KR102558992B1 - Medicinal liquid pumping apparatus and preparing method for medicinal liquid injection using the same - Google Patents

Abstract

A chemical liquid pumping device according to an exemplary embodiment includes: a chamber in which an inner space not filled with a chemical liquid and an injection port connected to the inner space are formed; a plunger disposed inside the chamber so that the internal space has a predetermined volume; and a pressing operation unit configured to press the plunger so that the volume of the inner space is reduced.

Description

Medical liquid pumping device and preparation method for liquid injection using the same

The present disclosure relates to a drug solution pumping device and a method for preparing a drug solution injection using the same.

BACKGROUND ART In order to supply a drug to a patient, a drug solution injection device for injecting a liquid drug solution (eg, an injection solution) into a patient is known. Using the drug solution injection device, the drug solution in a predetermined storage space passes through a passage connected to the patient (for example, an inner space of a tube and an injection needle) and is introduced into the patient's body.

A conventional chemical injection device injects a chemical solution through a process of expansion and contraction. Specifically, when the inside of the drug injection device is filled with the drug solution, the space filled with the drug solution expands and pressure is generated to contract the space filled with the drug solution, so that the space returns to its original volume. The drug solution inside the device can be injected into the patient. For example, a drug injection device is known that generates pressure for contraction of the stomach by using an elastic body such as a spring type, a balloon type, or an air compression type or compressive energy of air. In addition, a lubricant for sliding the plunger may be applied to the inner surface of the chamber of the liquid injection device.

In addition, in order to inject the drug solution into the body of a patient using the drug injection device, it is necessary to fill the drug solution inside the drug injection device, and to fill the tube of the drug solution injection device with saline solution or the drug solution to remove air inside the tube.

Korean Patent Publication No. 10-2019-0044478 (published on April 30, 2019)

Ewha Biomedics Co., Ltd., a Korean company, has previously sold a drug injection device called "ANAPA", and at least some embodiments of the present disclosure present a more innovative drug injection device that is an upgraded version of the existing "ANAPA" device.

In a conventional chemical injection device, while a chemical solution is filled into an inner space of a chamber of the chemical solution injection device, a plunger slides along an inner surface of the chamber, and the inner space is expanded at the same time. In this process, since the plunger slides along the inner surface of the chamber, the lubricant applied to the inner surface may be damaged or entangled and deformed. Thereafter, when the plunger slides once more along the same inner surface in the opposite direction to the moving direction in the expansion process while the inner space is contracted for the injection of the chemical solution, the frictional resistance acting on the plunger is increased. In addition, it is very difficult to design the frictional resistance because the extent to which the lubricant is damaged or entangled and deformed cannot be controlled, and the frictional resistance varies depending on which part of the inner surface the plunger is in contact with during the contraction process. Therefore, this deformation of the lubricant film makes it difficult to set a constant frictional force applied to the plunger during the contraction process, causing a problem in that it is difficult to set a constant flow rate of the chemical solution. Embodiments of the liquid medicine pumping device of the present disclosure solve these problems of the prior art.

In addition, the conventional chemical solution injection device has a problem in that a very cumbersome operation is required to perform a priming operation. If a conventional chemical injection device performs a priming operation using a pressurizing operation unit (for example, an air compression type pressurizing unit) that generates a pressing force during the liquid injection process, there is a problem in that the operation of the pressurizing operation unit must be started. Embodiments of the method for preparing drug solution injection of the present disclosure solve this problem of the prior art.

In addition, when the plunger of the liquid injection device is placed in one position in the chamber for a considerable period of time, the inner surface of the chamber may adhere to the plunger. In particular, when a lubricant is applied to the inner surface of the chamber, the adhesion becomes stronger due to the influence of the lubricant, and when the liquid injection device is used, a pressure higher than a preset pressure is required to directly move the plunger in the pressing direction for the contraction process. Accordingly, it may be difficult to start the normal operation of the drug injection device, and a problem may occur in that the set drug injection speed is not maintained during the operation start process. Embodiments of the preparation method for liquid injection of the present disclosure solve this problem.

In order to prevent the above-described deformation of the lubricant film, one aspect of the present disclosure provides embodiments of a liquid chemical pumping device. A chemical liquid pumping device according to a representative embodiment includes a chamber in which an inner space not filled with a chemical liquid and an injection port connected to the inner space are formed; a plunger disposed inside the chamber so that the internal space has a predetermined volume; and a pressing operation unit configured to press the plunger so that the volume of the inner space is reduced.

