KR20010024836A - 자기 반응성 조성물 - Google Patents
자기 반응성 조성물 Download PDFInfo
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- KR20010024836A KR20010024836A KR1020007007485A KR20007007485A KR20010024836A KR 20010024836 A KR20010024836 A KR 20010024836A KR 1020007007485 A KR1020007007485 A KR 1020007007485A KR 20007007485 A KR20007007485 A KR 20007007485A KR 20010024836 A KR20010024836 A KR 20010024836A
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/003,286 US6200547B1 (en) | 1994-01-26 | 1998-01-06 | Magnetically responsive compositions for carrying biologically active substances and methods of production and use |
| US09/003,286 | 1998-01-06 | ||
| PCT/US1999/000243 WO1999034779A1 (en) | 1998-01-06 | 1999-01-06 | Magnetically responsive composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20010024836A true KR20010024836A (ko) | 2001-03-26 |
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| KR1020007007485A Ceased KR20010024836A (ko) | 1998-01-06 | 1999-01-06 | 자기 반응성 조성물 |
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| Country | Link |
|---|---|
| US (1) | US6200547B1 (enExample) |
| EP (1) | EP1043975A4 (enExample) |
| JP (1) | JP2002500177A (enExample) |
| KR (1) | KR20010024836A (enExample) |
| CN (1) | CN1348362A (enExample) |
| AU (1) | AU744205B2 (enExample) |
| BR (1) | BR9906786A (enExample) |
| CA (1) | CA2317019C (enExample) |
| IL (2) | IL137033A0 (enExample) |
| NZ (1) | NZ505408A (enExample) |
| WO (1) | WO1999034779A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6482436B1 (en) * | 1993-01-29 | 2002-11-19 | Ferx Incorporated | Magnetically responsive composition |
| ATE510855T1 (de) * | 2000-03-06 | 2011-06-15 | Univ Kentucky Res Found | Verwendung eines antikörpers oder eines immunotoxins, der bzw. das selektiv an cd123 bindet zur beeinträchtigung hämatologischer krebs-vorläuferzellen |
| US7090636B2 (en) * | 2000-03-31 | 2006-08-15 | Fe Rx Incorporated | Permanent magnet keeper-shield assembly |
| US6488615B1 (en) | 2000-03-31 | 2002-12-03 | Ferx Incorporated | Permanent magnet keeper-shield assembly |
| US7863011B2 (en) * | 2000-05-10 | 2011-01-04 | Signe Biopharma, Inc. | Screening method for predicting susceptibility to breast cancer |
| US8119138B2 (en) * | 2000-05-10 | 2012-02-21 | Signe Biopharma Inc. | Anti-estrogen and immune modulator combinations for treating breast cancer |
| US20030072812A1 (en) | 2001-05-10 | 2003-04-17 | Sirbasku David A | Breast cancer eradication program |
| MXPA02011092A (es) | 2000-05-10 | 2004-08-19 | David A Sirbasku | Composiciones y metodos para demostrar la regulacion del sistema inmune secretor del crecimiento de la celula de cancer que responde a la hormona esteroidea. |
| US6921283B2 (en) * | 2001-08-27 | 2005-07-26 | Trompeter Electronics, Inc. | BNC connector having visual indication |
| US6679827B2 (en) * | 2001-10-11 | 2004-01-20 | Robert E. Sandstrom | Magnetic field enhancement of tumor treatment |
| WO2003042404A2 (en) * | 2001-11-13 | 2003-05-22 | Sirbasku David A | Breast cancer eradication program |
| US7249604B1 (en) * | 2002-05-10 | 2007-07-31 | Vasmo, Inc. | Medical devices for occlusion of blood flow |
| CN100384475C (zh) * | 2002-10-29 | 2008-04-30 | 德州科隆载体研究所 | 磁引导抗癌药剂的制备方法 |
| EP1631259A4 (en) * | 2002-12-18 | 2006-08-02 | Hough Ear Inst | OTOLOGICAL NANOTECHNOLOGY |
| US20050261763A1 (en) * | 2003-04-08 | 2005-11-24 | Xingwu Wang | Medical device |
| US20050278020A1 (en) * | 2003-04-08 | 2005-12-15 | Xingwu Wang | Medical device |
| US20050025797A1 (en) * | 2003-04-08 | 2005-02-03 | Xingwu Wang | Medical device with low magnetic susceptibility |
