CN113599717B - Photo-medical device - Google Patents
Photo-medical device Download PDFInfo
- Publication number
- CN113599717B CN113599717B CN202111026846.9A CN202111026846A CN113599717B CN 113599717 B CN113599717 B CN 113599717B CN 202111026846 A CN202111026846 A CN 202111026846A CN 113599717 B CN113599717 B CN 113599717B
- Authority
- CN
- China
- Prior art keywords
- sliding sleeve
- reverse
- light source
- supporting
- support structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- WSNMPAVSZJSIMT-UHFFFAOYSA-N COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 Chemical compound COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 WSNMPAVSZJSIMT-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000013307 optical fiber Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 7
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 239000002096 quantum dot Substances 0.000 claims description 3
- 238000005452 bending Methods 0.000 abstract description 2
- 230000003287 optical effect Effects 0.000 abstract description 2
- 239000000758 substrate Substances 0.000 description 10
- 238000002428 photodynamic therapy Methods 0.000 description 6
- 230000008602 contraction Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- -1 polydimethylsiloxane Polymers 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
- 229920001971 elastomer Polymers 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 239000000017 hydrogel Substances 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 239000004926 polymethyl methacrylate Substances 0.000 description 3
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000000416 hydrocolloid Substances 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 229920000306 polymethylpentene Polymers 0.000 description 2
- 239000011116 polymethylpentene Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 1
- 108090000365 Cytochrome-c oxidases Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004696 Poly ether ether ketone Substances 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 206010043515 Throat cancer Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 1
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 238000001126 phototherapy Methods 0.000 description 1
- 229920000052 poly(p-xylylene) Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 229920002530 polyetherether ketone Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0625—Warming the body, e.g. hyperthermia treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0632—Constructional aspects of the apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0654—Lamps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
- A61N2005/0663—Coloured light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0664—Details
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Non-Portable Lighting Devices Or Systems Thereof (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The application discloses an optical medical device, comprising: the sliding sleeve is sleeved outside the central shaft in a sliding manner; the support structure I and the support structure II are fixed on the outer surface of the sliding sleeve; the supporting structure I and the supporting structure II form a wavy adjusting contour together, and the central shaft is wrapped by the adjusting contour; and the flexible light sources are fixed on the supporting structure I and the supporting structure II, distributed along the adjusting contour and used for providing a treatment light source. The device enters the body in a small-volume structure, and can be unfolded along with the unfolding of the supporting structure after entering the body, so that a large-area treatment light source is provided; the flexible light source is arranged on the surface of the supporting structure, namely, only distributed at the position corresponding to the treatment area, so that the light source loss on the path is avoided; when the supporting structure I and the supporting structure II shrink, the adjusting outline becomes wavy, so that too small bending angles can be avoided, and the flexible light source can be protected.
Description
Technical Field
The present disclosure relates generally to the field of photomedical technology, and more particularly to a photomedical device.
Background
The flexible light source is changeable in shape, so that the flexible light source can be suitable for various occasions, such as indoor illumination, photodynamic therapy and the like. Photodynamic therapy, among others, is a method for treating diseases directly using light or using light and drug combination, and has been currently applied to clinical medicine. There are two main ways of photodynamic therapy, one is direct phototherapy and the other is the synergistic effect of light and a drug (also called photosensitizer). Photodynamic therapy is favored because of its advantages of good selectivity, minimal trauma, good tolerability, simple handling, etc. Photodynamic therapy can be classified into in vivo therapy and in vitro therapy. In vivo treatment includes bladder cancer, throat cancer, bronchial cancer, etc. The light source for in vivo treatment is mainly a laser optical fiber, and the optical fiber has the advantages of easy insertion into the body and small wound. However, the optical fiber has large light energy loss and poor light emitting uniformity, and the light energy irradiated to the focus through the optical fiber is relatively low in the treatment process of a large organ, which is unfavorable for photodynamic therapy.
Disclosure of Invention
In view of the foregoing deficiencies or inadequacies of the prior art, it is desirable to provide an photomedical device that includes:
A central axis of the cylinder,
The sliding sleeve is sleeved outside the central shaft in a sliding manner;
the support structure I and the support structure II are fixed on the outer surface of the sliding sleeve;
The supporting structure I and the supporting structure II form a wavy adjusting contour together, and the central shaft is wrapped by the adjusting contour;
A flexible light source connected to the support structures I and II; the flexible light source is distributed along the adjusting contour and is used for providing a therapeutic light source;
The support structure I and the support structure II are unfolded when the sliding sleeve is stressed, so that the flexible light source is unfolded; the support structures I and II contract such that the adjustment profile becomes wavy.
