KR102240802B1 - 교차 결합 영역 배향을 갖는 이원 가변 영역 항체-유사 결합 단백질 - Google Patents

교차 결합 영역 배향을 갖는 이원 가변 영역 항체-유사 결합 단백질 Download PDF

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KR102240802B1
KR102240802B1 KR1020197012135A KR20197012135A KR102240802B1 KR 102240802 B1 KR102240802 B1 KR 102240802B1 KR 1020197012135 A KR1020197012135 A KR 1020197012135A KR 20197012135 A KR20197012135 A KR 20197012135A KR 102240802 B1 KR102240802 B1 KR 102240802B1
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val
thr
leu
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KR1020197012135A
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KR20190049902A (ko
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니콜라스 보렝
크리스티안 바일
카르슈텐 코르바이
크리스티안 랑게
단시 리
벵상 미콜
앙케 슈타인메츠
에르콜레 라오
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사노피
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65657124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR102240802(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 사노피 filed Critical 사노피
Priority to KR1020217010506A priority Critical patent/KR102607708B1/ko
Priority claimed from PCT/US2012/030948 external-priority patent/WO2012135345A1/en
Publication of KR20190049902A publication Critical patent/KR20190049902A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
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    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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KR1020197012135A 2011-03-28 2012-03-28 교차 결합 영역 배향을 갖는 이원 가변 영역 항체-유사 결합 단백질 KR102240802B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217010506A KR102607708B1 (ko) 2011-03-28 2012-03-28 교차 결합 영역 배향을 갖는 이원 가변 영역 항체-유사 결합 단백질

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161468276P 2011-03-28 2011-03-28
US61/468,276 2011-03-28
FR1160311 2011-11-14
FR1160311 2011-11-14
PCT/US2012/030948 WO2012135345A1 (en) 2011-03-28 2012-03-28 Dual variable region antibody-like binding proteins having cross-over binding region orientation

Related Parent Applications (1)

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KR1020137028279A Division KR101974901B1 (ko) 2011-03-28 2012-03-28 교차 결합 영역 배향을 갖는 이원 가변 영역 항체-유사 결합 단백질

Related Child Applications (1)

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KR1020217010506A Division KR102607708B1 (ko) 2011-03-28 2012-03-28 교차 결합 영역 배향을 갖는 이원 가변 영역 항체-유사 결합 단백질

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KR20190049902A KR20190049902A (ko) 2019-05-09
KR102240802B1 true KR102240802B1 (ko) 2021-04-16

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KR1020197012135A KR102240802B1 (ko) 2011-03-28 2012-03-28 교차 결합 영역 배향을 갖는 이원 가변 영역 항체-유사 결합 단백질

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KR (1) KR102240802B1 (hu)
CL (1) CL2013002763A1 (hu)
ES (1) ES2859906T3 (hu)
HR (1) HRP20210240T1 (hu)
HU (1) HUE053139T2 (hu)
IL (3) IL249369B (hu)
LT (1) LT3199547T (hu)
MX (2) MX366923B (hu)
PH (1) PH12018501305A1 (hu)
PT (1) PT3199547T (hu)
RU (1) RU2019122155A (hu)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5989830A (en) 1995-10-16 1999-11-23 Unilever Patent Holdings Bv Bifunctional or bivalent antibody fragment analogue
WO2009052081A2 (en) 2007-10-15 2009-04-23 Sanofi-Aventis Antibodies that bind il-4 and/or il-13 and their uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2158221T3 (pl) * 2007-06-21 2019-02-28 Macrogenics, Inc. Kowalencyjne diaciała i ich zastosowania
TW201109438A (en) * 2009-07-29 2011-03-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5989830A (en) 1995-10-16 1999-11-23 Unilever Patent Holdings Bv Bifunctional or bivalent antibody fragment analogue
WO2009052081A2 (en) 2007-10-15 2009-04-23 Sanofi-Aventis Antibodies that bind il-4 and/or il-13 and their uses

Also Published As

Publication number Publication date
LT3199547T (lt) 2021-02-25
MX2019009016A (es) 2019-09-10
HRP20210240T1 (hr) 2021-04-02
PH12018501305A1 (en) 2020-01-27
MX366923B (es) 2019-07-31
IL274870B2 (en) 2023-05-01
KR20190049902A (ko) 2019-05-09
IL274870B1 (en) 2023-01-01
HUE053139T2 (hu) 2021-06-28
IL249369B (en) 2019-11-28
IL274870A (en) 2020-07-30
CL2013002763A1 (es) 2014-03-07
PT3199547T (pt) 2021-02-02
RU2019122155A (ru) 2020-03-16
IL249369A0 (en) 2017-02-28
IL274876A (en) 2020-07-30
ES2859906T3 (es) 2021-10-04

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