WO2021256596A1

WO2021256596A1 - Led patch-combined stent

Info

Publication number: WO2021256596A1
Application number: PCT/KR2020/008494
Authority: WO
Inventors: 사기동; 김자연; 김사웅; 정지호
Original assignee: 한국광기술원
Priority date: 2020-06-18
Filing date: 2020-06-30
Publication date: 2021-12-23
Also published as: KR102222588B1

Abstract

The present invention relates to an LED patch-combined stent that is inserted into the duodenum to treat diabetes or fatty liver, the LED patch-combined stent comprising: a mesh-shaped duodenum-insertable stent structure; a phototherapy unit that is formed by joining an LED patch, having a light source module for irradiating a mucous membrane of the duodenum with light, and batteries stacked on the LED patch while overlapping same, and included is the structure in which one or more phototherapy units are connected to each other and arranged inside and outside the stent structure.

Description

LED patch-coupled stent

The present invention relates to an LED patch-coupled stent, and more particularly, to an LED patch-coupled stent inserted into the duodenum for the treatment of diabetes or fatty liver.

When the flow of blood or body fluid, such as blood vessels, gastrointestinal tract, and bile duct, is not smooth due to the occurrence of malignant or benign diseases, it is inserted into a narrowed or blocked area under X-ray fluoroscopy without performing a surgical operation to reduce the flow. It is a cylindrical medical material used for normalization.

The advantage of an interventional procedure using a stent is that it is simpler than the method through surgery, can reduce the burden of general anesthesia, and has a high success rate, so it is widely used worldwide.

According to the mechanism of action to secure the lumen, there are two types of stents: a balloon-expanding type using a balloon and a self-inflating stent using a shape-memory alloy. As the material of the self-expanding stent, stainless steel and Nitinol, a shape memory alloy, are widely used.

On the other hand, since obese patients may be accompanied by fatty liver or diabetes, one of the metabolic syndromes, a method that can expect treatment of obesity and fatty liver or diabetes at the same time is needed. However, it is known that the duodenal mucosa plays an important role in the development of obesity and diabetes.

Accordingly, there is a duodenal mucosal resurfacing technique using an endoscope called duodenal mucosal resurfacing (DMR) for inducing metabolic improvement of the duodenal mucosal layer. Therefore, the DMR method has a disadvantage in that the duodenal mucosa is burned by heating the duodenal mucosa to a temperature of 80°C for about 5 minutes, and complications, pain, and stenosis may occur.

In other words, in the case of obese patients, it partially restricts the normal absorption of nutrients from ingested food into the human body from the small intestine such as the duodenum, kills pathological cells of the duodenal mucosa due to stent expansion, and regenerates the duodenal mucosa according to ischemic changes. , there is a need for a stent that can help the treatment of obesity, fatty liver and diabetes patients.

The present invention was derived to solve the problems of the prior art described above, and an object of the present invention is to mount an ultra-small light emitting diode (LED) device that is a light source the size of a hair on a flexible substrate for the treatment of diabetes or fatty liver, and is flexible An object of the present invention is to provide an LED patch-coupled stent that emits light to the duodenal mucosa by stacking one or more units for phototherapy combined with a thin film battery in a stent structure.

In addition, another object of the present invention is a combination of an LED patch capable of controlling the operation of a plurality of light source modules of the light therapy unit installed in the stent structure using a wirelessly connected smartphone or an application installed in a corresponding external communication device. It is intended to provide a type stent.

In addition, another object of the present invention is a convergence device, a plurality of light source modules of the unit for phototherapy are arranged inside and outside the stent structure, and LED patch-coupled type that can uniformly irradiate light to the outside even after contraction To provide a stent.

LED patch-coupled stent according to an aspect of the present invention for solving the above technical problem is a duodenal insertion-type stent structure having a mesh structure and an LED having a light source module for irradiating light to the mucous membrane of the duodenum It consists of a patch and a battery stacked while being superimposed on the LED patch is combined for a phototherapy unit, and the phototherapy unit is arranged in one or more inner and outer sides of the stent structure and is characterized in that it is connected to each other. .

