KR102373348B1 - Composition for Anti-obesity Using an Extract of Persicaria lapathifolia - Google Patents
Composition for Anti-obesity Using an Extract of Persicaria lapathifolia Download PDFInfo
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- KR102373348B1 KR102373348B1 KR1020190170702A KR20190170702A KR102373348B1 KR 102373348 B1 KR102373348 B1 KR 102373348B1 KR 1020190170702 A KR1020190170702 A KR 1020190170702A KR 20190170702 A KR20190170702 A KR 20190170702A KR 102373348 B1 KR102373348 B1 KR 102373348B1
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
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- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
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Abstract
본 발명은, 마우스 전구지방세포인 3T3-L1의 지방세포로의 분화, 지방 축적을 뚜렷하게 억제하는 활성을 가진 흰여뀌 추출물을 이용한 항비만용 조성물을 개시한다.
The present invention discloses a composition for anti-obesity using an extract of white lichen, which has the activity of remarkably inhibiting the differentiation of 3T3-L1 mouse precursor adipocytes into adipocytes and the accumulation of fat.
Description
본 발명은 흰여뀌(Persicaria lapathifolia) 추출물을 이용한 항비만용 조성물에 관한 것이다.The present invention relates to a composition for anti-obesity using an extract of white yew ( Persicaria lapathifolia ).
현대사회는 급속한 자동화에 따른 편리한 생활환경, 가공식품 및 외식의 증가에 따른 과다 영양 섭취 및 신체활동량의 감소로 인해 비만인구가 증가하고 있다. 세계보건기구(WHO)는 비만을 하나의 현상이나 증상이 아닌 질병으로 분류하고 있으며, 2015년에는 전세계 비만인구가 15억 명으로 증가하여 중대한 건강상의 문제가 될 것이라고 보고한 바 있다(Ann Epidemiol. 2005. 15:87-97; J Life Sci. 2013. 23:69-78). 비만의 원인은 명확하게 밝혀져 있지 않지만 단일조건에 의해 발생하는 것이 아니라 부적절한 식생활 및 생활습관, 유전적 요인, 신체 활동의 감소 등의 다양한 원인에 의해 발생한다(.Korean J. Food Science Nutrition 22(1)110-12.2009;Korean J. Food Science Nutrition 23(5):363-367.1990).In modern society, the obese population is increasing due to the convenient living environment according to the rapid automation, the excessive nutritional intake and the decrease in the amount of physical activity due to the increase in processed food and eating out. The World Health Organization (WHO) classifies obesity as a disease rather than a phenomenon or symptom, and reported that in 2015, the number of obese people worldwide will increase to 1.5 billion and become a serious health problem (Ann Epidemiol. 2005. 15:87-97; J Life Sci. 2013. 23:69-78). Although the cause of obesity is not clearly known, it is not caused by a single condition, but is caused by various causes such as improper diet and lifestyle, genetic factors, and decrease in physical activity (.Korean J. Food Science Nutrition 22(1) ) 110-12.2009; Korean J. Food Science Nutrition 23(5):363-367.1990).
비만은 에너지 섭취와 소비간의 불균형으로 인해 과도하게 체지방이 축적되어 지방세포의 수와 크기가 증가하는 것으로(Cell.104:531-543 2001), 체내 에너지는 지방세포에 중성지방(triglyceride) 형태로 저장되었다가 에너지원이 고갈되면 저장되었던 지방이 유리지방산과 글리세롤로 분해되어 에너지원으로 사용되게 되지만, 에너지의 과잉 섭취는 지방세포의 분화를 촉진하고 체내 저장 지방량을 증가시켜 비만의 직접적인 원인이 된다(Metabolism. 30: 425-427 1981; Biochem J. 1;435(3):723-32 2011). 비만은 내장과 복부의 지방축적에 따른 체형의 변화뿐만 아니라 각종 질환의 발병률을 증가시키는 위험요소로 작용한다(Korean J. Pediatr.48:126-137. 2005) 내장지방이 과도하게 쌓이게 되면 체내 당 대사에 문제가 생기게 되며, 호르몬 분비 이상, 사이토카인 분비 이상 등의 증상이 발생하게 된다. 비만으로 인해 중성지방과 LDL-콜레스테롤의 증가, HDL-콜레스테롤의 감소는 체내 지방대사이상을 가져오고, 조직에 존재하는 인슐린 수용체를 감소시키며, 인슐린 민감도 또한 감소시켜 세포 내로 이동되는 포도당의 운반이 억제되면서 고혈당, 당뇨병을 유발하기도 한다. 또한 비만은 고지혈증, 심혈관계 질환, 암, 호흡기 장애, 뇌졸중, 골관절염(osteoarthritis)등의 대사질환의 발생과 관계가 깊은 것으로 알려져 있다(Med. Int. 22 385-388 1994;.Ann. Intern. Med. 103:1024-1029 1985).Obesity is an increase in the number and size of fat cells due to excessive accumulation of body fat due to an imbalance between energy intake and consumption (Cell.104:531-543 2001). When the energy source is depleted after being stored, the stored fat is decomposed into free fatty acids and glycerol to be used as an energy source. (Metabolism. 30: 425-427 1981; Biochem J. 1;435(3):723-32 2011). Obesity acts as a risk factor that increases the incidence of various diseases as well as changes in body type due to the accumulation of fat in the intestines and abdomen (Korean J. Pediatr.48:126-137. 2005) When visceral fat accumulates excessively, Problems arise in metabolism, and symptoms such as abnormal secretion of hormones and abnormal secretion of cytokines occur. Due to obesity, an increase in triglyceride and LDL-cholesterol and a decrease in HDL-cholesterol lead to abnormal fat metabolism in the body, decrease insulin receptors in tissues, and also decrease insulin sensitivity, thereby inhibiting the transport of glucose into cells. It can also lead to high blood sugar and diabetes. Also, obesity is known to be closely related to the occurrence of metabolic diseases such as hyperlipidemia, cardiovascular disease, cancer, respiratory disorders, stroke, and osteoarthritis (Med. Int. 22 385-388 1994;. Ann. Intern. Med 103:1024-1029 1985).
