KR102736868B1 - 재조합 변형된 백시니아 바이러스 앙카라 (mva) 필로바이러스 백신 - Google Patents

재조합 변형된 백시니아 바이러스 앙카라 (mva) 필로바이러스 백신 Download PDF

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KR102736868B1
KR102736868B1 KR1020177006091A KR20177006091A KR102736868B1 KR 102736868 B1 KR102736868 B1 KR 102736868B1 KR 1020177006091 A KR1020177006091 A KR 1020177006091A KR 20177006091 A KR20177006091 A KR 20177006091A KR 102736868 B1 KR102736868 B1 KR 102736868B1
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KR20170048396A (ko
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아리안 폴크만
로빈 슈타이거발트
후베르투스 호체라인
울리케 디르마이어
헤닌크 라후터바흐
유르겐 하우스만
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버베리안 노딕 에이/에스
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2760/14011—Filoviridae
    • C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
    • C12N2760/14134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14211—Marburgvirus, e.g. lake Victoria marburgvirus
    • C12N2760/14234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020177006091A 2014-09-03 2015-09-03 재조합 변형된 백시니아 바이러스 앙카라 (mva) 필로바이러스 백신 Active KR102736868B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237030452A KR102812180B1 (ko) 2014-09-03 2015-09-03 재조합 변형된 백시니아 바이러스 앙카라 (mva) 필로바이러스 백신

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462045538P 2014-09-03 2014-09-03
US62/045,538 2014-09-03
US201462055154P 2014-09-25 2014-09-25
US62/055,154 2014-09-25
PCT/EP2015/070161 WO2016034678A2 (en) 2014-09-03 2015-09-03 Recombinant modified vaccinia virus ankara (mva) filovirus vaccine

Related Child Applications (1)

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KR1020237030452A Division KR102812180B1 (ko) 2014-09-03 2015-09-03 재조합 변형된 백시니아 바이러스 앙카라 (mva) 필로바이러스 백신

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KR20170048396A KR20170048396A (ko) 2017-05-08
KR102736868B1 true KR102736868B1 (ko) 2024-12-02

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KR1020237030452A Active KR102812180B1 (ko) 2014-09-03 2015-09-03 재조합 변형된 백시니아 바이러스 앙카라 (mva) 필로바이러스 백신