In addition, the LED patch of the present invention is supplied by maintaining one or more light source modules that form an array of LEDs for emitting light on a flexible circuit board having a predetermined elongation, a power terminal connected to a battery, and a constant voltage. It has a characteristic comprising a regulator circuit for doing so, a booster circuit for boosting a constant voltage supplied from the battery, and a driving driver for controlling the operation of the light source module.

In addition, any one of the LED patches of the present invention further comprises a Bluetooth circuit including a Bluetooth chip and a Bluetooth antenna, and is controlled using an application installed in a smartphone having a Bluetooth function or a corresponding external communication device. There is this.

In addition, the antenna of the present invention is characterized in that it is embedded in the thickness of the circuit board.

In addition, the phototherapy unit of the present invention is arranged in a line with a predetermined number at a predetermined interval at each position divided at an angle of 120 degrees along the outer peripheral surface of the stent structure along the outer peripheral surface of the stent structure, the outer peripheral surface along the inner peripheral surface of the stent structure There is a feature in that a certain number of light source modules are connected and arranged at regular intervals in a line at each position divided at an angle of 120 degrees so as to deviate from the arrangement of the phototherapy units disposed on the outer circumferential surface, so that the light source modules are spaced apart from each other at the same distance.

In addition, the phototherapy unit of the present invention is provided with a link line for connecting each to each other, and the link line is stretched while the stent structure is contracted when it is contracted, and when the stent structure is contracted, it is wavy to return to its original state. ) in the shape of a design.

In addition, the link line of the present invention is characterized in that it has a dual structure including a signal line for connecting the LED patch included in the phototherapy unit and a power line for connecting the power sources of the battery.

In addition, by allowing the on/off control signal of the light source module to be transmitted to another LED patch through the signal line of the present invention, the on/off of the light source modules of the plurality of LED patches connected as a whole, etc. It has the characteristic of performing operation control of

In addition, since the batteries are connected to each other through the power line of the present invention, the connected batteries are driven either in series or in parallel.

In addition, the stent structure of the present invention is characterized by forming a rhombus-shaped mesh structure by connecting a single strand of wire made of an expandable alloy or weaving or crossing a plurality of wires.

In addition, the phototherapy unit stacked on the inside and outside of the stent structure of the present invention is protected by forming a film through an encapsulation process wrapped with transparent flexible silicone.

The present invention by the above-described LED patch-coupled stent can provide an effect of minimizing pathological cell death in the mucosal layer, inducing metabolic improvement through normal mucosal regeneration, and minimizing duodenal stenosis using low-temperature ablation (LTT) of LED.

In addition, the LED patch-coupled stent according to the present invention has no complications, can be operated multiple times, and provides an effect that can treat fatty liver without the need for diabetes medication for several months or more with one treatment.

In addition, the LED patch-coupled stent according to the present invention has the effect of enabling safe and convenient use by integrating the phototherapy unit through a process of encapsulating it with transparent flexible silicone.

In addition, the LED patch-coupled stent according to the present invention controls to turn on/off the light source module of the phototherapy unit using an application installed in a wirelessly connected smartphone or a corresponding external communication device, It has the effect of minimizing the induction of pain through irradiation.

1 is a perspective view showing the appearance of an LED patch-coupled stent according to an embodiment of the present invention.

Figure 2 is a perspective view of the LED patch-coupled stent of Figure 1 viewed from another side.

Figure 3 is a side view showing the state before and after the contraction of the LED patch-coupled stent of Fig. 1 .

4 is a front view showing the state before and after the contraction of the LED patch-coupled stent of FIG. 1 .

5 is a partially enlarged side view showing the state before and after contraction of the LED patch-coupled stent of FIG. 1 .

Figure 6 is a side view showing the state before and after the contraction of the LED patch-coupled stent according to another embodiment of the present invention.

7 is a block diagram of a configuration of an LED patch that can be employed in the LED patch-coupled stent according to an embodiment of the present invention.

FIG. 8 is a block diagram illustrating the LED patch of FIG. 7 .

Figure 9 is an exemplary view of the use state of the LED patch-coupled stent according to an embodiment of the present invention.

10 and 11 are graphs of results obtained in a diabetic animal model experiment using an LED patch-coupled stent according to an embodiment of the present invention.

