KR102204345B1 - Composition for improving optical characteristic of skin comprising optical clearing agents - Google Patents

Abstract

The present invention relates to a composition for improving optical properties comprising a light scattering reducing material.
The present invention uses a light-scattering-reducing substance in cosmetics to infiltrate the light-scattering-reducing substance between keratinocytes to reduce crystallization of constituents, correct light scattering due to the diversity of skin or keratin constituents, and reduce water evaporation to appear in the stratum corneum. It can improve the dullness of the skin by suppressing the change in light properties.

Description

Composition for improving optical characteristics, including a light scattering reducing material, comprising optical clearing agents

The present invention relates to a composition for improving optical properties that improves changes in skin light properties, changes in skin tone such as dullness, and the like that occur according to the progress of keratinization by applying a light scattering reducing substance to the skin.

Keratin is formed by going through a process of differentiation of epidermal cells called turn over, in which keratinocytes existing under the epidermis move to the stratum corneum and differentiate into keratin cells. As the skin cells that were transparent lose moisture during the differentiation process, the cellular components crystallize, and as melanin pigments get closer to the skin surface, they lose moisture and are oxidized, making the stratum corneum opaque and looking for light and look dull. Therefore, there are a concept product that induces dead skin cell dropout to occur in accordance with the turnover period (28 days), a product or procedure that removes the outermost dead skin cell by forcibly peeling it, but in the former case, it is necessary to continuously manage the effect. It can be obtained, and in the latter case, there is an effect of temporarily clearing the skin, but there is a disadvantage that the skin irritation is strong and the transparency of the keratin cannot be fundamentally controlled. Because of the advantages that can be obtained through keratin management (ie, it can improve skin color and look transparent) while accepting the above inconvenience, many people have been continuously taking care of the skin in the same way as above. In addition, recently, research is being conducted to form a thin film with moisture using oil to correct light scattering of the skin, but it is a temporary method and it is not easy to realize natural images.

The living tissue is composed of various materials such as collagen, elastic fibers, cells, and extracellular matrix (ECM). Since these components have different refractive indices, they vary depending on the type of tissue, the degree of dehydration of the cells, and the ratio of the components, but it is inevitable that light scattering of the skin tissue occurs. Therefore, optical clearing agents (OCA), such as glycerin, glucose, polyethylene glycol, and dimethyl sulfoxide oleic acid, have been used to increase light transmittance because it is essential for clear and clear analysis of biological tissues through a microscope. .

G. Vargas reported that the application of glycerol to the skin or injection into the skin helps to analyze blood vessels in the skin. In addition, H. Hiroshi of Riken Research Institute in Japan succeeded in processing 4M of urea and clearing the mouse brain, and K. Meng-Tsen of the same laboratory also made the mouse brain transparent by using a fructose solution of 80% or more. I have contributed to the research. In general, OCA is known to adjust the refractive index consistently due to dehydration of ECM, substitution due to absorption of light scattering reducing substances between tissue cells, and structural changes of collagen, but a clear mechanism has not yet been identified.

Since optics focuses on analyzing and diagnosing blood vessels in tissues or treating tattoos and pigmentation in the skin by using lasers, research is mainly being conducted to increase the transparency of tissues by delivering OCA to deep areas in tissues. For example, by overcoming the skin barrier role of the epidermis (stratum corneum) through various methods such as a method of directly injecting OCA into the dermis layer, a method of increasing penetration by damaging or removing the epidermis, and delivering OCA to the dermal layer using ultrasound A method to induce the transparency of the product is being studied. However, since side effects of skin irritation, erythema, and even necrosis have been reported when OCA is injected into the human body or effective absorption is induced, the method generally used for optical measurement is difficult to apply to transparent stratum corneum.

As mentioned earlier, the underlying cause of the stratum corneum becoming opaque and dull is due to the crystallization of cellular components and oxidation of pigments due to the reduction of moisture in the keratin, so OCA permeates between the keratinocytes to reduce component crystallization and reduce the diversity of skin components. If we can correct light scattering caused by and prevent water evaporation, it is expected that we can develop cosmetics that can improve the dullness of the skin by fundamentally preventing the color change that appears in the stratum corneum.

