KR102685289B1 - 개인의 생물학적 상태를 예측하기 위한 시스템, 방법 및 유전자 시그니처 - Google Patents
개인의 생물학적 상태를 예측하기 위한 시스템, 방법 및 유전자 시그니처 Download PDFInfo
- Publication number
- KR102685289B1 KR102685289B1 KR1020227023834A KR20227023834A KR102685289B1 KR 102685289 B1 KR102685289 B1 KR 102685289B1 KR 1020227023834 A KR1020227023834 A KR 1020227023834A KR 20227023834 A KR20227023834 A KR 20227023834A KR 102685289 B1 KR102685289 B1 KR 102685289B1
- Authority
- KR
- South Korea
- Prior art keywords
- delete delete
- genes
- gene
- data set
- computer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 96
- 230000004547 gene signature Effects 0.000 title claims description 129
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 191
- 230000014509 gene expression Effects 0.000 claims abstract description 71
- 230000000391 smoking effect Effects 0.000 claims abstract description 70
- -1 LINC00599 Proteins 0.000 claims abstract description 54
- 101150059521 AHRR gene Proteins 0.000 claims abstract description 52
- 102100026789 Aryl hydrocarbon receptor repressor Human genes 0.000 claims abstract description 52
- 101000693721 Homo sapiens SAM and SH3 domain-containing protein 1 Proteins 0.000 claims abstract description 49
- 102100025543 SAM and SH3 domain-containing protein 1 Human genes 0.000 claims abstract description 49
- 108010017222 Cyclin-Dependent Kinase Inhibitor p57 Proteins 0.000 claims abstract description 43
- 102000004480 Cyclin-Dependent Kinase Inhibitor p57 Human genes 0.000 claims abstract description 43
- 101001098529 Homo sapiens Proteinase-activated receptor 1 Proteins 0.000 claims abstract description 42
- 102100037136 Proteinase-activated receptor 1 Human genes 0.000 claims abstract description 42
- 101000609957 Homo sapiens PTB-containing, cubilin and LRP1-interacting protein Proteins 0.000 claims abstract description 39
- 102100039157 PTB-containing, cubilin and LRP1-interacting protein Human genes 0.000 claims abstract description 39
- 102100032532 C-type lectin domain family 10 member A Human genes 0.000 claims abstract description 37
- 102100023416 G-protein coupled receptor 15 Human genes 0.000 claims abstract description 37
- 101000942296 Homo sapiens C-type lectin domain family 10 member A Proteins 0.000 claims abstract description 37
- 101000829794 Homo sapiens G-protein coupled receptor 15 Proteins 0.000 claims abstract description 37
- 101000654676 Homo sapiens Semaphorin-6B Proteins 0.000 claims abstract description 35
- 102100032796 Semaphorin-6B Human genes 0.000 claims abstract description 35
- 101000986826 Homo sapiens P2Y purinoceptor 6 Proteins 0.000 claims abstract description 7
- 102100028074 P2Y purinoceptor 6 Human genes 0.000 claims abstract description 7
- 101000941865 Homo sapiens Leucine-rich repeat neuronal protein 3 Proteins 0.000 claims abstract 6
- 102100032657 Leucine-rich repeat neuronal protein 3 Human genes 0.000 claims abstract 6
- 238000012360 testing method Methods 0.000 claims description 105
- 102100031725 Cortactin-binding protein 2 Human genes 0.000 claims description 36
- 101000941045 Homo sapiens Cortactin-binding protein 2 Proteins 0.000 claims description 36
- 101001069617 Homo sapiens Probable G-protein coupled receptor 63 Proteins 0.000 claims description 26
- 102100033862 Probable G-protein coupled receptor 63 Human genes 0.000 claims description 26
- 230000008859 change Effects 0.000 claims description 18
- 230000000694 effects Effects 0.000 claims description 12
- 235000019505 tobacco product Nutrition 0.000 claims description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims description 7
- 238000004590 computer program Methods 0.000 claims description 7
- 238000003860 storage Methods 0.000 claims description 6
- 102100037709 Desmocollin-3 Human genes 0.000 abstract description 27
- 101000968042 Homo sapiens Desmocollin-2 Proteins 0.000 abstract description 27
- 101000880960 Homo sapiens Desmocollin-3 Proteins 0.000 abstract description 27
- 101000669460 Homo sapiens Toll-like receptor 5 Proteins 0.000 abstract description 17
- 102100039357 Toll-like receptor 5 Human genes 0.000 abstract description 17
- 239000000523 sample Substances 0.000 description 82
- 210000004369 blood Anatomy 0.000 description 57
- 239000008280 blood Substances 0.000 description 57
- 238000012549 training Methods 0.000 description 46
- 230000002068 genetic effect Effects 0.000 description 45
- 238000010200 validation analysis Methods 0.000 description 32
- 230000004044 response Effects 0.000 description 25
- 238000004891 communication Methods 0.000 description 22
- 241000699666 Mus <mouse, genus> Species 0.000 description 21
- 238000013145 classification model Methods 0.000 description 19
