KR102152646B1 - Quantitative analytic method for antimon or cadmium - Google Patents

Abstract

The present invention comprises the steps of preparing a nitric acid solution which is a blank liquid standard sample; Adding antimony or cadmium to the nitric acid solution to prepare a liquid standard sample of two or more concentrations having different concentrations; Selecting an interference element whose energy value is within the range of the detected energy value of antimony or cadmium from among the detected winsos by irradiating X-rays on the analysis sample; Deconvolution of correcting the detection energy peak of antimony or cadmium from the detected energy peak of the overlapping interference element among the energy peaks detected by irradiating X-rays to the liquid standard sample for each concentration in the step of selecting the interference element ( deconvolution) step; Preparing a standard calibration curve by performing the deconvolution step after irradiating each of the prepared liquid standard samples for each concentration with X-rays; And measuring the concentration of antimony or cadmium in the analysis sample according to a standard calibration method using a standard calibration curve prepared by irradiating X-rays on the analysis sample to detect the energy peak, and then measuring the detected energy peak value by a standard calibration curve. It relates to a method for quantitative analysis of cadmium.

Description

Quantitative analysis method of antimony or cadmium {QUANTITATIVE ANALYTIC METHOD FOR ANTIMON OR CADMIUM}

The present invention relates to a method for quantitative analysis of antimony or cadmium.

In recent years, as the strong toxicity of compounds containing heavy metals and their accumulation in the internal organs, it is the result of research that causes various fatal diseases, there is an active movement to regulate the use of heavy metals.

Trace amounts of heavy metals contained in cosmetics are free from the raw materials used, and if they are in trace amounts that do not harm human safety, heavy metals such as lead, arsenic, antimony, cadmium, mercury, cobalt and nickel If it is contained in an excessive amount, it may cause serious diseases such as skin troubles.

Lead, arsenic, mercury, antimony, and cadmium regulate the amount that can be used in cosmetics, but there are no special restrictions on other heavy metals. However, the incidence rate of allergy caused by heavy metals such as nickel and cobalt is gradually increasing, and the amount of use thereof is gradually limited.

Magnesium, copper, iron, and zinc have been approved for use in cosmetics because of their safety to the human body according to their oxidation state or molecular structure, but the use of such heavy metals is also regulated for products that can be inhaled to the human body through the oral cavity.

Through the above research reports on allergy and toxicity of heavy metals, consumers are demanding safer products, so it is urgently necessary to secure the safety of heavy metals in cosmetics.

However, it is known that it is difficult in the field of analysis to analyze heavy metals dissolved in complex matrices such as cosmetics, and there are atomic absorption spectrometer (AAS) and inductively coupled plasma (ICP), but pretreatment Since it takes a long time and uses a strong acid such as hydrofluoric acid, its use is limited as it is an inappropriate method for the purpose of quality control of raw materials and products.

Patents that analyze heavy metals using X-Ray Fluorescence (XRF) have already been reported, but these technologies do not mention technology for standard sample preparation or matrix correction. Likewise, when applied to cosmetics of complex matrix containing organic substances and various inorganic metals, accurate analysis was difficult due to the error due to the difference in the matrix and the measurement error due to the interference phenomenon, and it was impossible to perform a small quantity quantitative analysis.

International Patent Publication WO 2010/023684 A2 (2010.03.04.)

Therefore, the present inventors developed a pretreatment method for cosmetic analysis samples to have a matrix similar to a standard sample, and a simple quantitative analysis that can accurately analyze antimony or cadmium, which are heavy metals present in trace amounts in various types of samples, by X-ray fluorescence analysis. Completed the method.

Accordingly, an object of the present invention is to provide an optimal X-ray fluorescence analysis method capable of simple, rapid and accurate analysis of antimony or cadmium present in trace amounts in a liquid sample.

