KR102424317B1 - A foaming composition for mouthwash and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a base A prepared by mixing a component comprising at least one component selected from the group consisting of sodium hydrogen carbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, and iron carbonate, sodium stannate, and ethylenediaminetetraacetate, malic acid, Base B prepared by mixing ingredients containing aspartame and at least one organic acid selected from the group consisting of citric acid, tartaric acid, gluconic acid, succinic acid and tartaric acid, and at least one material selected from the group consisting of plant extract and base B, and polyvinylpyrrol In the method of manufacturing an effervescent tablet for oral cleaning, which is prepared by mixing a base C containing money and colloidal silicon dioxide and a lubricant base D containing mannitol, first put the base C into the mixer, and then put the base B It relates to a method for producing an effervescent tablet for mouthwash, characterized in that mixing, then adding and mixing the base A, and finally adding and mixing the base D, and the tablet manufactured by the method, the method of the present invention Silver has the effect of reducing the binding force in the tableting step and improving the natural oxidation and decomposition of the raw material.

Description

Effervescent tablet for oral cleaning and manufacturing method thereof

The present invention relates to an effervescent tablet for mouthwash and a method for manufacturing the same, and more particularly, in a method for manufacturing an effervescent tablet for mouthwash, through the development and mixing method of main ingredients, the addition of oil-soluble substances is It relates to an easy manufacturing method.

Classified as functional ingredients for the manufacture of effervescent tablets for mouthwash, there are foaming agents, abrasives, organic acids, foaming agents, bond formers, and the like.

Known effervescent tablets for oral cleaning are selected for the purpose of dental health and effervescence, one or more raw materials from among sodium bicarbonate, ammonium bicarbonate, potassium bicarbonate, iron carbonate, etc. For crystalline cellulose, powdered cellulose, dietary fiber, and the like, as an abrasive, silicon dioxide, calcium monohydrogen phosphate, calcium carbonate, aluminum hydroxide, precipitated silica, hydrous silicic acid, silica gel, aluminosilicate, etc. or a mixture of one or more, It is an organic acid that causes foaming through carbon dioxide generation in the oral cavity. It is manufactured by mixing one or more mixtures of citric acid, tartaric acid, malic acid, gluconic acid, succinic acid, etc. .

In addition, for effects other than the oral hygiene and cleaning effects provided by the above general oral cleaning effervescent tablets, plant extracts such as rosemary, green tea extract, and sage are used to remove bad breath and to improve palatability. Sometimes, peppermint oil, spearmint oil, lavender oil, etc. are selected and used. In addition, lactose, maltose, sodium saccharin, aspartame, stevioside, licoric acid, etc. are selected as sweetening ingredients and added during tablet manufacturing, or sodium fluoride or fluorine-based compounds known for the purpose of preventing tooth decay are also used. .

The existing known method for producing an effervescent formulation for mouthwash is a basic manufacturing method of a simple mixing of a foaming agent and an organic acid that induces foaming in the oral cavity, which exhibits a taste enough to cause objection from users. , and it is the organic acid that gives sour taste.

The reality is that such a manufacturing method has a significant effect on the preference of the product and acts as a negative factor on product sales.

Accordingly, there is a need for a method of manufacturing a formulation that enhances the feeling of use while including the advantages of an effervescent formulation.

In addition, modern people prefer products that claim versatility in product selection, and in the case of oral cleaning products, there is a high demand for products with complex functions such as dry mouth, bad breath removal, and tooth decay prevention. However, there is a limit to using fragrances or vegetable extracts with safe functionality that can be used in the oral cavity in the form of oils or liquids in effervescent formulations for mouthwash, which have poor storability due to low defectivity in the tableting stage, In some cases, rapid changes in product properties due to oxidation and decomposition may appear, so an appropriate manufacturing method for the use of various functional materials is required.

[Prior Patent Literature]

Republic of Korea Patent No. 10-1056573

The present invention has been devised by the above necessity, and an object of the present invention is to reduce the user's objection to the existing foaming agents and organic acids, increase the original oral cleaning and anti-cavity functionality, and various fragrances and extracts for aesthetics. It is to provide a novel method for manufacturing an effervescent tablet for oral cleaning that can use functional materials.

