KR102307012B1 - 일주기 리듬 장애의 치료 - Google Patents

일주기 리듬 장애의 치료 Download PDF

Info

Publication number
KR102307012B1
KR102307012B1 KR1020207005338A KR20207005338A KR102307012B1 KR 102307012 B1 KR102307012 B1 KR 102307012B1 KR 1020207005338 A KR1020207005338 A KR 1020207005338A KR 20207005338 A KR20207005338 A KR 20207005338A KR 102307012 B1 KR102307012 B1 KR 102307012B1
Authority
KR
South Korea
Prior art keywords
patient
melatonin
sleep
tasimelteon
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020207005338A
Other languages
English (en)
Korean (ko)
Other versions
KR20200022543A (ko
Inventor
마를렌 미셸 드레스맨
존 조셉 피니
루이스 윌리엄 리카멜레
미하엘 에이치. 폴리메로포울로스
Original Assignee
반다 파마슈티칼즈, 인코퍼레이티드.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47679075&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR102307012(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 반다 파마슈티칼즈, 인코퍼레이티드. filed Critical 반다 파마슈티칼즈, 인코퍼레이티드.
Priority to KR1020217030530A priority Critical patent/KR102411809B1/ko
Publication of KR20200022543A publication Critical patent/KR20200022543A/ko
Application granted granted Critical
Publication of KR102307012B1 publication Critical patent/KR102307012B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2864—Sleep disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medical Informatics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Primary Health Care (AREA)
  • Databases & Information Systems (AREA)
KR1020207005338A 2012-01-26 2013-01-25 일주기 리듬 장애의 치료 Active KR102307012B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217030530A KR102411809B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
US201261590974P 2012-01-26 2012-01-26
US61/590,974 2012-01-26
US201261640067P 2012-04-30 2012-04-30
US61/640,067 2012-04-30
US201261650455P 2012-05-22 2012-05-22
US201261650458P 2012-05-22 2012-05-22
US61/650,458 2012-05-22
US61/650,455 2012-05-22
US201261714149P 2012-10-15 2012-10-15
US61/714,149 2012-10-15
US201261738985P 2012-12-18 2012-12-18
US201261738987P 2012-12-18 2012-12-18
US61/738,987 2012-12-18
US61/738,985 2012-12-18
US201361755896P 2013-01-23 2013-01-23
US61/755,896 2013-01-23
PCT/US2013/023312 WO2013112949A2 (en) 2012-01-26 2013-01-25 Treatment of circadian rhythm disorders
KR1020197000468A KR20190006598A (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197000468A Division KR20190006598A (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020217030530A Division KR102411809B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료

Publications (2)

Publication Number Publication Date
KR20200022543A KR20200022543A (ko) 2020-03-03
KR102307012B1 true KR102307012B1 (ko) 2021-09-30

Family

ID=47679075

Family Applications (10)

Application Number Title Priority Date Filing Date
KR1020207005338A Active KR102307012B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020217030530A Active KR102411809B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020147022609A Ceased KR20140117537A (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020227020587A Active KR102593047B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020207030707A Active KR102317399B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020147022612A Active KR101895653B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020197016680A Active KR102171965B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020197000468A Ceased KR20190006598A (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020187024907A Ceased KR20180100450A (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020177013613A Ceased KR20170058463A (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료

Family Applications After (9)

Application Number Title Priority Date Filing Date
KR1020217030530A Active KR102411809B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020147022609A Ceased KR20140117537A (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020227020587A Active KR102593047B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020207030707A Active KR102317399B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020147022612A Active KR101895653B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020197016680A Active KR102171965B1 (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020197000468A Ceased KR20190006598A (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020187024907A Ceased KR20180100450A (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료
KR1020177013613A Ceased KR20170058463A (ko) 2012-01-26 2013-01-25 일주기 리듬 장애의 치료

Country Status (21)

