KR102413754B1 - 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염 - Google Patents

이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염 Download PDF

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KR102413754B1
KR102413754B1 KR1020227008412A KR20227008412A KR102413754B1 KR 102413754 B1 KR102413754 B1 KR 102413754B1 KR 1020227008412 A KR1020227008412 A KR 1020227008412A KR 20227008412 A KR20227008412 A KR 20227008412A KR 102413754 B1 KR102413754 B1 KR 102413754B1
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leucine
acetyl
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treatment
pharmaceutically acceptable
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KR20220038814A (ko
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말로리 팩터
마이클 스트럽
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인트라바이오 리미티드
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
KR1020227008412A 2016-04-19 2017-04-19 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염 Active KR102413754B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227021015A KR102632670B1 (ko) 2016-04-19 2017-04-19 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB201606834 2016-04-19
GB1606834.8 2016-04-19
KR1020187032983A KR20180134398A (ko) 2016-04-19 2017-04-19 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염
PCT/GB2017/051090 WO2017182802A1 (en) 2016-04-19 2017-04-19 Acetyl-leucine or a pharmaceutically acceptable salt thereof for improved mobility and cognitive function

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KR1020187032983A Division KR20180134398A (ko) 2016-04-19 2017-04-19 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염

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KR1020227021015A Division KR102632670B1 (ko) 2016-04-19 2017-04-19 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염

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KR20220038814A KR20220038814A (ko) 2022-03-29
KR102413754B1 true KR102413754B1 (ko) 2022-06-27

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KR1020247003393A Active KR102791288B1 (ko) 2016-04-19 2017-04-19 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염
KR1020187032983A Ceased KR20180134398A (ko) 2016-04-19 2017-04-19 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염
KR1020227008412A Active KR102413754B1 (ko) 2016-04-19 2017-04-19 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염
KR1020227021015A Active KR102632670B1 (ko) 2016-04-19 2017-04-19 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염

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KR1020247003393A Active KR102791288B1 (ko) 2016-04-19 2017-04-19 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염
KR1020187032983A Ceased KR20180134398A (ko) 2016-04-19 2017-04-19 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염

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KR1020227021015A Active KR102632670B1 (ko) 2016-04-19 2017-04-19 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염

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US (4) US10905670B2 (OSRAM)
EP (2) EP3445351B1 (OSRAM)
JP (3) JP7387264B2 (OSRAM)
KR (4) KR102791288B1 (OSRAM)
CN (2) CN118593463A (OSRAM)
AU (2) AU2017252507B2 (OSRAM)
BR (1) BR112018071547A2 (OSRAM)
CA (1) CA3021155A1 (OSRAM)
DK (1) DK3445351T3 (OSRAM)
ES (1) ES2994242T3 (OSRAM)
FI (1) FI3445351T3 (OSRAM)
HR (1) HRP20241552T1 (OSRAM)
HU (1) HUE069219T2 (OSRAM)
IL (3) IL293266B2 (OSRAM)
LT (1) LT3445351T (OSRAM)
MD (1) MD3445351T2 (OSRAM)
MX (2) MX388461B (OSRAM)
NZ (1) NZ747307A (OSRAM)
PL (1) PL3445351T3 (OSRAM)
PT (1) PT3445351T (OSRAM)
RS (1) RS66142B1 (OSRAM)
RU (1) RU2745912C2 (OSRAM)
SG (2) SG11201809031XA (OSRAM)
SI (1) SI3445351T1 (OSRAM)
SM (1) SMT202400459T1 (OSRAM)
WO (1) WO2017182802A1 (OSRAM)
ZA (1) ZA201806849B (OSRAM)

Families Citing this family (7)

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KR102791288B1 (ko) * 2016-04-19 2025-04-03 인트라바이오 리미티드 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염
AU2017308865B2 (en) 2016-08-11 2023-04-13 Intrabio Limited Therapeutic agents for neurodegenerative diseases
GB201709459D0 (en) 2017-06-14 2017-07-26 Intrabio Ltd Treatment for migraine
JP7471298B2 (ja) 2018-12-06 2024-04-19 イントラビオ エルティーディー アセチル-ロイシンの重水素化類似体
SI3934637T1 (sl) * 2019-03-02 2024-10-30 Intrabio Ltd Summit House (N-)acetil-L-levcin za uporabo pri zdravljenju travmatske poškodbe možganov
US12171852B1 (en) 2023-07-18 2024-12-24 Sytheon Ltd Composition and methods for regulating melanogenesis
US12403111B2 (en) 2024-02-02 2025-09-02 SynGAP Research Fund Compositions and methods for treating neurodevelopmental disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060063827A1 (en) * 2004-09-23 2006-03-23 Yu Ruey J Systemic administration of therapeutic amino acids and N-acetylamino acids
US20070190070A1 (en) * 2004-09-03 2007-08-16 Zeldis Jerome B Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
FR2883180B1 (fr) * 2005-03-18 2007-05-25 Pierre Fabre Medicament Sa Utilisation de l'acetyl-leucine pour la preparation d'un medicament destine au traitement de troubles de l'equilibre
FR2905600B1 (fr) * 2006-09-13 2010-01-15 Pf Medicament Traitement des vertiges par l'acetyl-l-leucine.
US20080097606A1 (en) * 2006-10-19 2008-04-24 Cragg Andrew H Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis
EP2152280A1 (en) * 2007-05-08 2010-02-17 Northern Innovations And Formulations Corp. Branched-chain amino acid composition for improving skeletal muscle protein metabolism
US20120196257A1 (en) * 2009-08-27 2012-08-02 Joe Verghese Cognitive function training to improve motor ability
TN2010000251A1 (fr) * 2010-06-03 2011-11-11 Rekik Raouf N-acetyl-dl-leucine medicament neuro et retino protecteur
WO2012060844A1 (en) * 2010-11-05 2012-05-10 Biotie Therapies, Inc A2a antagonists as cognition and motor function enhancers
TN2010000566A1 (en) * 2010-12-03 2012-05-24 Rekik Raouf Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs
KR102791288B1 (ko) 2016-04-19 2025-04-03 인트라바이오 리미티드 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염
WO2019079536A1 (en) * 2017-10-18 2019-04-25 Intrabio Ltd THERAPEUTIC AGENTS FOR IMPROVED MOBILITY AND COGNITIVE FUNCTION AND FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES AND LYSOSOMAL STORAGE DISORDERS

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Aging and Disease, 6(1), 38-47, 2015.
European Journal of Pharmacology, 769, 342-349, 2015.
Journal of Neurology, 260(10), 2556-2561, 2013.
Neurology, 85(16), 1368-1375, 2015.

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Publication number Publication date
JP2019513814A (ja) 2019-05-30
LT3445351T (lt) 2024-11-25
AU2022256077A1 (en) 2022-11-17
EP3445351A1 (en) 2019-02-27
KR20240018683A (ko) 2024-02-13
FI3445351T3 (fi) 2024-11-18
MX2018012739A (es) 2019-06-17
KR20180134398A (ko) 2018-12-18
MD3445351T2 (ro) 2024-12-31
AU2017252507B2 (en) 2022-07-21
ES2994242T3 (en) 2025-02-05
HRP20241552T1 (hr) 2025-01-17
JP2022024058A (ja) 2022-02-08
EP3445351B1 (en) 2024-10-16
CN109069463B (zh) 2024-07-23
IL293266A (en) 2022-07-01
NZ747307A (en) 2025-10-31
US12329733B2 (en) 2025-06-17
EP4501406A3 (en) 2025-03-26
IL293266B1 (en) 2024-03-01
ZA201806849B (en) 2019-07-31
IL262379B (en) 2022-07-01
BR112018071547A2 (pt) 2019-03-06
JP2024123087A (ja) 2024-09-10
CA3021155A1 (en) 2017-10-26
WO2017182802A1 (en) 2017-10-26
KR20220093386A (ko) 2022-07-05
RU2745912C2 (ru) 2021-04-02
KR20220038814A (ko) 2022-03-29
US20250332133A1 (en) 2025-10-30
CN118593463A (zh) 2024-09-06
AU2017252507A1 (en) 2018-11-08
IL293266B2 (en) 2024-07-01
SG10202106190RA (en) 2021-07-29
JP7387264B2 (ja) 2023-11-28
MX388461B (es) 2025-03-20
PT3445351T (pt) 2024-11-14
SMT202400459T1 (it) 2025-01-14
KR102791288B1 (ko) 2025-04-03
IL262379A (en) 2018-11-29
IL310508A (en) 2024-03-01
RU2018140131A (ru) 2020-05-14
KR102632670B1 (ko) 2024-02-01
SI3445351T1 (sl) 2025-04-30
HUE069219T2 (hu) 2025-02-28
EP4501406A2 (en) 2025-02-05
US20190083438A1 (en) 2019-03-21
US10905670B2 (en) 2021-02-02
DK3445351T3 (da) 2024-11-04
US20230346732A1 (en) 2023-11-02
US11998518B2 (en) 2024-06-04
MX2021014844A (es) 2022-01-18
JP7506046B2 (ja) 2024-06-25
RS66142B1 (sr) 2024-12-31
PL3445351T3 (pl) 2025-01-07
US20210106548A1 (en) 2021-04-15
CN109069463A (zh) 2018-12-21
SG11201809031XA (en) 2018-11-29
RU2021107001A (ru) 2021-04-12
RU2018140131A3 (OSRAM) 2020-05-14

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