| US20050244337A1 (en) * | 2003-04-08 | 2005-11-03 | Xingwu Wang | Medical device with a marker |
| US20050240100A1 (en) * | 2003-04-08 | 2005-10-27 | Xingwu Wang | MRI imageable medical device |
| US20050155779A1 (en) * | 2003-04-08 | 2005-07-21 | Xingwu Wang | Coated substrate assembly |
| US7344491B1 (en) | 2003-11-26 | 2008-03-18 | Nanobiomagnetics, Inc. | Method and apparatus for improving hearing |
| US7723311B2 (en) * | 2003-06-18 | 2010-05-25 | Nanobiomagnetics, Inc. | Delivery of bioactive substances to target cells |
| US8651113B2 (en) * | 2003-06-18 | 2014-02-18 | Swr&D Inc. | Magnetically responsive nanoparticle therapeutic constructs and methods of making and using |
| DE10359252A1 (de) * | 2003-12-17 | 2005-07-28 | Siemens Ag | Navigierte Wärmebehandlung von Tumoren mit enzymumhüllten Eisenpartikeln |
| US20070027532A1 (en) * | 2003-12-22 | 2007-02-01 | Xingwu Wang | Medical device |
| US8562505B2 (en) * | 2004-02-20 | 2013-10-22 | The Children's Hospital Of Philadelphia | Uniform field magnetization and targeting of therapeutic formulations |
| US7846201B2 (en) * | 2004-02-20 | 2010-12-07 | The Children's Hospital Of Philadelphia | Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex |
| US9028829B2 (en) * | 2004-02-20 | 2015-05-12 | The Children's Hospital Of Philadelphia | Uniform field magnetization and targeting of therapeutic formulations |
| US20070100457A1 (en) * | 2004-03-04 | 2007-05-03 | Hyde Edward R Jr | Paramagnetic liquid interface |
| GB0405552D0 (en) * | 2004-03-12 | 2004-04-21 | Magnet Attraction Ltd | Methods for the targetted delivery of biological molecules |
| US20070231393A1 (en) * | 2004-05-19 | 2007-10-04 | University Of South Carolina | System and Device for Magnetic Drug Targeting with Magnetic Drug Carrier Particles |
| US20080124400A1 (en) * | 2004-06-24 | 2008-05-29 | Angiotech International Ag | Microparticles With High Loadings Of A Bioactive Agent |
| CN1733314A (zh) * | 2004-08-11 | 2006-02-15 | 张阳德 | 半乳糖化白蛋白磁性阿霉素纳米粒的制备方法 |
| WO2007035871A1 (en) * | 2005-09-21 | 2007-03-29 | Massachusetts Institute Of Technology | Systems and methods for tuning properties of nanoparticles |
| US20070255086A1 (en) * | 2006-04-26 | 2007-11-01 | Nehls Robert J | Medical Device Including Magnetic Particles |
| WO2008127735A1 (en) | 2007-04-13 | 2008-10-23 | Stemline Therapeutics, Inc. | Il3ralpha antibody conjugates and uses thereof |
| EP2205225A4 (en) * | 2007-10-03 | 2013-09-18 | Jncasr Bangalore | INTRINSIC FLUORESCENCE CARBON NANOSPHERES AND PROCESS FOR PRODUCING THE SAME |
| US20090169484A1 (en) | 2007-12-28 | 2009-07-02 | Ihi Corporation | Iron-salen complex |
| JP2009274962A (ja) * | 2008-05-12 | 2009-11-26 | Yoshihiro Ishikawa | 鉄サレン錯体、磁性を有する薬剤、薬剤の誘導システム、並びに磁気検出装置 |
| WO2010058280A1 (ja) | 2008-11-20 | 2010-05-27 | 株式会社Ihi | 自己磁性金属サレン錯体化合物 |
| US10398668B2 (en) | 2010-10-19 | 2019-09-03 | The Board Of Regents Of The University Of Oklahoma | Glutamate treatment of cardiovascular disorders |
| US8740872B2 (en) | 2010-10-19 | 2014-06-03 | The Board Of Regents Of The University Of Oklahoma | Magnetically-targeted treatment for cardiac disorders |
| US9744235B2 (en) | 2010-10-19 | 2017-08-29 | The Board Of Regents Of The University Of Oklahoma | Treatment of cardiovascular disorders with targeted nanoparticles |
| SG192062A1 (en) | 2010-12-21 | 2013-08-30 | Ihi Corp | Metal-salen complex compound and production method for same |
| JP2012176905A (ja) * | 2011-02-25 | 2012-09-13 | Ihi Corp | 金属サレン錯体化合物 |