The present invention comprises the steps of preparing a nitric acid solution which is a blank liquid standard sample;

Adding antimony or cadmium to the nitric acid solution to prepare a liquid standard sample of two or more concentrations having different concentrations;

Selecting an interference element in which an X-ray spectrum and an energy level overlapped when X-rays are irradiated to antimony or cadmium among the detected winsos by irradiating X-rays on the analysis sample;

Deconvolution of correcting the detection energy peak of antimony or cadmium from the detected energy peak of the overlapping interference element among the energy peaks detected by irradiating X-rays to the liquid standard sample for each concentration in the step of selecting the interference element ( deconvolution) step;

Preparing a standard calibration curve by performing the deconvolution step after irradiating each of the prepared liquid standard samples for each concentration with X-rays; And

After detecting the energy peak by irradiating X-rays on the analysis sample, measuring the concentration of antimony or cadmium in the analysis sample according to a standard calibration method using a standard calibration curve prepared for the detected energy peak value; Provides a quantitative analysis method of

The quantitative analysis method of antimony or cadmium according to the present invention does not require pretreatment for a sample, so analysis can be performed simply and quickly, and the calibration curve method by preparing a standard sample, selection of an optimum target, and removal of the influence by interference elements Heavy metals can be accurately analyzed. In addition, since it is possible to simultaneously analyze various harmful elements that should not be contained in cosmetics other than antimony and cadmium, it can be effectively applied as a quality evaluation method to provide better products to consumers.

1 shows an X-ray spectrum measured by irradiating X-rays on a liquid standard sample according to the concentration of antimony and cadmium. The X-axis on the spectrum is the energy level (keV), and the Y-axis is the energy intensity. The K-alpha energy level of antimony is 26.355 keV, and the K-alpha energy level of cadmium is 23.170 keV.
Figure 2 shows a standard calibration curve of antimony according to the step of preparing the standard calibration curve of the present invention. The X-axis represents the concentration (ppm) calculated arithmetically based on the amount of antimony added to the standard sample of antimony, and the Y-axis represents the concentration of antimony in the standard sample calculated according to the step of correcting the absorption effect of the interference element of the present invention (ppm ).
Figure 3 shows a standard calibration curve of cadmium according to the step of preparing the standard calibration curve of the present invention. The X axis represents the concentration (ppm) calculated arithmetically based on the amount of cadmium added to the standard sample of cadmium, and the Y axis represents the concentration of cadmium in the standard sample calculated according to the step of correcting the absorption effect of the interference element of the present invention. ).
4 shows an X-ray spectrum corrected according to the step of correcting the absorption effect of interference elements by irradiating X-rays on a cosmetic liquid raw material. The X-axis on the spectrum is the energy level (keV), and the Y-axis is the energy intensity.

In the present specification, "Antimon" is an element symbol Sb, and means a Group 15 metalloid having an atomic number of 51.

In the present specification, "Cadmium" has an element symbol Cd, and means a Group 12 transition metal having an atomic number of 48.

All steps of the method for quantitative analysis of antimony and cadmium according to the present invention are selectively and independently performed with respect to antimony or cadmium, and in the quantitative analysis of antimony, cadmium-related steps are not performed, and antimony in quantitative analysis of cadmium The steps on are not performed.

In the present specification, the "analysis sample" refers to a sample obtained by collecting a certain amount of the substance to measure the concentration of antimony or cadmium in the substance to be analyzed.

In the present specification, the "blank sample" refers to a sample to which antimony or cadmium is not added.

In the present specification, the "standard sample" refers to a sample capable of arithmetically calculating the concentration of antimony or cadmium by adding a quantitative amount of antimony or cadmium to a blank sample.

In the present specification, the "standard sample by concentration" refers to two or more standard samples having different concentrations of antimony or cadmium.

In the present specification, "energy peak" means a value of an energy intensity for an energy level of an X-ray spectrum detected when a sample is irradiated with X-rays.

In the present specification, the "standard calibration curve" refers to a two-dimensional relationship between the concentration value calculated arithmetically for the standard sample for each concentration and the intensity value of the energy peak for the energy level of antimony or cadmium detected by irradiating X-rays. It means, and it can be calculated by approximating it in the form of a linear or a curve.