The terms or words used in the present specification and claims should not be construed as being limited to their ordinary or dictionary meanings, and the inventor may properly define the concept of the term in order to best describe his invention. Based on the principle that there is, it should be interpreted as meaning and concept consistent with the technical idea of the present invention.

Therefore, the configuration shown in the embodiments and drawings described in this specification is only the most preferred embodiment of the present invention and does not represent all of the technical idea of the present invention, so various equivalents that can be substituted for them at the time of the present application It should be understood that there may be water and variations.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1 is a perspective view showing the appearance of an LED patch-coupled stent according to an embodiment of the present invention. Figure 2 is a perspective view of the LED patch-coupled stent of Figure 1 viewed from another side. Figure 3 is a side view showing the state before and after the contraction of the LED patch-coupled stent of Fig. 1 . And Figure 4 is a front view showing the state before and after the contraction of the LED patch-coupled stent of Fig. 1 .

1 to 4, the LED patch-coupled stent 10 according to the present embodiment is an implantable stent structure 100 having a mesh structure, and for irradiating light to the stent structure 100 The LED patch 210 having the light source module 211 and the battery 220 stacked while being superimposed on the LED patch 210 are combined to include a unit 200 for phototherapy.

The stent structure 100 may have a wire mesh structure in the form of a rhombus by connecting one strand of wire or weaving or crossing a plurality of strands of wire. The stent structure 100 has a shape in which the diameter of both ends when viewed from the side has a larger diameter than the diameter of the middle part between the ends, and when viewed from the front, some wires surround the edge of the circular center in the form of a gap in the center. can That is, the stent structure 100 may include a stent structure 100a in the middle of the first outer diameter and a stent structure 100b at both ends having a shape that gradually spreads from the circular center to an outer diameter larger than the first outer diameter.

The stent structure 100 is not particularly limited as long as its diameter is reduced to 1/2 to 1/3 when pulled in the longitudinal direction and most of the inside is exposed to the outside due to a relatively thin wire.

In addition, the stent structure 100 is an expandable alloy structure in which a nanostructure is effectively formed on the surface, and a material of nitinol, a shape memory alloy whose shape changes according to the temperature of the body, may be used, but is limited thereto no.

The above-described stent structure 100 may be in close contact while maintaining the curved shape of the inner wall of the duodenum by applying a coupling structure in which the expansion force is set differently for each part according to the curved structure of the duodenum.

The phototherapy unit 200 includes a first phototherapy unit 210 installed outside the stent structure 100 and a second phototherapy unit 220 installed inside the stent structure 100 . . Each of the first light treatment unit 210 and the second light treatment unit 220 includes at least one light source module 211 . The light source module 211 may be a light emitting diode (LED) device, but is not particularly limited as long as it is a light source capable of emitting light of a similar or appropriate wavelength to the LED.

Each of the unit units of the first unit for phototherapy 210 and the unit units of the second unit for phototherapy 220 are point-coupled in a spot-welding form or the like from the inside or outside of the stent structure 100, or in a ring-coupled form, etc. It can be movably coupled in situ. The coupling structure of the stent structure 100 and the first unit for phototherapy 210, and the coupling structure of the stent structure 100 and the second unit for phototherapy 220 are related to the contraction of the stent structure 100 and During the restoration operation, the reciprocating motion of the first unit for phototherapy 210 and the second unit for phototherapy 220 is possible.

That is, the phototherapy unit 200 is arranged to be connected to each other in a predetermined arrangement from the inside and the outside of the stent structure 100, along the outer peripheral surface of the stent structure 100, each position divided at an angle of 120 degrees in a line at a constant It is arranged to be connected with an interval, and is also arranged to be connected in a line with a predetermined interval at a position separated at an angle of 120 degrees along the outer circumferential surface of the inner side of the stent structure 100 .

In this embodiment, the unit for phototherapy 200 is arranged in a line with four units for phototherapy 200 spaced at regular intervals at every three points in three lines divided at an angle of 120 degrees to the outer peripheral surface of the stent structure 100 . And, as the inner outer circumferential surface of the stent structure 100, the light treatment unit 200 is divided into three lines at an angle of 120 degrees to shift each other from the arrangement of the light treatment unit 200 disposed on the outer outer circumferential surface. They are spaced apart at regular intervals and are formed to be arranged in a line.

