KR102351218B1 - Antimicrobial composition comprising natural extract as an active ingredient and uses thereof - Google Patents

Abstract

Anem arrhena, green tea (Camellia sinensis), Schisandra chinensis, Asa rum siebodii MIQ, sagebrush (Magnolia officinalis), astragalus (Astragalus membranaceus), sea urchin (Lespedeza cuneata), cordata), when using a mixed extract including a mixed extract of Artemisia princeps and Punica granatum extract as an active ingredient, Pseudomonas, Candida, Escherichia, By confirming that it can effectively inhibit the growth of the genus Bacillus and Staphylococcus, it can be usefully used in antibacterial and cosmetic compositions instead of chemical antibiotics, so that it can be usefully used in related industries can

Description

Antimicrobial composition comprising natural extract as an active ingredient and uses thereof

The present invention relates to an antibacterial composition comprising a natural extract as an active ingredient and a use thereof.

Antibiotics are metabolites produced by microorganisms, which are substances that inhibit or kill the growth of other microorganisms in small amounts.

Antibiotics are generally antibiotics extracted from fungi, including antibacterial antibiotics such as penicillin and cephalosporin, and antifungal antibiotics such as griseofulvin and fucidin. As antibiotics extracted from , macrolides, aminoglycosides, tetracyclines, and mycins such as chloramphenicol exist. In the case of penicillin, there are fewer side effects than other antibiotics, but some bacteria produce enzymes that decompose penicillin, so artificially synthesized methicillin or oxacillin are used together.

Among the antibiotics developed so far, the world's most powerful antibiotic is vancomycin. have been used to However, due to the abuse of antibiotics, the so-called super bacteria, which developed the ability to resist pathogens on their own, gradually became stronger and became able to resist any antibiotic, first appeared in Japan in 1996. A problem has occurred.

It can be a natural mutant that can overcome antibiotics, and these resistant bacteria transfer the resistance gene to other bacteria, so the expansion of the resistant bacteria can be done quickly. Super bacteria are typically MRSA (Methicillin-resistant Staphylococcus aureus), VRSA (Vancomycin-resistant Staphylococcus aureus), and VRE (Vancomycin-resistant Enterococci), which have stronger antibiotic resistance, and antibiotic-resistant bacteria are resistant to antibiotics. The need for research on superbacteria is increasing, with resistance gradually increasing to be able to resist any antibiotic, and about 19,000 people a year in the United States alone are killed by antibiotic-resistant bacteria called superbacteria.

In addition, most of the currently used antibiotics are manufactured through chemical synthesis, which is expensive and causes side effects. When new antibiotics are produced through chemical synthesis, during the preclinical period to prove safety, new Bacteria that are resistant to one antibiotic may occur, which has many limitations, such as not being able to achieve a great effect.

Therefore, recently, research to isolate new antibacterial substances from natural products is being actively conducted. In order to separate new antibacterial substances from natural products, natural products have a wide antibacterial spectrum, no side effects even after long-term administration, and safety It must be a proven antibacterial material.

KR 10-1104898 B

An object of the present invention for solving the above problems is, jimo (Anem arrhena), green tea (Camellia sinensis), Schisandra chinensis, Sesin (Asa rum siebodii MIQ), Hubak (Magnolia officinalis), Astragalus membranaceus (Astragalus membranaceus) ), bisuri (Lespedeza cuneata), eoseongcho (Houttuynia cordata), ayeop (Artemisia princeps) and pomegranate skin (Punica granatum) to provide an antibacterial cosmetic composition comprising a mixed extract as an active ingredient.

Another object of the present invention is to provide an antibacterial food composition comprising, as an active ingredient, a mixed extract of Zimo, green tea, omija, sesin, squash, astragalus, bisuri, eoseongcho, aeyeop and pomegranate skin extract.

Another object of the present invention is to provide an antibacterial feed composition comprising, as an active ingredient, a mixed extract of Zimo, green tea, Schisandra, sesin, squash, astragalus, bisu, eoseongcho, aeyeop and pomegranate skin extract.

Another object of the present invention is to provide an antibacterial biological pesticide composition comprising, as an active ingredient, a mixed extract of Zimo, green tea, Schisandra, Sesin, Hubak, Astragalus, Bisuri, Eosongcho, Ayeop and pomegranate extract.

In order to achieve the above object, the present invention provides anemone (Anem arrhena), green tea (Camellia sinensis), Schisandra chinensis, Sesin (Asa rum siebodii MIQ), sagebrush (Magnolia officinalis), Astragalus membranaceus, non-surrey (Lespedeza cuneata), eoseongcho (Houttuynia cordata), ayeop (Artemisia princeps) and pomegranate skin (Punica granatum) provides an antibacterial cosmetic composition comprising a mixed extract as an active ingredient.

In addition, the present invention provides a food composition for antibacterial comprising a mixed extract of Zimo, green tea, omija, sesin, sagebrush, astragalus, bisu, eoseongcho, aeyeop and pomegranate skin extract as an active ingredient.

In addition, the present invention provides an antibacterial feed composition comprising, as an active ingredient, a mixed extract of Zimo, green tea, Schisandra, Sesin, Hucifera, Astragalus, Bisuri, Eoseongcho, Ayeop and pomegranate skin extract.

In addition, the present invention provides an antibacterial biological pesticide composition comprising a mixed extract of Zimo, green tea, omija, sessin, sagebrush, astragalus, bisu, eoseongcho, ayeop and pomegranate skin extract as an active ingredient.

Anem arrhena, green tea (Camellia sinensis), Schisandra chinensis, Asa rum siebodii MIQ, sagebrush (Magnolia officinalis), astragalus (Astragalus membranaceus), sea urchin (Lespedeza cuneata), cordata), when using a mixed extract including a mixed extract of Artemisia princeps and Punica granatum extract as an active ingredient, Pseudomonas, Candida, Escherichia, By confirming that it can effectively inhibit the growth of the genus Bacillus and Staphylococcus, it can be usefully used in antibacterial and cosmetic compositions instead of chemical antibiotics, so that it can be usefully used in related industries can

1 is Candida albicans of the first mixed extract of the present invention, Escherichia coli, Bacillus cereus (Bacillus cereus), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Staphylococcus aureus It is a diagram confirming the antibacterial effect on Staphylococcus aureus.
2 is a view confirming the antibacterial effect of the second mixed extract of the present invention on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa.