Country Link
US (22) US8785492B2 (enExample)
EP (5) EP4502609A3 (enExample)
JP (10) JP2015509106A (enExample)
KR (10) KR102307012B1 (enExample)
CN (4) CN104379135B (enExample)
AU (9) AU2013211880A1 (enExample)
BR (2) BR112014018429A8 (enExample)
CA (4) CA3159064A1 (enExample)
CL (2) CL2014001993A1 (enExample)
CO (2) CO7131366A2 (enExample)
DK (1) DK2806863T3 (enExample)
ES (2) ES2646197T3 (enExample)
HR (1) HRP20171600T1 (enExample)
HU (1) HUE034876T2 (enExample)
IL (6) IL330095A (enExample)
IN (2) IN2014DN07132A (enExample)
MX (4) MX374068B (enExample)
PT (1) PT2806863T (enExample)
RU (2) RU2631602C2 (enExample)
SI (1) SI2806863T1 (enExample)
WO (2) WO2013112951A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101587394B1 (ko) * 2006-05-22 2016-01-21 반다 파마슈티칼즈, 인코퍼레이티드. 멜라토닌 효능제 치료
US8691275B2 (en) 2011-01-28 2014-04-08 Zx Pharma, Llc Controlled-release melatonin compositions and related methods
US9532952B2 (en) 2011-01-28 2017-01-03 Physician's Seal, LLC Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
IL330095A (en) 2012-01-26 2026-08-01 Vanda Pharmaceuticals Inc Tesimalta for use in the treatment of asynchronous circadian rhythm of cortisol
AU2013262631B2 (en) 2012-05-18 2016-02-04 Vanda Pharmaceuticals Inc. Metabolites of (1R-trans)-N-[[2-(2,3-dihydro-4-benzofuranyl) cyclopropyl]methyl]propanamide
IL266159B2 (en) * 2012-12-18 2024-07-01 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
US10376487B2 (en) * 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
US11090285B2 (en) 2013-11-12 2021-08-17 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
WO2015117048A1 (en) * 2014-01-31 2015-08-06 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
CN106604726A (zh) * 2014-09-02 2017-04-26 万达制药公司 用于治疗史密斯‑马吉利综合征的他司美琼
US10076286B1 (en) 2014-10-21 2018-09-18 Verily Life Sciences Llc Methods and devices for circadian rhythm monitoring
WO2016109359A1 (en) * 2014-12-29 2016-07-07 Auspex Pharmaceuticals, Inc. Cyclopropyl dihydrobenzofuran modulators of melatonin receptors
US11013713B2 (en) * 2015-12-15 2021-05-25 Vanda Pharmaceuticals Inc. Method of treatment
EP3400212A1 (en) 2016-01-06 2018-11-14 Auspex Pharmaceuticals, Inc. Tetrahydrocarbazole inhibitors of sirt1 receptors
JP7576905B2 (ja) 2016-05-06 2024-11-01 ソシエテ・デ・プロデュイ・ネスレ・エス・アー バレリアン組成物及び関連方法
CN109862826B (zh) * 2016-08-18 2023-03-21 皇家飞利浦有限公司 血压管理
WO2019028245A1 (en) 2017-08-02 2019-02-07 Vanda Pharmaceuticals Inc. USE OF TASIMELTÉON FOR THE TREATMENT OF AFFECTIVE DISORDERS
EP3761974A1 (en) * 2018-03-04 2021-01-13 Vanda Pharmaceuticals Inc. Treatment of disorders with tasimelteon
CA3050046C (en) 2018-07-23 2026-04-21 Kobold Corporation Sleeve valves, shifting tools and methods for wellbore completion operations therewith
CN108828098B (zh) * 2018-07-24 2020-04-21 山东农业大学 一种高效液相色谱-质谱法测定棉花中褪黑素的方法
JP2022500420A (ja) * 2018-09-12 2022-01-04 バンダ・ファーマシューティカルズ・インコーポレイテッドVanda Pharmaceuticals Inc. 睡眠又は睡眠後パフォーマンスの改善
KR102260252B1 (ko) * 2018-10-24 2021-06-03 주식회사 인코스팜 피부 세포를 통한 일주기 리듬 분석 방법, 일주기 리듬 장애를 정상화하는 방법 및 일주기 리듬 정보를 이용한 정보제공 시스템
CN109522688B (zh) * 2018-10-27 2023-10-13 平安医疗健康管理股份有限公司 基于数据处理的肾功能衰竭资质认证方法、设备及服务器
EP3671757A1 (en) * 2018-12-18 2020-06-24 Koninklijke Philips N.V. System and method for determining a level of alertness
BR112021026463A2 (pt) * 2019-06-29 2022-02-08 Vanda Pharmaceuticals Inc Métodos para identificar um indivíduo a ser tratado por tempo de sono atrasado, para identificar um indivíduo em que o tempo de sono ou fase de sono pode ser atrasada, para identificar um indivíduo a ser tratado para um período circadiano alongado (tau), para identificar um indivíduo como alguém passível de alteração de um período circadiano (tau), e, para identificar um paciente a ser tratado para uma fase de sono atrasado devido ao tratamento com um inibidor de canal de nucleotídeo cíclico ativado por hiperpolarização (hcn)
JP7276787B2 (ja) * 2019-11-25 2023-05-18 株式会社村田製作所 解析システム及び解析方法
NZ811397A (en) 2019-12-13 2025-11-28 Vanda Pharmaceuticals Inc Liquid tasimelteon formulations and methods of use thereof