In one embodiment, an inlet connected to the inner space and different from the inlet may be formed in the chamber. The chemical liquid pumping device may further include a one-way valve disposed at the inlet and configured to allow a flow of the chemical liquid moving from the outside into the inner space and to block a flow of the chemical liquid moving from the inner space to the outside.

In one embodiment, a vent hole may be formed in the chamber. The chemical liquid pumping device may further include a hydrophobic filter configured to allow passage of air discharged from the inner space through the vent hole and prevent passage of liquid.

In order to solve the problems of the above-mentioned priming operation and the above-mentioned problems of starting operation due to adhesion of the plunger of the above-mentioned chemical liquid injection device, another aspect of the present disclosure provides embodiments of a preparation method for chemical liquid injection. A chemical solution injection device used in a preparation method for chemical solution injection according to a representative embodiment includes a chamber having an inner space and having different inlets and inlets connected to the inner space; a plunger disposed inside the chamber so that the internal space has a predetermined volume; a pressing operation unit configured to press the plunger so that the volume of the inner space is reduced; and a chemical liquid flow line having a chemical liquid flow passage connected to the inlet. A preparation method for injecting a chemical solution according to a representative embodiment includes an additional chemical solution filling step in which, in a state in which the inner space is filled with the chemical solution, additional chemical solution is introduced into the inner space through the inlet and the plunger is moved to increase the volume of the inner space, thereby generating a pressure pushing the chemical solution by the plunger; and a priming step of moving the chemical liquid by the pressure and filling the chemical liquid flow passage.

In one embodiment of the chemical solution pumping device, a plunger is disposed inside the chamber so that an internal space not filled with the chemical solution has a predetermined volume, so that the plunger is not slid on the inner surface of the chamber when the user's chemical liquid is filled to the predetermined volume, thereby minimizing damage to the lubricant film applied to the inner surface of the chamber. Accordingly, it is possible to set a constant frictional force applied to the plunger during the above-described contraction process for injecting the drug solution into the patient, and the drug solution can be injected into the patient at a set constant rate of inflow of the drug solution.

According to an embodiment of the chemical solution injection preparation method, even before the operation of the pressurizing operation unit starts, the chemical solution additionally introduced into the inner space (the additional amount of the chemical solution) is moved along the connection passage due to the pressurization in the priming step, so that the priming operation can be performed quickly and easily. In addition, according to an embodiment of the preparation method for chemical solution injection, when the user fills the internal space with the additional inflow amount of the chemical solution, pressure to push the plunger in the direction in which the plunger should be moved for the priming step is generated without additional manipulation, so that the priming operation can be conveniently performed with minimal actions.

If the plunger is moved in the pressing direction for the contraction process immediately from the initial stop state, a pressure higher than the set pressure may be required due to the influence of the above-mentioned adhesion. In one embodiment of the method for preparing the chemical solution injection to prevent this, the above-described adhesion may be released by initially moving the plunger slightly in a direction opposite to the pressing direction in the additional chemical solution filling step. Accordingly, when the plunger is pushed in the pressing direction with a predetermined pressure after the additional liquid filling step, the above-described adhesion is not affected, so that the normal operation of the liquid pumping device or the liquid liquid injection device can be started naturally, and the liquid liquid can be injected into the patient at a constant liquid injection rate without additional pressure.

1 is a conceptual diagram showing the entire system of a chemical solution injection device 1 according to an embodiment of the present disclosure.
2 is a cross-sectional view of the liquid chemical pumping device 100 according to the first embodiment.
3 is a cross-sectional view of the liquid chemical pumping device 100' according to the second embodiment.
4 is a cross-sectional view of a liquid chemical pumping device 100'' according to a third embodiment.
5 is a cross-sectional view of a liquid chemical pumping device 100''' according to a fourth embodiment.
6 is a flowchart showing a method for preparing a chemical solution injection according to an embodiment of the present disclosure.
FIG. 7 is a cross-sectional view of the chemical liquid pumping device 100 showing a state in which the chemical liquid M is being filled into the chamber 110 in the chamber filling step (S10) of the preparation method of FIG. 6 .
FIG. 8 is a cross-sectional view of the chemical solution pumping device 100 showing how the chemical solution M is completely filled into the chamber 110 in the chamber filling step (S10) of the preparation method of FIG. 6 .
FIG. 9 is a cross-sectional view of the chemical solution pumping device 100 showing how an additional chemical solution M is filled into the chamber 110 in the additional chemical solution filling step (S20) of the preparation method of FIG. 6 .
FIG. 10 is a cross-sectional view of the chemical liquid pumping device 100 showing how priming is performed by the chemical liquid M in the priming step (S30) of the preparation method of FIG. 6 .

