KR102548951B1 - Use of natural products to induce sleep and improve sleep quality - Google Patents

Abstract

The present invention relates to a composition for inducing sleep or improving sleep disorder comprising a natural product-derived ingredient as an active ingredient, and more specifically, since it contains a natural product-derived ingredient as an active ingredient, it induces excellent sleep without causing side effects of synthetic drugs. Or it relates to a composition for inducing sleep or improving sleep disorders having a sleep disorder improving effect.
According to the present invention, the composition for inducing sleep or improving sleep disorders comprising the natural product-derived ingredient of the present invention as an active ingredient has an excellent sleep inducing effect by reducing sleep latency and increasing sleep duration, Since it has the effect of improving the quality of sleep, it can be usefully used for inducing sleep or improving sleep disorders.

Description

Use of natural products to induce sleep and improve sleep quality}

The present invention relates to a composition for inducing sleep or improving sleep disorder comprising a natural product-derived ingredient as an active ingredient, and more specifically, since it contains a natural product-derived ingredient as an active ingredient, it induces excellent sleep without causing side effects of synthetic drugs. Or it relates to a composition for inducing sleep or improving sleep disorders having a sleep disorder improving effect.

Sleep disorder is one of the common problems of modern people. Sleep disorder refers to a condition in which a person does not get sound sleep, is unable to maintain arousal during the day despite having enough sleep, or has difficulty falling asleep or waking up due to disturbed sleep rhythm. Mental problems are also a major cause, and it occurs due to excessive stress, anxiety, tension, and fear. Sleep disturbance is a very common condition that has experienced or suffers from more than 20% of the population. Sleep disorders can cause various personal and social problems, and cause learning disabilities, reduced performance, traffic accidents, safety accidents, emotional disorders, social adjustment disorders, dissatisfaction in marriage, and industrial accidents. In addition, if sleep disorders are not properly treated, existing medical, neurological, and psychiatric diseases may worsen or recovery may be delayed, and serious diseases such as myocardial infarction and stroke may result.

As treatment drugs, benzodiazepine drugs and serotonin agonists are used. Many drugs, including benzodiazepines, have pharmacological effects by binding to GABAA receptors, and when drugs or adjuvants bind to the benzodiazepine site, the GABAA receptor affinity for GABA is enhanced and the influx of chloride ions into cells is increased. It relieves anxiety, improves convulsions, sedates, and induces and improves sleep. GABAA receptors are pentameric proteins that form membrane ion channels, and are closely related to the regulation of sedation, sleep, anxiety, muscle tension, convulsions, memory loss, etc., through which GABA (gamma-aminobutyric acid) acts. When these drugs are used for a long time, they are accompanied by side effects such as tolerance and dependence, and also cause serious problems such as muscle relaxation and forgetfulness.

Due to the side effects of the above drugs, the need for natural sleep aids is increasing as a means to replace them in the case of long-term users and restrictive users of sleeping pills. In developed countries, the market for sleep-promoting health functional foods that can replace or reduce sleeping pills is expanding, and the desire to improve the quality of sleep is increasing as the LOHAS trend spreads and interest in sleep increases. Demand for sleep-enhancing compositions is expected to further expand.

As such, modern people's interest in sleep aids, etc., which are excellent in inducing sleep or improving sleep disorders without causing side effects of synthetic drugs, is increasing. The invention was completed.

An object of the present invention is to provide a food composition for inducing sleep or improving sleep disorders.

Another object of the present invention is to provide a health functional food composition for inducing sleep or improving sleep disorders.

Another object of the present invention is to provide a pharmaceutical composition for preventing or treating sleep disorders.

In order to solve the above problems, the present invention provides a food composition for inducing sleep or improving sleep disorders.

In addition, it provides a health functional food composition for inducing sleep or improving sleep disorders in order to solve the above problems.

It also provides a pharmaceutical composition for preventing or treating sleep disorders in order to solve the above problems.

According to the present invention, the composition for inducing sleep or improving sleep disorders comprising the natural product-derived ingredient of the present invention as an active ingredient has an excellent sleep inducing effect by reducing sleep latency and increasing sleep duration, The effect of improving the quality of

1 is a diagram showing Pittsburgh sleep quality index questions.
Figure 2 shows the evaluation (primary evaluation) of the quality of sleep for one month before ingestion of the composition for inducing sleep or improving sleep disorder containing a natural product-derived component of the present invention as an active ingredient.
Figure 3 evaluates the results after ingesting the composition for inducing sleep or improving sleep disorders containing the natural product-derived ingredient of the present invention as an active ingredient for one week after the first evaluation of the Pittsburgh sleep quality index (second evaluation) This is the diagram shown by
Figure 4 evaluates the quality of sleep for a week after completing the intake of the composition for inducing sleep or improving sleep disorders containing the natural product-derived component of the present invention as an active ingredient after the second evaluation of the Pittsburgh sleep quality index is a result

The language used in this specification and claims should not be construed as being limited to the usual or dictionary meaning, and the inventor can properly define the concept of the term in order to explain his/her invention in the best way. Based on the principle, it must be interpreted as meaning and concept corresponding to the technical idea of the invention. Therefore, since the configurations of the embodiments described in this specification are only one of the most preferred embodiments of the present invention and do not represent all of the technical spirit of the present invention, various equivalents and equivalents that can replace them at the time of this application It should be understood that variations may exist.

