KR102360053B1 - Fill-up lifting ampoule - Google Patents

Abstract

The present invention relates to a fill-up lifting ampoule. The fill-up lifting ampoule, according to the present invention, comprises: a solvent; a humectant; a viscosity increasing agent; a surfactant; a skin-conditioning agent; a pH adjuster; a fragrance ingredient; a film-former; and a colorant, wherein the skin-conditioning agent contains a kangaroo claw extract as an active ingredient. Accordingly, in the present invention, a composition including the kangaroo claw extract is used to produce an ampoule. Therefore, it is possible to produce a fill-up lifting ampoule which improves functions of face lifting and skin moisturization, reduces wrinkles around the eyes and nasolabial folds, increases skin density, and enhances the health of the skin.

Description

Fill-up lifting ampoule {FILL-UP LIFTING AMPOULE}

The present invention relates to a peel-up lifting ampoule, and more particularly, by preparing an ampoule using a composition containing a kangaroo claw extract, it improves facial lifting, skin moisturizing power, wrinkles around the eyes, nasolabial folds and skin density, etc. It relates to a peel-up lifting ampoule that can improve health.

In modern society, a large amount of active oxygen is generated due to ultraviolet rays and water pollution due to exhaust gas, harmful chemicals, and destruction of the ozone layer. It is known as the main cause.

In addition, in recent years, outdoor leisure activities such as golf are increasing in order to relieve excessive social and work stress. And skin aging is unavoidable, which negatively affects the trend of enjoying outdoor leisure activities more actively and comfortably.

In general, the skin plays a primary role in preventing harm from various external factors that impair the homeostasis of our body through basic metabolic processes. In other words, as the skin is located at the outermost part of the body, it performs various roles such as protection through physical, chemical and biological barrier functions, thermoregulation, sensory, secretion and excretion, absorption, storage, and regeneration. , most susceptible to damage when subjected to constant external stress.

The main causes of such external stress include UV exposure, exhaust gas, yellow dust, environmental pollutants, heavy metals, temperature changes, and microorganisms, which are mainly reactive oxygen species through oxidative stress. , ROS), disrupts the antioxidant defense system, causing cell damage and death.

In general, the phenomenon of skin wrinkling due to weakening of the elasticity and contractility of skin cells is caused by various causes, but it is widely known that skin aging is because the contraction and astringent action of the skin are reduced.

Skin aging is largely divided into intrinsic aging and extrinsic aging. Clinically, it is characterized by decreased elasticity, rough skin texture, deep wrinkles, and pigmentation.

In addition, external factor aging refers to an aging phenomenon caused by extrinsic factors such as ultraviolet rays, reactive oxygen species, and stress. Due to these factors, aging of the skin proceeds rapidly, and as a result, rough wrinkles are generated on the skin surface and elasticity is significantly reduced.

Various studies have been conducted to elucidate the aging mechanism of the skin as described above, and various causes of skin aging have been revealed by these studies. As the skin's physiological activity as a protective barrier is lowered, aging is accelerated, and when the skin is exposed to harmful active oxygen species or free radicals, lipid peroxide is generated by oxidation in the body, and various proteins constituting the skin are modified, causing the skin aging progresses.

This skin aging and elasticity decrease is caused by the decrease and destruction of collagen and elastin due to the weakening of skin cells (fibroblasts) caused by ultraviolet rays. Collagenase and Elastase are expressed in the skin by ultraviolet rays, etc., and these enzymes decompose normal collagen and elastin in the skin, resulting in a decrease in skin elasticity.

On the other hand, along with the rapid industrialization of modern society, the destruction of the ozone layer causes an increase in the amount of UV, which creates powerful oxidizing substances such as reactive oxygen species, and causes cell membrane and DNA damage, thereby accelerating skin aging. Furthermore, melanin produced as a defense material against oxidizing substances such as reactive oxygen species causes pigmentation to cause spots and freckles.

Therefore, since antioxidant activity is the most basic effect of protecting the skin, various antioxidants such as vitC, tocopherol, and coenzyme Q10 are used in the manufacture of cosmetics to protect the skin from various oxidizing substances.

Recently, it has been scientifically clarified that there are many physiologically active substances such as whitening, anti-aging, anti-wrinkle, and antioxidant in various plants, including herbal medicines and plant extracts, and various natural and herbal cosmetics using these have been developed.

Accordingly, the present inventors confirmed that by preparing an ampoule using a composition containing a kangaroo claw flower extract, it is possible to improve facial lifting, skin moisturizing power, eye wrinkles, nasolabial folds, and skin density, and improve skin health. The present invention was completed.

Domestic Registered Patent No. 10-2222365 (Registered on February 24, 2021) Domestic Registered Patent No. 10-1934281 (registered on December 26, 2018) Domestic Registered Patent No. 10-2050773 (Registered on November 26, 2019)

The present invention provides a peel-up lifting ampoule that can improve skin health and improve facial lifting, skin moisturizing power, eye wrinkles, nasolabial folds, and skin density by preparing an ampoule using a composition containing a kangaroo claw extract is doing

In addition, the present invention improves skin elasticity by promoting the synthesis of collagen, and by supplying nutrients to the skin, suppresses external stimuli such as ultraviolet rays and skin wrinkle formation due to skin aging, and cleanly removes dead skin cells and wastes in pores on the skin It aims to provide a peel-up lifting ampoule that can moisturize and smooth dry and dry skin while minimizing skin troubles and skin irritation.

Various problems to be solved by the present invention are not limited to the above-mentioned problems, and other problems not mentioned will be clearly understood by those skilled in the art from the following description.