- 102100040739 Guanylate cyclase soluble subunit beta-1 Human genes 0.000 description 17
- 101001038731 Homo sapiens Guanylate cyclase soluble subunit beta-1 Proteins 0.000 description 17
- 101000709121 Homo sapiens Ral guanine nucleotide dissociation stimulator-like 1 Proteins 0.000 description 16
- 102100032665 Ral guanine nucleotide dissociation stimulator-like 1 Human genes 0.000 description 16
- 241000894007 species Species 0.000 description 16
- 102100029378 Follistatin-related protein 1 Human genes 0.000 description 15
- 102100037390 Genetic suppressor element 1 Human genes 0.000 description 15
- 101001062535 Homo sapiens Follistatin-related protein 1 Proteins 0.000 description 15
- 101001026271 Homo sapiens Genetic suppressor element 1 Proteins 0.000 description 15
- 102100040754 Guanylate cyclase soluble subunit alpha-1 Human genes 0.000 description 14
- 101001038755 Homo sapiens Guanylate cyclase soluble subunit alpha-1 Proteins 0.000 description 14
- 101000743488 Homo sapiens V-set and immunoglobulin domain-containing protein 4 Proteins 0.000 description 14
- 102100038296 V-set and immunoglobulin domain-containing protein 4 Human genes 0.000 description 14
- 238000013459 approach Methods 0.000 description 14
- 101000931590 Homo sapiens Prostaglandin F2 receptor negative regulator Proteins 0.000 description 13
- 101000796015 Homo sapiens Protein turtle homolog B Proteins 0.000 description 13
- 102100033256 Mitochondrial amidoxime reducing component 2 Human genes 0.000 description 13
- 101150010475 Mtarc2 gene Proteins 0.000 description 13
- 102100020864 Prostaglandin F2 receptor negative regulator Human genes 0.000 description 13
- 102100031337 Protein turtle homolog B Human genes 0.000 description 13
- 238000004458 analytical method Methods 0.000 description 13
- 102100025151 Adenylate kinase 8 Human genes 0.000 description 12
- 101001077073 Homo sapiens Adenylate kinase 8 Proteins 0.000 description 12
- 101000710893 Homo sapiens Putative uncharacterized protein encoded by LINC02915 Proteins 0.000 description 12
- 102100033870 Putative uncharacterized protein encoded by LINC02915 Human genes 0.000 description 12
- 102100026293 Asialoglycoprotein receptor 2 Human genes 0.000 description 11
- 102100032440 Beta-1,3-galactosyltransferase 2 Human genes 0.000 description 11
- 241000282412 Homo Species 0.000 description 11
- 101000785948 Homo sapiens Asialoglycoprotein receptor 2 Proteins 0.000 description 11
- 101000798387 Homo sapiens Beta-1,3-galactosyltransferase 2 Proteins 0.000 description 11
- 101001109700 Homo sapiens Nuclear receptor subfamily 4 group A member 1 Proteins 0.000 description 11
- 101000579300 Homo sapiens Prostaglandin F2-alpha receptor Proteins 0.000 description 11
- 101000645402 Homo sapiens Transmembrane protein 163 Proteins 0.000 description 11
- 102100022679 Nuclear receptor subfamily 4 group A member 1 Human genes 0.000 description 11
- 102100028248 Prostaglandin F2-alpha receptor Human genes 0.000 description 11
- 102100025764 Transmembrane protein 163 Human genes 0.000 description 11
- 238000009826 distribution Methods 0.000 description 11
- 101001018109 Homo sapiens Nucleotidyltransferase MB21D2 Proteins 0.000 description 10
- 101001098232 Homo sapiens P2Y purinoceptor 1 Proteins 0.000 description 10
- 101000893741 Homo sapiens Tissue alpha-L-fucosidase Proteins 0.000 description 10
- 101000679406 Homo sapiens Tubulin polymerization-promoting protein family member 3 Proteins 0.000 description 10
- 102100033052 Nucleotidyltransferase MB21D2 Human genes 0.000 description 10
- 102100037600 P2Y purinoceptor 1 Human genes 0.000 description 10
- 102100040526 Tissue alpha-L-fucosidase Human genes 0.000 description 10
- 102100022567 Tubulin polymerization-promoting protein family member 3 Human genes 0.000 description 10
- 238000010801 machine learning Methods 0.000 description 10
- 238000012545 processing Methods 0.000 description 10
- 239000000779 smoke Substances 0.000 description 10
- 102100031969 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Human genes 0.000 description 9
- 102100031132 Glucose-6-phosphate isomerase Human genes 0.000 description 9
- 108010070600 Glucose-6-phosphate isomerase Proteins 0.000 description 9
- 101000703728 Homo sapiens Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Proteins 0.000 description 9
- 101000971533 Homo sapiens Killer cell lectin-like receptor subfamily G member 1 Proteins 0.000 description 9
- 101000707218 Homo sapiens SH2 domain-containing protein 1B Proteins 0.000 description 9
- 101000909110 Homo sapiens Ultra-long-chain fatty acid omega-hydroxylase Proteins 0.000 description 9
