KR102078334B1 - Sheetless hydrogel film and Preparing method ofthere - Google Patents

Abstract

The present invention relates to a sheetless hydrogel film and a method for manufacturing the same. More specifically, the present invention provides a mechanical property and adhesion properties such as tensile strength and tensile stress without a base layer such as a nonwoven fabric, a mesh, and a net. The excellent sheetless hydrogel film and its manufacturing method are related.

Description

Sheetless hydrogel film and preparation method thereof {Sheetless hydrogel film and Preparing method of there}

The present invention relates to a sheetless hydrogel film having excellent mechanical properties and adhesion without a base layer such as a nonwoven fabric, a mesh, and a net, and a method of manufacturing the same.

Hydrogel refers to a film having a three-dimensional hydrophilic polymer network structure, a film having a capacity to absorb water, in which a large amount of water is filled in a lattice of a polymer material and swelled. The hydrogel film has the flexibility to absorb moisture by forming a structurally stable three-dimensional network structure with little fluidity due to external hysteresis, and thus has the same flexibility as a natural tissue.

Research and development of hydrogel patches or cosmetic packs have been actively made by using the elasticity, adhesion, and soft touch of such hydrogels or films made from hydrogels. However, when the film is manufactured using only the hydrogel itself, it is often difficult to maintain the shape due to weak mechanical strength or torn, and thus it is generally used in addition to the nonwoven fabric, mesh, and net. However, in this case, a process of applying or transferring a base layer such as a nonwoven fabric, a mesh, or a net to a pack layer is complicated, and the process is complicated. When a lotion or a functional extract is added, the process becomes stiff and the adhesion is not good. There have been many problems, such as when it comes off.

Accordingly, the present invention is to provide a hydrogel film made of only the hydrogel itself without using a substrate layer (or a substrate film, or a substrate sheet) such as nonwoven fabric to solve the problems of the existing hydrogel film.

The present invention for solving the above problems is a hydrogel comprising a polymer resin, sodium alginate, plasticizer and humectant containing at least one selected from a sheetless hydrogel film water-soluble polymer and natural polymer; And a crosslinking swelling agent.

In a preferred embodiment of the present invention, in the present invention, the cross-linking swelling agent containing at least one selected from Ca ²⁺ , Mg ^{2 +} , Cu ^{2 +} , Fe ^{2 +} , Al ^{3 +} and Fe ^{3 +} It may be characterized by including a compound.

As another preferred embodiment of the present invention, the crosslinking swelling agent may be characterized in that it comprises 0.01 to 10% by weight of the compound and 90 to 99.99% by weight of distilled water in the total weight of the crosslinking swelling agent.

As another preferred embodiment of the present invention, the sheetless hydrogel film of the present invention may be characterized in that it comprises 10 to 40 parts by weight of the crosslinking swelling agent with respect to 100 parts by weight of the hydrogel.

In another preferred embodiment of the present invention, in the present invention, the water-soluble polymer is a water-soluble polymer and a natural polymer as polylysine, carboxymethyl chitin, fibrin, dextran, polyvinyl alcohol, polyvinylacetate / polyvinyl alcohol At least one selected from poly (N-vinyl pyrrolidone), alginate-g- (polyethylene oxide-polypropylene oxide-polyethylene oxide), alginate-acrylate, polyethylene oxide and polyethylene oxide-polypropylene oxide copolymer It can be characterized by.

In another preferred embodiment of the present invention, in the present invention, the natural polymer is pectin, xanthan gum, gelatin, locust bean gum, agar, glucomannan, carrageenan, gelatin, gellan gum, chitosan, collagen, hyaluronic acid, acacia It may be characterized by including one or more selected from gum, gum arabic and cellulose.

As another preferred embodiment of the present invention, in the present invention, as the plasticizer, hexyldecylbenzoate, fiji-3 benzyl ether myristate, polyethylene glycol, PJ-8 / SM diaicopolymer, tricaprylyl / Capryl trimellitate, trioleyl phosphate, trioctylimellitate, triethylhexyl trimellitate, triethylhexate, triacetin, tricetyl phosphate, tributyl citrate, trimethylhydroxypentyl isobutyrate, Trimethylpentanediyldibenzoate, camphor, acetyltriethyl citrate, acetyltributyl citrate, sucrose acetate isobutyrate, butyloctylbenzoate, dipentaerythryl hexa C5-9 acid ester, dicapryl adipate, di Isopropyl adipate, diisopropyl sebacate, diisostearyl adipate, diisobutyl adiate Fate, diisodecyl adipate, diethylhexyl adipate, diethylhexyl sebacate, diethylhexyl succinate, diethyl phthalate, diethyl oxalate, diethyl sebacate, diethylene glycol diisononano It may be characterized in that it comprises one or more selected from ate, dibutyl adipate, dimethicone page 8 polyacrylate, and decyl oxazolidinone.