According to the technical scheme provided by the embodiment of the application, the supporting structure I consists of a plurality of supporting strips I; the support structure II consists of a plurality of support bars III, and the support bars I and the support bars II are circumferentially distributed at intervals;
One end of the supporting bar I is fixed at the end part of the central shaft, and the other end of the supporting bar I is fixed at the upper part of the sliding sleeve;
One end of the support bar II is fixed at the end part of the central shaft, and the other end of the support bar II is fixed at the lower part of the sliding sleeve;
or the sliding sleeve comprises a sliding sleeve I which is slidably sleeved outside the central shaft and a sliding sleeve II which is slidably sleeved outside the sliding sleeve I;
one end of the support bar I is fixed at the end part of the central shaft, and the other end of the support bar I is fixed at the top of the sliding sleeve I;
And one end of the support bar II is fixed at the end part of the central shaft, and the other end of the support bar II is fixed on the outer surface of the sliding sleeve II.
According to the technical scheme provided by the embodiment of the application, the outer peripheral surface of the sliding sleeve can rotate along the length direction of the sliding sleeve to form a plurality of circles of supporting columns, and each circle of supporting column is formed by the interval distribution of long supporting columns and short supporting columns; all long support columns form the support structure I; all short support columns form the support structure II.
According to the technical scheme provided by the embodiment of the application, the top end of the sliding sleeve II is provided with a plurality of grooves at intervals corresponding to the supporting strips I.
According to the technical scheme provided by the embodiment of the application, the flexible light source comprises at least one of an OLED light source, an LED light source, a quantum dot light source, a miniLED light source, a microLED light source and an optical fiber, and the flexible light source is coated with a skin-friendly material layer.
According to the technical scheme provided by the embodiment of the application, the LED lamp further comprises a lamp band, the flexible light source is fixed on the lamp band, and the lamp band is woven on the supporting structure I and the supporting structure II.
According to the technical scheme provided by the embodiment of the application, the flexible light source is fixed on the flexible base material, two sides of the flexible base material are fixed on the adjacent supporting strips I, and the middle part of the flexible base material is fixed on the supporting strips II between the two supporting strips I.
According to the technical scheme provided by the embodiment of the application, the end part of the central shaft is sleeved with a first reverse sliding sleeve outside the adjusting contour; the central shaft is provided with a second reverse sliding sleeve at one side of the sliding sleeve far away from the end part of the sliding sleeve;
The side of first reverse sliding sleeve and second reverse sliding sleeve all articulates has reverse regulation structure, reverse regulation structure is in support structure I and support structure II shrink time form the evagination structure, the maximum width of evagination structure is greater than the maximum width when support structure I and support structure II shrink.
According to the technical scheme provided by the embodiment of the application, the first reverse sliding sleeve and the second reverse sliding sleeve are connected with the sliding sleeve in a linkage manner or are independently connected;
A connecting sleeve is fixedly sleeved at the position, close to the end part, of the central shaft; the connecting sleeve is provided with an axial through hole; the first reverse sliding sleeve is connected with the sliding sleeve through a connecting piece penetrating through the through hole.
According to the technical scheme provided by the embodiment of the application, the reverse adjusting structure comprises a reverse supporting bar hinged on the side surfaces of the first reverse sliding sleeve and the second reverse sliding sleeve and a flexible block fixed at the end part of the reverse supporting bar.
According to the technical scheme provided by the embodiment of the application, the side surfaces of the reverse sliding sleeve are respectively provided with a reverse adjusting structure, the reverse adjusting structures form a convex structure when the supporting structure I and the supporting structure II shrink, and the maximum width of the convex structure is larger than that of the supporting structure when the supporting structure shrinks.
According to the technical scheme provided by the embodiment of the application, the reverse adjusting structure comprises a reverse supporting bar hinged on the side surface of the reverse sliding sleeve and a flexible block fixed at the end part of the reverse supporting bar.
In the technical scheme of the application, a central shaft, a sliding sleeve which is sleeved outside the central shaft in a sliding way, and a supporting structure I and a supporting structure II which are respectively fixed at the upper part and the lower part of the sliding sleeve are designed, wherein the supporting structure I and the supporting structure II form an adjusting contour together; the flexible light source fixed on the supporting structure can be contracted along with the contraction of the supporting structure, so that the device can conveniently enter a body in a small-volume structure, and can be unfolded along with the unfolding of the supporting structure after entering the body, and a large-area therapeutic light source is provided; the flexible light source is arranged on the surface of the supporting structure, namely, only distributed at the position corresponding to the treatment area, so that the light source loss on the path is avoided; when the supporting structure I and the supporting structure II shrink, the adjusting outline becomes wavy, so that too small bending angles can be avoided, and the flexible light source can be protected.
