KR102359688B1 - Vascular for practice and manufacturing method of the same - Google Patents

Abstract

Provided are a blood vessel for practice for forming a blood vessel most similar to an actual blood vessel of an object having different blood vessels and blood flow information, and a manufacturing method thereof. A method for manufacturing a blood vessel for practice includes extracting blood vessel data and blood flow data including blood vessel shape and blood flow analysis information of an object, generating a three-dimensional blood vessel model according to the blood vessel data and blood flow data, and based on the blood vessel model, The step of outputting a blood vessel core, the steps of forming a structure by applying different first outer layers, second outer layers, and third outer layers according to blood vessel data and blood flow data to the outer surface of the blood vessel core, and forming a blood vessel core inside the structure removing at least a portion of the inside of the structure from the interior space from which the blood vessel core has been removed to form an aneurysm inducing layer; and connecting pumps to both open ends of the structure to apply pressure to the interior space. .

Description

Vascular for practice and manufacturing method of the same

The present invention relates to a blood vessel for practice and a method for manufacturing the same, and to a blood vessel for practice for forming a blood vessel most similar to an actual blood vessel of an object having different blood vessels and blood flow information, and a method for manufacturing the same.

In general, the frequency of procedures for treating vascular diseases is increasing, and in order to secure the stability of the procedure, new medical equipment necessary for the procedure has been developed and used.

However, the medical staff using the developed medical equipment requires a high level of proficiency, but a large number of doctors have difficulty in accessing the vascular system, so the proficiency is not sufficient. there is a problem.

In addition, information on blood vessels such as shape and thickness of blood vessels is different for each individual patient, and aneurysms occur in different locations, so there is a problem in that there is a risk that there is a detailed difference in the procedure even for the same procedure.

Therefore, there was a need for a method of manufacturing a blood vessel most similar to the actual blood vessel of a patient so that a patient having different blood vessels and blood flow information can be operated with high skill and precision.

Republic of Korea Patent Registration No. 10-1949846 (“Method for manufacturing a structure for manufacturing artificial blood vessels using 3D printing, a structure for manufacturing an artificial blood vessel manufactured therefrom, a method for manufacturing an artificial blood vessel using a structure for manufacturing an artificial blood vessel, and manufacturing therefrom) artificial blood vessels”, Ulsan Institute of Science and Technology, 2019.02.13) Japanese Patent Publication No. 4303643 (“Artificial tissue and its manufacturing method”, Morita Ikuo, 2009.05.01) Republic of Korea Patent Registration No. 10-1855806 (“Artificial blood vessel and its manufacturing method”, Korea Institute of Machinery and Materials, 2018.05.02)

The technical problem to be achieved by the present invention is to solve this problem, and relates to a blood vessel for practice for forming a blood vessel most similar to an actual blood vessel of an individual having different blood vessels and blood flow information, and a method for manufacturing the same.

A method for manufacturing a blood vessel for practice according to an embodiment of the present invention includes extracting blood vessel data and blood flow data including blood vessel shape and blood flow analysis information of an object, and generating a three-dimensional blood vessel model according to the blood vessel data and the blood flow data. generating, outputting a blood vessel core based on the blood vessel model, and applying different first outer layers, second outer layers, and third outer layers according to the blood vessel data and the blood flow data to the outer surface of the blood vessel core forming a structure, removing the blood vessel core from the inside of the structure; removing at least a portion of the inside of the structure from the internal space from which the blood vessel core is removed to form an aneurysm inducing layer; Connecting a pump to the open both ends of the step of applying pressure to the inner space.

The forming of the aneurysm inducing layer may include removing a portion of at least one of the first outer layer, the second outer layer, and the third outer layer.

In the forming of the aneurysm inducing layer, a component having a strength different from that of the first outer layer, the second outer layer, and the third outer layer may be applied to a portion from which the inside of the structure is removed to form the aneurysm inducing layer.

In the forming of the aneurysm inducing layer, a position and a thickness of the aneurysm inducing layer may be calculated based on the blood vessel data and blood flow data.

The first outer layer, the second outer layer, and the third outer layer may have different thicknesses, components, and strengths extracted from the blood vessel data.

In the forming of the structure, the strength may be changed by irradiating heat or ultraviolet rays to each of the outer surfaces of the first outer layer, the second outer layer, and the third outer layer.

Forming the structure may include an auxiliary outer layer disposed between the plurality of outer layers.

The auxiliary outer layer may be formed of a thin film.

The auxiliary outer layer may be formed in a cylindrical shape to surround an outer circumferential surface of at least one of the outer layers.

The auxiliary outer layer may be disposed to face each other or to be shifted from each other based on the blood vessel data and the blood flow data based on the inner space.

The auxiliary outer layer may be spaced apart from each other in the longitudinal direction of the structure based on the blood vessel data and the blood flow data.

A blood vessel manufacturing method for practice according to another embodiment of the present invention comprises the steps of extracting blood vessel data and blood flow data including blood vessel shape and blood flow analysis information of an object, and generating a three-dimensional blood vessel model according to the blood vessel data and the blood flow data. generating, outputting a blood vessel core based on the blood vessel model; forming a coating layer by applying a first outer layer according to the blood vessel data and the blood flow data to an outer surface of the blood vessel core; 1 forming an aneurysm inducing layer on at least a portion of the outer surface of the outer layer, and repeatedly applying a coating layer to the outer surface of the first outer layer to form a structure comprising the first outer layer, the second outer layer, and the third outer layer and removing the blood vessel core inside the structure, and applying pressure to the internal space by connecting pumps to both open ends of the structure.

The forming of the aneurysm inducing layer may include removing at least a portion of the outer surface of the first outer layer, irradiating at least a portion with heat or ultraviolet light, or applying a component different from that of the first outer layer to form the aneurysm inducing layer. can

The forming of the structure may include repeatedly forming the aneurysm on an outer surface of at least one of the second outer layer and the third outer layer.

