KR102265902B1 - Composition for relieving swelling, the spray dryer and the menufacturing method - Google Patents

Abstract

An object of the present invention is to obtain a composition having an excellent diuretic effect by increasing urine excretion and sodium excretion by using a herbal mixture with few side effects and a method for preparing the same. To achieve the above object, the method of the present invention comprises: an input step of inputting the raw material into an extractor (S10); an immersion step of extracting the raw material in the extractor at a temperature of 95 to 105°C for 7 to 9 hours, and then immersing the same again for 14 to 16 hours (S20); a first filtering step of filtering the immersed raw material in a filter of 140 to 160 mesh (S30); a concentration step of concentrating the filtered raw material to a solid content of 19 to 21 wt% (S40); a mixing step of mixing 34 to 36 wt% of dextrin with 64 to 66 wt% of the plant mixed concentrate, which is the concentrated raw material, to make a mixed solution (S50); a powder step of powdering the mixed solution using a spray dryer (100) (S60); and, a second filtering step of filtering the powder using a filter (S70). By the above configuration, the amount of urine excretion and the amount of sodium excretion are increased more, so as to provide an excellent diuretic effect and very effectiveness in alleviating swelling.

Description

A composition for improving swelling, a spray dryer used in the production of the composition, and a manufacturing method thereof {COMPOSITION FOR RELIEVING SWELLING, THE SPRAY DRYER AND THE MENUFACTURING METHOD}

The present invention relates to a composition for improving swelling, and in particular, for improving swelling containing an extract of a herbal mixture including jujube, ginger, dried pumpkin, rehmannia, angelica root, red bean, chrysanthemum, dermis, bamboo leaf, and seomoktae as an active ingredient It relates to a composition and a method for preparing the same.

Edema refers to a condition in which water and salt are excessively accumulated in the interstitium between cells due to an abnormality in the distribution of fluid due to abnormal water metabolism. It occurs mainly when there is a malfunction of the kidney or heart, or liver disease. It can also be caused by a lack of protein. can In other words, it is regarded as a disease that occurs when the three organs, the lung, spleen, and kidney, do not perform well.

In addition, the case of idiopathic edema for which a specific cause cannot be found is particularly common in women. This is because women who have a lot of negative energy compared to men do not have good circulation of qi and are often stagnant in one place. This is because the circulation of water in the body is also lowered and edema appears in many cases. This female edema is a symptom that accompanies the symptoms of general edema and gets worse before and after menstruation, ovulation, and before and after childbirth.

In particular, prenatal and postpartum edema (産前産下浮腫) is the swelling that occurs before and after childbirth in women, and refers to swelling of the body. The cause of prenatal and postpartum edema is caused by the accumulation of sodium in our body due to fatigue, stress, and the action of hormones before and after childbirth, or it worsens due to lack of exercise and poor blood circulation, making it worse in the uterus or perineum. Or it may appear as an inflammatory reaction at the cesarean section.

As a conventional technique for alleviating such swelling, there is "a method of manufacturing a composition for preventing and improving edema using pumpkin seeds, beets, maca and aronia and its composition" of Korean Patent Publication No. 10-2074192, but this There were some aspects that were not suitable for the constitution of Koreans because there were many non-Korean products, and there was a problem that it was not a material that could be easily collected from the surrounding area.

"Method for preventing and improving edema using pumpkin seeds, beets, maca and aronia, and composition thereof" in Korean Patent Publication No. 10-2074192

An object of the present invention is to obtain a composition having excellent diuretic effect and a method for preparing the same by increasing urine excretion and sodium excretion by using a herbal mixture with few side effects.

Another object of the present invention is to obtain a composition capable of very efficient drying by reducing internal pressure together with hot air when spray drying is performed, and a method for preparing the same.

The present invention, in order to achieve the above object, the input step of inputting the raw material to the extractor (S10); An immersion step (S20) of extracting the raw material in the extractor at a temperature of 95 to 105° C. for 7 to 9 hours, and then immersing it again for 14 to 16 hours; A first filtering step (S30) of filtering the immersed raw material in a filter of 140 to 160 mesh; a concentration step (S40) of concentrating the filtered raw material to a solid content of 19 to 21% by weight; A mixing step (S50) of mixing 34 to 36 wt% of dextrin with 64 to 66 wt% of the plant mixed concentrate, which is the concentrated raw material, to make a mixed solution (S50); A powder step (S60) of powdering the mixed solution using a spray dryer; And, a second filtering step (S70) of filtering the powder using a filter may be performed.