As another preferred embodiment of the present invention, in the present invention, the moisturizing agent may be characterized in that it comprises one or more selected from glycerin, sorbitol and 1,3-butylene glycol.

As another preferred embodiment of the present invention, in the present invention, the hydrogel is 20 to 80% by weight polymer resin, 5 to 20% by weight sodium alginate, 2 to 35% by weight plasticizer, 5 to 40% by weight moisturizer It can be included.

In addition, as a preferred embodiment of the present invention, the hydrogel may be characterized in that the average thickness of 20㎛ ~ 100㎛.

In addition, as a preferred embodiment of the present invention, the sheetless hydrogel film of the present invention is formed in the groove portion and the projection of the intaglio on the surface in contact with the skin so that the reservoir of the active material and water is formed, the boundary of the groove portion It may be characterized in that the protruding boundary line protruding from the surface of the dry film is formed. In addition, the sheetless hydrogel film of the present invention may be characterized in that the groove portion and the projection portion is formed on both sides of the film.

In addition, as a preferred embodiment of the present invention, the sheetless hydrogel film of the present invention may be characterized in that the average thickness of 25 ㎛ ~ 250 ㎛.

Another aspect of the invention relates to a method for producing a sheetless hydrogel film described above, comprising the steps of preparing a resin for a hydrogel; Coating the hydrogel resin on a release film surface and then drying to form a hydrogel; And penetrating a crosslinking swelling agent to the hydrogel formed on the surface of the release film to crosslink and swell the hydrogel.

As a preferred embodiment of the present invention, the hydrogel resin may include a polymer resin containing at least one selected from a water-soluble polymer and a natural polymer, sodium alginate, a plasticizer, a humectant, and distilled water. And, the content is 1 to 40% by weight of the polymer resin, 0.05 to 20% by weight of the sodium alginate, 0.1 to 20% by weight of the plasticizer, 0.1 to 20% by weight of the moisturizer and 20 to 98% by weight of the distilled water It can be characterized.

As a preferred embodiment of the present invention, the drying of the step of forming the hydrogel may be characterized in that performed for 2 minutes to 20 minutes under 50 ℃ ~ 90 ℃.

In another preferred embodiment of the present invention, the step of crosslinking and swelling may be characterized by impregnating a hydrogel formed on the surface of the release film in a crosslinking swelling agent.

As another preferred embodiment of the present invention, the step of crosslinking and swelling may be characterized by spraying a crosslinking swelling agent on the surface of the hydrogel formed on the surface of the release film.

Another aspect of the present invention can be applied to the various forms of the sheetless hydrogel film described above in a variety of products, the product may include a cosmetic mask pack, medical patch and the like.

Since the sheetless hydrogel film of the present invention has excellent mechanical strength such as tensile strength and tensile stress, it is not necessary to have a base layer such as a nonwoven fabric, a mesh, and a net for maintaining the shape of the film and maintaining the mechanical strength. Because there is no base layer, flexibility is good, adhesion to skin, adhesion and usability are excellent, and there is no manufacturing process to form base layer, so the process is simplified compared to the process of manufacturing a hydrogel film. Excellent economy

1 is a front view of a sheetless hydrogel mask pack as an embodiment of the present invention.
2 is a cross-sectional view taken along the line II-II shown in FIG. 1.
3 to 7 are schematic views of a hydrogel film having grooves formed in different shapes from those shown in FIGS. 1 and 2.
Figure 8 shows an example of applying the sheetless hydrogel film of the present invention in the form of a cosmetic mask pack.

The term "distilled water" used in the present invention is meant to include pure water, such as deionized water, purified water.

The terms "active substance" and / or "active ingredient" used in the present invention are meant to include cosmetic ingredients, cosmetic ingredients, pharmaceutical ingredients and the like used according to the use of the sheetless hydrogel film of the present invention.

Hereinafter, the present invention will be described in more detail.

Since the hydrogel film of the present invention has excellent mechanical properties in itself, a base layer (or a base sheet, a base film) is unnecessary, and the hydrogel film of the present invention is a hydrogel; And a crosslinking swelling agent.

