KR102930070B1 - 범-대립유전자 모델을 갖는 신생항원 동정 - Google Patents

범-대립유전자 모델을 갖는 신생항원 동정

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Publication number
KR102930070B1
KR102930070B1 KR1020207027458A KR20207027458A KR102930070B1 KR 102930070 B1 KR102930070 B1 KR 102930070B1 KR 1020207027458 A KR1020207027458 A KR 1020207027458A KR 20207027458 A KR20207027458 A KR 20207027458A KR 102930070 B1 KR102930070 B1 KR 102930070B1
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mhc
allele
peptide
presentation
model
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KR20200127001A (ko
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토마스 프란시스 바우처
브렌던 불릭-술리반
제니퍼 버스비
모카 스코베르네
로만 엘렌스키
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시애틀 프로젝트 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/20—Sequence assembly
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539—MHC-molecules, e.g. HLA-molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Data Mining & Analysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Software Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
KR1020207027458A 2018-02-27 2019-02-27 범-대립유전자 모델을 갖는 신생항원 동정 Active KR102930070B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020267004996A KR20260041858A (ko) 2018-02-27 2019-02-27 범-대립유전자 모델을 갖는 신생항원 동정

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862636061P 2018-02-27 2018-02-27
US62/636,061 2018-02-27
PCT/US2019/019836 WO2019168984A1 (en) 2018-02-27 2019-02-27 Neoantigen identification with pan-allele models

Related Child Applications (1)

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KR1020267004996A Division KR20260041858A (ko) 2018-02-27 2019-02-27 범-대립유전자 모델을 갖는 신생항원 동정

Publications (2)

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KR20200127001A KR20200127001A (ko) 2020-11-09
KR102930070B1 true KR102930070B1 (ko) 2026-02-24

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KR1020267004996A Pending KR20260041858A (ko) 2018-02-27 2019-02-27 범-대립유전자 모델을 갖는 신생항원 동정

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Country Status (10)

Country Link
US (1) US20200411135A1 (https=)
EP (1) EP3759131A4 (https=)
JP (1) JP7480064B2 (https=)
KR (2) KR102930070B1 (https=)
CN (2) CN119851752A (https=)
AU (2) AU2019227813B2 (https=)
CA (1) CA3091917A1 (https=)
IL (1) IL276839A (https=)
TW (1) TW202000693A (https=)
WO (1) WO2019168984A1 (https=)

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WO2022121973A1 (zh) * 2020-12-09 2022-06-16 江苏恒瑞医药股份有限公司 基于机器学习的肽免疫原性预测、鉴别系统及方法
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KR102769935B1 (ko) * 2021-03-30 2025-02-19 한국과학기술원 펩타이드-mhc에 대한 t 세포 활성의 예측 방법 및 분석장치
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Also Published As

Publication number Publication date
US20200411135A1 (en) 2020-12-31
CN111868080B (zh) 2024-11-29
AU2024220070A1 (en) 2024-10-17
CN111868080A (zh) 2020-10-30
IL276839A (en) 2020-10-29
JP2021514671A (ja) 2021-06-17
WO2019168984A1 (en) 2019-09-06
CN119851752A (zh) 2025-04-18
AU2019227813B2 (en) 2024-06-27
KR20200127001A (ko) 2020-11-09
JP7480064B2 (ja) 2024-05-09
AU2019227813A1 (en) 2020-10-01
TW202000693A (zh) 2020-01-01
CA3091917A1 (en) 2019-09-06
WO2019168984A8 (en) 2020-06-04
EP3759131A1 (en) 2021-01-06
KR20260041858A (ko) 2026-03-27
EP3759131A4 (en) 2021-12-01

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