KR102716931B1 - Lif에 대한 항체 및 이의 용도 - Google Patents

Lif에 대한 항체 및 이의 용도 Download PDF

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KR102716931B1
KR102716931B1 KR1020237027761A KR20237027761A KR102716931B1 KR 102716931 B1 KR102716931 B1 KR 102716931B1 KR 1020237027761 A KR1020237027761 A KR 1020237027761A KR 20237027761 A KR20237027761 A KR 20237027761A KR 102716931 B1 KR102716931 B1 KR 102716931B1
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KR20230125099A (ko
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수아레즈 조안 세오아네
폴게이라 주딧 아니도
조 프란슨
진-필리프 줄리엔
스웨타 라만
Original Assignee
펀다시오 프리바다 인스티튜시오 카탈라나 드 르세르카 아이 에스투디스 아반카츠
펀다시오 프리바다 인스티튜트 드인베스티가시오 온콜로지카 데 발 헤브론
메디뮨 리미티드
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Application filed by 펀다시오 프리바다 인스티튜시오 카탈라나 드 르세르카 아이 에스투디스 아반카츠, 펀다시오 프리바다 인스티튜트 드인베스티가시오 온콜로지카 데 발 헤브론, 메디뮨 리미티드 filed Critical 펀다시오 프리바다 인스티튜시오 카탈라나 드 르세르카 아이 에스투디스 아반카츠
Priority to KR1020247033540A priority Critical patent/KR102784394B1/ko
Priority claimed from PCT/IB2017/001677 external-priority patent/WO2018115960A1/en
Publication of KR20230125099A publication Critical patent/KR20230125099A/ko
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0085Brain, e.g. brain implants; Spinal cord
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/248IL-6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • A61K2039/55527Interleukins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020237027761A 2016-12-19 2017-12-18 Lif에 대한 항체 및 이의 용도 Active KR102716931B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247033540A KR102784394B1 (ko) 2016-12-19 2017-12-18 Lif에 대한 항체 및 이의 용도

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP16382617.5 2016-12-19
EP16382617 2016-12-19
US201762467017P 2017-03-03 2017-03-03
US62/467,017 2017-03-03
EP17382683 2017-10-13
EP17382683.5 2017-10-13
PCT/IB2017/001677 WO2018115960A1 (en) 2016-12-19 2017-12-18 Antibodies against lif and uses thereof
KR1020197021098A KR102599557B1 (ko) 2016-12-19 2017-12-18 Lif에 대한 항체 및 이의 용도

Related Parent Applications (1)

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KR1020197021098A Division KR102599557B1 (ko) 2016-12-19 2017-12-18 Lif에 대한 항체 및 이의 용도

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020247033540A Division KR102784394B1 (ko) 2016-12-19 2017-12-18 Lif에 대한 항체 및 이의 용도

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KR20230125099A KR20230125099A (ko) 2023-08-28
KR102716931B1 true KR102716931B1 (ko) 2024-10-15

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KR1020237027761A Active KR102716931B1 (ko) 2016-12-19 2017-12-18 Lif에 대한 항체 및 이의 용도
KR1020247033540A Active KR102784394B1 (ko) 2016-12-19 2017-12-18 Lif에 대한 항체 및 이의 용도
KR1020197021098A Active KR102599557B1 (ko) 2016-12-19 2017-12-18 Lif에 대한 항체 및 이의 용도

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KR1020247033540A Active KR102784394B1 (ko) 2016-12-19 2017-12-18 Lif에 대한 항체 및 이의 용도
KR1020197021098A Active KR102599557B1 (ko) 2016-12-19 2017-12-18 Lif에 대한 항체 및 이의 용도

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US (2) US11390670B2 (enExample)
EP (2) EP4321219A3 (enExample)
JP (3) JP7100056B2 (enExample)
KR (3) KR102716931B1 (enExample)
CN (2) CN118652335A (enExample)
AU (1) AU2017381585B2 (enExample)
BR (1) BR112019012691A2 (enExample)
CA (1) CA3047528A1 (enExample)
CL (2) CL2019001717A1 (enExample)
DK (1) DK3555132T3 (enExample)
ES (1) ES2971126T3 (enExample)
FI (1) FI3555132T3 (enExample)
HR (1) HRP20240195T8 (enExample)
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IL (2) IL294088B2 (enExample)
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MX (2) MX2019007376A (enExample)
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PL (1) PL3555132T3 (enExample)
RS (1) RS65187B1 (enExample)
SA (1) SA519402119B1 (enExample)
SI (1) SI3555132T1 (enExample)
SM (1) SMT202400065T1 (enExample)
ZA (1) ZA201904533B (enExample)

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EP4321219A2 (en) 2024-02-14
DK3555132T3 (da) 2024-02-05
SI3555132T1 (sl) 2024-04-30
US11390670B2 (en) 2022-07-19
CA3047528A1 (en) 2018-06-28
MX2024003178A (es) 2024-03-25
AU2017381585A1 (en) 2019-07-18
KR20230125099A (ko) 2023-08-28
EP3555132B1 (en) 2023-11-15
CN111868086B (zh) 2024-07-16
CN118652335A (zh) 2024-09-17
LT3555132T (lt) 2024-02-26
US20230042095A1 (en) 2023-02-09
PL3555132T3 (pl) 2024-04-22
ZA201904533B (en) 2024-08-28
CN111868086A (zh) 2020-10-30
IL294088B1 (en) 2023-06-01
IL267450B (en) 2022-07-01
MX2019007376A (es) 2020-02-07
KR20240149987A (ko) 2024-10-15
RS65187B1 (sr) 2024-03-29
BR112019012691A2 (pt) 2019-11-19
ES2971126T3 (es) 2024-06-03
HRP20240195T1 (hr) 2024-04-26
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FI3555132T3 (fi) 2024-02-08
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IL267450A (en) 2019-08-29
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JP2024075682A (ja) 2024-06-04
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AU2017381585B2 (en) 2025-02-13
SMT202400065T1 (it) 2024-03-13
SA519402119B1 (ar) 2023-02-19
US20190352389A1 (en) 2019-11-21
KR102784394B1 (ko) 2025-03-19
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