In the present invention, the cross-swelling agent to the role of cross-linking and expanding the hydrogel, approaching as such cross-linking the swelling agent may be used a compound containing a cation, preferably Ca ^{2 +,} Mg ^{2 +,} Cu ^{2 +,} Fe ^{2 +,} Al ^{3 +} and Fe ^{3 +} to these, and more preferably comprises a compound containing a selected one or more can be used a compound containing at least one member selected from the group consisting of Ca ^{2 +} and Mg ^{2 +} have. In more detail, compounds such as Ca (OH) ₂ , CaCl ₂ , C ₆ H ₁₀ CaO ₆ , Mg (OH) ₂ , MgCl ₂ , Mg (NO ₃ ) ₂ , MgS, MgSO ₄ and MgCO ₃ Can be used.

In the present invention, the crosslinking swelling agent 0.01% to 10% by weight of the compound in the total weight of the crosslinking swelling agent, preferably 0.1% to 8% by weight, more preferably 1% to 5% by weight It may include, and the other remaining composition of the crosslinking swelling agent may include distilled water in addition to the compound. In the crosslinking swelling agent, when the content of the compound is less than 0.01% by weight, sufficient crosslinking and swelling effects with the hydrogel are not observed, and when the amount of the compound exceeds 10% by weight, the hydrogel is swelled so that the thickness of the film becomes thick. It is preferable to include the compound within the above range since there may be a problem that it is hard and there is no flexibility.

In addition, in the sheetless hydrogel film of the present invention, the amount of the crosslinked swelling agent is preferably used in an amount of 10 parts by weight to 40 parts by weight based on 100 parts by weight of the hydrogel. Here, when the amount of the crosslinking swelling agent is less than 10 parts by weight, the amount of the crosslinking swelling agent is too small, so that sufficient crosslinking and swelling effects are not observed.

In the present invention, the hydrogel may include a polymer resin, sodium alginate, a plasticizer and a humectant containing at least one selected from a water-soluble polymer and a natural polymer, wherein the hydrogel is 20% by weight to 80% by weight of the polymer resin. 5 wt% to 20 wt% of sodium alginate, 2 wt% to 35 wt% of a plasticizer, and 5 wt% to 40 wt% of a humectant.

The water-soluble polymer is polylysine, carboxymethyl chitin, fibrin, dextran, polyvinyl alcohol (PVA) polyvinylacetate / polyvinyl alcohol (PVAc / PVA), poly (N-vinylpi Ralidone) (PVP), alginate-g- (polyethylene oxide-polypropylene oxide-polyethylene oxide) (alginate-g- (PEO-PPO-PEO)), alginate-acrylate, polyethylene oxide (PEO ) And polyethylene oxide-polypropylene oxide copolymers (PEO-PPO, Pluronic series), at least one selected from PVA, PVAc / PVA, PVP, PEO and PEO-PPO can do.

The natural polymer is pectin, xanthan gum, gelatin, locust bean gum (LBG), agar (Agar), glucomannan, carrageenan, gellanum (gellangum). ), Chitosan, collagen, hyaluronic acid, acacia gum, gum arabic and cellulose, at least one selected from gelatin, plastic, xanthan gum, glucomannan, guar gum, chitosan, collagen and cellulose. It can be characterized by.

The polymer resin may include 20 wt% to 80 wt% of the total weight of the hydrogel, preferably 20 wt% to 75 wt%, and if less than 20 wt%, the mechanical properties of the prepared hydrogel film may be deteriorated. And, if it exceeds 80% by weight, the viscosity is too high, there may be a difficulty in the coating operation is good to use within the above range.

In the present invention, the sodium alginate, which is one of the hydrogel components, is a hydrophilic natural polymer, which serves to form a crosslinking role by a polyvalent cation, that is, a matrix, and 5 wt% to 20 wt% of the total weight of the hydrogel. To include, preferably 6 to 18% by weight, if less than 5% by weight may cause a problem of difficult cross-linkability of the matrix formation, if the content exceeds 20% by weight is too high viscosity is not easy to use It may be a problem to use within the above range.

As the plasticizer, which is one of the hydrogel components, in the present invention, serves to add flexibility to the dried film, 2% to 35% by weight of the total weight of the hydrogel, preferably 5% to 35% by weight If less than 2% by weight, the dried film may have a problem of cracking or cracking due to its inflexibility, and when it exceeds 35% by weight, the drying may not be performed well, or the dried film may be sticky even if dried. Since there may be, it is good to use within the above range.