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL50699A0 (en) 1975-10-28 1976-12-31 Ici America Inc Triazole derivatives
EP0126630B1 (en) 1983-05-18 1987-09-16 Monash University The use of melatonin for the manufacture of a medicament
IL79264A0 (en) 1986-06-27 1986-09-30 Univ Ramot Tryptamine derivatives,pharmaceutical compositions containing them and their use in an assay for melatonin receptors
US4997845A (en) 1987-02-02 1991-03-05 Eli Lilly And Company β-alkylmelatonins as ovulation inhibitors
US5093352A (en) 1988-11-14 1992-03-03 Whitby Research, Inc. Antidepressant agents
US5151446A (en) 1989-09-25 1992-09-29 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
FR2658818B1 (fr) 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5242941A (en) 1990-12-04 1993-09-07 State Of Oregon Methods of treating circadian rhythm disorders
US6638963B1 (en) * 1990-12-04 2003-10-28 Oregon Health And Science University Methods for treating circadian rhythm disorders
IT1251544B (it) 1991-05-13 1995-05-17 Gabriele Biella Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico
US6180657B1 (en) 1993-11-18 2001-01-30 Eli Lilly And Company Melatonin derivatives for use in treating desynchronization disorders
US5403851A (en) 1994-04-05 1995-04-04 Interneuron Pharmaceuticals, Inc. Substituted tryptamines, phenalkylamines and related compounds
GB9416884D0 (en) 1994-08-20 1994-10-12 Danbiosyst Uk Drug delivery compositions
MD1716C2 (ro) 1995-02-01 2002-02-28 Neurim Pharmaceuticals (1991) Ltd. Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine
AU713030B2 (en) 1995-10-24 1999-11-18 Gruenenthal Gmbh Method of adjusting the circadian rhythm of a mammal
KR100499106B1 (ko) 1996-12-10 2005-07-01 브리스톨-마이어즈 스퀴브 컴페니 벤조디옥솔, 벤조퓨란, 디히드로벤조퓨란, 및 벤조디옥산 멜라토닌 작용제
US5776969A (en) 1997-02-27 1998-07-07 Eli Lilly And Company Treatment of sleep disorders
AUPO588297A0 (en) * 1997-03-26 1997-04-24 Luminis Pty Limited Mediation in melatonin production
JP3055884B2 (ja) 1997-08-07 2000-06-26 花野商事株式会社 引きクランプ装置
US6348485B1 (en) 1998-06-09 2002-02-19 Takeda Chemical Industries, Ltd. Method for treating or preventing sleep disorders
US6562858B2 (en) 1999-05-17 2003-05-13 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating depression
PT1189900E (pt) 1999-06-30 2004-05-31 Bristol Myers Squibb Co Derivados de aminopirrolidina heterociclicos utilizados como agentes melatonergicos
CA2463158C (en) 2001-10-30 2013-07-30 Novartis Ag Depot formulations of iloperidone and a star polymer
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
IL155666A (en) 2003-04-29 2013-12-31 Neurim Pharma 1991 Insomnia treatment