- 102100021457 Killer cell lectin-like receptor subfamily G member 1 Human genes 0.000 description 9
- 102100031778 SH2 domain-containing protein 1B Human genes 0.000 description 9
- 102100024915 Ultra-long-chain fatty acid omega-hydroxylase Human genes 0.000 description 9
- 210000000601 blood cell Anatomy 0.000 description 9
- 238000010586 diagram Methods 0.000 description 9
- 230000035945 sensitivity Effects 0.000 description 9
- 231100000027 toxicology Toxicity 0.000 description 9
- 102100031654 Cytochrome c oxidase subunit 6B2 Human genes 0.000 description 8
- 101000922370 Homo sapiens Cytochrome c oxidase subunit 6B2 Proteins 0.000 description 8
- 101000582950 Homo sapiens Platelet factor 4 Proteins 0.000 description 8
- 101000713602 Homo sapiens T-box transcription factor TBX21 Proteins 0.000 description 8
- 101000818706 Homo sapiens Zinc finger protein 618 Proteins 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 8
- 102100030304 Platelet factor 4 Human genes 0.000 description 8
- 102100036840 T-box transcription factor TBX21 Human genes 0.000 description 8
- 102100021103 Zinc finger protein 618 Human genes 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 7
- 102100027634 Fibronectin type 3 and ankyrin repeat domains protein 1 Human genes 0.000 description 7
- 101000937169 Homo sapiens Fibronectin type 3 and ankyrin repeat domains protein 1 Proteins 0.000 description 7
- 101000933252 Homo sapiens Protein BEX3 Proteins 0.000 description 7
- 101001106082 Homo sapiens Receptor expression-enhancing protein 6 Proteins 0.000 description 7
- 102100025955 Protein BEX3 Human genes 0.000 description 7
- 102100021075 Receptor expression-enhancing protein 6 Human genes 0.000 description 7
- 238000013500 data storage Methods 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 7
- 235000019504 cigarettes Nutrition 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 238000007477 logistic regression Methods 0.000 description 6
- 238000007637 random forest analysis Methods 0.000 description 6
- 238000003491 array Methods 0.000 description 5
- 239000002299 complementary DNA Substances 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 238000013507 mapping Methods 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- 101150078635 18 gene Proteins 0.000 description 4
- 241000283984 Rodentia Species 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- 230000007704 transition Effects 0.000 description 4
- 238000011740 C57BL/6 mouse Methods 0.000 description 3
- 101150027068 DEGS1 gene Proteins 0.000 description 3
- 241000208125 Nicotiana Species 0.000 description 3
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 3
- 238000001790 Welch's t-test Methods 0.000 description 3
- 238000000205 computational method Methods 0.000 description 3
- 238000002790 cross-validation Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000002493 microarray Methods 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 238000012552 review Methods 0.000 description 3
- 238000012502 risk assessment Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000012795 verification Methods 0.000 description 3
- 230000007067 DNA methylation Effects 0.000 description 2
- 102100037643 EF-hand calcium-binding domain-containing protein 4A Human genes 0.000 description 2
- 101000880360 Homo sapiens EF-hand calcium-binding domain-containing protein 4A Proteins 0.000 description 2
- 101000976607 Homo sapiens Zinc finger protein 135 Proteins 0.000 description 2
- 102100023555 Zinc finger protein 135 Human genes 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000005094 computer simulation Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 231100000037 inhalation toxicity test Toxicity 0.000 description 2
- 239000006166 lysate Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000007427 paired t-test Methods 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000012358 sourcing Methods 0.000 description 2
- 238000012706 support-vector machine Methods 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- 101150000874 11 gene Proteins 0.000 description 1
- 102100030489 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Human genes 0.000 description 1
- 102100030786 3'-5' exoribonuclease 1 Human genes 0.000 description 1
- 102100040078 A-kinase anchor protein 5 Human genes 0.000 description 1
- 102100021580 Active regulator of SIRT1 Human genes 0.000 description 1
- 102100036006 Adenosine receptor A3 Human genes 0.000 description 1
- 102100031090 Alpha-catulin Human genes 0.000 description 1
- 102100021253 Antileukoproteinase Human genes 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 108700009171 B-Cell Lymphoma 3 Proteins 0.000 description 1