The plasticizer is hexyldecyl benzoate, Fiji-3 benzyl ether myristate, PPG-3 Benzyl Ether Myristate, polyethylene glycol (PEG), Fiji-8 / SMDIicopolymer (PEG-8 / SMDI Copolymer), Tricaprylyl / Capryl Trimellitate, Trioleyl Phosphate, Trioctyl Trimellitate, Triethylhexyl Trimellitate , Triethylhexyl Citrate, Triacetin, Tricetyl Phosphate, Tributyl Citrate, Trimethyl Hydroxypentyl Isobutyrate, Trimethylpentanedi Trimethylpentanediyl Dibenzoate, Camphor, Acetyl Triethyl Citrate, Acetyl Tributyl Citrate ibutyl Citrate, Sucrose Acetate Isobutyrate, Butyloctyl Benzoate, Dipentaerythrityl Hexa C5-9 Acid Esters, Dicapryl Adipate (Dicapryl Adipate), Diisopropyl Adipate, Diisopropyl Sebacate, Diisostearyl Adipate, Diisobutyl Adipate, Diisobutyl Adipate Diisodecyl Adipate, Diethylhexyl Adipate, Diethylhexyl Sebacate, Diethylhexyl Succinate, Diethyl Phthalate, Diethyl Oxalate (Diethyl Oxalate), Diethyl Sebacate, Diethylene Glycol Diisononanoate, Dibutyl Adipate It may be characterized in that it comprises at least one selected from, dimethicone PEG-8 Polyacrylate (Dimethicone PEG-8 Polyacrylate), and decyloxazolidinone (Decyloxazolidinone).

In addition, the moisturizing agent which is one of the hydrogel components serves to maintain the active ingredient, such as water, active substances of the hydrogel film of the present invention, preferably 5 to 40% by weight of the total weight of the hydrogel, preferably 5 wt% to 35 wt% may be included. If less than 5 wt%, the effect may be inferior due to insignificant effects, and if it exceeds 40 wt%, it may be too sticky. It is good. In addition, the moisturizing agent is one or more selected from glycerin, sorbitol, propylene glycol, polypropylene glycol, and 1,3-butylene glycol, preferably one selected from glycerin, sorbitol, and 1,3-butylene glycol. The above can be used.

Hydrogel prepared through the composition is preferably an average thickness of 20㎛ ~ 100㎛, preferably 25㎛ ~ 80㎛, if the average thickness of the hydrogel is less than 20㎛ the thickness of the hydrogel film is too thin mechanical strength There may be a problem of weakening, and if it exceeds 100 ㎛ there may be a problem that the thickness of the swollen hydrogel film becomes too thick.

The hydrogel is crosslinked and swollen by a crosslinking swelling agent to prepare a sheetless hydrogel film of the present invention, and the average thickness of the swollen sheetless hydrogel film is 25 μm to 250 μm, preferably 30 μm to 200. It is preferable that they are 50 micrometers-150 micrometers more preferably.

The sheetless hydrogel film of the present invention may be manufactured in an intangible form without grooves and protrusions, or may be manufactured in an intaglio and / or embossed form in which grooves and protrusions are formed. As an example, as shown in the front view of Figure 1 and the cross-sectional view of Figure 2 between the grooves (10a, 10b) and the groove portion of the intaglio on the surface in contact with the skin to form a reservoir of active ingredients and moisture, such as the active material Protrusions are formed in, but the boundary of the groove portion may be characterized in that the protruding boundary line 10c protruding from the surface of the film is formed. In addition, the sheetless hydrogel film of the present invention may be characterized in that the groove portion and the projection portion is formed on only one side or both sides of the film.

 2, both sides of the mask pack 10 according to the present invention can be seen. It can be seen that the grooves 10a and 10b are formed in both the upper and lower portions. Therefore, the active ingredient and the active material, such as the upper and lower sides are supplied to either side, the user can use any side. And, the reference numeral 20 is drawn assuming that the active ingredient, such as the active material. As the grooves 10a and 10b are formed as compared with the general surface, the surface tension is increased due to the large surface area in contact with the active ingredient and moisture such as the active material, so that the amount of the surface tension is increased so that not only a large amount can be stored but also not flowed down. In addition, protruding boundary line 10c protruding from the surface of the hydrogel film 10 is formed at the boundary between the groove portions 10a and 10b of the hydrogel film of the present invention, whereby the surface tension increases and flows down. The prevention effect can be improved.

3 to 7 each show a hydrogel film in which grooves are formed in a different form from the embodiment shown in FIGS. 1 and 2, and FIGS. 3 and 4 each have a groove formed in a square and a hexagon. 5 to 7 are each formed by protrusions in a circle, a square, and a hexagon instead of a groove, and may form a groove and a protrusion in an effective form according to a situation to manufacture the hydrogel film of the present invention. And, Figure 8 shows an example of applying the sheetless hydrogel film of the present invention in the form of a cosmetic mask pack, it is divided into an upper mask pack 100 and a lower mask pack 200. By having such a configuration, it is possible to apply more to the curvature of the face than when the sheetless hydrogel film is composed of one sheet. Since the face is not a plane but a three-dimensional structure having three-dimensional curvatures, the face may be more corresponded to the curvature of the face. Of course, all these aspects can be applied in the form of the above-described intaglio and / or embossed.