A first outer layer formed by being applied to the outer peripheral surface of a blood vessel core output in three dimensions according to blood flow data and blood vessel data including blood vessel shape and blood flow analysis information, and including an internal space formed by removing the blood vessel core; A second outer layer formed by applying a component different from the first outer layer according to the blood vessel data and the blood flow data on the outer peripheral surface of the first outer layer, and the first outer layer according to the blood vessel data and the blood flow data on the outer peripheral surface of the second outer layer and a third outer layer formed by coating a component different from that of the second outer layer, and an aneurysm-inducing layer formed by removing at least a portion of the first outer layer, the second outer layer, and the third outer layer from the inner space.

The blood vessel for practice and the method for manufacturing the same of the present invention, each of which manufactures blood vessels most similar to actual blood vessels of a patient subject having different blood vessels and blood flow information and the location of an aneurysm, thereby enabling precise surgical practice and improving the surgeon's proficiency can be improved

In particular, there is a feature that can increase the understanding and application of doctors by manufacturing a blood vessel having the shape and properties most similar to that of a patient's individual blood vessel, thereby enabling more efficient surgical practice.

1 is a cross-sectional view of a blood vessel for practice according to an embodiment of the present invention.
2 is a diagram illustrating a blood vessel model.
3 is a cross-sectional view of a blood vessel for practice showing a modified example of an auxiliary outer layer and an aneurysm inducing layer.
Figure 4 is a photograph showing the manufacturing sequence of the blood vessel for practice according to an embodiment of the present invention.
5 is a diagram illustrating a method for manufacturing a blood vessel for practice according to an embodiment of the present invention.
6 is a flowchart of a method for manufacturing a blood vessel for practice according to an embodiment.
7 and 8 are diagrams of blood vessels for practice according to another embodiment of the present invention.
9 is a diagram illustrating a method for manufacturing a blood vessel for practice according to another embodiment.
10 is a flowchart of a method for manufacturing a blood vessel for practice according to another embodiment.

Advantages and features of the present invention and methods for achieving them will become apparent with reference to the embodiments described below in detail in conjunction with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but may be implemented in various different forms, and only these embodiments allow the disclosure of the present invention to be complete and those of ordinary skill in the art to which the present invention pertains. It is provided to fully inform the person of the scope of the invention, and the present invention is only defined by the claims. Like reference numerals refer to like elements throughout.

Hereinafter, a blood vessel for practice and a method for manufacturing a blood vessel for practice according to an embodiment of the present invention will be described in detail with reference to FIGS. 1 to 6 .

After explaining the blood vessel for practice of the present invention with reference to FIGS. 1 to 3 , a method for manufacturing the blood vessel for practice of the present invention will be described in detail with reference to FIGS. 4 to 6 .

A blood vessel for practice of the present invention will be described with reference to FIGS. 1 to 3 .

1 is a cross-sectional view of a blood vessel for practice according to the present invention, FIG. 2 is a diagram illustrating a blood vessel model, and FIG. 3 is a cross-sectional view of a blood vessel for practice showing a modified example of an auxiliary outer layer and an aneurysm inducing layer.

The blood vessel 100 for practice of the present invention is a structure formed to increase the proficiency of medical staff who are difficult to access the treatment of vascular diseases related to an aneurysm and to secure the stability of the procedure. Based on the blood vessel shape and blood flow information of the subject where the aneurysm occurred formed to resemble reality. The blood vessels 100 for practice are formed most similar to the actual blood vessels of each object having different blood vessels and blood flow information, and provide the medical staff with a structure for reproducing the procedure before the procedure, thereby increasing the precision and proficiency of the procedure. . Hereinafter, the blood vessel 100 for practice of the present invention will be described in detail.

The blood vessel 100 for practice includes a first outer layer 21 , a second outer layer 22 , a third outer layer 23 , and an aneurysm inducing layer 25 to form a structure similar to an actual blood vessel. Specifically, it is formed by being applied to the outer peripheral surface of the blood vessel core 10 output in three dimensions according to blood vessel data and blood flow data including blood vessel shape and blood flow analysis information, and includes an internal space 11 formed by removing the blood vessel core. A first outer layer 21 and a second outer layer 22 formed by coating an outer peripheral surface of the first outer layer 21 with a component different from the first outer layer 21 according to blood vessel data and blood flow data, and a second outer layer ( 22) on the outer peripheral surface of the first outer layer 21 and second outer layer 22 according to the blood vessel data and blood flow data, and a second outer layer 22 formed by applying a different component, and from the inner space 11 to the first outer layer ( 21), an aneurysm inducing layer 25 formed by removing at least a portion of the second outer layer 22 and the third outer layer 23 to be indented.

Prior to the description of each configuration of the blood vessel 100 for practice, the blood vessel data refers to the three-dimensional blood vessel shape of the object extracted by angiography, and physical property information such as the thickness of the blood vessel of the object, the components constituting the blood vessel, and the density, and the like, and blood flow. The data refers to common data of each object and ancillary tissues surrounding or surrounding blood vessels. The three-dimensional blood vessel model refers to a shape of a blood vessel of an object formed in three dimensions according to blood vessel data and blood flow data, and the blood vessel core 10 outputs a three-dimensional blood vessel model extracted from the blood vessel data and blood flow data using a 3D printer. It means a three-dimensional three-dimensional structure. The blood vessel data and blood flow data will be described later in detail through a method of manufacturing blood vessels for practice.

