KR102038991B1 - A Restrainer for breeding or injection the tail vein of small animals - Google Patents

Abstract

The present invention relates to a correction device for tail vain injection or blood collection of small animals, assisting the blood collection from the tail after fixing laboratory animals, in particular a laboratory mouse used for various experiments. After placing laboratory animals on the top of a seating plate (100), the tail portion can be easily fixed separately for drug injection or extraction of the veins or arteries. In particular, the present invention not only can fix the laboratory animals very quickly and accurately, but also can easily fix the tail portion at about 90 degrees, and thus can improve the repeatability in the experimenter′s experiment and at the same time can increase the accuracy.

Description

A Restrainer for breeding or injection the tail vein of small animals}

The present invention relates to a small animal microvenous administration or blood collection correction device that assists the blood collection from the tail after fixing the experimental animal, in particular, the experimental rat used for various experiments, fixing the body of the experimental animal, the tail The present invention relates to a small animal intravenous administration or blood collection correction device that can be used for selectively inserting a needle into a vein or artery located in the blood vessel.

In general, intravenous injection has many advantages over other routes. Since the drug reaches the necessary tissues of the body through the heart within a few seconds, the drug appears quickly and the response is assured. It is used for replenishing water, salt, and other electrolytes when the water cannot be administered orally, or when injecting drugs such as an antidote into the blood or expecting fast medicinal effects.

Due to this feature, newly developed drugs or contrast agents are injected into experimental animals. In the field of new drug development and basic research, experimental animals are used for various purposes, and according to various research purposes and targets, various types of correction mechanisms for applying experiments to experimental animal models have been proposed.

Experimental rats of the above experimental animals are used a lot, in which case intravenous injection is essentially used, and the rat is usually held by one hand and injected into the tail by the other hand.

As disclosed in Korean Utility Model Registration No. 20-0329108, a laboratory rat has a thin and weak blood vessel and requires technical skill due to fluctuations in the tail, and it is difficult for one person to inject. Therefore, in the past, the auxiliary device was designed to fix the torso of the rat in the barrel, but there was a limit to the use of the rat by arranging the torso inside the barrel so that the tail vein was secured rather than conveniently and stably fixed. .

In addition, when drugs are injected into the arteries as well as the veins in the tail, it is difficult to identify and find the blood vessels of the arteries, which makes it difficult to secure precise experimental data.

Registered Utility Model No. 20-0329108 in Korea (Laboratory cradle for experimental rats. Registered on Sep. 26, 2003) 2. Korean Registered Patent Publication No. 10-1725639 (Auxiliary intravenous injection and blood collection aid of experimental rat, 2017.4.4.Registration) 3. Korean Patent Registration No. 10-1633560 (American Intravenous Injection and Blood Collection Aid of Laboratory Rat, 2016.06.20. Registration) 4. Japanese Registered Patent No. 3890491 (Animal Jacket, Registered May 26, 2006) 5. US Registered Patent US 9,510,783 (System for vascular access in laboratory animals, 2016.12.6. Registered)

The present invention has been made to solve the above problems, and stably fasten the body of the laboratory rat stably, and pull out only the tail portion by limiting the movement of the tail portion small animal vein administration or blood collection can be made precise injection It is an object to provide a correction device.

The present invention is a seating plate 100 is placed a test animal with a tail; A fixing part 200 coupled to the seating plate 100 to restrain the experimental animal placed on the seating plate 100; A position control unit 300 coupled to one side of the seating plate 100 to support the seating plate 100; And at least one guide plate 400 coupled to an upper surface of the position control unit 300 to determine and restrain the bending direction of the tail by an experimenter. It includes.

The seating plate 100 of the present invention may be coupled to be rotatable about a rotation shaft 110 coupled with the position control unit 300.

The seating plate 100 of the present invention further includes a rotation lever 120 provided with a tail insertion hole 121 to which the tail of the test animal is fixed, and the tail is rotated by the rotation lever 120. The predetermined angle can be rotated.

