KR102372554B1 - Cosmetic composition containing the extract of Cleome spinoza - Google Patents

Cosmetic composition containing the extract of Cleome spinoza Download PDF

Info

Publication number
KR102372554B1
KR102372554B1 KR1020150087404A KR20150087404A KR102372554B1 KR 102372554 B1 KR102372554 B1 KR 102372554B1 KR 1020150087404 A KR1020150087404 A KR 1020150087404A KR 20150087404 A KR20150087404 A KR 20150087404A KR 102372554 B1 KR102372554 B1 KR 102372554B1
Authority
KR
South Korea
Prior art keywords
extract
cosmetic composition
cleome
composition containing
spinoza
Prior art date
Application number
KR1020150087404A
Other languages
Korean (ko)
Other versions
KR20160150217A (en
Inventor
박상재
김경희
Original Assignee
(주)메디언스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주)메디언스 filed Critical (주)메디언스
Priority to KR1020150087404A priority Critical patent/KR102372554B1/en
Publication of KR20160150217A publication Critical patent/KR20160150217A/en
Application granted granted Critical
Publication of KR102372554B1 publication Critical patent/KR102372554B1/en

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

본 발명은 풍접초 추출물을 유효성분으로 함유하는 화장료 조성물에 관한것으로 풍접초의 지상부위를 용매로 추출하여 얻어진 추출물을 이용한 화장료 조성물을 제조하여 피부미백, 항산화, 피부보호 효과를 가지는 화장료 조성물의 제공에 관한 것이다. The present invention relates to a cosmetic composition containing an extract of chrysanthemum as an active ingredient, and relates to the provision of a cosmetic composition having skin whitening, antioxidant, and skin protection effects by preparing a cosmetic composition using the extract obtained by extracting the above-ground part of fenugreek seeds as an active ingredient will be.

Figure 112015059531104-pat00001
Figure 112015059531104-pat00001

Description

풍접초 추출물을 함유하는 화장료 조성물{Cosmetic composition containing the extract of Cleome spinoza}Cosmetic composition containing the extract of Cleome spinoza

본 발명은 풍접초의 지상부를 원료로 하여 얻어지는 추출물을 이용한 화장료 조성물에 관한 것으로 항산화 효과를 가지며, 피부보호효과를 가지는 것을 특징으로 하는 화장료 조성물을 제공하고 있다.The present invention relates to a cosmetic composition using an extract obtained by using the above-ground part of the genus chrysanthemum as a raw material, and provides a cosmetic composition characterized in that it has an antioxidant effect and a skin protection effect.

풍접초는 1년생 식물로서 학명은 Cleome spinosa Linne이며, 원산지는 아메리카로 알려져 있으나, 중국에서는 아주 오래 전부터 재배한 것으로 알려져 있는 족두리 모양의 꽃을 피우는 식물로, 한국에서는 일명 족두리꽃이라고도 불리고 있다. 이 식물은 6월에서 10월까지 장기간 지속적으로 개화를 하며, 좁쌀크기의 씨를 다수 맺는다. 그러나, 일반적인 1년생 식물들과 달리 진딧물의 발생이 나타나지 않는 점, 특유의 향이 있어 해충들의 접근이 적은 점 등이 재배 과정에서 알게된 특징이다. 따라서 본 발명자는 이를 근거로 풍접초의 지상부위를 원료로 하여 추출물을 제조하고, 그 주요성분을 동정하고 그 생리활성을 조사하여 이를 화장료 조성물에 적용하는 것에 의하여 본 발명을 완성하게 되었다. As an annual plant, the scientific name is Cleome spinosa Linne, and the place of origin is known to America, but it is a plant that blooms a foot-shaped flower known to have been cultivated for a very long time in China. This plant blooms continuously for a long period of time from June to October and produces many seeds the size of millet. However, unlike general annual plants, the occurrence of aphids does not appear, and the fact that pests have little access due to its unique scent are the characteristics learned during the cultivation process. Therefore, the present inventors have completed the present invention by preparing an extract using the above-ground part of Prunus chrysanthemum as a raw material based on this, identifying its main components, examining its physiological activity, and applying it to a cosmetic composition.