Embodiments of the present disclosure are illustrated for the purpose of explaining the technical idea of the present disclosure. The scope of rights according to the present disclosure is not limited to the specific description of the embodiments or these embodiments presented below.

All technical terms and scientific terms used in this disclosure have meanings commonly understood by those of ordinary skill in the art to which this disclosure belongs, unless otherwise defined. All terms used in this disclosure are selected for the purpose of more clearly describing the disclosure and are not selected to limit the scope of rights according to the disclosure.

Expressions such as “comprising,” “including,” “having,” and the like used in this disclosure are to be understood as open-ended terms that connote the possibility of including other embodiments, unless otherwise stated in a phrase or sentence in which the expression is included.

Expressions in the singular form described in this disclosure may include plural meanings unless otherwise stated, and this applies equally to expressions in the singular form described in the claims.

Expressions such as "first" and "second" used in the present disclosure are used to distinguish a plurality of elements from each other, and do not limit the order or importance of the elements.

"Upstream" and "downstream" used in the present disclosure are defined based on the direction in which the chemical solution flows when the chemical solution pumping device 100 pressurizes the drug solution. Specifically, the direction of the arrow F in FIG. 1 is defined as the downstream direction, and the direction opposite to the downstream direction is defined as the upstream direction.

Hereinafter, embodiments of the present disclosure will be described with reference to the accompanying drawings. In the accompanying drawings, identical or corresponding elements are given the same reference numerals. In addition, in the description of the following embodiments, overlapping descriptions of the same or corresponding components may be omitted. However, omission of a description of a component does not intend that such a component is not included in an embodiment.

1 is a conceptual diagram showing the entire system of a chemical solution injection device 1 according to an embodiment of the present disclosure.

Referring to FIG. 1 , a chemical solution injection device 1 includes a chemical solution pumping device 100 . The chemical solution injection device 1 may include a chemical solution flow unit 300 connected to the chemical solution pumping device 100 .

The chemical solution pumping device 100 includes a chamber 110 in which an inner space 110s not filled with the chemical solution is formed. An inlet 110a connected to the inner space 110s is formed in the chamber 110 . The chemical solution flow unit 300 may be connected to the inlet 110a. After filling the inner space 110s with the chemical solution, the chemical solution may be discharged to the chemical solution flow unit 300 through the injection port 110a.

The chemical liquid pumping device 100 includes a plunger 120 disposed inside the chamber 110s so that the internal space 110s has a predetermined volume. The plunger 120 is configured to be movable inside the chamber 110 . The plunger 120 may pressurize the liquid inside the chamber 110 by moving in a predetermined pressing direction.

The chemical liquid pumping device 100 includes a pressure operation unit 130 configured to press the plunger 120 so that the volume of the inner space 110s decreases. The pressing operation unit 130 may provide power so that the plunger 120 moves in the pressing direction. For example, the pressurization operation unit 130 may be configured to pressurize the plunger 120 in the pressurization direction by gas pressure generated inside through gas activation or a balloon. As another example, the pressing operation unit 130 may move the plunger 120 in the pressing direction with the force of an elastic body such as a spring. In this embodiment, the pressure operation unit 130 pressurizes the plunger 120 by generating gas (eg, carbon dioxide) therein by gas activation.

The chemical solution flow unit 300 includes a chemical solution flow line 320 . The chemical solution flow unit 300 may include an air filter 330 and a chemical solution transfer pipe device 340 .