The peel-up lifting ampoule according to the present invention is a solvent, a wetting agent, a viscosity increasing agent, a surfactant (Surfactants-Emulsifying Agent), a skin conditioning agent (Skin-Conditioning Agent), a pH adjuster (pH Adjuster) , fragrance (Fragrance Ingredient), a film former and a colorant (Colorant), the skin conditioning agent (Skin-Conditioning Agent) contains a kangaroo claw extract as an active ingredient, the kangaroo claw extract is kangaroo Using a claw flower extract, the kangaroo claw flower extract may contain 0.0005 to 0.003 parts by weight in the total content of the peel-up lifting ampoule composition, and the kangaroo claw flower extract is washed after preparing the kangaroo claw flower, and the washed kangaroo claw flower extract The flower is pulverized to have a particle diameter in the range of 100 to 3000 μm, and it can be prepared by extracting the pulverized kangaroo claw flower, and the solvent is 1,2-hexanediol (1,2-Hexanediol) and glycolic Acid (Glycolic Acid) is used, the humectant is purified water (Water), hydroxypropyltrimonium hyaluronate (Hydroxypropyltrimonium Hyaluronate) and palmitoyl tripeptide-1 (Palmitoyl Tripeptide-1) is used, the thickener is hydride Hydroxyethylcellulose and Carbomer are used, the surfactant is sodium hyaluronate, and the skin conditioning agent is Anigozanthos Flavidus Extract, niacinamide ( Niacinamide) (CAS. NO 98-92-0), Scutellaria Baicalensis Root Extract (CAS. NO 94279-99-9) ), Paeonia Suffruticosa Root Extract, Butylene Glycol (CAS. NO 107-88-0), Adenosine (CAS. NO 58-61-7), Polysorbate 20, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate Ronate (Potassium Hyaluronate), Sodium Acetylated Hyaluronate (Sodium Acetylated Hyaluronate), Hydrolyzed Hyaluronic Acid (CAS. NO 9004-61-9), Palmitoyltetrapeptide -7 (Palmitoyl Tetrapeptide-7), hyaluronic acid and sodium hyaluronate crosspolymer (CAS. NO 31799-91-4) are used, and the pH adjusting agent is glycerin ( Glycerin) is used, the fragrance is lavender water (Lavandula Angustifolia (Lavender) Water), the film former is used chitosan, and the pigment is Yellow No. 5 (CI 15985) (CAS. NO 221227) -05-0) or Yellow No. 4 (CI 19140) (CAS. NO 9067-32-7) can be used.

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The 1,2-hexanediol (1,2-Hexanediol) 1.5 to 2.5 parts by weight, glycolic acid (Glycolic Acid) 0.5 to 1.5 parts by weight, purified water (Water) 0.3 to 0.9 parts by weight, hydroxypropyltrimonium high Aluronate (Hydroxypropyltrimonium Hyaluronate) 0.00005 to 0.0002 parts by weight, Palmitoyl Tripeptide-1 (Palmitoyl Tripeptide-1) 0.000005 to 0.00002 parts by weight, Hydroxyethylcellulose (Hydroxyethylcellulose) 0.1 to 0.3 parts by weight, Carbomer (Carbomer) 0.0005 To 0.002 parts by weight, Sodium Hyaluronate 0.0005 to 0.002 parts by weight, Anigozanthos Flavidus Extract 0.0005 to 0.003 parts by weight, Niacinamide 1-3 parts by weight, Golden extract (Scutellaria) Baicalensis Root Extract) 0.3 to 0.7 parts by weight, Paeonia Suffruticosa Root Extract 0.3 to 0.7 parts by weight, Butylene Glycol 0.2 to 0.5 parts by weight, Adenosine 0.01 to 0.07 parts by weight, Poly 0.0001 to 0.001 parts by weight of Polysorbate 20, 0.0000005 to 0.0000015 parts by weight of Hydrolyzed Sodium Hyaluronate, 0.0000001 to 0.0000003 parts by weight of Potassium Hyaluronate, Sodium Acetyl Sodium Acetylated Hyaluronate 0.000005 to 0.00005 parts by weight, Hydrolyzed Hyaluronic Acid 0.0000 05 to 0.00005 parts by weight, Palmitoyl Tetrapeptide-7 0.000001 to 0.00001 parts by weight, Hyaluronic Acid 0.000001 to 0.000003 parts by weight, Sodium Hyaluronate Crosspolymer ) 0.0000005 to 0.000002 parts by weight, Glycerin 0.5 to 1.2 parts by weight, Lavandula Angustifolia (Lavender) Water 85 to 95 parts by weight, Chitosan 0.5 to 1.5 parts by weight, Yellow No. 5 (CI 15985) 0.0001 to 0.001 parts by weight and 0.0001 to 0.001 parts by weight of Yellow No. 4 (CI 19140) may be included.

The 1,2-hexanediol (1,2-Hexanediol) 1.857 parts by weight, glycolic acid (Glycolic Acid) 1.05 parts by weight, purified water (Water) 0.6 parts by weight, hydroxypropyltrimonium hyaluronate (Hydroxypropyltrimonium Hyaluronate) ) 0.0001 parts by weight, Palmitoyl Tripeptide-1 0.00001 parts by weight, Hydroxyethylcellulose 0.2 parts by weight, Carbomer 0.001 parts by weight, Sodium Hyaluronate 0.001 parts by weight, Anigozanthos Flavidus Extract 0.002 parts by weight, Niacinamide 2 parts by weight, Scutellaria Baicalensis Root Extract 0.5 parts by weight, Paeonia Suffruticosa Root Extract 0.5 parts by weight , Butylene Glycol 0.32 parts by weight, Adenosine 0.04 parts by weight, Polysorbate 20 0.0005 parts by weight, Hydrolyzed Sodium Hyaluronate 0.000001 parts by weight , Potassium Hyaluronate 0.0000002 parts by weight, Sodium Acetylated Hyaluronate 0.00001 parts by weight, Hydrolyzed Hyaluronic Acid 0.00001 parts by weight, Palmi Palmitoyl Tetrapeptide-7 0.000005 parts by weight, Hyaluronic Acid 0.0000025 parts by weight, Sodium Hyaluronate Crosspolymer 0.0000 01 parts by weight, 0.83 parts by weight of Glycerin, 90.87 parts by weight of Lavandula Angustifolia (Lavender) Water, 1.23 parts by weight of Chitosan, 0.0005 parts by weight of Yellow No. 5 (CI 15985), and 0.0005 parts by weight of Yellow No. 4 (CI) 19140) 0.0005 parts by weight.