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US (2) US10576141B2 (enExample)
EP (1) EP3188752A2 (enExample)
JP (2) JP6823586B2 (enExample)
KR (2) KR102736868B1 (enExample)
CN (2) CN106999565B (enExample)
AU (2) AU2015310909B2 (enExample)
CA (1) CA2959105C (enExample)
IL (2) IL250552B (enExample)
MX (1) MX2017002791A (enExample)
MY (1) MY193417A (enExample)
SG (2) SG10201901735XA (enExample)
UA (1) UA126848C2 (enExample)
WO (1) WO2016034678A2 (enExample)
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Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
JP2014527799A (ja) 2011-08-26 2014-10-23 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
WO2016071306A1 (en) 2014-11-04 2016-05-12 Crucell Holland B.V. Therapeutic hpv16 vaccines
WO2016083472A1 (en) * 2014-11-26 2016-06-02 Neuravi Limited A clot retrieval device for removing occlusive clot from a blood vessel
EP3244919A4 (en) 2015-01-12 2018-06-27 Geovax, Inc. Compositions and methods for generating an immune response to a hemorrhagic fever virus
WO2016144564A2 (en) * 2015-02-25 2016-09-15 Memorial Sloan-Kettering Cancer Center Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors
EP3283508B1 (en) 2015-04-17 2021-03-17 Alpine Immune Sciences, Inc. Immunomodulatory proteins with tunable affinities
PL3402802T3 (pl) 2016-01-08 2023-06-05 Geovax, Inc. Kompozycje i sposoby generowania odpowiedzi immunologicznej względem antygenu powiązanego z guzem nowotworowym
WO2017136419A1 (en) 2016-02-03 2017-08-10 Geovax Inc. Compositions and methods for generating an immune response to a flavivirus
WO2017143236A1 (en) 2016-02-19 2017-08-24 Yoshihiro Kawaoka Improved influenza b virus replication for vaccine development
KR102824067B1 (ko) 2016-04-15 2025-06-23 알파인 이뮨 사이언시즈, 인코포레이티드 Icos 리간드 변이체 면역조절 단백질 및 그의 용도
EP3443000B1 (en) 2016-04-15 2025-11-12 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
US10517944B2 (en) * 2016-05-02 2019-12-31 Janssen Vaccines & Prevention B.V. Therapeutic HPV vaccine combinations
WO2018011768A1 (en) * 2016-07-15 2018-01-18 Janssen Vaccines And Prevention B.V. Methods and compositions for inducing protective immunity against a marburg virus infection
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
AU2017345764A1 (en) * 2016-10-20 2019-05-02 Alpine Immune Sciences, Inc. Secretable variant immunomodulatory proteins and engineered cell therapy
CN110809581A (zh) 2017-03-16 2020-02-18 高山免疫科学股份有限公司 Pd-l2变体免疫调节蛋白及其用途
CA3054068A1 (en) 2017-03-16 2018-09-20 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
US11173204B2 (en) 2017-04-06 2021-11-16 Janssen Vaccines & Prevention B.V. MVA-BN and Ad26.ZEBOV or Ad26.filo prime-boost regimen
JP7406377B2 (ja) * 2017-05-15 2023-12-27 ヤンセン ファッシンズ アンド プリベンション ベーフェー 安定なウイルス含有組成物
US11306292B2 (en) 2017-05-15 2022-04-19 Janssen Vaccines & Prevention B.V. Stable virus-containing composition
WO2019018501A1 (en) * 2017-07-18 2019-01-24 Geovax Inc. COMPOSITIONS AND METHODS FOR GENERATING LASV IMMUNE RESPONSE
US11311612B2 (en) 2017-09-19 2022-04-26 Geovax, Inc. Compositions and methods for generating an immune response to treat or prevent malaria
GB201716181D0 (en) * 2017-10-04 2017-11-15 Univ Cape Town Recombinant mva with modified hiv-1 env
KR102813968B1 (ko) 2017-10-10 2025-05-29 알파인 이뮨 사이언시즈, 인코포레이티드 Ctla-4 변이체 면역조절 단백질 및 이의 용도
MX2020004540A (es) 2017-10-18 2020-08-03 Alpine Immune Sciences Inc Proteinas inmunomoduladoras de ligando icos variante y composiciones y metodos relacionados.
US11197926B2 (en) 2017-10-25 2021-12-14 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
EP3735417A1 (en) 2018-01-03 2020-11-11 Alpine Immune Sciences, Inc. Multi-domain immunomodulatory proteins and methods of use thereof
JP7783047B2 (ja) * 2018-08-07 2025-12-09 ウィスコンシン アルムニ リサーチ ファンデイション 組換えの生物学的に封じ込められたフィロウイルスワクチン
JP7655849B2 (ja) 2018-08-20 2025-04-02 ウィスコンシン アルムニ リサーチ ファンデイション ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
CA3111273C (en) 2018-09-06 2024-03-26 Bavarian Nordic A/S Storage improved poxvirus compositions
WO2020065349A2 (en) * 2018-09-28 2020-04-02 The Chancellor, Masters And Scholars Of The University Of Cambridge Vaccines and methods
EP3921413A1 (en) 2019-02-08 2021-12-15 Wisconsin Alumni Research Foundation (WARF) Humanized cell line
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
JP2023511444A (ja) 2020-01-24 2023-03-17 ウィスコンシン アルムニ リサーチ ファンデイション 安定化されたｎａを有する組換えインフルエンザウイルス
JP7712284B2 (ja) 2020-03-12 2025-07-23 バヴァリアン・ノルディック・アクティーゼルスカブ ポックスウイルスの安定性を改善する組成物
WO2021195410A1 (en) 2020-03-25 2021-09-30 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
CN115819616B (zh) * 2021-07-28 2025-04-11 江苏瑞科生物技术股份有限公司 一种基因重组vzv融合蛋白及其制备方法和应用
AU2024236322A1 (en) 2023-03-10 2025-08-21 Bavarian Nordic A/S Methods of isolating poxviruses from avian cell cultures
AU2024234386A1 (en) 2023-03-10 2025-08-28 Bavarian Nordic A/S Production of poxviruses from quail cell cultures
WO2024188801A1 (en) 2023-03-10 2024-09-19 Bavarian Nordic A/S Use of quail cell lines for poxvirus production