지방세포의 생리작용 조절은 크게 지방세포의 분화 유도, 지방 생합성, 지질 분해로 나눌 수 있다. 지방세포의 분화 단계에서는 PPAR(peroxisome proliferatoractivated receptor), C/EBP(CCAAT/enhancerbinding proteins), SREBP(sterol regulatory element binding protein)등의 다양한 전사인자들이 분화가 진행 중인 지방세포에서 단계별로 발현이 유도되며, 각 인자들의 상호작용을 통해 다양한 지방세포 특이 유전자의 발현을 조절하게 된다(Genes Dev. 14:1293-1307. 2000). 분화가 완료된 지방세포는 내부로 유입된 지방산과 포도당을 이용하여 중성지방 생합성이 일어나는데, 이에 관여하는 효소들은 FAS(fatty acid synthase), ACC(acetyl-CoA carboxylase), SCD(stearoyl-CoAdesaturase), ACS(acyl-CoA synthetase), DGAT(diacylglycerol acyltransferase)등이 있다(Trends Endocrinol. Metab., 23, 56-64. 2011; Biochem. Biophys. Res. Commun., 420,805-810. 2012). 이러한 효소들의 작용에 의해 합성된 중성지방은 에너지원으로 사용된다. 지질 분해는 영양상태에 따라 카테콜아민과 인슐린에 의해서 조절된다. 지질 분해에 관여하는 효소는 ATGL(adipose triglyceride lipase), HSL(hormone sensitive lipase), MGL(monoacyl glycerol lipase) 등이 있으며, 이러한 효소의 작용으로 한 분자의 중성지방이 가수분해되면 글리세롤 한 분자와 지방산 세 분자로 나누어진다(Trends Endocrinol. Metab., 23, 56-64. 2011; Biochem. Biophys. Res. Commun., 420,805-810. 2012). 가수분해되어 생성된 지방산은 미토콘드리아에서 산화되어 에너지로 소모되거나 에스테르화되어 중성지방으로 합성되어 세포에 저장된다.Physiological regulation of adipocytes can be largely divided into induction of adipocyte differentiation, fat biosynthesis, and lipid degradation. During the differentiation stage of adipocytes, expression of various transcription factors such as peroxisome proliferatoractivated receptor (PPAR), CCAAT/enhancer binding proteins (C/EBP), and sterol regulatory element binding protein (SREBP) is induced step by step in adipocytes undergoing differentiation. , regulates the expression of various adipocyte-specific genes through the interaction of each factor (Genes Dev. 14:1293-1307. 2000). Adipocytes that have completed differentiation undergo triglyceride biosynthesis using the fatty acids and glucose introduced into them. The enzymes involved in this are FAS (fatty acid synthase), ACC (acetyl-CoA carboxylase), SCD (stearoyl-CoAdesaturase), and ACS. (acyl-CoA synthetase), DGAT (diacylglycerol acyltransferase), and the like (Trends Endocrinol. Metab., 23, 56-64. 2011; Biochem. Biophys. Res. Commun., 420,805-810. 2012). The triglyceride synthesized by the action of these enzymes is used as an energy source. Lipid degradation is regulated by catecholamines and insulin according to nutritional status. Enzymes involved in lipid degradation include ATGL (adipose triglyceride lipase), HSL (hormone sensitive lipase), and MGL (monoacyl glycerol lipase). It is divided into three molecules (Trends Endocrinol. Metab., 23, 56-64. 2011; Biochem. Biophys. Res. Commun., 420,805-810. 2012). Fatty acids produced by hydrolysis are oxidized in mitochondria and consumed as energy or esterified and synthesized as triglycerides and stored in cells.
지방지방세포인 3T3-L1은 Green과 Meuth에 의해 처음으로 3T3 세포로부터 분리되었고(Cell. 3(2):127-33. 1974), 생물학적 특성과 적절한 배양 조건으로 지방세포로 분화하는 성질이 밝혀진 후 지방세포의 분화과정과 축적된 지방의 분해에 대한 연구를 수행하는데 널리 이용되고 있다. 지방전구세포인 3T3-L1 세포는 다양한 호르몬 및 PPAR, C/EBP, SREBP에 의해 성숙 지방세포로 분화되면서 관련 유전자의 발현과 관련 효소 활성의 증가로 세포 내 중성지방을 축적하게 된다(J Nutr 130: 3116S-3121S, 2000; J Nutr 130: 3122S-3126S, 2000). 기능성 소재 개발 연구를 위해서 지방조직 내의 중성지방의 과도한 축적 저해를 목표로 위와 같은 3T3-L1 세포를 이용하여 분화 과정을 억제하거나 지방 분해를 촉진하는 소재를 탐색하는 방법이 널리 사용되고 있다. 3T3-L1 adipocytes were first isolated from 3T3 cells by Green and Meuth (Cell. 3(2): 127-33. 1974), and their biological properties and the ability to differentiate into adipocytes under appropriate culture conditions were revealed. It is widely used to conduct research on the differentiation process of post-adipocytes and the decomposition of accumulated fat. 3T3-L1 cells, which are preadipocytes, are differentiated into mature adipocytes by various hormones, PPAR, C/EBP, and SREBP, and accumulate intracellular triglycerides due to increased expression of related genes and related enzyme activity ( J Nutr 130: 3116S-3121S, 2000; J Nutr 130: 3122S-3126S, 2000). For functional material development research, a method of searching for materials that inhibit the differentiation process or promote lipolysis using 3T3-L1 cells as described above with the aim of inhibiting excessive accumulation of triglycerides in adipose tissue is widely used.
기존의 오르리스타트(orlistat)과 시부트라민(sibutramin) 등의 항비만 약물은 구토, 변비, 위장장애, 심혈관 질환 등 심각한 부작용을 지닌 것으로 알려졌기 때문에(Int J Obes Relat Metab Disord. Jul;25(7):1095-9. 2001; Obes Res. 8(6):431-7. 2000; Lancet. 6;369(9555):71-7. 2007;Front Physiol. 2014 Jun 24;5:228. 2014), 효과적이고 안전한 물질 개발 노력이 지속되고 있다. 레티놀, 비타민 E, 비타민 U, 산초나무 추출물 등이 지방 세포 분화를 억제 기능을 하는 물질로써 보고된 바 있으며(Mol Cell Biol. 16:15671575. 1996;Ann Dermatol. Feb;24(1):39-44 2012; J Nutr. 139(1):51-7 2009; Ann Dermatol. 24(1):39-44 2012) 안전하고 지속적인 섭취가 가능한 천연물질 소재의 항비만제 개발 연구가 활발하게 이루어지고 있다. Existing anti-obesity drugs such as orlistat and sibutramine are known to have serious side effects, such as vomiting, constipation, gastrointestinal disorders, and cardiovascular disease (Int J Obes Relat Metab Disord. Jul;25(7)). :1095-9. 2001; Obes Res. 8(6):431-7. 2000; Lancet. 6;369(9555):71-7. 2007;Front Physiol. 2014 Jun 24;5:228. 2014); Efforts to develop effective and safe substances are ongoing. It has been reported that retinol, vitamin E, vitamin U, and extracts of cypress tree extract have a function of inhibiting the differentiation of adipocytes (Mol Cell Biol. 16:15671575. 1996; Ann Dermatol. Feb;24(1):39- 44 2012; J Nutr. 139(1):51-7 2009; Ann Dermatol. 24(1):39-44 2012) Research on the development of safe and sustainable natural substances for anti-obesity drugs is being actively conducted. .