The present invention relates to Zimo (Anem arrhena), green tea (Camellia sinensis), Schisandra chinensis (Schisandra chinensis), Sesin (Asa rum siebodii MIQ), Hobak (Magnolia officinalis), Astragalus membranaceus (Astragalus membranaceus), Beast lily (Lespedeza cuneata), cordata), aeyeop (Artemisia princeps) and pomegranate skin (Punica granatum) provides an antibacterial cosmetic composition comprising a mixed extract as an active ingredient.

As used in the present invention, the term “antibacterial” refers to an action of inhibiting the growth of bacteria and fungi by drugs or physiologically active substances, and refers to an action of inhibiting the growth of bacteria and fungi included in antibiotics and natural plant extracts produced by bacteria.

According to an embodiment of the present invention, the extract is gilgyeong, cinnamon, baekbokryeong, angelica, jade porridge, cheonflower powder, ahchul, loofah, reishi, lemon, maekmundong, ginseng, motherwort, chamomile, licorice, wasong, hongsang, sangbaekpi, lavender, It may further include any one or more extracts selected from the group consisting of rosin and seokchangpo.

The antibacterial composition of the present invention may be used as a preservative (antibacterial material) for bacteria, including bacteria that are harmful to food, cosmetics, and pharmaceuticals, or bacteria including antibiotic-resistant Staphylococcus aureus, and may be included in animal feed instead of existing antibiotics.

The antibacterial composition according to the present invention is formulated in the form of oral dosage forms such as powders, granules, tablets, capsules, suspensions, emulsions, syrups and aerosols, external preparations, suppositories, or sterile injection solutions according to conventional methods, respectively. can be used

Specifically, in the case of formulation, it can be prepared using a diluent or excipient such as a filler, extender, binder, wetting agent, disintegrant, surfactant, etc. usually used. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc., and such solid preparations include at least one excipient in the antibacterial composition containing luteolin as an active ingredient, for example, starch, calcium carbonate It can be prepared by mixing (calcium carbonate), sucrose, lactose, gelatin, etc. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Liquid formulations for oral use include suspensions, internal solutions, emulsions, and syrups. In addition to commonly used simple diluents such as water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included. have. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, lyophilized formulations and suppositories. Non-aqueous solvents and suspending agents include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, and the like can be used.

The antibacterial composition according to the present invention may vary depending on the age, sex, and weight of the patient, but generally in an amount of 0.01 to 50 mg/kg, preferably in an amount of 0.1 to 10 mg/kg, once to several times a day. It can be administered in divided doses. In addition, the dosage of luteolin may be increased or decreased according to the route of administration, the degree of disease, sex, weight, age, and the like. Therefore, the above dosage does not limit the scope of the present invention in any way.

The antibacterial composition of the present invention may be administered to mammals such as rats, mice, and livestock by various routes. Any mode of administration can be envisaged, for example, by oral, rectal or intravenous, intramuscular, subcutaneous, endometrial or intracerebrovascular injection.

According to an embodiment of the present invention, the composition may be water or a C1 to C4 lower alcohol and 10-95% by volume lower alcohol aqueous solution extract.

According to an embodiment of the present invention, the composition may inhibit the growth of bacteria, and the bacteria are Pseudomonas, Candida, Escherichia, Bacillus. And it may be at least one member selected from the group consisting of Staphylococcus, but is not limited thereto.

According to an embodiment of the present invention, the bacteria are Pseudomonas aeruginosa, Candida albicans, Escherichia coli, Bacillus cereus and Staphylococcus aureus. It may be any one or more strains selected from the group consisting of Staphylococcus aureus, but is not limited thereto.

According to an embodiment of the present invention, the bacteria may further include antibiotic-resistant bacteria.

The composition comprising the active ingredient of the present invention can be used in various ways, such as for preventing or improving bacterial infectious or antibiotic-resistant bacteria. Products to which the present composition can be added include, for example, cosmetics such as various creams, lotions, skins, essences, and the like, shampoos, conditioners, cleansing agents, face washes, soaps, treatments, packs, and cosmetics.

The cosmetic of the present invention includes a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingolipids, and seaweed extracts.

As the water-soluble vitamin, any one can be used as long as it can be formulated in cosmetics. Preferably, vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, vitamin H, etc. are mentioned. Also, their salts (thiamine hydrochloride, sodium ascorbate salt, etc.) and derivatives (ascorbic acid-2-phosphate sodium salt, ascorbic acid-2-phosphate magnesium salt, etc.) are also included in the water-soluble vitamins that can be used in the present invention. Included. Water-soluble vitamins can be obtained by conventional methods such as a microbial transformation method, a purification method from a microbial culture, an enzymatic method, or a chemical synthesis method.

The oil-soluble vitamin may be any as long as it can be formulated in cosmetics, but preferably includes vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-alpha tocopherol), etc. , their derivatives (ascorbine palmitate, ascorbine stearate, ascorbine dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherol nicotinic acid, vitamin E, DL-pantothenyl alcohol, D-pantothenyl alcohol, pantothenyl ethyl ethers, etc.) are also included in the oil-soluble vitamins used in the present invention. Oil-soluble vitamins can be obtained by conventional methods such as a microbial transformation method, a purification method from a microbial culture, and an enzyme or chemical synthesis method.

The macromolecular peptide may be any type of peptide as long as it can be formulated in cosmetics. Preferably, collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, keratin, and the like are mentioned. Polymeric peptides can be purified and obtained by conventional methods such as purification from a microbial culture solution, enzyme method or chemical synthesis method, or can be purified and used from natural products such as dermis of pigs or cattle, silk fiber of silkworms, etc.