지금까지 알려진 클레오메 기난드라(Cleome gynandra)는 한국명으로 백화채라고 하는 것으로 살충, 구충, 화장료 조성물 등으로 사용되어왔으며 일부에서 클레오메 기난드라를 풍접초로 잘못알고 있는 경우도 있어 왔다. 풍접초는 직접 클레오메 기난드라와는 속명은 같으나 종명이 다른 다른종이며, 현재 풍접초를 이용한 화장료 조성물과 관련된 내용이 없는 바, 본 발명자는 다년간 풍접초를 재배하면서 풍접초의 재배 과정에서 얻어진 특성을 바탕으로 연구개발하여 본 발명을 완성하게 되었다. Cleome gynandra, known so far, is called baekhwachae in Korean and has been used as an insecticide, insect repellent, and cosmetic composition. The ginseng plant has the same genus name as Cleome Ginandra, but is a different species, and there is currently no content related to the cosmetic composition using the ginseng plant. The present invention was completed through research and development.

대한민국 특허 출원 10-2013-7018864Korean Patent Application 10-2013-7018864 대한민국 특허 출원 10-2013-7007906Korean Patent Application 10-2013-7007906 대한민국 특허 출원 10-2006-7017372Korean Patent Application 10-2006-7017372

Natural product communications, 5(8), 2010, 1301-1306Natural product communications, 5(8), 2010, 1301-1306

풍접초의 지상부위의 추출물을 이용하여 항산화활성을 확인하고, 주요성분을 동정하여, 이를 근거로 피부보호 및 항산화 효과를 가지는 풍접초추출물을 함유하는 화장료 조성물을 제시하고자 한다. The purpose of this study is to present a cosmetic composition containing the extract of the ginseng plant having anti-oxidation and skin protection effects by confirming the antioxidant activity by using the extract of the above-ground part of the chrysanthemum, and identifying the main components.

본 발명은 풍접초의 지상부위를 용매를 이용하여 추출하고 주요성분의 화학적인 구조를 밝히며, 생리활성을 규명하는 방법에 의하여 풍접초추출물을 함유하는 화장료 조성물을 제공하고자 한다. An object of the present invention is to provide a cosmetic composition containing the extract of the genus oleifera by a method of extracting the above-ground part of the champignon extract using a solvent, revealing the chemical structure of the main component, and elucidating the physiological activity.

본 발명의 풍접초 추출물을 함유하는 화장료 조성물은 천연추출물을 함유함으로써 보다 안전성이 강화되며, 부작용이 없고, 항산화 활성에 기반한 피부보호효과를 가지는 화장료 조성물을 제공할 수 있다. 또한 천연추출물로서 기존의 화장료의 제조과정에서 에멀젼 등의 형태로 가공되어 첨가될 경우 피부보호, 항산화 효과를 얻을 수 있어 현저하게 개선된 화장료 조성물을 제공할 수 있다. The cosmetic composition containing the extract of the present invention can provide a cosmetic composition with enhanced safety, no side effects, and a skin protection effect based on antioxidant activity by containing a natural extract. In addition, as a natural extract, when it is processed and added in the form of an emulsion in the manufacturing process of conventional cosmetics, skin protection and antioxidant effects can be obtained, thereby providing a remarkably improved cosmetic composition.

도1 : 성분 1의 질량분석 크로마토그램.
도2 : 성분 2의 질량분석 크로마토그램.
도3 : 성분 3의 질량분석 크로마토그램.
도4 : 성분 4의 질량분석 크로마토그램.
도5 : 성분 5의 질량분석 크로마토그램.
도6 : 성분 6의 질량분석 크로마토그램.
도7 : 성분 7의 질량분석 크로마토그램.Figure 1: Mass spectrometry chromatogram of component 1.
Figure 2: Mass spectrometry chromatogram of component 2.
Figure 3: Mass spectrometry chromatogram of component 3.
Figure 4: Mass spectrometry chromatogram of component 4.
Figure 5: Mass spectrometry chromatogram of component 5.
Figure 6: Mass spectrometry chromatogram of component 6.
Figure 7: Mass spectrometry chromatogram of component 7.

