KR20010097012A - The Cosmetic Compositions for Controlling Sebum and Anti-Acne - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising acinidyl, which is a mixture of amino acids, sulfopeptides, vitamin B, xanthine, zinc salt, etc. having a function of sebum control, and the cosmetic composition of the present invention is applied to the skin. When it is done, it has an excellent effect on preventing and alleviating acne by improving the skin prone to acne due to excessive secretion of sebum due to hormone imbalance.

Description

The Cosmetic Compositions for Controlling Sebum and Anti-Acne}

The present invention relates to sebum control and anti acne cosmetic composition. More specifically, the present invention relates to a cosmetic composition comprising acinidyl, which is a mixture of amino acid, sulfopeptide, vitamin B, xanthine, zinc salt and the like with sebum control function.

Acne is known to be caused by a combination of three factors: sebum oversecretion due to the action of hormones, keratinocyte hyperkeratosis of sebaceous glands and involvement of acne bacteria in propion bacteria. Abnormal hyperkeratosis of the sebaceous gland in the sebaceous glands causes thickening of the inner wall of the sebaceous gland, causing the sebaceous glands to be blocked, and as the secretion of sebum increases, the sebum produced continues to accumulate in the sebaceous gland, thereby promoting acne. do. When you squeeze it out, something like sebum or sebum is pushed out. These rashes are called cotton cloth.

Acne often occurs in teenagers who are in puberty because they are mostly neutral or oily. Acne is a lot of oily skin, because if the secretion of oil, sebum secreted by sebaceous glands, oil in the cells of the stratum corneum increases, so bacteria are more likely to grow, and sebum secretion does not decrease even when the pores are clogged. As the bacteria get tangled up, acne is produced and male hormone production is vigorous, the sebaceous glands are stimulated, and the secretion of sebum becomes more active, which leads to the clogging of pores.

Acne occurs mainly in areas where there are more than 3 million sebaceous glands, such as the face, neck, back, and chest.In the form of acne, the acne is divided into a white cloth, a closed cloth, a black cloth, a red acne, and purulent acne. Cotton cloth is characterized by protruding skin of Otoldol like millet, with sebum that is not secreted sebum 1 ~ 2 mm below the surface of the skin. Second, black cloth, which is an open cotton cloth, ends when the sebaceous mass of the white cloth blocks the pores. This black color is often caused by black spots that look like black spots, and red acne is a stage in which red acne is swollen and painful with acne-infected acne. Lastly, purulent acne is aggravating acne and leaving a yellowish scar.

For the technicians involved in this technology, a comprehensive analysis of the causes of acne, a common known fact, shows that the secretion of sebaceous glands is increased by androgen, a male hormone. The walls of the pores and sebaceous glands become thicker, leading to sebaceous glands and inflammation, leading to acne.

Typically, this hormone is produced by the testicles in men and in the ovaries and adrenal glands. In contrast, estrogen acts to inhibit sebaceous glands, but not directly. The composition of the sebaceous glands secretion is squalene (10), triglyceride (10), fatty acid (60), wax (wax) 20. Therefore, when choosing cosmetics, it is very important to use cosmetics that have a lot of fatty acids or waxes and good cosmetics. There are usually local and systemic treatments for acne. Topical therapy is a method of cleansing the skin and exfoliating hair follicles by removing the stratum corneum so as to facilitate sebum secretion. It is a method of sterilizing acne bacteria using triclosan or hexaclorophen. However, care should be taken that it can cause contact dermatitis. In addition, retinoic acid is a vitamin derivative that inhibits the formation of microsurface vesicles and is an agent that acts to reduce the number of vesicles formed. This is important for reducing the adhesion of keratinocytes in the hair follicles, so it is effective in treating acne with the addition of scleral disease. High concentrations cause irritation such as erythema and sulphate, so use a cream or gel form of 0.01 to 0.05.

Benzol peroxide (Phenyl peroxide) reduces P. acne (propion bacteria acne) is mainly effective for inflammatory acne, titration is used in the form of a gel of 2 ~ 5, but irritating and itchy and hot. Sulfur has a keratolytic effect and a sebum removal effect. It can be used for 2 to 10 years, but it is not suitable for cosmetics due to discoloration or odor of skin. One of the most widely used raw materials for cosmetics is salicylic acid, which acts as an exfoliating effect and is used for about 0.5 to 2.0. Clindamycin external ointment is the most effective topical antibiotic for topical application, and erythromycin, tetracycline, sulfonamide, etc. are used.

