.0000325 Biotin 0.00008 0.000022 Choline chloride 0.0014 0.00035

4) Liquid entertaining food for landscape feeding

Soy Casein Soy Protein, Soy Protein Isolate or Soy Protein Isolate Soy Protein 70:30 4.61%, Dextrin 16.06%, Dietary Fiber 1.61%, Oxygen Oil 2.65%, MCT Oil 0.68%, Lecithin 0.1%, Fractan Dietary Fiber 1.61% , Dissolve 0.04% of Bio-M in purified water, add vitamins and minerals as shown in Table 3, adjust the total volume to 100ml, and homogenize, package, retort sterilize or sterilize the liquid enteral culture for tube feeding. Manufacture the product.

5) Powder enteral diet for patients with renal failure

Milk protein (Kysine or Casein Sodium and Kesin Hydrolysate), vegetable protein (Isolated Soy Protein or Soy Protein Isolate) can be a single protein source or 9.48g of milk protein and vegetable protein 70:30 mixture, 60.4g dextrin, 10.64g canola oil , 15.95 g of jade oil, 0.35 g of lecithin, 6.45 g of fructan dietary fiber, and 0.133 g of Bio-M were dissolved in purified water and added with vitamins and minerals as shown in Table 4 to disinfect, homogenize, concentrate, and spray dry them to avoid hemodialysis. Prepare a powder enteral nutrition product for patients with renal failure.

6) Liquid enteral culture for patients with renal failure without hemodialysis

Milk protein (casein or casein and casein hydrolysates) and vegetable protein (separated soy protein or soy protein isolate) can be derived from a single protein source or a mixture of milk protein and vegetable protein 70:30 2.35%, dextrin 15.1%, canola oil 2.66% , Jade oil 3.99%, lecithin 0.1%, fructan dietary fiber 1.61%, Bio-M 0.04% dissolved in purified water and added to vitamins and minerals as shown in Table 4 to adjust the total volume to 100ml homogeneous, packaging, retort A liquid enteral culture is prepared for patients with renal failure who do not undergo dialysis by sterilization or sterilization.

7) Powder enteral form for patients with renal failure with hemodialysis

Milk protein mixture (hydrolysed whey protein and sodium kesin 50:50) 22.81 g, dextrin 46.72 g, canola oil 10.82 g, jade oil 16.24 g, lecithin 0.35 g, fructan dietary fiber 6.45 g, Bio-M 0.133 g dissolved in purified water Dissolve well, and then add vitamins and minerals as shown in Table 4 to prepare a powder enteral diet for renal failure patients who are undergoing hemodialysis by sterilization, homogenization, concentration, and spray drying.

Alternatively, 22.81 g of a mixture of sodium and lysine 50:50, 46.72 g of dextrin, 10.82 g of canola oil, 16.24 g of jade oil, 0.35 g of lecithin, 6.45 g of fructan dietary fiber, and 0.133 g of Bio-M were dissolved in purified water. As shown in Table 4, sterilized, homogenized, concentrated and spray-dried by adding vitamins and minerals to prepare a powder enteral diet for renal failure patients undergoing hemodialysis.

8) Powder Enteral Diet for Hemodialysis Kidney Disease Patients

Sodium kesin and hydrolyzed soy protein 50:50 22.81 g, dextrin 46.72 g, canola oil 10.82 g, jade oil 16.24 g, lecithin 0.35 g, fructan dietary fiber 6.45 g, Bio-M 0.133 g, dissolved in purified water and stirred Here, as shown in Table 4, sterilized by adding vitamins and minerals, and then concentrated and spray-dried to prepare a powder enteral diet for hemodialysis kidney disease patients.

In addition, 22.81 g of the soy protein and whey protein hydrolysate 50:50 mixture, dextrin 46.72 g, canola oil 10.82 g, jade oil 16.24 g, lecithin 0.35 g, fructan dietary fiber 6.45 g, and Bio-M 0.133 g were dissolved in purified water. After stirring and sterilizing by adding vitamins and minerals as shown in Table 4, concentrated and spray-dried to prepare a powder enteral diet for hemodialysis kidney disease patients.

