KR102299932B1 - Cosmetic composition for blocking ultraviolet and generating hydrogen - Google Patents

Abstract

The present invention relates to a sunscreen cosmetic composition, and relates to a non-aqueous sunscreen cosmetic composition in which a powdered hydrogen generator and a sunscreen agent are dispersed in cosmetic oil or wax used as cosmetic raw materials, and the sunscreen cosmetic according to the present invention Even when UV protection is not complete, the composition has the effect of reducing intracellular active oxygen by hydrogen generated during use, preventing skin damage caused by UV rays, and inhibiting skin aging. It can exert the effect of reducing the expression of collagen degrading enzyme MMP-1 and inflammatory substances IL-6, IL-1β and COX-2, so it has the advantage of upgrading the performance of the UV-blocking cosmetic composition to the next level. In addition, since the powdered hydrogen generator is dispersed in cosmetic oil or wax that does not contain moisture, the problem of reacting in contact with moisture during storage or distribution has been solved. There are characteristics that can be exhibited together with the effect of

Description

Cosmetic composition for blocking ultraviolet and generating hydrogen

The present invention relates to a sunscreen cosmetic composition, and to a non-aqueous sunscreen cosmetic composition in which a powdered hydrogen generator and a sunscreen agent are dispersed in cosmetic oil or wax used as cosmetic raw materials.

Sunlight can be divided into infrared rays, visible rays and ultraviolet rays, and among them, it is widely known that ultraviolet rays can adversely affect the skin.

Ultraviolet rays can be classified into ultraviolet A (320 to 400 nm), ultraviolet B (290 to 320 nm), and ultraviolet C (200 to 290 nm) according to the length of the wavelength. UV C is reflected or scattered when it meets the ozone layer and is lost because it cannot reach the earth's surface.

UV B penetrates to the epidermis of the skin and can cause erythema, freckles, and edema. .

Recently, outdoor activities are increasing due to the expansion of leisure time and increased interest in health. In particular, as the dangers caused by exposure to sunlight are known, consumers' interest in sunscreen products is very high. Accordingly, products having various UV protection factors (Sun Protection Factor; SPF) and UV A blocking factors (Protection Factor in UVA; PFA) are being released.

UV protection products are broadly classified into water in oil (W/O), oil in water (O/W), or non-aqueous types according to the composition of their phases.

In the case of the water-in-oil type, it has excellent water resistance and durability, but has a disadvantage in that it has poor applicability and a heavy and stuffy skin feeling is not good due to the oily component of trauma. In the case of the water-in-water type, it has excellent spreadability, can be applied directly to the skin, and has the advantage of obtaining a fresh feeling of use given by external moisture, but lacks water resistance, so there is a limit to the durability of the effect due to sweat or water. In the case of the non-water type, it has the advantage of providing a unique feeling of use as well as the good water-resistance characteristic of the water-in-oil type.

Even though such various types of UV blocking cosmetics have been developed, there is a limit to effectively preventing skin damage and skin aging caused by UV rays.

1. Korean Patent Publication No. 10-2010-0028355 2. Korean Patent Publication No. 10-2014-0031503

Therefore, the problem to be solved by the present invention is to provide a sunscreen cosmetic composition of a new concept that can overcome the limitations of the sunscreen cosmetic composition.

In order to achieve the above technical problem, the present invention

powder hydrogen generator;

sunscreen;

It provides a sunscreen cosmetic composition comprising any one selected from the group consisting of cosmetic oils, cosmetic waxes, and mixtures thereof for dispersing the powder hydrogen generator and the sunscreen.