The terms used in the present invention have been selected from general terms that are currently widely used as much as possible while considering the functions in the present invention, but these may vary depending on the intention of a person skilled in the art or precedent, the emergence of new technologies, and the like. In addition, in a specific case, there is also a term arbitrarily selected by the applicant, and in this case, the meaning will be described in detail in the description of the invention. Therefore, the term used in the present invention should be defined based on the meaning of the term and the overall content of the present invention, not simply the name of the term.

When it is said that a certain part "includes" a certain component throughout the specification, it means that it may further include other components without excluding other components unless otherwise stated.

It is only described in detail by exemplifying specific embodiments, and since the present invention can be variously changed and can have various forms, the present invention is not limited to the specific embodiments illustrated. It should be understood that the present invention includes all modifications, equivalents and substitutes included in the spirit and scope of the present invention.

The present invention provides, for example, a food composition or a health functional food composition for inducing sleep or improving sleep disorders.

The food composition or functional health food composition for inducing sleep or improving sleep disorder is at least one selected from the group consisting of natural products, such as ginseng, wheat, lotus meat, jujube, jujube seed, gardenia, bokryeong, red ginseng, and Ecklonia cava extract powder, which are natural products as an active ingredient. may be included as an active ingredient.

More specifically, the food composition or health functional food composition for inducing sleep or improving sleep disorders includes 15 to 25 parts by weight of ginseng stem and 10 to 20 parts by weight of wheat, based on 100 parts by weight of the total. Lotus meat 10 to 20 parts by weight, jujube 10 to 20 parts by weight, jujube seeds 5 to 15 parts by weight, gardenia 5 to 15 parts by weight, bokryeong 5 to 15 parts by weight. It may include 0.5 to 5 parts by weight of red ginseng and 1 to 10 parts by weight of Ecklonia cava extract powder, more preferably 18 to 22 parts by weight of ginseng stem and 12 to 16 parts by weight of wheat based on 100 parts by weight of the total. Lotus meat 12 to 16 parts by weight, jujube 12 to 16 parts by weight, jujube seeds 6 to 10 parts by weight, gardenia 6 to 10 parts by weight, bokryeong 6 to 10 parts by weight. It may include 1 to 4 parts by weight of red ginseng and 5 to 7 parts by weight of Ecklonia cava extract powder, and when the content of each of the raw materials is less than or exceeds the set range, it may be difficult to expect a sleep effect.

As used herein, the term "extract" refers to an extract obtained from the natural product, and may include an extract, a diluent or concentrate of the extract, a dried product obtained by drying the extract, or a crude or purified product thereof, or a fraction thereof.

In this specification, the term "sleep induction" may mean a decrease in sleeping time or an increase in sleep duration.

As used herein, the term "sleep disorder" refers to all diseases related to sleep, and refers to symptoms of sleep disturbance due to various factors. Specifically, sleep disorders include symptoms that interfere with daily life, such as feeling chronic fatigue due to not getting enough or sound sleep, daytime drowsiness, or feeling a headache. Including all symptoms that prevent taking Here, sound sleep means a state of deep sleep without tossing and turning for 4 to 6 hours, and having a deep sleep to the extent that you do not remember dreams or how much you slept.

The sleep disorder is preferably somnolence disorder, sleep disorder, middle awakening, early awakening, insomnia, nightmare, sleepwalking, narcolepsy, abnormal behavior during sleep, hypersomnia, sleep seizure, breathing related sleep disorder, apnea, circadian It may be any one or more selected from the group consisting of circadian rhythm sleep disorders, parasomnia, restless legs syndrome, and periodic limb movement syndrome, but is not limited thereto.

As used herein, the term "improvement" may refer to any activity that at least reduces a parameter associated with alleviation or treatment of a condition, for example, the severity of a symptom.

In this specification, "composition" means a state that can be directly eaten through a certain degree of processing using a natural product or processed product containing one or more nutrients, and is a common meaning, and its type Is not particularly limited, and includes, but is not limited to, the above compositions (eg, fruits, vegetable compositions, soy milk, fermented compositions, ice creams, etc.), vitamin complexes, alcohol compositions, alcoholic beverages and other liquids. The composition may be prepared as a food additive by a conventional manufacturing method.

In this specification, 'food' means a natural product or processed product containing one or more nutrients, preferably means that it is in a state that can be eaten directly through a certain degree of processing process, and usually means And, the type is not particularly limited, and the food composition may include all foods, food additives, health functional foods and beverages.

Foods to which the composition of the present invention can be added include, for example, various foods, beverages, gum, candy, tea, vitamin complexes, and functional foods. In addition, in the present invention, the food includes special nutritious food (eg, formula milk, infant food, baby food, etc.), processed meat product, fish meat product, tofu, jelly, noodles (eg, ramen, noodles, etc.), health supplement food, seasoning food ( For example, soy sauce, soybean paste, red pepper paste, mixed soybean paste, etc.), sauces, confectionery (eg, snacks), dairy products (eg, fermented milk, cheese, etc.), other processed foods, kimchi, pickled foods (various types of kimchi, pickles, etc.), beverages (eg, fruit and vegetable beverages, soy milk, fermented beverages, ice cream, etc.), natural seasonings (eg, ramen soup, etc.), vitamin complexes, alcoholic beverages, alcoholic beverages, and other health supplements, but are not limited thereto. The food, beverage or food additive may be prepared by a conventional manufacturing method.