As another example, the purified soy protein and soy protein hydrolysate 50:50 mixture 22.81 g, dextrin 46.72 g, canola oil 10.82 g, jade oil 16.24 g, lecithin 0.35 g, fructan dietary fiber 6.45 g, Bio-M 0.133 g purified water Dissolve in and stir, add vitamins and minerals as shown in Table 4, sterilize, concentrate and spray dry to prepare a powder enteral diet for hemodialysis kidney disease patients.

40% of the main raw materials, including the protein source used in the diet for kidney failure and kidney disease, are dissolved in purified water, and the vitamins and minerals as shown in Table 4 are added, and then the total volume is adjusted to 100 ml, homogeneous, packaged, and retort. Sterilized or sterilized to prepare a liquid enteral culture for hemodialysis renal failure patients.

Percentage of Vitamins and Minerals in Enteral Nutritional Products for Kidney Disease Patients Name Non-dialysis patient formula Dialysis patient formula Powder product Liquid product Powder product Liquid product Potassium citrate 0.586 0.15 0.5 0.2 Sodium citrate 0.143 0.036 - - Magnesium chloride 0.476 0.119 0.475 0.19 Potassium chloride 0.083 0.021 0.15 0.06 Tricalcium Phosphate - 0.34 0.136 Calcium carbonate - 0.59 0.236 Zinc sulfate 0.027 0.0068 0.027 0.011 Copper sulfate 0.00219 0.00055 0.0022 0.00088 Ferrous sulfate 0.025 0.0063 0.025 0.01 Dibasic Potassium Phosphate 0.0595 0.015 0.024 0.0096 Manganese sulfate 0.004 0.001 0.004 0.0016 Potassium Iodine 0.000062 0.0000155 0.00006 0.000024 Vitamin A Palmitate 0.000326 0.0000815 0.00033 0.000132 Vitamin B1 0.0011 0.00028 0.0012 0.00048 Vitamin B2 0.00107 0.00027 0.00107 0.000428 Vitamin B6 0.0037 0.00093 0.0037 0.00148 Vitamin B12 0.0000041 0.000001025 0.0000042 0.00000168 Vitamin c 0.0476 0.0119 0.0476 0.019 Vitamin D3 0.00026 0.000065 0.00026 0.001 Vitamin E 0.0152 0.0038 0.0152 0.0061 Vitamin K 0.00055 0.00014 0.00055 0.00022 Calcium Pantothenate 0.00476 0.00119 0.00476 0.0019 Niacin 0.0083 0.0021 0.0083 0.00332 Folic acid 0.00031 0.000078 0.00035 0.00014 Biotin 0.00013 0.000033 0.00014 0.000056 Choline chloride 0.214 0.054 0.214 0.086

8) Powder Enteral Diet for Chronic Liver Disease Patients

Whey Protein Hydrolyzate 9.72g, Sodium Kaycin 6.75g, L-Leucine 1.18g, L-Isoleucine 1.83%, L-Valine 2.03g, Dextrin 40g, Sugar 25g, Soybean Oil 7.35g, MCT Oil 3.15g, Lecithin 0.35g 6.45g of fructan dietary fiber and 0.133g of Bio-M are dissolved in purified water, and vitamins and minerals are added as shown in Table 5, followed by sterilization, homogenization, concentration, and spray drying to prepare a powder enteric diet for chronic liver disease patients.

