KR20010029118A - a formula for making antibiotic of animal - Google Patents

Abstract

PURPOSE: A method for manufacturing an animal antibiosis in feed is provided to improve the prevention and treatment of various diseases by feeding Enrofloxacin put in the feed. CONSTITUTION: Enrofloxacin 5% and grain starch 95% are mixed and kneaded with water in a kneading bowl. The paste is put into an extruder and is transported by a transferring screw. The paste is extruding after cooking by 130deg.C heat when passing through a heating part installed on the outer circumference of the front end of the extruder. The extruded paste is cooled by the compulsory ventilation. The cooled paste is cut into grain size. The cut paste is ripened by humidifying within 80% humidity for 8 hours. The ripened paste is lyophilized at -24deg.C for 24 hours.

Description

Formulation method for making antibiotic antibiotics {a formula for making antibiotic of animal}

The present invention relates to a method for producing animal antibiotics for feed, and in particular, the antibiotic enrofloxacin, which is used as a therapeutic agent for livestock, is contained in viscous grain starch, which is a feed for livestock, together with the feed of wet livestock. No odor from antibiotics even when fed, so that animals can eat antibiotics with feed without any rejection reactions, and thus can effectively prevent and treat various diseases caused by livestock. It is about.

Cattle are easily susceptible to various kinds of diseases, and if they are infected, the infection rate is high, so they can easily spread the disease to other livestock around them. .

As described above, there are two methods for preventing the disease from being mixed with antibiotics by injecting antibiotics into the feed and feeding the animals with the feed.

However, the first method, injection, means that antibiotics are administered to livestock (pigs) because the nerves are sensitive and stresses a lot during the administration of the injections. Due to the stress to be received every time there is a disadvantage that the normal development is not achieved, and also in order to administer antibiotics to a large amount of livestock is a situation that is rarely used due to a lot of time and economic loss.

This relationship reduces the waste of time and economic losses by incorporating antibiotics into livestock feed, allowing livestock to eat antibiotics with feed, resulting in a relatively high incidence of disease in pigs. If the smell is relatively sensitive compared to other livestock, and antibiotics are mixed in the feed, the smell from the antibiotic components of the antibiotic prevents the food from being fed again.

The antibiotic used here as a therapeutic agent, Enrofloxacin, has gradually developed the quinolone antimicrobial agent nilidixic acid (substitute N with CH, insert F, replace methyl group with Piperazinyl, Fluoroquinolone-based advanced chemotherapy agent is a kind of antibacterial agent with wide antibacterial range and excellent therapeutic effect.

Enrofloxacin is sensitive to the treatment of susceptible bacteria and especially swine diseases such as digestive organs (e. Rhinitis), and it is a therapeutic agent that has excellent efficacy in preventing and treating various diseases such as dondak poison, Glaser's disease, edema disease, MMA (non-fatal syndrome), meningitis, and multiple abscess.

Due to the universal adoption of the second method of administering antibiotics without stressing livestock at all, the Enrofloc, which is an antibiotic in common grains, is used to prevent the antibiotic from smelling at all. Products mixed with reaper and other excipients are mixed in the feed to prevent and treat various diseases as the livestock feed on antibiotics with the feed. The grains are weak in water, so the water mixed in the feed easily penetrates the grains. As swelling causes antibiotics contained in grains to flow out with water, pigs with sensitive tastes and smells can easily feel the smell of antibiotics, so they refuse to feed and thus do not feed antibiotics. I can't do it.

Therefore, an object of the present invention is to provide a high-viscosity grain starch that can be formulated antibiotic antibiotics to prevent and treat diseases of livestock, so that starch is not easily swollen in water by the viscosity of grain starch Even though some swell due to strong viscosity, mixed antibiotics are not discharged from starch, so pigs can not easily feed antibiotics because they do not feel the peculiar smell of antibiotics. In addition, since starch is used as a substitute for feed, it is possible to reduce the use of feed, thereby reducing the economic loss.

Hereinafter, the production process of the therapeutic agent using the grain starch of the present invention will be described with reference to Examples.

First process (mixing and kneading process)

95% of starch finely ground grains (sweet potatoes, potatoes, corn, etc.) selected according to the purpose of use is mixed with an antibiotic enrofloxacin at a rate of 5%, and then kneaded together with an appropriate amount of water by a kneader. Make dough by letting it.

When explaining a specific embodiment for this, when the dough kneaded by the kneader is 1 Kg, the ratio of the antibiotic 50g to the grain starch 950g and the water by about 0.04ℓ is to be made.

2nd process (compression molding process)

The dough kneaded through the first process is put into a compression molding machine to be compressed while being forcibly compressed by a transfer screw, and the dough to be conveyed while being compressed as described above is installed at the outer periphery of the tip of the molding machine. The dough is cooked by a temperature of about 130 ° C. heated by the heater part when passing through the part.

The dough kneaded while passing through the heater unit is pushed by the kneading material which is continuously compressed and then passed through a molding plate provided at the tip of the molding machine, that is, a plurality of through holes having a diameter of about 0.5 mm, so that the kneading material is uniform. It is extruded into a long strip of thin thickness.

3rd process (cutting and maturing process)

Through the second process, the molded article having a thin thickness and the long molded article is cooled by the air blown from the blower to cool the increased heat, and the molded article cooled by the blower is cut into small pieces with a cutter. The granules are cut to the size of granules, and the granulated granules cut by the cutter are moisturized for about 8 hours in a humidity of about 80% to allow the moldings to mature.

4th process (freezing and drying process)

After the third step, the small granulated molded product is aged for about 24 hours in a freezer maintained at a temperature of minus 24 ° C, and then frozen for about 24 hours, and then sprayed onto the frozen molded product due to freezing. After the drying process, the water in the molding is dried to complete the drying process.

Antibiotics prepared through the manufacturing method as described above is to feed the feed antibiotics to feed the animals when feeding the livestock, about 95% of the antibiotics having a small grain size is made of starch of grain Since it can be used as a livestock feed can reduce the amount of commonly used feed can reduce the economic burden, the high viscosity of the grain starch does not easily swell in water even when contacted with water Of course, even if the grain starch swells with water after a certain period of time, the antibiotics contained in the starch, that is, enlofloxacin does not flow out from the starch as the starch swells finely due to the strong viscosity of the starch. The unique odor does not radiate to the outside, so even the pigs with sensitive tastes and smells feel the smell It is not easy to feed a certain amount of antibiotics with feed, so that antibiotics are administered into the body without stressing pigs, which can prevent various diseases in advance and also effectively treat diseases. There is.

Claims (1)

A mixing and kneading process of kneading together an appropriate amount of water with a suitable amount of water in a state where 95% of starch finely ground various grains is mixed with an antibiotic enrofloxacin at a rate of 5%; The dough kneaded through the above process is put into a compression molding machine and is forcibly compressed by a conveying screw to be conveyed. The dough is heated to the heater part when the dough passes through the heater part installed at the outer periphery of the molding machine. It is cooked by the temperature of ℃, the compression molding process for the molded dough is extruded to a thin thickness while passing through a forming plate having a plurality of through holes having a fine diameter; Through the above process, forced air is blown to the molded product having a thin thickness and long, to cool the remaining heat of the molding, and to cut the cooled cooling molding to the size of small grains, A aging step of aging the molded granules cut by the moistening for about 8 hours in a humidity of about 80%; The antibiotic of the feed animal, characterized in that formed by the freezing, drying process that freezes, dried for about 24 hours at minus 24 ℃ for a small granular molded product completed through the above process.