The first outer layer 21 is a coating layer applied to the outer surface of the blood vessel core 10 output based on the three-dimensional blood vessel model of the object, and is made of a material according to analysis of blood vessel data and blood flow data. The first outer layer 21 may calculate thickness and components according to blood vessel data and blood flow data, for example, hyaluronic acid, gelatin, glycerol, alginate, gelatin. And at least one of fibroblasts, endothelial cells, Human Umbilical Vein Endothelial Cells (HUVEC), and fibrinogen by a mixture of alginate is prepared by mixing the vascular core (10) It can be applied to the outer surface. The first outer layer 21 is applied to the outer circumferential surface of the blood vessel core 10 and is formed into a cylindrical shape inside which the blood vessel core 10 is separated from the inner circumferential surface and forms an empty space therein after being cured. The first outer layer 21 may be formed in a tortuous shape as shown in FIG. 2 according to a three-dimensional blood vessel model of the object. The drawing shown in FIG. 1 is an enlarged view of a cut part of the blood vessel 100 for practice, and the blood vessel 100 for practice of the present invention is not limited to the shape shown in FIG. 1 but is shown in FIG. It may be formed in a serpentine shape, such as a curved shape. A second outer layer 22 , a third outer layer 23 , and an auxiliary outer layer 24 may be coated on the outer surface of the first outer layer 21 .

The second outer layer 22 and the third outer layer 23 are structures forming a part of the blood vessel 100 for practice. The second outer layer 22 is applied to the outer surface of the first outer layer 21 , and the third outer layer 23 forms a coating layer applied to the outer surface of the second outer layer 22 . The second outer layer 22 and the third outer layer 23, like the first outer layer 21, are made of thickness and components according to the interpretation of blood vessel data and blood flow data, for example, hyaluronic acid, gelatin, glycerol, alginate. , It consists of a component mixed with at least one of fibroblasts, endothelial cells, human umbilical vein endothelial cells, and fibrinogen by a mixture of gelatin and alginate. The second outer layer 22 and the third outer layer 23 may be coated and formed in close contact with the surfaces of the first outer layer 21 and the second outer layer 22 to form a thin film.

The first outer layer 21 , the second outer layer 22 , and the third outer layer 23 form a structure 20 having different thicknesses and components based on blood vessel data and blood flow data, and are disposed between at least one layer. An auxiliary outer layer 24 may be formed.

At least one auxiliary outer layer 24 is formed between the first outer layer 21, the second outer layer 22, and the third outer layer 23 to adjust the strength of the blood vessel 100 for practice. accomplish The auxiliary outer layer 24 is formed of a separate material having different strength from the first outer layer 21 , the second outer layer 22 , and the third outer layer 23 . The auxiliary outer layer 24 may be closely disposed to surround the outer circumferential surface of the first outer layer 21 or the second outer layer 22, and is in close contact to surround the outer circumferential surface of the first outer layer 21 as shown in the drawing. Let me explain with an example.

Referring to FIG. 3 in more detail, the auxiliary outer layer 24 may have various thicknesses and shapes. The auxiliary outer layer 24 may be formed on the outer peripheral surface of the first outer layer 21 to express differently the degree of deformation of the blood vessel when a force is applied to the blood vessel in the transverse or longitudinal direction. The auxiliary outer layer 24 may have different shapes to be formed in close contact with the outer peripheral surface of the first outer layer 21 to adjust the strength of blood vessels differently. The auxiliary outer layer 24 may be formed in a shape such as a thin and slender cylindrical shim, or may be formed as a thin film. The auxiliary outer layer 24 is formed in an elongated cylindrical shape as in FIG. 1 and is disposed to surround the upper peripheral surface of the first outer layer 21 in the longitudinal direction of the structure 20 as an example. However, the auxiliary outer layer 24 is formed in the form of a thin film forming a coating layer applied to the outer peripheral surface of the first outer layer 21 as shown in FIG. 3A , and is disposed between the first outer layer 21 and the second outer layer 22 . can be In addition, the auxiliary outer layer 24 is arranged to surround the outer circumferential surface of the first outer layer 21 in an oblique line along the longitudinal direction of the structure 20, as in FIGS. 3B to 3D, with the inner space 11 as the center A plurality of the disposed up and down may be arranged to face each other to form a symmetry or to be displaced from each other, and may be arranged by adjusting the spacing to be narrow or wide in the longitudinal direction of the structure 20 . The auxiliary outer layer 24 can be formed in various shapes as shown in FIG. 2 to adjust the strength of each location of the blood vessel 10 for practice differently, and the degree of deformation of the blood vessel is expressed differently to determine the directionality of the blood vessel of the object. Features can be formed to resemble reality. In addition, the auxiliary outer layer 24 may be formed of a material having a different thickness or different strength depending on the position of the circumferential surface of the cross-section perpendicular to the longitudinal direction, and may be formed by mixing a film and a cylindrical shape.

In the structure 20 including the first outer layer 21 , the second outer layer 22 , and the third outer layer 23 , the aneurysm inducing layer 25 cut from the inner space 11 is formed.

The aneurysm inducing layer 25 is an empty space indented from the inner circumferential surface of the structure 20 , and may be formed by cutting at least a portion of the structure 20 . The aneurysm inducing layer 25 is formed by cutting at least one of the first outer layer 21 , the second outer layer 22 , the third outer layer 23 and the auxiliary outer layer 24 at a location where the aneurysm actually occurs in the blood vessel of the subject. As shown in the drawings, the first outer layer 21 and the auxiliary outer layer 24 may be cut and formed. The aneurysm inducing layer 25 is formed at a location where an aneurysm occurs in an actual blood vessel of an object calculated from blood vessel data and blood flow data. In addition, as shown in FIG. 3E , the aneurysm inducing layer 25 may be formed at different positions for each subject by calculating a position formed on the inner peripheral surface of the structure 20 based on blood vessel data and blood flow data. The aneurysm inducing layer 25 may inflate and inflate as the fluid 27 flows into the internal space 11 as pumps 26 are connected to both ends of the blood vessel 100 for practice. Accordingly, the aneurysm inducing layer 25 forms an aneurysm similar to the actual blood vessel of the subject in the blood vessel 100 for practice, increases the application power of the medical staff to establish a highly stable treatment plan, and provides the most similar to the actual blood vessel 100 for each of the objects. ) can be formed.

