KR102015890B1 - Polysaccharide liquid crystal composition and manufacturing method thereof and cosmetic composition comprising the same - Google Patents

Abstract

The present invention relates to a polysaccharide liquid crystal composition, a method for manufacturing the same, and a cosmetic composition including the same, and more particularly, to stabilize a liquid lipid structure using a polysaccharide, a skin lipid complex and a natural moisturizing factor present in the stratum corneum of the skin. The present invention relates to a polysaccharide liquid crystal composition, a method for preparing the same, and a cosmetic composition including the same, which can be easily supported, excellent in stability, improve skin barrier, and replenish and maintain moisture on the skin.

Description

Polysaccharide liquid crystal composition, a manufacturing method and a cosmetic composition comprising the same {Polysaccharide liquid crystal composition and manufacturing method

The present invention relates to a polysaccharide liquid crystal composition, a method for manufacturing the same, and a cosmetic composition including the same, and more particularly, to stabilize a liquid lipid structure using a polysaccharide, a skin lipid complex and a natural moisturizing factor present in the stratum corneum of the skin. The present invention relates to a polysaccharide liquid crystal composition, a method for preparing the same, and a cosmetic composition including the same, which can be easily supported, excellent in stability, improve skin barrier, and replenish and maintain moisture on the skin.

Generally, skin is divided into three layers: epidermis, dermis and subcutaneous tissue. The epidermis in the outermost layer protects the skin from physical external damage, chemical external harmful substances and irritation, and prevents dryness of the skin by blocking and maintaining the evaporation of moisture in the human body.

To date, studies of lipid components in the stratum corneum have confirmed that the lamellar structure formed by the lipid component in the stratum corneum is the source of skin barrier function. In addition, although there are differences between skin tissues and individuals, the intracellular lipids are mostly composed of 40% ceramide, 25% cholesterol, and 25% free fatty acids, and other spings such as phytosphingosine, sphingosine, and sphinginin. It was found that there are a small amount of ring feeds (Non-Patent Document 1).

Ceramide, which occupies the most component in intercellular lipids, is arranged side by side in a stratum corneum in the stratum corneum and water is filled between them to maintain moisture, thereby forming a layered structure and thereby acting as a whole skin barrier function.

In addition, it was found that ceramide decomposes into phytosphingosine on the surface of the skin and acts as an antimicrobial barrier against harmful harmful microorganisms and plays an important role in controlling inflammation and wound healing. In many studies, ceramide has been found to be directly related to atopic dermatitis and other dermatological disorders. Ceramide and phytosphingosine have also been shown to be effective in treating atopic dermatitis.

In addition, the reduction of ceramide production due to genetic factors or aging decreases the protective barrier function of the stratum corneum, resulting in various dermatological symptoms such as atopic dermatitis and psoriasis symptoms (Non-Patent Documents 2 and 3). ).

On the other hand, the natural moisturizing factor present in the stratum corneum is composed of components such as amino acid, sodium pyrrolidone carboxylate, sodium lactate, urea, and the amino acid content is 40% of all natural moisturizing factors. Occupies.

Many studies have shown that the content of amino acids in atopic patients is significantly reduced compared to normal skin. That is, in people suffering from skin diseases such as atopic patients, skin lipid components and natural moisturizing factors present in the stratum corneum are reduced, which is easily damaged from external skin irritation, and moisture supply to the skin is not smooth. There is an urgent need to develop cosmetic materials that improve skin barrier and moisturize the skin.

(Non-Patent Document 1) J Chromato B Biomed Appl 1994, 656 (1): 65-71 (Non-Patent Document 2) Fulmer & Kramer, J. Invest. Derm., 86: 598-602 (1986) (Non-Patent Document 3) Tupker R. A. et al., Acta Derm. Venereol. Stockh, 70: 1-5 (1990)

The present invention has been made to solve the above problems, the object of the present invention is excellent stability, excellent moisturizing ability and skin barrier improvement effect, the skin lipid complex and the natural moisturizing factor using a polysaccharide liquid crystal structure The present invention is to provide a polysaccharide liquid crystal composition that can be stably supported, a method for preparing the same, and a cosmetic composition comprising the same.