The high molecular weight polysaccharide may be any compound as long as it can be formulated in cosmetics, but preferably hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate, or a salt thereof (such as sodium salt). For example, chondroitin sulfate or a salt thereof can be purified and used from mammals or fish.

The sphingolipid may be any as long as it can be formulated in cosmetics, and ceramide, phytosphingosine, sphingoglycolipid and the like are preferred. Sphingo lipids can be purified by conventional methods from mammals, fish, shellfish, yeast or plants, or can be obtained by chemical synthesis.

The seaweed extract may be any type as long as it can be formulated in cosmetics, but preferably brown algae extract, red algae extract, green algae extract, etc., and calrageenan purified from these seaweed extracts, arginic acid, sodium alginate, Potassium alginate and the like are also included in the seaweed extract used in the present invention. The seaweed extract can be obtained by purification from seaweed by a conventional method.

In the cosmetic of the present invention, in addition to the above essential ingredients, other ingredients usually blended in cosmetics may be blended as needed. Other ingredients that may be added include oils and fats, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, UV absorbers, preservatives, disinfectants, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, A blood circulation promoter, a cooling agent, a restrictive agent, purified water, etc. are mentioned. Examples of the fats and oils include ester fats and oils, hydrocarbon oils, silicone oils, fluorine oils, animal fats, and vegetable oils.

As ester-based fats and oils, tri2-ethylhexanoate glyceryl, 2-ethylhexanoate cetyl, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, stearic acid Butyl, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine Diisopropyl acid, isoalkyl neopentanoate, tri (caprylic acid, capric acid) glyceryl, trimethylol propane tri2-ethylhexanoate, trimethylol propane triisostearate, tetra 2-ethylhexanoate pentaellithritol , cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinoleate, isostea laurate Lil, isotridecyl myristate, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl linoleate, isostearate isopropyl, 2-ethylhexanoate cetoster Aryl, 2-ethyl hexanoate stearyl, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicapric acid, di(caprylic acid, capric acid) propylene glycol, dicaprylic acid propylene glycol, dicaprylate Neopentyl glycol phosphate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, octyldodecyl neopentanoate, isostea octanoate Reel, octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerol oleate ester, polyglycerol isostearate ester , triisocetyl citrate, triisoalkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyldecyl lactate, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, mal Diisostearyl acid, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, sebacic acid Dioctyl, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, phytsteryl isostearate, phytsteryl oleate, 12 -ester types, such as stealoylhydroxy stearate isocetyl, 12-stealoyl hydroxy stearate stearyl, and 12-stealoyl hydroxy stearate isostearyl, etc. are mentioned.

Examples of hydrocarbon-based oils and fats include hydrocarbon-based oils and fats such as squalene, liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybudene, microcrystalline wax, petrolatum, and the like.

Examples of silicone oils and fats include polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane and methylcetyloxysiloxane copolymer, dimethylsiloxane and methylstealloxysiloxane copolymer, alkyl Modified silicone oil, amino modified silicone oil, etc. are mentioned.

Perfluoropolyether etc. are mentioned as fluorine-type fats and oils.

As animal or vegetable oils, avocado oil, almond oil, olive oil, sesame oil, rice bran oil, saffron oil, soybean oil, corn oil, rapeseed oil, passerine oil, palm kernel oil, palm oil, castor oil, sunflower oil, grape seed oil , cottonseed oil, palm oil, kukui nut oil, wheat germ oil, rice germ oil, shea butter, moonflower colostrum, marker damian nut oil, meadow home oil, egg yolk oil, tallow oil, horse oil, mink oil, orange rapie oil, jojoba oil , animal or plant oils and fats such as candelabra wax, carnauba wax, liquid lanolin, and hydrogenated castor oil.

Examples of the moisturizing agent include a water-soluble low-molecular moisturizer, a fat-soluble molecular moisturizer, a water-soluble polymer, and a fat-soluble polymer.

As water-soluble low molecular weight moisturizers, serine, glutamine, sorbitol, mannitol, pyrrolidone-sodium carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (polymerization degree n = 2 or more), polypropylene glycol (degree of polymerization n = 2 or more), polyglycerol B (degree of polymerization n = 2 or more), lactic acid, lactic acid salt, etc. are mentioned.

Cholesterol, cholesterol ester, etc. are mentioned as a fat-soluble low molecular weight humectant.

Examples of the water-soluble polymer include carboxyvinyl polymer, polyaspartate, tragacanth, xanthan gum, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, water-soluble chitin, chitosan, and dextrin. can

Examples of the fat-soluble polymer include polyvinylpyrrolidone and eicocene copolymer, polyvinylpyrrolidone and hexadecene copolymer, nitrocellulose, dextrin fatty acid ester, and high molecular weight silicone. Examples of the emollient include long-chain acylglutamic acid cholesteryl ester, hydroxystearic acid cholesteryl, 12-hydroxystearic acid, stearic acid, rosin acid, and lanolin fatty acid cholesteryl ester.

Nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, etc. are mentioned as surfactant.

Nonionic surfactants include self-emulsifying glycerin monostearate, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerol fatty acid ester, sorbitan fatty acid ester, POE (polyoxyethylene) sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE Glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hydrogenated castor oil, POE castor oil, POE and POP (polyoxyethylene and polyoxypropylene) copolymer, POE and POP alkyl ether, polyether-modified silicone, lauric acid alkanolamides, alkylamine oxides, hydrogenated soybean phospholipids, and the like.

Examples of anionic surfactants include fatty acid soap, alpha-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate, alkyl amide sulfate, alkyl phosphate, POE alkyl phosphate, alkyl amide. phosphate, alkyloylalkyltaurine salt, N-acylamino acid salt, POE alkylether carboxylate, alkylsulfosuccinate salt, alkylsulfoacetate sodium, acylated hydrolyzed collagen peptide salt, perfluoroalkylphosphate ester, etc. have.