In order to inject the drug into a patient using the drug injection device 1, a priming process, which is a preparation process for drug injection, and a drug injection process may be performed. During the priming process, the priming liquid is allowed to flow along the chemical liquid flow line 320 . In a state where the end cap 500 is coupled to the downstream end of the chemical liquid flow part 300, the priming process may proceed. The priming process may be performed in a state in which the patient and the drug injection device are separated. The priming liquid flowing along the chemical liquid flow line 320 is introduced into the air filter and the capillary device for adjusting the flow rate (eg, filter-integrated chemical liquid transfer pipe device) 330 and 340 . The drug solution injection device 1 may include an end cap 500 detachably connected to the downstream side of the drug solution transfer pipe device 340 . Air inside the chemical liquid flow line 320 may be discharged to the outside through the end cap 500 . In this embodiment, after the chemical liquid is filled in the chemical liquid pumping device 100, the chemical liquid may be used as the priming liquid.

The end cap 500 is configured so that the air passing through the chemical liquid transfer pipe device 340 and the liquid for priming are introduced into the inside. The end cap 500 may be configured to allow air to flow out and prevent the priming liquid from leaking out.

The end cap 500 includes a vent filter 510 that blocks the passage of the liquid for priming but allows passage of gas. The vent filter 510 includes a hydrophobic filter. The end cap 500 may include a sponge 520 disposed on an upstream side of the vent filter 510 . The end cap 500 includes an end cap casing 530 accommodating the vent filter 510 therein. The end cap casing 530 forms a vent hole 530a through which gas passes. The end cap 500 includes an end cap coupling portion 540 configured to be coupled to the downstream connection portion 341a of the liquid delivery pipe device 340 . Arrow E1 in FIG. 1 shows coupling and separation directions of the end cap coupling portion 540 with respect to the downstream connection portion 341a.

When the end cap 500 is filled with the liquid for priming, the end cap 500 may be separated from the drug delivery pipe device 340, and the drug delivery pipe device 340 and the patient connection units 600 and 600' may be connected.

The patient connection units 600 and 600' may include an injection needle 610 or a catheter. The patient connection units 600 and 600' include components inserted into the patient's body, such as the injection needle 610.

The patient connection units 600 and 600' may include 'intake parts including components inserted into the patient's body, such as the injection needle 610', and 'remaining parts'. The lead-in part and the remaining parts may be detachably coupled to each other. In this case, in a state where the inlet part is connected to the patient but separated from the rest of the parts, the user can combine the rest of the parts with the drug delivery pipe device 340 and then couple the inlet part and the rest of the parts to each other. In this case, the liquid passing through the liquid medicine transfer pipe device 340 may be introduced into the patient's body through sequentially passing through the remaining parts and the inlet part.

The patient connection units 600 and 600' include an injection support 620 that supports an injection needle 610. The patient connection units 600 and 600' include a unit coupling portion 630 configured to be coupled with the downstream connection portion 341a of the drug delivery tube device 340. Arrow E2 in FIG. 1 shows the coupling and separation directions for the downstream connection portion 341a of the unit coupling portion 630 .

For example, the patient connection unit 600 may be configured by sequentially connecting an injection needle 610, an injection support 620, and a unit coupler 630.

As another example, the patient connection unit 600' further includes a patient connection pipe fixing part 650' connected to a downstream side of the unit coupling part 630. The patient connection unit 600' further includes a patient connection tube 640' connecting the patient connection tube fixing unit 650' and the injection support unit 620. The patient connector 640' may be formed of a flexible material. The patient connection unit 600′ may be configured by sequentially connecting the injection needle 610, the injection support unit 620, the patient connector 640′, the patient connector fixing unit 650′, and the unit coupling unit 630.

The chemical liquid flow line 320 is configured to guide the flow of the liquid for priming. An upstream end of the chemical liquid flow line 320 is connected to the inlet 110a of the chamber 110 . For example, the liquid medicine flow line 320 may be a flexible tube. In the chemical solution injection step according to an embodiment, the plunger 120 is moved in the pressurizing direction with reference to arrow F, so that the chemical solution filled into the chamber 110 flows through the chemical solution flow line 320, the air filter 330, and the chemical solution transfer pipe device 340 in sequence.

The air filter 330 may include a filter casing 331 connected to the liquid chemical flow line 320 and a filter 332 disposed within the filter casing 331 . The filter 332 of the air filter 330 may filter air bubbles.

