KR102941068B1 - 질환을 치료하기 위한 류신, 아세틸 류신, 및 관련된 유사체 - Google Patents

질환을 치료하기 위한 류신, 아세틸 류신, 및 관련된 유사체

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Publication number
KR102941068B1
KR102941068B1 KR1020217031422A KR20217031422A KR102941068B1 KR 102941068 B1 KR102941068 B1 KR 102941068B1 KR 1020217031422 A KR1020217031422 A KR 1020217031422A KR 20217031422 A KR20217031422 A KR 20217031422A KR 102941068 B1 KR102941068 B1 KR 102941068B1
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KR
South Korea
Prior art keywords
disease
disorder
syndrome
leucine
subject
Prior art date
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Active
Application number
KR1020217031422A
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English (en)
Korean (ko)
Other versions
KR20210135272A (ko
Inventor
말로리 팩터
테일러 필드
Original Assignee
인트라바이오 리미티드
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Priority to KR1020257040124A priority Critical patent/KR20250171484A/ko
Publication of KR20210135272A publication Critical patent/KR20210135272A/ko
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Publication of KR102941068B1 publication Critical patent/KR102941068B1/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020217031422A 2019-03-02 2020-03-02 질환을 치료하기 위한 류신, 아세틸 류신, 및 관련된 유사체 Active KR102941068B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257040124A KR20250171484A (ko) 2019-03-02 2020-03-02 질환을 치료하기 위한 류신, 아세틸 류신, 및 관련된 유사체

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962812987P 2019-03-02 2019-03-02
US62/812,987 2019-03-02
US201962842296P 2019-05-02 2019-05-02
US62/842,296 2019-05-02
US201962888894P 2019-08-19 2019-08-19
US62/888,894 2019-08-19
US201962895144P 2019-09-03 2019-09-03
US62/895,144 2019-09-03
PCT/IB2020/051767 WO2020178721A1 (en) 2019-03-02 2020-03-02 Leucine, acetyl leucine, and related analogs for treating disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257040124A Division KR20250171484A (ko) 2019-03-02 2020-03-02 질환을 치료하기 위한 류신, 아세틸 류신, 및 관련된 유사체

Publications (2)

Publication Number Publication Date
KR20210135272A KR20210135272A (ko) 2021-11-12
KR102941068B1 true KR102941068B1 (ko) 2026-03-18

Family

ID=69845470

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020217031422A Active KR102941068B1 (ko) 2019-03-02 2020-03-02 질환을 치료하기 위한 류신, 아세틸 류신, 및 관련된 유사체
KR1020257040124A Pending KR20250171484A (ko) 2019-03-02 2020-03-02 질환을 치료하기 위한 류신, 아세틸 류신, 및 관련된 유사체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020257040124A Pending KR20250171484A (ko) 2019-03-02 2020-03-02 질환을 치료하기 위한 류신, 아세틸 류신, 및 관련된 유사체

Country Status (25)