Examples of the cationic surfactant include alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, chloride Benzalkonium, diethylaminoethylamide stearate, dimethylaminopropylamide stearate, quaternary ammonium salt of lanolin derivative, etc. are mentioned. Examples of the amphoteric surfactant include carboxybetaine type, amidebetaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amidamine type, etc. Amphoteric surfactant etc. are mentioned.

Examples of organic and inorganic pigments include silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, bengala, clay, bentonite, titanium-coated mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, aluminum oxide. inorganic pigments such as calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine blue, chromium oxide, chromium hydroxide, calamine, and complexes thereof; Polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluororesin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene and styrene copolymer; and organic pigments such as silk powder, cellulose, CI pigment yellow and CI pigment orange, and composite pigments of these inorganic pigments and organic pigments.

Examples of the organic powder include metal soaps such as calcium stearate; alkyl phosphate metal salts such as sodium cetylate, zinc laurylate, and calcium laurylate; acylamino acid polyvalent metal salts such as calcium N-lauroyl-beta-alanine, zinc N-lauroyl-beta-alanine, and calcium N-lauroyl glycine; amidesulfonic acid polyvalent metal salts such as calcium N-lauroyl-taurine and calcium N-palmitoyl-taurine; N such as N-epsilon-lauroyl-L-lysine, N-epsilon-palmitoylizine, N-alpha-paritoylolnithine, N-alpha-lauroylarginine, N-alpha-hydrogenated beef fatty acid acylarginine, etc. -Acyl basic amino acid; N-acyl polypeptides, such as N-lauroyl glycyl glycine; alpha-amino fatty acids such as alpha-aminocaprylic acid and alpha-aminolauric acid; Polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene and a styrene copolymer, ethylene tetrafluoride, etc. are mentioned.

As UV absorbers, para-aminobenzoic acid, para-aminobenzoic acid ethyl, para-aminobenzoate amyl, para-aminobenzoate octyl, salicylate ethylene glycol, salicylate phenyl, octyl salicylate, benzyl salicylate, butyl salicylate, homomentyl salicylate, benzyl cinnamate , Para-methoxycinnamic acid-2-ethoxyethyl, para-methoxycinnamic acid octyl, dipara-methoxycinnamic acid mono-2-ethylhexaneglyceryl, para-methoxycinnamic acid isopropyl, diisopropyl and diisopropyl cinnamic acid ester mixture, Urocanic acid, ethyl urokanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and salts thereof, dihydroxymethoxybenzophenone, sodium dihydroxymethoxybenzophenonedisulfonate, dihydroxybenzo Phenone, tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxydibenzoylmethane, 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)- 1,3,5-triazine, 2-(2-hydroxy-5-methylphenyl) benzotriazole, etc. are mentioned.

Examples of disinfectants include hinokitiol, triclosan, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, zinc phyllithione, benzalkonium chloride, photosensitizer. So, No. 301, mononitroguaial sodium, undecyrenic acid, etc. are mentioned.

Examples of the antioxidant include butylhydroxyanisole, propyl gallic acid, and ellisorbic acid.

Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, fmalic acid, sodium fumarate, succinic acid, sodium succinate, sodium hydroxide, sodium monohydrogen phosphate, and the like.

As alcohol, higher alcohols, such as cetyl alcohol, are mentioned.

In addition, the mixing|blending component which may be added other than this is not limited to this, Moreover, any said component can be mix|blended within the range which does not impair the objective and effect of this invention.

The cosmetic of the present invention may take the form of a solution, an emulsion, a viscous mixture, or the like.

Components included in the cosmetic composition of the present invention may include components commonly used in cosmetic compositions as active ingredients, for example, conventional adjuvants and carriers such as stabilizers, solubilizers, vitamins, pigments and fragrances. include

The antibacterial cosmetic composition of the present invention may be prepared in any formulation conventionally prepared in the art, for example, emulsions, creams, lotions, packs, foundations, lotions, cosmetic liquids, hair cosmetics, and the like.

Specifically, the cosmetic composition of the present invention is a skin lotion, skin softener, skin toner, milk lotion, astringent, lotion, moisture lotion, nourishing lotion, massage cream, nourishing cream, moisture cream, hand cream, foundation, essence, nourishing essence, Includes formulations of packs, soaps, cleansing foams, cleansing lotions, cleansing creams, hair lotions, hair tonics, hair essences, hair shampoos, hair conditioners, hair treatments, body lotions and body cleanser.

When the formulation of the present invention is a paste, cream or gel, animal fiber, vegetable fiber, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additional chlorofluorohydrocarbon, propane /may contain propellants such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylglycol oil, glycerol fatty esters, fatty acid esters of polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxide, bentonite, agar or tracanth may be used.

When the formulation of the present invention is a surfactant-containing cleansing agent, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide as carrier components Ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, linolin derivative or ethoxylated glycerol fatty acid ester and the like may be used.

In addition, the present invention, Zimo (Anem arrhena), green tea (Camellia sinensis), Schisandra chinensis, Sesin (Asa rum siebodii MIQ), Hubak (Magnolia officinalis), Astragalus membranaceus, Bisuri (Lespedeza cuneata), Eoseongcho (Houttuynia cordata), ayeop (Artemisia princeps) and pomegranate skin (Punica granatum) provides an antibacterial food composition comprising a mixed extract as an active ingredient.

The food composition of the present invention may contain various flavoring agents or natural carbohydrates as additional ingredients like a conventional food composition in addition to containing the active ingredient, which is an active ingredient.

Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose and the like; disaccharides such as maltose, sucrose and the like; and polysaccharides such as conventional sugars such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. The above-mentioned flavoring agents can advantageously use natural flavoring agents (Taumatine), stevia extract (eg rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.). The food composition of the present invention may be formulated in the same manner as the pharmaceutical composition and used as a functional food or added to various foods. Foods to which the composition of the present invention can be added include, for example, beverages, meat, chocolate, foods, confectionery, pizza, ramen, other noodles, gums, candy, ice cream, alcoholic beverages, vitamin complexes and health supplements. There is this.

