KR102430298B1 - 플루오로카본-결합 펩티드 제제 - Google Patents

플루오로카본-결합 펩티드 제제 Download PDF

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KR102430298B1
KR102430298B1 KR1020227002651A KR20227002651A KR102430298B1 KR 102430298 B1 KR102430298 B1 KR 102430298B1 KR 1020227002651 A KR1020227002651 A KR 1020227002651A KR 20227002651 A KR20227002651 A KR 20227002651A KR 102430298 B1 KR102430298 B1 KR 102430298B1
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fluorocarbon
peptide
delete delete
aqueous solution
peptides
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KR20220017519A (ko
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칼튼 브래들리 브라운
베르트랑 빅토르 질베르 조르쥬
장 프랑수와 타뷔레
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알티뮨 유케이 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
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    • A61K39/385—Haptens or antigens, bound to carriers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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    • A61K2039/541—Mucosal route
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/544—Mucosal route to the airways
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
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  • Genetics & Genomics (AREA)
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  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020227002651A 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제 Active KR102430298B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1022147.1 2010-12-31
GB201022147A GB201022147D0 (en) 2010-12-31 2010-12-31 Formulation
KR1020217004652A KR102356875B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
PCT/GB2011/001781 WO2012090002A1 (en) 2010-12-31 2011-12-30 Fluorocarbon-linked peptide formulation

Related Parent Applications (1)

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KR1020217004652A Division KR102356875B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제

Publications (2)

Publication Number Publication Date
KR20220017519A KR20220017519A (ko) 2022-02-11
KR102430298B1 true KR102430298B1 (ko) 2022-08-05

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KR1020227002651A Active KR102430298B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020207011186A Expired - Fee Related KR102219009B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020197024473A Active KR102103920B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020137020378A Expired - Fee Related KR101905749B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020217004652A Expired - Fee Related KR102356875B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020187028311A Expired - Fee Related KR102014919B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제

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KR1020207011186A Expired - Fee Related KR102219009B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020197024473A Active KR102103920B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020137020378A Expired - Fee Related KR101905749B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020217004652A Expired - Fee Related KR102356875B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020187028311A Expired - Fee Related KR102014919B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제

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Country Link
US (4) US9119811B2 (OSRAM)
EP (1) EP2658572B1 (OSRAM)
JP (3) JP6054302B2 (OSRAM)
KR (6) KR102430298B1 (OSRAM)
CN (2) CN103429259A (OSRAM)
AU (1) AU2011350997B2 (OSRAM)
BR (1) BR112013016870A2 (OSRAM)
CA (1) CA2823453C (OSRAM)
CL (1) CL2013001935A1 (OSRAM)
DK (1) DK2658572T3 (OSRAM)
EA (1) EA028396B1 (OSRAM)
ES (1) ES2645017T3 (OSRAM)
GB (2) GB201022147D0 (OSRAM)
IL (1) IL227273A0 (OSRAM)
MX (1) MX348954B (OSRAM)
WO (1) WO2012090002A1 (OSRAM)
ZA (1) ZA201305591B (OSRAM)

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GB0408164D0 (en) 2004-04-13 2004-05-19 Immune Targeting Systems Ltd Antigen delivery vectors and constructs
GB0716992D0 (en) 2007-08-31 2007-10-10 Immune Targeting Systems Its L Influenza antigen delivery vectors and constructs
GB201022147D0 (en) 2010-12-31 2011-02-16 Immune Targeting Systems Its Ltd Formulation
GB201223386D0 (en) 2012-12-24 2013-02-06 Immune Targeting Systems Its Ltd Vaccine
GB201315946D0 (en) * 2013-09-06 2013-10-23 Immune Targeting Systems Its Ltd Oncology vaccine
GB201321242D0 (en) 2013-12-02 2014-01-15 Immune Targeting Systems Its Ltd Immunogenic compound
TW202241500A (zh) * 2015-06-09 2022-11-01 美商博德研究所有限公司 用於贅瘤疫苗之調配物及其製備方法
KR20240149976A (ko) 2017-04-04 2024-10-15 바린투스 바이오테라퓨틱스 노쓰 아메리카, 인크. 펩티드-기반 백신, 그의 제조 방법, 및 면역 반응을 유도하기 위한 그의 용도
CN118384268A (zh) 2017-04-18 2024-07-26 阿尔尼拉姆医药品有限公司 具有乙肝病毒（hbv）感染的受试者的治疗方法
CN112423787A (zh) * 2018-07-10 2021-02-26 思齐乐私人有限公司 团聚物的去除
WO2022015662A1 (en) * 2020-07-12 2022-01-20 Altimmune, Inc Coronavirus immunogenic t cell epitope compositions and uses thereof
WO2024186890A1 (en) 2023-03-06 2024-09-12 Intellia Therapeutics, Inc. Compositions and methods for hepatitis b virus (hbv) genome editing

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US5055562A (en) 1988-02-01 1991-10-08 Biomira, Inc. Fluorocarbon chain-containing antigenic conjugates
US6828415B2 (en) 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
DE4305225A1 (de) * 1993-02-19 1994-08-25 Asta Medica Ag Neues Herstellverfahren für Cetrorelix Lyophilisat
FR2771640B1 (fr) * 1997-12-03 2000-02-11 Inst Nat Sante Rech Med Micelles mixtes de lipopeptides pour l'induction d'une reponse immunitaire et leurs utilisations a des fins therapeutiques
ATE381945T1 (de) * 2004-03-12 2008-01-15 Intercell Ag Verfahren zur solubilisierung von peptid- mischungen
GB0408164D0 (en) 2004-04-13 2004-05-19 Immune Targeting Systems Ltd Antigen delivery vectors and constructs
GB0716992D0 (en) * 2007-08-31 2007-10-10 Immune Targeting Systems Its L Influenza antigen delivery vectors and constructs
GB201022147D0 (en) 2010-12-31 2011-02-16 Immune Targeting Systems Its Ltd Formulation
GB201223386D0 (en) * 2012-12-24 2013-02-06 Immune Targeting Systems Its Ltd Vaccine

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WO2012090002A1 (en) 2012-07-05
KR102103920B1 (ko) 2020-04-23
US20210038710A1 (en) 2021-02-11
US20240042007A1 (en) 2024-02-08
MX2013007635A (es) 2013-12-02
KR102356875B1 (ko) 2022-02-08
KR20140071952A (ko) 2014-06-12
KR20200043532A (ko) 2020-04-27
KR102014919B1 (ko) 2019-08-27
KR20210021128A (ko) 2021-02-24
GB201313381D0 (en) 2013-09-11
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