Hereinafter, a method of manufacturing the sheetless hydrogel film described above will be described.

Hydrogel film of the present invention can be prepared by infiltrating the cross-linking swelling agent to the hydrogel, if specifically described, preparing a resin for a hydrogel; Coating the hydrogel resin on a release film surface and then drying to form a hydrogel; And infiltrating a hydrogel formed on the surface of the release film to crosslink and swell the hydrogel.

The hydrogel resin may include a polymer resin containing at least one selected from a water-soluble polymer and a natural polymer, sodium alginate, a plasticizer, a humectant, and distilled water. And, the content is 1% to 40% by weight of the polymer resin, 0.05% to 20% by weight of the sodium alginate, 0.1% to 20% by weight of the plasticizer, 0.1% to 20% by weight of the moisturizer and the distilled water 20 It may be characterized by including a weight% to 98% by weight.

And, the drying of the step of forming the hydrogel may be carried out under 50 ℃ ~ 90 ℃, 2 minutes to 20 minutes, preferably 50 ℃ to 80 ℃, 5 minutes to 10 minutes, if the drying is performed As the distilled water contained in the hydrogel resin applied to the film surface is evaporated, the hydrogel resin is gelated to form a hydrogel.

In addition, the step of crosslinking and swelling may include crosslinking and swelling the hydrogel by impregnating a hydrogel formed on the surface of the release film or spraying (or applying) a crosslinking swelling agent on the surface of the hydrogel formed on the surface of the release film. The agent can be penetrated to effect crosslinking and swelling.

When the hydrogel is swollen by the crosslinking swelling agent, the hydrogel is separated from the release film by swelling. Therefore, there is no need for a separate process of separating the sheetless hydrogel film produced from the release film.

The various forms of the sheetless hydrogel film described above have excellent mechanical strengths in themselves, and thus do not necessarily require a base film (or a base layer), and thus have excellent peelability, adhesion to skin, and adhesion. The sheetless hydrogel film of the present invention can be widely applied to various products, such as a cosmetic mask pack, a medical patch.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to the following Examples.

[ Example ]

Preparation  : Of crosslinking swelling agent  Produce

30 g of 2-hydroxypropanoic acid calcium salt (C ₆ H ₁₀ CaO ₆ ) was added to 1 L of distilled water, followed by stirring to obtain a crosslinking swelling agent containing 3% by weight of C ₆ H ₁₀ CaO ₆ . Prepared.

Example  One

At 25 ° C., polyvinyl alcohol (PVA) resin (PVA product of O company, weight average molecular weight = 85,000), sodium alginate, xanthan gum (JMU of J), pectin, glycerin (glycerine of M), polyethylene glycol (PEG, G) PEG1500) and distilled water were stirred and mixed at a weight% as shown in Table 1 to prepare a resin for a hydrogel.

Next, the hydrogel resin was applied to the surface of the polyethylene terephthalate film (PET film, release film) in which a circular relief was formed on the surface as opposed to the form as shown in FIG. 1 using an automatic applicator.

Next, the PET film coated with the resin for hydrogel was added to a dryer, followed by drying at 70 ° C. for 10 minutes to gel the hydrogel resin to form a hydrogel (PET film-hydrogel) on the top surface of the PET film. The thickness of the gelled or dried hydrogel was 62 μm.

Next, after the PET film-hydrogel was put into the pouch, the crosslinked swelling agent prepared in Preparation Example was filled into the pouch, and the crosslinked swelling agent was left for 8 minutes to allow the PET film-hydrogel to be permeable, and a sheet having a thickness of 105 μm. A lith hydrogel film was prepared, and the crosslinking swelling agent was included in an amount of 33 parts by weight based on 100 parts by weight of the hydrogel of the prepared film, which was confirmed through weight change before and after the permeation.

Example  2 to Example  12 and Comparative example  1 to 6

A sheetless hydrogel film was prepared in the same manner as in the above example, but the composition and composition ratio of the hydrogel resin were changed as shown in Table 1 and Table 2 to prepare a sheetless hydrogel film, and the examples and the comparative examples were performed. The composition of the hydrogel after drying is shown in Table 3 below.