Drawings
Other features, objects and advantages of the present application will become more apparent upon reading of the detailed description of non-limiting embodiments, made with reference to the accompanying drawings in which:
FIG. 1a is a schematic view of an example 1 of the present application without a flexible light source;
FIG. 1b is a schematic view of a flexible light source according to embodiment 1 of the present application;
FIG. 1c is a schematic view of the structure of the embodiment 1 of the present application in which a flexible light source is installed and a sliding sleeve and a pushing cylinder are integrated;
FIG. 1d is a schematic cross-sectional view of embodiment 1of the present application;
FIG. 2a is a schematic view of the structure of embodiment 2 of the present application without a flexible light source;
FIG. 2b is an enlarged schematic view of the top of the sliding sleeve I and the sliding sleeve II according to embodiment 2 of the present application;
FIG. 3a is a schematic view of a flexible light source according to embodiment 3 of the present application;
FIG. 3b is a schematic cross-sectional view of FIG. 3 a;
FIG. 4a is a schematic view showing an expanded structure of a woven strip according to embodiment 4 of the present application;
FIG. 4b is a schematic cross-sectional view of a woven strip according to example 4 of the present application;
FIG. 5a is a schematic diagram of an embodiment of the present application in example 5;
FIG. 5b is an enlarged schematic view of the top end of FIG. 5 a;
FIG. 5c is a schematic view of the cross-sectional structure of the B-B plane of FIG. 5B;
FIG. 5d is a schematic structural view of a second embodiment of example 5 of the present application;
FIG. 5e is a schematic cross-sectional view of the C-C plane of FIG. 5 b;
FIG. 6a is a schematic diagram of embodiment 6 of the present application;
10. A central shaft; 20. a sliding sleeve; 50. a flexible light source; 31. a supporting bar I;41. a support bar II;32. a long support column; 42. a short support column; 61. pushing a cylinder; 61-1, a first pushing cylinder; 61-2, a second pushing cylinder; 51. a power supply line; 51-1, adjusting the allowance; 21. a sliding sleeve I;22. a sliding sleeve II;43. a flat layer; 45-1, a transverse lamp strip; 45-2, longitudinal lamp strips; 81. the first reverse sliding sleeve; 82. the second reverse sliding sleeve; 83. connecting sleeves; 12. a connecting piece; 84. a reverse support bar; 85. a flexible block; 86. a first control end; 87. and a second control terminal.
Detailed Description
The application is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the application and are not limiting of the application. It should be noted that, for convenience of description, only the portions related to the application are shown in the drawings.
It should be noted that, without conflict, the embodiments of the present application and features of the embodiments may be combined with each other. The application will be described in detail below with reference to the drawings in connection with embodiments.
Example 1
Referring to fig. 1, the present embodiment provides an optical medical device, including:
The central axis 10 is provided with a central axis,
A sliding sleeve 20 slidably sleeved outside the central shaft 10;
a support structure I and a support structure II are fixed on the outer surface of the sliding sleeve 20;
An adjustment profile jointly formed by the support structures I and II, which wraps the central shaft 10;
a flexible light source 50 connected to both the support structure I and the support structure II; the flexible light sources 50 are distributed along the adjustment profile for providing a therapeutic light source;
the support structures I and II expand when the sliding sleeve 20 is stressed to expand the flexible light source 50; the support structures I and II contract such that the adjustment profile becomes wavy.
Wherein, in the present embodiment, the central shaft 10 is made of steel wire, thin deformable plastic rod or plastic tube, hollow or solid rubber tube; the end part provided with the supporting structure I and the supporting structure II is used for stretching into the body for treatment, the other end of the supporting structure I and the supporting structure II is exposed out of the body, and the end part exposed out of the body is provided with a control structure.
In this embodiment, the supporting structure I is composed of a plurality of supporting strips I31; the supporting structure II consists of a plurality of supporting strips II 41;
One end of the supporting bar I31 is fixed at the end part of the central shaft 10, and the other end is fixed at the upper part of the sliding sleeve 20;
one end of the supporting bar II41 is fixed at the end part of the central shaft 10, and the other end is fixed at the lower part of the sliding sleeve 20;
The supporting bars I31 and the supporting bars II41 are circumferentially distributed at intervals.
The supporting bar I31 and the supporting bar II41 can also be made of steel wires, thin deformable plastic bars or plastic tubes, hollow or solid rubber tubes. Wherein, the support bar I31 is connected with the flexible light source 50 only at the middle part of the length direction; since support bar I31 is shorter than support bar II41, the spherical profile formed thereby is within the spherical profile formed by support bar II41, and when flexible light source 50 is disposed on both support bar I31 and support bar II41 and support structure I and support structure II are deployed, the ends of support structure II form a spherical or ellipsoidal profile along with which flexible light source 50 is deployed; when the support structures I and II shrink, as shown in fig. 1d, a wavy adjustment profile is formed, and the flexible light source 50 forms a wavy surface, so that the flexible light source 50 between two adjacent support bars II41 is prevented from being damaged due to an excessively large folding angle when shrinking, and the flexible light source 50 is protected.