JP2005080603A (ja) 2003-09-10 2005-03-31 Kumamoto Technology & Industry Foundation 生体リズム障害の度合の判断方法
US20050137247A1 (en) 2003-12-22 2005-06-23 The Brigham And Women's Hospital, Inc. Methods and compositions for treatment of hypertension
EP1696959A2 (en) 2003-12-24 2006-09-06 Sepracor, Inc. Melatonin combination therapy for improving sleep quality
GB0400031D0 (en) * 2004-01-03 2004-02-04 Univ Sheffield Depression treatment
KR101187461B1 (ko) 2005-07-29 2012-10-02 반다 파마슈티칼즈, 인코퍼레이티드. 각성을 향상시키는 방법
US7754902B2 (en) 2006-05-18 2010-07-13 Vanda Pharmaceuticals, Inc. Ruthenium(II) catalysts for use in stereoselective cyclopropanations
KR101587394B1 (ko) * 2006-05-22 2016-01-21 반다 파마슈티칼즈, 인코퍼레이티드. 멜라토닌 효능제 치료
JP2009538334A (ja) 2006-05-22 2009-11-05 ヴァンダ ファーマシューティカルズ インコーポレイテッド 抑うつ障害のための治療
CA2693992C (en) 2006-07-20 2017-01-31 Somaxon Pharmaceuticals, Inc. Methods of improving the pharmacokinetics of doxepin
CA2658393A1 (en) 2006-07-21 2008-01-24 The Regents Of The University Of California Human endogenous retrovirus polypeptide compositions and methods of use thereof
WO2008070795A2 (en) 2006-12-06 2008-06-12 Somaxon Pharmaceuticals, Inc. Combination therapy using low-dose doxepin for the improvement of sleep
KR20160065998A (ko) 2007-04-11 2016-06-09 바이오마린 파머수티컬 인크. 테트라하이드로바이오프테린 투여 방법, 관련 조성물 및 측정 방법
JP5590676B2 (ja) 2007-09-13 2014-09-17 ヴァンダ ファーマシューティカルズ インコーポレイテッド Ｐｅｒ３ｖｎｔｒ遺伝子型に基づく睡眠パラメータ及び睡眠誘導化合物に対する応答の予測
WO2009084023A2 (en) 2007-10-19 2009-07-09 Glenmark Generics Limited Amorphous ramelteon and process for the preparation thereof
WO2009058261A1 (en) 2007-10-31 2009-05-07 Merck & Co., Inc. Modulation of sleep with nr2b receptor antagonists
JP5558016B2 (ja) 2009-03-17 2014-07-23 株式会社 資生堂 概日リズム調整剤
NZ595428A (en) * 2009-04-07 2013-04-26 Duocourt Pharma Ab Improved glucocorticoid therapy
WO2011009102A1 (en) 2009-07-16 2011-01-20 Vanda Pharmaceuticals Inc. Use of a melatonin agonist for the treatment of sleep disorders including primary insomnia
US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
IL330095A (en) * 2012-01-26 2026-08-01 Vanda Pharmaceuticals Inc Tesimalta for use in the treatment of asynchronous circadian rhythm of cortisol
AU2013262631B2 (en) 2012-05-18 2016-02-04 Vanda Pharmaceuticals Inc. Metabolites of (1R-trans)-N-[[2-(2,3-dihydro-4-benzofuranyl) cyclopropyl]methyl]propanamide
IL266159B2 (en) 2012-12-18 2024-07-01 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
JP6921534B2 (ja) 2014-02-12 2021-08-18 バンダ・ファーマシューティカルズ・インコーポレイテッドＶａｎｄａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 高純度医薬品等級タシメルテオン