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013155441A1 (en) * 2012-04-12 2013-10-17 The Trustees Of The University Of Pennsylvania Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same
WO2014037124A1 (en) * 2012-09-04 2014-03-13 Bavarian Nordic A/S Methods and compositions for enhancing vaccine immune responses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1586331B1 (en) * 2001-10-01 2008-05-28 The Government of the U.S.A., as repr. by the Secretary, Dept. of Health & Human Services, the Nat. Inst. of Health Development of a preventive vaccine for filovirus infection in primates
CA2776522C (en) * 2001-10-01 2015-02-17 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Development of a preventive vaccine for filovirus infection in primates
WO2004042001A2 (en) * 2002-05-17 2004-05-21 Emory University Virus-like particles, methods of preparation, and immonogenic compositions
CA2581840C (en) * 2004-09-27 2014-08-05 Crucell Holland B.V. Optimized vaccines to provide protection against ebola and other viruses
GB0706912D0 (en) * 2007-04-10 2007-05-16 Isis Innovation Novel viral vaccines
EP3351628B1 (en) * 2008-10-24 2023-07-26 The Government of The United States of America as represented by The Secretary, Department of Health and Human Services Human ebola virus species and compositions and methods thereof
ES2618103T3 (es) 2008-11-21 2017-06-20 Bavarian Nordic A/S Vector que comprende múltiples secuencias de nucleótidos homólogas
WO2011071574A2 (en) * 2009-09-02 2011-06-16 United States Deparment Of The Army, As Represented By The Secretary Of The Army Monoclonal antibodies against glycoprotein of ebola sudan boniface virus
WO2011130627A2 (en) 2010-04-16 2011-10-20 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Chimpanzee adenoviral vector-based filovirus vaccines
GB201303406D0 (en) 2013-02-26 2013-04-10 Health Prot Agency Crimean-Congo Haemorrhagic Fever Virus Antigenic Composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013155441A1 (en) * 2012-04-12 2013-10-17 The Trustees Of The University Of Pennsylvania Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same
WO2014037124A1 (en) * 2012-09-04 2014-03-13 Bavarian Nordic A/S Methods and compositions for enhancing vaccine immune responses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
일본 공표특허공보 특표2005-508916호(2005.04.07.)*

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CN106999565A (zh) 2017-08-01
JP2021063112A (ja) 2021-04-22
AU2021209228A1 (en) 2021-08-19
MY193417A (en) 2022-10-12
US20200268872A1 (en) 2020-08-27
AU2015310909B2 (en) 2021-05-27
KR20230134155A (ko) 2023-09-20
JP7113924B2 (ja) 2022-08-05
JP2017527557A (ja) 2017-09-21
KR102812180B1 (ko) 2025-05-23
BR112017003908A2 (pt) 2018-02-27
KR20170048396A (ko) 2017-05-08
AU2015310909A1 (en) 2017-03-02
CA2959105A1 (en) 2016-03-10
JP6823586B2 (ja) 2021-02-03
EP3188752A2 (en) 2017-07-12
US10576141B2 (en) 2020-03-03
US11338030B2 (en) 2022-05-24
SG11201701506PA (en) 2017-03-30
IL290052A (en) 2022-03-01
IL250552B (en) 2022-02-01
WO2016034678A3 (en) 2016-06-02
IL250552A0 (en) 2017-03-30
SG10201901735XA (en) 2019-03-28
MX2017002791A (es) 2017-05-30
ZA201701077B (en) 2022-07-27
WO2016034678A2 (en) 2016-03-10
US20170304427A1 (en) 2017-10-26
CN106999565B (zh) 2021-03-05
NZ729012A (en) 2023-12-22
CA2959105C (en) 2023-10-17
CN112972668A (zh) 2021-06-18

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