Therefore, the phototherapy unit 200 according to this embodiment is the outer peripheral surface of the stent structure 100, in the form of 3x4, 12 units for phototherapy 200 are arranged at regular intervals, the inner peripheral surface of the stent structure 100 As a 3x3 form, nine units for phototherapy 200 are arranged at regular intervals.

In other words, the first units for phototherapy 210 are arranged in three rows along the longitudinal direction of the stent structure 100 on the outer surface of the stent structure (100). On the cross section of the stent structure 100 , the first phototherapy unit 210 has a form in which four unit units are arranged in a row in each column in a 120 degree direction. In this embodiment, the first phototherapy unit 210 includes four unit units 210a in a first row, four unit units 210b in a second row, and four units 210c in a third row. do. Adjacent units of the four unit units 210a; 210b; 210c in each row may be connected to each other by a first link line 230a. The first link line 230a may be configured to transmit signals and power from at least one unit to the other units.

The second phototherapy units 220 are arranged in three rows along the longitudinal direction of the stent structure 100 on the inner surface of the stent structure 100 . On the cross-section of the stent structure 100 , the second phototherapy unit 220 has a form in which three unit units are arranged in a row in each row in a 120 degree direction. In this embodiment, the second phototherapy unit 220 includes three unit units 220a in a first row, three unit units 220b in a second row, and three units 220c in a third row. do. The three unit units 220a; 220b; 220c in each row may be connected to each other by a second link line 230b. The second link line 230b may be configured to transmit signals and power.

In the aforementioned stent 10 , before contraction of the stent 10 , the second light treatment unit 220 is arranged between the first light treatment units 210 in the longitudinal direction of the stent structure 100 . do. In addition, when viewed in a cross-section in the radial direction of the stent structure 100 , the second unit for phototherapy 220 is arranged between the first units for phototherapy 210 . According to this arrangement structure, even in the contracted state of the stent structure 100, the light source module of the second light treatment unit 220 between adjacent unit units of the first light treatment unit 210 irradiates light to the outside. It can be arranged so that

At this time, since the direction in which the light source of the light treatment unit 200 is irradiated should be toward the duodenal mucosa, the battery part of the light treatment unit 200 on the outer peripheral surface of the stent structure 100 is on the stent structure 100 . It may have an attached form, and on the inner peripheral surface of the stent structure 100 , the LED patch portion of the phototherapy unit 200 is coupled and attached from the inside of the stent structure 100 , so that the battery portion is the stent structure 100 of It can be seen that the internal through-hole direction is made.

Therefore, as shown in FIGS. 3 (a) and (b) and 4 (a) and (b), the LED patch-coupled stent 10 is the outer peripheral surface of the stent structure 100 in the cross-sectional structure before contraction. In having three lines, the stent structure 100 is formed to be spaced apart from each other by a predetermined interval in three lines on the inner peripheral surface. Here, when the unit for phototherapy 200 is contracted while holding both ends for the procedure, the unit for phototherapy 200 disposed on the outside and the inside of the stent structure 100 is flexibly narrowed while to form a constricted structure.

In addition, the stent structure 100 to which the phototherapy unit 200 is coupled takes a shape of about 2 cm to 3 cm of the outer diameter (D1) before contraction as shown in FIGS. 4 (a) and (b), and the length When the diameter is contracted by the force in the direction, the outer diameter D2 takes a shape of about 1 cm. According to this contractile structure, when a force pulling the stent 10 in the longitudinal direction is applied, the rhombus mesh shape of the stent structure 100 is elongated and the outer diameter of the stent structure 100 is reduced. It can be used for procedures, etc. For example, when the stent structure 100 to which the phototherapy unit 200 is coupled is inserted into the curved structure of the duodenum and the stent 10 in a contracted state is restored, expanded or expanded, the stent 10 is formed in the duodenum. It can be attached to the inner wall.

Referring to FIG. 5 , when the units for phototherapy 200 according to the present embodiment are arranged on the outside and the inside of the stent structure 100 , a link line for connecting each unit for phototherapy 200 to each other to provide The link line includes a first link line 230a and a second link line (refer to 230b of FIG. 2 ).

