KR20020011718A - Cosmetic composition for dry skin of atopic dermatitis - Google Patents

Abstract

PURPOSE: A composition comprising N-stearoyl-phytosphingosine as a main component is provided, which has a synergistic effect on improving dermatoxerasia of atopic dermatitis and restoring force of damaged skin. CONSTITUTION: This skin-care composition comprises lotus root powder, buckwheat powder, onion powder and N-stearoyl-phytosphingosine in a ratio of 2:2:2:4. The cosmetic containing the composition has an excellent moisturizing effect and dry preventing effect and may be provided in the form of skin lotion, lotion, massage cream, nourishing cream, pack or gel.

Description

Composition for improving dry skin recovery of atopic dermatitis and cosmetics comprising the same {Cosmetic composition for dry skin of atopic dermatitis}

The present invention relates to a composition and a cosmetic comprising the same to improve the moisturizing function of the skin and to restore the barrier function by regulating the formation of the stratum corneum to improve the skin dryness of atopic dermatitis and damaged skin barrier. More specifically, lotus root powder, buckwheat powder, onion powder and N-stearoyl-phytosphingosine of the following structural formula (I) in parts by weight 2: 2: 2: 4, itching of atopic dermatitis The present invention relates to a composition for improving skin moisturizing effect and anti-drying effect and recovery of damaged skin barrier, which is excellent for improvement and dry skin.

(1) With atopic dermatitis.

The term atopy (atopy) has the meaning of "weird" or "inappropriate", and the cause of atopic dermatitis is not yet clearly identified, so the symptoms are also expressed in various ways, such as dry skin, eczema. Atopic dermatitis, also known as fever, is accompanied by chronic diseases of the skin, as well as allergic diseases such as hay fever. This disease is called allergic eczema, pediatric eczema, ectopic eczema, pancreatic neurodermatitis, etc. and is a clinical category of clinical and histological processes that show progression from infant eczema to typical thyroid dermatitis in boys, puberty, and adults. .

Atopic dermatitis is a chronic relapsing eczema disease, the cause and pathogenesis of which are not clear. It is now understood that atopic dermatitis is mainly caused by a unique genetic predisposition, but its cause is not simple and is caused by a multi-factorial. Several external environmental factors that are involved in exacerbation of atopic dermatitis are well known, and the genetic predispositions present in patients with atopic dermatitis and their families, as well as their clinical and immunological forms, are currently weak. Immunological abnormalities due to genetic predisposition have been understood as the main etiology, and evidences suggest immunological abnormalities such as increased Ig E in blood, increased IL-4 and IL-5, and decreased INF-γ. However, the most clinically characteristic findings of dry skin and eczema are not explained as immunological abnormalities, and it is not clear whether they are genetic or secondary to atopic dermatitis.

(2) Abnormal findings of skin observed in atopic dermatitis.

-The size of the stratum corneum cells is abnormally reduced.

The thickness of the epidermal cell layer is increased.

-The moisture content in the stratum corneum is reduced.

-Water content in epidermis is low.

-The natural moisturizing factor is reduced.

-Transepidermal water loss is increased.

The amount of lipids in the stratum corneum is reduced. Especially ceramide

Synthetic disorders result in a reduced amount of ceramide.

-Abnormalities in lipid metabolism in the epidermis.

-Lamellar bodies are increased but secretory function is impaired

have.

(3) why dry skin is a problem in atopic dermatitis

Since atopic dermatitis is chronically dry, eczema is easily induced by various stimuli, severe pruritus, and recurring recurrence. These pruritus and eczema are repeatedly exacerbated by dry skin and, if not properly managed, eventually progress to subacute and chronic lesions such as thyroiditis, pigment change, and erythematosis. Superficial folliculitis, phytillofoscle folliculitis, epidemics, superficial dermatitis, warts, and recurrent herpes simplex are common with immunological abnormalities. Bacterial infections are usually caused by coagulase-positive Staphylococcus aureus, and appear mainly as folliculitis lesions with superficial pruritus on the arms and legs, and are not accompanied by deep tissue abscesses and cellulitis, but are accompanied by severe recurrent annular eczema lesions. The case may cause recurrent cellulitis with systemic symptoms. Therefore, the use of a moisturizer to improve the skin dryness of atopic dermatitis and the increase of resilience of skin barrier function occupy an important position in the treatment of atopic dermatitis.