Specific details of other embodiments are included in the detailed description.

The present invention manufactures a peel-up lifting ampoule that can improve facial lifting, skin moisturizing, eye wrinkles, nasolabial folds and skin density, etc. and improve skin health by preparing an ampoule using a composition containing a kangaroo claw extract can do.

In addition, the peel-up lifting ampoule according to the present invention improves skin elasticity by promoting the synthesis of collagen, and by supplying nutrients to the skin, it suppresses external stimuli such as ultraviolet rays and the generation of skin wrinkles due to skin aging, keratin and pores on the skin It can cleanly remove wastes inside, minimize skin troubles and skin irritation, and make dry and dry skin moist and smooth.

It will be fully understood that embodiments of the technical idea of the present invention may provide various effects not specifically mentioned.

1A is a photograph showing the eye area of a subject before using the peel-up lifting ampoule prepared according to the example, and FIG. This is a photograph showing the subject's eye area after the treatment.
Figure 2a is a photograph showing the nasolabial folds around the subject's mouth before using the peel-up lifting ampoule prepared according to the embodiment, and Figure 2b is the peel-up lifting ampoule prepared according to the embodiment applied to the nasolabial folds around the mouth of the subject This is a photograph showing the area of the nasolabial folds around the subject's mouth after 4 weeks of use.
3A is a photograph showing the subject's chin before using the peel-up lifting ampoule prepared according to the example, and FIG. 3B is a photograph showing the subject's chin before using the peel-up lifting ampoule prepared according to the example. This is a photograph showing the subject's chin after the treatment.
Figure 4a is a photograph showing the subject's face before using the peel-up lifting ampoule prepared according to the embodiment, Figure 4b is a peel-up lifting ampoule prepared according to the embodiment is applied to the subject's face After 4 weeks have elapsed A photograph showing the subject's face.
Figure 5a is a photograph showing the skin (face) moisturizing power of the subject before using the peel-up lifting ampoule prepared according to the embodiment, and Figure 5b is the peel-up lifting ampoule prepared according to the embodiment is applied to the skin (face) of the subject This is a photograph showing the skin (face) moisturizing power of the subject after 4 weeks of use.
Figure 6a is a photograph showing the skin (face) density of the subject before using the peel-up lifting ampoule prepared according to the embodiment, Figure 5b is the peel-up lifting ampoule prepared according to the embodiment is applied to the skin (face) of the subject This is a photograph showing the density of the skin (face) of the subject after 4 weeks of use.

Advantages and features of the present invention, and methods for achieving them, will become apparent with reference to the embodiments described below in detail. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the embodiments introduced herein are provided so that the disclosed subject matter may be thorough and complete, and that the spirit of the present invention may be sufficiently conveyed to those skilled in the art.

The terms used in the present application are only used to describe specific embodiments, and are not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly dictates otherwise.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries should be interpreted as having meanings consistent with the meanings in the context of the related art, and should not be interpreted in an ideal or excessively formal meaning unless explicitly defined in the present application. does not

Hereinafter, a preferred embodiment of the peel-up lifting ampoule according to the present invention will be described in detail.

The peel-up lifting ampoule according to the present invention contains kangaroo claw extract as an active ingredient as a skin-conditioning agent.

The kangaroo claw extract can be prepared by extracting kangaroo claws ( Anigozanthos flavidus ), and the kangaroo claw ( Anigozanthos flavidus ) is a perennial grass of monocotyledonous plants. , is native to Western Australia, and is distributed in South Africa, Australia, New Guinea, and tropical South America, and inhabits dry sand, gravel fields, wetlands, and around drainage channels.

In the kangaroo claw, the rhizome extends sideways, the diameter reaches 50 cm, there is no main stem, and up to 10 flower stems come up together with the leaves, the length is about 1-1.5 m, and the flower branches are split at the upper part. Flower stalks grow to about 0.5-1.5 m in height.

The kangaroo claw extract can control both the stability of collagen and elastin, organize collagen fibers in the extracellular matrix (ECM) to enhance the stiffness or elasticity of almost all cells in the body, and reconstruct the structure of the skin over time. It is known that it can help reduce wrinkles on the eyes and neck as well as sagging skin.

The kangaroo claw extract may be prepared by extracting any one or more selected from flowers, leaves, or stems of kangaroo claws, and preferably, a kangaroo claw flower extract prepared by extracting flowers of kangaroo claws may be used, for example, , The kangaroo claw flower extract may be a kangaroo claw flower extract prepared by the following method.

In order to prepare the kangaroo claw flower extract, first, the kangaroo claw flower may be prepared and then washed.

Next, the washed kangaroo claw flowers may be pulverized to a certain particle size.

In the above step, the active ingredient of the kangaroo claw flower can be effectively extracted by pulverizing the washed kangaroo claw flower to a certain particle size. It can be crushed to become

When the particle diameter of the washed kangaroo claw flower is pulverized to less than 100 μm in the above step, it takes a long time to pulverize, and the particles are too small to cause agglomeration between the particles in a later process, and the particle diameter exceeds 3000 μm When it is pulverized, it may be difficult to effectively extract useful ingredients from the kangaroo claw flower in a short time.

Then, the pulverized kangaroo claw flower may be extracted to prepare a kangaroo claw flower extract.

Extraction of the pulverized kangaroo claw flower in the above step may be performed using a variety of known extraction methods such as hot water extraction, organic solvent extraction, ultrasonic extraction, and supercritical extraction.

For example, the ultrasonic extraction method is an extraction solvent for the sample, which is water, C1-C6 anhydrous or hydrous lower alcohol, acetone, butylene glycol, ethyl acetate, diethyl acetate, diethyl ether, benzene, chloroform and a group consisting of hexane After adding any one or more extraction solvents selected from 10 to 20 times by volume, it may mean an extraction method performed using an ultrasonic extraction method for 1 hour to 10 hours, preferably 1 hour to 4 hours.