| WO2025118073A1 (en) * | 2023-12-04 | 2025-06-12 | Rocket Science Health Corp. | Magnetic formulations for biomarker sampling and enhanced drug delivery |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3718594A (en) | 1970-11-30 | 1973-02-27 | Eastman Kodak Co | Method of preparing magnetically responsive carrier particles |
| US4106488A (en) | 1974-08-20 | 1978-08-15 | Robert Thomas Gordon | Cancer treatment method |
| US4345588A (en) | 1979-04-23 | 1982-08-24 | Northwestern University | Method of delivering a therapeutic agent to a target capillary bed |
| US4247406A (en) | 1979-04-23 | 1981-01-27 | Widder Kenneth J | Intravascularly-administrable, magnetically-localizable biodegradable carrier |
| US4331654A (en) | 1980-06-13 | 1982-05-25 | Eli Lilly And Company | Magnetically-localizable, biodegradable lipid microspheres |
| US4501726A (en) | 1981-11-12 | 1985-02-26 | Schroeder Ulf | Intravascularly administrable, magnetically responsive nanosphere or nanoparticle, a process for the production thereof, and the use thereof |
| US4652257A (en) | 1985-03-21 | 1987-03-24 | The United States Of America As Represented By The Secretary Of The Navy | Magnetically-localizable, polymerized lipid vesicles and method of disrupting same |
| US4849209A (en) | 1985-06-07 | 1989-07-18 | Cadema Medical Products, Inc. | Treatment of arthritis, including rheumatoid arthritis with 166 Holmium radionuclide |
| US4818614A (en) | 1985-07-29 | 1989-04-04 | Shiseido Company Ltd. | Modified powder |
| US4690130A (en) | 1985-12-19 | 1987-09-01 | Mirell Stuart G | Electromagnetic therapy control system |
| US4871716A (en) | 1986-02-04 | 1989-10-03 | University Of Florida | Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof |
| JPH01122037U (enExample) | 1988-02-12 | 1989-08-18 | ||
| SU1722256A3 (ru) | 1989-11-02 | 1992-03-23 | Viktor A Volkonskij | Cпocoб пoлучehия maгhиtoупpabляemoй диcпepcии |
| AU6165394A (en) * | 1993-01-29 | 1994-08-15 | Magnetic Delivered Therapeutics, Inc. | Magnetically responsive composition for carrying biologically active substances and methods of production and use |
| US5776925A (en) * | 1996-01-25 | 1998-07-07 | Pharmacyclics, Inc. | Methods for cancer chemosensitization |
| US5827533A (en) * | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
-
1998
- 1998-01-06 US US09/003,286 patent/US6200547B1/en not_active Expired - Fee Related
-
1999
- 1999-01-06 AU AU20279/99A patent/AU744205B2/en not_active Ceased
- 1999-01-06 JP JP2000527230A patent/JP2002500177A/ja active Pending
- 1999-01-06 CA CA002317019A patent/CA2317019C/en not_active Expired - Fee Related
- 1999-01-06 WO PCT/US1999/000243 patent/WO1999034779A1/en not_active Ceased
- 1999-01-06 EP EP99900771A patent/EP1043975A4/en not_active Withdrawn
- 1999-01-06 IL IL13703399A patent/IL137033A0/xx unknown
- 1999-01-06 IL IL13703398A patent/IL137033A/en active IP Right Grant
- 1999-01-06 NZ NZ505408A patent/NZ505408A/xx unknown
- 1999-01-06 BR BR9906786-2A patent/BR9906786A/pt not_active Application Discontinuation
- 1999-01-06 CN CN99803728A patent/CN1348362A/zh active Pending
- 1999-01-06 KR KR1020007007485A patent/KR20010024836A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU744205B2 (en) | 2002-02-21 |
| NZ505408A (en) | 2003-04-29 |
| WO1999034779A1 (en) | 1999-07-15 |
| IL137033A (en) | 2005-12-18 |
| EP1043975A1 (en) | 2000-10-18 |
| IL137033A0 (en) | 2001-06-14 |
| BR9906786A (pt) | 2000-10-17 |
| CA2317019A1 (en) | 1999-07-15 |
| CN1348362A (zh) | 2002-05-08 |
| AU2027999A (en) | 1999-07-26 |
| EP1043975A4 (en) | 2007-05-02 |
| CA2317019C (en) | 2003-10-14 |
| US6200547B1 (en) | 2001-03-13 |
| JP2002500177A (ja) | 2002-01-08 |
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