KR102636786B1 - 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법 - Google Patents

줄기 세포 배양을 위한 유도 배지 및 방법 및 요법 Download PDF

Info

Publication number
KR102636786B1
KR102636786B1 KR1020237030185A KR20237030185A KR102636786B1 KR 102636786 B1 KR102636786 B1 KR 102636786B1 KR 1020237030185 A KR1020237030185 A KR 1020237030185A KR 20237030185 A KR20237030185 A KR 20237030185A KR 102636786 B1 KR102636786 B1 KR 102636786B1
Authority
KR
South Korea
Prior art keywords
certain embodiments
cells
concentration
mesenchymal stem
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020237030185A
Other languages
English (en)
Korean (ko)
Other versions
KR20230132621A (ko
Inventor
알린 베탕쿠르
Original Assignee
샌바이오, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 샌바이오, 인크. filed Critical 샌바이오, 인크.
Priority to KR1020247004511A priority Critical patent/KR102766202B1/ko
Publication of KR20230132621A publication Critical patent/KR20230132621A/ko
Application granted granted Critical
Publication of KR102636786B1 publication Critical patent/KR102636786B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0043—Medium free of human- or animal-derived components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C12N2500/92—Medium free of human- or animal-derived components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/05—Adjuvants
    • C12N2501/052—Lipopolysaccharides [LPS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/14—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2304—Interleukin-4 (IL-4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2313—Interleukin-13 (IL-13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
KR1020237030185A 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법 Active KR102636786B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247004511A KR102766202B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14/504,399 US20160095885A1 (en) 2014-10-01 2014-10-01 Induction Medium & Methods for Stem Cell Culture & Therapy
US14/504,399 2014-10-01
PCT/US2015/052029 WO2016053758A1 (en) 2014-10-01 2015-09-24 Induction medium and methods for stem cell culture and therapy
KR1020237019063A KR102576875B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020237019063A Division KR102576875B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020247004511A Division KR102766202B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법

Publications (2)

Publication Number Publication Date
KR20230132621A KR20230132621A (ko) 2023-09-15
KR102636786B1 true KR102636786B1 (ko) 2024-02-14

Family

ID=55631287

Family Applications (10)

Application Number Title Priority Date Filing Date
KR1020237030185A Active KR102636786B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020207016164A Active KR102275640B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020217041459A Active KR102445071B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020177011391A Active KR102163403B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020217030644A Active KR102342470B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020217020769A Active KR102316952B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020247004511A Active KR102766202B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020237019063A Active KR102576875B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020257003641A Pending KR20250023596A (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020227031764A Active KR102542748B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법

Family Applications After (9)

Application Number Title Priority Date Filing Date
KR1020207016164A Active KR102275640B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020217041459A Active KR102445071B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020177011391A Active KR102163403B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020217030644A Active KR102342470B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020217020769A Active KR102316952B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020247004511A Active KR102766202B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020237019063A Active KR102576875B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020257003641A Pending KR20250023596A (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법
KR1020227031764A Active KR102542748B1 (ko) 2014-10-01 2015-09-24 줄기 세포 배양을 위한 유도 배지 및 방법 및 요법

Country Status (11)