According to an exemplary embodiment of the present invention, the deconvolution step is an interference element absorption for removing an energy intensity value corresponding to an energy level range in which the detected energy peak of the detected antimony or cadmium and the energy peak of the selected interference element overlap. It further includes a step of correcting an absorption effect.

In the step of correcting the absorption effect of the interference element, the energy value measured by irradiating the sample with X-rays is deformed due to elements other than antimony or cadmium, thereby affecting the measurement of the concentration of antimony or cadmium in the sample. ) Is corrected so that the analysis method of the present invention can accurately measure the concentration value of antimony or cadmium in the sample.

According to an exemplary embodiment of the present invention, the step of correcting the absorption effect of the interference element further comprises correcting the detection energy peak of antimony or cadmium using a Lucas-Tooth/Price algorithm. Include.

According to an exemplary embodiment of the present invention, the step of correcting the detection energy peak of antimony or cadmium by the Lucas-Tooth/Price algorithm further includes correcting the detection energy peak of antimony or cadmium according to Equation 1 below.

[Equation 1]

In Equation 1, i is antimony or cadmium, j is an element other than antimony or cadmium, W _i is the mass-based concentration of antimony or cadmium in the sample, I _i is the intensity of the energy peak of antimony or cadmium, and I _j is antimony or Intensity of the energy peak of elements other than cadmium, k _i is the proportionality constant of the mass-based concentration value to the detection energy intensity of antimony or cadmium, and a _ij is the detection energy peak of the interfering element with respect to the detection energy peak of antimony or cadmium. The absorption effect (absorption effect) means a correction constant, and B _i means a background constant when the concentration of antimony or cadmium is 0.

According to an exemplary embodiment of the present invention, B _i , k _i , a _ij of Equation 1 are determined by the linear-squares method of detection energy peak values of two or more concentration-specific liquid standard samples.

The nitric acid solution, which is a blank liquid standard sample of the present invention, does not contain antimony or cadmium to be analyzed, and does not contain elements having energy levels near each energy level of antimony or cadmium. It does not cause interference in the process, so it is suitable as a blank sample.

According to an exemplary embodiment of the present invention, in preparing the liquid standard sample and preparing the liquid standard sample for each concentration, the concentration of the nitric acid solution is 5 to 10%. If the concentration of the nitric acid solution is less than 5%, antimony or cadmium may not be dissolved, and if the concentration of the nitric acid solution is more than 10%, the material of the container containing the sample or the film coated on the container surface may be dissolved, which is not suitable.

According to an exemplary embodiment of the present invention, in the deconvolution step and the step of measuring the concentration of antimony or cadmium in the sample to be analyzed, the energy peak is detected by X-ray fluorescence analysis.

According to an exemplary embodiment of the present invention, in the deconvolution step and in the step of measuring the concentration of antimony or cadmium in the analysis sample, the X-ray is made of molybdenum, aluminum, aluminum oxide, palladium, titanium, zirconium, and cobalt. It is irradiated to an analysis sample or a standard sample through a polarizing plate including any one or two or more selected from the group consisting of. The background value can be corrected by using the energy peak value corresponding to the material included in the polarizing plate, and when the polarizing plate contains aluminum oxide, the sensitivity of the measured X-ray spectrum is excellent.

According to an exemplary embodiment of the present invention, the quantitative analysis method of antimony or cadmium is a quantitative analysis method of antimony, and the interference element is any one or two or more selected from the group consisting of tin, tellurium, and iodine.

In the method for quantitative analysis of antimony of the present invention, tin, an interference element, has an energy level of K-alpha 25.267 keV, and tellurium has an energy level of K-alpha 27.468 keV and an energy peak of 27.468 keV. , Iodine has an energy level of K-alpha 28.607 keV.