The link line includes a signal line for connecting the LED patch 210 included in the phototherapy unit 200 and a power line for connecting the power sources of the battery 220 included in the phototherapy unit 200 . It has a dual structure. In addition, the link line 230 may function as a mechanical connection means to maintain a predetermined interval between the units for phototherapy 200 arranged in the longitudinal direction when the stent structure 100 is contracted.

The first link line 230a and the second link line can be freely bent and unfolded such as meandering shape, zigzag shape, and wave shape to have a stretchable structure when the stent structure 100 contracts and expands. It is designed in a wavy form. The stent structure 100 extends in a straight line form as the link line is stretched when the outer diameter contracts and the length increases during contraction, and when expanded back to the original state, the length decreases as the outer diameter increases and the link wire has a meandering shape. can be configured.

In addition, since each of the LED patches 210 are connected to each other through a signal line included in the link line, for on/off control, dimming control, and light intensity control of the light source module 211 by the LED patch Each signal may be transmitted to another LED patch 210 , and operation control of the light source module 211 of the LED patch 210 connected as a whole may be performed.

In addition, by connecting a plurality of batteries 220 coupled to each LED patch 210 through a power line included in the link line, the plurality of batteries 220 can be connected in series, parallel, or series-parallel to be driven. Therefore, the battery power can be used more usefully.

Referring to FIG. 6 , the LED patch-coupled stent 10A according to the present embodiment includes a stent structure 100 and a unit 200 for phototherapy. The stent structure 100 is substantially the same as the stent structure of the embodiment described above with reference to FIGS. 1 to 5 except that it is formed by a double wire. And, the phototherapy unit 200 is substantially the same as the stent structure of the embodiment described above with reference to FIGS. 1 to 5 .

According to this embodiment, various shapes and modifications are possible in the stent structure 100 coupled with the unit 200 for phototherapy. However, when the stent structure is contracted before the contraction or when the outer diameter is reduced by pulling in the longitudinal direction, the phototherapy units arranged inside and outside of the stent structure 100 are arranged in a space complementary to each other so as to surround the stent structure In, for example, as long as it can be achieved to irradiate light in a uniform distribution to the inner wall of the duodenum, it is not particularly limited.

7 is a block diagram of a configuration of an LED patch that can be employed in the LED patch-coupled stent according to an embodiment of the present invention. FIG. 8 is a block diagram illustrating the LED patch of FIG. 7 .

7 and 8, the stent 10 according to the present embodiment, the LED patch 210 of the phototherapy unit 200, to function as an optical unit for photodynamic therapy, a flexible circuit board At least one light source module 211 mounted on the 210a to emit light, a power terminal 212 connected to the battery 218, and a regulator circuit 213 for supplying a constant voltage to each component. , and a booster circuit 214 for boosting a predetermined voltage supplied from the battery 218 . In addition, it may include a driving driver 215 for controlling the operation of the light source module. The driving driver 215 may include a regulator circuit 213 and a booster circuit 213 .

The circuit board 210a uses a flexible printed circuit board (FPCB) as a stretchable material having a predetermined elongation. For example, the circuit board may have a thickness of about 0.1 to 0.2 mm.

The LED patch 210 may have a stretchable patch structure capable of maintaining a stable power supply and a bonding state of a circuit configuration even if the shape is changed, so that it can be freely bent or stretched.

The light source module 211 is formed in a form in which an LED (Light Emitting Diode) emitting light is mounted in a plurality of arrays. As an embodiment, in the form of an array formed in 4 horizontally and 5 vertically, LEDs may be mounted.

The LED may have a rated voltage of 2V, and an ultra-small LED having a uniform brightness and a size of 100 to 300 micrometers (um) may be used.

The light source module 211 in the form of an array is formed at three points positioned at equal intervals in one LED patch. That is, three light source modules 211 may be arranged at the same interval in one LED patch.