Country Link
US (1) US20220142959A1 (https=)
EP (2) EP4464378A3 (https=)
JP (2) JP7555346B2 (https=)
KR (2) KR102941068B1 (https=)
CN (2) CN119097618A (https=)
AU (2) AU2020231189B2 (https=)
BR (1) BR112021017203A2 (https=)
CA (1) CA3131948A1 (https=)
DK (1) DK3934637T3 (https=)
ES (1) ES2990183T3 (https=)
FI (1) FI3934637T3 (https=)
HR (1) HRP20241150T1 (https=)
HU (1) HUE068527T2 (https=)
IL (2) IL285870B2 (https=)
LT (1) LT3934637T (https=)
MA (1) MA55199B1 (https=)
MD (1) MD3934637T2 (https=)
MX (2) MX2021010568A (https=)
PL (1) PL3934637T3 (https=)
PT (1) PT3934637T (https=)
RS (1) RS65849B1 (https=)
SG (1) SG11202109512SA (https=)
SI (1) SI3934637T1 (https=)
SM (1) SMT202400334T1 (https=)
WO (1) WO2020178721A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201709459D0 (en) 2017-06-14 2017-07-26 Intrabio Ltd Treatment for migraine
JP7471298B2 (ja) * 2018-12-06 2024-04-19 イントラビオ エルティーディー アセチル－ロイシンの重水素化類似体
US20250025442A1 (en) * 2020-12-10 2025-01-23 Texas Tech University System BCAA-Lowering Compounds for Prevention and/or Treatment of Alzheimer's Disease and Related Disorders
WO2022264037A1 (en) * 2021-06-14 2022-12-22 Intrabio Ltd. Branched-chain amino acid derivatives to treat disease
WO2024243004A2 (en) * 2023-05-19 2024-11-28 The Children's Hospital Of Philadelphia Compositions and methods for treating traumatic brain injury
WO2025166100A1 (en) * 2024-02-02 2025-08-07 SynGAP Research Fund Compositions and methods for treating neurodevelopmental disorders
WO2025175092A1 (en) * 2024-02-14 2025-08-21 Intrabio Inc. Acetyl leucine for treating syngap1-related disorders
WO2025264957A2 (en) * 2024-06-20 2025-12-26 Intrabio Inc. Acetyl leucine for treating neurodevelopmental disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018029658A1 (en) 2016-08-11 2018-02-15 Intrabio Limited Therapeutic agents for neurodegenerative diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060063827A1 (en) * 2004-09-23 2006-03-23 Yu Ruey J Systemic administration of therapeutic amino acids and N-acetylamino acids
FR2905600B1 (fr) * 2006-09-13 2010-01-15 Pf Medicament Traitement des vertiges par l'acetyl-l-leucine.
TN2010000251A1 (fr) * 2010-06-03 2011-11-11 Rekik Raouf N-acetyl-dl-leucine medicament neuro et retino protecteur
SMT201600385T1 (it) 2010-06-25 2017-03-08 Shire Human Genetic Therapies Trasporto di agenti terapeutici all’snc
US20140080885A1 (en) * 2012-09-13 2014-03-20 University Of South Florida (A Florida Non-Profit Corporation) Methods of treating traumatic brain injury
US10905670B2 (en) * 2016-04-19 2021-02-02 Intrabio Ltd. Acetyl-leucine or a pharmaceutically acceptable salt thereof for improved mobility and cognitive function
TN2016000259A1 (en) * 2016-06-27 2017-10-06 Rekik Raouf Salbutamol (albuterol) eye protective medicament.
NZ750391A (en) 2016-08-11 2026-03-27 Intrabio Ltd Pharmaceutical compositions and uses directed to lysosomal storage disorders
WO2019036442A1 (en) 2017-08-14 2019-02-21 Axcella Health Inc. AMINO ACIDS BRANCHED FOR THE TREATMENT OF NEURONAL INJURY

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018029658A1 (en) 2016-08-11 2018-02-15 Intrabio Limited Therapeutic agents for neurodegenerative diseases

Also Published As

Publication number Publication date
SG11202109512SA (en) 2021-09-29
ES2990183T3 (es) 2024-11-29
CN114040757A (zh) 2022-02-11
IL285870B2 (en) 2025-12-01
MA55199A (fr) 2022-01-12
SMT202400334T1 (it) 2024-09-16
IL321899A (en) 2025-09-01
CA3131948A1 (en) 2020-09-10
US20220142959A1 (en) 2022-05-12
IL285870B1 (en) 2025-08-01
EP3934637A1 (en) 2022-01-12
RS65849B1 (sr) 2024-09-30
LT3934637T (lt) 2024-08-26
BR112021017203A2 (pt) 2021-12-14
JP2024170602A (ja) 2024-12-10
EP4464378A3 (en) 2025-04-09
MD3934637T2 (ro) 2024-12-31
JP2022522819A (ja) 2022-04-20
AU2020231189A1 (en) 2021-09-30
MX2024015063A (es) 2025-01-09
EP3934637B1 (en) 2024-07-31
PT3934637T (pt) 2024-08-30
JP7555346B2 (ja) 2024-09-24
MX2021010568A (es) 2021-11-12
HRP20241150T1 (hr) 2024-11-22
AU2025204995A1 (en) 2025-07-17
WO2020178721A1 (en) 2020-09-10
PL3934637T3 (pl) 2024-10-14
AU2020231189B2 (en) 2025-07-24
FI3934637T3 (fi) 2024-09-02
DK3934637T3 (da) 2024-09-02
CN119097618A (zh) 2024-12-10
KR20250171484A (ko) 2025-12-08
SI3934637T1 (sl) 2024-10-30
IL285870A (en) 2021-10-31
CN114040757B (zh) 2024-09-20
KR20210135272A (ko) 2021-11-12
MA55199B1 (fr) 2024-08-30
HUE068527T2 (hu) 2025-01-28
EP4464378A2 (en) 2024-11-20

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