Republic of Korea Patent Publication No. 10-2011-0111968

G. Vargas, Laser Sur. Med. 1999, vol. 24, pp.133 G. Vargas, Photochem. Photobiol. 2003, vol.77(5), pp.541 H. Hiroshi, Nat. Neurosci. 2011, vol. 14(11), pp.1481 K. Meng-Tsen, Nat. Neurosci. 2013, vol.16(8), pp.1154

It is an object of the present invention to use a light scattering reducing material (optical clearing agent) in a cosmetic composition to improve the change in the light characteristics of the skin, changes in skin tone such as dullness, etc. It is to provide an external preparation.

As a means for solving the above problems, the present invention comprises a light scattering reducing material of 5% by weight or more and less than 40% by weight based on the total weight of the composition, and the light scattering reducing material is glycerin, fructose, urea, thiazone , Glucose, benzylalcohol-benzoate, polypropylene glycol, polyethylene glycol, dimethyl sulfoxide, and at least one selected from the group consisting of oleic acid It provides a cosmetic composition for improving properties.

The present invention also includes a light-scattering reducing material of 5% by weight or more and less than 40% by weight of the total weight of the external preparation for skin, and the light-scattering reducing material is glycerin, fructose, urea, thiazone, glucose, benzyl alcohol-benzo Provides skin external preparations for improving optical properties, one or more selected from the group consisting of Benzylalcohol-benzoate, Polypropylene glycol, Polyethylene glycol, Dimethyl sufoxide and Oleic acid do.

The present invention uses a light-scattering-reducing substance in cosmetics to infiltrate the light-scattering-reducing substance between keratinocytes to reduce crystallization of constituents, correct light scattering due to the diversity of skin or keratin constituents, and reduce water evaporation to appear in the stratum corneum. It can improve the dullness of the skin by suppressing the change in light properties.

1 is a result of confirming the transparency of the skin by treating each concentration of fructose and urea as a material for reducing light scattering on pig skin.
Figure 2 is a result of confirming the transparency of the skin by treating each concentration of fructose and urea as a light scattering reducing material in the stratum corneum peeled off with a keratin tape.
3 is a result of confirming the transparency of the skin by treating the pig epidermis with 40% fructose and 40% urea as a light scattering reducing material.
Figure 4 is a result of confirming the transparency of the skin by treating a solution of distilled water, 5% fructose/5% urea, 10% fructose/10% urea, and 20% fructose/20% urea composition on pig skin.
5 is a result of confirming the transparency of the skin by treating pig skin with a solution of distilled water, 25% glucam, 25% glucam/10% glycerol, 50% glucam, and 5% fructose/5% urea. to be.
Figure 6 is a skin by treating a solution of the composition of distilled water, 5% fructose/5% urea/5% glycerol, 5% fructose/5% urea, 5% fructose/5% urea/5% glucam on pig epidermis. This is the result of checking the transparency of.

Hereinafter, the configuration of the present invention will be described in detail.

The present invention includes 5% by weight or more and less than 40% by weight of a light scattering reducing material based on the total weight of the composition, and the light scattering reducing material is glycerin, fructose, urea, thiazone, glucose, benzyl alcohol-benzoate ( Benzylalcohol-benzoate), polypropylene glycol, polyethylene glycol, dimethyl sulfoxide, and oleic acid.

The present invention uses a light-scattering reducing substance used to increase light transmittance in optics in cosmetics, and is evenly delivered to the stratum corneum, the outermost layer of the skin, to reduce crystallization of components, and to correct light scattering due to diversity of skin or stratum corneum components. , It is characterized in that it can improve the dullness of the skin by reducing the evaporation of moisture, thereby suppressing the change in the optical properties appearing in the stratum corneum.

Accordingly, the light scattering reducing material may be included in an amount of 5% by weight or more and less than 40% by weight, more specifically, 10 to 20% by weight, based on the total weight of the cosmetic composition. If the range is less than 5% by weight, the effect of improving the optical properties of the skin is insufficient, and if the range is more than 40% by weight, the skin may become hard and deformed, and the skin may become too transparent, which may harm natural skin gloss.

The light scattering reducing substances include glycerin, fructose, urea, thiazone, glucose, benzylalcohol-benzoate, polypropylene glycol, polyethylene glycol, dimethyl sulfoxide ( Dimethyl sufoxide) or oleic acid may be used. More specifically, the light scattering reducing material may be a mixture of urea and fructose. The urea and fructose mixture may be mixed at the same weight ratio.

When the light scattering reducing substance is used in cosmetics, the cosmetic manufactured by containing the light scattering reducing substance as an active ingredient may be prepared in the form of a general emulsified formulation or a solubilizing formulation. For example, a lotion such as a flexible lotion or a nutritional lotion; Emulsions such as facial lotion or body lotion; Creams such as nourishing cream, moisture cream, or eye cream; Body essence; Cosmetic ointment; spray; Gel; pack; Sunscreen; Makeup base; Foundations such as liquid type, solid type or spray type; powder; Makeup removers such as cleansing cream, cleansing lotion, and cleansing oil; It may have a formulation such as a cleaning agent such as a cleansing foam, soap, and body wash.

In addition, the cosmetics include fatty substances, organic solvents, solubilizers, thickeners, gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, in addition to the light scattering reducing substances. Commonly used in cosmetic fields such as ionic emulsifiers, nonionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic activators, lipophilic activators or lipid vesicles. It may contain auxiliaries used.

The present invention can also be provided as a formulation of a skin external preparation for improving optical properties by including a light scattering reducing substance as an active ingredient.

When the light scattering reducing substance is used for external skin preparation, additionally fatty substances, organic solvents, solubilizers, thickening and gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, Water, ionic emulsifiers, nonionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic activators, lipophilic activators or lipid vesicles, etc. It may contain adjuvants commonly used in the field of dermatology, such as any other ingredients commonly used. In addition, the above ingredients may be introduced in amounts generally used in the field of dermatology.

When the light scattering reducing substance is provided as an external preparation for skin, it is not limited thereto, but may be a formulation such as an ointment, patch, gel, cream, or spray.

Hereinafter, the present invention will be described in detail by examples. However, the following examples are only illustrative of the present invention, and the contents of the present invention are not limited to the following examples.

<Example 1>

Distilled water, 10% glycerol solution, 2 products of LG Household & Health Care Co., Ltd.(Product 1: Gel cream type, Product 2: Oil type), 4 types to confirm that the skin becomes transparent when actually immersed in the prepared solution. Pig skin with a thickness of 700 µm was immersed in fructose solution (10 to 80%) and 3 types of urea solution (10 to 40%). Each skin sample was cleaned after 30 minutes and placed on a grid paper to visually check the transparency of the skin to take a picture and analyze it.

As shown in Fig. 1, there was little difference between the untreated sample (No Treatment, NT) and the sample dipped in distilled water, and when applied to two products of 10% glycerol and LG Household & Health Care, there were only slight improvements. There was no big difference. However, when immersed in a solution of fructose and urea, it was confirmed that the transparency of the skin increased significantly as the concentration increased.

<Example 2>

In order to confirm the effect of the prepared solution on the keratin, a keratin tape was applied to the skin, and then removed and covered with keratin. Thereafter, the same composition as in Example 1, that is, distilled water, 10% glycerol solution, two products of LG Household & Health Care Co., Ltd., four kinds (10 ~ 80%) of fructose solution, three kinds (10 ~ 40%) Each of the urea solution was added dropwise to the stratum corneum layer on the keratin tape. After 4 hours, each solution and formulation were washed with water and dried, and then placed on black paper to observe that the keratin of the keratin tape became transparent, and photographed and analyzed.

As shown in Fig. 2, there was almost no difference between the sample without any treatment (No Treatment, NT) and the sample with distilled water, and even when using two products of 10% glycerol and LG Household & Health Care Co., Ltd., keratin on the tape Had little effect on. However, when the fructose and urea solutions were dropped, it was confirmed that the transparency of the keratin on the keratin tape increased significantly as the concentration increased.

<Example 3>

In order to check the effect on the transparency when the prepared solution is applied to the skin epidermis, the concentration that is effective for keratin clearing in each solution composition, i.e., distilled water and LG Household & Health Care's product 2 (oil type formulation) as a control, 40% of fructose and 40% of urea were applied to pig skin of 700 μm in thickness, respectively, and stored for 8 hours at room temperature and humidity conditions. Thereafter, the pig skin was washed clean with running water, and then placed on a grid paper to visually check the transparency of the skin, and a picture was taken and analyzed.

As shown in FIG. 3, there was almost no difference between the sample coated with distilled water and the sample coated with the oil-type company product, but when the fructose and urea solution were dropped, it was confirmed that the transparency of pig skin increased.

<Example 4>

To confirm that the skin becomes transparent according to the composition of fructose and urea, a solution was prepared in the composition of distilled water, 5% fructose/5% urea, 10% fructose/10% urea, and 20% fructose/20% urea. Pig skins each having a thickness of 700 μm were immersed. Each skin sample was washed off after 30 minutes and placed on a grid paper to visually check the transparency of the skin to take a picture and analyze it.

As shown in FIG. 4, there was almost no difference between the sample that was not treated (No Treatment, NT) and the sample dipped in distilled water, and it was confirmed that the transparency of the skin increased significantly as the concentration of OCA increased. However, if the concentration is too high, the skin becomes rather hard and deforms, so up to 10% fructose/10% urea seems to be suitable.

<Example 5>

Distilled water, 25% glucam, 25% glucam/10% to confirm that the skin becomes transparent according to the composition of glucam-E20 to ensure that all humectants used in cosmetics play the role of OCA. A solution was prepared with a composition of glycerol, 50% glucam, and 5% fructose/5% urea, and each of pig skin having a thickness of 700 μm was immersed. Each skin sample was cleaned after 30 minutes and placed on a grid paper to visually check the transparency of the skin to take a picture and analyze it.

As shown in Figure 5, when the concentration of glucam-E20 is used at a high concentration of 25%, it affects the clarity of the skin. Compared to that, the transparency of the skin was not excellent. Therefore, it is believed that not all types of moisturizers play a role in OCA.

<Example 6>

To determine the effect of the composition of fructose and urea on the clarity of the skin when applied to the skin epidermis depending on the presence or absence of glycerol and glucam, distilled water, 5% fructose/5% urea/5% glycerol, 5% fructose A solution was prepared in the composition of /5% urea, 5% fructose/5% urea/5% glucam, applied to pig skin of 700 µm in thickness, and stored for 8 hours at room temperature and humidity conditions. Thereafter, the pig skin was washed clean with running water, and then placed on a grid paper to visually check the transparency of the skin, and a picture was taken and analyzed.

When using the composition of 5% fructose / 5% urea as shown in Figure 6, it was confirmed that the most affected the transparency of the skin.

<Formulation Example 1> Cream (100g)

OCA was added to purified water, followed by heating and adjustment at 70°C. After heating and dissolving the dairy components, an emulsifier, a preservative, and the like were added and adjusted to 70°C. This was added to the previous aqueous phase, and the emulsified particles were homogenized with a homomixer, followed by degassing, filtering, and cooling.