The chemical liquid transfer pipe device 340 may include a transfer tube casing 341 connected to the air filter 330 and a chemical liquid transfer tube 342 disposed within the transfer tube casing 341 . The chemical solution transfer pipe 342 may have a capillary flow path through which the chemical solution flows. The chemical solution transfer pipe 342 may have a function of maintaining a constant flow rate per hour of the chemical solution flowing along the chemical solution flow line 320 .

2 is a cross-sectional view of the liquid chemical pumping device 100 according to the first embodiment. The chemical liquid pumping device 100 will be described in detail with reference to FIG. 2 as follows.

The plunger 120 includes a pressure surface 121 configured to pressurize the chemical liquid in the inner space 110s. The pressing surface 121 defines one side of the inner space 110s. The plunger 120 is disposed inside the chamber 110s so that the internal space 110s has a predetermined volume, and the chemical liquid pumping device 100 is provided so that the predetermined volume is not filled with the chemical liquid. The chemical liquid can be filled into the internal space 110s by a user. Before the chemical liquid is filled in the inner space 110s of the chemical liquid pumping device 100, sterilized air may be filled.

A closed space 110t positioned between the plunger 120 and the pressure operation unit 130 may be formed in the chamber 110 . The pressurization operation unit 130 may be configured to pressurize the chemical solution by the pressure of the gas generated therein through gas activation. Pressure is generated in the closed space 110t on the opposite side of the inner space 110s with respect to the plunger 120 by the pressurization operation unit 130 and the pressure is kept constant, thereby pressurizing the plunger 120 in the pressurizing direction and injecting the drug into the patient.

In one embodiment, the pressure operation unit 130 may include a liquid material (for example, citric acid) stored in the accommodating space 110u, and a solid material 133 (for example, sodium carbonate) stored separately from the liquid material by a partition before the operation of the pressure operation unit 130. The pressing operation unit 130 may include a pressing unit 131 configured to be pressable by a user. The pressure operation unit 130 may include an air passage filter 135 that passes gas generated in the accommodating space 110u to move to the closed space 110t but does not pass liquid therethrough. The pressure operation unit 130 may include a pressure control valve 137 that opens when the pressure in the closed space 110t exceeds a predetermined pressure, and connects the closed space 110t with an external space. The pressure control valve 137 may maintain a closed state by the elastic force of the spring 138 when the pressure in the closed space 110t does not exceed the preset pressure.

In one embodiment, when an external force is applied to the pressing part 131, the barrier rib is separated and the solid material 133 is introduced into the accommodation space 110u and reacts with the liquid material to generate gas (eg, carbon dioxide). Gas generated in the accommodating space 110u passes through the air filter 135 and flows into the closed space 110t, and as the pressure in the closed space 110t increases, the plunger 120 may move in the pressing direction.

The chemical liquid pumping device 100 may include a lubricant L applied to the inner surface of the chamber 110 in which the plunger 120 moves and slides. The lubricant (L) may be applied to the inner surface of the sliding chamber 110 while the plunger 120 moves. The lubricant (L) may be applied to the inner surface of the chamber 110 defining the inner space (110s) not filled with the chemical solution. For example, the lubricant L may be silicone oil or the like. The lubricant L is applied and cured on the inner surface of the chamber 110 to maintain a constant resistance value when the plunger 120 slides along the inner surface of the chamber 110 in the pressing direction, thereby preventing or reducing the occurrence of factors that change the flow rate of the chemical solution. During the manufacturing process of the chemical liquid pumping device 100, the plunger 120 is disposed inside the chamber 110 in such a way that the plunger 120 does not slide on the lubricant L applied to the inner surface, thereby minimizing damage or deformation of the applied lubricant L during manufacturing and when the user fills the chemical liquid.

An inlet 110a connected to the inner space 110s is formed in the chamber 110 . The chemical liquid flow line 320 has a chemical liquid flow passage 320p connected to the inlet 110a.

In the chamber 110, an inlet 110b connected to the inner space 110s is formed. The chemical solution may be filled into the inner space 110s through the inlet 110b. In the first to third embodiments, the inlet 110b is different from the inlet 110a, but as in the fourth embodiment described later, the inlet 110b and the inlet 110a may be the same.

The chamber 110 includes an inlet forming portion 115 forming an inlet 110b. The inlet forming part 115 may include a first part 115a fixed to one side of the chamber 110 and a second part 115b fixed to the first part 115a. The inlet 110b may be formed through the first part 115a and the second part 115b.