Example Polymer resin Alginic acid
salt Moisturizer
(glycerin) Plasticizer
(PEG) Distilled water Water soluble polymer Natural Polymer One (1) -1 weight% ①-1.4 wt%
②-2 weight% 2.1 wt% 5 wt% 5 wt% 83.5 wt% 2 (1) -3 weight% ①-3 weight%
②-6% by weight 2.1 wt% 5 wt% 5 wt% 75.9 wt% 3 (1) -5% by weight ①-1.4 wt%
②-2 weight% 2.4 wt% 5 wt% 5 wt% 79.2% by weight 4 (1) -10 weight% ①-2.5% by weight
②-5% by weight 2.1 wt% 5 wt% 10% by weight 65.4 wt% 5 (2) -1 weight% ①-1 weight%
②-2 weight% 2% by weight 5 wt% 5 wt% 84% by weight 6 (2) -1 weight% ①-1.3% by weight
②-4 weight% 1.7 wt% 1.3 wt% 3.3 wt% 87.4% by weight 7 (2) -5% by weight ①-0.5% by weight
③-3 weight% 2% by weight 1 wt% 4 wt% 84.5 wt% 8 (2) -2.4% by weight ①-1.4 wt%
②-2.7% by weight 2.1 wt% 3 wt% 2% by weight 86.4% by weight 9 (2) -2 weight%
(3) -5% by weight ②-6% by weight
④-10% by weight 2% by weight 5 wt% 5 wt% 65 wt% 10 (3) -3 weight% ②-2 weight%
④-15% by weight 2.7 wt% 2.5 wt% 2.5 wt% 72.3 wt% 11 (1) -2 weight%
(3) -5% by weight ②-6% by weight
⑤-2 weight% 2% by weight 5 wt% 5 wt% 73% by weight 12 (1) -5% by weight ②-2.1 wt%
⑤-3% by weight 2.7 wt% 2% by weight 1 wt% 84.2% by weight (1): PVA (polyvinyl alcohol), (2): PVP (poly (N-vinylpyrrolidone), (3): PEO (polyethylene oxide)
①: xanthan gum, ②: pectin, ③: glocomannan, ④: guar gum, ⑤: chitosan

Comparative example Polymer resin Alginic acid
salt Moisturizer
(glycerin) Plasticizer
(PEG) Distilled water Water soluble polymer Natural Polymer One (2) -1 weight% ①-7% by weight 2% by weight 10% by weight - 80 wt% 2 (2) -3.1 weight% - 3.6% by weight 15 wt% - 78.3% by weight 3 (2) -1 weight%
(3) -3 weight% ②-1 weight%
④-10% by weight 1.6 wt% - 3 wt% 80.4% by weight 4 (2) -1 weight%
(3) -3 weight% ②-1 weight%
④-10% by weight 1.6 wt% 3 wt% - 80.4% by weight 5 (1) -3 weight%
(3) -1 weight% ①-1 weight%
⑤-2 weight% 2% by weight - 3 wt% 88 wt% 6 (1) -3 weight%
(3) -1 weight% ①-1 weight%
⑤-2 weight% 2% by weight 3 wt% - 88 wt% (1): PVA (polyvinyl alcohol), (2): PVP (poly (N-vinylpyrrolidone), (3): PEO (polyethylene oxide)
①: xanthan gum, ②: pectin, ③: glocomannan, ④: guar gum, ⑤: chitosan

division Polymer resin Alginic acid
salt Moisturizer
(glycerin) Plasticizer
(PEG) Water soluble polymer Natural Polymer Example 1 6.1 wt% 20.6 12.7 wt% 30.3 wt% 30.3 wt% Example 2 12.5 wt% 37.3 wt% 8.8% by weight 20.7 wt% 20.7 wt% Example 3 24% by weight 16.4 wt% 11.6 wt% 24% by weight 24% by weight Example 4 28.9 wt% 21.7 wt% 6.1 wt% 14.4 wt% 28.9 wt% Example 5 6.2% by weight 18.7% by weight 12.5 wt% 31.3 wt% 31.3 wt% Example 6 7.9% by weight 42.1 wt% 13.5 wt% 10.3 wt% 26.2 wt% Example 7 32.3 wt% 22.6 wt% 12.8 wt% 6.5 wt% 25.8% by weight Example 8 17.7 wt% 30.2 wt% 15.4 wt% 22% by weight 14.7 wt% Example 9 20 wt% 45.7 wt% 5.7 wt% 14.3% by weight 14.3% by weight Example 10 10.8 wt% 61.5 wt% 9.7 wt% 9% by weight 9% by weight Example 11 25.9 wt% 29.6 wt% 7.5 wt% 18.5 wt% 18.5 wt% Example 12 31.6 wt% 32.3 wt% 17.1 wt% 12.7 wt% 6.3 wt% Comparative Example 1 5 wt% 35 wt% 10% by weight 50 wt% - Comparative Example 2 14.3% by weight - 16.7 wt% 69% by weight - Comparative Example 3 20.4% by weight 56.1 wt% 8.2% by weight - 15.3% by weight Comparative Example 4 20.4% by weight 56.1 wt% 8.2% by weight 15.3% by weight - Comparative Example 5 33.3 wt% 25% by weight 16.7 wt% 25% by weight - Comparative Example 6 33.3 wt% 25% by weight 16.7 wt% - 25% by weight (1): PVA (polyvinyl alcohol), (2): PVP (poly (N-vinylpyrrolidone), (3): PEO (polyethylene oxide)
①: xanthan gum, ②: pectin, ③: glocomannan, ④: guar gum, ⑤: chitosan

