KR19980049252A - Wipes with bathroom fungicides - Google Patents

Abstract

The present invention is a fungus that resides in bathrooms, toilets and other places by incorporating fungicides of 3-iodo-2-propynyl butyl carbamate or 2- (4-thiazolyl) -benzimidazole and ethanol in non-woven fabrics or pulp. The present invention relates to a wet tissue composition containing a fungicide and a disinfectant which removes and sterilizes yeast and continuously prevents the regeneration of molds.

Description

[Name of invention]

Wipes with bathroom fungicides

Detailed description of the invention

[Purpose of invention]

The present invention relates to a wet tissue containing a disinfectant for bathroom mold removal. In more detail, the present invention relates to 3-iodo-2-propynyl bytyl carbamate of formula (I) and 2- (4-thia) of formula (II) By containing 2- (4-thiazolyl) -benzimidazole in non-woven fabrics or pulp, it can be used in wet tissues that can effectively eliminate mold and by-products and prevent mold development in toilets, bathrooms and other places. It is about.

[Technical Field to which the Invention belongs and Prior Art in the Field]

The fungus, commonly referred to, belongs to the taxonomic fungus (Eumycetes), which has spores in the form of powder colored by the naked eye, and the mycelium is in the shape of a hand, a feather or a broom. . There are about 5,100 genera and 45,000 species of fungi distributed in nature. Fungi often develop and format in humid summers, and are often found in confined spaces such as wet toilets, bathrooms, and shoe racks.

Spores and mycelia of the fungus are suspended in the air in the form of invisible fine particles, causing various respiratory diseases and allergies in humans. In addition, when contaminated on specific areas, skin diseases, housewives eczema, etc. cause human suffering. Fungi have strong growth and vitality, and if they have adequate moisture and nutrients, they grow rapidly, create spores in unfavorable conditions, float in the air, move to conditions suitable for growth, and quickly resume their growth activities. Therefore, it is known that it is very difficult to remove mold and prevent the occurrence of mold due to the characteristics of the mold.

In the past, attempts to solve the above problems by lowering the moisture content of the environment using a moisture remover. These methods are limited in location and scope, and it is not possible to remove moisture, especially in the bathroom and toilet environment in use. In addition, chlorine fungicides, organic mercury compounds, organophosphorus compounds, pentachlorophenol (PCP), formalin, etc., which are used as a fungicide, have excellent effects on the removal of fungi, but they can be used for respiratory and skin irritation to humans or animals. In addition to being highly toxic, some components are known as carcinogens and are regulated for use as environmental pollutants that cause environmental toxicity.

In addition, Japanese Patent Laid-Open No. 62-4202 has attempted to remove mold using 2- (4-thiazolyl) -benzimidazole, benzalkonium chloride and polyvinyl butylal. Patent Publication No. 60-54301 attempted to remove and prevent mold using diiomethylmethyl p-tolypsulfone and 2,4,5,6-terachloroisobutyronitrile. In US Patent Publication No. 480662, an attempt was made to remove mold based on 3-iodine-2-propynyl butyl carbamate. In Korean Patent Application No. 94-15806, 2- (4-thiazolyl) -benzimi Attempts were made to remove and prevent the fungus using dazole and iodine methyl p-tolylsulfone, but did not achieve good effects.

[Technical problem to be achieved]

Accordingly, the inventors have found that the above-described prior art has not been able to effectively remove all of a large number of molds by applying them to open spaces, and that the mold removal and reoccurrence prevention effects have been weakened by the appearance of molds resistant to each component. Based on the findings, research has shown that non-woven fabrics or pulp contain 3-iodo-2-propynyl butyl carbamate and 2- (4-thiazolyl) -benzimidazole as fungicidal and growth inhibitory components. It was found that the wet tissue composition has high stability and safety for the human body, shows excellent sterilization effect against molds resident in the bathroom and bathroom, and also shows excellent antiseptic and reoccurrence effect of the mold due to the synergy effect of the components. .

[Configuration and Function of Invention]

The present invention relates to the inclusion of 3-iodo-2-propynyl butyl carbamate of formula (I) and 2- (4-thiazolyl) -benzimidazole of formula (II) below and ethanol in a nonwoven fabric or pulp. It provides a wet tissue composition characterized in.

In addition, the present invention provides a method for removing a mold, characterized in that the wet tissue containing the above-described mold removing / sterilizing agent composition is applied to a place where a mold is generated.

In the wet tissue composition of the present invention, 3-iodo-2-propynyl butyl carbamate and 2- (4-thiazolyl) -benzimidazole may each contain 0.0001 to 4% by weight relative to the total weight of the composition. If the content of each of these components is used at 0.0001% by weight or less, the desired effect can not be expected, and when used in excess of 4% by weight, synergistic effects of mold removal and prevention of reoccurrence cannot be expected, uneconomical and phase instability. May have side effects on the body.