These and other objects and advantages of the present invention will become more apparent from the following description of preferred embodiments.

The above object is achieved by a polysaccharide liquid crystal composition, wherein a liposome obtained by liposomes of a skin lipid complex and a polysaccharide are supported on a natural moisturizing factor liquid crystal base made of a natural moisturizing factor and a phospholipid. do.

Here, the skin lipid complex is characterized in that it comprises at least one of ceramide, sugar ceramide, phytosphingosine, cholesterol, stearic acid, palmitic acid.

Preferably, the polysaccharide comprises that at least one of albino mushroom polysaccharide, a hydrolyzed albino mushroom polysaccharide, a hydrolyzed albino mushroom spore capsule and extract, an albino mushroom spore capsule and extract, hyaluronic acid It features.

Preferably, the natural moisturizing factor is characterized in that it comprises serine, glycine, alanine.

Preferably, the phospholipid is characterized in that the hydrogenated phospholipid.

In addition, the above object, the first step of producing a skin lipid complex liposome by liposomes by liposomes by high pressure emulsification of the skin lipid complex, the second step of preparing a natural moisturizing factor liquid crystal base using a natural moisturizing factor and phospholipids, and the skin And a third step of supporting the liposome liposome and the natural moisturizing factor liquid crystal base on the polysaccharide.

Here, the third step includes a first step of mixing and stirring the skin lipid complex liposome and the natural moisturizing factor liquid crystal base, and a second step of adding polysaccharide and phospholipid to the mixed and stirred liquid in the first step Characterized in that.

Preferably, the phospholipid of the second stage is a hydrogenated phosphatidyl choline, and the phospholipid of the third stage is hydrogenated lecithin.

The above object is also characterized in that the liposome complexed skin lipid complex and phospholipid contain a natural moisturizing factor to form a primary liquid crystal emulsion, and then additionally add polysaccharide and phospholipid to form a secondary liquid crystal. It is achieved by a method for producing a polysaccharide liquid crystal composition.

Here, the phospholipid used when forming the primary liquid crystal emulsion is hydrogenated phosphatidyl choline, and the phospholipid used when forming the secondary liquid crystal is characterized by being hydrogenated lecithin.

In addition, the above object, 0.1 to 15% by weight of the polysaccharide liquid crystal composition in any one of astringent, softening, essence, cream, cleansing cream, cleansing lotion, cleansing foam, pack, shampoo, gel, body gel, body cleaner It is achieved by the cosmetic composition characterized by including.

According to the present invention, it is excellent in stability and can improve the skin barrier, and is effective in replenishing and maintaining the skin.

Furthermore, the present invention has the effect of stably supporting the skin lipid complex and the natural moisturizing factor present in the stratum corneum of the skin in a liquid crystal structure using polysaccharides.

However, the effects of the present invention are not limited to the above-mentioned effects, and other effects not mentioned will be clearly understood by those skilled in the art from the following description.

1 is an optical microscope image of a polysaccharide liquid crystal composition according to Example 1 of the present invention.
2 is a polarization microscope image of a polysaccharide liquid crystal composition according to Example 1 of the present invention.
3 is an optical microscope image of the polysaccharide liquid crystal composition according to Example 1 of the present invention after storage at 55 ° C. for 60 days.
4 is a polarized light microscope image after storing the polysaccharide liquid crystal composition according to Example 1 of the present invention at 55 ° C. for 60 days.
5 is a particle size analysis result of the skin lipid complex of the polysaccharide liquid crystal composition according to the preferred embodiment of the present invention.
6 is a graph of skin moisture retention (Hydration) of the emulsion cosmetic composition according to Example 7 and Comparative Example 4 of the present invention over time.
7 is a graph showing the rate of percutaneous moisture loss of the emulsion cosmetic composition according to Example 7 and Comparative Example 4 of the present invention.
8 is a schematic view of a liquid crystal in which a skin lipid complex and a natural moisturizing factor according to a preferred embodiment of the present invention are supported on a polysaccharide.