9) Liquid enteral culture for chronic liver disease patients

Whey Protein Hydrolyzate 2.43%, Caine Sodium 1.69%, L-Leucine 0.3%, L-Isoleucine 0.46%, L-Valine 0.51%, Dextrin 10%, Sugar 6.25%, Soybean Oil 1.84%, MCT Oil 0.79%, Lecithin 0.1%, fructan dietary fiber 2.53%, Bio-M 0.04% is dissolved in purified water, vitamins and minerals are mixed as shown in Table 5 and then homogeneous, retort sterilization or sterilization to prepare a liquid enteral diet for chronic liver disease patients.

Vitamin and Mineral Ratio of Enteral Nutritional Products for Chronic Liver Disease Patients (%) Name Powder Enteral Nutritional Use (%) Liquid Enteral Nutritional Use (%) Potassium citrate 0.4 0.16 Magnesium chloride 1.5 0.6 Potassium chloride 0.3 0.12 Tricalcium Phosphate 1.4 0.56 Zinc sulfate 0.029 0.0012 Copper sulfate 0.0038 0.00152 Ferrous sulfate 0.043 0.0172 Dibasic Potassium Phosphate 0.6 0.24 Manganese sulfate 0.005 0.002 Potassium Iodine 0.0001 0.00004 Vitamin A palmitate 0.00831 0.003324 Vitamin B1 0.00115 0.00046 Vitamin B2 0.001 0.0004 Vitamin B6 0.0015 0.0006 Vitamin B12 0.000004 0.0000016 Vitamin c 0.2 0.08 Vitamin D3 0.0022 0.00088 Vitamin E 0.034 0.0136 Vitamin K 0.0014 0.00056 Calcium Pantothenate 0.005 0.002 Niacin 0.0085 0.0034 Folic acid 0.00025 0.0001 Biotin 0.00015 0.00006 Choline chloride 0.24 0.096 L-carnitine 0.055 0.022

10) Powder Enteral Nutrition for Diabetics

Sodium lysine or lysine protein: 29.63 g mixture of soy protein 70:30, 26.72 g dextrin, 10.13 g fructan dietary fiber, 25 g canola oil, 0.35 g lecithin, and 0.133 g Bio-M in purified water And minerals are mixed and then sterilized, homogenized, concentrated and spray-dried to prepare a powdered diet for diabetic patients.

11) Liquid enteral culture for diabetics

Sodium lysine or lysine and soy protein 70:30 mixture 7.41%, dextrin 6.68%, fructan dietary fiber 2.53%, canola oil 6.25%, lecithin 0.1%, Bio-M 0.04% in purified water and then as shown in Table 6 Mixing vitamins and minerals uniformly to adjust the total volume to 100ml to homogeneous, retort sterilization or sterilization to prepare a liquid entertaining diet for diabetic patients.

Vitamin and mineral compounding ratio of enteral culture for diabetic patients (%) Name Usage of Powdered Nutrition (%) % Of liquid nutrition Potassium citrate 2.5 0.625 Magnesium chloride 1.063 0.266 Potassium chloride 0.563 0.141 Tricalcium Phosphate 1.375 0.344 Zinc sulfate 0.059 0.0148 Copper sulfate 0.005 0.00125 Ferrous sulfate 0.05 0.0125 Dibasic Potassium Phosphate 0.025 0.00625 Manganese sulfate 0.00675 0.00169 Potassium Iodine 0.000137 0.00003425 Vitamin A palmitate 0.0025 0.000625 Vitamin B1 0.002 0.0005 Vitamin B2 0.002 0.0005 Vitamin B6 0.00263 0.000658 Vitamin B12 0.000007 0.00000175 Vitamin c 0.4 0.1 Vitamin D3 0.00288 0.00072 Vitamin E 0.0775 0.0194 Vitamin K (5%) 0.001188 0.000297 Calcium Pantothenate 0.00875 0.00219 Niacin 0.015 0.00375 Folic acid 0.000375 0.0000938 Biotin 0.00025 0.0000625 Choline chloride 0.4375 0.1094 L-carnitine 0.0625 0.0156

12) Enteral culture for patients with digestive diseases

13.2 g of succinic acid-modified maize starch was dissolved in purified water, dispersed, and then slowly warmed up to 80 ° C., followed by 35.6 g of dextrin, 4.34 g of canola oil, 1.86 g of MCT oil, 1.08 g of L-arginine, and 4.21 g of fructan dietary fiber. Dissolve and mix 0.133 g of M, then mix the vitamins and minerals in Table 7 to homogenize, sterilize, concentrate, and spray dry. In addition, spray-dried powder, a mixture of 35% casein hydrolyzate and 65% wheat protein hydrolyzate, is mixed with 20% or more of sugar and 20% or more of carbohydrates.