본 발명은 흰여뀌 추출물의 항비만 용도를 개시한다. The present invention discloses the anti-obesity use of the extract
본 발명의 목적은 흰여뀌 추출물을 이용한 항비만용 조성물을 제공하는 데 있다.It is an object of the present invention to provide a composition for anti-obesity using the extract
본 발명의 다른 목적이나 구체적인 목적은 이하에서 제시될 것이다. Other objects or specific objects of the present invention will be set forth below.
본 발명은 아래의 실시예 및 실험예에서 확인되는 바와 같이, 흰여뀌 추출물이 마우스 전구지방세포인 3T3-L1의 지방세포로의 분화와 지방 축적을 뚜렷하게 억제함을 확인함으로써 완성된 것이다. As confirmed in the Examples and Experimental Examples below, the present invention has been completed by confirming that the extract of white lichen remarkably inhibits the differentiation of 3T3-L1 mouse precursor adipocytes into adipocytes and the accumulation of fat.
전술한 바의 실험 결과를 고려할 때, 본 발명의 항비만용 조성물은 흰여뀌 추출물을 그 유효성분으로 포함함을 특징으로 한다.Considering the experimental results of the above bar, the composition for anti-obesity of the present invention is characterized in that it contains the extract of white fern extract as an active ingredient.
본 명세서에서, "흰여뀌 추출물"이란 추출 대상인 흰여뀌 잎, 줄기, 지상부, 근경, 뿌리, 지하부, 전초 또는 이들의 혼합물을 물, 탄소수 1 내지 4의 저급 알콜(메탄올, 에탄올, 부탄올 등), 메틸렌클로라이드, 에틸렌, 아세톤, 헥산, 에테르, 클로로포름, 에틸아세테이트, 부틸아세테이트, N,N-디메틸포름아미드(DMF), 디메틸설폭사이드(DMSO), 1,3-부틸렌글리콜, 프로필렌글리콜 또는 이들의 혼합 용매를 사용하여 침출하여 얻어진 추출물, 이산화탄소, 펜탄 등 초임계 추출 용매를 사용하여 얻어진 추출물 또는 그 추출물을 분획하여 얻어진 분획물을 의미하며, 추출 방법은 활성물질의 극성, 추출 정도, 보존 정도를 고려하여 냉침, 환류, 가온, 초음파 방사, 초임계 추출 등 임의의 방법을 적용할 수 있다. 분획된 추출물의 경우 추출물을 특정 용매에 현탁시킨 후 극성이 다른 용매와 혼합·정치시켜 얻은 분획물, 상기 조추출물을 실리카겔 등이 충진된 칼럼에 흡착시킨 후 소수성 용매, 친수성 용매 또는 이들의 혼합 용매를 이동상으로 하여 얻은 분획물을 포함하는 의미이다. 또한 상기 추출물의 의미에는 동결건조, 진공건조, 열풍건조, 분무건조 등의 방식으로 추출 용매가 제거된 농축된 액상의 추출물 또는 고형상의 추출물이 포함된다. 바람직하게는 추출용매로서 물, 탄소수 1 내지 4의 알콜 또는 이들의 혼합 용매를 사용하여 얻어진 추출물, 더 바람직하게는 추출용매로서 물과 탄소수 1 내지 4의 알콜의 혼합 용매를 사용하여 얻어진 추출물을 의미한다.In the present specification, the term "Hiphorus extract" refers to extracts of leaves, stems, above-ground parts, rhizomes, roots, underground parts, outposts, or mixtures thereof with water, lower alcohols having 1 to 4 carbon atoms (methanol, ethanol, butanol, etc.), methylene chloride , ethylene, acetone, hexane, ether, chloroform, ethyl acetate, butyl acetate, N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), 1,3-butylene glycol, propylene glycol, or a mixed solvent thereof means an extract obtained by leaching using , an extract obtained by using a supercritical extraction solvent such as carbon dioxide or pentane, or a fraction obtained by fractionating the extract. , reflux, warming, ultrasonic radiation, supercritical extraction, and the like can be applied any method. In the case of the fractionated extract, a fraction obtained by suspending the extract in a specific solvent and mixing and standing still with a solvent having a different polarity, and adsorbing the crude extract to a column filled with silica gel, etc. It is meant to include the fraction obtained as a mobile phase. In addition, the meaning of the extract includes a concentrated liquid extract or solid extract from which the extraction solvent has been removed by methods such as freeze drying, vacuum drying, hot air drying, spray drying, and the like. Preferably, an extract obtained by using water, an alcohol having 1 to 4 carbon atoms or a mixed solvent thereof as an extraction solvent, more preferably an extract obtained by using a mixed solvent of water and an alcohol having 1 to 4 carbon atoms as an extraction solvent do.
또 본 명세서에서 "유효성분"이란 단독으로 목적하는 활성을 나타내거나 또는 그 자체는 활성이 없는 담체와 함께 활성을 나타낼 수 있는 성분을 의미한다.In addition, as used herein, the term "active ingredient" refers to a component that alone exhibits the desired activity or can exhibit activity together with a carrier that has no activity by itself.
또 본 명세서에서, "항비만"이란 체지방의 감소, 체지방 축적 억제, 및/또는 체중의 감소를 의미한다. 따라서 비만의 예방, 비만의 치료를 포함하는 의미이며, 나아가 체중이 비만이나 과체중으로 분류되지 않지만 미용이나 건강 목적으로(일명 다이어트 목적으로) 체중/체지방을 감소시키는 것을 포함한다.Also, in the present specification, "anti-obesity" means a reduction in body fat, inhibition of body fat accumulation, and/or a reduction in body weight. Therefore, it is meant to include the prevention of obesity and the treatment of obesity, and further includes reducing body weight/body fat for beauty or health purposes (so-called diet purposes), although the weight is not classified as obese or overweight.
또한 본 명세서에서, 상기 "비만"이란, 그것이 유전적 요인에 의한 비만이든 또는 환경적 요인에 의한 비만이든 지방조직이 비정상적으로 증가된 상태를 의미하며, 체질량지수(BMI)의 구분에 따를 때는 고도 비만(BMI이 30.0 이상인 경우)과 비만(BMI 25~30인 경우) 그리고 과체중(BMI이 23~25인 경우)을 포함하는 의미이다. In addition, in the present specification, the "obesity" means a state in which adipose tissue is abnormally increased whether it is obesity due to genetic factors or obesity due to environmental factors, and according to the classification of body mass index (BMI), high It is meant to include obesity (when BMI is 30.0 or higher), obesity (when BMI is 25-30), and overweight (when BMI is 23-25).
본 발명의 항비만용 조성물은 그 유효성분을 항비만 활성을 나타낼 수 있는 한, 용도, 제형, 배합 목적 등에 따라 임의의 양(유효량)으로 포함될 수 있는데, 통상적인 유효량은 조성물 전체 중량을 기준으로 할 때 0.001 중량 % 내지 20.0 중량 % 범위 내에서 결정될 것이다. 여기서 "유효량"이란 그 적용 대상인 포유동물 바람직하게는 사람에게 의료 전문가 등의 제언에 의한 투여 기간 동안 본 발명의 조성물이 투여될 때, 항비만 효과 등 의도한 기능적·약리학적 효과를 나타낼 수 있는, 본 발명의 조성물에 포함되는 유효성분의 양을 말한다. 이러한 유효량은 당업자의 통상의 능력 범위 내에서 실험적으로 결정될 수 있다. The composition for anti-obesity of the present invention may be included in any amount (effective amount) depending on the use, formulation, purpose of blending, etc., as long as the active ingredient can exhibit anti-obesity activity, and a typical effective amount is based on the total weight of the composition. when determined within the range of 0.001 wt % to 20.0 wt %. As used herein, the term "effective amount" refers to the intended functional and pharmacological effects such as anti-obesity effects when the composition of the present invention is administered to a mammal, preferably a human subject to the application, during the administration period as suggested by a medical professional. Refers to the amount of the active ingredient contained in the composition of the present invention. Such an effective amount can be determined empirically within the ordinary ability of one of ordinary skill in the art.
본 발명의 항비만용 조성물은 그 유효성분을 항비만 활성을 나타낼 수 있는 한, 용도, 제형, 배합 목적 등에 따라 임의의 양(유효량)으로 포함될 수 있는데, 통상적인 유효량은 조성물 전체 중량을 기준으로 할 때 0.001 중량 % 내지 20.0 중량 % 범위 내에서 결정될 것이다. 여기서 "유효량"이란 그 적용 대상인 포유동물 바람직하게는 사람에게 의료 전문가 등의 제언에 의한 투여 기간 동안 본 발명의 조성물이 투여될 때, 항비만 효과 등 의도한 기능적·약리학적 효과를 나타낼 수 있는, 본 발명의 조성물에 포함되는 유효성분의 양을 말한다. 이러한 유효량은 당업자의 통상의 능력 범위 내에서 실험적으로 결정될 수 있다. The composition for anti-obesity of the present invention may be included in any amount (effective amount) depending on the use, formulation, purpose of blending, etc., as long as the active ingredient can exhibit anti-obesity activity, and a typical effective amount is based on the total weight of the composition. when determined within the range of 0.001 wt % to 20.0 wt %. As used herein, the term "effective amount" refers to the intended functional and pharmacological effects such as anti-obesity effects when the composition of the present invention is administered to a mammal, preferably a human subject to the application, during the administration period as suggested by a medical professional. Refers to the amount of the active ingredient contained in the composition of the present invention. Such an effective amount can be determined empirically within the ordinary ability of one of ordinary skill in the art.
본 발명의 항비만 조성물은 유효성분 이외에, 항비만 효과의 상승·보강을 위하여 또는 혈압 조절 활성 등 유사활성의 부가를 통한 복용이나 섭취의 편리성을 증진시키기 위하여, 당업계에서 이미 안전성이 검증되고 해당 활성을 갖는 것으로 공지된 임의의 화합물이나 천연 추출물을 추가로 포함할 수 있다. 이러한 화합물 또는 추출물에는 각국 약전(한국에서는 "대한민국약전"), 각국 건강기능식품공전(한국에서는 식약처 고시인 "건강기능식품 기준 및 규격"임) 등의 공정서에 실려 있는 화합물 또는 추출물, 의약품의 제조·판매를 규율하는 각국의 법률(한국에서는 "약사법"임)에 따라 품목 허가를 받은 화합물 또는 추출물, 건강기능식품의 제조·판매를 규율하는 각국 법률(한국에서는 「건강기능식품에관한법률」임)에 따라 기능성이 인정된 화합물 또는 추출물이 포함된다. In addition to the active ingredient, the anti-obesity composition of the present invention has already been proven in the art for safety and to enhance the convenience of taking or ingestion through the addition of similar activities such as blood pressure control activity or increase/reinforcement of the anti-obesity effect, in addition to the active ingredient. It may further include any compound or natural extract known to have the corresponding activity. Such compounds or extracts include compounds, extracts, and pharmaceuticals listed in compendial documents such as pharmacopeias of each country (“Korea Pharmacopoeia” in Korea) and health functional food regulations of each country (“health functional food standards and specifications” announced by the Ministry of Food and Drug Safety in Korea). Each country's laws governing the manufacture and sale of compounds or extracts and health functional foods that have been approved for items in accordance with the laws of each country (the "Pharmaceuticals Act" in Korea) governing the manufacture and sale of '), and compounds or extracts whose functionality is recognized are included.
예컨대 한국 「건강기능식품에관한법률」에 따라, '체지방 감소'로 기능성이 인정된 가르시니아캄보지아 껍질 추출물, 공액 리놀렌산(유리지방산), 공액 리놀렌산(트리글리세라이드), 녹차 추출물, 키토산, 락토바실러스 가세리 BNR17(Lactobacillus gasseri BNR17), L-카르니틴타르트레이트, 그린마떼 추출물, 그린커피빈 추출물, 깻잎 추출물, 대두배아 추출물 등의 복합물, 돌외잎 주정 추출 분말, 락토페린(우유 정제 단백질), 레몬 밤 추출물 혼합 분말, 마테 열수 추출물, 미역 등 복합 추출물(잔티젠), 발효 식초 석류 복합물, 보이차 추출물, 서목태(쥐눈이콩) 펩타이드 복합물, 식물성 유지 디글리세라이드, 와일드망고 종자 추출물, 중쇄지방산(MCFA) 함유 유지, 콜레우스포스콜리 추출물, 키토올리고당, 핑거루트 추출 분말, 히비스커스 등의 복합추출물 등과, '혈압 조절'로 기능성이 인정된 L-글루타민산 유래 GABA 함유 분말, 가쯔오부시 올리고펩타이드, 나토균배양 분말, 서목태(쥐눈이콩) 펩타이드 복합물, 연어 펩타이드, 올리브 잎 추출물, 정어리 펩타이드, 카제인 가수분해물, 코엔자임 Q10, 포도씨 효소 분해 추출 분말, 해태 올리고펩티드 등과, '혈중 중성지방 개선' 기능성이 인정된 DHA 농축 유지, 글로빈 가수분해물, 난소화성 말토덱스트린, 대나무 잎 추출물, 식물성 유지 디글리세라이드, 정어리 정제 어유, 정제 오징어유 등과, '혈당 조절'로 기능성이 인정된 L-arabinose, nopal 추출물, 계피 추출 분말, 구아바 잎 추출물, 난소화성 말토덱스트린, 동결 건조 누에 분말, 마 주정 추출물, 바나바 잎 추출물, 상엽 추출물 등과, '피로 개선'으로 기능성이 인정된 발효 생성 아미노산 복합물, 헛개나무 과병 추출물, 홍경천 추출물 등과, '항스트레스'로 기능성이 인정된 L-테아닌, 아쉬아간다 추출물, 유단백가수분해물, 돌외 잎 추출물 등이 이러한 화합물 또는 추출물에 해당할 것이다.For example, garcinia cambogia bark extract, conjugated linolenic acid (free fatty acid), conjugated linolenic acid (triglyceride), green tea extract, chitosan, Lactobacillus gasseri, whose functionality has been recognized as 'body fat reduction' according to the Korean 「Health Functional Food Act」 BNR17 ( Lactobacillus gasseri BNR17), L-carnitine tartrate, green mate extract, green coffee bean extract, sesame leaf extract, soybean germ extract, etc., mixed powder of aloe vera extract powder, lactoferrin (milk refined protein), lemon balm extract , Mate hot water extract, seaweed complex extract (xantijen), fermented vinegar pomegranate complex, Puer’s tea extract, Seomoktae (snow bean) peptide complex, vegetable oil diglyceride, wild mango seed extract, medium-chain fatty acid (MCFA)-containing oil, Complex extracts such as Coleus forskohlii extract, chitooligosaccharide, finger root extract powder, hibiscus, etc., L-glutamic acid-derived GABA-containing powder, Katsuobushi oligopeptide, Nattobacterium culture powder, Seomoktae ( Peptide complex, salmon peptide, olive leaf extract, sardine peptide, casein hydrolyzate, coenzyme Q10, grape seed enzyme-decomposed extract powder, Haitai oligopeptide, etc. Decomposition product, indigestible maltodextrin, bamboo leaf extract, vegetable oil diglyceride, refined sardine refined fish oil, refined squid oil, etc., L-arabinose, nopal extract, cinnamon extract powder, guava leaf extract, whose functionality has been recognized as 'glycemic control', Indigestible maltodextrin, freeze-dried silkworm powder, hemp spirit extract, Banaba leaf extract, upper leaf extract, etc., fermented amino acid complex whose functionality has been recognized as 'relieving fatigue', safflower extract, rhododendron extract, etc., as 'anti-stress' L-theanine, ashwagandha extract, milk protein hydrolyzate, and leaf extract, etc., which have been recognized for their functionality, may correspond to these compounds or extracts.
본 발명의 조성물은 구체적인 양태에 있어서, 식품 조성물로 파악될 수 있다.In a specific embodiment, the composition of the present invention may be identified as a food composition.
본 발명의 식품 조성물은 어떠한 형태로도 제조될 수 있으며, 예컨대 차, 쥬스, 탄산음료, 이온음료 등의 음료류, 우유, 요구르트 등의 가공 유류, 껌류, 떡, 한과, 빵, 과자, 면 등의 식품류, 정제, 캡슐, 환, 과립, 액상, 분말, 편상, 페이스트상, 시럽, 겔, 젤리, 바 등의 건강기능식품 제제류 등으로 제조될 수 있다. The food composition of the present invention can be prepared in any form, for example, beverages such as tea, juice, carbonated drinks, and ion drinks, processed oils such as milk and yogurt, gums, rice cakes, Korean sweets, bread, confectionery, noodles, etc. Foods, tablets, capsules, pills, granules, liquids, powders, flakes, pastes, syrups, gels, jellies, and health functional food preparations such as bars can be manufactured.
또 본 발명의 식품 조성물은 법률상·기능상의 구분에 있어서 제조·유통 시점의 시행 법규에 부합하는 한 임의의 제품 구분을 띨 수 있다. 예컨대 한국 「건강기능식품에관한법률」에 따른 건강기능식품이거나, 한국 「식품위생법」의 식품공전(식약처 고시 「식품의 기준 및 규격」)상 각 식품유형에 따른 과자류, 두류, 다류, 음료류, 특수용도식품 등일 수 있다.In addition, the food composition of the present invention may have any product classification in terms of legal and functional classification as long as it conforms to the enforcement laws at the time of manufacture and distribution. For example, it is a health functional food according to Korea's "Health Functional Food Act", or confectionery, beans, tea, and beverages according to each food type in the Food Ordinance of Korea "Food Sanitation Act" (Ministry of Food and Drug Safety Notification "Food Standards and Specifications") , special purpose food, and the like.
본 발명의 식품 조성물에는 그 유효성분 이외에 식품첨가물이 포함될 수 있다. 식품첨가물은 일반적으로 식품을 제조, 가공 또는 보존함에 있어 식품에 첨가되어 혼합되거나 침윤되는 물질로서 이해될 수 있는데, 식품과 함께 매일 그리고 장기간 섭취되므로 그 안전성이 보장되어야 한다. 식품의 제조·유통을 규율하는 각국 법률(한국에서는 「식품위생법」임)에 따른 식품첨가물공전에는 안전성이 보장된 식품첨가물이 성분 면에서 또는 기능 면에서 한정적으로 규정되어 있다. 한국 식품첨가물공전(식약처 고시 「식품첨가물 기준 및 규격」)에서는 식품첨가물이 성분 면에서 화학적 합성품, 천연 첨가물 및 혼합 제제류로 구분되어 규정되어 있는데, 이러한 식품첨가물은 기능 면에 있어서는 감미제, 풍미제, 보존제, 유화제, 산미료, 점증제 등으로 구분된다. The food composition of the present invention may contain food additives in addition to the active ingredients thereof. Food additives can be generally understood as substances that are added and mixed or infiltrated into food in manufacturing, processing, or preserving food. Food additives with guaranteed safety are limited in terms of ingredients or functions in the Food Additives Ordinance in accordance with the laws of each country that regulates the manufacture and distribution of food (“Food Sanitation Act” in Korea). In the Korean Food Additives Code (“Food Additive Standards and Specifications” announced by the Ministry of Food and Drug Safety), food additives are classified into chemically synthetic products, natural additives, and mixed preparations in terms of ingredients. It is divided into agents, preservatives, emulsifiers, acidulants, thickeners, etc.
감미제는 식품에 적당한 단맛을 부여하기 위하여 사용되는 것으로, 천연의 것이거나 합성된 것 모두 본 발명의 식품 조성물에 사용할 수 있다. 바람직하게는 천연 감미제를 사용하는 경우인데, 천연 감미제로서는 옥수수 시럽 고형물, 꿀, 수크로오스, 프룩토오스, 락토오스, 말토오스 등의 당 감미제를 들 수 있다. The sweetener is used to impart appropriate sweetness to food, and both natural and synthetic ones may be used in the food composition of the present invention. Preferably, a natural sweetener is used. Examples of the natural sweetener include sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose, and maltose.
풍미제는 맛이나 향을 좋게 하기 위한 용도로 사용되는 것으로, 천연의 것과 합성된 것 모두 사용될 수 있다. 바람직하게는 천연의 것을 사용하는 경우이다. 천연의 것을 사용할 경우에 풍미 이외에 영양 강화의 목적도 병행할 수 있다. 천연 풍미제로서는 사과, 레몬, 감귤, 포도, 딸기, 복숭아 등에서 얻어진 것이거나 녹차잎, 둥굴레, 대잎, 계피, 국화 잎, 자스민 등에서 얻어진 것일 수 있다. 또 인삼(홍삼), 죽순, 알로에 베라, 은행 등에서 얻어진 것을 사용할 수 있다. 천연 풍미제는 액상의 농축액이나 고형상의 추출물일 수 있다. 경우에 따라서 합성 풍미제가 사용될 수 있는데, 합성 풍미제로서는 에스테르, 알콜, 알데하이드, 테르펜 등이 이용될 수 있다. Flavoring agents are used for the purpose of improving taste or aroma, and both natural and synthetic ones may be used. Preferably, it is a case where a natural thing is used. In the case of using a natural product, the purpose of nutritional enhancement in addition to flavor may be concurrently used. The natural flavoring agent may be obtained from apples, lemons, tangerines, grapes, strawberries, peaches, or the like, or obtained from green tea leaves, horseradish leaves, bamboo leaves, cinnamon, chrysanthemum leaves, jasmine, and the like. In addition, those obtained from ginseng (red ginseng), bamboo shoots, aloe vera, and ginkgo can be used. The natural flavoring agent may be a liquid concentrate or a solid extract. In some cases, a synthetic flavoring agent may be used, and the synthetic flavoring agent may include esters, alcohols, aldehydes, terpenes, and the like.
보존제로서는 소르브산칼슘, 소르브산나트륨, 소르브산칼륨, 벤조산칼슘, 벤조산나트륨, 벤조산칼륨, EDTA(에틸렌디아민테트라아세트산) 등이 사용될 수 있고, 또 유화제로서는 아카시아검, 카르복시메틸셀룰로스, 잔탄검, 펙틴 등이 사용될 수 있으며, 산미료로서는 연산, 말산, 푸마르산, 아디프산, 인산, 글루콘산, 타르타르산, 아스코르브산, 아세트산, 인산 등이 사용될 수 있다. 산미료는 맛을 증진시키는 목적 이외에 미생물의 증식을 억제할 목적으로 식품 조성물이 적정 산도로 되도록 첨가될 수 있다. 점증제로서는 현탁화 구현제, 침강제, 겔형성제, 팽화제 등이 사용될 수 있다.As a preservative, calcium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate, EDTA (ethylenediaminetetraacetic acid), etc. can be used, and as an emulsifier, acacia gum, carboxymethylcellulose, xanthan gum, and pectin can be used. Acidulants, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid and the like may be used as acidulants. The acidulant may be added so that the food composition has an appropriate acidity for the purpose of inhibiting the growth of microorganisms in addition to the purpose of enhancing the taste. As a thickening agent, a suspending agent, a settling agent, a gel-forming agent, a bulking agent, etc. can be used.
본 발명의 식품 조성물은 전술한 바의 식품첨가물 이외에, 기능성과 영양성을 보충·보강할 목적으로 당업계에 공지되고 식품첨가물로서 안정성이 보장된 생리활성 물질이나 미네랄류를 포함할 수 있다.The food composition of the present invention may contain, in addition to the food additives described above, physiologically active substances or minerals known in the art for the purpose of supplementing and reinforcing functionality and nutrition and guaranteed stability as food additives.
그러한 생리활성 물질로서는 녹차 등에 포함된 카테킨류, 비타민 B1, 비타민 C, 비타민 E, 비타민 B12 등의 비타민류, 토코페롤, 디벤조일티아민 등을 들 수 있으며, 미네랄류로서는 구연산칼슘 등의 칼슘 제제, 스테아린산마그네슘 등의 마그네슘 제제, 구연산철 등의 철 제제, 염화크롬, 요오드칼륨, 셀레늄, 게르마늄, 바나듐, 아연 등을 들 수 있다. Examples of such physiologically active substances include catechins contained in green tea, vitamins such as vitamin B1, vitamin C, vitamin E, and vitamin B12, tocopherol, dibenzoylthiamine, and the like. Minerals include calcium preparations such as calcium citrate, magnesium stearate Magnesium preparations, such as iron preparations, such as iron citrate, chromium chloride, potassium iodide, selenium, germanium, vanadium, zinc, etc. are mentioned.
본 발명의 식품 조성물에는 전술한 바의 식품첨가물이 제품 유형에 따라 그 첨가 목적을 달성할 수 있는 적량으로 포함될 수 있다.In the food composition of the present invention, the food additives as described above may be included in an appropriate amount to achieve the purpose of the addition according to the product type.
본 발명의 식품 조성물에 포함될 수 있는 기타의 식품첨가물과 관련하여서는 각국 식품공전이나 식품첨가물 공전을 참조할 수 있다.In relation to other food additives that may be included in the food composition of the present invention, reference may be made to the Food Ordinance of each country or the Food Additives Code.
본 발명의 조성물은 다른 구체적인 양태에 있어서는 약제학적 조성물로 파악될 수 있다.The composition of the present invention may be regarded as a pharmaceutical composition in another specific embodiment.
본 발명의 약제학적 조성물은 유효성분 이외에 약제학적으로 허용되는 담체를 포함하여 당업계에 공지된 통상의 방법으로 투여 경로에 따라 경구용 제형 또는 비경구용 제형으로 제조될 수 있다. 여기서 투여 경로는 국소 경로, 경구 경로, 정맥 내 경로, 근육 내 경로, 및 점막 조직을 통한 직접 흡수를 포함하는 임의의 적절한 경로일 수 있으며, 두 가지 이상의 경로를 조합하여 사용할 수도 있다. 두 가지 이상 경로의 조합의 예는 투여 경로에 따른 두 가지 이상의 제형의 약물이 조합된 경우로서 예컨대 1차로 어느 한 약물은 정맥 내 경로로 투여하고 2차로 다른 약물은 국소 경로로 투여하는 경우이다. The pharmaceutical composition of the present invention may be prepared as an oral dosage form or a parenteral dosage form according to the route of administration by a conventional method known in the art, including a pharmaceutically acceptable carrier in addition to the active ingredient. Here, the route of administration may be any suitable route including topical route, oral route, intravenous route, intramuscular route, and direct absorption through mucosal tissue, and two or more routes may be used in combination. An example of the combination of two or more routes is a case in which two or more formulations of drugs according to the route of administration are combined. For example, one drug is first administered by an intravenous route and the other drug is secondarily administered by a local route.
약학적으로 허용되는 담체는 투여 경로나 제형에 따라 당업계에 주지되어 있으며, 구체적으로는 "대한민국약전"을 포함한 각국의 약전을 참조할 수 있다. Pharmaceutically acceptable carriers are well known in the art depending on the route of administration or formulation, and specifically, reference may be made to the pharmacopoeia of each country including the "Korea Pharmacopoeia".
본 발명의 약제학적 조성물이 경구용 제형으로 제조될 경우, 적합한 담체와 함께 당업계에 공지된 방법에 따라 분말, 과립, 정제, 환제, 당의정제, 캡슐제, 액제, 겔제, 시럽제, 현탁액, 웨이퍼 등의 제형으로 제조될 수 있다. 이때 적합한 담체의 예로서는 락토스, 글루코스, 슈크로스, 덱스트로스, 솔비톨, 만니톨, 자일리톨 등의 당류, 옥수수 전분, 감자 전분, 밀 전분 등의 전분류, 셀룰로오스, 메틸셀룰로오스, 에틸셀룰로오스, 나트륨 카르복시메틸셀룰로오스, 하이드록시프로필메틸셀룰로오스 등의 셀룰로오스류, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 마그네슘 스테아레이트, 광물유, 맥아, 젤라틴, 탈크, 폴리올, 식물성유, 에탄올, 그리세롤 등을 들 수 있다. 제제화활 경우 필요에 따라적절한 결합제, 윤활제, 붕해제, 착색제, 희석제 등을 포함시킬 수 있다. 적절한 결합제로서는 전분, 마그네슘 알루미늄 실리케이트, 전분페리스트, 젤라틴, 메틸셀룰로스, 소듐 카복시메틸셀룰로스, 폴리비닐피롤리돈, 글루코스, 옥수수 감미제, 소듐 알지네이트, 폴리에틸렌 글리콜, 왁스 등을 들 수 있고, 윤활제로서는 올레산나트륨, 스테아르산나트륨, 스테아르산마그네슘, 벤조산나트륨, 초산나트륨, 염화나트륨, 실리카, 탈쿰, 스테아르산, 그것의 마그네슘염과 칼슘염, 폴리데틸렌글리콜 등을 들 수 있으며, 붕해제로서는 전분, 메틸 셀룰로스, 아가(agar), 벤토나이트, 잔탄 검, 전분, 알긴산 또는 그것의 소듐 염 등을 들 수 있다. 또 희석제로서는 락토즈, 덱스트로즈, 수크로즈, 만니톨, 소비톨, 셀룰로스, 글라이신 등을 들 수 있다. When the pharmaceutical composition of the present invention is prepared as an oral dosage form, powder, granules, tablets, pills, dragees, capsules, liquids, gels, syrups, suspensions, wafers according to methods known in the art together with a suitable carrier It can be prepared in a formulation such as Examples of suitable carriers include sugars such as lactose, glucose, sucrose, dextrose, sorbitol, mannitol, and xylitol, starches such as corn starch, potato starch, wheat starch, cellulose, methylcellulose, ethylcellulose, sodium carboxymethylcellulose, Cellulose such as hydroxypropylmethylcellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, magnesium stearate, mineral oil, malt, gelatin, talc, polyol, vegetable oil, ethanol, grease Serol etc. are mentioned. In the case of formulation activity, an appropriate binder, lubricant, disintegrant, colorant, diluent, etc. may be included as needed. Suitable binders include starch, magnesium aluminum silicate, starch ferrist, gelatin, methylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone, glucose, corn sweetener, sodium alginate, polyethylene glycol, wax, and the like, and oleic acid as lubricant. sodium, sodium stearate, magnesium stearate, sodium benzoate, sodium acetate, sodium chloride, silica, talcum, stearic acid, magnesium salts and calcium salts thereof, polyethylene glycol, etc., and the disintegrating agent is starch, methyl cellulose , agar, bentonite, xanthan gum, starch, alginic acid or its sodium salt. Examples of the diluent include lactose, dextrose, sucrose, mannitol, sorbitol, cellulose, and glycine.
본 발명의 약제학적 조성물이 비경구용 제형으로 제조될 경우, 적합한 담체와 함께 당업계에 공지된 방법에 따라 주사제, 경피 투여제, 비강 흡입제 및 좌제의 형태로 제제화될 수 있다. 주사제로 제제화할 경우 적합한 담체로서는 수성 등장 용액 또는 현탁액을 사용할 수 있으며, 구체적으로는 트리에탄올 아민이 함유된 PBS(phosphate buffered saline)나 주사용 멸균수, 5% 덱스트로스 같은 등장 용액 등을 사용할 수 있다. 경피 투여제로 제제화할 경우 연고제, 크림제, 로션제, 겔제, 외용액제, 파스타제, 리니멘트제, 에어롤제 등의 형태로 제제화할 수 있다. 비강 흡입제의 경우 디클로로플루오로메탄, 트리클로로플루오로메탄, 디클로로테트라플루오로에탄, 이산화탄소 등의 적합한 추진제를 사용하여 에어로졸 스프레이 형태로 제제화할 수 있으며, 좌제로 제제화할 경우 그 담체로는 위텝솔(witepsol), 트윈(tween) 61, 폴리에틸렌글리콜류, 카카오지, 라우린지, 폴리옥시에틸렌 소르비탄 지방산 에스테르류, 폴리옥시에틸렌 스테아레이트류, 소르비탄 지방산 에스테르류 등을 사용할 수 있다.When the pharmaceutical composition of the present invention is prepared for parenteral use, it may be formulated in the form of injections, transdermal administrations, nasal inhalants and suppositories together with suitable carriers according to methods known in the art. When formulated as an injection, an aqueous isotonic solution or suspension may be used as a suitable carrier, and specifically, PBS (phosphate buffered saline) containing triethanolamine, sterile water for injection, or isotonic solution such as 5% dextrose may be used. . When formulated for transdermal administration, it can be formulated in the form of an ointment, a cream, a lotion, a gel, an external solution, a pasta agent, a liniment agent, an air roll, and the like. In the case of nasal inhalants, it can be formulated in the form of an aerosol spray using a suitable propellant such as dichlorofluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide, and the like. witepsol), tween 61, polyethylene glycols, cacao fat, laurin fat, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene stearate, sorbitan fatty acid esters, and the like can be used.
약제학적 조성물의 구체적인 제제화와 관련하여서는 당업계에 공지되어 있으며, 예컨대 문헌[Remington's Pharmaceutical Sciences(19th ed., 1995)] 등을 참조할 수 있다. 상기 문헌은 본 명세서의 일부로서 간주 된다.Specific formulations of pharmaceutical compositions are known in the art, and reference may be made to, for example, Remington's Pharmaceutical Sciences (19th ed., 1995). This document is considered a part of this specification.
본 발명의 약제학적 조성물의 바람직한 투여량은 환자의 상태, 체중, 성별, 연령, 환자의 중증도, 투여 경로에 따라 1일 0.001mg/kg ~ 10g/kg 범위, 바람직하게는 0.001mg/kg ~ 1g/kg 범위일 수 있다. 투여는 1일 1회 또는 수회로 나누어 이루어질 수 있다. 이러한 투여량은 어떠한 측면으로든 본 발명의 범위를 제한하는 것으로 해석되어서는 아니 된다. A preferred dosage of the pharmaceutical composition of the present invention is in the range of 0.001 mg/kg to 10 g/kg per day, preferably 0.001 mg/kg to 1 g, depending on the patient's condition, weight, sex, age, severity of the patient, and the route of administration. It can be in the range /kg. Administration may be performed once or divided into several times a day. These dosages should not be construed as limiting the scope of the invention in any respect.
전술한 바와 같이, 본 발명에 따르면 흰여뀌 추출물을 이용한 항비만용 조성물을 제공할 수 있다. 본 발명의 항비만용 조성물 등은 기능성 식품, 약품 등으로 제품화될 수 있다.As described above, according to the present invention, it is possible to provide a composition for anti-obesity using the extract The composition for anti-obesity of the present invention may be commercialized as a functional food, drug, or the like.
도 1는 마우스 지방전구세포인 3T3-L1에 흰여뀌 추출물을 농도별로 처리한 후 Oil Red O 시약으로 염색한 현미경 사진과 세포의 지방량을 정량한 결과이다. 1 is a photomicrograph of mouse preadipocytes, 3T3-L1, treated with extract by concentration, and then stained with Oil Red O reagent and quantification of the amount of fat in the cells.
이하 본 발명을 실시예 및 실험예를 참조하여 설명한다. 그러나 본 발명의 범위가 이러한 실시예 및 실험예에 한정되는 것은 아니다.Hereinafter, the present invention will be described with reference to Examples and Experimental Examples. However, the scope of the present invention is not limited to these Examples and Experimental Examples.
<< 실시예Example > 흰여뀌 추출물의 제조> Manufacture of white fern extract
흰여뀌(추출부위, 지상부) 건조 분말에 10배 중량의 70% 에탄올을 첨가하여 실온에서 24시간 침출한 뒤 와트만(whatman paper) 여과지 No.2로 여과한 후, 상기 여과액을 감압농축하고 동결 건조하여 고형상의 흰여뀌 추출물을 제조하였다. After leaching for 24 hours at room temperature by adding 70% ethanol by 10 times weight to the dry powder of white sagebrush (extraction part, above-ground part) dry powder, filtered with Whatman paper filter paper No. 2, the filtrate was concentrated under reduced pressure and frozen It was dried to prepare a solid extract of white fenugreek.
<< 실험예Experimental example > 비만 개선 활성 실험> Obesity improvement activity test
마우스 전구지방세포인 3T3-L1(ATCC CL-173)은 10 % BCS DMEM 배지를 넣고 37℃, 5% CO2 의 조건에서 배양하였다. 3T3-L1 전구지방세포를 24 well plate에 5×104/well의 세포수로 분주한 후 100% confluency 시점이 되면 2일 동안 더 유지시켰다. 전구지방세포는 MDI(0.5 mM 3-isobutyl-1-methylxanthine (Calbiochem 410957), 1 uM dexamethasone (Calbiochem 265005), 1 ug/ml insulin(Sigma I9278))를 포함하는 10% FBS DMEM 배지로 지방세포 분화를 2일 동안 유도하였고, 배양 48 시간 후, 1 ug/ml insulin이 함유된 10% FBS DMEM으로 이틀 동안 배양하였다. 그 후 2일 마다 4일 동안 10% FBS DMEM 배양액으로 교체하였다. 지방세포 분화 유도 동안 실시예의 추출물을 50, 100 ㎍/ml의 농도로 각 배양액에 처리하였고, 분화가 완성되는 시점인 8일째에 지방세포 분화 정도를 관찰하였다. 지방세포 분화 정도는 Oil Red O 염색을 통해 1차적으로 현미경을 통해 확인하였고, 지방세포 염색 정도는 510 nm 흡광도에서 ELISA Reader (SPECTRAmax 340PC, Molecular Devices, USA)를 이용하여 세포의 분화된 지방량을 측정하였다. 결과는 농도별 3번 반복실험을 통하여 산출하였다. Mouse progenitor adipocytes, 3T3-L1 (ATCC CL-173), were cultured at 37° C. and 5% CO 2 in 10% BCS DMEM medium. 3T3-L1 precursor adipocytes were seeded in a 24-well plate with a cell number of 5×10 4 /well, and then maintained for 2 more days when 100% confluency reached. Preadipocytes were differentiated into adipocytes with 10% FBS DMEM medium containing MDI (0.5 mM 3-isobutyl-1-methylxanthine (Calbiochem 410957), 1 uM dexamethasone (Calbiochem 265005), 1 ug/ml insulin (Sigma I9278)). was induced for 2 days, and after 48 hours of incubation, it was cultured for 2 days with 10% FBS DMEM containing 1 ug/ml insulin. After that, every 2 days, the culture medium was replaced with 10% FBS DMEM for 4 days. During the induction of adipocyte differentiation, the extracts of Examples were treated in each culture medium at a concentration of 50 and 100 μg/ml, and the degree of adipocyte differentiation was observed on the 8th day, when differentiation was completed. The degree of adipocyte differentiation was primarily confirmed through a microscope through Oil Red O staining, and the degree of adipocyte staining was measured by measuring the amount of differentiated fat in the cells using an ELISA Reader (SPECTRAmax 340PC, Molecular Devices, USA) at 510 nm absorbance. did The results were calculated through three repeated experiments for each concentration.
결과를 도 1에 나타내었는데, 도 1을 참조하여 보면, 흰여뀌 추출물이 뚜렷하게 지방전구세포의 지방세포로의 분화 억제 활성과 지방 축적 억제 활성(IC50=49.04㎍/mL)을 가짐을 알 수 있다. The results are shown in FIG. 1 , and referring to FIG. 1 , it can be seen that the extract of hyacinth has a distinct inhibitory activity of preadipocyte differentiation into adipocytes and an activity of inhibiting fat accumulation (IC 50 =49.04 μg/mL).
Claims (4)
A food composition for anti-obesity comprising a mixed solvent extract of water and ethanol from above ( Persicaria lapathifolia ) having a fat accumulation inhibitory activity.
상기 추출물은 70% 에탄올 추출물인 것을 특징으로 하는 항비만용 식품 조성물.
According to claim 1,
The extract is a food composition for anti-obesity, characterized in that it is a 70% ethanol extract.
A pharmaceutical composition for anti-obesity comprising, as an active ingredient, a mixed solvent extract of water and ethanol from an above-ground part of the white sagebrush ( Persicaria lapathifolia ) having fat accumulation inhibitory activity.
상기 추출물은 70% 에탄올 추출물인 것을 특징으로 하는 항비만용 약제학적 조성물.
4. The method of claim 3,
The extract is an anti-obesity pharmaceutical composition, characterized in that 70% ethanol extract.
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