On the other hand, the aneurysm inducing layer 25 of the blood vessel 100 for practice according to an embodiment includes at least a portion of the first outer layer 21 , the second outer layer 22 , and the third outer layer 23 in the inner space 11 . What is formed by removing it will be described as an example. However, the present invention is not limited thereto, and the aneurysm inducing layer 25 may be formed by irradiating a portion of the structure 20 with heat or ultraviolet rays, or by applying a portion having a different strength to a portion of the structure 20 . In relation to the blood vessel 100a for practice according to another embodiment, it will be described later in detail with reference to FIGS. 7 and 8 .

Hereinafter, a method of manufacturing a blood vessel for practice according to an embodiment of the present invention will be described in detail with reference to FIGS. 4 to 6 .

4 is a photograph showing the manufacturing procedure of blood vessels for practice, FIG. 5 is a diagram illustrating a manufacturing method of blood vessels for practice, and FIG. 6 is a flowchart of the method of manufacturing blood vessels for practice.

A method of manufacturing a blood vessel for practice will be briefly described with reference to the step-by-step photos of manufacturing the blood vessel for practice in FIG. 4 , and will be described later in detail with reference to FIGS. 5 and 6 .

The method of manufacturing a blood vessel for practice according to an embodiment of the present invention comprises the steps of extracting blood vessel data and blood flow data including blood vessel shape and blood flow analysis information of an object (S110), and a three-dimensional blood vessel model according to the blood vessel data and blood flow data. Forming (S120), outputting the blood vessel core 10 based on the blood vessel model (S130), on the outer surface of the blood vessel core 10 different first outer layers 21 according to blood vessel data and blood flow data , forming the structure 20 by applying the second outer layer 22 and the third outer layer 23 (S140), and removing the blood vessel core 10 inside the structure 20 (S150); Forming an aneurysm inducing layer 25 by removing at least a portion of the inside of the structure 20 from the internal space 11 from which the blood vessel core 10 has been removed (S160, see FIG. 5G), and opening the structure 20 It includes a step (S170) of applying pressure to the internal space 11 by connecting the pump 26 to both ends.

The blood vessel manufacturing method for practice extracts blood vessel data and blood flow data including blood vessel shape and blood flow analysis information of an object, and predicts a change in thickness and physical properties of a blood vessel. A 3D blood vessel model is generated based on the blood vessel data and blood flow data, and the blood vessel core 10 is output using a 3D printer based on the blood vessel model stored in the 3D 3D file. The structure 20 is formed by applying a coating layer to the outer surface of the blood vessel core 10 output by the 3D printer and curing it, and then removing the inner blood vessel core. Thereafter, the pump 26 may be connected to the structure 20 and the fluid 27 may be supplied to form a blood vessel 100 for practice similar to an actual blood vessel model.

Referring to FIGS. 5 and 6 , the blood vessel manufacturing method for practice is described in more detail. In the step of extracting blood vessel data and blood flow data ( S110 ), the blood vessel shape and blood flow analysis information of the object are calculated. The blood vessel data includes a three-dimensional blood vessel shape of an object extracted by angiography, and physical property information such as a thickness of a blood vessel of the object, components constituting the blood vessel, density, and strength. The blood flow data may include not only blood flow information data of each object, but also ancillary tissues surrounding or surrounding blood vessels, for example, incidental tissues inside the skull when the skull is opened, environmental factors, and the like.

After the blood vessel data and blood flow data are extracted, a three-dimensional blood vessel model is generated according to the blood vessel data and blood flow data (S120). The 3D blood vessel model refers to a shape of a blood vessel of an object formed in three dimensions according to blood vessel data and blood flow data, and may include, for example, 3D modeling of a shape of a blood vessel of an object generated by angiography.

After the 3D blood vessel model most similar to the actual blood vessel of the object is generated, the blood vessel core 10 based on the blood vessel model is output ( S130 ). 5A shows a cross-sectional view of a portion of the blood vessel core 10, and outputs the blood vessel core 10 based on the blood vessel model. The blood vessel core 10 in FIG. 5A is a view showing a part of the whole output based on the overall blood vessel model in FIG. 2 described above, and the blood vessel core 10 of the blood vessel 100 for practice formed based on actual blood vessels. may be formed in a serpentine shape.

After outputting the blood vessel core 10, different first outer layers 21, second outer layers 22, and third outer layers 23 are applied to the outer surface of the blood vessel core 10 according to blood vessel data and blood flow data. The structure 20 is formed (S140). Referring to FIGS. 5B to 5E , the first outer layer 21 , the second outer layer 22 and the third outer layer 23 are coated on the outer circumferential surface of the blood vessel core 10 to form the structure 20 . The drawings are shown step by step. At least one of fibroblasts, endothelial cells, human umbilical vein endothelial cells, and fibrinogen by a mixture of hyaluronic acid, gelatin, glycerol, alginate, gelatin and alginate according to blood vessel data and blood flow data is mixed on the outer surface of the blood vessel core 10 The prepared component is applied to form the first outer layer 21 . On the outer surface of the first outer layer 21, an auxiliary outer layer 24 having an elongated shim shape is closely disposed to surround the first outer layer 21 in the longitudinal direction, and the cured first outer layer 21 and the auxiliary outer layer A second outer layer (22) is applied to the outer surface of (24). Subsequently, the third outer layer 23 is applied to the outer surface of the second outer layer 22 . The first outer layer 21, the auxiliary outer layer 24, the second outer layer 22, and the third outer layer 23 constituting the structure 20 are hyaluronic acid, gelatin, glycerol, alginate, It may consist of different components and thicknesses prepared by mixing at least one of fibroblasts, endothelial cells, human umbilical vein endothelial cells, fibrinogen, and the like by a mixture of gelatin and alginate.