(4) Why physiological lipid combinations are important for dry skin of atopic dermatitis

As described above, the amount of lipids in the stratum corneum is reduced with abnormalities of lipid metabolism in the epidermis. In particular, ceramide-containing disorders are reduced in the amount of ceramide. Non-physiological lipids, such as waselin and mineral oil, remain in the stratum corneum primarily after skin barrier injuries to act as skin barriers, whereas physiological lipids, such as ceramide, penetrate into the epidermis and enter the keratinocytes through intracellular incorporation. It is known to help the recovery. Therefore, rather than physiological lipid mixtures such as sphingolipids (ceramides) contained in the formulation, rather than non-physiological lipids such as waselin and mineral oil and commercially used simple moisturizing ingredients, dry skin due to increased moisturizing ability in atopic dermatitis As well as improvement, it plays an important role in the recovery of skin barrier function in skin barrier damage diseases.

Until now, alban moisturizers have been used to alleviate dry skin observed in atopic dermatitis, but the effect was temporary due to increased moisture by the applied moisturizing ingredients, and it was not effective in improving the resilience of skin barrier function. .

The present invention provides the supply and loss of skin moisture by the conventional skin moisturizing agent technology under the concept of excellent moisturizing effect, anti-drying effect and bactericidal effect to reduce itching and skin barrier recovery from atopic dermatitis. It is an object of the present invention to provide a mixture of active ingredients which is effective in further enhancing the prevention effect and in promoting bactericidal effect for improving skin barrier resilience and relieving itching. To achieve this purpose, buckwheat powder with excellent skin moisturizing ability, lotus root powder, onion powder with excellent bactericidal action against itching, and skin with atopic dermatitis are reduced in skin and physiological lipids of skin have excellent ability to prevent water loss. When the stearoyl-phytosphingosine mixture is used in combination, the present invention has been found to improve the moisturizing effect, the bactericidal effect and the prevention of drying as well as the recovery of the skin barrier.

Accordingly, an object of the present invention is to provide a composition having a bactericidal effect and an effect of improving the resilience of damaged skin barriers and cosmetics comprising the same for moisturizing ability, anti-drying effect and reduction of itching for skin dryness in atopic dermatitis.

In order to achieve the above object, the composition for improving the itching and skin dryness of atopic dermatitis according to the present invention and the recovery of damaged skin barriers and the cosmetics comprising the same include lotus root powder, buckwheat powder and onion powder and N of the following structural formula -Stearoyl-phytosphingosine (N-stearoyl-phytosphingosine) is characterized by containing a weight part 2: 2: 2: 4.

Hereinafter, the present invention will be described in more detail.

The composition of the present invention contains onion powder, lotus root powder, buckwheat powder.

Onion powder is prepared by the following method. 1) Remove the outer skin of onion, wash it with clean water to remove water and dry it in the shade for 48 hours. 2) After placing it in the water bath, add 10 times the amount of water and steam it at 90C for 1 hour while the cooling capacitor is attached to prevent the active ingredient from evaporating. 3) After cooling down completely, remove and dry for 24 hours in a well-ventilated shade. 4) Repeat the process of 2) and 3) eight more times. 5) Using a jet mill, finely grind to a size of 5-10 micrometers. 5) Refrigerate at 4C.

Lotus root powder is prepared by the following method. 1) After washing the lotus root, cut it into 5cm size and dry it for 48 hours in the shade. 2) Put in a bath and steam for 2 hours in the same way as above. 3) The rest of the process is the same as the onion powder manufacturing process.