Currently used acne treatments are commonly used as medicines have side effects. In cosmetics, ginseng, burdock, rosemary extract, etc., which have a sebum inhibiting action, or vitamin B, etc., may be used to normalize sebum secretion to heal acne. In addition, the use of moisturizers and alpha-hydroxy acids (AHAs) to soften dead skin cells can help curb acne by promoting the release of sebum.

Until now, the evaluation aimed at alleviating acne has been carried out using a method of evaluating hyperkeratosis, controlling sebum secretion, and bactericidal power against acne bacteria using the above-described mechanism of action.

Accordingly, an object of the present invention is to prevent amino acid, sulfopeptide, vitamin B, chrysanthemum, in order to prevent normal keratinized disorders on the skin surface due to excessive sebum secretion by periodic biorhythms due to hormone imbalance. It is to provide a cosmetic composition for sebum control and anti-acne, characterized by containing 0.01 to 20 acinidyl, such as a mixture of xanthine, zinc salt.

The object of the present invention is to select the seven kinds of raw materials having antibacterial activity to investigate the antimicrobial effect and the antibacterial effect according to the acnidyl content after preparing the cosmetic composition containing the acnidyl subjects to 15 skin test of oily skin In order to find out the effects of sebum control and acne healing was achieved by examining the sebum sensitizing effect.

Hereinafter, the configuration and operation of the present invention.

The present invention comprises the steps of examining the antimicrobial power of the seven raw materials; Examining the antimicrobial effect according to the content of acnidyl; Preparing a cosmetic composition containing acnidyl; Investigating the sebum control effect of the cosmetic composition containing acnidyl; It consists of examining the acne healing effect of the cosmetic composition containing acnidyl.

Acnidyl used in the present invention is the sole material of the French Sero Institute and its composition is shown in Table 1.

Acnidyl Ingredients ingredient content Amino acid sulfopeptide niacinamide biotin pentanoxanthine steroid glycoside zinc salt ethanol 1 to 153 to 151 to 51 to 51 to 51 to 51 to 51 to 310 to 3020 to 80 [Unit] units; weight

The present invention will be described in detail, amino acids with sebum control function and sulfopeptide component and vitamin B component that inhibits fat formation, niacinamide, biotin, pentanol component and xanthine, plant origin steroid glycosides that give anti-inflammatory action, As a complex component that gives a synergy effect by combining an appropriate amount of zinc salt having a sebum control effect, a feature of the present invention is to add acnidyl to cosmetics, ie skins, lotions, creams, etc. in an appropriate ratio. Preferably it is 0.01-20.0 weight of acnidyl. It is not suitable because the effect is not sufficient when the acinidyl is added at 0.01 weight or less, and when the addition is more than 20.0 weight, the difference in the effect on the dose is not efficient and may cause irritation. Therefore, the content is preferably 0.01 to 20.0 wt. Depending on the stimulus or the optimum efficacy, the content ratio can be adjusted.

In addition, in order to prevent the occurrence of scalp on the skin during application, it does not generate scalp at the same time and contains 0.1 to 5 weight, preferably 0.5 to 5 weight, of hypoallergenic silicone oil and cetyl alcohol and stearyl alcohol. It is characterized by containing a cosmetic composition for the skin having a therapeutic effect in order to prevent acne prone to occur due to excessive sebum secretion.

Hereinafter, specific examples of the present invention will be described in detail with reference to Examples and Experimental Examples, but the scope of the present invention is not limited only to these Examples and Experimental Examples, and the content display unit of components in Examples and Experimental Examples is weight.

Example 1 Investigation of Antimicrobial Activity of Selected Raw Materials

In this embodiment, the raw material having an antimicrobial effect against acne bacteria was selected, and the propion bacterium Acne KCTC3314 strain was selected and poured into a petri dish. It was put up by micrometer. After incubation for 2 days at 37 ℃ anaerobic condition (BBL, Gaspak) was obtained by measuring the diameter of the inhibition (inhibition zone). Table 2 shows seven kinds of raw materials having antibacterial activity.

7 kinds of antibacterial raw materials division Characteristic Dilute solvent Acnidyl LS 9088 Amino acids, sulfopeptides, niacinamides, biotin, pentanol, xanthine, steroid glycosides, zinc salts, ethanol Distilled water Sebomine SB12 Lactoferin lacto peroxide Distilled water Rovisome Acne Sodium Salicylate triclosan Surfactants Irgasan DP300 Triclosan Alcohol Cosmacol EMI Tridecyl salicylate Distilled water 18β glycyretinate (glycyrrhetinic acid salt) Licorice root Distilled water Amaryl lipo LS4117 Trilosan salicylic acid Alcohol

As a result of the experiment, the bactericidal power of the seven selected acne bacteria having the antibacterial effect against acne is shown in Table 3.