Main ingredient (OCA) Fructose 10 g Urea 10 g Dairy component Serostearyl Alcohol 6.0 g Stearic acid 2.0 g lanolin 4.0 g Squalane 9.0 g Octyldodecanol 10.0 g Moisturizer 1,3-butylene glycol 3.0 g glycerin 2.0 g Emulsifier POE (25) Cetyl Alcohol Ether 2.0 g Glycerin monostearate 2.0 g Fragrance and preservatives Appropriate amount Purified water Balance

<Formulation Example 2> Lotion agent (100g)

OCA was added to purified water, followed by heating and adjusting to 70°C. After heating and dissolving the dairy components, an emulsifier, a preservative, and the like were added and adjusted to 70°C. This was added to the previous aqueous phase, emulsified with a homomixer, and then an aqueous solution of hyaluronic acid 1 was added and homogeneously mixed with a homomixer, followed by degassing, filtering, and cooling.

Main ingredient (OCA) Fructose 10 g Urea 10 g Dairy component Serostearyl Alcohol 1.0 g Beeswax 0.5 g Vaseline 2.0 g Squalane 6.0 g Dimethylrolysiloxane 2.0 g Moisturizer 1,3-butylene glycol 4.0 g glycerin 4.0 g Emulsifier POE (10) monooleic acid ester 1.0 g Glycerol monostearic acid ester 2.0 g Fragrance and preservatives Appropriate amount Purified water Balance

<Formulation Example 3> Gel (100g)

Polyethylene glycol was added to purified water to dissolve, and OCA was added to dissolve by heating. This was cooled to about 50° C., polyoxyethylene cetyl ether was added to propylene glycol and glycerin while stirring, and then heated to about 50° C. was added. Further, sodium hydroxide was added while stirring continuously, and the pH was adjusted to about 6.8. After cooling to about 40°C, isopropanol was added, and after cooling to about 25°C, it was collected in a suitable container.

ingredient content Fructose 10 g Urea 10 g Polyethylene glycol 8.0 g Carboxyvinyl polymer 0.5 g Methyl cellulose 0.2 g Propylene glycol 5.0 g glycerin 2.0 g Polyoxyethyleneoleylcetyl ether 1.0 g Isopropanol 5.0 g Sodium hydroxide Appropriate amount Purified water Balance

<Formulation Example 4> Nourishing Cream (100g)

It was prepared in the same manner as in Formulation Example 1 using the following components.

ingredient content Fructose 10 g Urea 10 g Stearyl alcohol 6.0 g Stearic acid 2.0 g Concentrated glycerin 1.0 g Squalane 9.0 g 1, 3-butylene glycol 6.0 g Polysorbate 60 1.5 g Polyethylene glycol 1000 4.0 g Hardened lanolin 4.0 g Octyl dodecanol 10.0 g Sorbitan Stearate 0.8 g Triethanolamine 0.5 g Preservatives and flavorings Appropriate amount Purified water Balance

Claims (10)

Including 10% by weight or more to less than 40% by weight of a light scattering reducing material (optical clearing agent) with respect to the total weight of the composition,
The light scattering reducing material is a cosmetic composition for improving optical properties of a mixture of urea and fructose.
The method of claim 1,
The light scattering reducing material is a cosmetic composition for improving optical properties containing 10 to 20% by weight based on the total weight of the composition.
delete The method of claim 1,
A cosmetic composition for improving optical properties, wherein a mixture of urea and fructose is mixed in the same weight ratio.
The method of claim 1,
Cosmetic compositions for improving light properties include softening lotion, astringent lotion, lotion, essence, eye cream, eye essence, oil serum, serum, cleansing cream, cleansing foam, cleansing water, pack, gel, body lotion, body oil and A cosmetic composition for improving optical properties that is formulated in any one of the body essences.
Including a light scattering reducing material (optical clearing agent) of 10% by weight or more to less than 40% by weight based on the total weight of the external preparation for skin,
The light scattering reducing material is a mixture of urea and fructose, a skin external preparation for improving optical properties.
The method of claim 6,
The light scattering reducing material is a skin external preparation for improving optical properties, which is included in an amount of 10 to 20% by weight based on the total weight of the external preparation for skin.
delete The method of claim 6,
A mixture of urea and fructose is a mixture of the same amount by weight.
The method of claim 6,
The skin external preparation for improving optical properties is formulated in the form of an ointment, patch, gel, cream or spray.

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