In addition, the food composition includes, in addition to the active ingredient extract, various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic and natural flavoring agents, coloring agents and thickeners (cheese, chocolate, etc.), pectic acid and salts thereof, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. In addition, the food composition of the present invention may contain natural fruit juice and pulp for the production of fruit juice beverages and vegetable beverages.

The functional food composition of the present invention may be manufactured and processed in the form of tablets, capsules, powders, granules, liquids, pills, etc. for the purpose of preventing or treating ischemic brain damage. In the present invention, the term 'health functional food composition' refers to food manufactured and processed using raw materials or ingredients useful for the human body according to Act No. 6727 of the Health Functional Food Act, and It refers to ingestion for the purpose of obtaining useful effects for health purposes such as regulating nutrients or physiological effects. The health functional food of the present invention may contain normal food additives, and unless otherwise specified, whether it is suitable as a food additive is related to the item according to the general rules and general test method of food additives approved by the Food and Drug Administration. It is judged according to the standards and standards. The items listed in the 'Food Additives Code' include, for example, chemical compounds such as ketones, glycine, calcium citrate, nicotinic acid, and cinnamic acid; natural additives such as persimmon pigment, licorice extract, crystalline cellulose, high pigment, and guar gum; Mixed preparations, such as a sodium L-glutamate preparation, a noodle-added alkali agent, a preservative preparation, and a tar color preparation, etc. are mentioned. For example, a health functional food in tablet form is granulated by a conventional method by mixing the active ingredient of the present invention with an excipient, binder, disintegrant and other additives, followed by compression molding with a lubricant, etc., or The mixture may be compression molded directly. In addition, the health functional food in the form of tablets may contain a corrosive agent and the like, if necessary. Among health functional foods in capsule form, hard capsules can be prepared by filling a mixture of the active ingredient of the present invention with additives such as excipients in a conventional hard capsule. It can be prepared by filling the mixture mixed with the capsule base such as gelatin. The soft capsules may contain a plasticizer such as glycerin or sorbitol, a colorant, a preservative, and the like, if necessary. A health functional food in the form of a ring can be prepared by molding a mixture of the active ingredient of the present invention with an excipient, a binder, a disintegrant, etc. by a known method, Alternatively, the surface may be coated with a material such as starch or talc. The health functional food in the form of granules can be prepared in granular form by a conventionally known method by mixing a mixture of the active ingredient excipients, binders, disintegrants, etc. of the present invention, and may contain flavoring agents, flavoring agents, etc. as needed can

In addition, the present invention, Zimo (Anem arrhena), green tea (Camellia sinensis), Schisandra chinensis, Sesin (Asa rum siebodii MIQ), Hubak (Magnolia officinalis), Astragalus membranaceus, Bisuri (Lespedeza cuneata), Eoseongcho (Houttuynia cordata), Ayeop (Artemisia princeps) and pomegranate skin (Punica granatum) provides an antibacterial feed composition comprising a mixed extract as an active ingredient.

The feed composition of the present invention replaces the existing antibiotics and inhibits the growth of harmful food pathogens, so it is expected to improve the health of the animal body, improve the weight gain and meat quality of livestock, and increase the milk production and immunity. can The feed composition of the present invention may be prepared in the form of fermented feed, compound feed, pellet form, silage, and the like. The fermented feed may be prepared by fermenting organic matter by adding various microbial groups or enzymes other than the peptide of the present invention, and the compounded feed may be prepared by mixing several types of general feed and the peptide of the present invention. The feed in the form of pellets can be prepared by applying heat and pressure to the blended feed, etc. in a pellet machine, and silage can be prepared by fermenting the feed with a microorganism according to the present invention. Wet fermented feed collects and transports organic matter such as food waste, mixes excipients for sterilization and moisture control in a certain ratio, and ferments it at a temperature suitable for fermentation for 24 hours or more so that the moisture content is about 70%. It can be adjusted and manufactured. Fermented dry feed can be prepared by adjusting the moisture content of the wet fermented feed to 30% to 40% through an additional drying process.

The feed composition of the present invention may further include a component added to a conventional feed. Examples of the ingredients added to such feed may include cereal powder, meat powder, and beans. In the above, the grain powder may be one or more selected from rice flour, wheat flour, barley flour, and corn flour. In the above, the meat powder may be a meat powder obtained by pulverizing any one or more selected from chicken, beef, pork, and ostrich meat. In the above-mentioned beans, one or more selected from soybeans, kidney beans, peas, and black beans may be used.

In the feed composition of the present invention, any one or more selected from nutrients and minerals may be added to the feed composition in addition to the above-mentioned ingredients added to conventional feed, such as grain powder, meat powder, and beans, to increase the nutritional value of the feed, and feed quality It may include at least one selected from an antifungal agent, an antioxidant, an anticoagulant, an emulsifier, and a binder in order to prevent the deterioration.

In addition, the present invention, Zimo (Anem arrhena), green tea (Camellia sinensis), Schisandra chinensis, Sesin (Asa rum siebodii MIQ), Hubak (Magnolia officinalis), Astragalus membranaceus, Bisuri (Lespedeza cuneata), Eoseongcho (Houttuynia cordata), Ayeop (Artemisia princeps) and pomegranate skin (Punica granatum) provides an antibacterial biological pesticide composition comprising an extract as an active ingredient.

As used herein, the term "biotic pesticide" refers to a drug that uses natural enemy insects, natural enemy microorganisms, antagonistic microorganisms, etc. to spray or radiate in the same form as chemical pesticides to control pests and weeds. , includes biological pesticides for controlling pests such as natural enemy microorganisms, biological pesticides for disease control that kill sclerotia, biological pesticides for weed control, and the like.