- 102100021570 B-cell lymphoma 3 protein Human genes 0.000 description 1
- 108091007065 BIRCs Proteins 0.000 description 1
- 102100021677 Baculoviral IAP repeat-containing protein 2 Human genes 0.000 description 1
- 101150072667 Bcl3 gene Proteins 0.000 description 1
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 description 1
- 102100040841 C-type lectin domain family 5 member A Human genes 0.000 description 1
- 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 102100040552 Claudin-23 Human genes 0.000 description 1
- 102100024338 Collagen alpha-3(VI) chain Human genes 0.000 description 1
- 102100028202 Cytochrome c oxidase subunit 6C Human genes 0.000 description 1
- 102100024460 DDB1- and CUL4-associated factor 8 Human genes 0.000 description 1
- 102100032249 Dystonin Human genes 0.000 description 1
- 102100039248 Elongation of very long chain fatty acids protein 7 Human genes 0.000 description 1
- 102100038591 Endothelial cell-selective adhesion molecule Human genes 0.000 description 1
- 102100024848 Epidermal retinol dehydrogenase 2 Human genes 0.000 description 1
- 102100021002 Eukaryotic translation initiation factor 5A-2 Human genes 0.000 description 1
- 102100023374 Forkhead box protein M1 Human genes 0.000 description 1
- 102100028689 Glucocorticoid-induced transcript 1 protein Human genes 0.000 description 1
- 102100036702 Glucosamine-6-phosphate isomerase 2 Human genes 0.000 description 1
- 102100034063 Glutathione hydrolase 7 Human genes 0.000 description 1
- 102100039874 Guanine nucleotide-binding protein G(z) subunit alpha Human genes 0.000 description 1
- 101150085568 HSPB6 gene Proteins 0.000 description 1
- 102100039170 Heat shock protein beta-6 Human genes 0.000 description 1
- 101001126430 Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Proteins 0.000 description 1
- 101000938755 Homo sapiens 3'-5' exoribonuclease 1 Proteins 0.000 description 1
- 101000890614 Homo sapiens A-kinase anchor protein 5 Proteins 0.000 description 1
- 101000783645 Homo sapiens Adenosine receptor A3 Proteins 0.000 description 1
- 101000922043 Homo sapiens Alpha-catulin Proteins 0.000 description 1
- 101000615334 Homo sapiens Antileukoproteinase Proteins 0.000 description 1
- 101000749314 Homo sapiens C-type lectin domain family 5 member A Proteins 0.000 description 1
- 101000749344 Homo sapiens Claudin-23 Proteins 0.000 description 1
- 101000909506 Homo sapiens Collagen alpha-3(VI) chain Proteins 0.000 description 1
- 101000861049 Homo sapiens Cytochrome c oxidase subunit 6C Proteins 0.000 description 1
- 101000832316 Homo sapiens DDB1- and CUL4-associated factor 8 Proteins 0.000 description 1
- 101001016186 Homo sapiens Dystonin Proteins 0.000 description 1
- 101000813103 Homo sapiens Elongation of very long chain fatty acids protein 7 Proteins 0.000 description 1
- 101000882622 Homo sapiens Endothelial cell-selective adhesion molecule Proteins 0.000 description 1
- 101000687614 Homo sapiens Epidermal retinol dehydrogenase 2 Proteins 0.000 description 1
- 101001002419 Homo sapiens Eukaryotic translation initiation factor 5A-2 Proteins 0.000 description 1
- 101000907578 Homo sapiens Forkhead box protein M1 Proteins 0.000 description 1
- 101001058426 Homo sapiens Glucocorticoid-induced transcript 1 protein Proteins 0.000 description 1
- 101001072480 Homo sapiens Glucosamine-6-phosphate isomerase 2 Proteins 0.000 description 1
- 101001002170 Homo sapiens Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial Proteins 0.000 description 1
- 101000926240 Homo sapiens Glutathione hydrolase 7 Proteins 0.000 description 1
- 101000887490 Homo sapiens Guanine nucleotide-binding protein G(z) subunit alpha Proteins 0.000 description 1
- 101000840258 Homo sapiens Immunoglobulin J chain Proteins 0.000 description 1
- 101001032342 Homo sapiens Interferon regulatory factor 7 Proteins 0.000 description 1
- 101000959664 Homo sapiens Interferon-induced protein 44-like Proteins 0.000 description 1
- 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 description 1
- 101001042351 Homo sapiens LIM and senescent cell antigen-like-containing domain protein 1 Proteins 0.000 description 1
- 101001054659 Homo sapiens Latent-transforming growth factor beta-binding protein 1 Proteins 0.000 description 1
- 101000941877 Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 1 Proteins 0.000 description 1
- 101000966782 Homo sapiens Lysophosphatidic acid receptor 1 Proteins 0.000 description 1
- 101000590691 Homo sapiens MAGUK p55 subfamily member 2 Proteins 0.000 description 1
- 101000573522 Homo sapiens MAP kinase-interacting serine/threonine-protein kinase 1 Proteins 0.000 description 1
- 101000615509 Homo sapiens MBT domain-containing protein 1 Proteins 0.000 description 1
