KR102874431B1 - 생물 반응기 또는 발효기 시스템에서의 사용을 위한 혼합 어셈블리 - Google Patents

생물 반응기 또는 발효기 시스템에서의 사용을 위한 혼합 어셈블리

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Publication number
KR102874431B1
KR102874431B1 KR1020247008550A KR20247008550A KR102874431B1 KR 102874431 B1 KR102874431 B1 KR 102874431B1 KR 1020247008550 A KR1020247008550 A KR 1020247008550A KR 20247008550 A KR20247008550 A KR 20247008550A KR 102874431 B1 KR102874431 B1 KR 102874431B1
Authority
KR
South Korea
Prior art keywords
drive line
drive
assembly
container
drive lines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020247008550A
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English (en)
Korean (ko)
Other versions
KR20240042115A (ko
Inventor
네피 디. 존스
크리스토퍼 디. 브라우
Original Assignee
라이프 테크놀로지스 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of KR20240042115A publication Critical patent/KR20240042115A/ko
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Publication of KR102874431B1 publication Critical patent/KR102874431B1/ko
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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02Stirrer or mobile mixing elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05Stirrers
    • B01F27/051Stirrers characterised by their elements, materials or mechanical properties
    • B01F27/054Deformable stirrers, e.g. deformed by a centrifugal force applied during operation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05Stirrers
    • B01F27/11Stirrers characterised by the configuration of the stirrers
    • B01F27/111Centrifugal stirrers, i.e. stirrers with radial outlets; Stirrers of the turbine type, e.g. with means to guide the flow
    • B01F27/1111Centrifugal stirrers, i.e. stirrers with radial outlets; Stirrers of the turbine type, e.g. with means to guide the flow with a flat disc or with a disc-like element equipped with blades, e.g. Rushton turbine
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05Stirrers
    • B01F27/11Stirrers characterised by the configuration of the stirrers
    • B01F27/115Stirrers characterised by the configuration of the stirrers comprising discs or disc-like elements essentially perpendicular to the stirrer shaft axis
    • B01F27/1152Stirrers characterised by the configuration of the stirrers comprising discs or disc-like elements essentially perpendicular to the stirrer shaft axis with separate elements other than discs fixed on the discs, e.g. vanes fixed on the discs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05Stirrers
    • B01F27/11Stirrers characterised by the configuration of the stirrers
    • B01F27/119Stirrers with rigid wires or flexible rods
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05Stirrers
    • B01F27/11Stirrers characterised by the configuration of the stirrers
    • B01F27/19Stirrers with two or more mixing elements mounted in sequence on the same axis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05Stirrers
    • B01F27/11Stirrers characterised by the configuration of the stirrers
    • B01F27/19Stirrers with two or more mixing elements mounted in sequence on the same axis
    • B01F27/191Stirrers with two or more mixing elements mounted in sequence on the same axis with similar elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/21Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by their rotating shafts
    • B01F27/211Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by their rotating shafts characterised by the material of the shaft
    • B01F27/2111Flexible shafts
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/90Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms 
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/40Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
    • B01F35/41Mounting or supporting stirrer shafts or stirrer units on receptacles
    • B01F35/412Mounting or supporting stirrer shafts or stirrer units on receptacles by supporting both extremities of the shaft
    • B01F35/4121Mounting or supporting stirrer shafts or stirrer units on receptacles by supporting both extremities of the shaft at the top and at the bottom of the receptacle, e.g. for performing a conical orbital movement about a vertical axis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50Mixing receptacles
    • B01F35/513Flexible receptacles, e.g. bags supported by rigid containers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • C12M1/007Flexible bags or containers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • C12M1/02Apparatus for enzymology or microbiology with agitation means; with heat exchange means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/14Bags
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/26Constructional details, e.g. recesses, hinges flexible
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/44Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Accessories For Mixers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
KR1020247008550A 2015-12-29 2016-12-21 생물 반응기 또는 발효기 시스템에서의 사용을 위한 혼합 어셈블리 Active KR102874431B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562272504P 2015-12-29 2015-12-29
US62/272,504 2015-12-29
PCT/US2016/068064 WO2017116909A1 (en) 2015-12-29 2016-12-21 Fluid mixing system with laterally displaced flexible drive lines and methods of use
KR1020187022059A KR102649446B1 (ko) 2015-12-29 2016-12-21 측면으로 변위되는 가요성 드라이브 라인들을 갖는 유체 혼합 시스템 및 사용 방법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187022059A Division KR102649446B1 (ko) 2015-12-29 2016-12-21 측면으로 변위되는 가요성 드라이브 라인들을 갖는 유체 혼합 시스템 및 사용 방법

Publications (2)

Publication Number Publication Date
KR20240042115A KR20240042115A (ko) 2024-04-01
KR102874431B1 true KR102874431B1 (ko) 2025-10-21

Family

ID=57797013

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020247008550A Active KR102874431B1 (ko) 2015-12-29 2016-12-21 생물 반응기 또는 발효기 시스템에서의 사용을 위한 혼합 어셈블리
KR1020187022059A Active KR102649446B1 (ko) 2015-12-29 2016-12-21 측면으로 변위되는 가요성 드라이브 라인들을 갖는 유체 혼합 시스템 및 사용 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020187022059A Active KR102649446B1 (ko) 2015-12-29 2016-12-21 측면으로 변위되는 가요성 드라이브 라인들을 갖는 유체 혼합 시스템 및 사용 방법

Country Status (8)

Country Link
US (3) US10669515B2 (https=)
EP (2) EP3397377B1 (https=)
JP (3) JP7078535B2 (https=)
KR (2) KR102874431B1 (https=)
CN (2) CN113975988B (https=)
BR (1) BR112018013173B1 (https=)
DK (1) DK3397377T3 (https=)
WO (1) WO2017116909A1 (https=)

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CN113975988B (zh) 2015-12-29 2024-09-03 生命科技股份有限公司 具有侧向移位的柔性驱动线的流体混合系统及使用方法
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CN111699240A (zh) * 2018-01-17 2020-09-22 生命技术公司 用于细胞培养缩放的系统和方法
CN109652300A (zh) * 2018-11-15 2019-04-19 上海量能生物科技有限公司 生物反应器
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CN115920684B (zh) * 2023-03-14 2023-05-12 山东百农思达生物科技有限公司 农药配比装置
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