KR102437228B1 - 인위적으로 조작된 sc 기능 조절 시스템 - Google Patents

인위적으로 조작된 sc 기능 조절 시스템 Download PDF

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KR102437228B1
KR102437228B1 KR1020170126636A KR20170126636A KR102437228B1 KR 102437228 B1 KR102437228 B1 KR 102437228B1 KR 1020170126636 A KR1020170126636 A KR 1020170126636A KR 20170126636 A KR20170126636 A KR 20170126636A KR 102437228 B1 KR102437228 B1 KR 102437228B1
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nucleotide sequence
complementary
nucleic acid
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KR20180054427A (ko
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김석중
송동우
홍영빈
최병옥
이재영
이정민
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주식회사 툴젠
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]

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  • Animal Behavior & Ethology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020170126636A 2016-11-14 2017-09-28 인위적으로 조작된 sc 기능 조절 시스템 Active KR102437228B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020220105836A KR102621539B1 (ko) 2016-11-14 2022-08-24 인위적으로 조작된 sc 기능 조절 시스템

Applications Claiming Priority (2)

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US201662421516P 2016-11-14 2016-11-14
US62/421,516 2016-11-14

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KR20180054427A KR20180054427A (ko) 2018-05-24
KR102437228B1 true KR102437228B1 (ko) 2022-08-30

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KR1020220105836A Active KR102621539B1 (ko) 2016-11-14 2022-08-24 인위적으로 조작된 sc 기능 조절 시스템

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US (1) US12331086B2 (enExample)
EP (2) EP3896162B1 (enExample)
JP (1) JP7338937B2 (enExample)
KR (2) KR102437228B1 (enExample)
CN (1) CN110248957B (enExample)
AU (1) AU2017358122B2 (enExample)
BR (1) BR112019009725A2 (enExample)
RU (2) RU2022105597A (enExample)
WO (1) WO2018088694A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019066490A2 (ko) * 2017-09-28 2019-04-04 주식회사 툴젠 유전자 발현 조절을 위한 인위적인 게놈 조작
US11572574B2 (en) 2017-09-28 2023-02-07 Toolgen Incorporated Artificial genome manipulation for gene expression regulation
EP3851528A4 (en) * 2018-09-12 2023-12-06 Institute for Basic Science COMPOSITION FOR INDUCATING DEATH OF CELLS HAVING MUTATED GENE AND METHOD FOR INDUCATING DEATH OF CELLS HAVING MODIFIED GENE USING THE COMPOSITION
GB201907882D0 (en) 2019-06-03 2019-07-17 Cyprus Foundation For Muscular Dystrophy Res Methods
EP3798301A1 (en) * 2019-09-25 2021-03-31 KWS SAAT SE & Co. KGaA Promoter repression
WO2021184021A1 (en) * 2020-03-13 2021-09-16 Codiak Biosciences, Inc. Extracellular vesicle-aso constructs targeting pmp22
CN114621922A (zh) * 2022-02-15 2022-06-14 中山大学附属第五医院 一种大鼠海绵体神经来源施旺细胞的提取纯化和培养方法
WO2025079278A1 (ja) * 2023-10-10 2025-04-17 国立大学法人 東京医科歯科大学 シャルコー・マリー・トゥース病の処置剤

Citations (1)

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Publication number Priority date Publication date Assignee Title
KR101656237B1 (ko) * 2012-10-23 2016-09-12 주식회사 툴젠 표적 DNA에 특이적인 가이드 RNA 및 Cas 단백질을 암호화하는 핵산 또는 Cas 단백질을 포함하는, 표적 DNA를 절단하기 위한 조성물 및 이의 용도

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KR100613038B1 (ko) * 2004-07-07 2006-08-16 공주대학교 산학협력단 염색체 17ｐ11.2-ｐ12 지역의 중복을 제외한 유전자돌연변이를 발병 원인으로 하는 ＣＭＴ 질환의 진단방법및 진단키트
WO2008154644A1 (en) * 2007-06-12 2008-12-18 Case Western Reserve University Targeted cell death
SG10201707569YA (en) * 2012-12-12 2017-10-30 Broad Inst Inc Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications
ES2777217T3 (es) * 2013-06-17 2020-08-04 Broad Inst Inc Suministro, modificación y optimización de sistemas de guía en tándem, métodos y composiciones para la manipulación de secuencias
WO2015048577A2 (en) * 2013-09-27 2015-04-02 Editas Medicine, Inc. Crispr-related methods and compositions
KR20160102056A (ko) * 2013-12-26 2016-08-26 더 제너럴 하스피탈 코포레이션 멀티플렉스 가이드 ｒｎａ
US9970001B2 (en) * 2014-06-05 2018-05-15 Sangamo Therapeutics, Inc. Methods and compositions for nuclease design
WO2016021973A1 (ko) * 2014-08-06 2016-02-11 주식회사 툴젠 캄필로박터 제주니 crispr/cas 시스템 유래 rgen을 이용한 유전체 교정
WO2017070632A2 (en) 2015-10-23 2017-04-27 President And Fellows Of Harvard College Nucleobase editors and uses thereof

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
KR101656237B1 (ko) * 2012-10-23 2016-09-12 주식회사 툴젠 표적 DNA에 특이적인 가이드 RNA 및 Cas 단백질을 암호화하는 핵산 또는 Cas 단백질을 포함하는, 표적 DNA를 절단하기 위한 조성물 및 이의 용도

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Publication number Publication date
EP3539980A4 (en) 2020-10-07
EP3539980A2 (en) 2019-09-18
KR102621539B1 (ko) 2024-01-09
BR112019009725A2 (pt) 2019-11-19
CN110248957A (zh) 2019-09-17
EP3896162A1 (en) 2021-10-20
AU2017358122A1 (en) 2019-07-04
JP7338937B2 (ja) 2023-09-05
RU2019118283A3 (enExample) 2021-04-26
US12331086B2 (en) 2025-06-17
EP3896162B1 (en) 2025-03-05
KR20180054427A (ko) 2018-05-24
RU2022105597A (ru) 2022-04-04
US20190276503A1 (en) 2019-09-12
RU2019118283A (ru) 2020-12-14
WO2018088694A3 (ko) 2018-08-09
CA3043148A1 (en) 2018-05-17
AU2017358122B2 (en) 2022-12-22
RU2768043C2 (ru) 2022-03-23
CN110248957B (zh) 2023-12-19
WO2018088694A2 (ko) 2018-05-17
JP2019537446A (ja) 2019-12-26
KR20220122592A (ko) 2022-09-02

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