Experimental Example  : Seatless Hydrogel  Film The tensile strength  Measurement experiment

Tensile strength measurement was made of the sheetless hydrogel film prepared in the above Examples and Comparative Examples 30mm × 12mm in width, and then the tensile strength was tested by pulling out each of these films to measure the breaking point, The results are shown in Table 4 below.

And the average thickness of the produced film is shown in Table 4 together.

division Tensile strength at maximum load
(Tensile strain at Maxium Load,%) Tensile Stress at Maximum Load
(Tensile stress at Maximum Load, kgf / cm ² ) Example 1 158.85 28.69 Example 2 162.36 29.85 Example 3 168.22 30.54 Example 4 183.03 32.98 Example 5 159.36 28.92 Example 6 157.98 27.88 Example 7 160.37 29.41 Example 8 160.05 30.01 Example 9 170.21 31.23 Example 10 168.72 30.08 Example 11 175.36 32.03 Example 12 181.54 33.57 Comparative Example 1 133.52 21.50 Comparative Example 2 138.64 22.82 Comparative Example 3 140.28 23.55 Comparative Example 4 142.39 23.83 Comparative Example 5 141.25 24.20 Comparative Example 6 139.41 24.05

Looking at the experimental results of Table 4, the sheetless hydrogel film of the present invention of Examples 1 to 12 is 150% ~ the appropriate tensile strength and tensile stress range at the maximum load required to use the hydrogel film as a product 190% and 25 kgf / cm ² To 35 kgf / cm ² However, in Comparative Example 1, Comparative Example 2, Comparative Example 4 and Comparative Example 5, it was confirmed that the proper tensile strength and / or tensile stress is not satisfied. In Comparative Examples 3 and 5, the tensile strength and the tensile stress were better than those of the other comparative examples, but the productability was very poor due to the inability to maintain the moisturizing force.

Through the above examples and experimental examples, the hydrogel film of the present invention has excellent physical properties such as excellent tensile strength, moisturizing force, and adhesive force, and it can be confirmed that its shape can be maintained even without a base film (or base layer, base sheet). there was. In addition, since there is no base film, the flexibility of the film itself is secured, and since peeling is possible, it can be seen that the adhesion to the skin is excellent. In addition, since there is no manufacturing process for forming the base film, the process is simplified compared to the process of manufacturing the existing hydrogel film, and it was confirmed that the production of a hydrogel film having excellent economical efficiency is possible.

10: hydrogel film 10a, 10b: groove portion
10c: protrusion boundary line 100: upper mask pack
200: lower mask pack

Claims (19)