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Sleep Med Clin. vol.4, pp.195-211 (2009.).
The Lancet 2009. vol.373, pp.482-491 (2009.).

Also Published As

Publication number Publication date
WO2013112951A3 (en) 2014-12-31
MX374068B (es) 2020-07-30
RU2631602C2 (ru) 2017-09-25
KR20140117537A (ko) 2014-10-07
US20180071245A1 (en) 2018-03-15
US20210205261A1 (en) 2021-07-08
US10945988B2 (en) 2021-03-16
US20140296332A1 (en) 2014-10-02
US20200009106A1 (en) 2020-01-09
MX2020007448A (es) 2020-09-14
AU2021204784A1 (en) 2021-08-05
USRE46604E1 (en) 2017-11-14
US20220168264A1 (en) 2022-06-02
CO7131353A2 (es) 2014-12-01
WO2013112949A3 (en) 2013-09-19
JP6267260B2 (ja) 2018-01-24
BR112014018429A8 (pt) 2017-07-11
JP2020097602A (ja) 2020-06-25
CA3085116C (en) 2022-07-19
US20190070144A1 (en) 2019-03-07
EP2806864B1 (en) 2021-08-25
US20210330634A1 (en) 2021-10-28
US11850229B2 (en) 2023-12-26
CN104379135B (zh) 2020-07-14
CA3085116A1 (en) 2013-08-01
US10980770B2 (en) 2021-04-20
JP2022095662A (ja) 2022-06-28
MX2014009078A (es) 2016-01-25
US11285129B2 (en) 2022-03-29
US20170087123A1 (en) 2017-03-30
HUE034876T2 (hu) 2018-03-28
IL330095A (en) 2026-08-01
MX2019012197A (es) 2020-08-31
JP2019038822A (ja) 2019-03-14
AU2019204306A1 (en) 2019-07-04
JP2017039731A (ja) 2017-02-23
KR20200022543A (ko) 2020-03-03
CN111603460A (zh) 2020-09-01
JP2016172737A (ja) 2016-09-29
KR20170058463A (ko) 2017-05-26
CN110215440A (zh) 2019-09-10
CA2861111A1 (en) 2013-08-01
US12201604B2 (en) 2025-01-21
IN2014DN07132A (enExample) 2015-04-24
EP4502609A2 (en) 2025-02-05
SI2806863T1 (sl) 2017-12-29
US20150216837A1 (en) 2015-08-06
EP3300728A3 (en) 2018-05-02
US9539234B2 (en) 2017-01-10
JP2021073222A (ja) 2021-05-13
US9549913B2 (en) 2017-01-24
IL233715A0 (en) 2014-09-30
US9855241B2 (en) 2018-01-02
ES2646197T3 (es) 2017-12-12
US20170100366A1 (en) 2017-04-13
CN104519877A (zh) 2015-04-15
EP3620794A1 (en) 2020-03-11
EP4502609A3 (en) 2025-04-09
US20240156775A1 (en) 2024-05-16
US20200179326A1 (en) 2020-06-11
US10149829B2 (en) 2018-12-11
IL330098A (en) 2026-08-01
KR101895653B1 (ko) 2018-09-05
WO2013112951A2 (en) 2013-08-01
US9060995B2 (en) 2015-06-23
US11633377B2 (en) 2023-04-25
CA2861108C (en) 2020-09-08
KR102411809B1 (ko) 2022-06-22
US11826339B2 (en) 2023-11-28
KR20190069617A (ko) 2019-06-19
BR112014018433A8 (pt) 2017-07-11
KR102171965B1 (ko) 2020-10-30
KR20180100450A (ko) 2018-09-10
AU2016204217A1 (en) 2016-07-14
IL269054A (en) 2019-10-31
JP7119261B2 (ja) 2022-08-17