In the LED patch-coupled stent according to this embodiment, light sources by three light source modules 211 may be emitted on one unit for phototherapy 200 , and the unit for phototherapy 200 is connected and arranged. 36 light sources may be provided by a 3x4x3 light source array on the outside of the structure 100, and 27 light sources are provided on the inside by a 3x3x3 light source array, so that 63 light sources are evenly arranged at equal intervals in total. And, thereby, it is possible to perform a relatively uniform light irradiation to the outside of the stent.

In addition, at least any one or more of the LED patches according to this embodiment includes a Bluetooth chip capable of BLE (Bluetooth Low Energy) communication to be controlled using an application installed in a smartphone having a Bluetooth function or a corresponding external communication device. It may further include a Bluetooth circuit 226 .

The LED patch including the Bluetooth circuit 226 may be referred to as a first patch, and the LED patch not including the Bluetooth circuit may be referred to as a second patch.

Therefore, it is necessary to design a Bluetooth antenna circuit 227 for Bluetooth communication in the first patch. At this time, the antenna 227 may be designed and built in the form of being inserted into the substrate of the circuit board.

An antenna for Bluetooth communication may be an antenna of a 2.4 GHz ISM (Industry-Science-Medical) band, and the Bluetooth antenna to which this ISM band is applied has a certain thickness. In the present invention, the thickness of such an antenna is minimized to do it For example, when a general Bluetooth antenna has a thickness of 2mm, the thickness of the LED patch can be further reduced by inserting it to overlap the thickness of the circuit board and embedding it.

Since the Bluetooth circuit 226 and the built-in antenna 227 are designed in an extra space of the first patch, the size of each LED patch is the same.

The first patch may receive an on/off control signal for the light source module 211 transmitted from a smart phone or a corresponding external communication device through Bluetooth communication. The driving driver 225 provided in the first patch serves to control the operation of the light source module 221 of the unit 200 for phototherapy, such as on/off.

In addition, the device of this embodiment may further include another second patch having a configuration similar to that of the first patch. In that case, by dividing the unit of the number of LED patches connected to the first patch and the second patch, and performing divisional control of the light source module connected to the first patch and the second patch, partial light irradiation It can be implemented to minimize the induction of pain through the

And the phototherapy unit 200 is made by combining the battery 220 stacked while being superimposed on the same area as the LED patch on the opposite side of the surface on which light is emitted from the light source module 211 of the LED patch 210 .

The battery 220 may be referred to as a thin film battery that can be applied to a curved surface having a curvature of a certain radius as it has a flexible characteristic. For example, a thin film battery having a thickness of 0.3 to 0.4 mm may be applied to the battery.

The battery 220 may be a single thin film cell in one form may be stacked on an LED patch, and a battery 220 in the form of arranging small thin film cells having a predetermined number horizontally and vertically in an array form. may be laminated on the LED patch 210 .

In addition, the phototherapy unit 200 stacked on the inside and outside of the above-described stent structure 100 may be formed and integrated with a film through an encapsulation process wrapped with transparent flexible silicone harmless to the human body.

Due to the transparent silicone coating film formed on the outside of the phototherapy unit 200, the light from the light source modules arranged at regular intervals in a transparent state can be smoothly irradiated to the mucous membrane of the duodenum, and the phototherapy unit 200 It can be driven while protecting the electric motor while minimizing the contact effect on the human body due to electrical operation.

Figure 9 is an exemplary view of the use state of the LED patch-coupled stent according to an embodiment of the present invention. 10 and 11 are graphs of results obtained in a diabetic animal model experiment using the LED patch-coupled stent according to an embodiment of the present invention.

Referring to FIG. 9 , the LED patch-coupled stent 10 according to the present embodiment may perform light irradiation toward the mucous membrane of the inner wall of the duodenum through the light source module 211 . According to such light irradiation, pathological cell death of the mucosal layer, induction of metabolic improvement through normal mucosal regeneration, and minimization of duodenal stenosis using low-temperature ablation (LTA) of LEDs can have an effect.

In particular, when light is irradiated to the pancreas for 22 seconds using the low energy of LED, for example, with an output of 40 mW/cm 2 per unit area (cm 2 ), it improves pancreatic regeneration and hepatic glucose synthesis and carbohydrate metabolism in diabetic animal models. It was confirmed through an experiment that it has a blood sugar lowering effect.