풍접초는 현화식물문(Magnoliophyta), 목련강(Magnoliopsida), 풍접초목(Capparales), 풍접초과(Capparaceae), 풍접초속(Cleome)에 속하며 종명은 spinosa 이다. 학명은 Cleome spinoza이며, 아메리카가 원산지이나 한국에 들여온 기록은 찾을 수 없다. It belongs to Magnoliophyta, Magnoliopsida, Capparales, Capparaceae, and Cleome, and the species name is spinosa. The scientific name is Cleome spinoza, and although it is native to America, there is no record of its introduction to Korea.

풍접초는 다 자랄 경우 높이 1m 정도이고, 줄기의 전체에 선모와 잔가시가 있으며 곧게 자란다. 잎은 어긋나며 장상복엽이고, 긴 타원형 바소꼴모양의 소엽은 5~7개이며 끝이 뾰족하고 가장자리가 밋밋하다. 꽃은 8~9월에 붉은 빛을 띠는 자주색 또는 흰색이며 총상화서로 피고 원줄기 끝에 달린다. 포는 좁은 달걀모양이며 꽃받침잎은 길이 6mm 정도의 선형 바소꼴모양으로 4개이고 뒤로 젖혀지며 꽃잎은 거꾸로 된 달걀모양이고 주황색을 띠는 수술은 4개이고 암술은 1개이다. 열매는 삭과로 길이 5~11cm 정도고 선모양이고 아랫부분이 가늘어져 대와 같이 되며 종자는 좁쌀 크기로 회색에서 갈색이다. When fully grown, the chrysanthemum plant is about 1 m high, and has glandular hairs and thorns all over the stem, and grows straight. The leaves are alternate phyllotaxis and are oblong, and there are 5-7 long, oval, lanceolate-shaped leaflets with sharp ends and flat edges. Flowers are reddish purple or white in August-September, bloom in raceme and hang at the end of the main stem. The bract is narrow egg-shaped, and the sepals are 4 in a linear lanceolate shape with a length of about 6mm, and the petals are inverted egg-shaped, with 4 orange stamens and 1 pistil. The fruits are capsules, about 5~11cm long, linear, and the lower part is thinned to look like a stalk. The seeds are the size of millet and are gray to brown.

풍접초는 2~3월에 싹을 틔우면 6월경에 꽃을 볼 수 있으며, 잎에는 특유의 향이 있고 가시가 있으며, 일반적으로 10월까지 계속하여 대가 성장하면서 꽃이 핀다. If buds sprout from February to March, flowers can be seen around June. The leaves have a characteristic scent and thorns, and generally continue to bloom until October as the stem grows.

사용하는 부위는 지상부로 줄기, 잎, 꽃을 포함한다. 먼저 이들 부위를 용매를 이용하여 추출하게 되는데 사용하는 용매로는 물, 에탄올, 메탄올, 글리세린, 부탄올, 아세톤, 에테르, 헥산, 클로로포름, 에틸아세테이트 로 구성되는 군 중에서 단독, 혼합 또는 물과의 희석한 것을 사용가능하다. 추출된 성분은 여과하여 불용성 물질을 제거하고 투명한 맑은 여액을 얻고, 이를 적절한 농도f로 희석하거나, 농축하여 용매를 제거하고 화장료 조성물과 혼합하여 제형화가 가능하다. 보다 좋게는 물, 에탄올을 주로 사용할 수 있으며, 가장 좋게는 70%(v/v)의 주정을 사용하는 것이 좋다. The part used is the above-ground part and includes stems, leaves, and flowers. First, these sites are extracted using a solvent. The solvent used is water, ethanol, methanol, glycerin, butanol, acetone, ether, hexane, chloroform, and ethyl acetate alone, mixed or diluted with water. that is available The extracted components are filtered to remove insoluble substances to obtain a clear clear filtrate, which can be diluted to an appropriate concentration f, or concentrated to remove the solvent and mixed with a cosmetic composition for formulation. Better still, water and ethanol can be mainly used, and it is best to use 70% (v/v) alcohol.