The chemical liquid pumping device 100 may include a one-way valve 116 disposed at the inlet 110b. The one-way valve 116 performs the function of a one-way valve. The one-way valve 116 prevents a reverse flow of the chemical liquid from the inlet port 110b to the outside of the inner space 110s. The one-way valve 116 allows the flow (inflow) of the chemical liquid moving from the outside to the inner space 110s, but blocks the flow (outflow flow) of the chemical liquid moving from the inner space 110s to the outside. The one-way valve 116 may include a protrusion (not shown) protruding in the direction of the inflow, and a hole (not shown) may be formed at a protruding end of the protrusion. The opening and closing of the hole of the one-way valve 116 depends on the flow direction of the chemical solution in the inlet 110b. The hole of the one-way valve 116 is opened when the chemical liquid in the inlet 110b flows in the direction of the inlet flow, and the hole of the one-way valve 116 is closed when there is no flow of the chemical liquid in the inlet 110b or the chemical liquid is about to flow in the outflow direction. The one-way valve 116 may include a flange portion (not shown) seated in the first portion 115a and the second portion 115b. The one-way valve 116 may be formed of a flexible material.

The chemical liquid pumping device 100 may include a pressure valve 117 that changes whether the inlet 110b is opened or closed. For example, the pressure valve 117 may be a swabable valve. The second part 115b may support the pressure valve 117 . The pressure valve 117 may include a surface forming a hole 117h that is opened when pressed from the outside. When the tip of the syringe is pressed from the outside to the surface forming the hole 117h of the pressure valve 117, the surface may be bent and the hole 117h may be opened. The pressure valve 117 may be formed of a flexible material.

A vent hole 110c may be formed in the chamber 110 . The vent hole 110c is a separate passage different from the inlet 110a and the inlet 110b.

The chemical liquid pumping device 100 may include a hydrophobic filter 118 configured to allow air discharged from the inner space 110s through the vent hole 110c to pass through and block the passage of liquid. When a user fills the inner space 110s with a medicinal solution, air in the inner space 110s may pass through the hydrophobic filter 118 and be discharged to the outside through the vent hole 110c. Through this, since the user can fill the drug solution in a state in which the inlet 110a is blocked, the drug solution injection can be prepared more hygienically.

The hydrophobic filter 118 may be located on the opposite side of the plunger 120 based on the inner space 110s. For example, the plunger 120 is located on the lower side and the hydrophobic filter 9118 is located on the upper side with respect to the inner space 110s. The chamber 110 may be configured such that the inner space 110s protrudes toward the opposite side (ie, the opposite side of the plunger with respect to the inner space). The hydrophobic filter 118 may be located in the protruding portion of the inner space 110s. Through this, the air in the inner space 110s can be efficiently guided to the hydrophobic filter 118 and discharged to the outside.

Although not shown, the chemical liquid pumping device 100 may include a hook (not shown) configured to be hung on the outside. The hanging part may be coupled to a predetermined position of the chemical solution pumping device 100 so that the hydrophobic filter 118 is disposed on the upper side of the inner space 110s by gravity when hanging outside. For example, the hook part may include a hook and a connector.

3 is a cross-sectional view of the liquid chemical pumping device 100' according to the second embodiment. Referring to FIG. 3 , the chemical liquid pumping apparatus 100 ′ according to the second embodiment will be described with a focus on differences from the chemical liquid pumping apparatus 100 according to the first embodiment of FIG. 2 .

In the chemical liquid pumping device 100', a vent hole 110c is formed at one side of the inlet 110a. The chamber 110 of the chemical liquid pumping device 100' may be configured such that the inner space 110s protrudes toward the opposite side (ie, the opposite side of the plunger based on the inner space). An inlet 110a and a hydrophobic filter 118 may be positioned in the protruding portion. Through this, the air in the inner space 110s can be efficiently guided to the hydrophobic filter 118 and discharged to the outside.

4 is a cross-sectional view of a liquid chemical pumping device 100'' according to a third embodiment. Referring to FIG. 4 , the chemical liquid pumping apparatus 100 ″ according to the third embodiment will be described with a focus on differences from the chemical liquid pumping apparatus 100 according to the first embodiment of FIG. 2 .