Antimicrobial Effect of Each Raw Material division Characteristic Dilute solvent Inhibition zone diameter (mm) One 0.1 Acnidyl LS 9088 Amino acids, sulfopeptides, niacinamides, biotin, pentanol, xanthine, steroid glycosides, zinc salts, ethanol Distilled water 27 0 Sebomine SB12 Lactoferin, lacto peroxide Distilled water 0 0 Rovisome Acne Sodium Salicylate triclosan Surfactants 0 0 Irgasan DP300 Triclosan Alcohol 57 51 Cosmacol EMI Tridecyl salicylate Distilled water 0 0 18β glycyrrhetinate (glycyrrhetinic acid salt) Licorice root Distilled water 33 0 Amaryl lipo LS4117 Triclosan salicylic acid Alcohol 27 0

Examples 2-7: investigation of antimicrobial activity according to the acnidyl content

The results of the antimicrobial activity of the raw material itself and the results of the complex action when applied to the product may be different. In the present embodiment, in order to investigate the antimicrobial activity according to the acnidyl content, the oil phase component and the water phase component were completely dissolved up to 80 ° C. with the composition as shown in Table 4, and the aqueous phase and the oil phase were emulsified at 3000 rpm in a separate dissolution tank for 5 minutes. Thereafter, since the active ingredient may be destroyed at 50 ° C. or higher since it is weak in temperature, the mixture was cooled and degassed to 45 ° C., followed by addition of acinidyl, and finally cooled to 30 ° C. for aging.

Contents of Cosmetic Compositions with Different Acnidyl Contents Raw material Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Disodium EDTA Quantity Left Left Left Left Left Methyl paraben Quantity Left Left Left Left Left Glycerin 3.00 Left Left Left Left Left 1,3 Butylene Glycol 3.00 Left Left Left Left Left Xanthangum 0.05 Left Left Left Left Left Propyl paraben Quantity Left Left Left Left Left Ceto stearyl alcohol 2.50 Left Left Left Left Left Bees wax 0.50 Left Left Left Left Left Glyceryl stearate and PEG100 stearic acid 1.50 Left Left Left Left Left Neopentyl glycol dicaprate 4.00 Left Left Left Left Left Squalene 3.00 Left Left Left Left Left Cyclomethicone 2.00 Left Left Left Left Left Fragrance Quantity Left Left Left Left Left Ethanol 2.00 Left Left Left Left Left Acnidyl 0.01 0.10 1.00 5.00 10.00 20.00 Water to 100 Left Left Left Left Left

As a result of the experiment, the anti-sebum secretion and the antibacterial action against the bacterial factor and the sebum control action as shown in Table 4, when used in combination with 0.01 to 20.0 by weight of acnidyl, inhibiting excessive sebum secretion and antibacterial against bacteria It was found that the effect was excellent. More preferably 0.5 to 10.0 weight of acnidyl is appropriate. As shown in Table 5, the cosmetic composition clearly shows the antimicrobial effect was found to be the case of a large amount of acnidyl having excellent bactericidal power against bacteria. However, when it contained more than 5 weights, a slightly gentle curve was shown. The higher the content of acnidyl, the lower the stability. Preferably, the weight-containing formulation was found to be stable.

Antimicrobial Effect According to the Content of Acnidil division Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Acnidyl content 0.01 0.10 1.00 5.00 10.00 20.00 Inhibition zone diameter (mm) 2 5 20 44 58 61

Example 8 and Comparative Example 1 Preparation of Cosmetic Composition Containing Acnidyl Component

As in the manufacturing method of Examples 2-7, the oil phase component and the water phase component were completely dissolved up to 80 ° C., respectively, and the water phase and oil phase were emulsified at 3000 rpm in a separate dissolution tank for 5 minutes, and therefore, the active ingredient was above 50 ° C. Since it may be destroyed, the mixture was cooled and degassed to 45 ° C., and then aged to 30 ° C. by adding acnidyl. Each raw material was prepared by the composition shown in Table 6.

