KR102222588B1 - Led patch combination fusion stent - Google Patents

Abstract

The present invention relates to an LED patch combination-type fusion stent which is inserted into the duodenum for treating diabetes or fatty liver. More specifically, the present invention relates to an LED patch combination-type fusion stent composed of: a duodenal implantable stent structure with a mesh structure; and a unit for phototherapy in which an LED patch having a light source module for irradiating light toward the mucous membrane of the duodenum and a battery stacked while being superimposed on the LED patch are combined, wherein one or more units for phototherapy are arranged inside and outside the stent structure and are connected to each other.

Description

LED patch combination type fusion stent {LED PATCH COMBINATION FUSION STENT}

The present invention relates to an LED patch-coupled fusion stent, and more particularly, to an LED patch-coupled fusion stent inserted into the duodenum for treatment of diabetes or fatty liver.

A stent is when the flow of blood or body fluids such as blood vessels, gastrointestinal tract, biliary tract, etc. is not smooth due to malignant or benign disease. It is a cylindrical medical material used to normalize.

The advantage of an interventional procedure using a stent is that it is more convenient than a surgical method, can reduce the burden caused by general anesthesia, and has a high success rate, which is widely used worldwide.

The types of stents include balloon expansion using balloons and self-inflating stents using shape memory alloys depending on the mechanism of action to secure the lumen, and are selectively used depending on the organ and disease in which the stent is installed. The self-expanding stent is made of stainless steel and nitinol, a shape-memory alloy.

On the other hand, in the case of obese patients, fatty liver or diabetes, which is one of the metabolic syndromes, may accompany obesity, so there is a need for a method for simultaneously expecting treatment of obesity and fatty liver or diabetes. However, it is known that the duodenal mucosa plays an important role in the occurrence of obesity and diabetes.

Accordingly, there is a technique for resurfacing the duodenal mucosa using an endoscope called DMR (duodenal mucosal resurfacing) to induce metabolic improvement in the duodenal mucosa, but the technique is a method of heating the duodenal mucosa by applying a hydrothermal method with hot water. Therefore, in the DMR method, the duodenal mucosa is heated at a temperature of 80 degrees for about 5 minutes, so that the duodenal mucosa is burned, and complications, pain, and narrowing may occur.

In other words, in the case of obese patients, the nutrient components of ingested food are partially restricted from being normally absorbed by the human body from the small intestine, such as the duodenum, and the pathological cells of the duodenal mucosa are killed by the expansion of the stent, and the duodenal mucosa regeneration effect according to the ischemic change. , There is a need for a stent that can help the treatment of obesity and fatty liver and diabetic patients.

Korean Registered Patent Publication No. 10-1704769 (2017.02.08)

The present invention was derived to solve the problems of the prior art described above, the object of the present invention is to mount an ultra-small LED device as a light source of the size of a hair on a flexible substrate for treatment of diabetes or fatty liver, and combine it with a flexible thin film type battery It is intended to provide an LED patch-coupled fusion stent that emits light to the duodenal mucosa by stacking and arranging one or more light therapy units on a stent structure.

In addition, another object of the present invention is an LED patch-coupled type that can control to turn on/off the light source module of the phototherapy unit using an application installed in a wirelessly connected smart phone or an external communication device corresponding thereto. It is intended to provide a fusion stent.

In addition, another object of the present invention is to provide a structure in which light source modules of a light therapy unit arranged in a stent structure are spaced apart from each other at a predetermined interval.

The LED patch-coupled fusion stent according to an aspect of the present invention for solving the above technical problem includes a duodenal insertion-type stent structure having a mesh structure and a light source module for irradiating light toward the mucous membrane of the duodenum. It consists of a light therapy unit consisting of a combination of one LED patch and a battery stacked while being superimposed on the LED patch, and the light therapy unit is arranged in one or more inner and outer sides of the stent structure and connected to each other. There is this.

In addition, the LED patch of the present invention maintains at least one light source module forming an array of LEDs for emitting light to a flexible circuit board having a predetermined elongation, a power connection terminal connected to the battery, and a constant voltage. It is characterized by including a regulator circuit for supplying, a booster circuit for boosting a predetermined voltage supplied from a battery, and a driving driver for controlling the operation of the light source module.

In addition, any one of the LED patches of the present invention further comprises a Bluetooth circuit including a Bluetooth chip and a Bluetooth antenna, and is controlled using an application installed in a smartphone having a Bluetooth function or an external communication device corresponding thereto. There is this.

In addition, the antenna of the present invention is characterized in that it is inserted into the thickness of the circuit board to be embedded.

In addition, the phototherapy unit of the present invention is arranged in a row by connecting a certain number at a predetermined interval at a position divided by 120 degrees along the outer peripheral surface of the stent structure, and the outer peripheral surface of the stent structure inner side. It is characterized in that a predetermined number is connected and arranged in a line with a predetermined interval at each position separated by a 120 degree angle so as to deviate from the arrangement of the light treatment units arranged on the outer circumferential surface, so that the light source modules are spaced apart from each other at the same interval.

In addition, the optical therapy unit of the present invention is provided with a link line for connecting each of the link lines to each other, and the link line stretches and stretches when the stent structure is contracted, and when the stent structure is contracted, it is stretched to return to its original state. ) Is designed in the form of a characteristic.

In addition, the link line of the present invention is characterized by a dual structure including a signal line for connecting the LED patch included in the phototherapy unit and a power line for connecting power sources of the battery.

In addition, by allowing the on/off control signal of the light source module to be transmitted to another LED patch through the signal line of the present invention, it is possible to perform on/off of the light source module of the LED patch connected as a whole. There are features that make it possible.

In addition, the batteries are connected to each other through the power line of the present invention, so that the connected batteries can be driven in either series or parallel.

In addition, the stent structure of the present invention is characterized in forming a rhombus-shaped mesh structure by connecting a single strand of wire made of an expandable alloy, or intersecting or intersecting a plurality of wires.

In addition, the phototherapy units stacked and arranged in and out of the stent structure of the present invention are protected by forming a film through an encapsulation process wrapped with transparent flexible silicone.

The present invention using the aforementioned LED patch-coupled fusion stent can provide an effect of eliminating pathological cells in the mucous layer, inducing metabolic improvement through normal mucosal regeneration, and minimizing duodenal stenosis using low energy (LTT, low-temperature ablation) of the LED. have.

In addition, the LED patch-coupled fusion stent according to the present invention has no complications, can be performed multiple times, and provides an effect of treating the accompanying fatty liver without the need for taking diabetes drugs for several months or more with a single procedure.

In addition, the LED patch-coupled fusion stent according to the present invention has the effect of being able to use safely and conveniently by integrating the light therapy unit through a process of encapsulating (Encapsulation) a transparent flexible silicone.

In addition, the LED patch-coupled fusion stent according to the present invention is controlled to turn on/off the light source module of the phototherapy unit using an application installed in a wirelessly connected smartphone or an external communication device corresponding thereto. , There is an effect that can minimize the induction of pain through light irradiation.

1 is a perspective view showing the appearance of an LED patch-coupled fusion stent according to an embodiment of the present invention,
2 is a front view before and after contraction of the LED patch-coupled fusion stent according to an embodiment of the present invention,
3 is a cross-sectional view of an LED patch-coupled fusion stent according to an embodiment of the present invention before and after contraction.
4 is a block diagram showing the configuration of an LED patch according to an embodiment of the present invention,
5 is a block diagram showing the configuration of a first patch, which is one of the LED patches according to an embodiment of the present invention.
6 is an exemplary view showing states before and after contraction of a link line for connection of a phototherapy unit according to an exemplary embodiment of the present invention.
7 is an exemplary view of an LED patch-coupled fusion stent coated with a flexible silicone capsule according to the present invention,
8 is an exemplary view of the operation of the LED patch-coupled fusion stent according to the present invention.
9 is a graph made by experimenting with an LED patch-coupled fusion stent according to the present invention in a diabetic animal model.

The terms or words used in the specification and claims should not be construed as being limited to their usual or dictionary meanings, and the inventor may appropriately define the concept of terms in order to describe his own invention in the best way. It should be interpreted as a meaning and concept consistent with the technical idea of the present invention based on the principle that there is.

Therefore, the embodiments described in the present specification and the configurations shown in the drawings are only the most preferred embodiment of the present invention, and do not represent all the technical spirit of the present invention, and thus various equivalents that can replace them at the time of application It should be understood that there may be water and variations.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1 is a perspective view showing the appearance of the LED patch-coupled fusion stent according to the present invention, Figure 2 is a front view before and after contraction of the LED patch-coupled fusion stent according to the present invention, Figure 3 is according to the present invention A cross-sectional view of the LED patch-coupled fusion stent before and after contraction.

As shown in the drawings, the LED patch-coupled fusion stent 10 of the present invention includes an implantable stent structure 100 having a mesh structure and a light source module for irradiating light to the stent structure 100 ( It comprises a light therapy unit 200 made by combining an LED patch 210 having 211) and a battery 220 that is stacked while being superimposed on the LED patch 210.

The stent structure 100 of the present invention forms a wire mesh structure made of a rhombus by connecting one strand of wire or woven or crossing a plurality of strands of wire.

The stent structure 100 is an expandable alloy structure in which a nanostructure is effectively formed on a surface, and a material of nitinol, which is a shape memory alloy whose shape changes according to the temperature in the body, may be used, but is not limited thereto.

In this case, the stent structure 100 may be in close contact with the duodenal inner wall while maintaining the curved shape of the duodenal inner wall by applying a coupling structure that has different expansion forces for each portion according to the curved structure of the duodenum.

As shown in FIG. 2, the stent structure 100 to which the phototherapy unit 200 is coupled has an outer diameter of about 2 to 3cm before contraction, and when contracting while stretching while holding both ends for a procedure, a mesh in the form of a rhombus As the net stretches, the outer diameter decreases, and the outer diameter is maintained at around 1cm when contracted.

Accordingly, when the stent structure 100 to which the light therapy unit 200 is coupled is inserted into the curved structure of the duodenum, it expands and expands while being in close contact with the inner wall of the duodenum.

The phototherapy unit 200 is arranged to be connected to each other in a predetermined arrangement on the inside and outside of the stent structure 100, and a predetermined interval in a row for each position divided by 120 degrees along the outer circumferential surface of the stent structure 100 The stent structure 100 is connected and arranged, and is arranged in a line at a position separated by a 120 degree angle along the outer circumferential surface of the stent structure 100 at a predetermined interval.

Accordingly, as an embodiment of the present invention, the light treatment unit 200 includes four light treatment units 200 at regular intervals at every three lines of points divided by 120 degrees to the outer outer circumferential surface of the stent structure 100. The phototherapy units are spaced apart and arranged in a line, and are separated from the arrangement of the phototherapy units 200 disposed on the outer outer circumferential surface of the stent structure 100 at a 120-degree angle so as to deviate from each other. (200) It is formed so that three are spaced at regular intervals and arranged in a line.

Therefore, in the phototherapy unit 200 according to an embodiment of the present invention, 12 phototherapy units 200 are arranged at regular intervals in the form of 3x4 on the outer outer circumferential surface of the stent structure 100, and the stent structure 100 The inner and outer circumferential surfaces of the 9 light therapy units 200 are arranged at regular intervals in the form of 3x3.

At this time, since the direction in which the light source of the phototherapy unit 200 is irradiated should be directed toward the duodenal mucosa, the battery part of the phototherapy unit 200 is attached to the stent structure 100 on the outer circumferential surface of the stent structure 100. It may have a form to be attached, and the LED patch portion of the light therapy unit 200 is attached and bonded from the inside of the stent structure 100 on the inner outer circumferential surface of the stent structure 100, so that the battery portion of the stent structure 100 It can be seen that it is made in the direction of the inner through hole.

Therefore, as in the cross-sectional structure of the LED patch-coupled fusion stent of FIG. 3 before contraction, it has three lines on the outer outer circumferential surface of the stent structure 100, and is spaced apart by three lines from the inner outer circumferential surface of the stent structure 100. When the formed phototherapy unit 200 is contracted while holding both ends for a procedure, the phototherapy unit 200 disposed outside and inside the stent structure 100 is flexible. As it narrows, it forms a constricted structure.

4 is a block diagram showing the configuration of an LED patch according to the present invention, and FIG. 5 is a block diagram showing the configuration of a first patch, which is one of the LED patches according to the present invention.

As shown in FIG. 4, the LED patch 210 in the light therapy unit 200 of the present invention is one or more light sources mounted to emit light on a flexible circuit board in order to function as an optical unit for photodynamic therapy. A module 211, a power connection terminal 212 connected to the battery, a regulator circuit 213 for maintaining and supplying a constant voltage to each component, and a booster circuit 214 for boosting a constant voltage supplied from the battery. Can include. In addition, it may include a driving driver 215 for controlling the operation of the light source module.

The circuit board uses a flexible printed circuit board (FPCB) as an elastic material having a predetermined elongation. For example, the circuit board may be an FPCB having a thickness of about 0.1 to 0.2 mm.

Accordingly, the LED patch 210 may have a stretchable patch structure capable of maintaining a stable power supply and a bonding state of a circuit configuration even if the shape is varied, and thus may be freely bent or stretched.

The light source module 211 is formed in a form in which a light emitting diode (LED) emitting light is mounted as a plurality of arrays. As an embodiment, an LED may be mounted in the form of an array that is formed in 4 horizontally and 5 vertically.

The LED of the present invention may have a rated voltage of 2V, and the brightness of the illumination is uniform, and a micro LED having a size of 100 to 300 micrometers (um) may be used.

The light source modules 211 in the form of an array are formed at three points positioned at equal intervals in one LED patch. That is, three light source modules 211 may be arranged at equal intervals in one LED patch.

Therefore, in the LED patch-coupled fusion stent of the present invention, the light source by the three light source modules 211 can be emitted on one light treatment unit 200, and the light treatment unit 200 is connected and arranged. To the outside of the stent structure 100, 36 light sources can be irradiated by an arrangement of 3x4x3, and 27 light sources of 3x3x3 can be irradiated to the inside, so that as a whole, 63 light sources can be irradiated evenly at equal intervals. It is structured to be able to.

As shown in Figure 5, any one of the LED patches of the present invention includes a Bluetooth chip capable of BLE (Bluetooth Low Energy) communication so as to be controlled using an application installed in a smartphone having a Bluetooth function or an external communication device corresponding thereto. A Bluetooth circuit 226 may be further included.

The LED patch including the Bluetooth circuit may be referred to as a first patch.

Therefore, a Bluetooth antenna circuit 227 for Bluetooth communication needs to be designed in the first patch. In this case, the antenna 227 of the present invention may be designed and built in a form that is inserted into and built into a substrate of a circuit board.

The antenna for Bluetooth communication may be an antenna in the 2.4 GHz Industry-Science-Medical (ISM) band, and the Bluetooth antenna to which this ISM band is applied has a certain thickness.In the present invention, the thickness of such an antenna is minimized. This is to do.

For example, when a general Bluetooth antenna has a thickness of 2mm, the thickness of the LED patch can be further reduced by inserting and embedding it so as to overlap the thickness of the circuit board.

Since the Bluetooth circuit 226 and the built-in antenna 227 are designed and made in an extra space of the first patch, the size of each LED patch is the same.

Accordingly, the first patch may receive an on/off control signal for the light source module 211 transmitted from a smart phone or an external communication device corresponding thereto through Bluetooth communication, and the first patch The light source module 221 of the light therapy unit 200 connected through the provided driving driver 225 is controlled to be turned on/off.

At this time, another second patch having the same configuration as the first patch may be further configured, and the unit of the number of LED patches connected to the first patch and the second patch is divided and connected to the first patch and the second patch. By performing the divisional control of the light source module, it may be implemented to minimize the incidence of pain through partial light irradiation.

6 is an exemplary view showing states before and after contraction of a link line for connection of a phototherapy unit according to an embodiment of the present invention, and shows a stent state in a normal state and a stent state after contraction.

As shown in FIG. 6, when the phototherapy unit 200 of the present invention is arranged to be outside and inside the stent structure 100, a link line 230 for connecting each of the phototherapy units 200 to each other It is made up.

The link line 230 is a signal line for connecting the LED patch 210 included in the light therapy unit 200 and a power source for connecting the power of the battery 220 included in the light therapy unit 200 It has a redundant structure including lines. In addition, the link line 230 may function as a support line as a mechanical connection for maintaining a predetermined distance between the optical therapy units 200 arranged when the stent structure 100 is contracted/expanded.

Therefore, the link line 230 is designed in a shape that can be freely bent like a wave in order to have a stretchable structure when the stent structure 100 is contracted/expanded.

Accordingly, when the stent structure 100 is contracted, the link line 230 is stretched and stretched, and when the stent structure 100 is expanded, it may be brought back to its original state.

In addition, since each of the LED patches 210 are connected to each other through a signal line included in the link line 230, an on/off control signal of the light source module 211 by the first patch is different. By being transmitted to the LED patch 210, it is possible to perform on/off of the light source module 211 of the LED patch 210 connected as a whole.

In addition, since the batteries 220 are connected to each other through a power line included in the link line 230, the batteries 220 can be connected to be driven in series or in parallel, so that battery power can be more usefully utilized. .

In addition, the light therapy unit 200 is formed by combining a battery 220 that is stacked while overlapping the same area as the LED patch on the opposite side of the surface from which light is emitted from the light source module 211 of the LED patch 210.

The battery 220 may be referred to as a thin film battery that can be applied to a curved surface having a curvature of a predetermined radius by having a flexible characteristic. For example, the battery may be a thin film type battery having a thickness of 0.3 to 0.4 mm.

At this time, the battery 220 may be a single thin-film battery stacked in one shape on the LED patch, and also, a battery in the form of an array of small thin-film cells having a certain number horizontally and vertically (array) ( 220) may be stacked on the LED patch 210.

7 is an exemplary view of an LED patch-coupled fusion stent coated with a flexible silicone capsule according to the present invention.

That is, the phototherapy unit 200 that is stacked and arranged in and out of the stent structure 100 described above is integrated by forming a film through an encapsulation process that is wrapped with transparent flexible silicone that is harmless to the human body.

Accordingly, the present invention smoothly irradiates the light source of the light source module arranged at regular intervals in a transparent state to the mucous membrane of the duodenum due to the film coated with transparent silicone formed outside the phototherapy unit 200 as shown in FIG. 8. In addition, while protecting the phototherapy unit 200, it can be driven while minimizing a contact effect on a human body due to an electrical operation.

8 is an exemplary view of the procedure of the LED patch-coupled fusion stent according to the present invention.

As the light source is irradiated toward the mucous membrane of the inner wall of the duodenum by the LED patch-coupled fusion stent 10, which was performed as shown in the figure, the pathologic cell disappearance of the mucous layer, metabolism improvement through normal mucosa regeneration, and low energy of the LED ( LTA, low-temperature ablation) can have the effect of minimizing duodenal stenosis.

In the case of irradiating the pancreas with light for 22 seconds using the low energy of LED, for example, with an output of 40mW/cm2 per unit area (cm2), it improves pancreas regeneration and liver glucose synthesis and carbohydrate metabolism in a diabetic animal model. It was confirmed through an experiment that it has a blood sugar lowering effect.

9 is a graph made by experimenting with an LED patch-coupled fusion stent according to the present invention in a diabetic animal model.

As described above, in the detailed description of the present invention, preferred embodiments have been described, but those of ordinary skill in the technical field of the present invention will not depart from the spirit and scope of the present invention described in the following claims. It will be appreciated that various modifications and changes can be made to the present invention.

10: LED patch-coupled fusion stent
100: stent structure 200: light therapy unit
210: LED patch 211: light source module
222: battery connection terminal 223: regulator circuit
224: booster circuit 225: driving driver
226: bluetooth circuit 227: antenna
220: battery 230: link line

Claims (11)

A duodenal implantable stent structure having a mesh structure, and
An LED patch having a light source module for irradiating light toward the mucous membrane of the duodenum and a light therapy unit formed by combining a battery stacked while being superimposed on the LED patch,
The phototherapy unit is configured to be connected to each other while being arranged inside and outside the stent structure,
The phototherapy unit includes phototherapy units arranged in three rows at a predetermined interval on the outer outer circumferential surface of the stent structure, and three rows at a predetermined interval on the inner outer circumferential surface of the stent structure. With another phototherapy unit disposed between the phototherapy units in both the longitudinal direction and the circumferential direction,
Further comprising a link line for connecting adjacent units to each other in the longitudinal direction of each of the outer and inner side of the stent structure among the phototherapy units and the other phototherapy units,
The link line is stretched and stretched when the stent structure is contracted, and has a wave shape that returns to its original state when expanded, and between the phototherapy units when the stent structure is contracted and expanded, and the It functions as a mechanical connection to maintain a certain distance between different phototherapy units,
The link line has a redundant structure including a signal line for connecting LED patches included in the phototherapy units and a power line for connecting batteries included in the phototherapy units,
In the contracted state of the stent structure, the phototherapy unit includes light source modules of the phototherapy units installed on the outer outer circumferential surface of the stent structure and the other light treatment installed on the inner outer circumferential surface of the stent structure An LED patch-coupled fusion stent, characterized in that light is irradiated at equal intervals from all directions of an outer surface in a longitudinal direction outside the stent structure in a predetermined section in the longitudinal direction by light source modules of the units.
The method according to claim 1,
The LED patch is on a flexible circuit board having a predetermined elongation.
One or more light source modules forming an array of LEDs for emitting light,
Power connector connected to the battery,
A regulator circuit to maintain and supply a constant voltage,
A booster circuit for boosting a certain voltage supplied from the battery, and
LED patch-coupled fusion stent comprising a driving driver for controlling the operation of the light source module.
The method according to claim 2,
Any one of the LED patches further comprises a Bluetooth circuit including a Bluetooth chip and a Bluetooth antenna, and is controlled using an application installed in a smartphone having a Bluetooth function or an external communication device corresponding thereto. Combined fusion stent.
The method of claim 3,
The antenna is an LED patch-coupled fusion stent, characterized in that formed in the form of being inserted into the thickness of the circuit board.
delete delete delete The method according to claim 1,
By allowing the on/off control signal of the light source module to be transmitted to another LED patch through the signal line, it is possible to perform on/off of the light source module of the LED patch connected as a whole. LED patch-coupled fusion stent.
The method according to claim 1,
By connecting the batteries to each other through the power line, the LED patch-coupled fusion stent, characterized in that it is possible to drive the connected battery in either series or parallel.
The method according to claim 1,
The stent structure is an LED patch-coupled fusion stent, characterized in that a rhombus-shaped mesh structure is formed by connecting a single strand of wire made of an expandable alloy or weaving or crossing a plurality of wires.
The method according to claim 1,
An LED patch-coupled fusion stent, characterized in that the light therapy units stacked and arranged in and out of the stent structure are protected by forming a film through an encapsulation process wrapped with transparent flexible silicone.

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