In the sunscreen cosmetic composition according to the present invention as described above, the sunscreen agent may be an inorganic sunscreen agent or an organic sunscreen agent, and the organic sunscreen agent is glyceryl faba, dromethrazole, digalloyl trioleate, 3-(4-methylbenzylidene)-camphor, methylanthranilate, diethylaminohydroxybenzoylhexylbenzoate, benzophenone-3, benzophenone-4, benzophenone-8, butylmethoxydibenzoylmethane, cinoxate , ethylhexyltriazone, octocrylene, octyldimethylfaba, ethylhexylmethoxycinnamate, ethylhexylsalicylate, paraaminobenzoic acid, 2-phenylbenzimidazole-5-sulfonic acid, homosalate, isoamyl -p-methoxycinnamate, bisethylhexyloxyphenol methoxyphenyltriazine, dromethrizole trisiloxane, and any one or more selected from the group consisting of polysilicon-15, the inorganic sunscreen is titanium dioxide, And it may be any one or more selected from the group consisting of zinc oxide.

In the sunscreen cosmetic composition according to the present invention as described above, the powder hydrogen generator includes magnesium hydride, calcium hydride, barium hydride, beryllium hydride, strontium hydride, lithium hydride, sodium hydride, sodium borohydride, sodium lithium hydride and It may be any one or more selected from the group consisting of silicon hydride.

In the sunscreen cosmetic composition according to the present invention as described above, the cosmetic oil may be a vegetable oil, and the vegetable oil may include olive oil, castor oil, avocado oil, almond oil, apricot seed oil, malt oil, evening primrose oil, It may be any one or more selected from the group consisting of jojoba oil, rosehip oil, palm oil and macadamia nut oil.

In the sunscreen cosmetic composition according to the present invention as described above, the cosmetic oil may be petrolatum.

In the sunscreen cosmetic composition according to the present invention as described above, the cosmetic wax is shea butter, cocoa butter, coconut oil, bayberry wax, candelilla wax, carnauba wax, castor wax, esparto wax And it may be any one or more selected from the group consisting of our curry wax.

As described above, the sunscreen cosmetic composition according to the present invention may further include an organic acid, and the preferred organic acid may be any one or more selected from the group consisting of citric acid, tartaric acid, malic acid, ascorbic acid and lactic acid.

The UV blocking cosmetic composition according to the present invention has the effect of reducing active oxygen in cells by hydrogen generated during use, preventing skin damage caused by UV rays, and inhibiting skin aging even when UV blocking is not complete. It can exert the effect of reducing the expression of MMP-1, a collagen-degrading enzyme, and IL-6, IL-1β, and COX-2, which are inflammatory substances, which are increased when irradiated with ultraviolet rays, so the performance of the UV-blocking cosmetic composition is upgraded to the next level. There are advantages to doing it.

In addition, since the powder hydrogen generator is dispersed in cosmetic oil or wax containing little moisture, the problem of reacting in contact with moisture during storage or distribution has been solved, and there is dispersion in oil or wax having a function as a cosmetic. There is a characteristic that can be exhibited together to the effect by these.

Hereinafter, specific contents for carrying out the invention will be described.

the present invention

powder hydrogen generator;

sunscreen;

It provides a sunscreen cosmetic composition comprising any one selected from the group consisting of cosmetic oil, cosmetic wax, and mixtures thereof for dispersing the powder hydrogen generator and the sunscreen.

The sunscreen in the present invention can be used without any particular limitation as long as it is used in the basic field of the field to which the present invention belongs.

Examples include inorganic sunscreens or organic sunscreens, and organic sunscreens include glyceryl fava, dromethrazole, digalloyltrioleate, 3-(4-methylbenzylidene)-campa, methylanthranilate. , diethylaminohydroxybenzoylhexylbenzoate, benzophenone-3, benzophenone-4, benzophenone-8, butylmethoxydibenzoylmethane, cinoxate, ethylhexyltriazone, octocrylene, octyldimethylpaba, E Chilhexylmethoxycinnamate, ethylhexylsalicylate, paraaminobenzoic acid, 2-phenylbenzimidazole-5-sulfonic acid, homosalate, isoamyl-p-methoxycinnamate, bisethylhexyloxyphenol methoxy At least one selected from the group consisting of phenyltriazine, dromethrizole trisiloxane, and polysilicon-15 is preferable, and the inorganic sunscreen is preferably at least one selected from the group consisting of titanium dioxide and zinc oxide .

In addition, the cosmetic composition according to the present invention includes a powdered hydrogen generator and cosmetic oil in which the powdered hydrogen generator and sunscreen are dispersed.