As used herein, the term "composition for auxiliary biological pesticides" refers to the above-mentioned biological pesticides for controlling pests, biological pesticides for controlling diseases, and water pesticides for controlling weeds. means a composition that

The composition may be coated on a medical device, medical material, or medical implant. As an example, the coating composition may be used to coat biologically-derived tissues or organs such as skin and teeth, and various medical facilities, equipment, instruments, lenses, artificial valves, pacemakers, and surgical instruments that are temporary or permanent artificial implants. Medical articles such as pins, insertion catheters, and catheters may be coated, but the scope of the present invention is not limited thereto.

Hereinafter, the present invention will be described in detail by way of formulation examples and examples. However, these examples are for describing the present invention in detail, and the scope of the present invention is not limited to these examples.

Example 1. Preparation of mixed extract and confirmation of antibacterial action

<Example 1-1> Preparation of the first mixed extract and confirmation of antibacterial action

In addition to the basic extracts purchased from the Internet herbal market, Zimo, green tea, Schisandra, Sesin, Hubak, Astragalus, Bisuri, Eoseongcho, Ayeop, and pomegranate peel, as additional extracts, Gilgyeong, Cinnamon, Baekbokryeong, Angelica, Jade porridge, Cheonhwabun, Achul, Loofah, 100 g each of reishi, lemon, maekmundong, ginseng, motherwort, chamomile, licorice, wasong, red ginseng, sangbaekpi, lavender, rosin, and seokchangpo was added, and 31.6 parts by weight of alcohol was used to extract 2L each for 20 days. After 2 hours of extraction at 50°C with an ultrasonic processor (KODO, Hwaseong, Korea, output 1,200 W, frequency of 28 KHz), hot water extraction at 65-85°C for 2 hours, filtration, and green tea, sessin, jimo, hubark, hwanggi, bisuri , Eoseongcho, Ayeop, Gilgyeong, Cinnamon, Baekbokryeong, Angelica, Jade porridge, Cheonflowerbun, Ahchul, Loofah, Youngji, Maekmundong, Ginseng, Motherwort, Chaseoncho, Licorice, Wasong, Red ginseng, Sangbaekpi, Lavender, Pine and Seokchang extract were mixed in equal amounts. . 40 parts by weight of the basic extract and additional extracts were mixed with 20 parts by weight of pomegranate skin, 20 parts by weight, 20 parts by weight of Schisandra, 20 parts by weight of lemon, with different weight ratios among the composition of the basic extract and additional extract to obtain a first mixed extract of natural products. obtained.

In order to confirm the antibacterial activity of the extracted first mixed extract, 5 strains (Pseudomonas aeruginosa), Candida albicans, Escherichia coli (Escherichia coli), Bacillus cereus (Bacillus) cereus) and Staphylococcus aureus) were cultured at 30°C or 37°C for 1-2 days, respectively, and absorbance was measured and calculated to be 1×10 ² CFU, 1×10 ³ CFU, respectively. , Each of the five strains was evenly spread on a solid medium (Nutrient agar), and cultured at 37° C. using an incubator for 2-3 days. After that, 40 μl of the mixed extract prepared in Example 1-1 was soaked in a paper disk (diameter 8 mm, thickness 1.5 mm), and then incubated at room temperature for one day. After incubation, the antibacterial activity was confirmed by measuring the diameter of a transparent ring in which no bacteria grew around the paper disk.

As a result, as shown in FIG. 1, the size of the transparent ring confirmed in the first mixed extract is Candida albicans 1×10 ² CFU 16mm, 1×10 ³ CFU 20mm, and Escherichia coli (Escherichia) coli) 1×10 ² CFU 21mm and 1×10 ³ CFU 20mm. Bacillus cereus 1×10 ² CFU 20mm, 1×10 ³ CFU 20mm, Pseudomonas aeruginosa 1×10 ² CFU 18mm, 1×10 ³ CFU 20mm, Staphylococcus aureus It was confirmed that it was 1×10 ² CFU 20mm and 1×10 ^{3 CFU 22mm of Staphylococcus aureus.}

Therefore, it was confirmed that the first mixed extract of the present invention has excellent antibacterial effect against major bacteria.

<Example 1-2> Preparation of the second mixed extract and confirmation of antibacterial action

Zimo, green tea, omija, sesin, peppermint, astragalus, bisuri, eoseongcho, ayeop, pomegranate, gilgyeong, cinnamon, baekbokryeong, angelicae, jade porridge, cheonhwabun, ahchul, loofah, reishi, lemon, maekmundong, ginseng, 100 g each of motherwort, chamomile, licorice, wasong, red ginseng, sagebrush, lavender, rosin, and seokchangpo were added and extracted for 20 days using 2L of 31.6 parts by weight of alcohol each, followed by an ultrasonic processor (KODO, Hwaseong, Korea, output 1,200 W, frequency) 28 KHz) at 50°C for 2 hours, followed by hot water extraction at 65-85°C for 2 hours. Then, each filtered and concentrated under reduced pressure by 2.5 times, 3.94 parts by weight of Zimo extract, 3.94 parts by weight of green tea extract, 3.94 parts by weight of Schisandra extract, 3.94 parts by weight of sesin extract, 3.94 parts by weight of husk extract, 3.94 parts by weight of Astragalus extract , 3.94 parts by weight of nonsuri extract, 3.94 parts by weight of Eoseongcho extract, 3.94 parts by weight of aeyeop extract, and 3.94 parts by weight of pomegranate skin extract were prepared. Here, the additional extracts of Gilkyung, cinnamon, Baekbokryeong, Angelica, jade porridge, chrysanthemum, Achul, Loofah, Reishi, Maekmundong, ginseng, Motherwort, chamomile, Licorice, Wasong, Red ginseng, Sangbaekpi, Lavender, Songjin, and Seokchangpo extract are mixed in equal amounts. A second mixed extract was obtained by mixing 20 parts by weight.