As another example, the present invention provides a pharmaceutical composition for preventing or treating sleep disorders.

At this time, the active ingredient of the pharmaceutical composition for preventing or treating sleep disorders, and its effects are as described above.

As used herein, the term "pharmaceutical composition" can refer to a molecule or compound that imparts some beneficial effect upon administration to a subject. Beneficial effects may include enabling diagnostic determination; amelioration of a disease, symptom, disorder or condition; reducing or preventing the occurrence of a disease, condition, disorder or condition; and responding to a disease, symptom, disorder or condition in general.

In this specification, the term "composition" can be administered parenterally during clinical administration and can be used in the form of a general pharmaceutical preparation. Parenteral administration may refer to administration through an administration route other than oral, such as rectal, intravenous, peritoneal, intramuscular, arterial, transdermal, nasal, inhalation, ocular and subcutaneous administration. When the pharmaceutical composition of the present invention is used as a medicine, it may additionally contain one or more active ingredients exhibiting the same or similar functions.

Types of pharmaceutically active ingredients capable of delivering the active ingredient into the subject include anticancer agents, contrast agents (dye), hormones, anti-hormonal agents, vitamins, calcium agents, mineral preparations, saccharide preparations, organic acid preparations, protein amino acid preparations, detoxifying agents, and enzymes. Preparations, metabolic preparations, diabetes concomitant medicines, tissue regeneration medicines, chlorophyll preparations, pigment preparations, tumor medicines, tumor treatment agents, radiopharmaceuticals, tissue cell diagnostic agents, tissue cell therapy agents, antibiotics preparations, antiviral agents, complex antibiotics preparations, chemicals Therapeutic agents, vaccines, toxins, toxoids, antitoxins, leptospira serum, blood products, biological agents, analgesics, immunogenic molecules, antihistamines, allergy medications, non-specific immunogenic agents, anesthetics, stimulants, psychoactive agents, small molecule compounds, nucleic acids, It may include aptamers, antisense nucleic acids, oligonucleotides, peptides, siRNAs, and micro RNAs.

The pharmaceutical composition may be prepared by further including one or more pharmaceutically acceptable carriers. A pharmaceutically acceptable carrier may be a mixture of saline, sterile water, Ringer's solution, buffered saline, dextrose solution, maltodextrin solution, glycerol, ethanol, and one or more of these components, and, if necessary, antioxidants and buffers. , bacteriostatic agents and other conventional additives may be added. In addition, diluents, dispersants, surfactants, binders, and lubricants may be additionally added to prepare formulations for injections such as aqueous solutions, suspensions, and emulsions, pills, capsules, granules, or tablets. Furthermore, it can be preferably formulated according to each disease or component by an appropriate method in the art.

When formulating the pharmaceutical composition, it is prepared using diluents or excipients such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants. Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solvents, suspensions, emulsions, freeze-dried formulations, and suppositories. Propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate may be used as non-aqueous solvents and suspending agents. As a base for the suppository, Witepsol, Macrogol, Tween 61, cacao butter, liurine fat, glycerogeratin and the like may be used.

The pharmaceutical composition may include carbohydrates such as glucose, sucrose or dextran, antioxidants such as ascorbic acid or glutathione, chelating agents, and small molecules in order to increase stability or absorption. Proteins or other Stabilizers can be used as pharmaceuticals.

According to one embodiment of the present invention, when ingesting the composition of the present invention, the sleep induction time was 6.7 minutes on average and the sleep time was 5.8 hours on average, confirming the effect of reducing sleep latency and increasing sleep time (Experimental Example 1 ).

According to one embodiment of the present invention, as a result of evaluating Pittsburgh sleep quality for a period of one month before intake of the composition of the present invention, one week after intake, and one week after stopping intake, the results were 12.29 points, 6.25 points, and 7 points, respectively. Obtained, the evaluation index before and after intake of the composition of the present invention showed a difference of about 2 times, and it was confirmed that the above results showed an excellent effect on improving the quality of sleep (Experimental Example 2).

In addition, sleep disorder patients, for example, insomnia, sleep disorder, middle awakening, early awakening, insomnia, nightmare, sleepwalking, narcolepsy, abnormal behavior during sleep, hypersomnia, sleep seizure, breathing related sleep disorder, apnea , circadian rhythm sleep disorders, parasomnia, restless legs syndrome, and periodic limb movement syndrome, patients with one or more diseases are characterized by significantly poor sleep quality, When ingesting the composition of the present invention, it is evident that there is a significant effect of treating sleep disorders by improving the sleep quality of patients with the above diseases, and also, the sleeping time is long or the sleeping time is reduced, so the quality of sleep is lowered Accordingly, when the possibility of developing the above diseases is high, it is obvious that the composition of the present invention is ingested to reduce the sleeping time while increasing the sleeping time to significantly improve the quality of sleep, thereby having a remarkable effect of preventing the above diseases. .