- 101000978471 Homo sapiens Mast cell-expressed membrane protein 1 Proteins 0.000 description 1
- 101000731000 Homo sapiens Membrane-associated progesterone receptor component 1 Proteins 0.000 description 1
- 101000945411 Homo sapiens Metal transporter CNNM1 Proteins 0.000 description 1
- 101001111238 Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Proteins 0.000 description 1
- 101001125032 Homo sapiens Nucleotide-binding oligomerization domain-containing protein 1 Proteins 0.000 description 1
- 101001130862 Homo sapiens Oligoribonuclease, mitochondrial Proteins 0.000 description 1
- 101000735213 Homo sapiens Palladin Proteins 0.000 description 1
- 101001094017 Homo sapiens Phosphatase and actin regulator 3 Proteins 0.000 description 1
- 101001070790 Homo sapiens Platelet glycoprotein Ib alpha chain Proteins 0.000 description 1
- 101000874141 Homo sapiens Probable ATP-dependent RNA helicase DDX43 Proteins 0.000 description 1
- 101001056567 Homo sapiens Protein Jumonji Proteins 0.000 description 1
- 101000920935 Homo sapiens Protein eva-1 homolog B Proteins 0.000 description 1
- 101000743776 Homo sapiens R3H domain-containing protein 4 Proteins 0.000 description 1
- 101001111916 Homo sapiens RNA-binding protein 43 Proteins 0.000 description 1
- 101000823172 Homo sapiens RUN domain-containing protein 3A Proteins 0.000 description 1
- 101000744515 Homo sapiens Ras-related protein M-Ras Proteins 0.000 description 1
- 101000823237 Homo sapiens Reticulon-1 Proteins 0.000 description 1
- 101000885382 Homo sapiens Rho guanine nucleotide exchange factor 10-like protein Proteins 0.000 description 1
- 101000846198 Homo sapiens Ribitol 5-phosphate transferase FKRP Proteins 0.000 description 1
- 101000685296 Homo sapiens Seizure 6-like protein Proteins 0.000 description 1
- 101001077727 Homo sapiens Serine protease inhibitor Kazal-type 2 Proteins 0.000 description 1
- 101000716933 Homo sapiens Sterile alpha motif domain-containing protein 11 Proteins 0.000 description 1
- 101000879408 Homo sapiens Synaptonemal complex central element protein 1-like Proteins 0.000 description 1
- 101000658114 Homo sapiens Synaptotagmin-like protein 4 Proteins 0.000 description 1
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 description 1
- 101000891358 Homo sapiens Transcription elongation factor A protein-like 8 Proteins 0.000 description 1
- 101000843556 Homo sapiens Transcription factor HES-1 Proteins 0.000 description 1
- 101000979190 Homo sapiens Transcription factor MafB Proteins 0.000 description 1
- 101000894525 Homo sapiens Transforming growth factor-beta-induced protein ig-h3 Proteins 0.000 description 1
- 101000766345 Homo sapiens Tribbles homolog 3 Proteins 0.000 description 1
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 description 1
- 101000807337 Homo sapiens Ubiquitin-conjugating enzyme E2 B Proteins 0.000 description 1
- 101000880854 Homo sapiens Uridylate-specific endoribonuclease Proteins 0.000 description 1
- 101000860430 Homo sapiens Versican core protein Proteins 0.000 description 1
- 101000771655 Homo sapiens WD repeat and FYVE domain-containing protein 1 Proteins 0.000 description 1
- 102100029571 Immunoglobulin J chain Human genes 0.000 description 1
- 102100038070 Interferon regulatory factor 7 Human genes 0.000 description 1
- 102100039953 Interferon-induced protein 44-like Human genes 0.000 description 1
- 108091036429 KCNQ1OT1 Proteins 0.000 description 1
- 102100034845 KiSS-1 receptor Human genes 0.000 description 1
- 108010076800 Kisspeptin-1 Receptors Proteins 0.000 description 1
- 102100020677 Krueppel-like factor 4 Human genes 0.000 description 1
- 102100021754 LIM and senescent cell antigen-like-containing domain protein 1 Human genes 0.000 description 1
- 102100027000 Latent-transforming growth factor beta-binding protein 1 Human genes 0.000 description 1
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 1
- 102100032656 Leucine-rich repeat serine/threonine-protein kinase 1 Human genes 0.000 description 1
- 102100040607 Lysophosphatidic acid receptor 1 Human genes 0.000 description 1
- 102100026299 MAP kinase-interacting serine/threonine-protein kinase 1 Human genes 0.000 description 1
- 102100021282 MBT domain-containing protein 1 Human genes 0.000 description 1
- 102100023725 Mast cell-expressed membrane protein 1 Human genes 0.000 description 1
- 102100032399 Membrane-associated progesterone receptor component 1 Human genes 0.000 description 1
- 102100033593 Metal transporter CNNM1 Human genes 0.000 description 1
- 101000836750 Mus musculus E3 ubiquitin-protein ligase SIAH1A Proteins 0.000 description 1
- 101100377384 Mus musculus Znf704 gene Proteins 0.000 description 1