In particular, wherein the plant mixture concentrate, purified water 92.50 ~ 92.51% by weight; Jujube 2.36-2.37 wt%; Pumpkin 1.18 to 1.19 wt%; Ginger 0.78-0.79 wt%; Dolphin seeds 0.63 to 0.64% by weight; 0.55 to 0.56% by weight of Rehmannia root; and 0.39 to 0.40% by weight of each Angelica root, red bean, chrysanthemum, tangerine fruit peel, and bamboo leaf;

On the other hand, you may use eugeunpi instead of the root Angelica Root.

In addition, the spray dryer, the ceiling is provided with an atomizer for ejecting a liquid, a powder outlet is formed at the lowermost end, the airtight cylindrical drying chamber is located above the powder outlet and formed with a gas outlet through which the gas exits; And, by moving up and down in the drying chamber, the internal pressure is adjusted and the upper plate and the lower plate are formed. The upper plate is inclined to one side and is provided with one or more heat dissipation fins upward, and the lower plate is provided with an electrically connected heating wire. It is characterized in that it includes a piston;

Also, in the present invention, 34 to 36% by weight of dextrin is mixed with 64 to 66% by weight of a plant mixture concentrate having a solid content of 19 to 21% by weight; the plant mixture concentrate is purified water 92.50 to 92.51% by weight; Jujube 2.36-2.37 wt%; Pumpkin 1.18 to 1.19 wt%; Ginger 0.78-0.79 wt%; Dolphin seeds 0.63 to 0.64% by weight; 0.55 to 0.56% by weight of Rehmannia root; and 0.39 to 0.40% by weight of each Angelica root, red bean, chrysanthemum, tangerine fruit peel and bamboo leaf, respectively; is provided a composition for improving swelling, characterized in that it comprises.

Furthermore, you may use eugeunpi instead of the root of Angelica keiskei.

By the above configuration, the amount of urine excretion and the amount of sodium, etc. excreted more is increased, so that the diuretic effect is excellent, and thus it is very effective in improving swelling.

In addition, according to the powder dryer used in the manufacturing method of the present invention, there is an advantageous effect that a dried powder can be easily obtained by efficiently vaporizing by a piston without the need to separately inject hot air (H) from the outside.

1 is a flow chart for performing a method of manufacturing a composition for improving swelling of the present invention.
2 is a graph showing changes in body weight of experimental mice during an experiment using the composition for improving swelling of the present invention.
Figure 3 is a graph measuring the urine volume of experimental mice during the experiment using the composition for improving swelling of the present invention.
4(a) to 4(c) are graphs of Na, K, and Cl amounts, respectively, among the urine electrolyte test results of laboratory mice using the composition for improving swelling of the present invention.
5 is a conceptual diagram showing a conventional spray dryer.
6 is a perspective view showing a piston used in the method of manufacturing the composition for improving swelling of the present invention.
7 is a side view when the piston of the powder dryer used in the method for manufacturing the composition for improving swelling of the present invention is positioned at the top.
8 is a side view when the piston of the powder dryer used in the method for preparing the composition for improving swelling of the present invention is located in the middle.
9 is a side view when the piston of the powder dryer used in the method for preparing the composition for improving swelling of the present invention is located at the bottom.

The above objects, features and other advantages of the present invention will become more apparent by describing preferred embodiments of the present invention in detail with reference to the accompanying drawings. Hereinafter, with reference to the accompanying drawings, a composition for improving swelling and a method for manufacturing the same according to examples and experiments of the present invention will be described in detail.

1 is a flow chart for performing a method of manufacturing a composition for improving swelling of the present invention.

First, the input step (S10) of putting the raw material into the extractor proceeds.

The raw materials are purified water, jujube, pumpkin, ginger, stone bean seeds, rehmannia root, chrysanthemum root, red bean, chrysanthemum, mandarin orange peel and bamboo leaf. However, you can use yugunpi, which has excellent diuretic effect, instead of chamangwi root.

Next, in the extractor, the raw material is extracted at a temperature of 95 to 105° C. for 7 to 9 hours, followed by an immersion step (S20) of immersion for 14 to 16 hours again.

Next, a first filtering step (S30) of filtering the immersed raw material in a filter of 140 to 160 mesh is performed.

Next, a concentration step (S40) of concentrating the filtered raw material to a solid content of 19 to 21% by weight is performed.

Next, a mixing step (S50) of making a mixed solution by mixing 34 to 36% by weight of dextrin with 64 to 66% by weight of the plant mixture concentrate, which is the concentrated raw material, is performed.

Next, a powder step (S60) of powdering the mixed solution using a spray dryer and a second filtration step (S70) of filtering the powder using a filter are sequentially performed.

After that, it is better to set the packaging unit as needed and pack it.

In particular, the plant mixture concentrate here is purified water 92.50 ~ 92.51% by weight, jujube 2.36 ~ 2.37% by weight, pumpkin 1.18 ~ 1.19% by weight, ginger 0.78 ~ 0.79% by weight, stone bean seeds 0.63 ~ 0.64% by weight, rehufu It is good that the root is 0.55 to 0.56 wt%, and it is preferable that the Angelica root, red bean, chrysanthemum, mandarin orange peel, and bamboo leaf are each contained in an amount of 0.39 to 0.40 wt%.

<Experiment using laboratory mice>

This test was conducted to investigate the effect on diuresis when the composition for improving swelling of the present invention was orally administered to Sprague-Dawley (SD) male rats fed a high-salt diet. Test groups were set as normal control group (normal feed + sterile distilled water), negative control group (high salt diet + sterile distilled water) and test substance administration group (high salt diet + composition for improving swelling of the present invention 200 and 400 mg/kg/day) After that, the test substance was administered repeatedly for 16 days, and general symptoms, weight change, urine output, urine electrolytes, and blood electrolytes were examined during the experiment period.

1. Preparation of test substances

As for the preparation method, the test solution of the remaining dose group was prepared by weighing a fixed amount of the test substance on the day of administration, dissolving it in sterile distilled water to prepare a high-dose test solution, and then diluting it. Since it was administered immediately after preparation immediately before administration on the day of administration, a stability test was not performed.

The preparation frequency was prepared daily because the stability of the test solution was not secured.

2. test system

Male rats of Sprague-Dawley (SD) strain were used, and they were 7 weeks old at the time of acquisition, and the microbiological test report and appearance of the animals were examined on the day of acquisition. After acquisition, an acclimatization period of more than 7 days was provided, and only healthy animals were used for the test by observing general symptoms during the acclimatization period. At the time of testing, he was 8 weeks old. The body weight range at the time of acquisition was 184.49 ~ 204.57 g, and the weight range at the time of the test was 225.53 ~ 258.33 g. A total of 24 animals were used. The body weight was measured on the day before administration, and group separation was performed according to the ranked body weight. Only animals falling within the range of ±20% of the mean body weight were used for the test.

3. Animal room and breeding environment

The temperature of the animal room was 22±3 ℃, the relative humidity was 50±20%RH, the number of ventilation was 10 to 15 times/hr, and the light-dark cycle was 12 hr for fluorescent lighting (08:00 on to 20:00 off). . Illuminance was 150-300 Lux, noise was less than 60 db, and ammonia concentration was less than 15 ppm. In the breeding box and breeding density, no more than 3 animals were housed in a stainless steel mesh breeding box (250W×350L×180Hmm) during quarantine, acclimatization, administration and observation period. The breeding box was replaced during group separation. For feed and water (KCL/ANI/008, 015), standard diet (Teklad Certified Irradiated Global 18% Protein Rodent Diet, Envigo, USA) and high-salt diet (Teklad Custom Diet, 4% NaCl Diet, Envigo, USA) was put into a feeder and consumed freely, and water was purified by drinking tap water and then placed in a polycarbonate water bottle and consumed freely.

4. Test method

Oral administration, after correcting the skin of the head and neck of the test animal, it was forcibly administered orally using a sonde for oral administration. The frequency and time of administration were 1 time/day, 7 days/week, 16 days, and every morning in the morning, and the dose was calculated as 10 ml/kg/day based on the most recently measured body weight. For animal model induction, during the administration period after group separation, normal feed was given to the test animals of the normal control group, and a high-salt diet was fed to the test animals of the negative control group and the test substance-administered group.

[Table 1] shows the composition of the test group. G1 is a normal control group fed with general feed and sterilized distilled water, G2 is a negative control group fed with a high-salt diet and sterile distilled water, and G3~G4 is a test substance fed with a high-salt diet and the composition for improving swelling of the present invention. administration group.

5. Test items

General symptoms immediately after administration once a day were observed throughout the entire period of administration. For observation of general symptoms, death, type of symptom, onset date, and severity of symptoms were recorded for each individual.

Body weight was measured at the time of acquisition, at the time of group separation, at the start of administration, and once a week after administration for all animals.

For urinalysis, the test animals of all test groups were housed in metabolic cages before, during, and after administration, and fresh urine was collected and urinalysis was performed. Before administration, during administration, and at the end of administration, the test animals of all test groups were accommodated in metabolic cages and then urine output was measured for about 24 hours. For urine electrolytes, Na (Sodium, Sodium), K (Potassium, Potassium) and Cl (Chloride, Chloride) were measured using a blood biochemical tester (Hitachi 7180, HITACHI, Japan). In addition, the total urine electrolyte discharge was calculated by multiplying the measured urine amount and the urine electrolyte test value.

For blood biochemical tests, after completion of administration, all test animals were anesthetized by inhalation with Isoflurane. When anesthesia was confirmed, it was opened and blood was collected from the abdominal aorta, and then it was put into a serum separating tube (Sekisui, Insepack) and used for the test. Blood electrolyte test is a serum obtained by centrifugation (3,000 rpm, 10 minutes) of blood in a serum separating tube, using a blood biochemical tester (Hitachi7180, HITACHI, Japan) for Na (Sodium), K (Potassium) and Cl (Chloride). was measured.

6. Evaluation and Statistical Testing of Data

Trends were analyzed by organizing the mean and standard deviation, and the difference between the control group and the administration group was statistically tested using the Independent Samples t-Test and one-way ANOVA test. Duncan test was used if significance was recognized and equal variance was recognized in one-way ANOVA, and Dunnett's T3-test was used if equal variance was not recognized. When p<0.05, it was determined to be statistically significant, and statistical analysis was performed with the SPSS 12.0 K program (SPSS, Chicago, IL, U.S.A.), which is a commercially widely used statistical package.

7. Experimental results

[Table 2] shows general symptoms and mortality.

As can be seen from [Table 2], no dead animals or specific general symptoms were observed in all test groups during the experiment period.

2 is a graph showing the change in body weight of experimental mice during the experiment using the composition for improving swelling of the present invention, and [Table 3] is a table showing the change in body weight.

As can be seen from FIG. 2 and [Table 3], no statistically significant difference was observed between the test groups and the administration groups during the experimental period.

Figure 3 is a graph measuring the amount of urine in laboratory mice during the experiment using the composition for improving swelling of the present invention, [Table 4] is a table showing the amount of urine.

As can be seen from [Table 4] and FIG. 3, a statistically significant increase was observed in the negative control group compared to the normal control group on days 0, 7 and 15 during the experiment period. Specifically, it can be seen that compared with the value of the G1 group, the urine volume of the G2 group was significantly increased. On the other hand, a in [Table 4] indicates that one animal was excluded because it was thought that there was moisture that penetrated and acted on the urine.

4(a) to 4(c) are graphs measuring the amounts of Na, K, and Cl in the urine electrolyte test results of laboratory mice using the composition for improving swelling of the present invention, respectively, [Table 5] is Na, This is a table in which K and Cl amounts are measured.

As can be seen from FIGS. 4(a) to 4(c) and [Table 5], the Na(sodium) level of the negative control group on the 7th day was statistically significantly increased compared to the normal control group, and on the 7th and 15th days K ( potassium) was decreased.

In the 200 mg/kg/day test substance administration group, Na and Cl levels were significantly increased on days 7 and 15 compared to the negative control group.

[Table 6] is a table showing the total urine electrolyte discharge of experimental rats using the composition for improving swelling of the present invention.

As can be seen from [Table 6], the Na and Cl levels on days 0, 7, and 15 and K values on days 0 and 7 of the negative control group were statistically significantly increased compared to that of the normal control group. In the 200 mg/kg/day test substance administration group, Na and Cl levels were significantly increased on day 15 compared to the negative control group. On the other hand, a in [Table 6] indicates that one animal was excluded because it was thought that there was moisture that penetrated and acted on the urine.

[Table 7] is a table showing the blood electrolyte test results of laboratory mice using the composition for improving swelling of the present invention.

As can be seen from [Table 7], the Cl level of the 400 mg/kg/day test substance administration group increased statistically significantly compared to the negative control group.

8. Conclusion

In the urine electrolyte test, the 200 mg/kg/day test substance administration group increased Na and Cl levels on days 7 and 15 compared to the negative control group. Significance was not observed in the 400 mg/kg/day test substance administration group, and the values were lower than the 200 mg/kg/day administration group, but the Na and Cl levels were higher than that of the negative control group. A similar trend was observed in the total urine electrolyte discharge.

Therefore, the composition for improving swelling of the present invention, which is a test substance, increases urinary discharge of Na and Cl, and exhibits a higher discharge effect at a dose of 200 mg/kg/day. On the other hand, there is a report that urine volume, drinking water intake, and Na emission increase when a high concentration of Na is supplied to rats, so it is considered that the difference between the normal control group and the negative control group is due to the high-salt diet.

As a result of the blood electrolyte test, the Cl level of the 400 mg/kg/day test substance administration group increased, but it is considered to be a slight change in the level of the biological fluctuation range.

According to the above results, when the composition for improving swelling of the present invention was repeatedly orally administered to SD rats fed with a high-salt diet in this test condition, the diuretic effect of Na and Cl excretion was increased and higher than the 400 mg/kg/day dose. A higher excretion effect was exhibited at the 200 mg/kg/day dose.

In conclusion, it was found that the composition for improving swelling of the present invention was very effective in improving swelling due to its excellent diuretic effect by increasing urine excretion and sodium excretion more.

5 is a conceptual diagram showing a conventional spray dryer.

5 , in the conventional spray dryer 100 , when the liquid L to be dried is ejected through the atomizer 11 , hot air H is added to vaporize the moisture inside the drying chamber 10 . The vaporized gas G is discharged to the outside through the cyclone 15 and the blower 13, and the powder P is discharged downward.

6 is a perspective view showing a piston used in the method of manufacturing the composition for improving swelling of the present invention.

6, the piston 20 of the present invention adjusts internal pressure by moving up and down in the drying chamber 10 and is composed of an upper plate 21 and a lower plate 23, and the upper plate has an upper surface inclined to one side. One or more heat dissipation fins 25 are provided upwardly, and a heating wire 27 electrically connected to the inside of the lower plate is provided. Since it is a piston, it is obvious to those skilled in the art that it moves vertically in close contact with the inner circumferential surface of the drying chamber.

The reason the top plate is inclined to one side is to let the powder pour down to the inclined side by gravity. An electrically connected heating wire is wound a plurality of times inside the lower plate to heat the inside of the drying chamber, but one or more heat dissipation fins are provided on the upper surface of the upper plate to facilitate heat dissipation.

7 is a side view when the piston of the powder dryer used in the method for manufacturing the composition for improving swelling of the present invention is positioned at the top.

As can be seen from FIG. 7 , the spray dryer 100 of the present invention is provided with an atomizer for ejecting liquid on the ceiling, and a powder outlet 33 is formed at the lowermost end, and the gas is discharged while positioned above the powder outlet. The gas outlet 35 is formed in a closed cylindrical shape. Unlike the conventional spray dryer, hot air (H) does not flow in from the outside.

7 is a case in which the piston is positioned at the top, and when the liquid L is ejected, the temperature in the drying chamber rises only by heating of the heating wire. At this time, since the piston is higher than the gas outlet 35, the gas inside is not discharged to the outside.

8 is a side view when the piston of the powder dryer used in the method for preparing the composition for improving swelling of the present invention is located in the middle.

When the piston descends to lower the internal pressure, and at the same time, when the inside of the drying chamber 10 is heated by the heating wire, vaporization occurs actively. When it comes to the position in FIG. 8 , the vaporized gas escapes through the gas outlet 35 . However, in the position of Figure 8, the powder outlet 33 is not yet opened, so that the powder cannot escape.

9 is a side view when the piston of the powder dryer used in the method for preparing the composition for improving swelling of the present invention is located at the bottom.

When the piston is located at the lowermost end, the powder outlet 33 is opened and the powder is finally discharged to the outside.