Hereinafter, the present invention will be described in detail with reference to embodiments and drawings of the present invention. These examples are only presented by way of example only to more specifically describe the present invention, it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples. .

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control. Also, although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described herein.

The polysaccharide liquid crystal composition according to an aspect of the present invention is a liposome-derived lipid lipid complex liposome and a natural moisturizing factor liquid crystal base made of a natural moisturizing factor and a phospholipid.

The skin lipid complex may include at least one of ceramide, sugar ceramide, phytosphingosine, cholesterol, stearic acid, and palmitic acid.

Ingredients such as ceramide, sugar ceramide, phytosphingosine, cholesterol, stearic acid and palmitic acid, which are present on the skin, have problems of precipitation after dissolution due to their structural characteristics, so that they can be deposited inside the liposome to maximize precipitation. It is important to prevent.

In addition, the polysaccharide may include at least one of the white agar mushroom polysaccharides, hydrolyzed albino mushroom polysaccharides, hydrolyzed albino mushroom spore capsules and extracts, the albino mushroom spore capsules and extracts, hyaluronic acid. Among them, the hydrolyzed cedar fungi and extracts are the same as Cas no and the polysaccharides. In addition, it was conventionally sold as "white mushroom mushroom spore sac and extract" but recently, it has been sold under the name "white mushroom mushroom polysaccharide".

Natural moisturizers may also include serine, glycine, alanine.

In addition, it is preferable to use hydrogenated phospholipid as the phospholipid which plays an important role in liquid crystal formation in the present invention. Generally, there are two kinds of phospholipids, unhydrogenated unsaturated phospholipids and hydrogenated stabilized hydrogenated phospholipids, which are widely used in the industry.However, unsaturated phospholipids are hardly dissolved in water and are not easy to manufacture. Since it can be issued, it is preferable to use hydrogenated phospholipid.

These phospholipids consist of substances such as phosphatidylcholine, phosphatidylethanolamine, phosphatidyl inositol, phosphatidylserine, and phosphatidyl acid. Among them, the liquid crystal forming ability varies depending on the content of phosphatidylcholine, and many efforts have been made to find a phospholipid applicable to the present invention.

To this end, Lecinol S-10 (Nikko chemicals) containing 20-25% of phosphatidylcholine (PC), Soya SPL 75H (Hydrogenated lecithin, Neuropid) containing 70-75% of PC, and PC content of 95% or more Experiments were carried out with raw materials of Lipoid S 100-3 (Hydrogenated phosphatidyl choline, lipoid GMBH). The experimental method was dissolved in 15 g of ethanol heated to 70 ° C. in 5% and 10% phospholipids, and water was added at 70 ° C. until the total capacity reached 100 g (w / w). It was carried out, it was observed by using a polarizing microscope whether Maltecs liquid crystal prepared.

As a result, the formulation prepared using Lecinol S-10 with PC content of 20-25% showed no liquid crystals in 5% and 10% phospholipids, and the formulation prepared using Soya SPL 75H used 5% phospholipids. A little liquid crystal was observed, and a lot of liquid crystal was observed when 10% of phospholipid was used. On the other hand, the formulation using lipoid S100-3 was confirmed that the liquid crystal is formed well even in the 5% phospholipid content.

The cosmetic composition comprising the polysaccharide liquid crystal composition according to another aspect of the present invention comprises the above-mentioned polysaccharide liquid crystal composition, astringent, softener, essence, cream, cleansing cream, cleansing lotion, cleansing foam, pack, shampoo, It may comprise 0.1 to 15% by weight of any one of gel, body gel, body cleaner.

According to another aspect of the present invention, there is provided a method for preparing a polysaccharide liquid crystal composition, wherein the lipid lipid complex is liposomed by high pressure emulsification to prepare a liposome skin lipid complex, and a natural moisturizing factor liquid crystal using a natural moisturizing factor and a phospholipid. A second step of preparing a base, and a third step of supporting the skin lipid complex liposomes and the natural moisturizing factor liquid crystal base on a polysaccharide.

