KR20000053007A - 비만(ｏｂ) 단백질의 작용을 조절하는 화합물의 검출 방법 - Google Patents

비만(ｏｂ) 단백질의 작용을 조절하는 화합물의 검출 방법 Download PDF

Info

Publication number
KR20000053007A
KR20000053007A KR1019990703890A KR19997003890A KR20000053007A KR 20000053007 A KR20000053007 A KR 20000053007A KR 1019990703890 A KR1019990703890 A KR 1019990703890A KR 19997003890 A KR19997003890 A KR 19997003890A KR 20000053007 A KR20000053007 A KR 20000053007A
Authority
KR
South Korea
Prior art keywords
cell line
protein
derived
cell
compound
Prior art date
Application number
KR1019990703890A
Other languages
English (en)
Korean (ko)
Inventor
리 제임스 비레이
Original Assignee
피터 기딩스
스미스클라인비이참피이엘시이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9622848.1A external-priority patent/GB9622848D0/en
Priority claimed from GBGB9622850.7A external-priority patent/GB9622850D0/en
Priority claimed from GBGB9622869.7A external-priority patent/GB9622869D0/en
Priority claimed from GBGB9622847.3A external-priority patent/GB9622847D0/en
Priority claimed from GBGB9622870.5A external-priority patent/GB9622870D0/en
Priority claimed from GBGB9622866.3A external-priority patent/GB9622866D0/en
Priority claimed from GBGB9622851.5A external-priority patent/GB9622851D0/en
Priority claimed from GBGB9622867.1A external-priority patent/GB9622867D0/en
Priority claimed from GBGB9622849.9A external-priority patent/GB9622849D0/en
Priority claimed from GBGB9622865.5A external-priority patent/GB9622865D0/en
Priority claimed from GBGB9622868.9A external-priority patent/GB9622868D0/en
Application filed by 피터 기딩스, 스미스클라인비이참피이엘시이 filed Critical 피터 기딩스
Publication of KR20000053007A publication Critical patent/KR20000053007A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1019990703890A 1996-11-01 1997-10-30 비만(ｏｂ) 단백질의 작용을 조절하는 화합물의 검출 방법 KR20000053007A (ko)

Applications Claiming Priority (22)

Application Number Priority Date Filing Date Title
GBGB9622850.7A GB9622850D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622869.7A GB9622869D0 (en) 1996-11-01 1996-11-01 Novel method
GB9622867.1 1996-11-01
GBGB9622847.3A GB9622847D0 (en) 1996-11-01 1996-11-01 Novel method
GB9622866.3 1996-11-01
GBGB9622870.5A GB9622870D0 (en) 1996-11-01 1996-11-01 Novel method
GB9622869.7 1996-11-01
GB9622865.5 1996-11-01
GB9622849.9 1996-11-01
GB9622868.9 1996-11-01
GBGB9622848.1A GB9622848D0 (en) 1996-11-01 1996-11-01 Novel method
GB9622851.5 1996-11-01
GBGB9622866.3A GB9622866D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622851.5A GB9622851D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622867.1A GB9622867D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622849.9A GB9622849D0 (en) 1996-11-01 1996-11-01 Novel method
GBGB9622865.5A GB9622865D0 (en) 1996-11-01 1996-11-01 Novel method
GB9622870.5 1996-11-01
GB9622848.1 1996-11-01
GB9622850.7 1996-11-01
GBGB9622868.9A GB9622868D0 (en) 1996-11-01 1996-11-01 Novel method
GB9622847.3 1996-11-01

Publications (1)

Publication Number Publication Date
KR20000053007A true KR20000053007A (ko) 2000-08-25

Family

ID=27581686

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019990703890A KR20000053007A (ko) 1996-11-01 1997-10-30 비만(ｏｂ) 단백질의 작용을 조절하는 화합물의 검출 방법

Country Status (13)