이하, 본 발명을 하기의 실시예로 보다 자세하게 설명하고자 한다. 다만 본 발명의 범위가 하기의 실험예 및 실시예에 의하여 한정되지는 않는다.Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the scope of the present invention is not limited by the following experimental examples and examples.

실험예 1 : 풍접초 주정 추출물의 제조Experimental Example 1: Preparation of alcohol extract of Pungjae chrysanthemum

풍접초 줄기 및 잎을 말린 것으로 하여 100g을 준비하고, 여기에 물로 희석한 70%(v/v)의 주정을 10배수 가하고, 3시간 동안 추출한 다음 여과하여 불용성 물질을 제거하고 830ml을 얻었다. 이 중 일부의 시료를 취하여 함유된 성분의 동정을 위한 시료로 사용하였다. 100 g of dried chrysanthemum stems and leaves were prepared, 10 times 70% (v/v) alcohol diluted with water was added thereto, extracted for 3 hours, filtered to remove insoluble substances, and 830 ml was obtained. Some of these samples were taken and used as samples for identification of the contained components.

주요성분의 동정은 1차적으로 GCMS를 이용하여 수행하고 Database를 이용하여 주요성분의 화학구조를 동정하였다. 그 결과 다음의 표1에 나타낸 것과 같이 주요성분으로 7종을 확인 하였다.Identification of major components was primarily performed using GCMS, and the chemical structure of major components was identified using a database. As a result, as shown in Table 1 below, 7 types were identified as main components.

구 분division 성분명Ingredient name 화학식chemical formula 성분1ingredient 1 1-methoxy-2-propyl acetate1-methoxy-2-propyl acetate C6H12O3 C 6 H 12 O 3 성분2ingredient 2 2-butoxy ethanol2-butoxy ethanol C6H14O2 C 6 H 14 O 2 성분3ingredient 3 1-ethyl-4-methyl benzene1-ethyl-4-methyl benzene C9H12 C 9 H 12 성분4ingredient 4 3-ethoxy ethyl propanoate3-ethoxy ethyl propanoate C7H14O3 C 7 H 14 O 3 성분5ingredient 5 1,3,5-trimethyl benzene1,3,5-trimethyl benzene C9H12 C 9 H 12 성분6ingredient 6 2-ethyl hexanol2-ethyl hexanol C8H18OC 8 H 18 O 성분7Ingredient 7 1,2,3,5-tetramethyl benzene1,2,3,5-tetramethyl benzene C10H14 C 10 H 14

또한 도1~7에 이들 성분의 질량분석크로마토그램을 보였다. In addition, mass spectrometry chromatograms of these components are shown in FIGS. 1 to 7 .

실험예 2 : 항산화 효과의 검증Experimental Example 2: Verification of antioxidant effect

상기의 추출물을 이용하여 다음과 같이 항산화효과를 검증하였다.The antioxidant effect was verified using the extract as follows.

1.1-diphenyl-2-picrylhydrazyl(DPPH)용액을 80 ㎍/㎖ in EtOH 로 조제하고, 이 용액 1㎖에 각 분획을 2㎎/㎖의 농도가 되도록 에탄올에 용해 시킨 후 517nm에서 흡광도를 측정하는 방법에 의하여 항산화효과를 비교하였다. 항산화 교과가 높을 수록 발색을 억제하는 효과가 있어 색이 연하게 나타나게 된다. 1.1-diphenyl-2-picrylhydrazyl (DPPH) solution was prepared with 80 μg/ml in EtOH, and each fraction was dissolved in ethanol to a concentration of 2 mg/ml in 1 ml of this solution, and absorbance was measured at 517 nm. The antioxidant effect was compared by The higher the antioxidant content, the lighter the color appears.