US20250161259A1 (en) 2025-05-22
JP2015509106A (ja) 2015-03-26
AU2013211878A1 (en) 2014-08-21
CA2861111C (en) 2021-11-23
PT2806863T (pt) 2017-11-09
US20130197076A1 (en) 2013-08-01
CL2014001992A1 (es) 2015-03-13
CO7131366A2 (es) 2014-12-01
KR20140116927A (ko) 2014-10-06
BR112014018433A2 (enExample) 2017-06-20
AU2019203910A1 (en) 2019-06-20
US11833130B2 (en) 2023-12-05
EP3300728A2 (en) 2018-04-04
DK2806863T3 (en) 2017-10-30
US11918556B2 (en) 2024-03-05
US20140296331A1 (en) 2014-10-02
KR102317399B1 (ko) 2021-10-26
KR20200123873A (ko) 2020-10-30
RU2014134552A (ru) 2016-03-20
WO2013112949A2 (en) 2013-08-01
AU2021204784B2 (en) 2024-11-14
US10449176B2 (en) 2019-10-22
CA3159064A1 (en) 2013-08-01
MX367184B (es) 2019-08-08
US8785492B2 (en) 2014-07-22
US20140357710A1 (en) 2014-12-04
EP2806863B1 (en) 2017-08-09
KR20210118983A (ko) 2021-10-01
HRP20171600T1 (hr) 2017-12-15
US20240197671A1 (en) 2024-06-20
US20220168263A1 (en) 2022-06-02
EP2806864A2 (en) 2014-12-03
AU2019203910B2 (en) 2021-09-23
AU2018201909A1 (en) 2018-04-12
ES2897671T3 (es) 2022-03-02
IL233714A0 (en) 2014-09-30
US20140296330A1 (en) 2014-10-02
US10610510B2 (en) 2020-04-07
RU2650647C2 (ru) 2018-04-16
JP2018080181A (ja) 2018-05-24
EP2806863A2 (en) 2014-12-03
US20210161854A1 (en) 2021-06-03
IN2014DN07050A (enExample) 2015-04-10
AU2013211880A1 (en) 2014-08-21
CN104379135A (zh) 2015-02-25
BR112014018429A2 (enExample) 2017-06-20
CA2861108A1 (en) 2013-08-01
US20220175716A1 (en) 2022-06-09
JP2023071727A (ja) 2023-05-23
MX2014009079A (es) 2016-01-25
KR102593047B1 (ko) 2023-10-24
CL2014001993A1 (es) 2015-03-13
IL269041A (en) 2019-10-31
KR20220087582A (ko) 2022-06-24
RU2014134555A (ru) 2016-03-20
AU2018201302A1 (en) 2018-03-15
JP2015508157A (ja) 2015-03-16
AU2016204178A1 (en) 2016-07-14
KR20190006598A (ko) 2019-01-18

Similar Documents

Publication Publication Date Title
KR102411809B1 (ko) 일주기 리듬 장애의 치료
JP6826216B2 (ja) 概日リズム障害の治療

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E601 Decision to refuse application
PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601

X091 Application refused [patent]
T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PX0901 Re-examination

St.27 status event code: A-2-3-E10-E12-rex-PX0901

PX0701 Decision of registration after re-examination

St.27 status event code: A-3-4-F10-F13-rex-PX0701

X701 Decision to grant (after re-examination)
A107 Divisional application of patent
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 5