Country Link
EP (1) EP0951564A1 (fr)
JP (1) JP2001503982A (fr)
KR (1) KR20000053007A (fr)
AR (1) AR010262A1 (fr)
AU (1) AU4789297A (fr)
CA (1) CA2270431A1 (fr)
CZ (1) CZ149999A3 (fr)
IL (1) IL129685A0 (fr)
NO (1) NO992107L (fr)
NZ (1) NZ335489A (fr)
PL (1) PL333187A1 (fr)
TR (1) TR199900963T2 (fr)
WO (1) WO1998020158A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293533B1 (it) * 1997-07-14 1999-03-01 Angeletti P Ist Richerche Bio Metodo per la selezione di molecole in grado di mimare, inibire o potenziare gli effetti della interazione tra leptina e cellule che
GB9814199D0 (en) * 1998-06-30 1998-08-26 Univ Buckingham Novel method
EP1101112B1 (fr) * 1998-07-28 2004-10-06 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Induction de genes mediee par la leptine
GB9828087D0 (en) * 1998-12-18 1999-02-17 Smithkline Beecham Plc Novel method
EP1612221A3 (fr) 2000-05-22 2008-07-23 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Piège à interaction basé sur un récepteur
GB0019327D0 (en) * 2000-08-08 2000-09-27 Buchanan Baillie Hamilton Paul Slimming system
EP1812038A1 (fr) 2004-11-18 2007-08-01 VIB vzw Domaine de fibronectine iii servant d'antagonistes de recepteurs de la leptine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643748A (en) * 1994-09-14 1997-07-01 Progenitor, Inc. HU-B1.219, a novel human hematopoietin receptor
WO1996029405A2 (fr) * 1995-03-20 1996-09-26 Ligand Pharmaceuticals Incorporated MODULATEURS DU GENE ob ET PROCEDES DE CRIBLAGE A CET EFFET
US5712094A (en) * 1995-03-27 1998-01-27 Ligand Pharmaceuticals, Inc. Methods for detecting modulators of cytokine action
CA2222409A1 (fr) * 1995-05-30 1996-12-05 Smithkline Beecham P.L.C. Procede de detection de composes modulant les effets de la proteine ob
CA2252443A1 (fr) * 1996-04-22 1997-10-30 Merck & Co., Inc. Dosage de la leptine

Also Published As

Publication number Publication date
IL129685A0 (en) 2000-02-29
NZ335489A (en) 2001-01-26
TR199900963T2 (xx) 1999-08-23
CZ149999A3 (cs) 1999-10-13
NO992107L (no) 1999-06-30
WO1998020158A1 (fr) 1998-05-14
AU4789297A (en) 1998-05-29
JP2001503982A (ja) 2001-03-27
PL333187A1 (en) 1999-11-22
EP0951564A1 (fr) 1999-10-27
CA2270431A1 (fr) 1998-05-14
AR010262A1 (es) 2000-06-07
NO992107D0 (no) 1999-04-30

Similar Documents

Publication Publication Date Title
Murphy et al. Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the nurr1/nur77 subfamily of nuclear receptors
Martin et al. A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I
Brockman et al. PRL activates the cyclin D1 promoter via the Jak2/Stat pathway
Skorski et al. C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis
Ventura et al. Dynorphin gene expression and release in the myocardial cell.
WO2002087306A2 (fr) Bioanalyse a haut rendement basee sur des cellules, permettant de surveiller l'activite du canal sodique et de decouvrir des composes modulant la sensation de gout sale
Oster et al. Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression
WO2003027634A2 (fr) Identification de molecules modulatrices au moyen de promoteurs inductibles
Brasier et al. Synergistic enhansons located within an acute phase responsive enhancer modulate glucocorticoid induction of angiotensinogen gene transcription
Chattopadhyay et al. Extracellular calcium-sensing receptor induces cellular proliferation and activation of a nonselective cation channel in U373 human astrocytoma cells
KIM et al. Angiotensin II-responsive element is the insulin-responsive element in the adipocyte fatty acid synthase gene: role of adipocyte determination and differentiation factor 1/sterol-regulatory-element-binding protein 1c
WO1998003634A1 (fr) Procede d'identification d'agents vasoprotecteurs
Gadeau et al. Induction of cell cycle‐dependent genes during cell cycle progression of arterial smooth muscle cells in culture
Rydziel et al. Cortisol represses insulin-like growth factor II receptor transcription in skeletal cell cultures
AU715215B2 (en) Method for the detection of compounds that modulate the effects of the obese protein
KR20000053007A (ko) 비만(ｏｂ) 단백질의 작용을 조절하는 화합물의 검출 방법
Li et al. Transcriptional and translational regulation of angiotensin II type 2 receptor by angiotensin II and growth factors
Clifford et al. Dominant negative signal transducer and activator of transcription 2 (STAT2) protein: stable expression blocks interferon α action in skin squamous cell carcinoma cells
Hershman et al. Cell-cell contact between adult rat cardiac myocytes regulates Kv1. 5 and Kv4. 2 K+ channel mRNA expression
Vandenbergh et al. Chromatin structure as a molecular marker of cell lineage and developmental potential in neural crest-derived chromaffin cells
WO1993022331A9 (fr) Crabp-i et crabp-ii humaines
US20030224456A1 (en) Method for the detection of compounds that modulate the effects of the obese (OB) protein
MX2007014221A (es) Metodo para identificar compuestos que modulan la interaccion del receptor de androgeno con beta-catenina.
Shimokawa et al. Extracellular H+ stimulates the expression of c-fos/c-jun mRNA through Ca2+/calmodulin in PC12 cells
White et al. Identification of leptin-induced transcripts in the mouse hypothalamus.

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid