KR102417770B1 - antiseptic composition and a cosmetic composition comprising the same - Google Patents

Abstract

The present invention relates to a preservative composition and a cosmetic composition comprising the same, and the preservative composition of the present invention has a surprising antiseptic effect, has little skin irritation, and does not affect the fragrance and color of the cosmetic composition, so it can be easily applied to the cosmetic composition do.

Description

Antiseptic composition and a cosmetic composition comprising the same

The present invention relates to a preservative composition and a cosmetic composition comprising the same, and more particularly, to a preservative composition comprising ethanol and a polyol having a low carbon number as preservative components, and a cosmetic composition comprising the same.

In general, cosmetics are applied to the body, such as skin and hair, suitable for various uses such as cleaning and beautification of the human body, and should have little effect on the human body.

However, because cosmetics basically contain many nutrients, they are easy to become the best source of nutrients for the growth of microorganisms, so microorganisms such as mold and bacteria are easy to penetrate.

For this reason, various types of preservatives have been added and used to protect cosmetics for a long period of time from discoloration and odor caused by microorganisms.

However, the currently used preservatives are used by limiting the type and content of preservatives due to problems that can cause contact dermatitis or stimulate the central nervous system to cause collapse, extreme body temperature drop, and convulsions.

Although Korean Patent Application Laid-Open No. 2005-0041745 provides a cosmetic composition containing 1,2-hexanediol, research on a safer and more effective preservative is needed because it still lacks preservative power and causes skin irritation.

Korea Patent Publication No. 2005-0041745

The present invention provides a safe preservative composition having a strong antiseptic effect and less skin irritation and a cosmetic composition comprising the same, and more specifically, a preservative composition comprising ethanol and C1-C5 polyol as preservative components, and a cosmetic comprising the same provide a composition.

The present invention is to provide a safe preservative composition with excellent antiseptic effect and low side effects such as skin irritation, and the antiseptic composition of the present invention includes ethanol and C1-C5 polyol as preservatives.

The polyol according to an embodiment of the present invention may have 3 to 4 carbon atoms, and preferably glycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, 1,3-propanediol and butylene. It may be one or two or more selected from glycol, more preferably. glycerin, 1.3-butanediol or 1,3-propanediol.

Ethanol and polyol according to an embodiment of the present invention may have a weight ratio of 1:1 to 1:10.

In addition, the present invention provides a cosmetic composition containing the preservative composition according to an embodiment of the present invention.

The preservative composition included in the cosmetic composition according to an embodiment of the present invention may be included in an amount of 5 to 30% by weight based on the total amount of the cosmetic composition.

The preservative composition of the present invention contains ethanol and a low-carbon polyol as preservative components, and has antiseptic power against bacteria, yeast and mold.

In addition, the cosmetic composition comprising the preservative composition of the present invention contains a preservative component, which is a combination of ethanol and a low-carbon polyol, so that skin irritation is low, and it has a surprising antiseptic effect without affecting the fragrance and color of the cosmetic composition.

The present invention provides a safe antiseptic composition with excellent antiseptic effect, particularly against bacteria, yeast, and mold, and low skin irritation. include

The present inventors completed the present invention by discovering that the combination of ethanol and C1-C5 polyols with ethanol and C1-C5 polyols dramatically increased the antiseptic effect and low skin irritation while researching to solve the problems of the preservatives used in the past did

The antiseptic composition of the present invention has very low toxicity because it does not use conventionally used preservatives such as paraoxybenzoic acid ester and imidazoline.

In addition, the preservative composition of the present invention contains ethanol and C1-C5 polyol, and thus has very little skin irritation compared to polyols having 6 or more carbon atoms used in the past. does not cause

The polyol according to an embodiment of the present invention is characterized as a C1-C5 polyol, and may preferably be a polyol having 3 to 4 carbon atoms. More preferably, it may be a diol having 3 to 4 carbon atoms in terms of combination.

Specifically, the polyol according to an embodiment of the present invention may be one or two or more selected from glycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, 1,3-propanediol, and butylene glycol. and more preferably glycerin, 1.3-butanediol or 1,3-propanediol.

Ethanol and polyol according to an embodiment of the present invention may have a weight ratio of 1:1 to 1:10, preferably in terms of having an appropriate viscosity and low skin irritation while having an antiseptic and moisturizing effect. It may be 1 to 1: 5.

The antiseptic composition of the present invention may be for preventing spoilage by yeasts, molds and bacteria, but is not limited, and the yeast may be yeast, Candia albicans, and the mold may be Aspergillus brazilians, and bacteria is effective in the case of E. coli, P. aeruginosa, S. aureus or a mixture thereof.

The present invention also provides a cosmetic composition comprising the preservative composition of the present invention.

The cosmetic composition of the present invention may contain 5 to 30% by weight of the preservative composition, preferably 5 to 15% by weight, based on the total amount of the cosmetic composition.

The cosmetic composition of the present invention is not limited, but may be a lotion, emulsion, cream, essence, gel, pack, foundation, mascara, eye shadow, eyeliner, cleansing cream, foam cleansing or body wash.

The cosmetic composition of the present invention may be different depending on the use, but in addition to the preservative composition of the present invention, it may further include one or more conventional additives selected from stabilizers, emulsifiers, thickeners, liquid crystal film strengthening agents, pigments and fragrances. At this time, the additive is not limited as long as it is a raw material generally used in the art, and specific examples include fatty alcohols such as cetearyl alcohol, cetyl alcohol, and behenyl alcohol and BSPAGE 15/methylethyldimethyl silane. , dimethicone/dimethicone PEG-10/15, dimethicone/polyglycerin-3, dimethicone/dimethiconol, dimethicone/dimethicone vinyl dimethicone, cyclomethicone/dimethiconol, cyclomethicone/dimethicone Chicone, cyclomethicone/trimethylsiloxysilicate, cyclopentasilonic acid/dimethicone, cyclopentasilonic acid/PEG-12 dimethicone, cyclopentasilonic acid/cetearyl dimethicone/vinyl dimethicone, cyclopentasilonic acid a stabilizer selected from silicone polymers such as /dimethicone/vinyl dimethicone and dimethicone/vinyl dimethicone crosspolymer; An emulsifier selected from cationic surfactants, anionic surfactants, amphoteric surfactants, nonionic surfactants, etc. may be mixed, preferably polyglyceryl-4 caprylate/caprate, polyglyceryl-5 caprate Prylate/Caprate, Polyglyceryl-6 Caprylate/Caprate, Polyglyceryl-7 Caprylate/Caprate, Polyglyceryl-8 Caprylate/Caprate, Polyglyceryl-9 Caprylate /caprate, polyglyceryl-10 caprylate/caprate, polyglyceryl-4 caprate, polyglyceryl-5 caprate, polyglyceryl-6 caprate, polyglyceryl-7 caprate, polyglyceryl Lyl-8 caprate, polyglyceryl-9 caprate, polyglyceryl-10 caprate, polyglyceryl-4 laurate, polyglyceryl-5 laurate, polyglyceryl-6 laurate, polyglyceryl- 7 Laurate, Polyglyceryl-8 Laurate, Polyglyceryl-9 Laurate, Polyglyceryl-10 Laurate, Polyglyceryl-6 Cocoate, Polyglyceryl-7 Cocoate, Polyglyceryl-8 Cocoate Eight, polyglyceryl-9 cocoate, polyglyceryl-10 cocoate, polyglyceryl-11 cocoate, polyglyceryl-12 cocoate, polyglyceryl-6 myristate, polyglyceryl-7 myristate, Polyglyceryl-8 myristate, polyglyceryl-9 myristate, polyglyceryl-10 myristate, polyglyceryl-11 myristate, polyglyceryl-12 myristate, polyglyceryl-10 oleate, polyglyceryl Polyglyceryls, such as reel-11 oleate, polyglyceryl-12 oleate, polyglyceryl-10 stearate, polyglyceryl-11 stearate, polyglyceryl-12 stearate, polyglyceryl-6 behenate, etc. Of course, it is possible to directly prepare a fatty acid ester-based surfactant by reacting polyglyceryl with a fatty acid or to purchase a commercially available one. The thickener is for improving the feeling of use and formulation stability by imparting an appropriate viscosity of the cosmetic composition, and may be selected from carbomer, carbopol, gelatin, xanthan gum, natural cellulose, Hisel, methyl cellulose, etc., but is limited thereto not. The liquid crystal film strengthening agent serves to increase the strength of the liquid crystal and maintain long-term stability of the liquid crystal by closely connecting the fence, phytosphingosine, bishydroxyethyl biscetylmaloamide, cholesterol isostearate, cholesterol It may be oleate, cholesterol stearate, lecithin, ceramides (eg, ceramide 3, ceramide 6), but is not limited thereto.

In addition, the pigment includes an extender pigment, a white pigment, a colored pigment, a pearlescent pigment, a metal powder, an organic powder, and the like, and the extender pigment includes talc, mica, kaolin, calcium carbonate, mica, talc, kaolin, alumina, silicic acid. Barium, zeolite, muscovite, magnesium carbonate, barium sulfate, etc. are available. As white pigments, titanium oxide, zinc oxide, etc. are possible, and as color pigments, bengara, iron sulfate, black iron oxide, chromium oxide, ultramarine blue, royal blue, and carbon black, and the like. As the pearlescent pigment, titanium dioxide, mica titanium, iron titanate and titanium oxide-coated mica, silica, tin oxide, and ferric ferrocyanide are possible, and the metal powder includes gold, silver, Copper, palladium, platinum, etc. are possible, and as an organic powder, polymethyl methacrylate, nylon, cellulose, starch, etc. are possible. In addition, all natural, inorganic, and organic pigments commonly known in cosmetics may be used, and the natural pigments include gardenia yellow, gardenia blue, gardenia green, gardenia red, red yeast color pigment, red yeast yellow pigment, and safflower yellow pigment. , annatto pigment, cochineal pigment, rock pigment, high-capacity pigment, grape skin pigment, red cabbage pigment, elderberry pigment, blueberry pigment, puprika pigment, caramel pigment, red radish pigment, persimmon pigment, electric current pigment, riboflavin, One selected from the group consisting of beta-carotene, cacao pigment, turmeric pigment, corn red pigment, beet red pigment, anthocyanin, anthocyanin, phycocyanin, phycocyanin, chlorophyll pigment, and combinations thereof is possible. Metal oxides, especially iron oxides (red, black, yellow, brown), titanium dioxide, zinc oxide, chromium oxide, bismuth oxychloride, aluminum oxide, zirconium oxide, cobalt oxide, cerium oxide, nickel oxide, calcium hydroxide, iron hydroxide, aluminum hydroxide , chromium hydroxide, magnesium hydroxide, ferric ammonium ferrocyanide, Prussian blue, iron sulfide, manganese violet, carbon black, mica, kaolin, and one selected from the group consisting of combinations thereof is possible, and the organic pigment includes indigo lake, Carmine Lake, lakes from the well-known FD&C and D&C dye series, such as D&C Red 21 aluminum lake, D&C Red 7 calcium lake, aromatic azo, indigoid, triphenylmethane, anthraquinone and xanthine dyes, natural or synthetic. Organic dyes and the like can be used.

The additive according to an embodiment of the present invention is preferably not more than 15% by weight based on 100% by weight of the total cosmetic composition.

The cosmetic composition of the present invention contains ethanol and a C1-C5 polyol, preferably a C3-C4 polyol, so that the C1-C5 polyol acts as a preservative and a moisturizer, thereby eliminating the need to use a separate moisturizer.

Hereinafter, the present invention will be described in detail in the following specific examples, but the specific examples of the present invention are only examples for describing the present invention in detail, and do not limit the scope of the present invention.

[Examples 1 to 18 and Comparative Examples 1 to 12] Preparation of preservative composition

100 ml of the preservative compositions of Examples 1 to 18 and Comparative Examples 1 to 12 were prepared by dissolving ethanol and polyol in distilled water with the composition shown in Table 1 below.

In order to evaluate the antiseptic power of the prepared antiseptic composition, a mixed bacterial solution of P. aeruginosa , E. coli , S. aureus was mixed to an initial concentration of 10 ⁶ cfu/ml per sample, and then stored in a thermostat at 25° C. after 7 days The number of viable cells was measured, and Candida albicans and Aspergillus brazilians were used as yeast and mold as yeast and mold, respectively, treated in the same manner as bacterial bacteria, and the number of viable cells was measured after 14 days. indicated.

polyol type Polyol content (wt%) Ethanol content (wt%) Day 7 Day 14 bacteria yeast mold Example 1 glycerin 5 3 > 0 > 0 > 0 Example 2 glycerin 5 5 > 2 > 0 > 1 Comparative Example 1 glycerin 5 - > 0 > 0 > 0 Example 3 glycerin 7 3 > 0 > 0 > 1 Example 4 glycerin 7 5 > 3 > 0 > 0 Comparative Example 2 glycerin 7 - > 0 > 0 > 1 Example 5 glycerin 10 3 > 1 > 0 > 0 Example 6 glycerin 10 5 > 3 > 0 > 0 Comparative Example 3 glycerin 10 - > 0 > 0 > 1 Example 7 1,3-butanediol 5 3 > 1 > 0 > 0 Example 8 1,3-butanediol 5 5 > 3 > 0 > 1 Comparative Example 4 1,3-butanediol 5 - > 0 > 0 > 1 Example 9 1,3-butanediol 7 3 > 2 > 0 > 1 Example 10 1,3-butanediol 7 5 > 3 > 2 > 0 Comparative Example 5 1,3-butanediol 7 - > 0 > 0 > 1 Example 11 1,3-butanediol 10 3 > 2 > 1 > 1 Example 12 1,3-butanediol 10 5 > 3 > 3 > 0 Comparative Example 6 1,3-butanediol 10 - > 1 <1 > 0 Example 13 1,3-propanediol 5 3 > 3 > 0 > 0 Example 14 1,3-propanediol 5 5 > 3 > 0 > 0 Comparative Example 7 1,3-propanediol 5 - > 3 > 0 > 0 Example 15 1,3-propanediol 7 3 > 3 > 0 > 0 Example 16 1,3-propanediol 7 5 > 3 > 1 > 1 Comparative Example 8 1,3-propanediol 7 - > 3 > 0 > 1 Example 17 1,3-propanediol 10 3 > 3 > 0 > 1 Example 18 1,3-propanediol 10 5 > 3 > 2 > 1 Comparative Example 9 1,3-propanediol 10 - > 3 > 0 > 1 Comparative Example 10 - - 5 > 0 > 0 > 0 Comparative Example 11 - - 7 > 0 > 0 > 0 Comparative Example 12 - 10 > 0 > 0 > 0

Log reduction is the log value at which the initial number of load bacteria decreases.