delete delete delete delete Hydrogel comprising 5% to 20% by weight of sodium alginate, 2% to 35% by weight of a plasticizer and 5% to 40% by weight of a moisturizer, and a balance of a polymer resin; And
And a crosslinking swelling agent comprising 0.1 to 10% by weight of a compound containing at least one selected from Ca ²⁺ , Mg ²⁺ , Cu ²⁺ , Fe ²⁺ , Al ³⁺ and Fe ³⁺ .
The polymer resin includes a water-soluble polymer and a natural polymer,
The water-soluble polymer is polyvinyl alcohol (PVA) polyvinyl acetate / polyvinyl alcohol (PVAc / PVA), poly (N-vinyl pyrrolidone) (PVP), polyethylene oxide (PEO) and polyethylene oxide-polypropylene oxide copolymer (PEO-PPO, Pluronic series), one or more selected from
The natural polymer includes two or more selected from gelatin, facsimile, xanthan gum, glucomannan, guar gum and chitosan,
The crosslinking swelling agent
10 to 40 parts by weight of the crosslinking swelling agent based on 100 parts by weight of the hydrogel,
The hydrogel has a mean thickness of 20㎛ ~ 100㎛, the sheetless hydrogel film, characterized in that the average thickness of the sheetless hydrogel film swelled by the cross-linking swelling agent is 30㎛ ~ 250㎛.
The method of claim 5, wherein the plasticizer
Hexyldecyl Benzoate, Fiji-3 Benzyl Ether Myristate, Polyethyleneglycol, PG-8 / SMDI Copolymer, TREE Caprylyl / Capryl Trimellitate, Trioleyl Phosphate, Trioctyl Trimellitate, Triethylhexyl Trimellitate, Triethylhexyl Trithylhexyl Citrate, Triacetin, Tricetyl Phosphate, Tributyl Citrate, Trimethyl Hydroxypentyl Isobutyrate, Trimethylpentyldiyldibenzoate Dibenzoate, Camphor, Acetyl Triethyl Citrate, Acetyl Tributyl Citrate, Suke Sucrose Acetate Isobutyrate, Butyloctyl Benzoate, Dipentaerythrityl Hexa C5-9 Acid Esters, Dicapryl Adipate, Dicapryl Adipate, Dicapryl Adipate, Dicapryl Adipate, Dicapryl Adipate Diisopropyl Adipate, Diisopropyl Sebacate, Diisostearyl Adipate, Diisobutyl Adipate, Diisodecyl Adipate, Diethylhexyl Adipate, Diethylhexyl Sebacate, Diethylhexyl Succinate, Diethyl Phthalate, Diethyl Oxalate, Diethyl Oxalate Diethyl Sebacate, Diethylene Glycol Diisononanoate, Dibutyl Adipate, Dimethicone Page 8 Sheetless hydrogel film comprising at least one selected from polyacrylate (Dimethicone PEG-8 Polyacrylate), and decyloxazolidinone (Decyloxazolidinone).
The method of claim 5, wherein the moisturizing agent
A sheetless hydrogel film comprising one or more selected from glycerin, sorbitol, and 1,3-butylene glycol.
delete delete The method according to claim 5, 6 or 7,
Indentation grooves and protrusions are formed on the surface in contact with the skin to form a reservoir of the active ingredient and moisture,
The sheetless hydrogel film, characterized in that the protrusion boundary line protruding from the surface of the dry film is formed at the boundary of the groove portion.
The method of claim 10, wherein the sheetless hydrogel film
The sheetless hydrogel film, characterized in that the groove portion and the projections are formed on both sides of the film.
delete delete Preparing a resin for a hydrogel;
Coating the hydrogel resin on a release film surface and then drying to form a hydrogel; And
Crosslinking and swelling the hydrogel by penetrating a crosslinking swelling agent into the hydrogel formed on the surface of the release film; Including;
The resin for the hydrogel is 1 to 40% by weight of a polymer resin containing a water-soluble polymer and natural polymer, 0.05 to 20% by weight sodium alginate, 0.1 to 20% by weight plasticizer, 0.1 to 20% by weight moisturizer and 20 to 98% by weight of distilled water Including;
The water-soluble polymer is polyvinyl alcohol (PVA) polyvinyl acetate / polyvinyl alcohol (PVAc / PVA), poly (N-vinyl pyrrolidone) (PVP), polyethylene oxide (PEO) and polyethylene oxide-polypropylene oxide copolymer (PEO-PPO, Pluronic series), one or more selected from
The natural polymer includes two or more selected from gelatin, facsimile, xanthan gum, glucomannan, guar gum and chitosan,
The crosslinking swelling agent includes 0.1 to 10% by weight of a compound containing at least one selected from Ca ²⁺ , Mg ²⁺ , Cu ²⁺ , Fe ²⁺ , Al ^3+, and Fe ³⁺ ,
The step of crosslinking and swelling is performed by impregnating a crosslinking swelling agent with a hydrogel formed on the surface of the release film or spraying a crosslinking swelling agent on the surface of the hydrogel formed on the surface of the release film.
The dried hydrogel has an average thickness of 20 μm to 100 μm, and the average thickness of the sheetless hydrogel film in which the hydrogel is swollen by a crosslinking swelling agent is 30 μm to 250 μm. Manufacturing method.
The method of claim 14 wherein the drying is
Method for producing a sheetless hydrogel film, characterized in that performed for 2 to 20 minutes at 50 ℃ ~ 90 ℃.
delete delete Cosmetic mask pack comprising a sheetless hydrogel film of claim 5.
A medical patch comprising the sheetless hydrogel film of claim 5.

Images