Hereinafter, the present invention will be described in detail by examples.

On the other hand, the claims of the present invention are not limited to the following examples, and should be construed as including all subjects belonging to the same category.

Example 1. Preparation of a composition for inducing sleep or improving sleep disorder

1-1. Preparation of the concentrated mixture before blending

Each component for preparing the following mixture was purchased commercially.

Oak tree (domestic) 70 kg (mixing ratio 20.649% (w/w)), wheat (domestic) 50 kg (mixing ratio 14.749% (w/w)), lotus meat (Vietnam) 50 kg (14.749% (w/w)) )), jujube (Korea) 50 kg (mixing ratio 14.749% (w/w)), jujube seed (Myanmar) 30 kg (mixing ratio 8.850% (w/w)), gardenia (made in China) 30 kg (mixing ratio) 8.850% (w/w), Bokryeong (made in China) 30 kg (mixing ratio 8.850% (w/w)), red ginseng (domestic) 8 kg (mixing ratio 2.360% (w/w)), and Ecklonia cava extract powder (domestic product) ) A concentrated mixture was prepared by uniformly mixing 21 kg (6.195% (w/w)) of Ecklonia cava extract (Table 1).

In addition, for mixing, the mixing tank (Daegu Techno Bio Center) and pipes were pre-sterilized with hot water of 95 ° C. or higher for 5 minutes or more.

Blending amount (kg) Weight % (w/w) Gasiogapi 70 20.649 wheat 50 14.749 Yeonjayuk 50 14.749 jujube 50 14.749 Jujube Seed 30 8.850 Gardenia 30 8.850 Bokryeong 30 8.850 red ginseng 8 2.360 Ecklonia Extract Powder 21 6.195 total 339 100.000

1-2. Preparation of tart cherry juice powder before blending

Tart cherry juice powder is Tart fruit juice powder (made in Poland) 119 kg (mixing ratio 70% (w/w)), fish collagen (made in Vietnam) 12.75 kg (mixing ratio 7.5% (w/w)), beetroot concentrate powder (Made in Poland) 9.35 kg (mixing ratio 5.5% (w/w)), vitamin C (made in China) 13.6 kg (mixing ratio 8% (w/w)), natural cherry flavor (made in Korea) 5.1 kg (mixing ratio 3%) (w / w)) and Enzyme choristevia (domestic) 10.2 kg (mixing ratio 6% (w / w)) was prepared by uniformly mixing (Table 2).

Blending amount (kg) Weight % (w/w) Tart Fruit Juice Powder 119 70.00 fish collagen 12.75 7.50 Beet Root Concentrate Powder 9.35 5.50 vitamin C 13.6 8.00 natural cherry flavor 5.1 3.00 Enzymatically Treated Stevia 10.2 6.00 total 170 100.00

1-3. formulation process

4000 L of purified water was put into the mixing tank pre-sterilized in Example 1-1, 339 kg of the concentrated mixture prepared in Example 1-1 and 170 kg of the mixture prepared in Example 1-2 were added, and L-theanine (made in China) was added. ) 4 kg was added and stirred to prepare a formulation (beverage composition) of 4513 kg (Table 3).

Blending amount (kg) Weight % (w/w) Gasiogapi 70 1.551 wheat 50 1.108 Yeonjayuk 50 1.108 jujube 50 1.108 Jujube Seed 30 0.665 Gardenia 30 0.665 Bokryeong 30 0.665 red ginseng 8 0.177 Ecklonia Extract Powder 21 0.465 Tart Fruit Juice Powder 119 2.637 fish collagen 12.75 0.283 Beet Root Concentrate Powder 9.35 0.207 vitamin C 13.6 0.301 natural cherry flavor 5.1 0.113 Enzymatically Treated Stevia 10.2 0.226 L-theanine 4 0.089 Purified water 4000 88.632 total 4513 100.000

Example 2. Manufacture of Concentrated Mixtures Excluding Casiogapi Stem and Red Ginseng

A concentrated mixture was prepared in the same manner as in Example 1-1, but after excluding ginseng tree (spinus ginseng stem) and red ginseng, it was prepared by adding ginseng and red ginseng and additional wheat (wheat).

Example 3. Preparation of Concentrated Mixture Except Ecklonia and Gardenia

A concentrated mixture was prepared in the same manner as in Example 1-1, except for Ecklonia cava and gardenia, and then adding sub-maek (wheat) of the same mass as the Ecklonia cava and gardenia.

Example 4. Preparation of beverages containing blueberry juice powder

A formulation (beverage composition) was prepared in the same manner as in Example 1, but blueberry juice powder (origin: USA, manufacturer: Haechansol Food, Brix 67) was added instead of tart cherry juice powder in Example 1-2. The specific content ratio / composition ratio of the prepared formulation (beverage composition) is shown in Table 4.