- 102100023948 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Human genes 0.000 description 1
- 102100029424 Nucleotide-binding oligomerization domain-containing protein 1 Human genes 0.000 description 1
- 102100032835 Oligoribonuclease, mitochondrial Human genes 0.000 description 1
- 102100035031 Palladin Human genes 0.000 description 1
- 102100035269 Phosphatase and actin regulator 3 Human genes 0.000 description 1
- 102100034173 Platelet glycoprotein Ib alpha chain Human genes 0.000 description 1
- 102100035724 Probable ATP-dependent RNA helicase DDX43 Human genes 0.000 description 1
- 108090001010 Protease-activated receptor 4 Proteins 0.000 description 1
- 102100025733 Protein Jumonji Human genes 0.000 description 1
- 102100031796 Protein eva-1 homolog B Human genes 0.000 description 1
- 102100020949 Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial Human genes 0.000 description 1
- 102100038383 R3H domain-containing protein 4 Human genes 0.000 description 1
- 239000013614 RNA sample Substances 0.000 description 1
- 102100023860 RNA-binding protein 43 Human genes 0.000 description 1
- 238000003559 RNA-seq method Methods 0.000 description 1
- 101150026963 RPS19BP1 gene Proteins 0.000 description 1
- 102100022665 RUN domain-containing protein 3A Human genes 0.000 description 1
- 102100039789 Ras-related protein M-Ras Human genes 0.000 description 1
- 101000832669 Rattus norvegicus Probable alcohol sulfotransferase Proteins 0.000 description 1
- 102100022647 Reticulon-1 Human genes 0.000 description 1
- 102100039777 Rho guanine nucleotide exchange factor 10-like protein Human genes 0.000 description 1
- 102100031774 Ribitol 5-phosphate transferase FKRP Human genes 0.000 description 1
- 102100023160 Seizure 6-like protein Human genes 0.000 description 1
- 102100025419 Serine protease inhibitor Kazal-type 2 Human genes 0.000 description 1
- 102100020927 Sterile alpha motif domain-containing protein 11 Human genes 0.000 description 1
- 101000879712 Streptomyces lividans Protease inhibitor Proteins 0.000 description 1
- 102100037485 Synaptonemal complex central element protein 1-like Human genes 0.000 description 1
- 102100035002 Synaptotagmin-like protein 4 Human genes 0.000 description 1
- 102100024333 Toll-like receptor 2 Human genes 0.000 description 1
- 102100040395 Transcription elongation factor A protein-like 8 Human genes 0.000 description 1
- 102100023234 Transcription factor MafB Human genes 0.000 description 1
- 102100021398 Transforming growth factor-beta-induced protein ig-h3 Human genes 0.000 description 1
- 102100026390 Tribbles homolog 3 Human genes 0.000 description 1
- 102100033726 Tumor necrosis factor receptor superfamily member 17 Human genes 0.000 description 1
- 102100037262 Ubiquitin-conjugating enzyme E2 B Human genes 0.000 description 1
- 102100037697 Uridylate-specific endoribonuclease Human genes 0.000 description 1
- 102100028437 Versican core protein Human genes 0.000 description 1
- 102100029468 WD repeat and FYVE domain-containing protein 1 Human genes 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004931 aggregating effect Effects 0.000 description 1
- 239000000809 air pollutant Substances 0.000 description 1
- 231100001243 air pollutant Toxicity 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010205 computational analysis Methods 0.000 description 1
- 238000013502 data validation Methods 0.000 description 1
- 238000003066 decision tree Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000004049 epigenetic modification Effects 0.000 description 1
- 231100000727 exposure assessment Toxicity 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000010305 frozen robust multiarray analysis Methods 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000013090 high-throughput technology Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 238000002952 image-based readout Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 101150044508 key gene Proteins 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000004901 leucine-rich repeat Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 238000010208 microarray analysis Methods 0.000 description 1
- 230000005486 microgravity Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000010239 partial least squares discriminant analysis Methods 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000010187 selection method Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000005586 smoking cessation Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000008280 toxic mechanism Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000011222 transcriptome analysis Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000002676 xenobiotic agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H70/00—ICT specially adapted for the handling or processing of medical references