The chamber 110 of the chemical liquid pumping device 100'' does not include the hydrophobic filter 118. In a state in which the inlet 110a is not connected to the liquid medicine flow line 320, the user fills the drug into the inner space 110s through the inlet 110b and the air inside is discharged to the outside through the inlet 110a. The user may connect the injection port 110a and the liquid medicine flow line 320 after completing drug filling. For example, a screw 119 may be provided to couple the chamber 110 and the chemical liquid flow line 320 to each other.

5 is a cross-sectional view of a liquid chemical pumping device 100''' according to a fourth embodiment. Referring to FIG. 5 , the chemical liquid pumping apparatus 100''' according to the fourth embodiment will be described with a focus on differences from the chemical liquid pumping apparatus 100'' according to the third embodiment of FIG. 4 as follows.

The inlet 110a and the inlet 110b of the chemical liquid pumping device 100''' are identical to each other. The chemical liquid pumping device 100''' does not include the hydrophobic filter 118. The chemical liquid pumping device 100''' does not include the one-way valve 116 and the pressure valve 117. In a state in which the inlet 110a is not connected to the drug liquid flow line 320, the user fills the drug into the inner space 110s through the inlet 110b, which is the inlet 110a, and the air inside the inlet 110b. It can be discharged to the outside. The user may connect the injection port 110a and the liquid medicine flow line 320 after completing drug filling. For example, a screw 119 may be provided to couple the chamber 110 and the chemical liquid flow line 320 to each other.

6 is a flowchart showing a method for preparing a chemical solution injection according to an embodiment of the present disclosure. The preparation method for drug injection includes a chamber 110 in which an inner space 100s is formed and different injection ports 110a and inlets 110b connected to the inner space 100s are formed. It may be a method using a device for injection. Hereinafter, the preparation method for chemical injection will be described in detail based on the chemical solution injection device 1 including the chemical solution pumping device 100 according to the first embodiment with reference to FIGS.

FIG. 7 is a cross-sectional view of the chemical liquid pumping device 100 showing a state in which the chemical liquid M is being filled into the chamber 110 in the chamber filling step (S10) of the preparation method of FIG. 6 . Referring to FIGS. 6 and 7 , the preparation method may include a chamber filling step ( S10 ) of filling the chemical solution M into the inner space 110s of the chamber 110 . In the chamber filling step (S10), the chemical solution M is introduced into the inner space 110s of the chamber 110 through the inlet 110b (see arrow F1), and the air in the inner space 110s passes through the hydrophobic filter 118 and may be discharged to the outside through the vent hole 110c (see arrow A1). Depending on the embodiment, the chamber filling step (S10) may be performed by a user before proceeding with drug injection in a hospital or the like, but the chamber filling step (S10) may be performed by a user who manufactures the pre-filled chemical pumping device 100 in the process of manufacturing the pre-filled drug pumping device.

FIG. 8 is a cross-sectional view of the chemical solution pumping device 100 showing how the chemical solution M is completely filled into the chamber 110 in the chamber filling step (S10) of the preparation method of FIG. 6 . Referring to FIG. 8 , when the chamber filling step (S10) is completed, the inner space 110s of the chamber 110 is filled with the chemical liquid M.

FIG. 9 is a cross-sectional view of the chemical solution pumping device 100 showing how an additional chemical solution M is filled into the chamber 110 in the additional chemical solution filling step (S20) of the preparation method of FIG. 6 . 6 and 9, in the preparation method, in a state in which the internal space 110s is filled with the chemical liquid M, the additional chemical liquid M is introduced into the internal space 110s through the inlet 110b, and the plunger 120 moves so that the volume of the internal space 110s increases (see arrow M1), thereby generating pressure for the plunger 120 to push the chemical liquid M. (S20) is included. In the additional chemical solution filling step (S20), the additional chemical solution M may flow into the inner space 110s through the inlet 110b (see arrow F2).

Here, the pressure at which the plunger 120 pushes the chemical liquid M may be a pressure that increases in the closed space 110t. In the additional chemical filling step (S20), the pressure may be generated by compressing the closed space 110t on the opposite side of the inner space 110s with respect to the plunger 120. The plunger 120 may move in a direction M1 opposite to the pressing direction by the chemical liquid M added to the inner space 110s, thereby compressing the closed space 110t.