According to an exemplary embodiment of the present invention, the quantitative analysis method of antimony or cadmium is a method of quantitative analysis of cadmium, and the interference element is any one or two or more selected from the group consisting of silver, indium, and tin.

In the method of quantitative analysis of cadmium of the present invention, the interference element silver (Silver) has an energy level of K-alpha 22.159 keV, and indium has an energy level of K-alpha 24.206 keV, and Tin has an energy level of K-alpha of 25.267 keV.

According to an exemplary embodiment of the present invention, the analysis sample is a cosmetic composition or a food composition.

The cosmetic composition may be a lotion, ointment, gel or cream formulation, and if it is in a liquid form, it is not limited thereto.

The food composition may be a beverage, and if it is in a liquid form, it is not limited thereto.

According to an exemplary embodiment of the present invention, the step of measuring the concentration of antimony or cadmium in the assay sample is performed without pretreatment of the assay sample.

According to an exemplary embodiment of the present invention, the correlation coefficient of the prepared standard calibration curve is 0.99 or more.

Hereinafter, the configuration and effects of the present invention will be described in more detail with reference to examples. However, these examples are provided for illustrative purposes only to aid understanding of the present invention, and the scope of the present invention is not limited by the following examples.

[Example 1] Selection of optimal conditions

In order to analyze antimony or cadmium contained in the sample to be analyzed with high accuracy, the following experiment was performed to determine the optimum conditions.

1-1. Selection of analysis method

As a heavy metal content analysis method, it can be measured using wet method, atomic absorption spectroscopy, and inductively coupled plasma spectroscopy.These methods are used to quantify each element by acid-treating a sample and making it a solution. However, the pretreatment time takes more than 5 hours, the safety of the tester is exposed to danger by using a highly toxic acid, and the wet method or atomic absorption spectroscopy is not suitable for quality control because simultaneous analysis is impossible and the accuracy is low.

Accordingly, the present inventors have adopted an X-ray fluorescence analysis method in which the pretreatment method is simple and the analysis time is short and accuracy is ensured without using a dangerous strong acid.

1-2. Blank sample selection

To prepare a liquid-type standard sample at an appropriate concentration, nitric acid, sulfuric acid, and phosphoric acid were tested at various concentrations as a blank solution for dilution.

The blank sample should not contain antimony or cadmium, and no other elements should be detected at positions similar to the energy level to be detected with antimony or cadmium. A blank sample for measurement of a liquid sample satisfying these conditions must be capable of dissolving a certain amount of antimony or cadmium, and a 5-10% nitric acid solution that does not dissolve the film of the sample cup was used for XRF analysis.

2-1. Eliminates the influence of peak overlap-Deconvolution

The X-ray fluorescence analyzer separates each element into its own energy value, and using the principle that the pulse height of the detector signal is proportional to the X-ray photon energy correlated with the wavelength, the energy level pulse according to the concentration of the element It has a principle that can quantify each element from

When an analysis sample containing heavy metals is exposed to X-rays, electrons at the K angle of each of these elements are released, and the electrons at the L angle move to the K angle to stabilize the orbital. Characteristic X-ray as much as the difference in level occurs, so the characteristics of each element are K, L, and M angles. .. Each element can be quantified from the energy value.

However, when the matrix of the sample is complex, the overlapping of the X-ray peaks causes a problem in the analysis accuracy.

Deconvolution is a technology that eliminates the influence of such X-ray overlap. One element has several energy values such as K _α , K _β , K _γ , L _α, L _β , L _γ, M _α , M _β , and M _γ . The ratio of their energy intensity is determined as a constant constant. In other words, if the energy intensity of K _α is 10, K _β is 6, K _γ is 2, L _α is 4, and so on.

If, as in the above illustration of the Ti K _α and K V _α overlap K _β or _α L may or may not overlap. In this case, when you remove the K _α energy value of V in the K _α of nested Ti and then calculate the energy intensity of the V with K _β or L _α energy level by the deconvolution it is able to obtain the energy values less than Ti matrix The effect can be corrected.

