KR102934104B1 - G12r 돌연변이를 갖는 ras에 대한 hla 클래스 ii-제한된 t 세포 수용체 - Google Patents

G12r 돌연변이를 갖는 ras에 대한 hla 클래스 ii-제한된 t 세포 수용체

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KR102934104B1
KR102934104B1 KR1020217026169A KR20217026169A KR102934104B1 KR 102934104 B1 KR102934104 B1 KR 102934104B1 KR 1020217026169 A KR1020217026169 A KR 1020217026169A KR 20217026169 A KR20217026169 A KR 20217026169A KR 102934104 B1 KR102934104 B1 KR 102934104B1
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amino acid
acid sequence
seq
leu
ser
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KR20210118865A (ko
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라미 요셉
마리아 알 파쿠르스트
안나 파세토
스티븐 에이 로젠버그
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더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈
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KR1020217026169A 2019-01-22 2020-01-21 G12r 돌연변이를 갖는 ras에 대한 hla 클래스 ii-제한된 t 세포 수용체 Active KR102934104B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962795203P 2019-01-22 2019-01-22
US62/795,203 2019-01-22
PCT/US2020/014382 WO2020154275A1 (en) 2019-01-22 2020-01-21 Hla class ii-restricted t cell receptors against ras with g12r mutation

Publications (2)

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KR20210118865A KR20210118865A (ko) 2021-10-01
KR102934104B1 true KR102934104B1 (ko) 2026-03-06

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US (2) US12448428B2 (https=)
EP (1) EP3914612A1 (https=)
JP (2) JP7672979B2 (https=)
KR (1) KR102934104B1 (https=)
CN (2) CN113412277B (https=)
AU (1) AU2020211922B2 (https=)
CA (1) CA3127096A1 (https=)
WO (1) WO2020154275A1 (https=)

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Publication number Priority date Publication date Assignee Title
IL305393A (en) 2021-02-25 2023-10-01 Alaunos Therapeutics Inc Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof
US20250145950A1 (en) 2022-02-01 2025-05-08 Alaunos Therapeutics, Inc. Methods for Activation and Expansion of T Cells
WO2025006196A1 (en) 2023-06-28 2025-01-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors targeting ras with g12d, g12r, or g12v mutation
CN119119290B (zh) * 2024-07-15 2025-11-25 上海交通大学医学院附属瑞金医院 靶向flt3 d835h突变衍生新抗原的tcr及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003265948B8 (en) 2002-09-06 2009-09-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
WO2012129201A1 (en) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
ES2834070T3 (es) 2011-09-15 2021-06-16 Us Health Receptores de células T que reconocen MAGE restringido por HLA-A1 o HLA-Cw7
WO2015123532A1 (en) * 2014-02-16 2015-08-20 Globeimmune, Inc. Ras g12r immunotherapy for ras mutation-positive cancers
MX384919B (es) * 2014-11-26 2025-03-14 Us Health Receptores de células t de kras anti-mutado.
RU2018101225A (ru) 2015-06-16 2019-07-16 Тарговакс Аса Мутированные фрагменты белка ras
JP7185524B2 (ja) * 2015-09-15 2022-12-07 アメリカ合衆国 Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体
DE102016115246C5 (de) * 2016-08-17 2018-12-20 Immatics Biotechnologies Gmbh Neue t-zellrezeptoren und deren verwendung in immuntherapie
CN108264550B (zh) * 2017-01-04 2021-04-23 香雪生命科学技术（广东）有限公司 一种识别源自于prame抗原短肽的tcr
CN108395479B (zh) * 2017-02-06 2021-07-16 高军 一种有关kras基因突变的t细胞受体
WO2025006196A1 (en) 2023-06-28 2025-01-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors targeting ras with g12d, g12r, or g12v mutation

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Publication number Publication date
WO2020154275A1 (en) 2020-07-30
US12448428B2 (en) 2025-10-21
KR20210118865A (ko) 2021-10-01
JP2025114614A (ja) 2025-08-05
US20220089673A1 (en) 2022-03-24
CN113412277A (zh) 2021-09-17
EP3914612A1 (en) 2021-12-01
AU2020211922B2 (en) 2025-05-29
CN113412277B (zh) 2025-07-18
TW202043262A (zh) 2020-12-01
JP2022523024A (ja) 2022-04-21
JP7672979B2 (ja) 2025-05-08
US20260008832A1 (en) 2026-01-08
AU2020211922A1 (en) 2021-08-12
CA3127096A1 (en) 2020-07-30
CN120607607A (zh) 2025-09-09

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