The present invention is to prepare a cosmetic composition using a compound that generates hydrogen by reaction with water, that is, a powdered hydrogen generator. Those which have a metal hydride compound, such as calcium, as a main component, etc. are known.

In the present invention, any compound known as a powder hydrogen generator can be used without any particular limitation, and a metal hydride compound is preferably used. In particular, magnesium hydride, calcium hydride, barium hydride, beryllium hydride, strontium hydride, lithium hydride, sodium hydride, It is to use any one or more selected from the group consisting of sodium borohydride, sodium lithium hydride and silicon hydride.

In addition. The cosmetic composition according to the present invention further comprises a cosmetic oil in which the powder hydrogen generator and the sunscreen powder are dispersed as described above.

The cosmetic oil used in the present invention can be used without any particular limitation as long as it is a cosmetic oil widely known in the art to which the present invention belongs, and examples thereof include vegetable oil, mineral oil (mineral oil), and animal oil.

Specifically, it is preferable to use vegetable oils that are non-irritating to the skin as components extracted from flowers, leaves, seeds, fruits, skins, and roots of plants. Among vegetable oils, olive oil, castor oil, avocado oil, almond oil, It is more preferable to use at least one selected from the group consisting of apricot seed oil, malt oil, evening primrose oil, jojoba oil, rosehip oil, palm oil and macadamia nut oil.

Olive oil is extracted from the olive fruit and is said to be soluble in ethanol. Most of the composition consists of oleic acid, which is effective in suppressing moisture evaporation and improving the feel.

Pimija oil is extracted from Pimija, a castor used as hair oil in Korea since ancient times. It has the property of mixing well with pigments, contains a lot of ricinol, and has high hydrophilicity and high viscosity.

Jojoba oil is an oil extracted from the jojoba tree, and its main component is an ester of high-grade unsaturated fatty acids. It has excellent skin adhesion and stability, so it is used in emulsion products and color cosmetics, which are basic cosmetics.

Avocado oil is an oil extracted from the fruit of avocado, and because it contains vitamins, it is particularly effective for dry skin. it is oil

Almond oil is sweet almond oil used in cosmetics, and it is used as an emollient in creams and lotions, as well as massage oil.

Apricot seed oil is extracted from apricot seeds and is used as an emollient because of its excellent texture.

Malt oil is extracted from wheat germ and is known to have antioxidant properties because it contains vitamin E. It helps blood circulation and is widely used in basic cosmetics, color cosmetics, and hair cosmetics.

Evening primrose oil is extracted from the seeds of evening primrose and contains abundant essential fatty acids. It has a healing effect on atopic dermatitis and is effective in inhibiting aging, moisturizing, and cell regeneration.

Rosehip oil is extracted from the ovary of wild roses and is known to be effective in wound healing. The main components are linolenic acid and ricinoleic acid.

Palm oil is extracted from palm seeds and contains a lot of triglycerides of low-fatty acids, so it is irritating to the skin.

Macadamia nut oil is extracted from the fruit of macadamia, and the fatty acid composition of triglycerides is similar to that of human sebum.

It is also preferable to use an animal oil such as mink oil or a mineral oil such as petrolatum.

In addition, as the cosmetic wax in the present invention is derived from a plant, it becomes a liquid state with increased fluidity when the temperature is applied after being solid at room temperature, so that the hydrogen storage metal can be dispersed. It can be used without any special restrictions.

The vegetable wax is selected from the group consisting of shea butter, cocoa butter, coconut oil, bayberry wax, candelilla wax, carnauba wax, castor wax, esparto wax, and our curry wax It is preferable to use it, and the most preferable is shea butter.

The shea butter is a vegetable oil extracted from the fruit of the shea tree, which has been used as a folk remedy in Africa for a long time. It is widely used as a moisturizer or emollient of The shea tree, called karite in French, grows in Africa, such as Mali, Cameroon, Congo, Ghana, Guinea, Senegal, Sudan, Nigeria, Burkina Faso, Uganda, and Cote d'Ivoire. Also known as Vitellaria paradoxa.