As shown in Comparative Examples 1 to 9 of Table 1, when only polyol was treated, there was no preservative effect even at 10% by weight, and as shown in Comparative Examples 10 to 12, even when only ethanol was treated, there was no preservative effect. .

However, it can be seen that when treated with a combination of ethanol and polyol, a surprising antiseptic effect is shown.

That is, the preservative composition of the present invention contains a combination of ethanol and a C1-C5 polyol as an antiseptic component, thereby ISO preservative power passing standard (ISO 11930 preservative efficacy test method pass standard - Bacteria 7th day 3 log or more, Yeast 14th day It has an amazing antiseptic effect that satisfies 1 log or more, 0 log or more on the 14th day of the mold).

[Example 19] Preparation of a cosmetic composition containing a preservative composition

A cosmetic composition containing the preservative composition of the present invention was prepared with the composition shown in Table 2 below, and the preservative force evaluation performed in Examples 1 to 18 was performed in the same manner as in Examples 1 to 18, except that the prepared cosmetic composition was used. The preservative power of the cosmetic composition was evaluated, and the results are shown in Table 3.

Display name (Korean) Display name (English) Content (wt%) Purified water WATER Remaining amount (To 100) Butylene Glycol BUTYLENE GLYCOL 7.0000000 squalane SQUALANE 4.0000000 ethanol ETHANOL 3.0000000 Cyclopentasiloxane CYCLOPENTASILOXANE 2.2200000 Dimethicone/Vinyl Dimethicone Crosspolymer DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER 1.8900000 Cetylethylhexanoate CETYL ETHYLHEXANOATE 1.5 million Cyclohexasiloxane CYCLOHEXASILOXANE 1.0800000 C12-14Pares-12 C12-14 PARETH-12 0.0045000 C12-20 alkyl glucoside C12-20 ALKYL GLUCOSIDE 0.2000000 C14-22 alcohol C14-22 ALCOHOLS 0.8000000 Glyceryl Stearate GLYCERYL STEARATE 0.5000000 Glyceryl Caprylate GLYCERYL CAPRYLATE 0.1010000 dimethicone DIMETHICONE 1.0000000 Dimethiconol DIMETHICONOL 0.2000000 Disodium EDIT DISODIUM EDTA 0.0500000 horse chestnut extract AESCULUS HIPPOCASTANUM (HORSE CHESTNUT) SEED EXTRACT 0.0010000 mannitol MANNITOL 0.0750000 behenyl alcohol BEHENYL ALCOHOL 0.3000000 cetearyl alcohol CETEARYL ALCOHOL 0.6000000 Centauri Extract CENTAURIUM ERYTHRAEA EXTRACT 0.0100000 shea butter BUTYROSPERMUM PARKII (SHEA) BUTTER 1.0000000 Ammonium glycyrrhizate AMMONIUM GLYCYRRHIZATE 0.0200000 Spices FRAGRANCE 0.1500000

polyol type
Polyol content (wt%)
Ethanol content (wt%)
Day 7 Day 14
bacteria yeast mold Example 19 Butylene Glycol 5 5 3 > 3 > 1 > 1

As shown in Table 3, the cosmetic composition of the present invention has a significant antiseptic effect against each yeast, bacteria and mold without including a separate preservative component, and at the same time has very low skin irritation.

Claims (8)

Preservative composition for E. coli, P. aeruginosa, S. aureus, or a mixture thereof, comprising ethanol and C1-C5 polyol in a weight ratio of 1:1 to 1:10. The method of claim 1,
The polyol is a preservative composition having 3 to 4 carbon atoms. The method of claim 1,
The polyol is one or two or more preservatives selected from glycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, 1,3-propanediol and butylene glycol. The method of claim 1,
wherein the polyol is glycerin, 1.3-butanediol or 1,3-propanediol. A cosmetic composition comprising the preservative composition of any one of claims 1 to 4. 6. The method of claim 5,
The preservative composition is a cosmetic composition comprising 5 to 30% by weight based on the total amount of the cosmetic composition. 6. The method of claim 5,
The cosmetic composition further comprises squalane.
8. The method of claim 7,
The squalane is included in an amount less than the polyol, and is included in an amount greater than that of the ethanol.