Blending amount (kg) Weight % (w/w) Gasiogapi 70 1.551 wheat 50 1.108 Yeonjayuk 50 1.108 jujube 50 1.108 Jujube Seed 30 0.665 Gardenia 30 0.665 Bokryeong 30 0.665 red ginseng 8 0.177 Ecklonia Extract Powder 21 0.465 Blueberry Juice Powder 119 2.637 fish collagen 12.75 0.283 Beet Root Concentrate Powder 9.35 0.207 vitamin C 13.6 0.301 natural cherry flavor 5.1 0.113 Enzymatically Treated Stevia 10.2 0.226 L-theanine 4 0.089 Purified water 4000 88.632 total 4513 100.000

Experimental Example 1. Elevation time and sleep time increase effect confirmation of concentrated mixture

In order to confirm the efficacy of reducing the sleep latency and increasing the sleep duration of the concentrated mixture of the present invention, the experiment was conducted as follows.

Specifically, 10 male and female test subjects drank 100 mL of the concentrated mixture prepared by the methods of Examples 1-1, 2 and 3 daily for 14 days, and each sleep latency and sleep time (Sleep duration) was measured. The subjects of this experiment were selected as 10 men and women who did not have sleep disorders and did not complain of difficulty in sleeping. Tables 5 to 10 The effect on sleep induction of each test subject was measured before intake of the concentrated mixture, after intake before bedtime for a week, and after intake every day for a week and after intake was stopped for a week, for a total of three times.

Example 1-1 Sleep induction time according to intake test subject 1 day 2 days 3 days 4 days 5 days 6 days 7 days 8 days 9 days 10 days 11 days 12 days 13th 14 days average no. 1 4.6 3.9 4.3 4.4 4.6 4.2 4.4 4.3 3.9 4.3 3.8 4.4 4.2 3.3 4.2 No.2 6.7 6.7 7.5 6.6 6.7 5.7 5.6 6.4 5.6 5.6 6.2 5.7 5.7 5.4 6.2 number 3 9.1 8.9 8.3 5.9 7.2 6.9 6.3 6.3 6.5 5.7 4.7 4.6 4.7 4.9 6.4 4 times 8.6 8.7 8.3 8.1 7.8 8.5 6.2 6.5 5.7 4.6 5.5 4.2 4.1 3.6 6.5 number 5 10.3 10.4 9.8 9.8 9.5 10.2 7.9 8.2 7..4 6.3 7.2 5.9 5.8 5.3 8.1 number 6 11.3 11.4 10.3 10.3 10 10.7 8.4 9.1 7.9 7.5 8.1 7.2 7.3 6.8 9.0 number 7 8.3 8.4 7.3 7..3 6.5 7.7 5.4 6.1 4.9 4.5 5.1 4.2 4.3 3.8 6.0 number 8 8.9 8.7 7.9 7.9 7.6 8.3 6.2 6.7 5.5 5.1 5.7 4.8 4.9 4.4 6.6 number 9 9.5 9.6 8.5 8.5 8.2 8.9 6.6 6.5 6.1 5.7 5.7 5.4 5.5 4.7 7.1 No. 10 8.4 9.2 8.3 7.5 7.8 8.5 6.2 6.3 5.7 5.3 5.3 5.2 5.3 4.6 6.7 Overall average (min) 6.7

Example 2 Sleep induction time according to intake test subject 1 day 2 days 3 days 4 days 5 days 6 days 7 days 8 days 9 days 10 days 11 days 12 days 13th 14 days average no. 1 5.5 4.8 5.2 5.3 5.5 5.1 5.3 5.2 4.8 5.2 4.7 5.3 5.1 4.2 5.1 No.2 8.2 8.2 8.5 8.1 8.2 7.2 7.1 7.9 7.1 7.1 7.5 7.2 7.2 6.9 7.6 number 3 11.3 11.1 10.5 8.1 9.2 9.1 8.5 8.5 8.7 8.2 7.2 6.8 7.2 7.1 8.7 4 times 11.6 11.7 11.3 11.1 10.8 11.5 9.2 9.5 8.7 7.6 8.5 7.2 7.1 6.6 9.5 number 5 11.3 11.4 10.8 10.8 10.5 11.2 8.9 9.2 8.4 7.3 8.2 6.9 6.8 6.3 9.1 number 6 12.8 12.9 11.8 11.8 11.5 12.2 9.9 10.6 9.4 9 9.6 8.7 8.8 8.3 10.5 number 7 11.3 11.4 10.3 10.3 10 10.7 8.4 9.1 7.9 7.5 8.1 7.2 7.3 6.8 9.0 number 8 10.6 10.7 9.6 9.6 9.3 10 7.7 8.4 7.2 6.8 7.4 6.5 6.6 6.1 8.3 number 9 10.2 10.3 9.2 9.2 8.9 9.6 7.3 7.2 6.8 6.4 6.4 6.1 6.2 5.7 7.8 No. 10 8.3 9.1 8.2 7.4 7.7 8.4 6.1 6.2 5.6 5.2 5.2 4.9 5.2 4.5 6.6 Overall average (min) 8.2