In addition, the supercritical extraction method is a supercritical fluid extraction reactor (Natex, Autstria) in 500-700 mL of ethanol (99.5%) as an auxiliary solvent with the pulverized kangaroo claw flower, the temperature in the reactor is 65 ℃, the pressure is 450 bar, S/F ratio (supercritical fluid kg/Feed kg) may refer to a method of extraction under the condition of 35.

In addition, the peel-up lifting ampoule according to the present invention is a solvent, a wetting agent, a viscosity increasing agent, a surfactant (Surfactants-Emulsifying Agent), a skin conditioning agent (Skin-Conditioning Agent), a pH adjusting agent (pH) Adjuster), a fragrance (Fragrance Ingredient), a film former (Film Former) and a colorant (Colorant).

The solvent is used to increase moisture and moisturizing power, and can be used to effectively dissolve various compositions included in the peel-up lifting ampoule. The solvent is 1,2-hexanediol (1,2-Hexanediol) ( CAS. NO 6920-22-5) and Glycolic Acid (CAS. NO 7732-18-5) can be used.

In addition, in the present invention, the solvent (Solvent) is 1.5 to 2.5 parts by weight of the 1,2-hexanediol (1,2-Hexanediol) in the total content of the peel-up lifting ampoule composition, the glycolic acid (Glycolic Acid) 0.5 to 1.5 parts by weight may be included.

The humectant may be included to absorb or preserve moisture to enhance moisturizing power, and the humectant includes purified water (CAS. NO 56-81-5), hydroxypropyltrimonium hyaluronate ( Hydroxypropyltrimonium Hyaluronate) and palmitoyl tripeptide-1 may be used.

In addition, in the present invention, as for the humectant, 0.3 to 0.9 parts by weight of the purified water is included in the total content of the peel-up lifting ampoule composition, and hydroxypropyltrimonium hyaluronate is 0.00005 to 0.0002 by weight The addition may be included, and 0.000005 to 0.00002 parts by weight of palmitoyl tripeptide-1 may be included.

The thickener (Viscosity Increasing Agent) may be included to increase or control the viscosity of the peel-up lifting ampoule, and the thickener includes hydroxyethylcellulose (CAS. NO 9004-62-0) and carbomer. (Carbomer) (CAS. NO 9003-01-04) can be used.

In addition, in the present invention, as for the thickener (Viscosity Increasing Agent), in the total content of the peel-up lifting ampoule composition, 0.1 to 0.3 parts by weight of the hydroxyethylcellulose is included, and 0.0005 to 0.002 parts by weight of the carbomer may be included. have.

The surfactant (Surfactants-Emulsifying Agent) is included to provide functionality in the peel-up lifting ampoule, and acts as an emulsifier or solubilizer, and may be included to maintain the dispersed state of the peel-up lifting ampoule composition. As the surfactant, sodium hyaluronate (CAS. NO 9005-64-5) may be used.

In addition, in the present invention, the surfactant (Surfactants-Emulsifying Agent) may include 0.0005 to 0.002 parts by weight of the sodium hyaluronate in the total content of the peel-up lifting ampoule composition.

The skin-conditioning agent may be included to improve the functionality and cosmetic effect of the peel-up lifting ampoule, and to enhance the effects of nutrition, soothing/trouble improvement, and whitening. (Anigozanthos Flavidus Extract), Niacinamide (CAS. NO 98-92-0), Scutellaria Baicalensis Root Extract (CAS. NO 94279-99-9), Peony Root Extract (Paeonia Suffruticosa Root Extract) , Butylene Glycol (CAS. NO 107-88-0), Adenosine (CAS. NO 58-61-7), Polysorbate 20, Hydrolyzed Sodium High Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Hyaluronic Acid (CAS. NO 9004-61-9), Palmitoyl Tetrapeptide-7, Hyaluronic Acid and Sodium Hyaluronate Crosspolymer (CAS. NO 31799-91) -4) can be used.

In addition, in the present invention, the skin-conditioning agent (Skin-Conditioning Agent) contains 0.0005 to 0.003 parts by weight of the kangaroo claw flower extract (Anigozanthos Flavidus Extract) in the total content of the peel-up lifting ampoule composition, and niacinamide is 1 to 3 parts by weight is included, golden extract (Scutellaria Baicalensis Root Extract) is included in 0.3 to 0.7 parts by weight, peony root extract (Paeonia Suffruticosa Root Extract) is included in 0.3 to 0.7 parts by weight, butylene Glycol is 0.2 to 0.5 parts by weight is included, adenosine is included in 0.01 to 0.07 parts by weight, polysorbate 20 is included in 0.0001 to 0.001 parts by weight, and hydrolyzed sodium hyaluronate (Hydrolyzed Sodium) Hyaluronate) is included in 0.0000005 to 0.0000015 parts by weight, potassium hyaluronate is included in 0.0000001 to 0.0000003 parts by weight, and sodium acetylated hyaluronate is included in 0.000005 to 0.00005 parts by weight. , Hydrolyzed Hyaluronic Acid contains 0.000005 to 0.00005 parts by weight, Palmitoyl Tetrapeptide-7 contains 0.000001 to 0.00001 parts by weight, hyaluronic acid (Hyaluronic Acid) is included in 0.000001 to 0.000003 parts by weight, and sodium hyaluronate crosspolymer (Sodium Hyaluronate Crosspolymer) may be included in 0.0000005 to 0.000002 parts by weight.

The pH adjuster is included to adjust the final pH of the peel-up lifting ampoule within the range stipulated in the cosmetic regulations, and as the pH adjuster, glycerin (CAS. NO 79-14-1) is can be used

In addition, in the present invention, the pH adjuster may include 0.5 to 1.2 parts by weight of the glycerin in the total content of the peel-up lifting ampoule composition.

The fragrance (Fragrance Ingredient) may be included to add a fragrance to increase the preference of the peel-up lifting ampoule, and as the fragrance, lavender water (Lavandula Angustifolia (Lavender) Water) may be used.

In addition, in the present invention, the fragrance (Fragrance Ingredient) may include 85 to 95 parts by weight of the lavender water (Lavandula Angustifolia (Lavender) Water) in the total content of the peel-up lifting ampoule composition.

The film former is mixed with the compositions included in the peel-up lifting ampoule to form a film, thereby protecting the composition included in the peel-up lifting ampoule and at the same time, the effect of the peel-up lifting ampoule can last for a long time. It may be included, the film forming agent may be used chitosan (Chitosan) (CAS. NO 9012-76-4).

In addition, in the present invention, the film former may contain 0.5 to 1.5 parts by weight of the chitosan in the total content of the peel-up lifting ampoule composition.

The colorant may be included to impart color to the peel-up lifting ampoule, and the colorant is Yellow No. 5 (CI 15985) (CAS. NO 221227-05-0) or Yellow No. 4 (CI 19140) (CAS). .NO 9067-32-7) may be used.

In addition, in the present invention, as for the colorant, in the total content of the peel-up lifting ampoule composition, 0.0001 to 0.001 parts by weight of Yellow No. 5 (CI 15985), and 0.0001 to 0.001 parts by weight of Yellow No. 4 (CI 19140) may be included. have.

In addition, the peel-up lifting ampoule according to the present invention may further include green-lipped mussel oil and seoritae black bean extract to enhance cosmetic effects and prevent skin aging and inflammation. Mussel oil may contain 0.00001 to 0.00005 parts by weight, and the Seoritae black bean extract may contain 0.00002 to 0.00006 parts by weight.

The green-lipped mussel oil is manufactured using green-lipped mussels (Perna Canaliculus), which is a kind of mussels that inhabit the coast of New Zealand and is called green-lipped mussel, and its scientific name is Perna. Canaliculus.

It has been reported that the green-lipped mussel contains omega unsaturated fatty acids related to antioxidant and anti-inflammatory properties, that is, a unique component that cannot be seen in mussels that are native to other regions, because the green-lipped mussel feeds mainly on plankton that has evolved to resist intense ultraviolet rays.

In addition, the unsaturated fatty acids found in the green lipped mussel have been known through clinical trials to have a 200-fold stronger anti-inflammatory effect than fish oil, linseed oil, evening primrose oil, and the like containing omega-3 fatty acids. Omega-3 fatty acids have been found to inhibit the occurrence of inflammatory diseases such as atherosclerosis and rheumatoid arthritis by interfering with the production of inflammatory mediators made from omega-6 fatty acids by competing with omega-6 linoleic acid. there is a bar

In the present invention, green-lipped mussel oil prepared by the following method may be used as the green-lipped mussel oil.

First, the skin of the green-lipped mussel may be removed, and the green-lipped mussel from which the skin has been removed may be washed.

In the above step, the green-lipped mussel from which the skin has been removed can be washed with a sodium bicarbonate solution having a temperature of 10 to 20° C. and a concentration range of 1 to 3 (w/w)%, and the sodium bicarbonate (NaHCO3) is a food product. It is also used as an additive, is non-toxic, and may have functions such as penetration, diffusion, and expansion.

Next, the washed green-lipped mussels may be dried.

Drying of the washed green-lipped mussel may consist of a first drying and a second drying, wherein the first drying is performed by drying the washed green-lipped mussel at a temperature of 70 to 80° C. for 3 to 5 hours. Residual moisture in green-lipped mussels can be removed primarily.

In addition, in the second drying, the first dried green-lipped mussel may be dried with hot air, and the second drying is performed by applying hot air to the first dried green-lipped mussel at a temperature of 110 to 130° C. for 1 to 3 hours. This can be done by adding

Next, the second dried green-lipped mussel can be pulverized and then aged to prepare an aged green-lipped mussel powder.

In the above step, the grinding of the second dried green-lipped mussel is pulverized by pulverizing the second dried green-lipped mussel to a particle size of 5 to 10 mm, and the aging of the powdered green-lipped mussel is the powdered green mussel. It can be carried out by storing the lipped mussels at a temperature of 5 to 10° C. for 3 to 7 hours.

Then, the green-lipped mussel aged powder can be enzymatically decomposed by mixing the enzyme and acid and storing the mixture.

That is, in the above step, the enzyme and acid are mixed in the aged powder of green lipped mussel, and then the aged powder of green lipped mussel in which the enzyme and acid are mixed is stored at a temperature of 36 to 38° C. for 20 to 30 hours, thereby enzymatic decomposition. .

In the above step, known commercially available protease (Protease), chitinase (chitinase), pectinase (Pectinase) and xylanase (Xylanase) are used as the enzyme, and citric acid and ascortic acid are used as the acid. Binic acid may be used, specifically, 0.01 to 0.03 parts by weight of the protease, 0.03 to 0.05 parts by weight of the chitinase, and pectinase based on 100 parts by weight of the whole aged powder of green lipped mussel. 0.005 to 0.009 parts by weight, 0.008 to 0.012 parts by weight of Xylanase, 0.01 to 0.1 parts by weight of citric acid, and 0.01 to 0.1 parts by weight of ascorbic acid may be mixed in a weight ratio.

Next, the fermented green-lipped mussel can be prepared by mixing the lactic acid bacteria culture solution with the enzyme-decomposed green-lipped mussel aged powder and fermenting it.

In the above step, after mixing in a weight ratio of 1 to 3 parts by weight of the lactic acid bacteria culture solution to 100 parts by weight of the enzymatically decomposed green-lipped mussel aged powder, fermentation may be performed at a temperature of 40 to 42° C. for 20 to 30 hours.

In addition, in the above step, the lactic acid bacteria culture medium was adjusted to pH 2.8 to 3.2 using 1.2N HCl, and then the lactic acid strain was separated from kimchi, and the separated lactic acid strain was used in MRS broth (Oxoid, England). After culturing at 37-39°C for 20-25 hours, dilute to 1×1.0 ^8-5 ×1.0 ⁸ CFU/mL, and then centrifuge at 10,000-15,000 rpm for 10-15 minutes to separate only the supernatant And, after filtering the supernatant (Supernatant) with a 0.45㎛ syringe filter (syringe filter), mixed in a weight ratio of 1,000 to 2,000 parts by weight of sterilized distilled water with respect to 100 parts by weight of the filtered supernatant It is prepared by diluting, the lactic acid bacteria As a lactic acid strain isolated from fermented food, kimchi, specifically, the lactic acid strain includes Lactobacillus curvatus , Weissella viridescens , Lactobacillus plantarum ) and Any one or more known lactic acid strains selected from the group consisting of Leuconostoc lactis may be used.