Ethanol in the wet tissue composition of the present invention may contain 10.0 to 30% by weight based on the total weight of the composition. Disinfectant disinfectant is difficult when ethanol is used in an amount less than 10.0% by weight, and it is uneconomical when used in excess of 30% by weight.

In the wet tissue composition of the present invention, the nonwoven fabric or pulp may contain 15.0 to 35.0% by weight relative to the total weight of the composition. If the nonwoven fabric or pulp content is less than 15.0% by weight, the content of the wet tissue solution is too high and economical. If the content of the non-woven fabric or pulp is more than 35.0% by weight, the content of the wet tissue solution is too low, so that the sterilization and disinfection effect is reduced.

The mechanism of action on the fungicidal sterilization and reoccurrence-preventing effects of the mold removal raw materials used in the wet tissue composition of the present invention is 3-iodo-2-propynyl butyl carbamate, which modifies the cell wall of the fungus, thereby reducing the protein synthesis pathway. 2- (4-thiazolyl) -benzimidazole acts primarily on the nucleus of the fungus to inhibit or stop cell division.

In the present invention, aspergillus niger (Aspergillus niger ATCC9642) (name: Ag), Penicillum citrinum ATCC9849 (name: Pc), Cladosporium resine ATCC52833 (Cp), Trichoderma viride ATCC32098 (abbreviated Td), Fusarium roseum ATCC13379 (abbreviated Fs), and Alternaria altertana ATCC13963. Candida albicans ATCC10231 (Cd) and Saccharomyces cerevisiae ATCC7752 (Sm) were tested for yeast.

According to the present invention, the mold removal and disinfectant composition is contained in a fabric composed of nonwoven fabric and pulp, and the mold is removed by rubbing directly on the surface of the bathroom, toilet device and other mold in which the mold is infested. It's in the form of a wet wipe.

Existing spray-type fungicides are sprayed in the place where the fungus occurs, even if the fungus dies, the fungus cells remain, and the inconvenience of having to wipe with toilet paper or other fabrics to remove the fungus, because it is sprayed into the air Inhalation into a person's respiratory system may be harmful to health. However, since the wet tissue of the present invention can be directly rubbed where the mold is generated, the fungicide effect and the cell removal are made at the same time, and thus the convenience is excellent, and since the disinfectant is not sprayed into the air, it is not inhaled by the human respirator and thus is safe for the human body.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the technical scope of the present invention is not limited to these Examples.

[Examples 1 to 15]

Dissolve the 3-iodo-2-propynyl butyl carbamate, 2- (4-thiazolyl) -benzimidazole as a fungicidal component in ethanol at 25 to 30 ℃ according to the composition ratio shown in Table 1 After the addition, it was mixed and dispersed with water with a surfactant, lauryl ethylene-7- (LA-7), to prepare a wet tissue solution. Thereafter, this wet tissue solution was immersed in a table of a certain size by weight ratio and packaged in a polypropylene container to prevent natural evaporation of the stock solution to prepare a mold removal / sterilization product.

Table 1 Example Composition Table

[Comparative Examples 1 to 15]

In Table 2, Comparative Examples 1 to 6 are diiodo methyl P-tolyl sulfone and 2,4,5,6-tetrachloro isobutyronitrile, and Comparative Examples 7 to 9 are 3-iodo-2-propynyl butyl. Carbamate and diiodo methyl P-tolyl sulfone, Comparative Examples 10-12 are 2- (4-thiazolyl) -benzimidazole and diiodo methyl P-tolyl sulfone, and Comparative Examples 13-15 are 3-iodo 2-propynyl butyl carbamate and 2,4,5,6-tetrachloro isobutyronitrile were dissolved in ethanol at 25 to 30 ° C. according to the compositional ratios described, followed by mixing and dispersing with lauryl ethylene-7 and wet wipes. Stock solutions were prepared.

Thereafter, a fungicide disinfectant product was prepared in the same manner as in Examples 1 to 15.

Table 2 Comparative Example Composition Table

Mold, yeast removal and mold growth inhibition of the wet tissue composition of the Examples and Comparative Examples were evaluated as follows.

[Evaluation of Mold, Yeast and Bacteria Removal and Disinfection]

Aspergillus niger ATCC9642 (abbreviated as Ag), Penicillum citrinum ATCC9849 (abbreviated as Pc), Cladosporium resine ATCC52833 (abbreviated as Cp), trichoderma vir Fungi and Candida albicans ATCC10231 (Trichoderma viride ATCC32098) (abbreviated as Td), Fusarium roseum ATCC13379 (abbreviated as Fs) and Alternaria altertana ATCC13963 (Candida albicans ATCC10231) Abbreviated name: Cd) and Saccharomyces cerevisiae ATCC7752 (Sm) are tested for yeasts according to the following test method and the results are shown in Tables 3 and 4. At this time, determination is based on the following criteria.