The position control unit 300 of the present invention may be hinged to the support arm 600 fixed to one side of the position control unit 300 to rotate by a predetermined angle relative to the ground.

The guide plate 400 of the present invention is the first guide plate 410 is fixed to the upper surface of the one side of the position control unit 300 and the tail arrangement is the first guide groove 440 to provide a first guide groove 440 The second guide plate 420 may be spaced apart from the plate 410 by a predetermined distance and fixed to the upper surface of the other side of the position controller 300.

In the lower portion of the first or second guide plate 410, 420 of the present invention, the first or second guide plate 410, to provide a second guide groove 450 for changing the direction of the tail The third guide plate 430 is spaced apart from the 420 by a predetermined distance and fixed to the upper surface of the other side of the position control unit 300.

The fixing part 200 of the present invention includes a jacket 210 to be coated on the body of the laboratory animal and the bore system 220 for bringing the jacket 210 into close contact with the seating plate 100 or the fixing part. 200 is coupled to the seating plate 100, may be a mold 230 for pressing the body of the laboratory animal.

The present invention can be precisely injected into the blood vessel when the drug is injected into the tail portion by restraining the body movement of the subject and minimize the movement of the tail portion, there is an advantage that the angle and height of the subject and the tail portion can be adjusted .

In addition, the present invention can easily find and inject the vein or arterial blood vessels of the tail due to the configuration of the specimen seat plate and the guide plate that can be rotated at an angle.

1 is a conceptual diagram illustrating an unintravenous blood collection system including a laboratory animal calibrating apparatus according to the present invention.
Figure 2 is a conceptual diagram showing an embodiment related to the guide plate of the experimental animal correction apparatus according to the present invention
Figure 3 is a conceptual diagram showing another embodiment related to the guide plate of the experimental animal correction apparatus according to the present invention
Figure 4 is a plan conceptual view showing another embodiment of the guide plate of the experimental animal correction apparatus according to the present invention
5 is a conceptual view related to the rotating lever of the experimental animal correction apparatus according to the present invention

The present invention will be described in detail with reference to the accompanying drawings.

1 is a general conceptual diagram of a microvenous blood collection or administration system. The experimental animal correction apparatus according to the present invention is shown to collect blood from the experimental animal fixed in the experimental animal correction apparatus according to the present invention, in particular, the rat vein. The near-infrared ray is irradiated to the upper side of the labia vein of the lab animal fixed to the lab animal calibrating device, and the position of the labia vein is accurately determined using an optical microscope. Using a digital camera connected to an optical microscope, the magnification can be confirmed by the experimenter through the digital viewer.

Near-infrared irradiator is used for thermal action and angiography, and by using optical microscope, the mouse's vein is magnified 10 to 100 times to check the position of the needle with a digital viewer (LCD screen), and the specific drug is applied to the vein. Administration or blood collection can be done.

Hereinafter, an experimental animal calibrating apparatus will be described in detail. A detailed description will be given with reference to FIGS. 1 to 3.

The present invention includes a seating plate 100, a fixing part 200, a position control part 300, a guide plate 400, and a heating part 500. Support arm 600 and base 700 for supporting and fixing them may be further included.

Referring to Figure 1, the base 700 is used for the purpose of supporting and placed on the ground or an experimental table. The support arm 600 for fixing the position control unit 300 and the like described above is fixed to the upper portion of the base 700. The support arm 600 may be fixed to be inclined at a predetermined angle with respect to the base 700 in consideration of the user's usability. The inclination may be arbitrarily designed in consideration of the convenience of the experimenter.

1 to 3, a position controller 300 or the like is provided at an upper portion of the support arm 600.

[Position control unit 300]

Referring to Figure 1, the position control unit 300 serves as a base to which the experimental animal is placed on the seating plate 100 to be described later. The position controller 300 may be hinged (not shown) with the aforementioned support arm 600 and tilted at a predetermined angle. That is, while adjusting the inclination of the position control unit 300 according to the propensity of the experimenter to determine the position of the vein, or to facilitate the experiment. In connection with the hinge, a variety of well-known techniques may be applied, and thus detailed descriptions are avoided.