This kind of shea butter is yellow-green oil and has good flavor and flavor, so it is used for food in West Africa. In addition to moisturizing and regenerating the skin, shea butter is also known to have antioxidant and anti-inflammatory effects. Shea butter also has a UV protection effect, which is about 6 SPF (sun protection factor). In addition, it is used as a hair conditioner because it stimulates capillaries to make hair and scalp shiny, and to increase nutrition and regeneration power.

The cosmetic composition in which the powder hydrogen generator is dispersed in the cosmetic oil or wax as described above can be prepared by various methods, but for example, it can be directly dispersed in the cosmetic oil with fluidity, and the wax with weak circulation is It is prepared by dispersing the powdered hydrogen generator therein after increasing the fluidity by boiling water to make it liquid. However, the manufacturing method is not limited thereto.

And the amount of dispersing the powder hydrogen generator in cosmetic oil or wax is not particularly limited as it can be determined without particular difficulty by those of ordinary skill in the art in consideration of physical properties at the time of manufacture.

The cosmetic composition according to the present invention may further include any one or more selected from the group consisting of organic acids, preferably citric acid, tartaric acid, malic acid, ascorbic acid, and lactic acid, which can be used as cosmetics to promote hydrogen generation. In addition, in order to further enhance the skin protection effect from UV rays, it may further include a dry powder of copper saplings. it will be effective.

The above-mentioned Dongui herb is a dicotyledonous plant, Heteroptera, Heterenae, and its scientific name is Caltha. palustris var. membranacea It is also called Dongnamul or Ligeumhwa (立金花), and grows in wetlands. Leaves are clustered from white, thick roots. The leaves are heart-shaped or oval-shaped, and the length and width are 5-10 cm, respectively, and the edges have dull serrations or are flat. Flowers do not have petals and are fragments of sepals. It blooms in April-May, is yellow, hangs one or two at the end of a flower stalk, and has small flower branches. The fruit is a golden stone, hanging from 4 to 16 each, about 1cm long, with a style attached to the end. In the present invention, the above-ground parts except for the roots are used for such a grouse. It is safe to use with flowers during the flowering period.

The sunscreen cosmetic composition according to the present invention can be included without any particular limitation as long as it is an oil-friendly cosmetic ingredient, and even if it does not contain other ingredients, it contains cosmetic oil itself, so it can be used as an excellent sunscreen cosmetic by itself. And, if other oil-friendly functional ingredients are further included, a more excellent cosmetic composition can be obtained, that is, the cosmetic composition according to the present invention can faithfully serve as an oil-containing cosmetic base of the non-aqueous sunscreen cosmetic composition.

If the sunscreen cosmetic composition according to the present invention does not contain moisture, it can be used in basic cosmetics such as foundation and BB cream, and can also be used as a sunscreen absorbed in a puff, or a sunscreen produced in a stick form.

For example, by further including an amino acid-based gelling agent and a polyamide-based gelling agent that is a tertiary-amide-terminated polyamide copolymer (ATPA) gelling agent in the sunscreen cosmetic composition according to the present invention, it can be prepared in a stick form. .

When the UV-blocking cosmetic composition according to the present invention is applied, the powdered hydrogen generator reacts with naturally occurring sweat to generate hydrogen, and the generated hydrogen penetrates into the skin, thereby reducing intracellular active oxygen and damaging the skin by UV rays. It has the effect of preventing skin aging and reducing the expression of MMP-1, a collagen-degrading enzyme, and the inflammation-inducing substances, IL-6, IL-1β, and COX-2, which are increased when irradiated with UV rays. It compensates for the lack of UV protection.

As described above, hydrogen generation by sweat is also possible, and hydrogen can be generated by actively applying moisture to the area to which the sunscreen cosmetic according to the present invention is applied.

To further enhance the effect, it can be used to extend the skin contact time of hydrogen by covering it with a towel while hydrogen is being generated.