After the first outer layer 21 , the auxiliary outer layer 24 , the second outer layer 22 , and the third outer layer 23 applied to the outer peripheral surface of the blood vessel core 10 are all cured to form the structure 20 , the structure (20) The internal blood vessel core 10 is removed (S150). 5f shows a view of the structure 20 from which the vascular core 10 is removed, and the vascular core 10 disposed inside the first outer layer 21 is removed and the structure 20 as shown in the figure. An inner space 11 is formed therein. In the structure 20, an empty space from which the blood vessel core 10 is removed is formed therein, and the first outer layer 21, the auxiliary outer layer 24, the second outer layer 22, and the third outer layer 23 are sequentially stacked. It is formed in the formed cylindrical shape.

In the structure 20 thus formed, at least a portion of the inside of the structure 20 is removed from the internal space 11 to form the aneurysm inducing layer 25 ( S160 ). FIG. 5G shows a view in which the aneurysm inducing layer 25, which is a space recessed from the inner circumferential surface of the structure 20, is formed by cutting a portion of the inside of the structure 20. As shown in FIG. The aneurysm inducing layer 25 may be formed according to the thickness and position calculated according to the blood vessel data and blood flow data as well as the first outer layer 21 and the auxiliary outer layer 24 . For example, the aneurysm inducing layer 25 is formed at a location where an aneurysm occurs in an actual blood vessel of an object calculated from blood vessel data and blood flow data. In addition, the aneurysm inducing layer 25 may be formed at different positions for each object by calculating a position formed on the inner circumferential surface of the structure 20 based on blood vessel data and blood flow data.

In the structure 20 on which the aneurysm inducing layer 25 is formed, pumps 26 are connected to both open ends, and pressure is applied to the internal space 11 ( S170 ). 5H and 5I, when the pump 26 is connected to both open ends of the blood vessel 100 for practice to supply the fluid 27 to the internal space 11, the blood vessel for practice similar to the actual blood vessel of the object (100) can be formed. When the fluid 27 is continuously supplied to the internal space 11 of the structure 20 , as shown in FIG. 5J , the aneurysm inducing layer 25 swells to realize a blood vessel in which an actual aneurysm occurs. In this way, the blood vessel 100 for practice manufactured by the method for manufacturing a blood vessel for practice of the present invention is formed, and the aneurysm inducing layer 25 of the blood vessel 100 for practice forms an aneurysm similar to the actual blood vessel of the subject, thereby enabling the medical staff to apply the procedure. It is possible to establish a treatment plan with high stability by increasing the In addition, the blood vessel 100 for practice of the present invention is formed based on blood vessel data and blood flow data to form an aneurysm in the same position as an actual blood vessel, and can implement the same thickness and feel as a real blood vessel, so that medical staff can practice more precise procedures makes it possible

Hereinafter, a blood vessel for practice and a method for manufacturing a blood vessel for practice according to another embodiment of the present invention will be described in detail with reference to FIGS. 7 to 10 .

7 and 8 are diagrams of a blood vessel for practice according to another embodiment of the present invention, FIG. 9 is a diagram illustrating a method for manufacturing a blood vessel for practice according to another embodiment, and FIG. 10 is a diagram of a blood vessel for practice according to another embodiment It is a flowchart of the method.

The blood vessel 100a for practice according to another embodiment of the present invention is substantially the same as the embodiment described above except for the aneurysm inducing layer 25a. Accordingly, the same reference numerals are assigned to the same components as those already described, and detailed descriptions thereof will be omitted.

The blood vessel 100a for practice according to another embodiment of the present invention irradiates heat or ultraviolet rays to the outer surface of at least one of the first outer layer 21, the second outer layer 22, and the third outer layer 23, or the intensity is mutually high. and an aneurysm inducing layer 25a formed by applying other components.

In one embodiment, the aneurysm-inducing layer 25 may be formed by changing the thickness of the structure 20 by removing the inner coating layer, but in another embodiment, the aneurysm-inducing layer 25a has properties of the structure 20 It can also be changed and formed. Unlike the embodiment in which the aneurysm inducing layer 25a is formed by removing at least a portion of the inside of the structure 20 , at least one of the first outer layer 21 , the second outer layer 22 , and the third outer layer 23 . It is formed by irradiating heat or ultraviolet rays on the outer surface of the

Referring to FIG. 7 , the aneurysm inducing layer 25a is formed by irradiating heat or ultraviolet light to a specific location on the outer surface of at least one of the first outer layer 21 , the second outer layer 22 , and the third outer layer 23 . can be The aneurysm inducing layer 25a is formed by irradiating heat or ultraviolet rays to a specific position on the outer surface of the first outer layer 21 , so that the intensity may be changed differently from the rest of the positions to which heat or ultraviolet rays are not irradiated. The second outer layer 22 may be applied to the entire outer surface of the first outer layer 21 irradiated with heat or ultraviolet light at a specific location, and the second outer layer 22 is in contact with the aneurysm inducing layer 25a formed on the first outer layer 21 . Heat or ultraviolet rays may be irradiated to the position of the outer layer 22 . In the same way, heat or ultraviolet light may be irradiated to the third outer layer 23 facing the aneurysm inducing layer 25a formed in the first outer layer 21 and the second outer layer 22 to form the aneurysm inducing layer 25a. have. The aneurysm inducing layer 25a thus formed has a different strength from the rest of the portion where the aneurysm inducing layer 25a is not formed. In the present specification, the aneurysm inducing layer 25a is formed by irradiating heat or ultraviolet light to each outer layer of the structure 20 as an example, but the present disclosure is not limited thereto, and the first outer layer 21 and the second outer layer 22 are not limited thereto. ), a structure formed by irradiating heat or ultraviolet rays to the outer surface of at least one of the third outer layer 23, or coating the first outer layer 21, the second outer layer 22, and the third outer layer 23. The aneurysm inducing layer 25a may be formed by irradiating heat or ultraviolet light to the outer surface of the . On the other hand, in the present invention, the strength of a portion of the aneurysm inducing layer 25a is adjusted by changing the physical properties of the structure 20, but heat or ultraviolet light is not limited thereto.