Here, the third step includes a first step of mixing and stirring the skin lipid complex liposome and the natural moisturizing factor liquid crystal base, and a second step of adding polysaccharide and phospholipid to the mixed and stirred liquid in the first step can do.

The manufacturing method according to the present invention is completely different from the general manufacturing method of forming a liquid crystal using phospholipid and higher fatty acid alcohol in components such as ceramide, cholesterol and fatty acids which are skin lipid components. In other words, the preparation method according to the present invention first facilitates skin penetration by (nano) liposomal skin lipid components, and facilitates compatibility of skin lipid components and natural moisturizing factors in one formulation.

In addition, the maltecrose-type liquid crystals that are generally used in cosmetics have not been used widely in spite of their poor high temperature stability after preparation, even though their effects are superior to that of general emulsions. By supporting the natural moisturizing factor in one material and using polysaccharides, it is possible to maintain Maltech's liquid crystal structure for a long time, which improves the skin barrier to atopic dermatitis, psoriasis, dry skin, contact dermatitis and skin diseases. In addition, there is an excellent effect to replenish moisture inside the skin at the same time, it will also prevent skin diseases.

According to another aspect of the present invention, a method of preparing a polysaccharide liquid crystal composition includes a natural moisturizing factor in a liposome complexed skin lipid complex and a phospholipid to form a primary liquid crystal emulsion, and then additionally adds a polysaccharide and a phospholipid. To form a secondary liquid crystal.

In the present invention, the phospholipid used in forming the primary liquid crystal emulsion is hydrogenated phosphatidyl choline, and the phospholipid used in forming the secondary liquid crystal is preferably hydrogenated lecithin.

The phospholipid used in the formation of the primary liquid crystal emulsion has the highest PC content so that the liquid crystal is formed and maintained well, for example, the hydrogenated phosphatidyl choline is used. It is intended to have the effect of lowering the manufacturing cost by using a little low, for example, hydrogenated lecithin.

Thus, in the present invention, the components of the skin lipid membrane and the natural moisturizing factor are supported on polysaccharides to provide a liquid crystal composition having excellent precipitation and formulation stability, and at the same time improve skin barrier and supply and maintain moisture.

Hereinafter, the configuration and effects of the present invention will be described in more detail with reference to Examples and Comparative Examples. However, this embodiment is intended to illustrate the present invention in more detail, and the scope of the present invention is not limited to these examples.

EXAMPLE

Preparation Example 1 Preparation of Lipid Complex Liposomes for Skin

Skin lipid complexes such as ceramide, sugar ceramide, phytosphingosine, cholesterol, stearic acid and palmitic acid were selected, polyhydric alcohol is 1,3 butylene glycol, phospholipid is Lipoid S100-3, and nonionic surface which helps the stability of liposome. Using the sucrose fatty acid ester as an active agent, a skin lipid complex liposome was prepared in the following manner.

First, 5 g of ceramide, 0.3 g of sugar ceramide, 0.2 g of phytosphingosine, 1.0 g of cholesterol, 0.8 g of stearic acid, 0.7 g of palmitic acid, and 3 g of phospholipid were added to 50 g of 1,3 butylene glycol and warmed to 80-90 ° C. Dissolved. Next, 2 g of sucrose fatty acid ester was added to 37 g of water, dispersed, and warmed to 80 ° C. to dissolve. The dissolved two phases were emulsified at 3000 rpm using HOMO-Mixer, and then subjected to three times at 1000 bar using a high pressure emulsifier to prepare liposomes containing the skin lipid complex, and thus prepared liposomes were measured using a particle size analyzer. The average size was about 185 nm.

Preparation Example 2 Preparation of Natural Moisturizing Factor Liquid Crystal Base Using Natural Moisturizing Factor and Phospholipids

10 g of serine, 5 g of glycine, and 4 g of alanine were added to 76 g of warmed water at 90 ° C. and dissolved by stirring. While maintaining the aqueous amino acid solution in which serine, glycine, and alanine are dissolved at 90 ° C., 5 g of phospholipid (Lipoid S100-3) was slowly added thereto, and stirred at a speed of 4000 rpm using HOMO-Mixer to prepare a natural moisturizing factor liquid crystal base.

[Examples 1 to 6]

The liposome complex prepared in Preparation Example 1 was slowly added to the natural moisturizing factor liquid crystal base prepared in Preparation Example 2, which was maintained at a temperature of 50 ° C., mixed and stirred, followed by addition of polysaccharide and phospholipid (Soya SPL 75H). 10 minutes using HOMO Mixer 3000rpm to prepare a polysaccharide liquid crystal composition carrying a skin lipid complex and a natural moisturizing factor. The configurations used in these examples are shown in Table 1 below.

[Comparative Examples 1 to 3]

A liquid crystal composition was manufactured in the same manner as in Example 1, except that the composition shown in Table 1 was used.

Raw material Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 1 Comparative Example 2 Comparative Example 3 A Natural Moisturizing Factor LCD Base 70 70 70 70 70 70 70 70 87.5 B Skin Lipid Complex Liposomes 10 10 10 10 10 10 10 10 10 C Polysaccharides
(White mushroom polysaccharide) One 0.5 1.5 2 One One One _ _ B Hydrogenated lecithin 5 5 5 5 3 7 - 10 - C
Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 _ 1,2-hexanediol 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5

Physical properties of the liquid crystal compositions (emulsions) according to Examples 1 to 6 and Comparative Examples 1 to 3 were measured by the following experimental examples, and the results are shown below.

Immediately after the preparation of the liquid crystal emulsions according to the Examples and Comparative Examples, it was displayed on a 10-point scale according to the degree of formation of liquid crystals. One point represented that the particles were not well formed, and 10 points were excellent in liquid crystal formation. It is shown in Table 2 below.

Example
One Example
2 Example
3 Example
4 Example
5 Example
6 Comparative example
One Comparative example
2 Comparative example
3 Liquid crystal formation
The presence or absence 10 10 10 10 9 10 6 10 5

Next, in order to confirm the temperature stability of the liquid crystal composition (emulsion) according to Examples 1 to 6 and Comparative Examples 1 to 3, respectively, stored in a constant temperature bath at low temperature (4 ° C.), room temperature, and high temperature (45 ° C.) to observe stability. It was. To this end, each of the Examples and Comparative Examples were stored in a transparent container, and evaluated the stability visually at regular intervals, and the stability was expressed on a 10-point scale for maintaining the liquid crystal formation for clearer classification. In order to confirm the change in the initially generated liquid crystals, the initially generated liquid crystals were determined as 10 points, and stability experiments were performed for a total of 8 weeks. One point was expressed as the liquid crystal collapsed and the observation of the particles is not easy, and ten points are shown in Table 3 below as the retention of the formed liquid crystal is excellent.

Experiment item Example
One Example
2 Example
3 Example
4 Example
5 Example
6 Comparative example
One Comparative example
2 Comparative example
3 Low temperature
(4 ℃) 1 week 10 10 10 10 10 10 10 10 10 4 Weeks 10 10 10 10 10 10 10 9 8 8 Weeks 10 10 10 10 10 10 9 9 6 Room temperature
(25 ℃) 1 week 10 10 10 10 10 10 10 10 9 4 Weeks 10 10 10 10 10 10 9 8 6 8 Weeks 10 10 10 10 10 10 8 6 4 High temperature
(45 ℃) 1 week 10 10 10 10 10 10 9 6 4 4 Weeks 10 10 10 10 10 10 6 2 X 8 Weeks 10 9 10 10 9 10 4 X X

As can be seen from the results of Tables 2 and 3, the phospholipid plays an excellent role in the formation of the liquid crystal, it can be seen that the content of the polysaccharide is more important than the content of the phospholipid to maintain the liquid crystal.

Although the polysaccharide liquid crystal is formed in Comparative Example 1, since the phospholipid in the primary liquid crystal base containing the natural moisturizing factor is all of the total weight, the liquid crystal disappears as time passes at high temperature. In the case of the liquid crystal according to 6, the liquid crystal prepared by adding polysaccharide and phospholipid to the primary liquid crystal base containing the natural moisturizing factor was able to confirm excellent stability even at high temperature.