For ease of viewing, the contoured surfaces of support structure I and support structure II provided in fig. 1a are not provided with flexible light sources 50; the support structures I and II provided in fig. 1b are covered by a flexible light source 50.
The control structure may alternatively take the following form:
1. As shown in fig. 1a and 1b, the central shaft 10 is sleeved with a push tube 61, the push tube 61 is fixedly connected with the end surface of the sliding sleeve 20, and the end part of the push tube 61 is exposed.
At this time, the power supply line 51 of the flexible light source 50 is provided by attaching to the outer surfaces of the sliding sleeve 20 and the push barrel 61 in such a manner that an adjustment margin 51-1 is provided at the junction of the sliding sleeve 20 and the support structure.
2. As shown in fig. 1c, the length of the sliding sleeve 20 extends along with the length direction of the central shaft 10, and the end portion is exposed directly, so that when the sliding sleeve is used, the sliding control of the sliding sleeve 20 is realized by providing axial pushing force or pulling force for the exposed end of the sliding sleeve 20, and further the control of the expansion and contraction of the supporting structure is realized.
At this time, the power supply line 51 of the flexible light source 50 is attached to the outer surface of the sliding sleeve 20 in such a manner that an adjustment margin 51-1 is provided at the junction of the sliding sleeve 20 and the supporting structure.
In this embodiment, the flexible light source 50 is fixed on a flexible substrate, two sides of the flexible substrate are fixed on the adjacent support bars II41, and the middle part of the flexible substrate is fixed on the support bar I31 between the two support bars II 41. When the support structures I and II shrink, the flexible light source 50 is folded along with the central line of the flexible substrate, and the central shaft 10 is rotated clockwise or anticlockwise at this time, so that the folded flexible light source 50 and the flexible substrate 60 can be curled; if the flexible light source 50 is turned on before treatment, after entering the body, the central shaft 10 is rotated counterclockwise.
In this embodiment, the flexible substrate is a rubber sheet, and the flexible light source 50 is an OLED light source substantially conforming to the shape of the flexible substrate, and is fixed on the flexible substrate by adhesive, and the edge of the flexible substrate is fixed on the supporting structure by adhesive. In other embodiments, the flexible light source 50 may be a plurality of OLED light sources, LED light sources, quantum dot light sources, miniLED light sources, microLED light sources, or optical fibers arranged on a flexible substrate, or a combination of any two or three of the foregoing.
In other embodiments, the flexible light source 50 is overcoated with a layer of skin-friendly material, such as a material of silicone gel, polydimethylsiloxane (PDMS), silicone gel, collagen (Collagen), silicone gel (Silicone Hydrogel), hydrogel (Hydrogel), hydrocolloid (Hydrocolloid), polyurethane (PU), polymethyl methacrylate (PMMA), polymethylpentene polymer (PMP), polyethylene (PE), polycarbonate, polystyrene, acrylonitrile butadiene styrene, polyolefin, polyamide, polyvinyl chloride, polyethylene, polypropylene, nylon, polyester, silicone, polyimide, polytetrafluoroethylene, polyethersulfone, polysulfone, polyetheretherketone, chitosan, pectin, gelatin, nylon, fiber, and the like.
When the flexible light source 50 is disposed on the surface of the support structure, the support structure is deployed closer to the focal zone than in the single fiber treatment of the prior art, thereby avoiding loss due to liquid. For example, some lesions are relatively large in organs such as bladder, and sometimes can block the affected part, and the whole bladder is supported by filling liquid during treatment, and light loss is caused by the existence of the liquid, especially in the case of a single optical fiber, the liquid needs to be transmitted from the end part of the optical fiber to the lesion, and the light loss is very serious; in the technical scheme of the application, the light source can be closer to the focus part by the supporting structure, the distance of light penetrating through the liquid is shorter, and correspondingly, the light loss is much smaller.
In this embodiment, the color of the flexible light source 50 may be red light, blue-green light or blue light, or a light source with a mixture of colors:
The light irradiation depth of yellow green light with the wave band of 510 nm-590 nm is between blue light and red light, so that the dredging and the expansion of capillary vessels with the skin depth can be promoted, the resistance of cells can be enhanced, and the treatment effect of an affected part can be accelerated.
Red light with the wave band of 590-810 nm can lead mitochondria to release cytochrome c oxidase, increase adenosine triphosphate, and the cells provide energy by using the adenosine triphosphate, thereby promoting the metabolism of the cells; meanwhile, the red light irradiation heats molecules in blood vessels, regulates the vasodilation and improves the blood circulation;
Blue light irradiation in the 440-510 nm band can be used for relieving pain and swelling caused by inflammation. Therefore, the embodiment can achieve a plurality of different treatment effects by arranging different light sources.