전자공여능 또는 항산화력으로 표시는,Indicated by electron donating ability or antioxidant power,

100-{100*(샘플의 흡광도 - 블랭크의 흡광도)/(기준물질 흡광도-블랭크의 흡광도)}에 의하여 산출하였다. 100-{100*(absorbance of sample - absorbance of blank)/(absorbance of reference material - absorbance of blank)}.

그 결과 본 발명의 상기 실시예 1에서 제조한 풍접초 추출물은 DPPH 라디칼의 50%를 제거하는 효과를 가지는 농도를 의미하는 IC50 값이 11ug/ml로 나타나 일반적인 식물의 추출물과 비교할 때 10배 이상의 높은 항산화력을 보였다.As a result, the extract prepared in Example 1 of the present invention showed an IC 50 value of 11 ug/ml, which means a concentration having an effect of removing 50% of DPPH radicals, which is more than 10 times higher than that of a typical plant extract. showed antioxidant activity.

실험예 3 : 미백효과 실험Experimental Example 3: Whitening effect experiment

실험예 1의 추출물을 최종농도가 0.3%(w/v)가 되도록 하여, 알부틴 수용액과 함께 각각 B16F10 멜라노마 세포의 배양액에 첨가하여 2일간 배양한 후 세포를 회수하고, 이를 1N NaOH(10%DMSO포함)를 가하여 섭씨 90도에서 한시간 동안 반응시켜 멜라닌이 충분히 녹아 나오도록 한 후, ELISA를 이용하여 흡광도를 측정하여 미처리구를 기준으로 멜라닌의 양을 비교하는 방법으로 멜라닌 생성저해율을 계산하였다. 그 결과 본 발명의 추출물은 멜라닌 생성비율을 17.9%로 억제하여 억제효과가 82.1%에 달하는 뛰어난 멜라닌 생성억제 효과를 보였다.The extract of Experimental Example 1 was made to have a final concentration of 0.3% (w/v), and it was added to the culture solution of each B16F10 melanoma cell together with an aqueous arbutin solution, and the cells were recovered after culturing for 2 days, and this was 1N NaOH (10% DMSO (including DMSO) was added and reacted at 90 degrees Celsius for one hour so that melanin was sufficiently dissolved, and then the melanin production inhibition rate was calculated by measuring the absorbance using ELISA and comparing the amount of melanin to the untreated group. As a result, the extract of the present invention suppressed the melanin production rate to 17.9% and showed an excellent melanin production inhibitory effect reaching 82.1% of the inhibitory effect.

실험예 4 : 세포독성시험Experimental Example 4: Cytotoxicity test

상기의 실험예 1의 추출물을 이용하여 세포 독성 여부를 확인하기 위하여 추출물을 처리하고, 배양한 후 살아있는 세포의 수를 측정하였다. 그 결과 본 발명의 추출물은 0.2g/ml의 매우 높은 농도로 처리하여도 세포의 사멸을 초래하지 않아 세포에 대한 독성이 거의 없으며, 매우 안전한, 부작용이 없는 화장료 조성물로 사용가능함을 알 수 있었다.Using the extract of Experimental Example 1, the extract was treated and cultured to determine whether cytotoxicity was present, and then the number of living cells was measured. As a result, it was found that the extract of the present invention did not cause apoptosis even when treated at a very high concentration of 0.2 g/ml, and thus had little toxicity to cells, and could be used as a very safe cosmetic composition without side effects.

상기 실험예 1의 추출물을 함유하는 피부외용연고 처방(제조예 1), 및 에센스(제조예2) 처방으로 다음의 표 2와 같이 제조하였다. 각 함량은 무게비를 의미함.The formulation for external skin ointment containing the extract of Experimental Example 1 (Preparation Example 1), and the essence (Preparation Example 2) were prepared as shown in Table 2 below. Each content means a weight ratio.