In order to achieve the above object, the present invention is prepared by mixing one or more components selected from the group consisting of sodium hydrogen carbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, and iron carbonate, sodium stannate, and a component comprising ethylenediaminetetraacetate Base A, which is prepared by mixing ingredients containing aspartame and at least one organic acid selected from the group consisting of malic acid, citric acid, tartaric acid, gluconic acid, succinic acid and tartaric acid, with base B, fragrance, and one selected from the group consisting of plant extracts In the method for producing an effervescent tablet for mouthwash prepared by mixing the above substances with a base C comprising polyvinylpyrrolidone and colloidal silicon dioxide and a lubricant base D comprising mannitol, first, base C is put in a mixer, and the base material B is then added and mixed, then the base A is added and mixed, and finally the base D is added and mixed.

In one embodiment of the present invention, it is preferable that sodium stannate and ethylenediaminetetraacetate are separately first mixed in the base A to form a mixture and administered, but the present invention is not limited thereto.

In addition, the present invention provides a base A prepared by mixing one or more components selected from the group consisting of sodium hydrogen carbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, and iron carbonate, sodium stannate, and ethylenediaminetetraacetate, and malic acid. , citric acid, tartaric acid, gluconic acid, succinic acid and tartaric acid and one or more organic acids selected from the group consisting of tartaric acid and base B prepared by mixing ingredients containing aspartame and fragrance, and one or more substances selected from the group consisting of plant extracts and polyvinyl peel Effervescent tablets for mouthwash prepared by mixing Base C containing rollidone and colloidal silicon dioxide and Lubricating Base D including mannitol A composition is provided.

In one embodiment of the present invention, the composition preferably has antibacterial activity against bacteria selected from the group consisting of the genus Streptococcus sanguis, Streptococcus mutans, Lactobacillus casei, and Acetinobacillus, but is not limited thereto.

Hereinafter, the present invention will be described.

In the present invention, the method for producing a novel effervescent formulation for mouthwash is used in the oral cavity with the existing effervescent agent.

The simple mixing of organic acids that induce foaming improves the basic manufacturing method, and in the raw material pretreatment process, as shown in Table 1, it can be divided into base, acid, fragrance (extract), and lubricant to make raw materials, and functionally a foaming agent and organic acid It features a manufacturing method for formulating each. In addition, by separating the base of the fragrance (the extract), it is possible to prepare a group of base materials for additional functionality, that is, the fragrance and functionality, when manufacturing the product, making it easy to diversify the product.

As can be seen from the present invention, the manufacturing method proposed by the present invention has the specificity of the effervescent material in the manufacturing method, that is, the reduction in binding force and the natural oxidation of raw materials in the tableting step, compared to the conventional batch mixing method. and degradation were confirmed.

Hereinafter, the present invention will be described in more detail through non-limiting examples. However, the following examples are intended to illustrate the present invention, and the scope of the present invention is not to be construed as being limited by the following examples.

[ Example 1 -10]

Pretreatment of raw materials

Weigh each substrate according to the mixing ratio as shown in Table 2, mix them in a separate state with a mixer, put them in a dryer, dry them at 70-85 degrees for 1 to 5 hours, grind them to a size of up to 40 mesh or less, and measure the moisture state do. At this time, sodium stannate and ethylenediamine tetraacetate of base A are separately mixed and prepared (substrate A-1).

At this time, it can be seen that the characteristics of the present invention are that the base A and the base B, i.e., the foaming material base such as sodium hydrogen carbonate, and the organic acid base, i.e. the base B, are separated into particles and tableted even at the final tableting.

In addition, the base C is a base material that can smoothly inject the extract for fragrance or functionality to show the characteristics of the product, and adsorbs the fragrance or extract to colloidal silicon dioxide to increase functionality and storability.

mixing of raw materials

To mix the raw materials, first put the base C into the mixer, and after pre-mixing in the mixer for about 1 to 20 minutes, add the base B (acid) and mix again for 5 to 30 minutes. At the end of the input of the base A, it is divided into 4 and mixed for about 5 to 30 minutes, respectively, at this time, the base A-1 is also added and mixed accordingly.

raw material tableting

When the mixing of the raw materials is completed, the base D is put in, mixed for 10 to 20 minutes, then discharged, and tableted with the shape and strength required for commercialization.