When the photomedical device according to the present embodiment is used for in vivo treatment, the support structures I and II and the flexible light source 50 can be introduced into the body by pushing the central shaft 10. The photomedical device provided in this embodiment may also be used for extracorporeal treatment by selectively energizing portions of the flexible light source 50 to effect localized treatment.
Example 2
As shown in fig. 2a and 2b, in this embodiment, based on embodiment 1, the sliding sleeve 20 includes a sliding sleeve I21 slidably sleeved outside the central shaft 10, and a sliding sleeve II22 slidably sleeved outside the sliding sleeve I21; the support structure I consists of a plurality of support bars I31, and the support structure II consists of a plurality of support bars II 41;
One end of the supporting bar I31 is fixed at the end part of the central shaft 10, and the other end of the supporting bar I is fixed at the top of the sliding sleeve I21;
And one end of the supporting bar II41 is fixed at the end part of the central shaft 10, and the other end of the supporting bar II is fixed on the outer surface of the sliding sleeve II 22.
Wherein, a plurality of grooves are arranged at intervals on the top end of the sliding sleeve II22 corresponding to the supporting bar I31. In this embodiment, the lengths of the supporting bar I31 and the supporting bar II41 are substantially identical, and after the supporting structures I and II are unfolded, a circular outline can be formed, so that the flexible light source 50 is more uniformly distributed; after the supporting structure I and the supporting structure II shrink, the sliding sleeve I21 and the sliding sleeve II22 are controlled independently, so that the sliding sleeve I21 can shrink into the sliding sleeve II22 when shrinking, and the supporting bar I31 shrinks to a larger degree relative to the supporting bar II41, thereby forming a wavy adjusting profile.
In this embodiment, the sliding sleeve I21 is driven by the first pushing cylinder 61-1, and the sliding sleeve II22 is driven by the second pushing cylinder 61-2; the second pushing barrel 61-2 is sleeved outside the first pushing barrel 61-1;
Example 3
The implementation manner of the support structure I and the support structure II in this embodiment is changed to:
As shown in fig. 3a and 3b, the outer peripheral surface of the sliding sleeve 20 is rotatable along the length direction thereof to form a plurality of circles of support columns, and each circle of support columns is formed by a long support column 32 and a short support column 42 which are distributed at intervals; all long support columns 32 form the support structure I; all short support columns 42 form the support structure II.
At this time, wavy profile surfaces are formed when the support structure I and the support structure II are expanded and contracted.
Example 4
In the technology of embodiment 1, the arrangement mode of the flexible light source 50 is replaced by a structure of a woven light band, in this embodiment, as shown in fig. 4a, the light band comprises a transverse light band 45-1 and a longitudinal light band 45-2; the transverse light strip 45-1 and the longitudinal light strip 45-2 are woven on the supporting structure 30, and the transverse light strip 45-1 and the longitudinal light strip 45-2 may be made of thin rubber sheets, for example.
In this embodiment, the light sources are LED beads, and are connected by parallel or serial circuits, and the horizontal light strip 45-1 and the vertical light strip 45-2 are provided with a flat layer 43 covering all the light sources, and the flat layer 43 is made of an organic material, such as PMMA, parylene, etc., and has a thickness 10 μm-50 μm higher than that of the light sources. The flat layer 43 allows the strip to be relatively flat, improving comfort during use.
In other embodiments, the LED lamp beads can be replaced by optical fibers or OLED light sources, and the optical fibers are attached to the transverse lamp strip 45-1 and the longitudinal lamp strip 45-2 along the length direction;
The light-emitting area of the single light strip is smaller, and the light-emitting area of the braided light strip is larger than that of the single light strip; since the lamps arranged throughout the strip are individual and have uniform illumination, the overall braided strip form will have better illumination uniformity relative to the bulk of the flexible light source 50; because the bulk flexible light source 50 emits light more darkly at locations away from the bonding region, it emits light more brightly at locations closer to the bonding region.
Example 5
In this embodiment, on the basis of embodiment 2, a first reverse sliding sleeve 81 is sleeved on the end portion of the central shaft 10 outside the adjustment profile; the central shaft 10 is provided with a second reverse sliding sleeve 82 at one side of the sliding sleeve 20 far from the end part thereof;
the sides of the first reverse sliding sleeve 81 and the second reverse sliding sleeve 82 are hinged with reverse adjusting structures, the reverse adjusting structures form convex structures when the supporting structures I and the supporting structures II shrink, and the maximum width of the convex structures is larger than that of the supporting structures I and the supporting structures II when the supporting structures II shrink.