Next, the green-lipped mussel oil can be prepared by separating the oil using the fermented green-lipped mussel.

The configuration, such as separating the oil using the green-lipped mussel fermented product in the above step, is a known technique to those of ordinary skill in the art, and for convenience of explanation and clarity of the technical idea of the present invention, A detailed description thereof will be omitted.

The Seoritae black soybean extract is prepared using black soybeans from Seoritae. In general, black beans belong to the leguminosae and are a generic term for black beans and belong to Heuktae, Seoritae, and Seomoktae family. Glycine max (L) Merr, Seoritate soybean, one of the black beans, is a soybean with a black skin and yellow inside, and is the largest of all black beans.

The Seoritae is composed of 8.9% water, 25.3% sugar, 42.3% crude protein, 19.0% crude fat, and 4.5% ash, and contains a large amount of cysteine, an essential ingredient, and contains lecithin, phytoestrogens, unsaturated fatty acids, anthocyanins, etc. has been

As the efficacy of Seoritae, it has antioxidant, anticancer, antiobesity, immunomodulatory, and thrombogenesis inhibitory effects, and in particular, it is reported that Seoritae has a high content of glycitein, isoflavones, anthocyanins, and polyphenols.

The Seoritae black soybean extract may be used as the Seoritae black soybean extract prepared by the following method.

First, in order to prepare a seoritae black bean extract, it is possible to remove foreign substances by washing after preparing the excellent quality seoritae black bean extract.

For example, in the above step, it is possible to remove foreign substances attached to the black soybeans in Seoritae by washing the prepared black beans with purified water and removing the non-edible parts.

Next, it is possible to remove the moisture remaining inside the Seoritae black beans by drying the washed black beans first.

In the above step, the moisture contained inside the washed Seoritae black beans is rapidly evaporated when drying in sunlight, and may be performed in a dryer or shade, etc. to prevent deterioration of physical properties, for example, the washed Seoritae black beans The primary drying of beans may be carried out by drying the black beans in Seoritae by storing them at a temperature of 15 to 25° C. for 80 to 120 hours.

Next, the first dried Seoritae black beans can be dried by hot air.

In the above step, the primarily dried Seoritae black beans may be dried with hot air at 110 to 150° C. for 1 to 3 hours. When the hot air drying is performed below the lower limit, the moisture inside There may be a problem that this is not sufficiently removed, and when it is performed in excess of the above-mentioned upper limit range, the problem of deterioration of physical properties may occur due to excessive drying of seoritae black beans.

Then, the hot air dried Seoritae black beans can be heated and baked and roasted.

In the above step, the hot air-dried Seoritae black beans may be baked using a roasting device, and the step may be performed by baking the hot-air dried Seoritae black beans at a temperature of 110 to 130° C. for 5 to 10 minutes. .

Next, the roasted Seoritae black beans may be dried a second time.

In the above step, the physical properties of the roasted Seoritae black beans can be stabilized by drying the roasted Seoritae black beans a second time, and the secondary drying of the roasted Seoritae black beans is 15 to 25° C. It can be carried out by drying at a temperature of 1 to 3 days.

Next, by pulverizing the secondly dried black beans in Seoritae, it is possible to prepare a powder of black beans in Seoritae.

The grinding of the secondly dried Seoritae black beans in the above step can be performed using a known grinder, and the configuration of grinding using the grinder is a known technique, so that convenience of explanation and clarity of the technical idea of the present invention can be improved. For this purpose, a detailed description thereof will be omitted.

Then, the seoritae black bean powder can be extracted to prepare a seoritae black bean extract.

In the above step, the extraction of the black soybean powder from Seoritae may be performed using a variety of known extraction methods such as hot water extraction, organic solvent extraction, ultrasonic extraction, and supercritical extraction.

For example, the ultrasonic extraction method is an extraction solvent for the sample, which is water, C1-C6 anhydrous or hydrous lower alcohol, acetone, butylene glycol, ethyl acetate, diethyl acetate, diethyl ether, benzene, chloroform and a group consisting of hexane After adding any one or more extraction solvents selected from 10 to 20 times by volume, it may mean an extraction method performed using an ultrasonic extraction method for 1 hour to 10 hours, preferably 1 hour to 4 hours.

In addition, the supercritical extraction method is the Seoritae black soybean powder and ethanol (99.5%) 500 ~ 700mL as an auxiliary solvent put into a supercritical fluid extraction reactor (Natex, Autstria), the temperature in the reactor is 65 ℃, the pressure is 450 bar, S It may refer to a method of extraction under the condition that /F ratio (supercritical fluid kg/Feed kg) becomes 35.

Hereinafter, an embodiment of the peel-up lifting ampoule according to the present invention will be described in more detail with reference to the accompanying drawings.

<Example>

1,2-hexanediol (1,2-Hexanediol) 1.857 parts by weight, glycolic acid 1.05 parts by weight, purified water (Water) 0.6 parts by weight, hydroxypropyltrimonium hyaluronate (Hydroxypropyltrimonium Hyaluronate) 0.0001 parts by weight, Palmitoyl Tripeptide-1 0.00001 parts by weight, Hydroxyethylcellulose 0.2 parts by weight, Carbomer 0.001 parts by weight, Sodium Hyaluronate 0.001 Parts by weight, Anigozanthos Flavidus Extract 0.002 parts by weight, Niacinamide 2 parts by weight, Scutellaria Baicalensis Root Extract 0.5 parts by weight, Paeonia Suffruticosa Root Extract 0.5 parts by weight, 0.32 parts by weight of Butylene Glycol, 0.04 parts by weight of Adenosine, 0.0005 parts by weight of Polysorbate 20, 0.000001 parts by weight of Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate 0.0000002 parts by weight, Sodium Acetylated Hyaluronate 0.00001 parts by weight, Hydrolyzed Hyaluronic Acid 0.00001 parts by weight, Palmitoyl Tetrapeptide-7 (Palmitoyl Tetrapeptide-7) 0.000005 parts by weight, Hyaluronic Acid 0.0000025 parts by weight, Sodium Hyaluronate Crosspolymer 0.000001 Parts by weight, Glycerin 0.83 parts by weight, Lavandula Angustifolia (Lavender) Water 90.87 parts by weight, Chitosan 1.23 parts by weight, Yellow No. 5 (CI 15985) 0.0005 parts by weight, and Yellow No. 4 (CI 19140) ) A peel-up lifting ampoule containing 0.0005 parts by weight was prepared.