2-2. Selection of interference elements

In order to apply the deconvolution of 2-1, all elements contained in samples with complex matrices were scanned to select elements that may interfere.

The energy range to be analyzed for antimony and cadmium was determined and selected as elements with high possibility of interference.

2-3. Optimal conditions for analysis (antimony, cadmium)

After setting the above conditions, antimony and cadmium in the sample to be analyzed were analyzed using an X-ray fluorescence analyzer. Antimony and cadmium standard samples and analysis samples are used as aluminum oxide crystals for background correction, and interference elements are selected to eliminate matrix effects, and deconvolution is applied, and the Lucas-Tooth/Price model is used. The antimony and cadmium contained were measured with an analysis time of 1000 seconds per sample. Hereinafter, examples of the present invention were performed under the conditions of Table 1 below.

X-ray voltage 60 W Polarized crystal Aluminum oxide Detector SDD silicon drift detector
(Spectral resolution(FWHM) at Mn K-alpha ≤ 160 eV) Measurement time 1000 seconds Correction model Lucas-Tooth/Price Model

[Example 2] Analysis of antimony and cadmium in samples

Using the optimal conditions selected in Example 1, the following experiment was performed to actually analyze antimony or cadmium present in various samples.

3-1. Analyzer (XRF)

The X-ray fluorescence spectrometer used in this example was Xepos HE from Specto, and the X-Lap Pro program from Specto was used for data processing.

3-2. Standard product

Antimony (INCI name: Antimony, element name: Sb) used in the liquid standard sample was manufactured by Sigma and had a concentration of 1000 ppm, and cadmium used in the liquid standard sample (INCI name: Cadmium, element name: Cd) was manufactured by Sigma and had a concentration of 1000 ppm.

3-3. Quantitative analysis of antimony and cadmium in liquid cosmetic ingredients

A method for quantitative analysis of antimony and cadmium according to an embodiment of the present invention was performed on liquid cosmetic raw materials.

First, liquid cosmetic ingredient 1 was transferred to a sample cup in an amount of about 6 mL without air bubbles, and was used as an analysis sample. In addition, 0.1 mL, 0.5 mL, and 1 mL of the above-described antimony standard were added to a 100 mL volumetric flask, and then dispersed with 5 to 10% nitric acid solution according to the mark to have an arithmetic concentration of 1 ppm, 5 ppm, and 10 ppm. Standard samples for each concentration were prepared. The energy peak measured using an X-ray fluorescence analyzer for the analysis sample and the standard sample by concentration was calculated using the equation 1 and the least squares method under the following conditions, and the standard calibration curve using the calculated standard calibration curve According to the method, the concentration of antimony in the analyzed sample was confirmed. This procedure was carried out in the same manner for liquid cosmetic ingredients 2 to 6.

In addition, the concentration of cadmium was confirmed in the same procedure as that of antimony, except that the above procedure was performed using the above-described cadmium standard.

Spectra of liquid cosmetic ingredients 1 to 6 obtained as a result of the analysis are shown in FIG. 4, and the results of measuring the concentrations of antimony and cadmium in liquid cosmetic ingredients 1 to 6 are shown in Table 2 below.

sample Concentration (ppm) antimony cadmium Liquid Cosmetic Ingredients 1
(Product name: Solaveil CT100, manufacturer: Croda) 0 0 Liquid Cosmetic Ingredients 2
(Product name: VEGFTa Red, manufacturer: Gattefosse) 0 0.9 Liquid Cosmetic Ingredients 3
(Product name: VE2ETOL, manufacturer: Bioland) 0 0 Liquid Cosmetic Ingredients 4
(Product name: Dekanex2008FG, manufacturer: IMCD) 0 0 Liquid Cosmetic Ingredients 5
(Product name: Hydra cires, manufacturer: Gattefosse) 0 0.5

The standard calibration curve for quantifying the analyzed antimony and cadmium was prepared in the range of 1.0 to 10 ppm, and the prepared standard calibration curve showed good linearity with a correlation coefficient R of 0.999 or more, which can be confirmed through FIGS. 2 and 3 .