According to the technical scheme provided by the embodiment of the application, the reverse adjusting structure comprises a reverse supporting bar 84 hinged on the side surfaces of the first reverse sliding sleeve 81 and the second reverse sliding sleeve 82 and a flexible block 85 fixed on the end part of the reverse supporting bar 84.
When the photomedical device enters the body or is taken out of the body, the reverse adjusting structure forms a convex structure at two sides of the supporting structure, so that on one hand, the supporting structure can conveniently take the flexible light source 50 out of the body or enter the body, in addition, the contact with other skin tissues can be avoided in the process of entering or exiting the flexible light source 50, and the flexible light source 50 can be protected.
The sliding control of the first reverse sliding sleeve 81 and the second reverse sliding sleeve 82 may adopt linkage control or may adopt an independent control mode:
1. The linkage control, as shown in fig. 5a to 5c, the first reverse sliding sleeve 81 and the second reverse sliding sleeve 82 are both linked with the sliding sleeve 20;
Wherein, the central shaft 10 is sleeved and fixed with a connecting sleeve 83 near the end part; the connecting sleeve 83 is provided with an axial through hole; the first reverse sliding sleeve 81 is connected with the sliding sleeve 20 in a linkage manner through the connecting piece 12 passing through the through hole.
The second reverse sliding sleeve 82 is directly and fixedly connected with the end face of the sliding sleeve 20, so that linkage control is realized; the push-pull of the sliding sleeve 20 and the first reverse sliding sleeve 81 is realized when the push barrel 61 pushes and pulls the second reverse sliding sleeve 82.
In the case of coordinated control:
Support structure I and support structure II shrink: the included angle a between the reverse support bar 84 on the first reverse sliding sleeve 81 and the axial end direction of the central shaft 10 is an acute angle; the included angle b between the reverse support bar 84 of the second reverse sliding sleeve 82 and the direction away from the shaft end of the central shaft 10 is an acute angle;
When the support structure is fully deployed: the included angle between the reverse support bar 84 of the first reverse sliding sleeve 81 and the shaft end direction of the central shaft 10 is about 90 degrees, and the first reverse sliding sleeve is in a locking state; the included angle b between the reverse support bar 84 of the second reverse sliding sleeve 82 and the direction far from the shaft end of the central shaft 10 is about 90 degrees, and the second reverse sliding sleeve is in a locking state.
2. The independent control is shown in fig. 5d-5e, and a connecting sleeve 83 is sleeved and fixed at the position, close to the end, of the central shaft 10; the connecting sleeve 83 is provided with an axial through hole; the connector 12 extends all the way with the central shaft 10 to form a first control end 86 at the exposed end; the expansion and contraction of the back support bar 84 on the first back slide sleeve 81 can be controlled by pushing and pulling the first control end 86;
The second reverse sliding sleeve 82 is sleeved outside the connecting end of the push sleeve 61 and the sliding sleeve 20, and the second reverse sliding sleeve 82 extends along with the push sleeve 61 to form a second control end 87 at the exposed end;
The expansion and contraction of the reverse regulation structure on the first reverse sliding sleeve 81 are realized by pushing and pulling the first control end 86; the expansion and contraction of the reverse adjustment mechanism on the second reverse sliding sleeve 82 is accomplished by pushing and pulling the second control end 67.
The independent control mode can bring more convenience to use, for example, the first reverse sliding sleeve 81 can only form an outer convex structure when entering the body; only the second reverse sliding sleeve 82 is allowed to form a male configuration when removed from the body.
Example 6
This embodiment is based on embodiment 3, as shown in fig. 6a, the end of the central shaft 10 is outside the adjustment profile, and the central shaft 10 is provided with a reverse sliding sleeve on the side of the sliding sleeve 20 away from the end thereof; the reverse sliding sleeve at the end of the central shaft 10 is a first reverse sliding sleeve 81, and the reverse sliding sleeve at the side of the central shaft 10 away from the end of the sliding sleeve 20 is a second reverse sliding sleeve 82; a first reverse slide sleeve 81 and a second reverse slide sleeve 82 are coupled to the slide sleeve 20.
The side of the reverse sliding sleeve is provided with a reverse adjusting structure, the reverse adjusting structure forms a convex structure when the supporting structure I and the supporting structure II shrink, and the maximum width of the convex structure is larger than that of the supporting structure when the supporting structure shrinks.
According to the technical scheme provided by the embodiment of the application, the reverse adjusting structure comprises a reverse supporting bar 84 hinged on the side surface of the reverse sliding sleeve and a flexible block 85 fixed on the end part of the reverse supporting bar 84.
When the photomedical device enters the body or is taken out of the body, the reverse adjusting structure forms a convex structure at two sides of the supporting structure, so that on one hand, the supporting structure can conveniently take the flexible light source 50 out of the body or enter the body, in addition, the contact with other skin tissues can be avoided in the process of entering or exiting the flexible light source 50, and the flexible light source 50 can be protected.