That is, as shown in FIGS. 10 and 11 , after a certain time (minutes, minutes) has elapsed after the stent procedure, the test subject's blood sugar (Glucose) was monitored, and as a result, the normal group (CG), the diabetic group (DC) and the insulin treatment group Among the (DLED), when the blood sugar of the diabetic group (DC) was compared with the maximum after the operation, it can be seen that the blood sugar concentration dropped by 200 (mg/dL) 120 minutes after the operation.

As a result of comparing the incremental area under the curve (AUC) of the intraperitoneal glucose tolerance test (IPGTT), which is a blood sugar-related functional test, the blood sugar lowering effect can be seen from the difference in the area of the graph between 0-120 minutes. ), it can be seen that the performance is excellent.

As described above, in the detailed description of the present invention, preferred embodiments have been described, but those of ordinary skill in the art can present the present invention within the scope that does not depart from the spirit and scope of the present invention as set forth in the claims. It will be understood that various modifications and changes are possible.

[Explanation of code]

10: LED patch-coupled stent

100: stent structure 200: unit for light therapy

210: LED patch 211: light source module

222: power terminal 223: regulator circuit

224: booster circuit 225: driving driver

226: bluetooth circuit 227: antenna

220: battery 230: link wire

Claims

A duodenal implantable stent structure having a mesh structure, and

It consists of a light treatment unit formed by combining an LED patch having a light source module for irradiating light toward the mucous membrane of the duodenum and a battery stacked while being superimposed on the LED patch,

LED patch-coupled stent, characterized in that the phototherapy unit is configured to be connected to each other while one or more arranged inside and outside the stent structure.
The method according to claim 1,

The LED patch is one or more light source modules that form an array of LEDs for emitting light on a flexible circuit board having a predetermined elongation,

power terminal connected to the battery;

A regulator circuit to maintain and supply a constant voltage,

a booster circuit for boosting a constant voltage supplied from the battery; and

LED patch-coupled stent, characterized in that it comprises a driving driver for controlling the operation of the light source module.
3. The method according to claim 2,

Any one of the LED patch further comprises a Bluetooth circuit including a Bluetooth chip and a Bluetooth antenna, the LED patch characterized in that it is controlled using an application installed in a smartphone having a Bluetooth function or a corresponding external communication device. Combined stent.
4. The method according to claim 3,

The antenna is inserted into the thickness of the circuit board, characterized in that the LED patch-coupled stent made of a built-in type.
The method according to claim 1,

The light treatment unit is connected to a certain number at regular intervals at each location divided at 120 degrees along the outer peripheral surface of the stent structure and arranged in a line, and the light disposed on the outer peripheral surface along the inner peripheral surface of the stent structure LED patch-coupled type, characterized in that a certain number is connected and arranged at regular intervals in a line for each position separated at an angle of 120 degrees so as to deviate from the arrangement of the treatment unit, so that the LED light is irradiated in all directions outside the stent stent.
6. The method of claim 5,

The phototherapy unit is provided with a link line for connecting them to each other, and the link line is designed in a wavy shape so that the stent structure is stretched while being contracted and returned to its original state when the stent structure is expanded. LED patch-coupled stent, characterized in that made.
7. The method of claim 6,

The link line is an LED patch-coupled stent, characterized in that it has a dual structure including a signal line for connecting the LED patch included in the phototherapy unit and a power line for connecting the power sources of the battery.
8. The method of claim 7,

An LED characterized in that the on/off control signal of the light source module is transmitted to another LED patch through the signal line, thereby performing on/off of the light source module of the LED patch connected as a whole. Patch-coupled stents.
8. The method of claim 7,

As the batteries are connected to each other through the power line, the LED patch-coupled stent, characterized in that the connected batteries are driven in either series or parallel.
The method according to claim 1,

The stent structure is an LED patch-coupled stent, characterized in that by connecting a single wire made of an expandable alloy, or by weaving or crossing a plurality of wires to form a rhombus-shaped mesh structure.
The method according to claim 1,

LED patch-coupled stent, characterized in that the phototherapy unit stacked inside and outside the stent structure is protected by forming a film through an encapsulation process wrapped with transparent flexible silicone.