KR102222731B1 - 분석물 검출을 위한 범용 바이오센서 시스템 - Google Patents
분석물 검출을 위한 범용 바이오센서 시스템 Download PDFInfo
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- KR102222731B1 KR102222731B1 KR1020197021112A KR20197021112A KR102222731B1 KR 102222731 B1 KR102222731 B1 KR 102222731B1 KR 1020197021112 A KR1020197021112 A KR 1020197021112A KR 20197021112 A KR20197021112 A KR 20197021112A KR 102222731 B1 KR102222731 B1 KR 102222731B1
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| US8216797B2 (en) * | 2001-02-07 | 2012-07-10 | Massachusetts Institute Of Technology | Pathogen detection biosensor |
| US7223550B2 (en) * | 2001-02-08 | 2007-05-29 | Temple University-Of The Commonwealth System Of Higher Education | Biosensor for defecting chemical agents |
| WO2003027680A2 (en) * | 2001-09-28 | 2003-04-03 | Silver Robert B | Makrophage-based biosensor for detection of toxic substances |
| EP2017618A1 (en) * | 2007-07-20 | 2009-01-21 | Koninklijke Philips Electronics N.V. | Methods and systems for detecting |
| US9023640B2 (en) * | 2011-12-13 | 2015-05-05 | Fundamental Solutions Corporation | Device for rapid detection of infectious agents |
| WO2014160140A1 (en) * | 2013-03-13 | 2014-10-02 | Applied Biomolecular Technologies | System for rapidly detecting infectious agents using a hybridoma-based biosensor |
| KR20170127015A (ko) * | 2015-03-13 | 2017-11-20 | 유니버시티 오브 매릴랜드, 발티모어 | 만능항체 매개 바이오센서 |
| CN107429286A (zh) * | 2015-03-31 | 2017-12-01 | 基本解决方案公司 | 用于快速检测分析物的生物传感器系统 |
| US9752199B2 (en) | 2015-03-31 | 2017-09-05 | Fundamental Solutions Corporation | Biosensor system for the rapid detection of analytes |
-
2017
- 2017-12-21 WO PCT/US2017/067787 patent/WO2018119173A1/en not_active Ceased
- 2017-12-21 IL IL267568A patent/IL267568B2/en unknown
- 2017-12-21 CA CA3046623A patent/CA3046623C/en active Active
- 2017-12-21 EP EP17838104.2A patent/EP3559278B1/en active Active
- 2017-12-21 JP JP2019534878A patent/JP2020507060A/ja active Pending
- 2017-12-21 RU RU2019119811A patent/RU2737943C1/ru active
- 2017-12-21 KR KR1020197021112A patent/KR102222731B1/ko active Active
- 2017-12-21 CN CN201780086494.1A patent/CN110300807A/zh active Pending
-
2022
- 2022-12-07 JP JP2022195499A patent/JP2023059269A/ja active Pending
-
2025
- 2025-01-31 JP JP2025014424A patent/JP2025072435A/ja active Pending
Non-Patent Citations (3)
| Title |
|---|
| CHOQUET, D. et al., J. Biol. Chem., 1994년, Vol. 269, pp.6491-6497 |
| CURTIS, T. et al., Biosens. Bioelectron., 2008년, Vol.23, pp.1024-1031 |
| RIDER, T. H. et al., Science, 2003년, Vol. 301, pp. 213-215. |
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| Publication number | Publication date |
|---|---|
| KR20190099264A (ko) | 2019-08-26 |
| EP3559278B1 (en) | 2024-08-14 |
| WO2018119173A1 (en) | 2018-06-28 |
| JP2023059269A (ja) | 2023-04-26 |
| RU2737943C1 (ru) | 2020-12-07 |
| CN110300807A (zh) | 2019-10-01 |
| EP3559278A1 (en) | 2019-10-30 |
| IL267568B (en) | 2022-12-01 |
| CA3046623A1 (en) | 2018-06-28 |
| JP2020507060A (ja) | 2020-03-05 |
| IL267568B2 (en) | 2023-04-01 |
| IL267568A (en) | 2019-08-29 |
| CA3046623C (en) | 2022-05-17 |
| JP2025072435A (ja) | 2025-05-09 |
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