Country Link
US (6) US20160095885A1 (enExample)
EP (2) EP4234032A3 (enExample)
JP (4) JP6890538B2 (enExample)
KR (10) KR102636786B1 (enExample)
CN (1) CN107002029A (enExample)
AU (4) AU2015324241B2 (enExample)
CA (2) CA3210154A1 (enExample)
ES (1) ES2961691T3 (enExample)
MX (1) MX2017004288A (enExample)
RU (1) RU2717983C2 (enExample)
WO (1) WO2016053758A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160095885A1 (en) 2014-10-01 2016-04-07 WibiWorks Therapeutics, Inc. Induction Medium & Methods for Stem Cell Culture & Therapy
JP7168448B2 (ja) 2015-12-07 2022-11-09 コロラド ステート ユニバーシティー リサーチ ファウンデーション 感染創傷のための活性化幹細胞を含む組成物
CA3019574C (en) * 2016-03-31 2025-09-23 Sanbio Inc Medium, methods, cells and secreted factors for stem cell culture and therapy
WO2018067925A1 (en) * 2016-10-06 2018-04-12 Transgenex Nanobiotech, Inc. Methods for cancer stem cell (csc) expansion
CN110121553A (zh) * 2016-10-27 2019-08-13 纽约哥伦比亚大学董事会 免疫抑制性间充质细胞及其形成方法
JP7237301B2 (ja) * 2016-12-16 2023-03-13 有限会社大阪空気機械サービス 組織治癒剤
JP7363003B2 (ja) * 2018-06-11 2023-10-18 ヘルス、アンド、バイオテック、フランス（アッシュ、アンド、ベー、フランス） 間葉系幹細胞由来細胞外小胞
WO2020045399A1 (ja) * 2018-08-29 2020-03-05 株式会社Ｒｅｇｅｎｅ Ｐｈａｒｍ がんの治療のための医薬組成物
MX2021004924A (es) 2018-10-30 2021-08-16 Vitabolus Inc Administracion oral de celulas terapeuticas de mamiferos.
WO2021007180A1 (en) * 2019-07-05 2021-01-14 Case Western Reserve University Priming media and methods for stem cell culture and therapy
US20230257713A1 (en) * 2020-07-16 2023-08-17 Shanghai Jiaotong University Immunotherapy method of targeted chemokine and cytokine delivery by mesenchymal stem cell
KR102460408B1 (ko) * 2020-07-23 2022-10-28 포항공과대학교 산학협력단 줄기세포 시트를 제조하는 방법
TWI888659B (zh) * 2021-10-13 2025-07-01 芯芮生技開發股份有限公司 幹細胞條件培養基於製備抑制癌症組成物的用途
KR20250076941A (ko) * 2023-11-23 2025-05-30 (주) 넥셀 인간 전분화능 줄기세포 유래 심장 오가노이드를 이용해 허혈-재관류 손상에 의해 성체 급성 심근경색 및 심부전 질환이 유도된 체외 질환 모사 모델 제조 방법 및 이를 통해 제조된 체외 질환 모사 모델

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855510B2 (en) * 2001-03-20 2005-02-15 Dana Farber Cancer Institute, Inc. Pharmaceuticals and methods for treating hypoxia and screening methods therefor
EP2298861B1 (en) 2004-03-22 2017-09-13 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
WO2005113751A1 (en) 2004-05-14 2005-12-01 Becton, Dickinson And Company Cell culture environments for the serum-free expansion of mesenchymal stem cells
WO2007136673A2 (en) 2006-05-19 2007-11-29 Medistem Laboratories, Inc. Treatment of disc degenerative disease and compositions for same
WO2009114860A2 (en) 2008-03-14 2009-09-17 The Board Of Trustees Of The University Of Illinois Activated mesenchymal stem cells for the prevention and repair of inflammatory states
DK2285951T3 (en) 2008-05-28 2018-10-22 Univ Ramot TREATMENT OF CNS DISEASES OF CNS DISEASES
CN101407790B (zh) * 2008-10-30 2010-09-29 浙江大学 一种增强人骨髓间充质干细胞旁分泌能力的处理方法
WO2011068792A2 (en) * 2009-12-01 2011-06-09 The Regents Of The University Of California Compositions and methods for making and using bone marrow mesenchymal stem cells and erythroid progenitor cells
WO2012051210A2 (en) 2010-10-11 2012-04-19 The Administrators Of The Tulane Educational Fund Mesenchymal stem cells and related therapies
US8785190B2 (en) 2011-04-06 2014-07-22 Sanbio, Inc. Methods and compositions for modulating peripheral immune function
WO2012150707A1 (ja) 2011-05-02 2012-11-08 国立大学法人熊本大学 幹細胞からインスリン産生細胞への分化誘導を促進する低分子化合物および該化合物を用いた幹細胞からインスリン産生細胞への分化誘導方法
KR102108245B1 (ko) * 2011-11-30 2020-05-08 아스텔라스 인스티튜트 포 리제너러티브 메디슨 중간엽 간질 세포 및 이에 관련된 용도
EP2872619B1 (en) * 2012-07-11 2018-02-14 Imstem Biotechnology Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
US20160095885A1 (en) 2014-10-01 2016-04-07 WibiWorks Therapeutics, Inc. Induction Medium & Methods for Stem Cell Culture & Therapy
CN104845933A (zh) * 2015-05-15 2015-08-19 大连理工大学 一种增强脂肪间充质干细胞免疫学性能和迁移能力的方法
CA3019574C (en) 2016-03-31 2025-09-23 Sanbio Inc Medium, methods, cells and secreted factors for stem cell culture and therapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PLoS ONE, vol.7(6), e39592(2012)
Stem Cells. vol.26(1), pp.99~107(2008)

Also Published As

Publication number Publication date
KR20240024322A (ko) 2024-02-23
AU2023203680B2 (en) 2025-11-20
US10273449B2 (en) 2019-04-30
RU2717983C2 (ru) 2020-03-27
US20160097038A1 (en) 2016-04-07
RU2017114574A3 (enExample) 2019-04-17
KR20250023596A (ko) 2025-02-18
AU2023203680A1 (en) 2023-07-06
US20160201036A1 (en) 2016-07-14
AU2015324241A1 (en) 2017-05-18
KR20210088010A (ko) 2021-07-13
US9321994B1 (en) 2016-04-26
AU2021201433C1 (en) 2023-10-05
AU2021201433A1 (en) 2021-03-25
CA3210154A1 (en) 2016-04-07
KR102342470B1 (ko) 2021-12-24
MX2017004288A (es) 2017-10-23
KR20210121290A (ko) 2021-10-07
KR102163403B1 (ko) 2020-10-08
WO2016053758A1 (en) 2016-04-07
CA3000334C (en) 2025-10-07
KR102576875B1 (ko) 2023-09-08
KR20230132621A (ko) 2023-09-15
EP3201318B1 (en) 2023-07-26
EP4234032A3 (en) 2023-09-27
US20160095885A1 (en) 2016-04-07
JP7672867B2 (ja) 2025-05-08
EP3201318A4 (en) 2018-05-30
KR102316952B1 (ko) 2021-10-25
JP2023109837A (ja) 2023-08-08
US20190002823A1 (en) 2019-01-03
KR20210156353A (ko) 2021-12-24
RU2017114574A (ru) 2018-11-07
US20160194602A1 (en) 2016-07-07
KR102275640B1 (ko) 2021-07-08
KR20170084042A (ko) 2017-07-19
JP2025131663A (ja) 2025-09-09
EP3201318A1 (en) 2017-08-09
US20210062140A1 (en) 2021-03-04
AU2015324241B2 (en) 2021-01-21
ES2961691T3 (es) 2024-03-13
KR20220130833A (ko) 2022-09-27
CN107002029A (zh) 2017-08-01
KR102542748B1 (ko) 2023-06-14
JP6890538B2 (ja) 2021-06-18
AU2021201433B2 (en) 2023-03-16
US11046929B2 (en) 2021-06-29
JP7773502B2 (ja) 2025-11-19
CA3000334A1 (en) 2016-04-07
AU2025238026A1 (en) 2025-10-16
KR102766202B1 (ko) 2025-02-10
KR102445071B1 (ko) 2022-09-19
KR20200068758A (ko) 2020-06-15
JP2017531425A (ja) 2017-10-26
EP4234032A2 (en) 2023-08-30
JP2021113205A (ja) 2021-08-05
KR20230091185A (ko) 2023-06-22

Similar Documents

Publication Publication Date Title
JP7773502B2 (ja) 幹細胞培養および療法のための誘導培地および方法
AU2020311877B2 (en) Priming media and methods for stem cell culture and therapy
JP2014503176A (ja) 幹細胞培養培地および方法
CN113574166B (zh) 中胚层杀伤（mk）细胞

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20230905

Application number text: 1020237019063

Filing date: 20230607

A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20230906

Comment text: Request for Examination of Application

PG1501 Laying open of application
E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20231115

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20240208

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20240208

End annual number: 3

Start annual number: 1

PG1601 Publication of registration