[Test Methods]

Spores or fungal suspensions of each fungus and yeast (10 ⁵ spores / ml) and suspensions of each bacterium (10 ⁶ cells / ml) are prepared and inoculated on a solid medium to which the Paper Disc Diffusion Method is to be applied. 10 μl of the mold removing and disinfectant stock solutions prepared in Examples and Comparative Examples were added to a paper disc on a solid medium, followed by incubation of molds and yeasts at 25 to 30 ° C. for 3 to 5 days. Measure the size of proliferative low ring for.

Decision 4: The size of a proliferation resistant ring is 6.0 cm <2> or more.

3: The size of proliferation resistant ring is 4.0-5.0 cm <2> or more.

2: The growth proliferation ring size is 1.0-3.99 cm <2> or more.

1: The size of a proliferation resistant ring is less than 1.0 cm <2>.

0: There is no growth inhibiting ring, or the growth phenomenon appears on the paper disk.

[Evaluation of Fungal Growth Inhibition]

The test results of the six fungi mentioned above by the following test method are shown in Tables 3 and 4. The determination is based on the following criteria.

[Test Methods]

The filter paper was soaked in a mold spore suspension (10 ⁵ spores / ml) suspended in a liquid medium, and the wet wipes for removing the fungicides described in Examples and Comparative Examples were cut into 3 × 3 cm 2 and attached to the filter paper for 5 minutes. Then remove it. The filter paper was placed in a constant temperature and humidity chamber maintained at a temperature of 28 ° C. and a relative humidity of 95% or more and incubated for 4 weeks. Every 7 days, the growth state of the fungus was observed.

Judgment 4: Fungal growth cannot be observed in the wet tissues.

3: The growth of mold is observed on the area where wet tissue is attached, but less than one third of the total area.

2: The growth of mold was observed on the wet tissue area, but less than 1/2 of the total area.

1: The growth of mold is observed on the part where wet tissue is attached, but it is less than 2/3 of the total area.

0: Fungal growth phenomenon occurs, mycelia are formed in the whole filter paper.

[Site application evaluation]

To perform the test method below, the results are shown in Tables 3 and 4 by the following criteria.

Choose a bathroom or toilet in your home where mold is common. The mold pin part is rubbed with a wet tissue prepared in Examples and Comparative Examples for 10 seconds to remove the mold and left to dry.

Afterwards, it is evaluated by observing the reoccurrence of the fungus over time.

Judgment: 4: No mold appearance until 28 days later.

3: No mold appearance within 28 days after 14 days.

2: No mold appearance within 14 days after 7 days.

1: No mold appearance within 7 days after 3 days.

0: Mold appears within 3 days.

Table 3 Example Evaluation Results

Table 4 Evaluation Example

From the results of Tables 3 and 4, the composition of the embodiment of the fungicide removal and disinfectant product according to the present invention, compared to the composition of the comparative example, excellent effect by the addition of a small amount in the removal power evaluation, growth inhibition evaluation and field application evaluation for fungi, yeasts Could get

The fungicide removal and disinfectant product according to the present invention is 3-iodo-2-propynyl butyl carbamate, 2- (4-thiazolyl) -benzimidazole in order to achieve synergy to maximize the fungicide removal effect and the prevention of reoccurrence. And ethanol were mixed and prepared. Specifically, the dosage for the effect of mold removal or the prevention of reoccurrence in the case of using a certain amount or more of 3-iodo-2-propynyl butyl carbamate and 2- (4-thiazolyl) -benzimidazole in a content ratio, respectively. A synergistic effect cannot be expected proportionally, and phase instability and toxicity to the human body may occur. In addition, even when using each of the above materials at the same time or less than the appropriate content can not be expected to have an excellent effect.

The fungicide removal and disinfectant composition according to the present invention is a fungus when the content of 3-iodo-2-propynyl butyl carbamate and 2- (4-thiazolyl) -benzimidazole is 0.0001 to 4.0% by weight of the total weight of the contents, respectively. · The results of evaluation of yeast removal and sterilization, fungal growth inhibition and field application were excellent. If the content of each of these components is less than the respective lower limit, the desired effect can not be expected, and if the upper limit is exceeded, the proportional synergistic effect of mold removal and reoccurrence prevention cannot be expected and it is uneconomical.

Claims (5)

3-iodo-2-propynyl butyl carbamate of formula (I) and 2- (4-thiazolyl) -benzimidazole of formula (II) and ethanol in a nonwoven fabric or pulp Wipes composition. The wet tissue composition according to claim 1, wherein the content of 3-iodo-2-propynyl butyl carbamate or 2- (4-thiazolyl) -benzimidazole is 0.0001 to 4.0% by weight of the total weight of the composition, respectively. . The wet tissue composition of claim 1, wherein the content of ethanol is 10.0 to 30.0 wt% of the total weight of the composition. The wet tissue composition of claim 1, wherein the wet tissue composition is 15 to 35.0% by weight of the total weight of the nonwoven fabric or pulp. A method for continuously inhibiting the growth and reoccurrence of mold, characterized by applying the wet tissue composition defined in any one of claims 1 to 4 to a habitat of the fungus.