Accordingly, according to the powder dryer used in the method for preparing the composition for improving swelling of the present invention, there is an advantageous effect that the dried powder can be easily obtained by efficiently vaporizing by the piston without the need to separately inject hot air (H) from the outside. .

As described above, various design changes may be attempted within the same scope as the subject of the present invention, but unless unexpected new effects appear in the present invention due to these design changes, the scope of the present invention cannot be departed from. will be.

S10: input stage
S20: immersion step
S30: first filtration step
S40: concentration step
S50: mixing step
S60: powder stage
S70: second filtration step
100: spray dryer
10: drying chamber
11: atomizer
20: piston
21: top plate
23: lower plate
25: heat sink fin
27: hot wire
33: powder outlet
35: gas outlet

Claims (3)

In the spray dryer 100 for powdering the mixed solution,
An atomizer 11 for ejecting the mixture is provided on the ceiling, and a powder outlet 33 is formed at the lowermost end, and a gas outlet 35 through which gas (G) exits while positioned above the powder outlet 33 A sealed drying chamber 10 of a cylindrical shape that is formed and does not introduce hot air (H) from the outside; and;
The internal pressure is adjusted by moving up and down in the drying chamber 10, and the upper plate 21 and the lower plate 23 are formed. It is provided, and the inner part of the lower plate 23 is a piston 20 provided with an electrically connected heating wire 27; including,
When the piston 20 is positioned at the top, the temperature in the drying chamber 10 rises only by heating the heating wire 27 and the piston 20 is higher than the gas outlet 35, so the gas inside is discharged to the outside. not released,
As the piston 20 descends from the top, the internal pressure is lowered and the inside of the drying chamber 10 is heated by the heating wire at the same time to cause vaporization, and a part of the gas outlet 35 is opened, but the powder outlet 33 is not opened. Until the vaporized gas escapes through the gas outlet 35, the powder does not escape to the outside,
When the piston 20 is located at the lowermost end, the powder outlet 33 is finally opened, and the powder is poured down to the side inclined to the side by gravity and discharged to the outside. spray dryer.
An input step (S10) of putting the raw material into the extractor;
An immersion step (S20) of extracting the raw material in the extractor at a temperature of 95 to 105° C. for 7 to 9 hours, and then immersing it again for 14 to 16 hours;
A first filtering step (S30) of filtering the immersed raw material in a filter of 140 to 160 mesh;
a concentration step (S40) of concentrating the filtered raw material to a solid content of 19 to 21% by weight;
A mixing step (S50) of mixing 34 to 36 wt% of dextrin with 64 to 66 wt% of the plant mixed concentrate, which is the concentrated raw material, to make a mixed solution (S50);
A powder step (S60) of powdering the mixed solution using the spray dryer 100 of claim 1; and;
A second filtration step (S70) of filtering the powder using a filter; but,
The plant mixture concentrate,
Purified water 92.50 ~ 92.51% by weight;
Jujube 2.36-2.37 wt%;
Pumpkin 1.18 to 1.19 wt%;
Ginger 0.78-0.79 wt%;
Dolphin seeds 0.63 to 0.64% by weight;
0.55 to 0.56% by weight of Rehmannia root; and;
Angelica root, red bean, chrysanthemum, tangerine fruit peel, and bamboo leaf are each 0.39-0.40% by weight;
The powder step (S60) is a step of ejecting the mixed solution mixed in the mixing step (S50) into the drying chamber 10 through the atomizer 11 provided in the drying chamber 10, the drying The internal pressure of the drying chamber 10 is adjusted by the piston 20 moving up and down inside the chamber 10 and the drying chamber 10 is heated. As the drying chamber 10 is heated, the mixture is mixed with powder. In the step of being classified as vaporized gas, the piston 20 descends so that a part of the gas outlet 35 is opened and the vaporized gas in the drying chamber 10 is discharged through the gas outlet 35 ) and the powder in the drying chamber 10 does not escape to the outside, and the piston 20 is located at the lowest end in the drying chamber 10 so that the powder outlet 33 is opened and Including the step of discharging the powder to the outside by
The step of heating the drying chamber 10 is heated by the heating wire 27 and the heat radiation fin 25 provided in the piston 20,
In the step of discharging the powder to the outside by gravity, the upper surface of the upper plate 21 of the piston 20 is inclined to one side, and the powder moves downward along the inclined upper surface by gravity. Method for producing a composition for improvement.
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