In addition, although there was no polysaccharide as in Comparative Example 2, the initial liquid crystal forming ability was most clearly generated due to the highest content of phospholipids. You can see that.

In addition, as in Comparative Example 3, if the polysaccharide and phospholipids are absent or insignificant, it can be confirmed that no liquid crystal is observed at high temperature.

Example 7

The cosmetic composition comprising the polysaccharide liquid crystal composition was prepared by adding the polysaccharide liquid crystal composition prepared in Example 1 and the composition of Table 4 below.

First, a carbomer was added to a water phase heated to 80 ° C. and dissolved by stirring. The oil phase was warmed to 80 ° C., stirred, and slowly added to the aqueous phase maintained at 75 ° C., and emulsified at 3000 rpm using a HOMO Mixer for 5 minutes. Thereafter, preservatives and neutralizers were sequentially added, followed by additional emulsification for 3 minutes using a HOMO Mixer. Thereafter, 3 wt% of the polysaccharide liquid crystal composition prepared in Example 1 was added to prepare an emulsion cosmetic composition.

[Comparative Example 4]

Except not using the polysaccharide liquid crystal composition prepared in Example 1 was added to the composition of Table 4 to prepare an emulsion cosmetic composition as in Example 7.

Raw material Example 7 Comparative Example 4 Awards Purified water to 100 to 100 glycerin 5 5 Carbomer 0.1 0.1 Paid Caprylic / Capric Triglycerides 5 5 Polysorbate 60 0.8 0.8 Glyceryl Stearate 0.5 0.5 antiseptic Phenoxyethanol 0.6 0.6 corrector Tromethamine 0.1 0.1 Example 1 3 _

Experimental Example 1 Measurement of Skin Water Retention Capacity

Skin moisture retention was measured using the emulsion cosmetic composition according to Example 7 and Comparative Example 4. 40 mg of the emulsion cosmetic composition according to Example 7 and Comparative Example 4 was applied to an area of human (N = 20 persons) with an area of 3 cm, respectively, and the skin moisturization was measured using a corneometer, and the average of the measured values was measured. Obtained is shown in Table 5 and FIG. In addition, the skin moisturizing state without applying the emulsion cosmetic composition is also shown for comparison.

0H 1H 3H 6H 24H Example 7 41.2 60.3 56.1 53.8 50.8 Comparative Example 4 41.1 51.4 47.3 45.6 44.1 No coating 41.2 41.1 41.2 41.2 41.1

As can be seen through Table 5, it can be seen that the water retention of the cosmetics to which the polysaccharide liquid crystal composition is added compared to the general emulsion cosmetics significantly increased. In general emulsion cosmetics (Comparative Example 4) compared to the initial increase in the skin moisturizing 7.3% compared to the polysaccharide liquid crystal (Example 1) added Example 7 it can be seen that the increase in the skin bosom 23.3%. Through this, it can be confirmed that the moisture retention of the cosmetic containing polysaccharide liquid crystal is superior to that of the general cosmetics.

Experimental Example 2 Measurement of Skin Barrier Improvement

In addition, the improvement of the skin barrier using the emulsion cosmetic composition according to Example 7 and Comparative Example 4. For this purpose, the emulsion cosmetic composition according to Example 7 and Comparative Example 4 was applied twice each morning and lunch for 11 subjects for a total of 4 weeks, and the transdermal moisture loss was measured using a Tewameter. Percutaneous water loss was commissioned by the Korean Institute of Dermatology, a specialized clinical research institution, the results are shown in Table 6 and FIG. Looking at this, it can be seen that the result of applying the emulsion cosmetic composition according to Example 7 is 31.6% better than before the test. The data in Table 6 is the measured value of TEWL of 11 subjects, and the average is converted into% improvement and tabulated in FIG. 7.