Example 3 Sleep induction time according to intake test subject 1 day 2 days 3 days 4 days 5 days 6 days 7 days 8 days 9 days 10 days 11 days 12 days 13th 14 days average no. 1 10.1 9 9 9.0 10.1 9.7 9.9 9.8 9.4 9.8 9.3 9.9 9.7 9.8 9.7 No.2 15.5 15.5 15.8 15.4 15.5 14.5 14.4 15.2 14.4 14.4 14.8 14.5 14.5 14.2 14.9 number 3 19.6 19.4 18.8 16.4 17.5 17.4 16.8 16.8 17 16.5 15.5 15.1 15.5 15.4 17.0 4 times 18.6 18.7 18.3 18.1 17.8 18.5 16.2 16.5 15.7 14.6 15.5 14.2 14.1 13.6 16.5 number 5 19.5 19.6 19 19 18.7 19.4 17.1 17.4 16.6 15.5 16.4 15.1 15 14.5 17.3 number 6 20.6 20.7 196. 19.6. 19.3 20 17.7 18.4 17.2 16.8 17.4 16.5 16.6 16.1 18.3 number 7 19.1 19.2 18.1 18.1 17.8 18.5 16.2 16.9 15.7 15.3 15.9 15 15.1 14.6 16.8 number 8 19.8 19.9 18.8 18.8 18.5 19.2 16.9 17.6 16.4 16 16.6 157. 15.8 15.3 17.5 number 9 18.3 18.4 17.3 17.3 17 17.7 15.4 15.3 14.9 14.5 14.5 14.2 14.3 13.8 15.9 No. 10 14.9 15.7 14.8 14 14.3 15 12.7 12.8 12.2 11.8 11.8 11.5 11.8 11.1 13.2 Overall average (min) 15.7

Example 1-1 Sleep time according to intake test subject 1 day 2 days 3 days 4 days 5 days 6 days 7 days 8 days 9 days 10 days 11 days 12 days 13th 14 days average no. 1 5.7 5.7 5.9 5.9 6 6.1 6 6 6.1 6.1 6.1 6 6 6.1 6 No.2 5.6 5.8 5.8 5.8 5.9 6 5.9 5.9 6 6 6 5.9 5.9 6 5.9 number 3 5.5 5.5 5.7 5.7 6 5.9 5.8 5.8 5.9 5.9 5.9 5.8 5.9 5.9 5.8 4 times 5.5 5.5 5.7 5.7 5.9 5.9 5.8 5.8 5.9 5.9 5.9 5.8 5.9 5.9 5.8 number 5 5.6 5.6 5.8 5.8 5.9 6 5.9 5.9 6 6 6 5.9 6 6.1 5.9 number 6 5.5 5.5 5.7 5.7 5.8 5.9 5.8 5.8 5.9 5.9 5.9 5.8 5.9 6 5.8 number 7 5.4 5.4 5.6 5.6 5.7 5.8 5.7 5.7 5.8 6 6 5.9 5.9 6.1 5.8 number 8 5.3 5.3 5.5 5.5 5.6 5.7 5.6 5.8 5.9 5.9 5.9 5.9 5.9 6 5.7 number 9 5.4 5.4 5.6 5.6 5.7 5.8 5.7 5.9 6 6 6 5.9 5.9 6.1 5.8 No. 10 5.2 5.2 5.4 5.4 5.5 5.6 5.5 5.7 5.8 5.9 5.9 5.8 5.9 6 5.6 Overall average (H) 5.8

Example 2 Sleep time according to intake test subject 1 day 2 days 3 days 4 days 5 days 6 days 7 days 8 days 9 days 10 days 11 days 12 days 13th 14 days average no. 1 4.1 4.1 4.3 4.3 4.2 4.3 4.2 4.4 4.3 4.3 4.5 4.4 4.4 4.5 4.3 No.2 4 4.2 4.2 4.2 4.1 4.2 4.1 4.3 4.2 4.2 4.4 4.3 4.3 4.4 4.2 number 3 3.9. 3.9 4.1 4.1 4.2 4.1 4 4.2 4.1 4.1 4.3 4.2 4.3 4.3 4.1 4 times 3..9 3.9 4.1 4.1 4.1 4.1 4 4.2 4.1 4.1 4.3 4.2 4.3 4.3 4.1 number 5 4 4 4.2 4.2 4.1 4.2 4.1 4.3 4.2 4.2 4.4 4.3 4.4 4.5 4.2 number 6 3.9. 3.9 4.1 4.1 4 4.1 4 4.2 4.1 4.1 4.3 4.2 4.3 4.4 4.1 number 7 3.8 3.8 4 4 3.9 4 3.9 4.1 4 4.2 4.4 4.3 4.3 4.5 4.1 number 8 3.7 3.7 3.9 3.9 3.8 3.9 3.8 4.2 4.1 4.1 4.3 4.3 4.3 4.4 4.0 number 9 3.8 3.8 4 4 3.9 4 3.9 4.3 4.2 4.2 4.4 4.3 4.3 4.5 4.1 No. 10 3.6 3.6 3.8 3.8 3.7 3.8 3.7 4.1 4 4.1 4.3 4.2 4.3 4.4 4.0 Overall average (H) 4.1