Ingredients of each raw material Raw material Example 8 Raw material Comparative Example 1 Disodium EDTA 0.02 Disodium EDTA 0.02 Methyl paraben 0.10 Methyl paraben 0.10 Glycerin 3.00 Glycerin 3.00 1,3 Butylene Glycol 3.00 1,3 Butylene Glycol 3.00 Xanthangum 0.05 Xanthanum 0.05 Propyl paraben 0.10 Propyl paraben 0.10 Ceto stearyl alcohol 2.50 Ceto stearyl alcohol 2.50 Bees wax 0.50 Bees wax 0.50 Glyceryl stearate and PEG100 stearic acid 1.50 Glyceryl stearate and PEG100 stearic acid 1.50 Neopentyl glycol dicaprate 4.00 Neopentyl glycol dicaprate 4.00 Squalene 3.00 Squalene 3.00 Cyclomethicone 2.00 Cyclomethicone 2.00 Fragrance 0.122 Fragrance 0.122 Ethanol 2.00 Ethanol 2.00 Acnidyl 5.00 Acnidyl - Water to 100 Water to 100

Experimental Example 1: Examination of sebum control effect of the cosmetic composition containing the acnidyl component 5

Subject Selection

Fifteen subjects with oily skin showing excess sebum between the ages of 18 and 28 years were recruited. They should be normal skin at least a month before, with no acne-like allergic reactions. At least 6 months of age should not have been treated with retinoid scleroderma and the final 5 patients were selected after frequent exposure to UV light for at least one month.

Keratin measurement

Measured with Sebutape (Cuderm Corp. Dallas, Texas) to identify where sebum is secreted and where it is absent as the difference in shade. The number of points was checked to confirm the presence of acne.

product

Placebo cream: cream without acnidyl 5 (Comparative Example 1)

Active LS9088 Cream: Cream with Acnidil 5 (Example 8)

Both the placebo and the active cream have no stability problems and are manufactured with a good feel and non stickiness.

apply

The subject's face was divided in half and applied twice a day for 4 weeks. Five of the subjects had active cream applied on the right side and the other five had active cream applied on the left side.

The cosmetic composition for skin prepared in Example 8 was measured for the sensitizing effect of sebum secretion in a person with oily skin having a lot of sebum secretion. The sebum distribution on sebutape for 28 days was measured in 10 people who suffered from excessive sebum secretion and compared with before and after application.

Sebum distribution comparison Date Product Day 0 Day 28 Day 0 / Day 28 Placebo cream 5261.2 4913.8 -7 (NS) Active cream 5927.4 3926.8 -34 [Note] NS: No significant difference

After 28 days of application, Sebutape showed no significant difference in placebo cream but active cream decreased by 34. In other words, applying the cream containing the active ingredient under the same conditions showed that it is much more effective.

Experimental Example 2: Investigation of Acne Healing Effect of the Cosmetic Composition Containing Acnidyl

The cosmetic composition for skin prepared in Example 8 was measured for the sensitizing effect of sebum secretion in a person having oily skin. Ten subjects with excessive sebum secretion were tested. Excess sebum secretion causes acne soon, so as to compare the before and after application by measuring the number of spots on Sebutape during 28 days, as shown in Table 8.

Comparison of sebum secretion effect Date Product Day 0 Day 28 Day 0 / Day 28 Placebo cream 307.5 297.7 -3 (NS) Active cream 347 255.5 -26 [Note] NS: No significant difference

After 28 days of application, the number of spots on Sebutape showed little difference in placebo cream, but active cream decreased by 26. In other words, applying the cream containing the active ingredient under the same conditions showed that the effect is much greater.

The cosmetic composition of the present invention is characterized in that it contains acnidyl, which is a mixture of amino acid, sulfuric acid, vitamin B, xanthine, zinc salt, etc., having a function of sebum control, as described through the above examples and experimental examples. When applied, it is a very useful inventor in the cosmetic industry because it has an excellent effect on preventing and relieving acne by improving the skin prone to acne due to excessive secretion of sebum due to asymmetrical action of astringent and sebum secretion and excretion control. will be.

Claims (1)

Sebum control and anti-acne cosmetic composition characterized by containing 0.01 to 20.0 by weight of acnidyl (Acnidyl LS9088) component. (However, the acinidyl is 1 to 15 weights of amino acids, 3 to 15 weights of sulfopeptides, 1 to 5 weights of niacinamide, 1 to 5 weights of biotin, 1 to 5 weights of pentanol, 1 to 5 weights of xanthine, steroid glycoside 1 ~ 5 weight, zinc salt 1-3 weight, 10-30 weight of ethanol, 20-80 weight of purified water.)