An experiment was performed to confirm the effect of the peel-up lifting ampoule prepared according to the above example, and the experiment was performed at the KC Skin Clinical Research Center.

1. Evaluation of wrinkles around the eyes

The peel-up lifting ampoule prepared according to the example was applied to the subject's eye area once a day in a certain amount and used, and after 4 weeks had elapsed, the degree of improvement in the depth of wrinkles around the eyes and wrinkles around the eyes was tested.

1A is a photograph showing the eye area of a subject before using the peel-up lifting ampoule prepared according to the example, and FIG. This is a photograph showing the subject's eye area after the treatment.

1A and 1B, after 4 weeks have elapsed after applying the peel-up lifting ampoule prepared according to the embodiment to the eye area of the subject, the wrinkles around the eyes are improved by 4.018%, and the depth of the wrinkles around the eyes is improved by 7.8949% it has been confirmed that

2. Evaluation of improvement of nasolabial folds

The peel-up lifting ampoule prepared according to the example was applied by applying a certain amount to the nasolabial folds around the mouth of the subject once a day and used, and after 4 weeks, the degree of improvement of the wrinkle depth in the nasolabial folds around the mouth was tested.

Figure 2a is a photograph showing the nasolabial folds around the subject's mouth before using the peel-up lifting ampoule prepared according to the embodiment, and Figure 2b is the peel-up lifting ampoule prepared according to the embodiment is applied to the nasolabial folds around the mouth of the subject This is a photograph showing the area of the nasolabial folds around the subject's mouth after 4 weeks of use.

Referring to FIGS. 2A and 2B , it was confirmed that the depth of the nasolabial folds was improved by 11.0722% after 4 weeks of using the peel-up lifting ampoule prepared according to the embodiment by applying it to the nasolabial folds around the mouth of the subject.

3. Double chin improvement evaluation

The peel-up lifting ampoule prepared according to the example was applied by applying a certain amount to the subject's chin once daily, and after 4 weeks had elapsed, the degree of double chin lifting and skin elasticity improvement in the chin area was tested.

3A is a photograph showing the subject's chin before using the peel-up lifting ampoule prepared according to the example, and FIG. 3B is a photograph showing the subject's chin before using the peel-up lifting ampoule prepared according to the example. This is a picture showing the subject's chin after the treatment.

Referring to FIGS. 3A and 3B , after 4 weeks of using the peel-up lifting ampoule prepared according to the example to be applied to the subject's chin, the double chin lifting was improved by 0.874%, and the skin elasticity was improved by 3.1634%. This was confirmed.

4. Evaluation of Facial Lifting Improvements

The peel-up lifting ampoule prepared according to the example was applied by applying a certain amount to the subject's chin once daily, and the degree of improvement in facial lifting was tested after 4 weeks had elapsed.

Figure 4a is a photograph showing the subject's face before using the peel-up lifting ampoule prepared according to the embodiment, Figure 4b is a peel-up lifting ampoule prepared according to the embodiment is applied to the subject's face After 4 weeks have elapsed A photograph showing the subject's face.

4A and 4B , it was confirmed that the face lifting angle was improved by 1.403% after 4 weeks of using the peel-up lifting ampoule prepared according to the embodiment by applying it to the subject's face.

5. Evaluation of skin moisture improvement

The peel-up lifting ampoule prepared according to the example was applied to the skin (face) of the subject once a day in a certain amount and used, and the degree of improvement in skin moisturizing power was tested after 4 weeks had elapsed.

Figure 5a is a photograph showing the skin (face) moisturizing power of the subject before using the peel-up lifting ampoule prepared according to the embodiment, and Figure 5b is a peel-up lifting ampoule prepared according to the embodiment is applied to the skin (face) of the subject This is a photograph showing the skin (face) moisturizing power of the subject after 4 weeks of use.

Referring to FIGS. 5A and 5B , it was confirmed that the skin moisturizing power was improved by 36.521% after 4 weeks of using the peel-up lifting ampoule prepared according to the example by applying it to the skin (face) of the subject.

6. Evaluation of skin density improvement

The peel-up lifting ampoule prepared according to the example was applied to the skin (face) of the subject once a day in a certain amount and used, and the degree of improvement in skin density was tested after 4 weeks had elapsed.

Figure 6a is a photograph showing the skin (face) density of the subject before using the peel-up lifting ampoule prepared according to the embodiment, Figure 5b is a peel-up lifting ampoule prepared according to the embodiment is applied to the skin (face) of the subject This is a photograph showing the density of the skin (face) of the subject after 4 weeks of use.

6A and 6B , it was confirmed that the skin density was improved by 5.454% after 4 weeks of using the peel-up lifting ampoule prepared according to the example by applying it to the skin (face) of the subject.

As described above, a preferred embodiment of the present invention has been described, but those of ordinary skill in the art to which the present invention pertains will understand that the present invention may be embodied in other specific forms without changing the technical spirit or essential features thereof. will be able Therefore, it should be understood that the embodiment described above is illustrative in all respects and not restrictive.