4-1. Comparative Example: Quantitative analysis of antimony and cadmium in liquid cosmetic ingredients using ICP-MS

① Preparation of test solution: 0.2 g of the liquid cosmetic raw material 1 was put as an analysis sample so as not to touch the wall of a container for microwave decomposition made of Teflon. In order to decompose the analysis sample, 7 mL of nitric acid and 2 mL of hydrofluoric acid were added, the lid was closed, and the container was mounted on a microwave decomposition apparatus, followed by decomposition until colorless to pale yellow in accordance with the following operating conditions 1. After cooling to room temperature, open the lid, add 20 mL of diluted boric acid (5→100), close the lid, and mount the container in a microwave decomposition device, and inactivate fluorine according to the following operating conditions 2, cool to room temperature, and carefully remove the lid. Opened and transferred the decomposition product to a 100 mL volumetric flask, washed the container and lid with an appropriate amount of distilled water, and added distilled water to make 100 mL. If there is a precipitate, it was filtered and used. This was diluted 5 times with distilled water to obtain an analysis sample solution. In addition, a blank sample solution was prepared using 7 mL of nitric acid and 2 mL of hydrofluoric acid in the same manner as the analysis sample solution.

<Operating condition 1> <Operation condition 2> Maximum power: 1000W
Maximum temperature: 200℃
Decomposition time: about 20 minutes Maximum power: 1000W
Maximum temperature: 180℃
Decomposition time: about 10 minutes

② Preparation of standard sample solution: Three or more standard sample solutions for calibration curves with different concentrations were prepared by adding diluted nitric acid (2→100) to antimony standard stock solution (1000 μg/mL). The concentration of the standard sample solution for the calibration curve was in the range of 1 to 20 ng of antimony per 1 mL of the solution.

③ Test operation: The amount of antimony in the sample solution was measured using the calibration curve of antimony obtained by injecting each standard solution into an inductively coupled plasma mass spectrometry (ICP-MS) according to the following operating condition 3 .

<Operation condition 3>

Atomic weight: 206, 207, 208 (select and detect in the range without interference)

Plasma gas: Argon (more than 99.99 v/v%)

④ In steps ① to ③ above, the amount of antimony in the sample solution was measured by performing the same procedure except that the liquid cosmetic raw material 1 was replaced with the liquid cosmetic raw material 2 to 5, respectively.

⑤ Measure the amount of cadmium in the sample solution by performing the same procedure as in steps ① to ④ above, except that all antimony used as cadmium and that operation condition 3 in step ③ was replaced with operation condition 4 below. I did.

<Operation condition 4>

Atomic weight: 206, 207, 208 (select and detect in the range without interference)

Plasma gas: Argon (more than 99.99 v/v%)

4-2. Quantitative analysis according to an embodiment of the present invention and comparison of quantitative analysis results according to an embodiment of the present invention

In Table 4 below, XRF analysis results of antimony and cadmium in an analysis sample according to an embodiment of the present invention and analysis results of antimony and cadmium using ICP-MS according to a comparative example with respect to liquid cosmetic ingredients 1 to 5 are compared and shown. Done.

sample Content (ppm) antimony cadmium XRF ICP-MS XRF ICP-MS Liquid Cosmetic Ingredients 1 0 0 0 0 Liquid Cosmetic Ingredients 2 0 0 0.9 0.5 Liquid Cosmetic Ingredients 3 0 0 0 0 Liquid Cosmetic Ingredients 4 0 0 0 0 Liquid Cosmetic Ingredients 5 0 0 0.5 0

From the results of Table 4, the analysis method of antimony or cadmium according to the embodiment of the present invention is simple without pretreatment of the sample to be analyzed, and the analysis time is short, compared to the method of analyzing antimony or cadmium using ICP-MS. It has been confirmed that it is possible to deduce and is suitable for sample analysis of various matrices, including the step of correcting the matrix effect, and the Relative Standard Deviation between the ICP-MS and the analysis result is all within 1%. It was confirmed that this is possible.

