KR102440039B9 - 흡입전달용 핵산 또는 단백질 탑재 폐 계면활성제입자 및 이의 제조 방법 - Google Patents

흡입전달용 핵산 또는 단백질 탑재 폐 계면활성제입자 및 이의 제조 방법

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Publication number
KR102440039B9
KR102440039B9 KR1020210016442A KR20210016442A KR102440039B9 KR 102440039 B9 KR102440039 B9 KR 102440039B9 KR 1020210016442 A KR1020210016442 A KR 1020210016442A KR 20210016442 A KR20210016442 A KR 20210016442A KR 102440039 B9 KR102440039 B9 KR 102440039B9
Authority
KR
South Korea
Prior art keywords
protein
loaded
manufacturing
nucleic acid
pulmonary surfactant
Prior art date
Application number
KR1020210016442A
Other languages
English (en)
Other versions
KR20210100032A (ko
KR102440039B1 (ko
Inventor
박지호
오찬희
Original Assignee
한국과학기술원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국과학기술원 filed Critical 한국과학기술원
Publication of KR20210100032A publication Critical patent/KR20210100032A/ko
Application granted granted Critical
Publication of KR102440039B1 publication Critical patent/KR102440039B1/ko
Publication of KR102440039B9 publication Critical patent/KR102440039B9/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1275—Lipoproteins; Chylomicrons; Artificial HDL, LDL, VLDL, protein-free species thereof; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
KR1020210016442A 2020-02-05 2021-02-05 흡입전달용 핵산 또는 단백질 탑재 폐 계면활성제입자 및 이의 제조 방법 KR102440039B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020200013867 2020-02-05
KR20200013867 2020-02-05

Publications (3)

Publication Number Publication Date
KR20210100032A KR20210100032A (ko) 2021-08-13
KR102440039B1 KR102440039B1 (ko) 2022-09-05
KR102440039B9 true KR102440039B9 (ko) 2023-03-23

Family

ID=77200771

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020210016442A KR102440039B1 (ko) 2020-02-05 2021-02-05 흡입전달용 핵산 또는 단백질 탑재 폐 계면활성제입자 및 이의 제조 방법

Country Status (8)

Country Link
US (1) US20230092682A1 (ko)
EP (1) EP4085900A4 (ko)
JP (1) JP2023513132A (ko)
KR (1) KR102440039B1 (ko)
CN (1) CN115052585A (ko)
AU (1) AU2021215673A1 (ko)
CA (1) CA3165626A1 (ko)
WO (1) WO2021158053A1 (ko)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436708B1 (en) * 1997-04-17 2002-08-20 Paola Leone Delivery system for gene therapy to the brain
JP2001002592A (ja) * 1999-06-18 2001-01-09 Dai Ichi Seiyaku Co Ltd 遺伝子導入用組成物
JP2003012503A (ja) * 2001-06-22 2003-01-15 Techno Network Shikoku Co Ltd 脂質ベシクルおよび遺伝子を固定化する方法
CA2690089A1 (en) * 2007-06-05 2008-12-11 Paka Pulmonary Pharmaceuticals, Inc. Lung surfactant drug conjugates and uses thereof
WO2012017406A1 (en) * 2010-08-05 2012-02-09 Indian Institute Of Technology (Iit), Bombay Exogenous pulmonary surfactant preparation comprising a phospholipid and an adjuvans
CN103550783A (zh) * 2013-04-27 2014-02-05 中国人民解放军军事医学科学院放射与辐射医学研究所 一种核酸类药物靶向递送系统及其制备方法
US20210121578A1 (en) * 2018-05-18 2021-04-29 Korea Advanced Institute Of Science And Technology Lung surfactant-based anticancer drug

Also Published As

Publication number Publication date
WO2021158053A1 (ko) 2021-08-12
US20230092682A1 (en) 2023-03-23
CN115052585A (zh) 2022-09-13
KR20210100032A (ko) 2021-08-13
AU2021215673A1 (en) 2022-09-08
CA3165626A1 (en) 2021-08-12
JP2023513132A (ja) 2023-03-30
EP4085900A1 (en) 2022-11-09
KR102440039B1 (ko) 2022-09-05
EP4085900A4 (en) 2023-07-26

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E90F Notification of reason for final refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
G170 Re-publication after modification of scope of protection [patent]