As described above, the UV-blocking cosmetic composition according to the present invention can reduce active oxygen in cells by hydrogen generated during use even when blocking UV rays is not complete, prevent skin damage caused by UV rays, and inhibit skin aging. In particular, it can exert the effect of reducing the expression of MMP-1, a collagen-degrading enzyme, and IL-6, IL-1β, and COX-2, which are inflammatory substances, which are increased when irradiated with ultraviolet rays It has the advantage of being able to upgrade the performance to the next level.

In addition, since the powdered hydrogen generator is dispersed in cosmetic oil or wax containing little moisture, the problem of reacting in contact with moisture during storage or distribution has been solved, and there is dispersion in oil or wax having a function as a cosmetic. There is a characteristic that can be exhibited together with the effect by these.

That is, the sunscreen cosmetic composition according to the present invention has a hydrogen generating function and can completely solve the problem of hydrogen generating cosmetics that may occur during distribution or storage exaggeration, thereby enabling the popularization of hydrogen cosmetics. Although it looks simple, it can be said to be a very innovative and progressive idea.

Hereinafter, the present invention will be described with reference to Examples and Experimental Examples. However, the scope of the present invention is not limited to these Examples and Experimental Examples.

< Example and comparative example Preparation of cosmetic composition>

To test the effect, cosmetic compositions were prepared as shown in Table 1. The numerical values in Table 1 below are weight %.

Comparative Example 1 Comparative Example 2 Example 1 Example 2 Example 3 Example 4 titanium dioxide 20 20 20 20 20 20 magnesium hydride 10 10 10 10 jojoba oil 80 70 60 shea butter 80 70 60 ascorbic acid 10 10

< Experimental example One : HaCaT cells Production of inflammatory cytokines using inhibitory effect>

The inhibitory effect on inflammatory cytokine production was measured using HaCaT cells. HaCaT cells were inoculated into a 96-well microplate ^{at a concentration of 1×10 4} cells/well, and cultured at 37° C., 5% CO _{2 in an} incubator for 24 hours.

The medium was removed and the cells were washed with phosphate buffered saline (PBS; Phophate Buffered Saline) as a washing buffer, and incubated for 24 hours in DMEM (Gibco) medium containing no serum added in Examples and Comparative Examples. After culturing, the medium was removed, and 100 μl of PBS was added to irradiate UV light, and then serum-free DMM medium was added again, followed by incubation at _{37° C., 5% CO 2 incubator.} As a control, only DMM medium containing no serum was added and irradiated with ultraviolet light.

UV irradiation was treated using VILBER LOURMAT to be 20 mJ/cm ² in which cells do not die with UV B.

The medium was collected by time period and analyzed for inflammatory cytokines. Inflammatory cytokines were quantified using Quantikine ELISA Human IL-1a and IL-23 (R&D Systems) for interleukin 1 alpha (IL-1a; Interleukin 1a) and interleukin 23 (IL-23; Interleukin-23), respectively. The inflammatory cytokine inhibition rate shows the inflammatory cytokine inhibition rate (%) results for each time period in Tables 2 and 3 below.

1 hour later after 3 hours after 6 hours after 9 hours Comparative Example 1 31.2 34.5 35.5 37.2 Comparative Example 2 31.3 34.1 35.4 37.2 Example 1 36.9 45.2 57.2 60.1 Example 2 36.7 45.6 56.9 60.2 Example 3 43.2 57.2 65.5 67.5 Example 4 43.9 57.8 65.1 67.5

1 hour later after 3 hours after 6 hours after 9 hours Comparative Example 1 31.5 35.2 35.7 38.0 Comparative Example 2 31.2 34.9 35.2 37.9 Example 1 35.2 46.1 57.1 61.2 Example 2 35.4 46.1 57.5 60.9 Example 3 43.5 57.5 64.8 68.2 Example 4 43.1 57.7 65.0 68.1

Referring to Tables 2 and 3, it was found that the composition according to the present invention was superior in inhibiting ability to inflammatory cytokines, which is a substance that causes aging by ultraviolet rays, compared to the composition of Comparative Example, and in particular, the composition containing ascorbic acid showed a more excellent effect. .