Example classification, Examples 1 and 10 are examples prepared as the minimum and maximum values for each raw material allowed in the present invention, and are used as samples for product safety (oxidation, binding force, etc.), and in the case of Examples 2 and 3, specific extracts Formulations for products with product functionality and safety according to the increase in the content of It is a formulation containing licoric acid with various functions by content.

[ Experimental example 1] manufactured oral products Stability (oxidation and binding force)

In the case of effervescent tablets for oral use, when the raw material is oxidized, the gas generation that produces bubbles is reduced, and the oral cleaning effect is reduced. It may cause odor and discoloration that impairs product quality.

In order to measure the oxidation stability of the products for Examples 1 to 10, samples were prepared for each temperature and storage period, the tablets were put in a test tube, and the amount of gas generated was measured to test for product degradation due to oxidation of the tablets.

The amount of gas generated was compared with the control by measuring the amount of carbon dioxide in the test tube. In case of product deterioration, odor generation measurement (SHIMYEI, OMX-SRM) was performed.

The amount of carbon dioxide generated was measured to confirm the degree of oxidation of the effervescent tablet for oral use, and the amount of emission by temperature of the control group was used as a standard. That is, if the amount of carbon dioxide generated from the tablets stored for 5 days at room temperature (about 25 degrees) was 20 cc, and the amount of carbon dioxide generated from the test tablets was 10 cc, it was expressed as 50 (%).

The value of the control group was measured for each Example, and in the case of Formulation A, the sample prepared by the conventional effervescent formulation and manufacturing method, that is, the raw material batch input and tableting method, was also tested as the control group.

Table 3 shows the results of the test. First, looking at the amount of carbon dioxide generated, in the case of Examples 1-10, a slight decrease was shown due to the high temperature and the length of the storage organ, but in the case of Formulation A, 60 degrees and 14 days storage sample , it was confirmed that the amount of carbon dioxide generated was extremely reduced due to the severe degree of oxidation, and the formulation of the present invention showed high oxidation stability.

In addition, as a result of measuring the degree of odor generation, as in the present invention, it can be confirmed that the occurrence of odor is significantly suppressed as shown in Table 3 by mixing and tableting the raw materials for each base material as in the present invention. In the case of Formulation A, it can be seen that, in the case of a sample stored at 60°C and 14 days, the odor is relatively doubled or more.

[ Experimental example 2] intraoral Sterilization effect on pathogenic microorganisms

In order to measure the sterilization effect of the effervescent tablet for mouthwash on pathogenic microorganisms in the oral cavity, four representative oral pathogenic microorganisms, Streptococcus sanguis, Streptococcus mutans, Lactobacillus casei, and Acetinobacillus, were selected, During the test, the stored strain was cultured in anaerobic conditions for at least 24 hours, the number of bacteria was measured, and about ^10-7 bacteria per ml were dispensed, and the dispensed strain was transferred to a 25ml test tube again, and the As shown in 4, solid general toothpaste (1g), oral cleaning solution (commercially available), and oral effervescent tablet sample (840mg) were added, diluted in a solid medium after incubation, and spread on a flat plate to measure the number of bacteria.

In more detail, 1 g of solid toothpaste was weighed and dispersed in a phosphate buffer that had little effect on the bacterial culture, and 0.2 ml of the oral cleaning solution was diluted in 1 ml of phosphate buffer after sterilization, Examples 1 and Examples No. 10 prepared 1 ml of phosphate buffer, put it right before the input, and mixed it with the bacterial culture solution for testing. The data for each formulation and product as above were applied by inferring the degree of oral exposure through a preliminary test. Finally, when the number of bacteria containing only the control, that is, the phosphate buffer was 100, the results were expressed as the number of viable bacteria as a percentage. That is, in Examples 1 and 10, it was confirmed that the number of bacteria was reduced to a high degree.