Example 3 Sleep time according to intake test subject 1 day 2 days 3 days 4 days 5 days 6 days 7 days 8 days 9 days 10 days 11 days 12 days 13th 14 days average no. 1 5.2 5.2 5.4 5.4 5.3 5.4 5.3 5.5 5.4 5.4 5.4 5.3 5.3 5.4 5.4 No.2 5.1 5.3 5.3 5.3 5.2 5.3 5.2 5.4 5.3 5.3 5.3 5.2 5.2 5.3 5.3 number 3 5 5 5.2 5.2 5.3 5.2 5.1 5.3 5.2 5.2 5.2 5.1 5.2 5.2 5.2 4 times 5 5. 5.2 5.2 5.2 5.2 5.1 5.3 5.2 5.2 5.2 5.1 5.2 5.2 5.2 number 5 5.1 5.1 5.3 5.3 5.2 5.3 5.2 5.4 5.3 5.3 5.3 5.2 5.3 5.4 5.3 number 6 5 5 5.2 5.2 5.1 5.2 5.1 5.3 5.2 5.2 5.2 5.1 5.2 5.3 5.2 number 7 4.9 4.9 5.1 5.1 5 5.1 5 5.2 5.1 5.3 5.3 5.2 5.2 5.4 5.1 number 8 4.8 4.8 5 5 4.9 5 4.9 5.3 5.2 5.2 5.2 5.2 5.2 5.3 5.1 number 9 4.9 4.9 5.1 5.1 5 5.1 5 5.4 5.3 5.3 5.3 5.2 5.2 5.4 5.2 No. 10 4.7 4.7 4.9 4.9 4.8 4.9 4.8 5.2 5.1 5.2 5.2 5.1 5.2 5.3 5.0 Overall average (H) 5.2

As a result, as shown in Tables 5 to 10, it was confirmed that the concentrated mixture of Example 1-1 had a significant sleep improvement effect.

Specifically, in the case of Example 2, in which the stem and red ginseng raw materials were excluded, the total average sleep induction time was 8.2 minutes, which was about 7.5 minutes shorter than Example 3, but about 1.5 minutes later than Example 1-1. In the case of Example 2, the average sleep time was 4.1 hours, showing the lowest sleep time among the three samples. In the case of Example 3, the sleep induction time was the longest among the three samples, but the sleep time was 5.2 hours. It appeared longer than Example 2, and in the case of Example 1-1, the sleep induction time was an average of 6.7 minutes and the sleep time was an average of 5.8 hours, reducing the sleep latency time and increasing the sleep time. Through this, the concentrated mixture of Example 1-1 It was found that both the sleep induction effect and the sleep disorder improvement effect were excellent when ingested.

Experimental Example 2. Confirmation of Pittsburgh sleep quality index improvement effect of concentrated mixture

In order to evaluate the sleep quality improvement effect of the concentrated mixture of the present invention, after ingestion of the concentrated mixture prepared in Example 1-1, the Pittsburgh sleep quality index was measured in the following manner.

Commonly used tools for measuring sleep include the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), and the Epworth Sleepiness Scale (ESS), but universal sleep In order to confirm various aspects of efficiency or sleep, the present invention used the Pittsburgh sleep quality index. In Korea, the reliability and validity of the Korean PSQI (PSQI-K) were verified, and the experiment was conducted as follows (Journal of Convergence for Information Technology Vol. 10. No. 11, pp. 148-155, 2020.).

Twenty men and women with sleep difficulties were selected and used as test subjects. In the same manner as in Experimental Example 1, 20 subjects were allowed to drink 100 mL of the concentrated mixture prepared by the method of Example 1-1 every day for 14 days. In order to confirm the effect of improving the quality of sleep, the effect on the induction of sleep in the human body was measured before intake of the concentrated mixture, after intake before bedtime for a week, and intake before bedtime for a week, and after stopping intake for a week, the effect on the induction of sleep in the human body was measured. The results are shown in Figures 1 to 4.

On the other hand, the Pittsburgh sleep quality index items used in the experiment are described in FIG. 1, and specifically, sleep quality (1 question), sleep latency (2 questions), sleep period (1 question), and sleep efficiency (1 question) , sleep disturbance (9 items), sleep medication use (1 item), and daytime dysfunction (2 items), consisting of 7 items and 18 items. From the points, it shows up to 21 points indicating serious sleep problems, and if it exceeds 5 points, it means that the quality of sleep is poor.

Figure 2 shows the evaluation (primary evaluation) of the quality of sleep for one month before taking the concentrated mixture of the present invention. As shown in FIG. 2, 5 out of 7 items show a high score of 1.5 or more, and in particular, the score of the Pittsburgh sleep quality index before intake is 12.29 points, which is the 5 suggested by Buysse et al. (Buysse et al., 1989). was found to exceed the

Figure 3 shows the evaluation (secondary evaluation) of the results after ingesting the concentrated mixture of the present invention for one week after the first evaluation of the Pittsburgh sleep quality index. When compared with the results of the first evaluation, it was 6.25 points compared to the first evaluation, which was 12.29 points, which was half the level. In addition, looking at the seven items, it was confirmed that the "subjective sleep quality" item significantly improved sleep quality from 2.29 points to 0.5 points. It was confirmed that the sleep quality index decreased in all seven items, and it was confirmed that the sleep duration and sleep latency were reduced by almost half, confirming the excellent effect of the present invention.

4 is a result of evaluating the quality of sleep for a week after one week after the second evaluation of the Pittsburgh sleep quality index. As a result, it was confirmed as 7 points, an increase from the secondary evaluation score of 6.25 points, and through this, it was confirmed that the quality of sleep was specifically improved through the intake of the concentrated mixture of the present invention. Among the 7 items, "habitual sleep effect" decreased as the 1st evaluation progressed to the 2nd evaluation, but it was confirmed that it returned to the original habit after stopping intake, and "subjective sleep quality" and "sleep period" In the item, it was confirmed that the index increased after the end of intake compared to after intake of the concentrated mixture, and the value increased to a similar extent to the index value before intake.