< Experimental example 3 human body skin whitening and Anti-inflammatory effect>

After attaching an opaque tape with 4 holes of 15 cm in diameter to the subject's upper forearm for 25 healthy men and women, and applying the compositions of Examples and Comparative Examples, the minimum erythema dose of each subject was 15 The ship was irradiated with ultraviolet rays (UVB) twice as much, and at the same time, water spray was sprayed so that hydrogen could be generated.

The degree of erythema and blackening of the skin induced by ultraviolet rays was measured using a colorimeter to measure the contrast of the skin.

The effect was determined by obtaining the “L” value representing the skin’s light and dark in the Chromameter CR300 (Minolta, Japan), and the “a” value representing the redness of the skin for the degree of erythema.

If the test substance is effective for whitening, the smaller the delta L(ΔL) value, which is the difference between the L value before the start of the test and the L value after the blackening is completely formed, if the test substance is effective for inflammation, before the start of the test a It is more effective as the delta a (Δa) value, which is the difference between the a value after the skin is reddened by the value and ultraviolet rays, and inflammation occurs. Changes in ΔL value and Δa value are shown in Tables 4 and 5 below. The comparative site|part was made into the site|part to which a sample was not apply|coated.

Whitening effect (△L) control 8.29 Comparative Example 1 4.27 Comparative Example 2 4.29 Example 1 2.12 Example 2 2.09 Example 3 1.14 Example 4 1.17

Inflammation inhibitory effect (Δa) control 7.09 Comparative Example 1 3.18 Comparative Example 2 3.21 Example 1 1.97 Example 2 1.89 Example 3 1.08 Example 4 1.07

As can be seen from Tables 4 and 5 above, the composition according to the present invention is excellent in the effect of preventing pigmentation caused by melanin, one of the aging phenomena caused by ultraviolet rays, and the effect of inhibiting inflammation caused by ultraviolet rays. can be checked

<add Example >

A cosmetic composition was prepared as shown in Table 6 in order to further test the effect of including the dry powder of the ginseng herb. The numerical values in Table 1 below are weight %.

Example 5 Example 6 titanium dioxide 20 20 magnesium hydride 10 10 jojoba oil 60 shea butter 60 dried herbs powder 10 10

For the compositions of Examples 5 and 6, the whitening and anti-inflammatory effects on the human skin of Experimental Example 3 were the same, and the results are shown in Tables 7 and 8. The results of 1 and 2 are presented together.

Whitening effect (△L) control 8.29 Comparative Example 1 4.27 Comparative Example 2 4.29 Example 1 2.12 Example 2 2.09 Example 5 1.08 Example 6 1.09

Inflammation inhibitory effect (Δa) control 7.09 Comparative Example 1 3.18 Comparative Example 2 3.21 Example 1 1.97 Example 2 1.89 Example 5 1.01 Example 6 1.02

As can be seen from Tables 7 and 8, the composition according to the present invention, including the dry powder of ginseng herbs, has the effect of preventing pigmentation by melanin, one of the aging phenomena caused by ultraviolet rays, and induced by ultraviolet rays. It was confirmed that the anti-inflammatory effect was excellent.

From the above experiment, the composition according to the present invention not only inhibits and improves skin aging by protecting the skin from UV rays, but also suppresses the inflammation caused by UV rays by inhibiting the expression of inflammatory cytokines, which are the root causes of skin aging due to UV rays. It was confirmed that the skin aging improvement effect was excellent by fundamentally preventing and improving skin aging.

Claims (11)

10 wt% of magnesium hydride as a powder hydrogen generator
20% by weight of titanium dioxide as a sunscreen;
10% by weight of the dried ginseng herb powder; and
A cosmetic composition containing 60% by weight of shea butter or jojoba oil as a cosmetic oil for dispersing the powdered hydrogen generator, sunblock, and dried copper ginseng powder.
The sunscreen cosmetic composition according to claim 1, wherein the composition further comprises an organic acid.
The sunscreen cosmetic composition according to claim 2, wherein the organic acid is at least one selected from the group consisting of citric acid, tartaric acid, malic acid, ascorbic acid, and lactic acid.

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