KR102747514B1 - 미세유체 입자 분리 향상 방법 및 이의 장치 - Google Patents

미세유체 입자 분리 향상 방법 및 이의 장치 Download PDF

Info

Publication number
KR102747514B1
KR102747514B1 KR1020217019572A KR20217019572A KR102747514B1 KR 102747514 B1 KR102747514 B1 KR 102747514B1 KR 1020217019572 A KR1020217019572 A KR 1020217019572A KR 20217019572 A KR20217019572 A KR 20217019572A KR 102747514 B1 KR102747514 B1 KR 102747514B1
Authority
KR
South Korea
Prior art keywords
hydrofoil
particles
cambered
main axis
downstream
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020217019572A
Other languages
English (en)
Korean (ko)
Other versions
KR20210110307A (ko
Inventor
구르한 오즈카야르
엔더 일드름
오즈게 졸루
Original Assignee
마이크로 바이오시스템러 일렉트로닉 사나이 베 티자레트 에이.에스.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 마이크로 바이오시스템러 일렉트로닉 사나이 베 티자레트 에이.에스. filed Critical 마이크로 바이오시스템러 일렉트로닉 사나이 베 티자레트 에이.에스.
Publication of KR20210110307A publication Critical patent/KR20210110307A/ko
Application granted granted Critical
Publication of KR102747514B1 publication Critical patent/KR102747514B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1028—Sorting particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
KR1020217019572A 2018-12-28 2019-05-03 미세유체 입자 분리 향상 방법 및 이의 장치 Active KR102747514B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
TRPCT/TR2018/050932 2018-12-28
PCT/TR2018/050932 WO2020139210A1 (en) 2018-12-28 2018-12-28 A method of microfluidic particle separation enhancement and the device thereof
PCT/TR2019/050295 WO2020139218A1 (en) 2018-12-28 2019-05-03 A method of microfluidic particle separation enhancement and the device thereof

Publications (2)

Publication Number Publication Date
KR20210110307A KR20210110307A (ko) 2021-09-07
KR102747514B1 true KR102747514B1 (ko) 2024-12-31

Family

ID=71128840

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217019572A Active KR102747514B1 (ko) 2018-12-28 2019-05-03 미세유체 입자 분리 향상 방법 및 이의 장치

Country Status (8)

Country Link
US (1) US12036553B2 (enExample)
EP (1) EP3873669A4 (enExample)
JP (1) JP7418026B2 (enExample)
KR (1) KR102747514B1 (enExample)
AU (1) AU2019414140B2 (enExample)
IL (1) IL284275B2 (enExample)
SG (1) SG11202106718QA (enExample)
WO (2) WO2020139210A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102474060B1 (ko) * 2020-10-14 2022-12-05 한국과학기술연구원 미세유체칩 유동에 의한 세포입자의 크기별 분리 장치와 방법
EP4265336A1 (en) * 2020-12-21 2023-10-25 IHI Corporation Solid-liquid separation device and solid-liquid separation system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001527220A (ja) 1997-12-24 2001-12-25 シーフィード 一体型流体操作カートリッジ
JP2008137003A (ja) 2006-11-30 2008-06-19 Palo Alto Research Center Inc 流体内の粒子を処理する装置及びらせん形分離装置を形成する方法
JP2009530400A (ja) 2006-03-23 2009-08-27 ヴェロシス，インク． マイクロチャネルプロセス技術を用いてスチレンを作るためのプロセス
WO2009129586A1 (en) 2008-04-24 2009-10-29 Filtra Limited Centrifugal separator
JP2016537198A (ja) 2013-10-25 2016-12-01 トラァイロバイト イノヴェイション アクティーゼルスカブ 流体濾過装置及びアセンブリー