구성성분Ingredients 제조예 1Preparation Example 1 제조예 2Preparation 2 풍접초추출물wind chimney extract 8.58.5 0.80.8 경납brazing 44 00 벤조산나트륨sodium benzoate 미량a very small amount 0.010.01 글리세린glycerin 77 1313 부칠렌글리콜butylene glycol 0.10.1 44 솔비탄스테아레이트Sorbitan Stearate 0.80.8 1One 에탄올ethanol 0.10.1 77 폴리 솔베이트polysorbate 0.10.1 0.20.2 파라옥시 안식향산메틸methyl paraoxybenzoate 00 0.10.1 정제수Purified water 00 to 100to 100 바셀린vaseline to 100to 100 00

실험예 5 : 피부보호효과의 확인Experimental Example 5: Confirmation of skin protection effect

건강한 남녀 각 10명을 선정하고 2개의 그룹으로 나누어 양팔의 하박부에 직경 15mm의 구멍이 난 알미늄을 붙이고, Solar stimulatio를 이용하여 60mJ/cm2의 광량을 조사하였다. 조사하기 2일 전 부터 조사 후 3일째까지 1일 2회씩 실시예 1의 제조예1에 기재된 크림을 도포한 그룹과 그렇지 않고 무처치한 그룹간의 피부상태를 비교하였다. 그 결과 피부에 나타난 홍반의 수에 있어 본 발명의 크림을 도포한 경우 홍반이 나타난 경우가 0으로 음성대조군이 3.5에 비하여 현저하게 뛰어난 피부 보호 효과가 있음을 알 수 있었다. 10 healthy males and females were selected each, divided into two groups, and aluminum with a diameter of 15 mm was attached to the lower arm of both arms, and the amount of light of 60 mJ/cm2 was irradiated using solar stimulation. The skin condition was compared between the group to which the cream described in Preparation Example 1 of Example 1 was applied twice a day from 2 days before the irradiation to the 3rd day after the irradiation and the group to which it was not treated. As a result, in the number of erythema appeared on the skin, when the cream of the present invention was applied, the case of erythema was 0, and it was found that the negative control group had a remarkably excellent skin protection effect compared to 3.5.

본 발명은 풍접초추출물을 함유하는 화장료 조성물에 관한 것으로 로션, 크림, 스킨, 에센스 등의 화장품을 제조하는데 첨가하여 피부보호, 미백, 항산화 등의 효과를 제공할 수 있으며 동시에 천연물로서 독성이 없는 안전한 화장품의 제조에 이용될 수 있다. The present invention relates to a cosmetic composition containing an extract of Pungsinosaurus extract, which can be added to manufacture cosmetics such as lotions, creams, skins, essences, etc. to provide skin protection, whitening, antioxidant effects, etc. can be used in the manufacture of

GCMS : gas chromatography-mass spectrophotometer
ELISA: Enzyme-linked immunosorbent assayGCMS: gas chromatography-mass spectrophotometer
ELISA: Enzyme-linked immunosorbent assay

Claims (3)

풍접초 추출물이 1-methoxy-2-propyl acetate, 2-butoxy ethanol, 1-ethyl-4-methyl benzene, 3-ethoxy ethyl propanoate, 1,3,5-trimethyl benzene, 2-ethyl hexanol, 1,2,3,5-tetramethyl benzene 으로 구성된 군 중에서 한가지 이상을 함유하는 것을 특징으로 하는 화장료 조성물


The extracts of Pungsemyeonsopsis 1-methoxy-2-propyl acetate, 2-butoxy ethanol, 1-ethyl-4-methyl benzene, 3-ethoxy ethyl propanoate, 1,3,5-trimethyl benzene, 2-ethyl hexanol, 1,2, A cosmetic composition comprising at least one from the group consisting of 3,5-tetramethyl benzene


 삭제delete 삭제delete
KR1020150087404A 2015-06-19 2015-06-19 Cosmetic composition containing the extract of Cleome spinoza KR102372554B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020150087404A KR102372554B1 (en) 2015-06-19 2015-06-19 Cosmetic composition containing the extract of Cleome spinoza

