CA3036597C - Systems, methods, and gene signatures for predicting a biological status of an individual - Google Patents

Systems, methods, and gene signatures for predicting a biological status of an individual Download PDF

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Publication number
CA3036597C
CA3036597C CA3036597A CA3036597A CA3036597C CA 3036597 C CA3036597 C CA 3036597C CA 3036597 A CA3036597 A CA 3036597A CA 3036597 A CA3036597 A CA 3036597A CA 3036597 C CA3036597 C CA 3036597C
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Prior art keywords
genes
score
computer
data set
lrrn3
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CA3036597A
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English (en)
French (fr)
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CA3036597A1 (en
Inventor
Carine Poussin
Vincenzo BELCASTRO
Florian Martin
Stephanie Boue
Manuel Claude Peitsch
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Philip Morris Products SA
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Philip Morris Products SA
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00—ICT specially adapted for the handling or processing of medical references
    • G16H70/60—ICT specially adapted for the handling or processing of medical references relating to pathologies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Primary Health Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA3036597A 2016-09-14 2017-05-30 Systems, methods, and gene signatures for predicting a biological status of an individual Active CA3036597C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662394551P 2016-09-14 2016-09-14
US62/394551 2016-09-14
PCT/EP2017/063073 WO2018050299A1 (en) 2016-09-14 2017-05-30 Systems, methods, and gene signatures for predicting a biological status of an individual

Publications (2)

Publication Number Publication Date
CA3036597A1 CA3036597A1 (en) 2018-03-22
CA3036597C true CA3036597C (en) 2023-03-28

Family

ID=59021473

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3036597A Active CA3036597C (en) 2016-09-14 2017-05-30 Systems, methods, and gene signatures for predicting a biological status of an individual

Country Status (8)

Country Link
US (1) US20190244677A1 (https=)
EP (1) EP3513344A1 (https=)
JP (2) JP7022119B2 (https=)
KR (2) KR102685289B1 (https=)
CN (1) CN109643584A (https=)
CA (1) CA3036597C (https=)
MX (1) MX2019002316A (https=)
WO (1) WO2018050299A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102517328B1 (ko) * 2021-03-31 2023-04-04 주식회사 크라우드웍스 작업툴을 이용한 이미지 내 세포 분별에 관한 작업 수행 방법 및 프로그램
CN113159571B (zh) * 2021-04-20 2024-08-27 中国农业大学 一种跨境外来物种风险等级判定及智能识别方法及系统
CN116103392A (zh) * 2021-11-09 2023-05-12 中国医学科学院药物研究所 标志物sema6b在制备结直肠癌诊断及预后预测产品中的用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3305919A1 (en) * 2003-06-10 2018-04-11 The Trustees of Boston University Detection methods for disorders of the lung
JP2006314315A (ja) * 2005-05-10 2006-11-24 Synergenz Bioscience Ltd 肺の機能と異常を調べるための方法と組成物
WO2007103541A2 (en) * 2006-03-09 2007-09-13 The Trustees Of Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
US20100055689A1 (en) * 2008-03-28 2010-03-04 Avrum Spira Multifactorial methods for detecting lung disorders
WO2010056374A2 (en) * 2008-11-17 2010-05-20 Veracyte, Inc. Methods and compositions of molecular profiling for disease diagnostics
WO2010099161A1 (en) * 2009-02-26 2010-09-02 The Ohio State University Research Foundation Micrornas in never-smokers and related materials and methods
US20120245952A1 (en) * 2011-03-23 2012-09-27 University Of Rochester Crowdsourcing medical expertise
EP2751290A4 (en) * 2011-08-29 2015-07-15 Cardiodx Inc METHOD AND COMPOSITIONS FOR DETERMINING A SMOKE STATUS
WO2014039859A1 (en) * 2012-09-06 2014-03-13 Duke University Diagnostic markers for platelet function and methods of use
PL3084664T3 (pl) * 2013-12-16 2020-10-05 Philip Morris Products S.A. Układy i sposoby do przewidywania statusu palenia u osobnika
EP3169814B1 (en) * 2014-07-14 2022-05-04 Veracyte, Inc. Methods for evaluating lung cancer status
EP3215170A4 (en) * 2014-11-05 2018-04-25 Veracyte, Inc. Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data

Also Published As

Publication number Publication date
KR102685289B1 (ko) 2024-07-16
EP3513344A1 (en) 2019-07-24
JP7022119B2 (ja) 2022-02-17
CN109643584A (zh) 2019-04-16
MX2019002316A (es) 2019-06-24
WO2018050299A1 (en) 2018-03-22
BR112019004920A2 (pt) 2019-06-04
CA3036597A1 (en) 2018-03-22
JP2019532410A (ja) 2019-11-07
KR20190046940A (ko) 2019-05-07
JP2022062189A (ja) 2022-04-19
KR102421109B1 (ko) 2022-07-14
US20190244677A1 (en) 2019-08-08
KR20220103819A (ko) 2022-07-22
JP7275334B2 (ja) 2023-05-17

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