Example 7 Comparative Example 4 Before the test after 2 weeks 4 weeks later Before the test after 2 weeks 4 weeks later 19.8 19.5 10.2 15.9 16.3 11.6 11.9 9.9 6.2 9.8 8.4 7.5 15.6 14.6 10 15.0 15.0 11.2 18.4 18.3 12.8 13.4 15.5 14.8 15.1 13.2 11.5 16.1 15.0 14.5 9.1 8.6 6.4 8.9 10.2 8.1 13.4 11.3 10.0 12.2 12.4 9.4 11.6 10.6 10.2 11.7 10.7 10.8 10.7 11.1 7.7 8.7 10.6 8.4 9.4 8.0 7.0 9.2 10.0 8.5 11.5 10.9 8.3 12.6 11.6 9.4

* Changes in transdermal moisture loss (TEWL, g / ㎡ / hr) -Tewameter measurement

As described above, the polysaccharide liquid crystal composition loaded with the skin lipid complex and the natural moisturizing factor according to the present invention can improve skin moisture retention and can be seen as an effective material for improving skin barrier.

In the present specification, only a few examples of various embodiments performed by the present inventors are described, but the technical idea of the present invention is not limited thereto, but may be variously modified and implemented by those skilled in the art.

Claims (11)

The liposome complexed with the liposome complexed with the skin lipid complex is prepared using a natural moisturizing factor and a phospholipid, mixed with a primary liquid crystal emulsion containing a natural moisturizing factor in a phospholipid, and a polysaccharide and a phospholipid are further added. A polysaccharide liquid crystal composition, characterized in that the secondary liquid crystal formed by supporting on the ride. The method of claim 1,
The skin lipid complex is polysaccharide liquid crystal composition, characterized in that it comprises at least one of ceramide, sugar ceramide, phytosphingosine, cholesterol, stearic acid, palmitic acid. The method of claim 1,
The polysaccharide is characterized in that it comprises at least one of agaric mushroom polysaccharides, hydrolyzed albino mushroom polysaccharides, hydrolyzed albino mushroom spores and extracts, albino mushroom spores and extracts, hyaluronic acid, Polysaccharide liquid crystal composition. The method of claim 1,
The natural moisturizing factor is characterized in that it comprises a serine, glycine, alanine, polysaccharide liquid crystal composition. The method of claim 1,
The phospholipid is a hydrogenated phospholipid, polysaccharide liquid crystal composition. A first step of preparing the skin lipid complex liposome by liposomes by high pressure emulsification of the skin lipid complex,
A second step of preparing a primary liquid crystal emulsion containing a natural moisturizing factor in the phospholipid using a natural moisturizing factor and a phospholipid;
And a third step of preparing a secondary liquid crystal formed by mixing the skin lipid complex liposome with the primary liquid crystal emulsion and further adding polysaccharide and phospholipid to carry the primary liquid crystal emulsion on the polysaccharide. The manufacturing method of the polysaccharide liquid crystal composition. The method of claim 6,
The third step is a first step of mixing and stirring the skin lipid complex liposomes and the natural moisturizing factor liquid crystal base,
And a second step of adding polysaccharide and phospholipid to the mixed and stirred solution in the first step. The method of claim 7, wherein
The phospholipid of the second step is a hydrogenated phosphatidyl choline, the phospholipid of the third step is characterized in that the hydrogenated lecithin, a method for producing a polysaccharide liquid crystal composition. A polysaccharide liquid crystal composition, characterized in that the liposome complexed lipophilic complex and phospholipid contain a natural moisturizing factor to form a primary liquid crystal emulsion, and then additionally add polysaccharide and phospholipid to form a secondary liquid crystal. Manufacturing method. The method of claim 9,
The phospholipid used in forming the primary liquid crystal emulsion is a hydrogenated phosphatidyl choline, and the phospholipid used in forming the secondary liquid crystal is hydrogenated lecithin, characterized in that the method for producing a polysaccharide liquid crystal composition. The polysaccharide liquid crystal composition according to any one of claims 1 to 5 is used in astringent, softening, essence, cream, cleansing cream, cleansing lotion, cleansing foam, pack, shampoo, gel, body gel, body cleanser 0.1 to 15% by weight in any one, characterized in that the cosmetic composition.

Images