Claims (10)

Preparing a blank liquid standard sample with nitric acid solution;
Adding antimony or cadmium to the nitric acid solution to prepare a liquid standard sample of two or more concentrations having different concentrations;
Selecting an interference element whose energy value is within the range of the detected energy value of antimony or cadmium from among the detected winsos by irradiating X-rays on the analysis sample;
Preparing a standard calibration curve by performing a deconvolution step to remove the overlapping effect of the detected energy peak after irradiating each of the prepared liquid standard samples by X-ray; And
After detecting the energy peak by irradiating X-rays on the analysis sample, measuring the concentration of antimony or cadmium in the analysis sample according to a standard calibration method using a standard calibration curve prepared with the detected energy peak value; includes,
The deconvolution step includes correcting the detection energy peak of antimony or cadmium from the detected energy peaks of overlapping interference elements among energy peaks detected by irradiating X-rays to a liquid standard sample for each concentration. Method for quantitative analysis of cadmium. The method of claim 1,
The deconvolution step includes a step of correcting an interference element absorption effect in which an energy intensity value corresponding to an energy level range in which the detected energy peak of the detected antimony or cadmium and the energy peak of the selected interference element overlap. Antimony or cadmium quantitative analysis method, characterized in that it further comprises. The method of claim 2,
The step of correcting the absorption effect of the interference element further comprises correcting the detection energy peak of antimony or cadmium using a Lucas-Tooth/Price algorithm. Method of quantitative analysis. The method of claim 3,
The step of correcting the detection energy peak of antimony or cadmium by the Lucas-Tooth/Price algorithm further comprises correcting the detection energy peak of antimony or cadmium according to Equation 1 below. Way:
[Equation 1]

In Equation 1, i is antimony or cadmium, j is an element other than antimony or cadmium, W _i is the mass-based concentration of antimony or cadmium in the sample, I _i is the intensity of the energy peak of antimony or cadmium, and I _j is antimony or Intensity of the energy peak of an element other than cadmium, k _i is the proportionality constant of the mass-based concentration value to the detection energy intensity of antimony or cadmium, and a _ij is the detection energy peak of the interfering element with respect to the detection energy peak of antimony or cadmium. The absorption effect (absorption effect) means a correction constant, and B _i means a background constant when the concentration of antimony or cadmium is 0. The method of claim 1,
In the step of preparing the liquid standard sample and preparing the liquid standard sample for each concentration, the concentration of the nitric acid solution is 5 to 10%. The quantitative analysis method of antimony or cadmium. The method of claim 1,
In the deconvolution step and measuring the concentration of antimony or cadmium in the analysis sample,
The detection of the energy peak is a quantitative analysis method of antimony or cadmium, characterized in that the detection by X-ray fluorescence analysis. The method of claim 6,
The X-ray of the X-ray fluorescence analysis is irradiated to an analysis sample or a standard sample through a polarizing plate containing any one or two or more selected from the group consisting of molybdenum, aluminum, aluminum oxide, palladium, titanium, zirconium, and cobalt. Antimony or cadmium quantitative analysis method, characterized in that. The method of claim 1,
The quantitative analysis method of antimony or cadmium is a quantitative analysis method of antimony,
The interference element is a method for quantitative analysis of antimony or cadmium, characterized in that any one or two or more selected from the group consisting of tin, tellurium and iodine. The method of claim 1,
The quantitative analysis method of antimony or cadmium is a quantitative analysis method of cadmium,
The interference element is a method for quantitative analysis of antimony or cadmium, characterized in that any one or two or more selected from the group consisting of silver, indium and tin. The method of claim 1,
The analysis sample is a method for quantitative analysis of antimony or cadmium, characterized in that the cosmetic composition or food composition.

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