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020150087404A KR102372554B1 (en) 2015-06-19 2015-06-19 Cosmetic composition containing the extract of Cleome spinoza

Publications (2)

Publication Number Publication Date
KR20160150217A KR20160150217A (en) 2016-12-29
KR102372554B1 true KR102372554B1 (en) 2022-03-11

Family

ID=57736599

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020150087404A KR102372554B1 (en) 2015-06-19 2015-06-19 Cosmetic composition containing the extract of Cleome spinoza

Country Status (1)

Country Link
KR (1) KR102372554B1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010523527A (en) * 2007-04-05 2010-07-15 ピエール、ファブレ、デルモ‐コスメティーク Pleurotus extract used in pharmaceutical and cosmetic compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010523527A (en) * 2007-04-05 2010-07-15 ピエール、ファブレ、デルモ‐コスメティーク Pleurotus extract used in pharmaceutical and cosmetic compositions

Also Published As

Publication number Publication date
KR20160150217A (en) 2016-12-29

Similar Documents

Publication Publication Date Title
Gull et al. Capparis species: A potential source of bioactives and high-value components: A review
KR102032873B1 (en) Antioxidant and moisturizing cosmetic composition
Sharma et al. Ethnomedicinal and pharmacological uses of Curcuma caesia
KR101664025B1 (en) Cosmetic composition containing natural herb extracts
KR20180137952A (en) Mask pack
Alitonou et al. Chemical and biological investigation on volatile constituents of pentadesma butyracea sabine (clusiaceae) from Benin
KR20150092606A (en) Cosmetic composition comprising the extract of plant
KR102372554B1 (en) Cosmetic composition containing the extract of Cleome spinoza
KR101146262B1 (en) Composition for Skin External Application Comprising Extract of Pharbitis nil Callus
KR20190079338A (en) A cosmetic composition comprising fractions of extracts of flower of Forsythia koreana as an active ingredient
Hewageegana et al. A comparison of the physico-chemical and phytochemical parameters of glands/hairs of fruits and leaves of Mallotus philippensis (Lam.) Muell. Arg. grown in Sri Lanka
KR101592084B1 (en) Cosmetic composition comprising the extract of plant
KR20070000597A (en) Cosmetic composition for preventing skin aging
KR20140103633A (en) Cosmetic composition containing extract of Bambusoideae and Reynoutria japonica for anti-wrinkle or anti-aging
Garg et al. Exploring the potential of Moringa oleifera Lam in skin disorders and cosmetics: nutritional analysis, phytochemistry, geographical distribution, ethnomedicinal uses, dermatological studies and cosmetic formulations
KR101981678B1 (en) Complex antioxidant extract and cosmetic composition for promoting hair growth and improving scalp and hair
Bhopi et al. A Review on Zizyphus jujuba: A Tiny Plum having Eminent Potential of Copious Health Benefits
KR20210046999A (en) Cosmetic Composition For Improving Skin Elasticity Comprising Climbing Fig Extract As Active Ingredient
KR20090056522A (en) Cosmetic composition having free radical scavenging activity comprising the extract of citrus aurantium, hypericum sampsonii hance, taxillus chinensis, ligustrum lucidum, lycium chinense as active ingredient
KR101827531B1 (en) COSMETIC COMPOSITION FOR SKIN WHITENING CONTAINING Artemisia japonica Thunb. EXTRACTS AND PREPARING METHOD OF THE SAME
KR101890725B1 (en) A composition for antioxidation comprising extracts of sedirea japonica
KR102379994B1 (en) Antioxidative and antiaging composition containing the skin affinitive ingredients extracted from the flower stem of orchid callus
KR101695781B1 (en) A composition for antioxidating, whitening and improving wrinkle comprising extracts of nursery spiraea
KR102583415B1 (en) Cosmetic composition for improving skin elasticity comprising mixed extracts of phyllostachys nigra leaf extract and arctium lappa seed extract as active ingredients
KR101937751B1 (en) A method of manufacturing a paper mulberry extract using a paper mulberry stem

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right