Three strains (Escherichia coli, Staphylococcus aureus), Pseudomonas aeruginosa (Pseudomonas) to be subjected to the antimicrobial activity test of the second mixed extract prepared in Example 1-2 aeruginosa)) was cultured at 30 °C or 37 °C for 1-2 days, respectively, absorbance was measured and calculated to be ^{1×10 2} CFU and 1×10 ^{3 CFU.} Each of the three strains was evenly spread on a solid medium (Nutrient agarNutrient agar), and cultured at 37°C using an incubator for 2-3 days. 40 μl of the mixed extract prepared in Formulation Example 2 was soaked in a paper disk (diameter 8 mm, thickness 1.5 mm), and then incubated for one day at room temperature. was confirmed.

As a result, as shown in Figure 2, the size of the clear ring confirmed in the second mixed extract of the present invention was Escherichia coli 1 × 10 ² CFU 12mm, 1 × 10 ³ CFU 16mm, Staphylococcus Aureus (Staphylococcus aureus) 1 × 10 ² CFU 12mm, 1 × 10 ³ CFU 16mm, Pseudomonas aeruginosa (Pseudomonas aeruginosa) 1 × 10 ² CFU 14mm, 1 × 10 ³ CFU was confirmed to be 18mm.

Therefore, it was confirmed that the second mixed extract of the present invention has excellent antibacterial effect against major bacteria.

Therefore, the first and second mixed extracts of the present invention, without antibiotic components, Pseudomonas aeruginosa, Candida albicans, Escherichia coli, Bacillus cereus (Bacillus cereus) ) and Staphylococcus aureus were confirmed to inhibit bacterial growth.

Formulation Example 1. Preparation of antibacterial fragrance cleaner, mist Ⅰ

From the measurement results of the antibacterial effect on each bacteria confirmed in Example 1-1, a composition having an antibacterial effect having the composition shown in Table 1 below was prepared.

Specifically, in the weight ratios shown in Table 1, the basic extracts and additional extracts such as jimo, green tea, omija, sesin, squash, astragalus, bisuri, eoseongcho, aeyeop, pomegranate skin, gilgyeong, cinnamon, baekbokryeong, angelica, jade porridge, cheonhwabun, ahchul, loofah , reishi, lemon, maekmundong, ginseng, motherwort, chamomile, licorice, wasong, red ginseng, sangbaekpi, lavender, rosin, and seokchangpo were extracted. In 20 parts by weight of the basic extract and additional extract, 10 parts by weight of green tea, 10 parts by weight of Schisandra, 10 parts by weight of Eosuri, 10 parts by weight of Zimo, 10 parts by weight of Eosongcho, 10 parts by weight of pomegranate skin Weight parts, 10 parts by weight of lemon, and 10 parts by weight of leaf leaves were mixed to make 0.4L of a mixture of natural products, and then 0.6L of distilled water was mixed. It was aged for about one day to prepare a detergent and mist composition according to the present invention.

Antibacterial mist ingredient table using natural products One Distilled water 60.0 parts by weight 2 Zemo Extract 0.1 to 15 parts by weight 3 green tea extract 0.1 to 15 parts by weight 4 Schisandra extract 0.1 to 15 parts by weight 5 sesin extract 0.1 to 15 parts by weight 6 Pumpkin Extract 0.1 to 15 parts by weight 7 Astragalus extract 0.1 to 15 parts by weight 8 Non-Suri Extract 0.1 to 15 parts by weight 9 Eoseongcho Extract 0.1 to 15 parts by weight 10 leaf extract 0.1 to 15 parts by weight 11 pomegranate skin extract 0.1 to 15 parts by weight 12 Gilkyung Extract 0.1 to 15 parts by weight 13 cinnamon extract 0.1 to 15 parts by weight 14 baekbokryeong extract 0.1 to 15 parts by weight 15 Angelica Extract 0.1 to 15 parts by weight 16 jade porridge extract 0.1 to 15 parts by weight 17 plant pollen extract 0.1 to 15 parts by weight 18 ahchul extract 0.1 to 15 parts by weight 19 Loofah extract 0.1 to 15 parts by weight 20 Reishi extract 0.1 to 15 parts by weight 21 lemon extract 0.1 to 15 parts by weight 22 maekmundong extract 0.1 to 15 parts by weight 23 Ginseng Extract 0.1 to 15 parts by weight 24 motherwort extract 0.1 to 15 parts by weight 25 Tea Spearmint Extract 0.1 to 15 parts by weight 26 Licorice Extract 0.1 to 15 parts by weight 27 wasong extract 0.1 to 15 parts by weight 28 Red Ginseng Extract 0.1 to 15 parts by weight 29 Epiphyllum extract 0.1 to 15 parts by weight 30 lavender extract 0.1 to 15 parts by weight 31 rosin extract 0.1 to 15 parts by weight 32 seokchangpo extract 0.1 to 15 parts by weight Total 100.0 parts by weight

Formulation Example 2. Preparation of antibacterial fragrance cleaner, mist Ⅱ

From the measurement results of the antibacterial effect on each bacteria confirmed in Example 1-2, a cleaning composition having the composition shown in Table 2 below was prepared.

Specifically, 2.4 parts by weight of each of the basic extracts, such as Zimo extract, green tea extract, Schisandra extract, sesin extract, husk extract, Astragalus extract, Bisuri extract, Eoseongcho extract, Aeyeop extract, and pomegranate skin extract were prepared in an amount of 2.4 parts by weight.

Here, the additional extracts of Gilkyung, cinnamon, Baekbokryeong, Angelica, jade porridge, chrysanthemum, Achul, Loofah, Reishi, Maekmundong, ginseng, Motherwort, chamomile, Licorice, Wasong, Red ginseng, Sangbaekpi, Lavender, Songjin, and Seokchangpo extract are mixed in equal amounts. Thus, 12.2 parts by weight was mixed with the basic extract.

In 1L of the above mixture, 9 g was mixed with salt (sea salt, rock salt, lake salt, magnetic salt, refined salt, re-salt, etc.) and packaged in small packages so as to have a concentration of 0.9 parts by weight corresponding to saline solution. It was aged for about one day to prepare a detergent and mist composition according to the present invention.