The amount of the chemical solution M filled in the internal space 110s before the additional chemical solution filling step (S10) (refer to the amount of the chemical solution shown in FIG. 8) is greater than the amount of the chemical solution M filled in the additional chemical solution filling step (S20). The amount of the chemical solution M filled in the additional chemical solution filling step (S20) may be the amount of the chemical solution for filling the flow path of the chemical solution flow part 300 such as the chemical solution flow channel 320p (ie, the amount of the chemical solution required for priming).

FIG. 10 is a cross-sectional view of the chemical liquid pumping device 100 showing how priming is performed by the chemical liquid M in the priming step (S30) of the preparation method of FIG. 6 . 6 and 10, the preparation method includes a priming step (S30) of filling the chemical fluid flow passage 320p by moving the chemical fluid M due to the pressure generated in the additional chemical fluid filling step S20 by which the plunger 120 pushes the chemical fluid M. The priming step (S30) may be started after the additional chemical injection step (S20) is first started and then finished.

Although the technical spirit of the present disclosure has been described by the examples shown in some of the embodiments and the accompanying drawings, it is to be understood that various substitutions, modifications, and changes may be made without departing from the technical spirit and scope of the present disclosure that can be understood by those skilled in the art to which the present disclosure belongs. Moreover, such substitutions, modifications and alterations are intended to fall within the scope of the appended claims.

Reference Numerals 1: chemical injection device, L: lubricant, M: chemical liquid, 100, 100', 100'', 100''': chemical liquid pumping device, 110: chamber, 110s: inner space, 110t: sealed space, 110a: inlet, 110b: inlet, 116: one-way valve, 110c: vent hole, 118: hydrophobic filter, 1 Reference Numerals 20: plunger, 130: pressure operation unit, 300: chemical liquid flow unit, 320: chemical liquid flow line, 330: air filter, 340: chemical liquid transfer pipe device, 500: end cap, 600, 600': patient connection unit

Claims (13)

A chamber having an inner space filled with air but not filled with chemical liquid, an inlet connected to the inner space, an inlet connected to the inner space and different from the inlet, and a vent hole that is a separate passage from the inlet;
a plunger disposed inside the chamber so that the internal space filled with air and not filled with the chemical liquid has a predetermined volume;
a lubricant applied to an inner surface of the chamber in which the plunger is movable and slidable;
a one-way valve disposed at the inlet and configured to allow a flow of the chemical liquid moving from the outside into the inner space and block the flow of the chemical liquid moving from the inner space to the outside; and
And a hydrophobic filter configured to allow the passage of air discharged from the inner space to the outside through the vent hole and prevent the passage of liquid.
liquid pumping device. According to claim 1,
The hydrophobic filter is located on the opposite side of the plunger based on the inner space,
liquid pumping device. According to claim 2,
The chamber is configured such that the inner space has a shape protruding in a direction opposite to the plunger based on the inner space,
The hydrophobic filter is located in the protruding part of the inner space,
liquid pumping device. According to claim 1,
And a pressing operation unit configured to press the plunger so that the volume of the inner space is reduced.
liquid pumping device. According to claim 4,
The pressure operation unit is configured to pressurize the plunger by the pressure of the gas generated therein,
liquid pumping device. The chemical liquid pumping device according to claim 1; and a chemical solution injection preparation method using a chemical solution injection device including a chemical solution flow line having a drug solution flow path connected to the inlet,
a chamber filling step of filling an air-filled inner space of the chamber with the chemical liquid, and discharging the air in the inner space through the hydrophobic filter to the outside through the vent hole;
In a state in which the internal space is filled with the chemical liquid, an additional chemical liquid is introduced into the internal space through the inlet and the plunger moves to increase the volume of the internal space, thereby generating pressure for pushing the chemical liquid by the plunger; and
And a priming step of moving the chemical liquid by the pressure to fill the chemical liquid flow passage.
How to prepare for drug injection. According to claim 6,
In the additional chemical filling step, the pressure is generated by compressing the closed space on the opposite side of the inner space based on the plunger.
How to prepare for drug injection. According to claim 6,
The amount of the chemical solution filled in the inner space before the additional chemical solution filling step is greater than the amount of the chemical solution filled in the additional chemical solution filling step;
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