Buckwheat powder is prepared by the following method. 1) Wash buckwheat thoroughly and dry for 48 hours in the shade. 2) Put it in a bath and steam for 4 hours as described above. 3) The rest of the process is the same as the onion powder manufacturing process.

The composition of the present invention contains N-stearoyl-phytosphingosine. Molecular weight is 584.0 and N-octadecanoyl-phytosphingosine (N-Octa

decanoyl-phytospingosine), N-stearoyl-4D-hydroxyspinganine (N-Stearoyl-4D-

hydroxysphinganine) or (2S, 3S, 4R) -2-stearoylamido-1,3,4-octadecanetriol ((2S, 3S, 4R) -2-Stearoylamido-1,3,4-octadecanetriol) Also called.

The composition for improving the skin barrier recovery in atopic dermatitis of the present invention to improve the itching and dry skin and skin barrier damage diseases such as atopic dermatitis, irritant dermatitis or allergic dermatitis, younger, psoriasis is not particularly limited in the formulation . For example, it may be a cosmetic composition having a flexible cosmetic water, nourishing cosmetics, massage cream, nourishing cream, pack, gel or adhesive type formulation. In addition, 0.01 to 10.00% by weight of the above-mentioned lotus root powder, 0.01 to 10.00% by weight of buckwheat powder, 0.01 to 10.00% by weight of onion powder and / or N-stearoyl-phytosphingosine (N) Ingredients other than -stearoyl-p hytosphingosine) can be appropriately selected and blended by the inventor without difficulty according to the formulation or purpose of use of other cosmetic compositions.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to the following Examples.

<Comparative Examples 1 to 4 and Examples 1 to 4>

The components 19, 12, 13, and 14 were mixed and the temperature was adjusted to 70 degreeC (sample 1). The components 1,2,3,4,5,6,7,8,9,10 were mixed and the components 11 were mixed in Comparative Example 5 and Example of Table 1 to adjust the temperature to 70 ° C. (Sample 2). Sample 2 was added to Sample 1, emulsified at 3600 rpm / 3 minutes, and then cooled to 50 ° C. with cooling water, followed by component 16 for Comparative Example 2 and Example, and component 17 for Comparative Example 3 and Example. In the case of Comparative Example 4 and Example, Component 18 was included, except that, only Component 15 was added and stirred well, followed by cooling to 30 ° C. The component ratios of Comparative Examples 1 to 5 and Examples 1 to 4 are summarized in Table 1.

ingredient Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Example 1 Example 2 Example 3 Example 4 1. Vegetable Cured Oil 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 2. Stearic acid 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 3. Cetostearyl Alcohol 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 4. Monostearic acid polyoxyethylene sorbitan (20EO) 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 5. Capryl / Capric Triglyceride 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 6. Cetyl Octanoate 4.00 4.00 4.00 4.00 4.00 4.00 4.00 4.00 4.00 7. Cyclomethicone 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 8. Methylparaben 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 9. Propylparaben 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 10. Squalane 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 11.N-Stearoyl-Phytosphingosine - - - - 0.50 0.10 0.10 0.30 0.50 12. Glycerin 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 13. Disodium EDTA 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 14. Triethanolamine 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 15. Carboxyvinyl Polymer 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 16. Lotus root powder - 1.00 - - - 0.50 1.00 1.00 1.00 17. Buckwheat Powder - - 1.00 - - 0.50 1.00 1.00 1.00 18. Onion Powder - - - 1.00 - 0.50 1.00 1.00 1.00 19. Purified water to100 to100 to100 to100 to100 to100 to100 to100 to100

<Test Example 1> Recovery test effect after skin barrier damage in hairless mice

Acetone was applied as a method of skin barrier damage. Acetone was added to the embryos of 8-12 week old hairless mice, and when the transepidermal water loss (TEWL) reached 4.0 g / m 2 / h, the sample containing the composition of Table 1 was applied to an area of 5 cm 2. TEWL was measured with Tewameter 210, an evaporimeter of C-K (Courage + Khazaka, Cologne, Germany). After 6 hours of application, TEWL was measured to evaluate the extent to which TEWL was reduced to evaluate the extent to which skin barrier function was restored. Calculation of the recovery rate used for the efficacy evaluation was calculated as in the following equation 1 and the results are shown in Table 2.