[Guide Plate 400]

1 to 4, the guide plate 400 of the present invention will be described in detail.

The guide plate 400 is disposed on the upper surface of the position controller 300 described above. As illustrated, a plurality of regular or irregular holes or protrusions 310 may be disposed on the upper surface of the position controller 300. At the corresponding position, the guide plate 400 may also have a protrusion or hole 470. Alternatively, magnets may be provided in all or any one of them so that the guide plate 400 and the position controller 300 may be coupled to each other by a magnet. The above-described holes or protrusions 310 and 470 may facilitate the coupling between the guide plate 400 and the position controller 300 and may be a guide for the experimenter to determine the position for various purposes such as an experiment.

1 to 3, the guide plate 400 includes first to third guide plates 410, 420, and 430. The guide plate 400 formed of at least three or more plates may be naturally coupled to the upper surface of the position controller 300 to form first and second guide grooves 440 and 450. Inside the first and second guide grooves 440 and 450, the tail of the experimental animal is inserted and fixed.

In particular, referring to FIG. 3, the first guide plate 410 may be fixedly coupled to one half of the surface of the position controller 300. In another half-divided surface, the second guide plate 420 is fixed to the upper dividing surface, and the third guide plate 430 is fixed to the position controller 300 in the lower divided surface. The first and second guide grooves 440 and 450 as described above may be formed therebetween (see FIGS. 1 and 2). Alternatively, referring to FIGS. 3 and 4, the second guide groove 450 may be cut so that the ends of the second and third guide plates 420 and 430 have a 'base' (a) shape. The second guide groove 450 is naturally formed by the combination of the second and third guide plates 420 and 430. The tail of the experimental animal may be seated and fixed in the second guide groove 450.

On the other hand, as shown in Figures 2 and 4, the experimenter can change the position of the first to third guide plates (410, 420, 430) arbitrarily for the convenience of the experiment. In particular, the second and third guide plates 420 and 430 may be manufactured symmetrically. For this reason, the second and third guide plates 420 and 430 may be fastened to the position control unit 300 in the same shape or may be performed in the same shape even if they are inverted or moved left and right.

Referring to FIGS. 3 and 4, a pair of guide rollers 460 may be disposed in a portion bent from the first guide groove 440 to the second guide groove 450 so that the tail of the test animal can be firmly fixed. . Guide roller 460 may be composed of a core (461) and a louver (461) surrounding the core (461) around the shaft (462). The louver 461 is a portion in which the tail portion of the test animal is in contact, and may be formed of a material that does not slip, for example, rubber.

As shown in Figures 1 to 4, by using the configuration as described above, it is preferable to fix the tail in a bent state approximately 90 degrees to improve the accuracy of experiments such as accurate micro-vein check and blood collection.

In addition, since it is preferable to raise the tail portion in order to improve the accuracy of the experiment, it is preferable that the position control unit 300, the guide plates 400, 410, 420, and 430 be heated. To this end, the heating unit 500 is preferably provided between the position control unit 300 and the guide plates 400, 410, 420, and 430. Alternatively, the heating unit 500 may be provided inside the position control unit 300. That is, since the heating unit 500 has a purpose for raising the tail of the experimental animal, it may be anywhere if it is a position for raising the temperature.

[Seat plate 100]

1 to 3, the seating plate 100 is fixed to one side of the position control unit 300 to be rotatable. As shown in FIG. 3, the rotation shaft 110 is fixed to one side of the position controller 300. The experimental animal is rotated by rotating the seating plate 100 to which the body of the experimental animal is fixed. According to the rotation of the experimental animal, it is possible to accurately change the position of the vein or the artery.