- G16H70/60—ICT specially adapted for the handling or processing of medical references relating to pathologies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Data Mining & Analysis (AREA)
- Databases & Information Systems (AREA)
- Bioethics (AREA)
- Evolutionary Computation (AREA)
- Artificial Intelligence (AREA)
- Software Systems (AREA)
- Primary Health Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662394551P | 2016-09-14 | 2016-09-14 | |
| US62/394,551 | 2016-09-14 | ||
| KR1020197009475A KR102421109B1 (ko) | 2016-09-14 | 2017-05-30 | 개인의 생물학적 상태를 예측하기 위한 시스템, 방법 및 유전자 시그니처 |
| PCT/EP2017/063073 WO2018050299A1 (en) | 2016-09-14 | 2017-05-30 | Systems, methods, and gene signatures for predicting a biological status of an individual |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197009475A Division KR102421109B1 (ko) | 2016-09-14 | 2017-05-30 | 개인의 생물학적 상태를 예측하기 위한 시스템, 방법 및 유전자 시그니처 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20220103819A KR20220103819A (ko) | 2022-07-22 |
| KR102685289B1 true KR102685289B1 (ko) | 2024-07-16 |
Family
ID=59021473
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227023834A Active KR102685289B1 (ko) | 2016-09-14 | 2017-05-30 | 개인의 생물학적 상태를 예측하기 위한 시스템, 방법 및 유전자 시그니처 |
| KR1020197009475A Expired - Fee Related KR102421109B1 (ko) | 2016-09-14 | 2017-05-30 | 개인의 생물학적 상태를 예측하기 위한 시스템, 방법 및 유전자 시그니처 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197009475A Expired - Fee Related KR102421109B1 (ko) | 2016-09-14 | 2017-05-30 | 개인의 생물학적 상태를 예측하기 위한 시스템, 방법 및 유전자 시그니처 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20190244677A1 (https=) |
| EP (1) | EP3513344A1 (https=) |
| JP (2) | JP7022119B2 (https=) |
| KR (2) | KR102685289B1 (https=) |
| CN (1) | CN109643584A (https=) |
| CA (1) | CA3036597C (https=) |
| MX (1) | MX2019002316A (https=) |
| WO (1) | WO2018050299A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102517328B1 (ko) * | 2021-03-31 | 2023-04-04 | 주식회사 크라우드웍스 | 작업툴을 이용한 이미지 내 세포 분별에 관한 작업 수행 방법 및 프로그램 |
| CN113159571B (zh) * | 2021-04-20 | 2024-08-27 | 中国农业大学 | 一种跨境外来物种风险等级判定及智能识别方法及系统 |
| CN116103392A (zh) * | 2021-11-09 | 2023-05-12 | 中国医学科学院药物研究所 | 标志物sema6b在制备结直肠癌诊断及预后预测产品中的用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013032917A2 (en) * | 2011-08-29 | 2013-03-07 | Cardiodx, Inc. | Methods and compositions for determining smoking status |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3305919A1 (en) * | 2003-06-10 | 2018-04-11 | The Trustees of Boston University | Detection methods for disorders of the lung |
| JP2006314315A (ja) * | 2005-05-10 | 2006-11-24 | Synergenz Bioscience Ltd | 肺の機能と異常を調べるための方法と組成物 |
| WO2007103541A2 (en) * | 2006-03-09 | 2007-09-13 | The Trustees Of Boston University | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
| US20100055689A1 (en) * | 2008-03-28 | 2010-03-04 | Avrum Spira | Multifactorial methods for detecting lung disorders |
| WO2010056374A2 (en) * | 2008-11-17 | 2010-05-20 | Veracyte, Inc. | Methods and compositions of molecular profiling for disease diagnostics |
| WO2010099161A1 (en) * | 2009-02-26 | 2010-09-02 | The Ohio State University Research Foundation | Micrornas in never-smokers and related materials and methods |
| US20120245952A1 (en) * | 2011-03-23 | 2012-09-27 | University Of Rochester | Crowdsourcing medical expertise |
| WO2014039859A1 (en) * | 2012-09-06 | 2014-03-13 | Duke University | Diagnostic markers for platelet function and methods of use |
| PL3084664T3 (pl) * | 2013-12-16 | 2020-10-05 | Philip Morris Products S.A. | Układy i sposoby do przewidywania statusu palenia u osobnika |
| EP3169814B1 (en) * | 2014-07-14 | 2022-05-04 | Veracyte, Inc. | Methods for evaluating lung cancer status |
| EP3215170A4 (en) * | 2014-11-05 | 2018-04-25 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
-
2017
- 2017-05-30 EP EP17728486.6A patent/EP3513344A1/en not_active Withdrawn
- 2017-05-30 JP JP2019513943A patent/JP7022119B2/ja active Active
- 2017-05-30 US US16/333,157 patent/US20190244677A1/en not_active Abandoned
- 2017-05-30 WO PCT/EP2017/063073 patent/WO2018050299A1/en not_active Ceased
- 2017-05-30 KR KR1020227023834A patent/KR102685289B1/ko active Active
- 2017-05-30 CN CN201780050613.8A patent/CN109643584A/zh active Pending
- 2017-05-30 CA CA3036597A patent/CA3036597C/en active Active
- 2017-05-30 MX MX2019002316A patent/MX2019002316A/es unknown
- 2017-05-30 KR KR1020197009475A patent/KR102421109B1/ko not_active Expired - Fee Related
-
2022