Referring to FIG. 8 , the aneurysm inducing layer 25b may be formed by applying components having different strengths to the outer surface of at least one of the first outer layer 21 , the second outer layer 22 and the third outer layer 23 . may be The aneurysm inducing layer 25b is formed when the first outer layer 21, the second outer layer 22, and the third outer layer 23 are sequentially applied to the outer surface of the blood vessel core 10, the first outer layer 21, The second outer layer 22 and the third outer layer 23 may be formed by coating components having different strengths on a portion of the outer surface. For example, an aneurysm inducing layer 25b is formed by applying a component weaker in strength than the first outer layer 21 to the outer surface of the first outer layer 21, and the second outer surface of the aneurysm inducing layer 25b is coated with a second component. The structure 20 may be formed by applying the outer layer 22 and the third outer layer 23 . At this time, a step is formed as the aneurysm inducing layer 25b is applied to the outer surface of the first outer layer 21, but when the second outer layer 22 is coated on the outer surface of the aneurysm inducing layer 25b, the aneurysm inducing layer It may be applied such that the thickness of the specific location where the 25b is formed is thin, or only the specific location where the aneurysm inducing layer 25b is formed may not be applied. In other words, the second outer layer 22 may be coplanar with the aneurysm inducing layer 25b to form a coating layer in which the aneurysm inducing layer 25b does not protrude. A specific position of the structure 20 in which the aneurysm inducing layer 25b is formed is composed of a component having less strength than the first outer layer 21 , the second outer layer 22 , and the third outer layer 23 , and is formed in the structure 20 . arranged to be surrounded. Accordingly, the aneurysm inducing layer 25b may be easily deformed while inflated by the pressure applied to the internal space 11 of the structure 20 . The aneurysm inducing layer 25b is not limited to the illustrated drawings, and may be applied to occupy a portion of the third outer layer 23 as well as the second outer layer 22 . On the other hand, the aneurysm inducing layer 25b may be formed opposite to the illustrated drawing, or the aneurysm inducing layer 25b may be applied to the remaining portions except for the position where the aneurysm inducing layer 25b is formed in FIG. 9 . For example, the aneurysm inducing layer 25b may be formed at a predetermined location where a component with high strength is applied to the outer surface of the first outer layer 21 except at a predetermined location, and is not applied. It may be formed in various ways. The blood vessel 100b for practice may be formed by applying the second outer layer 22 and the third outer layer 23 to the outer surface of the aneurysm inducing layer 25b and removing the blood vessel core 10 from the inside of the structure 20. .

Hereinafter, a method of manufacturing a blood vessel for practice according to another embodiment of the present invention will be described in detail with reference to FIGS. 9 and 10 .

9 is a diagram illustrating a method of manufacturing a blood vessel for practice, and FIG. 10 is a flowchart illustrating a method of manufacturing a blood vessel for practice.

The blood vessel manufacturing method for practice includes extracting blood vessel data and blood flow data including blood vessel shape and blood flow analysis information of an object (S210), and generating a three-dimensional blood vessel model according to the blood vessel data and blood flow data (S220); The step of outputting the blood vessel core 10 based on the blood vessel model (S230), and the step of forming a coating layer by applying the first outer layer 21 according to the blood vessel data and blood flow data on the outer surface of the blood vessel core 10 ( S240), forming an aneurysm inducing layer 25a on at least a portion of the outer surface of the first outer layer 21 (S250), and repeatedly applying a coating layer to the outer surface of the first outer layer 21 to obtain the first Forming the structure 20 including the outer layer 21, the second outer layer 22, and the third outer layer 23 (S260), and removing the blood vessel core 10 inside the structure 20 ( S270) and connecting the pumps 26 to both ends of the structure 20 to apply pressure to the internal space 11 (S280).

A method for manufacturing a blood vessel for practice according to another embodiment of the present invention includes the steps of forming a coating layer (S240), forming an aneurysm inducing layer (25a) (S250), and a structure (S250) as shown in the drawings of FIGS. 20), except for the step 260 of forming the blood vessel core 10 and the step S270 of removing the blood vessel core 10, it is substantially the same as the method for manufacturing a blood vessel for practice of an embodiment already described. Accordingly, the previously described manufacturing steps of extracting blood vessel data and blood flow data (S210), generating a three-dimensional blood vessel model (S220), outputting the blood vessel core 10 (S230), internal space ( Step 11) of applying the pressure (S280) and the detailed description of FIGS. 9A, 9H, and 9I including the step S280 will be omitted.