Claims (6)

Solvent, Humectant, Viscosity Increasing Agent, Surfactants-Emulsifying Agent, Skin-Conditioning Agent, pH Adjuster, Fragrance Ingredient, Film Containing a former (Film Former) and a colorant (Colorant),
The skin conditioning agent (Skin-Conditioning Agent) contains kangaroo claw extract as an active ingredient,
The kangaroo claw extract uses a kangaroo claw flower extract, and the kangaroo claw flower extract contains 0.0005 to 0.003 parts by weight in the total content of the peel-up lifting ampoule composition,
The kangaroo claw flower extract is prepared by washing the kangaroo claw flower after preparing it, pulverizing the washed kangaroo claw flower to have a particle size in the range of 100 to 3000 μm, and extracting the pulverized kangaroo claw flower,
As the solvent, 1,2-hexanediol and glycolic acid are used, and the wetting agent is purified water, hydroxypropyltrimonium hyaluronate and Palmitoyl tripeptide-1 is used, the thickener is hydroxyethylcellulose and carbomer is used, and the surfactant is sodium hyaluronate. The skin conditioning agent is kangaroo claw flower extract (Anigozanthos Flavidus Extract), niacinamide (Niacinamide) (CAS. NO 98-92-0), golden extract (Scutellaria Baicalensis Root Extract) (CAS. NO 94279-99-9) ), Peony Root Extract (Paeonia Suffruticosa Root Extract), Butylene Glycol (CAS. NO 107-88-0), Adenosine (CAS. NO 58-61-7), Polysorbate 20 (Polysorbate 20), Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Hyaluronate Hydrolyzed Hyaluronic Acid (CAS. NO 9004-61-9), Palmitoyl Tetrapeptide-7, Hyaluronic Acid and Sodium Hyaluronate Crosspolymer ( Sodium Hyaluronate Crosspolymer) (CAS. NO 31799-91-4) is used, and glycerin is used as the pH adjusting agent, and the Lavender water (Lavandula Angustifolia (Lavender) Water) is used as a fragrance, chitosan (Chitosan) is used as the film forming agent, and the pigment is Yellow No. 5 (CI 15985) (CAS. NO 221227-05-0) or Yellow No. 4 (CI 19140) (CAS. NO 9067-32-7) is a peel-up lifting ampoule, characterized in that it is used.
delete delete delete The method of claim 1,
The 1,2-hexanediol (1,2-Hexanediol) 1.5 to 2.5 parts by weight, glycolic acid (Glycolic Acid) 0.5 to 1.5 parts by weight, purified water (Water) 0.3 to 0.9 parts by weight, hydroxypropyltrimonium high Aluronate (Hydroxypropyltrimonium Hyaluronate) 0.00005 to 0.0002 parts by weight, Palmitoyl Tripeptide-1 0.000005 to 0.00002 parts by weight, Hydroxyethylcellulose 0.1 to 0.3 parts by weight, Carbomer 0.0005 To 0.002 parts by weight, Sodium Hyaluronate 0.0005 to 0.002 parts by weight, Anigozanthos Flavidus Extract 0.0005 to 0.003 parts by weight, Niacinamide 1-3 parts by weight, Golden extract (Scutellaria) Baicalensis Root Extract) 0.3 to 0.7 parts by weight, Paeonia Suffruticosa Root Extract 0.3 to 0.7 parts by weight, Butylene Glycol 0.2 to 0.5 parts by weight, Adenosine 0.01 to 0.07 parts by weight, Poly 0.0001 to 0.001 parts by weight of Polysorbate 20, 0.0000005 to 0.0000015 parts by weight of Hydrolyzed Sodium Hyaluronate, 0.0000001 to 0.0000003 parts by weight of Potassium Hyaluronate, Sodium Acetyl Sodium Acetylated Hyaluronate 0.000005 to 0.00005 parts by weight, Hydrolyzed Hyaluronic Acid 0.0000 05 to 0.00005 parts by weight, Palmitoyl Tetrapeptide-7 0.000001 to 0.00001 parts by weight, Hyaluronic Acid 0.000001 to 0.000003 parts by weight, Sodium Hyaluronate Crosspolymer ) 0.0000005 to 0.000002 parts by weight, Glycerin 0.5 to 1.2 parts by weight, Lavandula Angustifolia (Lavender) Water 85 to 95 parts by weight, Chitosan 0.5 to 1.5 parts by weight, Yellow No. 5 (CI 15985) Peel-up lifting ampoule, characterized in that it contains 0.0001 to 0.001 parts by weight and 0.0001 to 0.001 parts by weight of Yellow No. 4 (CI 19140).
6. The method of claim 5,
The 1,2-hexanediol (1,2-Hexanediol) 1.857 parts by weight, glycolic acid (Glycolic Acid) 1.05 parts by weight, purified water (Water) 0.6 parts by weight, hydroxypropyltrimonium hyaluronate (Hydroxypropyltrimonium Hyaluronate) ) 0.0001 parts by weight, Palmitoyl Tripeptide-1 0.00001 parts by weight, Hydroxyethylcellulose 0.2 parts by weight, Carbomer 0.001 parts by weight, Sodium Hyaluronate 0.001 parts by weight, Anigozanthos Flavidus Extract 0.002 parts by weight, Niacinamide 2 parts by weight, Scutellaria Baicalensis Root Extract 0.5 parts by weight, Paeonia Suffruticosa Root Extract 0.5 parts by weight , Butylene Glycol 0.32 parts by weight, Adenosine 0.04 parts by weight, Polysorbate 20 0.0005 parts by weight, Hydrolyzed Sodium Hyaluronate 0.000001 parts by weight , Potassium Hyaluronate 0.0000002 parts by weight, Sodium Acetylated Hyaluronate 0.00001 parts by weight, Hydrolyzed Hyaluronic Acid 0.00001 parts by weight, Palmi Palmitoyl Tetrapeptide-7 0.000005 parts by weight, Hyaluronic Acid 0.0000025 parts by weight, Sodium Hyaluronate Crosspolymer 0.0000 01 parts by weight, glycerin 0.83 parts by weight, Lavandula Angustifolia (Lavender) Water 90.87 parts by weight, Chitosan 1.23 parts by weight, Yellow No. 5 (CI 15985) 0.0005 parts by weight, and Yellow No. 4 (CI) 19140) Peel-up lifting ampoule, characterized in that it contains 0.0005 parts by weight.

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