- 2022-02-04 JP JP2022016224A patent/JP7275334B2/ja active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013032917A2 (en) * | 2011-08-29 | 2013-03-07 | Cardiodx, Inc. | Methods and compositions for determining smoking status |
Non-Patent Citations (1)
| Title |
|---|
| Yifei Shen 외, Scientific Reports, 2016.04.04., Vol.6, No.23984, pp1-17.* |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3513344A1 (en) | 2019-07-24 |
| JP7022119B2 (ja) | 2022-02-17 |
| CN109643584A (zh) | 2019-04-16 |
| MX2019002316A (es) | 2019-06-24 |
| WO2018050299A1 (en) | 2018-03-22 |
| BR112019004920A2 (pt) | 2019-06-04 |
| CA3036597A1 (en) | 2018-03-22 |
| CA3036597C (en) | 2023-03-28 |
| JP2019532410A (ja) | 2019-11-07 |
| KR20190046940A (ko) | 2019-05-07 |
| JP2022062189A (ja) | 2022-04-19 |
| KR102421109B1 (ko) | 2022-07-14 |
| US20190244677A1 (en) | 2019-08-08 |
| KR20220103819A (ko) | 2022-07-22 |
| JP7275334B2 (ja) | 2023-05-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Tian et al. | Benchmarking single cell RNA-sequencing analysis pipelines using mixture control experiments | |
| Tang et al. | Tumor origin detection with tissue-specific miRNA and DNA methylation markers | |
| EP2864919B1 (en) | Systems and methods for generating biomarker signatures with integrated dual ensemble and generalized simulated annealing techniques | |
| JP6320999B2 (ja) | ネットワークベースのバイオマーカシグネチャに関連するシステムおよび方法 | |
| Boulesteix et al. | Microarray-based classification and clinical predictors: on combined classifiers and additional predictive value | |
| US12060578B2 (en) | Systems and methods for associating compounds with physiological conditions using fingerprint analysis | |
| JP7275334B2 (ja) | 個人の生物学的ステータスを予測するためのシステム、方法および遺伝子シグネチャ | |
| US20250069693A1 (en) | Biomarkers for Age | |
| Boulesteix et al. | Added predictive value of high-throughput molecular data to clinical data and its validation | |
| US10580515B2 (en) | Systems and methods for generating biomarker signatures | |
| Yue et al. | A new approach to testing mediation of the microbiome at both the community and individual taxon levels | |
| Xie et al. | Improved metabolite prediction using microbiome data-based elastic net models | |
| Belcastro et al. | The sbv IMPROVER systems toxicology computational challenge: identification of human and species-independent blood response markers as predictors of smoking exposure and cessation status | |
| Shen et al. | Deciphering the impact of senescence in kidney transplant rejection: An integrative machine learning and multi-omics analysis via bulk and single-cell RNA sequencing | |
| Zhang et al. | The role of cellular senescence-related genes in Asthma: Insights from bioinformatics and animal experiments | |
| WO2022266259A9 (en) | Systems and methods for associating compounds with physiological conditions using fingerprint analysis | |
| Seth et al. | Type 2 diabetes mellitus associated pancreatic cancer prediction using combinations of machine learning models | |
| Tarca et al. | Human blood gene signature as a marker for smoking exposure: computational approaches of the top ranked teams in the sbv IMPROVER Systems Toxicology challenge | |
| Berndt et al. | A multivariate cell-based assay for blood-based diagnostics enhances lung cancer risk stratification | |
| BR112019004920B1 (pt) | Método implementado por computador para prever o status de fumo de um indivíduo e kit para prever o status de fumo de um indivíduo | |
| Belcastro et al. | Computational Toxicology | |
| Aloqaily et al. | Feature prioritisation on big genomic data for analysing gene-gene interactions | |
| Gibbs et al. | Case studies in data analysis | |
| KR20220111847A (ko) | 복합 생체 표지 네트워크 기반 질병 위험도 진단 방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A107 | Divisional application of patent | ||
| A201 | Request for examination | ||
| PA0104 | Divisional application for international application |
Comment text: Divisional Application for International Patent Patent event code: PA01041R01D Patent event date: 20220711 Application number text: 1020197009475 Filing date: 20190402 |
|
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20220711 Comment text: Request for Examination of Application |
|
| PG1501 | Laying open of application | ||
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20230320 Patent event code: PE09021S01D |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20230913 Patent event code: PE09021S01D |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20240509 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20240711 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 20240712 End annual number: 3 Start annual number: 1 |
|
| PG1601 | Publication of registration |