13) Deodorizing Products

It is a tablet or powder product containing 40% of pine mushroom extract (Bio-M), 40% dextrin and 20% sugar.This product is used for intestinal digestion in patients with abnormal fecal excretion, such as colon cancer. It is a deodorizing product designed to minimize the occurrence of odor from feces.

Vitamin and mineral compounding ratio of enteral culture for patients with digestive diseases (%) Name usage(%) Potassium citrate 0.04 Sodium citrate 0.48 Magnesium chloride 1.44 Potassium chloride 0.2 Tricalcium Phosphate 0.92 Zinc sulfate 0.0396 Copper sulfate 0.00246 Ferrous sulfate 0.0336 Dibasic Potassium Phosphate 0.4 Manganese sulfate 0.0042 Potassium Iodine 0.000064 Vitamin A Palmitate 0.00208 Vitamin B1 0.00144 Vitamin B2 0.00124 Vitamin B6 0.003 Vitamin B12 0.0000052 Vitamin c 0.28 Vitamin D3 0.0014 Vitamin E 0.016 Vitamin K 0.001 Calcium Pantothenate 0.0068 Niacin 0.0112 Folic acid 0.000252 Biotin 0.000168 Choline chloride 0.22 Taurine 0.084 L-carnitine 0.044

As described above, the present invention provides specific nutrition of patients who have caloric ratios of protein, fat, and carbohydrates as food substitutes and nutritional snacks for general patients, patients with renal failure, patients with chronic liver disease, patients with diabetes, and digestive diseases. Formulated to provide nutrients according to the requirements, and the combination of matsutake extract and fructan dietary fiber to selectively promote the growth of Bifidobacteria in the intestinal flora of the patient, facilitating defecation and digestion of food including feces It is the development of enteral culture that can minimize the occurrence of the resulting odor. And the product contained in the present invention as a deodorant product is not a nutritionally complete product is a product designed to suppress the occurrence of odor only by ingestion only 3-4 times a day.

The present invention provides an enteral diet comprising a hydrophilic solvent extract of Agaricus bisporus flesh and fructan fiber, particularly for kidney failure patients, kidney disease patients, chronic liver disease patients, diabetic patients or digestive disease patients. By providing a special nutritional supplement or health supplement for patients, such as nutrition, there is an advantage of preventing or minimizing the occurrence of feces and diarrhea when ingested enteric nutrition.

Claims (5)

Enteral culture, characterized in that it comprises a hydrophilic solvent extract of the mushroom (Agaricus bisporus) flesh and fructan fiber (fructan fiber). The enteral diet of claim 1, wherein the nutritional formula is in powder form or liquid form. The method of claim 2, wherein in the case of powdered enteric culture, the hydrophilic solvent extract of the pine mushroom flesh contains 0.1 to 0.4 g per 100 g and the fructan dietary fiber contains 2.5 g to 8 g per 100 g. According to claim 2, wherein the hydrophilic solvent extract (Bio-M) of the pine mushroom flesh containing 0.6g to 2g per 100ml and liquid fructose diet containing 0.04g to 0.016g per 100ml Characteristic entertaining. The enteral diet according to any one of claims 1 to 4, wherein the enteral diet is a general diet, a dietary supplement, a kidney failure patient, a chronic liver disease patient, a diabetic patient or a special diet for digestive diseases.