(Equation 1)

Br (Barrier Recovery) = (1-(B _{t = 6} -B _{t = 0} ) / (B _{t = d} -B _{t = 0} )) * 100

B _{t = 6} : TEWL measured 6 hours after skin barrier injury

B _{t = 0} : TEWL measurement before skin barrier injury

B _{t = d} : TEWL measured immediately after skin barrier injury

Recovery rate (%) 6 hours elapsed (based on initial TEWL) Comparative Example 1 17.2 Comparative Example 2 39.5 Comparative Example 3 37.69 Comparative Example 4 24.5 Comparative Example 5 52.1 Example 1 53.3 Example 2 58.5 Example 3 68.4 Example 4 78.0

<Experiment Result>

Looking at the results of Table 2, the damage to the skin barrier in the case of mixing these components (Examples 1, 2, 3, 4) rather than each of the components as an active ingredient (Comparative Examples 2, 3, 4, 5) The recovery effect was later increased.

Experimental Example 2 Inhibitory Effect of Hyperkeratosis in Hairless Mice

100 μl of oleic acid was applied once a day to induce skin irritation and hyperkeratosis in 8-12 week old hairless mice. The control group was applied only oleic acid for 7 days. After applying the oleic acid for 7 days, the test group was applied to Comparative Examples 1 to 4 and Examples 1 to 4 in 100 μl each for 7 days. After 7 days from the start of the test, the outermost stratum corneum was separated by D-squame tape from the embryos of hairless mice. The amount of keratin was quantified to assess the degree of hyperkeratosis. The hyperkeratosis inhibition rate used in the efficacy evaluation was calculated as shown in Equation 2 as a relative amount with the amount of keratin produced by oleic acid as 100 after calculating each keratin amount and the results are shown in FIGS. 1 and 3.

(Equation 2)

Stratum Corneum = Sn * Sa

Sn: number of keratin per unit area

Sa: average area of individual keratin

Hyperkeratosis inhibition rate = (1-(Si / So)) * 100

Si: keratin amount of each test group

So: keratin amount by applying oleic acid

Applicator Hyperkeratosis inhibition rate (%) Comparative Example 1 32.5 Comparative Example 2 44.2 Comparative Example 3 42.3 Comparative Example 4 37.6 Comparative Example 5 48.7 Example 1 50.8 Example 2 57.5 Example 3 65.9 Example 4 83.1

<Experiment Result>

Looking at the results of Table 3, the effect of inhibiting hyper-cornering when these components were mixed (Examples 1, 2, 3, 4) than when each component was used as an active ingredient (Comparative Examples 2, 3, 4, 5). Appeared to rise.

Test Example 3 Measurement of Skin Moisturizing Power by Human Experiment

The skin moisturizing power was compared with respect to the cosmetic prepared by Table 1 above. Skin moisturizing ability was measured in 10 normal 20 to 30 adults. The test method is as follows. The skin conductivity was measured by using a corneometer (CM820 Courage + Khazaka, Cologne, Germany) under constant temperature and humidity conditions (24 ℃, 40% humidity) before starting the application using the forearm part of the subject as the test site. 9 sites were randomly selected, and after application of uncoated sites, Comparative Examples 1 to 4, and Examples 1 to 4, the change in skin conductivity after 2, 4, and 8 hours was measured to determine the skin moisturizing effect. The moisture content changed from the initial value was calculated as shown in Equation 3, and the results are shown in Table 4.