Referring to Figure 5, one side of the seating plate 100 is provided with a rotary lever 120. The rotary lever 120 may be rotated alone or may be configured to be rotated integrally with the seating plate 100. Rotating shaft 110 is preferably provided in the substantially central portion of the rotary lever 110, the tail insertion hole 121 is located in the center upper side. Tail insertion hole 121 may be formed in a circular or semi-circular shape or the like. If only the rotary lever 120 is rotated independently it is desirable to form a semi-circular, not circular. That is, since only the tail can be twisted (rotated) during the independent rotation of the rotary lever 120, it may be possible to control the position of the micro-vein or the artery.

On the other hand, the position control unit 300 has a stopper 310 is provided to restrain the rotation degree of the rotary lever 120.

[Government (200)]

As shown in FIGS. 1 and 2, the fixing part 200 may include a jacket 210 and a bore system 220, or may include a mold 230.

1 and 2, after the jacket 210 is coated on the experimental animal, the experimental animal may be constrained to the seating plate 100 using the boa system 220. Here, the boa system 220 is a fastening form that is mainly used for shoes that are fastened according to the rotation of the fixed dial by using a fixed dial and a strap, so that detailed description thereof will be omitted. Alternatively, a string or the like is fastened to the jacket 210, and a part of the strap is constrained to the seating plate 100 so that the experimental animal is restrained in a state in which the jacket 210 is coated.

On the other hand, as shown in Figure 3, after the experimental animal is placed on the seating plate 100, the mold 230 may be fastened with the seating plate 100 while pressing the back portion of the test animal. The mold 230 may be formed of a mold formed of one mold, and the mold 230 and the fixing part 200 may be easily fastened and fixed using a magnet or the like.

Due to the above detailed description, after placing the experimental animal on the top of the seating plate 100, the tail portion may be easily fixed separately for blood vessel collection or drug injection of the vein or artery. In particular, not only can the animal be fixed very quickly and accurately, but also the tail can be easily fixed at about 90 degrees, thereby improving the repeatability in the experimenter's experiment and increasing the accuracy. .

100: mounting plate 200: fixing part
300: position control unit 400: guide plate
500: heating unit 600: support arm
700: base

Claims (7)

A seating plate 100 on which the tailed experimental animal is placed;
A fixing part 200 coupled to the seating plate 100 to restrain the experimental animal placed on the seating plate 100;
A position control unit 300 coupled to one side of the seating plate 100 to support the seating plate 100; And
The first guide plate 410 and the tail are coupled to an upper surface of the position control unit 300 and fixed to an upper surface of one side of the position control unit 300 so as to provide a first guide groove 440. One guide plate 410 is spaced apart from the predetermined distance by a second guide plate 420 is fixed to the other upper surface of the position control unit 300, at least one for the experimenter to determine the restraint direction of the tail Guide plate 400;
Small animal microvenous administration or blood collection correction device comprising a.
The method of claim 1,
The seating plate 100 is small animal vein administration or blood collection correction device, characterized in that coupled to the rotatable around the rotation axis 110 coupled with the position control unit 300.
The method of claim 1,
The seating plate 100 further includes a rotation lever 120 provided with a tail insertion hole 121 into which the tail of the test animal is inserted and fixed, and the tail rotates by a predetermined angle by the rotation of the rotation lever 120. Small animal microvenous administration or blood collection device, characterized in that the.
The method of claim 1,
The position control unit 300 is small animal vein administration or blood collection, characterized in that the hinge is coupled to the support arm 600 fixed to one side of the position control unit 300 to rotate by a predetermined angle relative to the ground Compensator.
delete The method of claim 1,
The first or second guide plates (410, 420) and the lower side of the first or second guide plates (410, 420) to provide a second guide groove 450 for changing the direction of the tail Small animal vein administration or blood collection device, characterized in that it comprises a third guide plate 430 which is spaced apart a predetermined distance fixed to the upper surface of the other side of the position control unit 300.
The method of claim 1,
The fixing part 200 includes a jacket 210 and a boa system 220 for bringing the jacket 210 into close contact with the seating plate 100.
The fixed part 200 is combined with the seating plate 100, small animal microvenous administration or blood collection correction device, characterized in that the mold 230 for pressing the body of the laboratory animal.

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