In the blood vessel manufacturing method for practice according to another embodiment of the present invention, the first outer layer 21 is applied to the outer peripheral surface of the blood vessel core 10 output in three dimensions according to blood vessel data and blood flow data including blood vessel shape and blood flow analysis information. to form a coating layer (S240). Referring to FIG. 9B , the first outer layer 21 is formed on the outer surface of the blood vessel core 10 using components according to blood vessel data and blood flow data ( S240 ). After the first outer layer 21 is applied and the applied first outer layer 21 is cured, an aneurysm inducing layer 25a is formed on at least a portion of the outer surface of the first outer layer 21 ( S250 ). When the aneurysm inducing layer 25a is formed on the outer surface of the first outer layer 21, the aneurysm inducing layer is formed by irradiating at least a portion of the outer surface of the first outer layer 21 with heat or ultraviolet rays or applying components having different intensities. (25a) can be formed. For example, as shown in FIG. 9C , heat or ultraviolet light is irradiated to a specific location of the first outer layer 21 where the aneurysm inducing layer 25a is to be formed to change the intensity of a portion of the first outer layer 21 to make a first 1 An aneurysm inducing layer 25a may be formed on a portion of the outer layer 21 . Also, as in FIG. 8 described above, an aneurysm inducing layer 25a is formed by applying a component different from that of the first outer layer 21 to a specific location of the first outer layer 21 where the aneurysm inducing layer 25a is to be formed. can do. Referring to FIG. 9D , an auxiliary outer layer 24 may be formed on the outer surface of the first outer layer 21 on which the aneurysm inducing layer 25a is formed, as in one embodiment, and the auxiliary outer layer 24 is in one embodiment. Since it includes the same configuration as and is formed on the surface of the first outer layer 21 in the same way, a detailed description thereof will be omitted. Subsequently, referring to FIGS. 9E and 9F , the coating layer of the second outer layer 22 and the third outer layer 23 is formed on the outer surface of the first outer layer 21 on which the aneurysm inducing layer 25a and the auxiliary outer layer 24 are formed. is repeatedly applied to form a structure 20 including the first outer layer 21 , the second outer layer 22 , and the third outer layer 23 ( S260 ). At this time, in the step of forming the structure 20 ( S260 ), the second outer layer 22 and the third outer layer 23 may be continuously applied, but in addition to the drawings shown, after the second outer layer 22 is cured The aneurysm inducing layer 25a may also be formed in the second outer layer 22 by irradiating the outer surface of the second outer layer 22 with heat or ultraviolet light, and the third outer layer 23 is formed with the aneurysm inducing layer 25a. It may be formed by being applied to the outer surface of the second outer layer 22 . In this way, in the step of forming the structure 20 ( S260 ), the step of forming the aneurysm inducing layer 25a on the outer surface of at least one of the second outer layer 22 and the third outer layer 23 ( S250 ) is repeated. can be done with However, the present invention is not limited thereto, and the aneurysm inducing layer 25a is formed on at least a portion of the first outer layer 21 , the second outer layer 22 , and the third outer layer 23 through a method other than heat or ultraviolet irradiation. can also be formed.

After the step of forming the coating layer (S240), the step of forming the aneurysm inducing layer (25a) (S250), and the step of forming the structure (S260) (S260), the structure 20 is formed inside as shown in FIG. 8G . The formed blood vessel core 10 may be removed (S270). In the method of removing blood vessels for practice in another embodiment of the present invention, after the structure 20 including the aneurysm inducing layer 25a, the first outer layer 21, the second outer layer 22, and the third outer layer 23 is formed, the blood vessel core ( 10) is removed to form the inner space 11 as an example, but removing the blood vessel core 10 (S270) is performed after the first outer layer 21 is applied to form a coating layer (S240) may be applied.

The blood vessel 100 for practice of the present invention can form the aneurysm inducing layer 25 by removing a portion of the plurality of outer layers and changing the thickness of the coating layer as in one embodiment, but the blood vessel 100a for practice is a different embodiment The proficiency of medical staff can be improved by implementing the aneurysm inducing layer 25a generated at a specific location as in an actual blood vessel, such as forming the aneurysm inducing layer 25a by changing the components and strength of the outer layer as in Fig.

Although embodiments of the present invention have been described above with reference to the accompanying drawings, those of ordinary skill in the art to which the present invention pertains will realize that the present invention can be implemented in other specific forms without changing the technical spirit or essential features. You will understand. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not restrictive.

10: vascular core
11: interior space
20: structure
21: first outer layer
22: outer layer
23: third outer layer
24: secondary outer layer
25, 25a, 25b: aneurysm inducing layer
26: pump
27: fluid
100, 100a, 100b: blood vessels for practice

Claims (17)