(Equation 3)

Moisture growth rate M (Moisturization) = ((M _{t = i} -M _{t = 0} ) / M _{t = 0} ) * 100

M _{t = i} : Moisture content measured at t = i hours

M _{t = 0} : Moisture measured immediately before the start of the test at the unapplied area (t = 0)

Skin moisture growth rate (corneometer) Skin moisture growth rate (%) After 2 hours After 4 hours After 8 hours Comparative Example 1 40 24 16 Comparative Example 2 59 31 23 Comparative Example 3 54 39 22 Comparative Example 4 45 37 17 Comparative Example 5 68 35 25 Example 1 68 40 31 Example 2 77 54 40 Example 3 85 61 42 Example 4 102 92 76

<Experiment Result>

As shown in Table 4, in the case of the mixed composition of Example 4 in increasing skin moisture, the effect was found to increase most.

Experimental Example 4 Determination of Arid Dermatitis Improvement of Skin Dryness and Damage to Damaged Skin Barrier

For the cosmetics prepared in Example 4 and Comparative Example 1 of Table 1, 20 test subjects with atopic dermatitis were measured to improve skin dryness and recovery of damaged skin barrier. The test method is as follows.

Subjects were randomly divided into two sets, each of which was given Example 4 and Comparative Example 5, and applied to dry areas (limbs or face) twice a day for one month. The skin conductivity was measured at the test site before and after 4 weeks of application, and 5 sites were selected before and after application to measure the change in skin conductivity, and the effect of improving the dry skin of the sample was evaluated and the results are shown in Table 5. The effect of improving skin dryness was calculated using the moisture content change of Equation 4. In addition, the biopsy was performed before the start of the test and 4 weeks after application, and the change in the distribution of calcium ions was observed by electron microscopy. In addition, the outermost stratum corneum was separated by D-squame tape from the dry area before and after the test start, and the D-squame was saved with a CCD camera, and the amount of keratin on the tape was quantified by BMI's Image analyzer program BMI. The efficacy was evaluated by comparing the amount of keratin before and after use. The hyperkeratosis inhibition rate used for the evaluation is shown in Equation 5 and Table 6.

(Equation 4)

Skin dryness improvement effect = ((M _a -M _n ) / M _n ) * 100

M _a : Moisture content measured at the application site after 4 weeks of material application

M _n : Moisture content measured at the uncoated area after 4 weeks of material application

Applicator Skin dryness improvement effect (%) Comparative Example 1 20.5 Example 4 66.9

(Eq. 5)

Stratum Corneum = Sn * Sa

Sn: number of keratin per unit area

Sa: average area of individual keratin

Hyperkeratosis Inhibition Rate = (1-(Ai / Ao)) * 100

Ai: keratin quantity of each test group

Ao: Initial keratin volume when no material is applied

Applicator Hyperkeratosis inhibition rate (%) Comparative Example 1 13.7 Example 4 42.3

<Experiment Result>

In Table 5, it can be seen that the application of the mixed composition of Example 4 is excellent in the effect of improving dry skin in dry skin of atopic dermatitis. In FIG. 2, abnormalities can be observed in the distribution of calcium ions in the dry skin of atopic dermatitis, and the distribution of calcium ions is restored to the normal calcium gradient by the application of the mixed composition of Example 4. It can be seen that the mixed composition is excellent in improving skin barrier recovery ability. In addition, in Table 6, the mixed composition of Example 4 was found to have an excellent inhibitory effect on the hyperkeratosis in skin dryness.

As described above, the cosmetic composition provided by the present invention is used by mixing lotus root powder, buckwheat powder, onion powder and N-stearoyl-phytosphingosine (structure II) in a weight part 2: 2: 2: 4 It can be seen that the synergistic effect in the improvement of the dry skin of atopic dermatitis and the recovery of damaged skin barrier than using a single or two other compounds.

Claims (1)

Contains lotus root powder, buckwheat powder, onion powder, and N-stearoyl-phytosphingosine in parts by weight 2: 2: 2: 4 to improve the dryness of atopic dermatitis and the recovery of damaged skin barrier Composition exhibiting synergistic effect.