Summarizing the above results, as a result of evaluating the quality of sleep for a period of one month before intake of the concentrated mixture of the present invention, one week after intake, and one week after stopping intake, the results of 12.29 points, 6.25 points, and 7 points were obtained, respectively, according to the present invention. The evaluation index before and after ingestion of the composition showed a difference of about 2 times, and through this, it was found that the concentrated mixture of the present invention has technical features that significantly improve the quality of sleep.

The above description of the present invention is for illustrative purposes, and those skilled in the art can understand that it can be easily modified into other specific forms without changing the technical spirit or essential features of the present invention. There will be. Therefore, the embodiments described above should be understood as illustrative in all respects and not limiting. For example, each component described as a single type may be implemented in a distributed manner, and similarly, components described as distributed may be implemented in a combined form.

The scope of the present invention is indicated by the following claims rather than the detailed description above, and all changes or modifications derived from the meaning and scope of the claims and equivalent concepts should be construed as being included in the scope of the present invention. do.

Claims (12)

A food composition for inducing sleep or improving sleep disorders, containing as an active ingredient extract powder of cinnamon, wheat, lotus root, jujube, jujube seed, gardenia, bokryeong, red ginseng, and Ecklonia cava,
Based on 100 parts by weight of the total, 15 to 25 parts by weight of prickly pear stem, 10 to 20 parts by weight of wheat, 10 to 20 parts by weight of lotus meat, 10 to 20 parts by weight of jujube, 5 to 15 parts by weight of jujube seeds, 5 to 15 parts by weight of gardenia, A food composition for inducing sleep or improving sleep disorders, comprising 5 to 15 parts by weight of bokryeong, 0.5 to 5 parts by weight of red ginseng, and 1 to 10 parts by weight of Ecklonia cava extract powder.
delete According to claim 1,
The sleep induction is sleep induction or sleep disorder improvement food composition, characterized in that through the reduction of the elevation time or increase of the sleep duration.
According to claim 1,
The sleep disorders include somnolence disorder, deep sleep disorder, moderate awakening, early awakening, insomnia, nightmare, sleepwalking, narcolepsy, abnormal behavior during sleep, hypersomnia, sleep seizure, breathing related sleep disorder, apnea, circadian rhythm sleep disorder, incident A food composition for inducing sleep or improving sleep disorders, characterized in that it is at least one selected from the group consisting of sleep, restless leg syndrome, and periodic limb movement syndrome.
A health functional food composition for inducing sleep or improving sleep disorders, containing as active ingredients extracts of cinnamon, wheat, lotus root, jujube, jujube seeds, gardenia, bokryeong, red ginseng, and Ecklonia cava extract powder,
Based on 100 parts by weight of the total, 15 to 25 parts by weight of prickly pear stem, 10 to 20 parts by weight of wheat, 10 to 20 parts by weight of lotus meat, 10 to 20 parts by weight of jujube, 5 to 15 parts by weight of jujube seeds, 5 to 15 parts by weight of gardenia, A health functional food composition for inducing sleep or improving sleep disorders, comprising 5 to 15 parts by weight of bokryeong, 0.5 to 5 parts by weight of red ginseng, and 1 to 10 parts by weight of Ecklonia cava extract powder.
delete According to claim 5,
The sleep induction is a functional food composition for sleep induction or sleep disorder improvement, characterized in that for the reduction of sleep time or increase of sleep duration.
According to claim 5,
The sleep disorders include somnolence disorder, deep sleep disorder, moderate awakening, early awakening, insomnia, nightmare, sleepwalking, narcolepsy, abnormal behavior during sleep, hypersomnia, sleep seizure, breathing related sleep disorder, apnea, circadian rhythm sleep disorder, incident A health functional food composition for inducing sleep or improving sleep disorders, characterized in that it is at least one selected from the group consisting of sleep, restless legs syndrome, and periodic limb movement syndrome.
A pharmaceutical composition for the prevention or treatment of sleep disorders, containing as active ingredients a prickly pear stem, wheat, lotus root, jujube, jujube seed, gardenia, bokryeong, red ginseng, and Ecklonia cava extract powder,
Based on 100 parts by weight of the total, 15 to 25 parts by weight of prickly pear stem, 10 to 20 parts by weight of wheat, 10 to 20 parts by weight of lotus meat, 10 to 20 parts by weight of jujube, 5 to 15 parts by weight of jujube seeds, 5 to 15 parts by weight of gardenia, A pharmaceutical composition for preventing or treating sleep disorders, comprising 5 to 15 parts by weight of bokryeong, 0.5 to 5 parts by weight of red ginseng, and 1 to 10 parts by weight of Ecklonia cava extract powder.
delete delete According to claim 9,
The sleep disorder is sleep disorder prevention or treatment, characterized in that any one or more selected from the group consisting of sleep disorder, sleep maintenance disorder, moderate awakening, early awakening, insomnia, circadian rhythm sleep disorder, sleep incidents Pharmaceutical composition.

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