extracting blood vessel data and blood flow data including blood vessel shape and blood flow analysis information of the object;
generating a three-dimensional blood vessel model according to the blood vessel data and the blood flow data;
outputting a blood vessel core based on the blood vessel model;
forming a structure by applying different first outer layers, second outer layers, and third outer layers according to the blood vessel data and the blood flow data to the outer surface of the blood vessel core;
removing the blood vessel core inside the structure;
forming an aneurysm inducing layer by removing at least a portion of the inside of the structure from the internal space from which the blood vessel core is removed; and
applying pressure to the internal space by connecting a pump to both open ends of the structure;
includes,
The forming of the structure includes an auxiliary outer layer formed in a cylindrical shape and disposed between a plurality of outer layers to surround the outer peripheral surface of at least one outer layer,
The auxiliary outer layer is a blood vessel manufacturing method for practice, characterized in that based on the blood vessel data and the blood flow data, arranged to face each other or to be shifted from each other around the inner space. extracting blood vessel data and blood flow data including blood vessel shape and blood flow analysis information of the object;
generating a three-dimensional blood vessel model according to the blood vessel data and the blood flow data;
outputting a blood vessel core based on the blood vessel model;
forming a structure by applying different first outer layers, second outer layers, and third outer layers according to the blood vessel data and the blood flow data to the outer surface of the blood vessel core;
removing the blood vessel core inside the structure;
forming an aneurysm inducing layer by removing at least a portion of the inside of the structure from the internal space from which the blood vessel core is removed; and
applying pressure to the internal space by connecting a pump to both open ends of the structure;
includes,
The forming of the structure includes an auxiliary outer layer formed in a cylindrical shape and disposed between a plurality of outer layers to surround the outer peripheral surface of at least one outer layer,
The auxiliary outer layer is spaced apart along the longitudinal direction of the structure on the basis of the blood vessel data and the blood flow data is adjustable for practice blood vessel manufacturing method. 3. The method of claim 1 or 2,
Forming the aneurysm inducing layer comprises:
A method of manufacturing a blood vessel for practice of removing a portion of at least one of the first outer layer, the second outer layer, and the third outer layer. 3. The method of claim 1 or 2,
Forming the aneurysm inducing layer comprises:
A method of manufacturing an aneurysm inducing layer by applying a component having a strength different from that of the first outer layer, the second outer layer, and the third outer layer to a portion from which the inside of the structure is removed. 3. The method of claim 1 or 2,
Forming the aneurysm inducing layer comprises:
A method of manufacturing a blood vessel for practice, wherein the position and thickness of the aneurysm inducing layer are calculated based on the blood vessel data and the blood flow data. 3. The method of claim 1 or 2,
The first outer layer, the second outer layer, and the third outer layer have different thicknesses, components, and strengths extracted from the blood vessel data. 3. The method of claim 1 or 2,
Forming the structure comprises:
A method for manufacturing a blood vessel for practice in which the intensity is changed by irradiating heat or ultraviolet light to each of the outer surfaces of the first outer layer, the second outer layer, and the third outer layer. 3. The method of claim 1 or 2,
The auxiliary outer layer is a blood vessel manufacturing method for practice, characterized in that formed of a thin film. delete delete delete extracting blood vessel data and blood flow data including blood vessel shape and blood flow analysis information of the object;
generating a three-dimensional blood vessel model according to the blood vessel data and the blood flow data;
outputting a blood vessel core based on the blood vessel model;
forming a coating layer by applying a first outer layer according to the blood vessel data and the blood flow data to the outer surface of the blood vessel core;
forming an aneurysm inducing layer on at least a portion of an outer surface of the first outer layer;
forming a structure including the first outer layer, the second outer layer, and the third outer layer by repeatedly applying a coating layer to the outer surface of the first outer layer;
removing the blood vessel core inside the structure; and
applying pressure to the internal space by connecting a pump to both open ends of the structure;
includes,
The forming of the structure includes an auxiliary outer layer formed in a cylindrical shape and disposed between a plurality of outer layers to surround the outer peripheral surface of at least one outer layer,
The auxiliary outer layer is disposed to face each other or to shift away from each other based on the blood vessel data and the blood flow data in the inner space. extracting blood vessel data and blood flow data including blood vessel shape and blood flow analysis information of the object;
generating a three-dimensional blood vessel model according to the blood vessel data and the blood flow data;
outputting a blood vessel core based on the blood vessel model;
forming a coating layer by applying a first outer layer according to the blood vessel data and the blood flow data to the outer surface of the blood vessel core;
forming an aneurysm inducing layer on at least a portion of an outer surface of the first outer layer;
forming a structure including the first outer layer, the second outer layer, and the third outer layer by repeatedly applying a coating layer to the outer surface of the first outer layer;
removing the blood vessel core inside the structure; and
applying pressure to the internal space by connecting a pump to both open ends of the structure;
includes,
The forming of the structure includes an auxiliary outer layer formed in a cylindrical shape and disposed between a plurality of outer layers to surround the outer peripheral surface of at least one outer layer,
The auxiliary outer layer is spaced apart along the longitudinal direction of the structure on the basis of the blood vessel data and the blood flow data is an adjustable blood vessel manufacturing method for practice. 14. The method of claim 12 or 13,
Forming the aneurysm inducing layer comprises:
A method of manufacturing an aneurysm inducing layer by removing at least a portion of the outer surface of the first outer layer, irradiating at least a portion with heat or ultraviolet light, or applying a component different from that of the first outer layer. 14. The method of claim 12 or 13,
The forming of the structure may include repeatedly forming the aneurysm on an outer surface of at least one of the second outer layer and the third outer layer. a first outer layer formed by being applied to an outer circumferential surface of a blood vessel core output in three dimensions according to blood flow data and blood vessel data including blood vessel shape and blood flow analysis information, and including an internal space formed by removing the blood vessel core;
a second outer layer formed by coating an outer peripheral surface of the first outer layer with a component different from the first outer layer according to the blood vessel data and the blood flow data;
a third outer layer formed by coating an outer peripheral surface of the second outer layer with a component different from the first and second outer layers according to the blood vessel data and the blood flow data;
an aneurysm inducing layer formed by removing at least a portion of the first outer layer, the second outer layer, and the third outer layer from the inner space; and
It is formed in a cylindrical shape and comprises an auxiliary outer layer disposed between the plurality of outer layers so as to surround the outer circumferential surface of the at least one outer layer,
The auxiliary outer layer is disposed to face each other or to shift from each other based on the blood vessel data and the blood flow data based on the inner space. a first outer layer formed by being applied to an outer circumferential surface of a blood vessel core output in three dimensions according to blood flow data and blood vessel data including blood vessel shape and blood flow analysis information, and including an internal space formed by removing the blood vessel core;
a second outer layer formed by coating an outer peripheral surface of the first outer layer with a component different from the first outer layer according to the blood vessel data and the blood flow data;
a third outer layer formed by coating an outer peripheral surface of the second outer layer with a component different from the first and second outer layers according to the blood vessel data and the blood flow data;
an aneurysm inducing layer formed by removing at least a portion of the first outer layer, the second outer layer, and the third outer layer from the inner space; and
It is formed in a cylindrical shape and comprises an auxiliary outer layer disposed between the plurality of outer layers so as to surround the outer circumferential surface of the at least one outer layer,
The auxiliary outer layer is a blood vessel for practice with an adjustable interval spaced apart along the longitudinal direction of the structure based on the blood vessel data and the blood flow data.

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