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1585583B1 (en) * 2002-10-23 2010-04-07 The Trustees of Princeton University Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields
US20070059719A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Business methods for prenatal Diagnosis
EP2321055A4 (en) * 2008-07-10 2012-01-18 Steven H Reichenbach METHOD AND DEVICE FOR SORTING PARTICLES USING ASYMMETRIC PARTICLE SHIFT
GB0913523D0 (en) * 2009-08-03 2009-09-16 Vestfold University College Improved cross flow and counter flow fluid processing devices
US9458489B2 (en) * 2010-03-04 2016-10-04 Massachusetts Institute Of Technology Microfluidics sorter for cell detection and isolation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001527220A (ja) 1997-12-24 2001-12-25 シーフィード 一体型流体操作カートリッジ
JP2009530400A (ja) 2006-03-23 2009-08-27 ヴェロシス，インク． マイクロチャネルプロセス技術を用いてスチレンを作るためのプロセス
JP2008137003A (ja) 2006-11-30 2008-06-19 Palo Alto Research Center Inc 流体内の粒子を処理する装置及びらせん形分離装置を形成する方法
WO2009129586A1 (en) 2008-04-24 2009-10-29 Filtra Limited Centrifugal separator
JP2016537198A (ja) 2013-10-25 2016-12-01 トラァイロバイト イノヴェイション アクティーゼルスカブ 流体濾過装置及びアセンブリー

Also Published As

Publication number Publication date
WO2020139218A1 (en) 2020-07-02
AU2019414140A1 (en) 2021-07-15
US12036553B2 (en) 2024-07-16
IL284275B1 (en) 2024-10-01
JP2022526064A (ja) 2022-05-23
KR20210110307A (ko) 2021-09-07
EP3873669A4 (en) 2021-12-29
EP3873669A1 (en) 2021-09-08
IL284275B2 (en) 2025-02-01
JP7418026B2 (ja) 2024-01-19
US20220072551A1 (en) 2022-03-10
SG11202106718QA (en) 2021-07-29
WO2020139210A1 (en) 2020-07-02
IL284275A (en) 2021-08-31
AU2019414140B2 (en) 2023-07-06

Similar Documents

Publication Publication Date Title
Al-Faqheri et al. Particle/cell separation on microfluidic platforms based on centrifugation effect: A review
US11833508B2 (en) Multi-dimensional double spiral device and methods of use thereof
Lenshof et al. Continuous separation of cells and particles in microfluidic systems
Hajba et al. Circulating tumor-cell detection and capture using microfluidic devices
Zhang et al. High throughput extraction of plasma using a secondary flow-aided inertial microfluidic device
Chung et al. Microstructure-induced helical vortices allow single-stream and long-term inertial focusing
US8807879B2 (en) Systems and methods for particle focusing in microchannels
Yousuff et al. Microfluidic platform for cell isolation and manipulation based on cell properties
Farahinia et al. Recent developments in inertial and centrifugal microfluidic systems along with the involved forces for cancer cell separation: A review
JP5641213B2 (ja) 連続的２次元粒子分離装置および粒子分離方法
Lin et al. Continuous labeling of circulating tumor cells with microbeads using a vortex micromixer for highly selective isolation
US20080067068A1 (en) DC-dielectrophoresis microfluidic apparatus, and applications of same
Shen et al. Ultra-low aspect ratio spiral microchannel with ordered micro-bars for flow-rate insensitive blood plasma extraction
Marchalot et al. Multi-step microfluidic system for blood plasma separation: Architecture and separation efficiency
Shin et al. Inertia-activated cell sorting of immune-specifically labeled cells in a microfluidic device
Fan et al. Continuous 3D particle focusing in a microchannel with curved and symmetric sharp corner structures
Fan et al. Single particle train ordering in microchannel based on inertial and vortex effects
JP7418026B2 (ja) マイクロ流体粒子分離強化の方法およびその装置
Feng et al. Size and shape based chromosome separation in the inertial focusing device
Zhao et al. Microfluidic separation of viruses from blood cells based on intrinsic transport processes
RU2782098C1 (ru) Способ улучшения разделения микрожидкостных частиц и устройство для способа
Ramachandraiah Microfluidic based isolation of circulating tumor cells from whole blood for cancer diagnostics
Ramya et al. Computational model of an inertially governed PDMS microchannel for blood cell sorting
Bhagat et al. Spiral microfluidic nanoparticle separators
Martel-Foley Inertial microfluidic cell separation

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20210624

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20220307

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20240528

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20240930

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20241223

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20241224

End annual number: 3

Start annual number: 1

PG1601 Publication of registration