In other implementations of this embodiment, the first reverse sliding sleeve 81, the second reverse sliding sleeve 82, and the sliding sleeve 20 may also be controlled separately or in a coordinated manner as described in embodiment 5, which is not described herein.
The above description is only illustrative of the preferred embodiments of the present application and of the principles of the technology employed. It will be appreciated by persons skilled in the art that the scope of the application referred to in the present application is not limited to the specific combinations of the technical features described above, but also covers other technical features formed by any combination of the technical features described above or their equivalents without departing from the inventive concept. Such as the above-mentioned features and the technical features disclosed in the present application (but not limited to) having similar functions are replaced with each other.
Claims (8)
1. A photomedical device, comprising:
A central axis of the cylinder,
The sliding sleeve is sleeved outside the central shaft in a sliding manner;
A support structure I and a support structure II fixed to the outer surface of the sliding sleeve;
the support structure I and support structure II together form an adjustment profile that wraps around the central axis;
A flexible light source coupled to both the support structure I and the support structure II; the flexible light source is distributed along the adjusting contour and is used for providing a therapeutic light source;
The support structure I and support structure II expand when the sliding sleeve is forced to expand the flexible light source; the support structure I and support structure II collapse such that the adjustment profile becomes wavy;
The outer peripheral surface of the sliding sleeve can rotate along the length direction of the sliding sleeve to form a plurality of circles of supporting columns, and each circle of supporting column is formed by long supporting columns and short supporting columns in an interval distribution mode; all long support columns form the support structure I; all short support columns form the support structure II.
2. The photomedical device of claim 1, wherein the support structure I is comprised of a plurality of support bars I; the supporting structure II is composed of a plurality of supporting bars II, and the supporting bars I and the supporting bars II are circumferentially distributed at intervals;
one end of the supporting bar I is fixed at the end part of the central shaft, and the other end of the supporting bar I is fixed at the upper part of the sliding sleeve;
One end of the supporting bar II is fixed at the end part of the central shaft, and the other end of the supporting bar II is fixed at the lower part of the sliding sleeve;
Or the sliding sleeve comprises a sliding sleeve I which is slidably sleeved outside the central shaft and a sliding sleeve II which is slidably sleeved outside the sliding sleeve I;
One end of the supporting bar I is fixed at the end part of the central shaft, and the other end of the supporting bar is fixed at the top of the sliding sleeve I;
one end of the supporting bar II is fixed at the end of the central shaft, and the other end of the supporting bar is fixed at the outer surface of the sliding sleeve II.
3. The photomedical device of claim 2, wherein the top end of the sleeve II is provided with a plurality of grooves spaced apart corresponding to the support bars I.
4. The photomedical device of claim 1, wherein the flexible light source comprises at least one of an OLED light source, an LED light source, a quantum dot light source, a miniLED light source, a microLED light source, an optical fiber; the flexible light source is coated with a skin-friendly material layer.
5. The photomedical device of any one of claims 1 to 4, further comprising a light strip having the flexible light source secured thereto, the light strip being woven over the support structure I and support structure II.
6. The photomedical device of claim 1 or 2, wherein,
The end part of the central shaft is sleeved with a first reverse sliding sleeve outside the adjusting profile; the central shaft is provided with a second reverse sliding sleeve at one side of the sliding sleeve far away from the end part of the sliding sleeve;
The sides of the first reverse sliding sleeve and the second reverse sliding sleeve are hinged with reverse adjusting structures, the reverse adjusting structures form a convex structure when the supporting structures I and the supporting structures II shrink, and the maximum width of the convex structure is larger than that of the supporting structures I and II when the supporting structures shrink.
7. The photomedical device of claim 6, wherein the first and second inverse sliding sleeves are connected in tandem or independently of the sliding sleeve; a connecting sleeve is fixedly sleeved at the position, close to the end part, of the central shaft; the connecting sleeve is provided with an axial through hole; the first reverse sliding sleeve is connected with the sliding sleeve through a connecting piece penetrating through the through hole; the reverse adjusting structure comprises a reverse supporting bar hinged on the side surfaces of the first reverse sliding sleeve and the second reverse sliding sleeve, and a flexible block fixed at the end part of the reverse supporting bar.