[ Experimental example 3] Measurement of delayed dispersion effect of effervescent tablets for oral use

In the present invention, base C, which facilitates application of fragrances and extracts, includes colloidal silicon dioxide and desired fragrances and extracts, powdered, and mixed with other raw materials to be tableted. In order to confirm that the product was not dispersed at one time, but dispersed with a delay, thereby increasing the aesthetics and preference of the product, the tablet was exposed under the same conditions as in the oral cavity, and the fragrance and extract dispersed in the reaction solution were analyzed.

In Examples 1, 2, and 3, hutgaehyang, citrus flavor, and coffee flavor were used as flavor components according to the mixing ratio, and for each reference substance, the material analysis table provided by the flavor supplier was referred to, and in the case of extracts, green mandarin extract, jujube Extract and aloe extract were used, and the reference material was nobiletin. For the test method, the same formulation as a control, a product prepared by simple batch mixing and tableting, and a sample prepared by the manufacturing method of the present invention were put in a phosphate buffer, and the reference material was quantified by time period, and this was compared with the control. That is, in the case of the control, it is assumed that it is eluted into a 100% solution immediately upon putting it in the phosphate buffer, and the fragrance components and extract components of Examples 1, 2, and 3 and Examples 6, 7 and 8 were converted into relative values.

As shown in Table 5, in the case of the control, it is quantified 100% at 0 hours, but after that, it is decomposed or disappeared, and it is reduced to almost 35% at 6 hours. However, as a result of analyzing the three fragrances added as base C, it shows that they disperse slowly. In fact, in the case of oral effervescent tablets, it is recommended that the use time is about 30 seconds. In other words, the fragrance and extract are slowly dispersed in the oral cavity from the time the product is used until the end. As a result, it can be seen that the aesthetics and functionality of the product can be improved.

Claims (4)

Sodium hydrogen carbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, and one or more components selected from the group consisting of iron carbonate, sodium stannate, and the base A prepared by mixing a component comprising ethylenediaminetetraacetate, malic acid, citric acid, tartaric acid , gluconic acid, succinic acid and tartaric acid and at least one organic acid selected from the group consisting of tartaric acid and base B prepared by mixing ingredients including aspartame and fragrance, and polyvinylpyrrolidone and colloids with one or more substances selected from the group consisting of plant extracts In the method for manufacturing an effervescent tablet for oral cleaning, which is prepared by mixing a base C containing acid silicon dioxide and a lubricating base D containing mannitol, first put the base C into a mixer, then add the base B and mix, Then, in the method for producing an effervescent tablet for mouthwash prepared by adding and mixing the base A, and finally adding and mixing the base D,
wherein the method comprises 32.0 wt% to 35.0 wt% of one or more components selected from the group consisting of sodium hydrogen carbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, and iron carbonate, 0.3 to 2.6 wt% polyethylene glycol, 0.2 to 0.4 wt% sodium stannate and 0.1 to 0.3% by weight of ethylenediaminetetraacetate, 0.1 to 0.3% by weight of sodium saccharin hydrate, 0.01 to 0.2% by weight of glycyrrhizic acid, and a base A prepared by mixing, malic acid, citric acid, tartaric acid, gluconic acid, Base B prepared by mixing 13.9 to 32.0% by weight of at least one organic acid selected from the group consisting of succinic acid and tartaric acid, 0 to 0.9% by weight of aspartame and 0 to 0.2% by weight of sodium acid pyrophosphate and 0.3 to 1.7% by weight of fragrance %, and a base C comprising 0.3 to 0.4% by weight of a plant extract and 0.3 to 2.6% by weight of polyvinylpyrrolidone and 0.3 to 1.3% by weight of polyvinylpyrrolidone and colloidal silicon dioxide and 1.6 to 5.6% by weight of sodium cocoylglutamate By mixing the lubricating substrate D comprising weight %, hydroxyapatite 0.3 to 1.3 weight %, mannitol 30.3 to 32.0 weight %, and magnesium stearate 0.3 to 3.5 weight %, these substrates are prepared by mixing the substrate A, the substrate B, the substrate C and Prepared by mixing with base D, but
In the above base A, sodium stannate and ethylenediaminetetraacetate are separately mixed first to form a mixture and administered. delete delete delete