Antibacterial mist ingredient table using natural products One Distilled water 60.9 parts by weight 2 Zemo Extract 2.4 parts by weight 3 green tea extract 2.4 parts by weight 4 Schisandra extract 2.4 parts by weight 5 sesin extract 2.4 parts by weight 6 Pumpkin Extract 2.4 parts by weight 7 Astragalus extract 2.4 parts by weight 8 Non-Suri Extract 2.4 parts by weight 9 Eoseongcho Extract 2.4 parts by weight 10 leaf extract 2.4 parts by weight 11 pomegranate skin extract 2.4 parts by weight 12 Gilkyung, cinnamon, Baekbokryeong, Angelica, Hwanggi, jade porridge, celery pollen, ahchul, loofah, reishi, lemon, maekmundong, ginseng, motherwort, chamomile, licorice, wasong, red ginseng, sangbaekpi, lavender, rosin, seok iris extract 12.2 parts by weight Total 100.0 parts by weight

Claims (9)

Anem arrhena, Green tea (Camellia sinensis), Schisandra chinensis, Asa rum siebodii MIQ, Magnolia officinalis, Astragalus membranaceus, Beast lily (Lespedeza cuneata), Houttuynia cord Mixed extract of Artemisia princeps and pomegranate skin (Punica granatum) extracts and gilgyeong (Platycodon grandiflorum), cinnamon (Cinnamomum cassia), Baekbokryeong (Pachyma hoelen rumphius), Angelica gigas, jade porridge (Trichosanthes) kirilowii), Achul (Curcuma phaeocaulis), Loofah (Cucumis aegyptica), Ganoderma (Ganoderma lucidum), Lemon (Citrus limon), Liriope platyphylla, Ginseng (Ginseng Radix), Motherwort (Plantago tica), Psyllium (Leonurus japonicus) , Licorice (glcyrrhiza glabra), Wasabi (Orostachys japonica), Echeveria agavoides, Mori cortex, Lavender (Lavendula officinalis), rosin (Japanese Red), and a mixed extract of Acorus gramineus extract as active ingredients Antibacterial cosmetic composition comprising. delete The cosmetic composition for antibacterial according to claim 1, wherein the composition further comprises water or a C1 to C4 lower alcohol. The cosmetic composition for antibacterial according to claim 1, wherein the composition inhibits the growth of bacteria. According to claim 4, wherein the bacteria is Pseudomonas genus (seudomonas), Candida genus (Candida), Escherichia genus (Escherichia), Bacillus genus (Bacillus) and Staphylococcus genus (Staphylococcus) at least one selected from the group consisting of A cosmetic composition for antibacterial that inhibits growth. Anem arrhena, Green tea (Camellia sinensis), Schisandra chinensis, Asa rum siebodii MIQ, Magnolia officinalis, Astragalus membranaceus, Beast lily (Lespedeza cuneata), Houttuynia cord Mixed extract of Artemisia princeps and pomegranate skin (Punica granatum) extracts and gilgyeong (Platycodon grandiflorum), cinnamon (Cinnamomum cassia), Baekbokryeong (Pachyma hoelen rumphius), Angelica gigas, jade porridge (Trichosanthes) kirilowii), Achul (Curcuma phaeocaulis), Loofah (Cucumis aegyptica), Ganoderma (Ganoderma lucidum), Lemon (Citrus limon), Liriope platyphylla, Ginseng (Ginseng Radix), Motherwort (Plantago tica), Psyllium (Leonurus japonicus) , Licorice (glcyrrhiza glabra), Wasabi (Orostachys japonica), Echeveria agavoides, Mori cortex, Lavender (Lavendula officinalis), rosin (Japanese Red), and a mixed extract of Acorus gramineus extract as active ingredients Antibacterial food composition comprising. delete Anem arrhena, Green tea (Camellia sinensis), Schisandra chinensis, Asa rum siebodii MIQ, Magnolia officinalis, Astragalus membranaceus, Beast lily (Lespedeza cuneata), Houttuynia cord Mixed extract of Artemisia princeps and pomegranate skin (Punica granatum) extracts and gilgyeong (Platycodon grandiflorum), cinnamon (Cinnamomum cassia), Baekbokryeong (Pachyma hoelen rumphius), Angelica gigas, jade porridge (Trichosanthes) kirilowii), Achul (Curcuma phaeocaulis), Loofah (Cucumis aegyptica), Ganoderma (Ganoderma lucidum), Lemon (Citrus limon), Liriope platyphylla, Ginseng (Ginseng Radix), Motherwort (Plantago tica), Psyllium (Leonurus japonicus) , Licorice (glcyrrhiza glabra), Wasabi (Orostachys japonica), Echeveria agavoides, Mori cortex, Lavender (Lavendula officinalis), rosin (Japanese Red), and a mixed extract of Acorus gramineus extract as active ingredients Antibacterial feed composition comprising. Anem arrhena, Green tea (Camellia sinensis), Schisandra chinensis, Asa rum siebodii MIQ, Magnolia officinalis, Astragalus membranaceus, Beast lily (Lespedeza cuneata), Houttuynia cord Mixed extract of Artemisia princeps and pomegranate skin (Punica granatum) extracts and gilgyeong (Platycodon grandiflorum), cinnamon (Cinnamomum cassia), Baekbokryeong (Pachyma hoelen rumphius), Angelica gigas, jade porridge (Trichosanthes) kirilowii), Achul (Curcuma phaeocaulis), Loofah (Cucumis aegyptica), Ganoderma (Ganoderma lucidum), Lemon (Citrus limon), Liriope platyphylla, Ginseng (Ginseng Radix), Motherwort (Plantago tica), Psyllium (Leonurus japonicus) , Licorice (glcyrrhiza glabra), Wasabi (Orostachys japonica), Echeveria agavoides, Mori cortex, Lavender (Lavendula officinalis), rosin (Japanese Red), and a mixed extract of Acorus gramineus extract as active ingredients An antibacterial biological pesticide composition comprising.

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