8. The photomedical device of claim 7, wherein the sides of the inverted sliding sleeve are each provided with an inverted adjustment structure that forms a convex structure when the support structure I and support structure II are collapsed, the maximum width of the convex structure being greater than the maximum width of the support structure when collapsed; the reverse adjusting structure comprises a reverse supporting bar hinged on the side face of the reverse sliding sleeve and a flexible block fixed at the end part of the reverse supporting bar.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111026846.9A CN113599717B (en) | 2021-09-02 | 2021-09-02 | Photo-medical device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111026846.9A CN113599717B (en) | 2021-09-02 | 2021-09-02 | Photo-medical device |
Publications (2)
Publication Number | Publication Date |
---|---|
CN113599717A CN113599717A (en) | 2021-11-05 |
CN113599717B true CN113599717B (en) | 2024-07-16 |
Family
ID=78309953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202111026846.9A Active CN113599717B (en) | 2021-09-02 | 2021-09-02 | Photo-medical device |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN113599717B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117281612B (en) * | 2023-11-24 | 2024-02-06 | 四川大学华西医院 | Photosensitizer inducing device |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008046019A1 (en) * | 2006-10-11 | 2008-04-17 | Light Sciences Oncology, Inc. | Light delivery apparatus and methods for illuminating internal tissues |
WO2014079972A1 (en) * | 2012-11-23 | 2014-05-30 | Photocure Asa | Device for photodynamic treatment |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5445608A (en) * | 1993-08-16 | 1995-08-29 | James C. Chen | Method and apparatus for providing light-activated therapy |
WO2001008575A2 (en) * | 1999-07-30 | 2001-02-08 | Cardiofocus, Inc. | Optical fiber basket device for cardiac photoablation |
WO2003020103A2 (en) * | 2001-09-04 | 2003-03-13 | Amit Technology Science & Medicine Ltd. | Method of and device for therapeutic illumination of internal organs and tissues |
US7153299B1 (en) * | 2003-02-24 | 2006-12-26 | Maxwell Sensors Inc. | Optical apparatus for detecting and treating vulnerable plaque |
WO2007092108A2 (en) * | 2006-02-07 | 2007-08-16 | Boston Scientific Limited | Medical device light source |
JP5702529B2 (en) * | 2009-10-26 | 2015-04-15 | 良典 丸中 | Medical light irradiation device |
WO2014032096A1 (en) * | 2012-08-29 | 2014-03-06 | The Bionics Institute Of Australia | Electrical apparatus and methods and apparatus for positioning and implanting components thereof |
KR101754026B1 (en) * | 2016-04-29 | 2017-07-04 | 금오공과대학교 산학협력단 | Biopsy forceps for endoscope |
CN110393862A (en) * | 2019-08-28 | 2019-11-01 | 武汉优瑞科技有限公司 | A kind of photon therapeutic equipment for ear treatment |
-
2021
- 2021-09-02 CN CN202111026846.9A patent/CN113599717B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008046019A1 (en) * | 2006-10-11 | 2008-04-17 | Light Sciences Oncology, Inc. | Light delivery apparatus and methods for illuminating internal tissues |
WO2014079972A1 (en) * | 2012-11-23 | 2014-05-30 | Photocure Asa | Device for photodynamic treatment |
Also Published As
Publication number | Publication date |
---|---|
CN113599717A (en) | 2021-11-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN113599715B (en) | Photo-medical device | |
ES2689302T3 (en) | Light supply device that provides a radial pattern of light emission | |
CN1173670C (en) | Improved phototherapeutic methods and devices for irradiating columnar environments | |
AU723899B2 (en) | Flexible and adjustable grid for medical therapy | |
US20070142880A1 (en) | Light delivery apparatus | |
US20040039242A1 (en) | Apparatus and methods using visible light for debilitating and/or killing microorganisms within the body | |
CN113599717B (en) | Photo-medical device | |
US20110264174A1 (en) | Light Emmitting Apparatus | |
EP0820786A3 (en) | Photodynamic therapy balloon catheter with microporous membrane | |
CN113599716B (en) | Photo-medical device | |
CN113730825B (en) | Phototherapy device | |
JP7273903B2 (en) | Tissue irradiation device and methods and kits using same | |
CN113577576B (en) | Photo-medical device | |
JP6858707B2 (en) | Optical fiber for light diffusion whose length and illumination pattern can be changed under control | |
CN114028731B (en) | Waist shaping phototherapy device | |
CN113730824B (en) | Phototherapy device | |
CN114191722B (en) | Flexible phototherapy device and bandage for wound treatment | |
US11937789B2 (en) | Device and method for hemorrhoid treatment via rectum expansion and specific spectral illumination | |
KR102567070B1 (en) | LED-cap assisted endoscopic low-level laser therapy | |
JP2020005843A (en) | Natural ostium dilating applicator | |
KR100314896B1 (en) | Device for treatment of a cavity disease | |
WO2022158075A1 (en) | Light-emitting medical apparatus | |
RU2732829C1 (en) | Method for phototherapeutic irradiation of pathological area in living being and lighting device for implementation thereof | |
US20230390576A1 (en) | Light irradiation medical device | |
KR20240095664A (en) | Patch using near infrared application state transition system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |