KR101998793B1

KR101998793B1 - 재조합 단순 헤르페스 바이러스의 제조를 위한 벡터

Info

Publication number: KR101998793B1
Application number: KR1020180105314A
Authority: KR
Inventors: 최경주; 김주항
Original assignee: 의료법인 성광의료재단
Priority date: 2018-09-04
Filing date: 2018-09-04
Publication date: 2019-07-10

Abstract

재조합 단순 헤르페스 바이러스 1형(HSV-1)을 제조하기 위한 벡터, 및 이의 용도에 관한 것이다. 일 양상에 따른 벡터를 이용하면 HSV-1의 당단백질 D 유전자 부위에 다양한 외래 유전자를 재조합 시킬 수 있으므로 HSV-1 조작을 용이하게 할 수 있고, 암세포 또는 종양세포에 특이적인 HSV-1를 제조할 수 있다.

Description

재조합 단순 헤르페스 바이러스의 제조를 위한 벡터{A vector for preparing recombinant herpes simplex virus}

재조합 단순 헤르페스 바이러스 1형(HSV-1)을 제조하기 위한 벡터, 및 이의 용도에 관한 것이다.

전세계적으로 암을 정복하기 위해 항암제의 개발 등 많은 연구가 이루어지고 있으나, 근본적인 치료는 이루어지지 않고 있다. 이를 위해 암세포만을 특이적으로 치료하기 위한 것이 표적 지향적 치료제이며, 바이러스 벡터를 사용함으로써 바이러스 자신의 유전자 조작을 통하여 유전자치료제로 개발할 수 있는 장점이 있다.

이와 관련하여, 2001년에 캐나다 캘거리 의과대학의 패트릭 리(Partick Lee) 연구진은 단순 헤르페스 바이러스 1형(Herpes Simplex Virus　1: HSV-1)이 암세포에 존재하는 발암 유전자(라스)의 변이에 의해 암에 대한 선택적 감염을 일으키고, 이를 통해 암세포를 사멸할 수 있음을 보고하였다. 헤르페스바이러스는 다른 바이러스벡터와 비교해서 삽입 유전자의 크기 제한이 없어 다양한 유전자를 삽입할 수 있는 장점을 갖는다. 그러나, 현재 개발된 대부분의 항암 HSV-1은 바이러스 복제에 필요한 유전자가 소실됨에 따라 바이러스 복제가 제한되어 그 치료 효능이 낮다는 한계점이 있다.

또한, HSV-1의 경우 152kb의 크기가 큰 DNA 바이러스이기 때문에 유전자 조작이 용이하지 않고 치료 유전자를 탑재하는데 기술적으로 어려움이 있다. 일반적으로 HSV-1 유전자를 조작하여 재조합 HSV-1을 제작하기 위해서는 대부분 삽입이나 치환을 원하는 유전자 부위를 PCR로 증폭하는데, PCR 수행 과정에서 치환되거나 삽입되는 서열에 돌연변이가 일어날 가능성이 있고, 서열의 GC 비율이 높은 경우 PCR 효율이 낮아서 재조합을 수행하기에 충분한 PCR 절편을 획득하기 어려운 단점이 있다.

따라서, 암에 대한 선택적 감염을 일으키는 HSV-1을 용이하게 재조합하기 위한 방법에 대한 연구가 필요하다.

암에 대한 선택적 감염을 일으키는 HSV-1의 유전자를 용이하게 재조합하기 위한 시스템에 관한 것으로, 재조합 HSV-1을 제조하기 위한 재조합 벡터, 재조합 HSV-1 및 이의 제조방법을 제공하고자 한다.

일 양상은 HSV-1 재조합을 위한 벡터를 제공한다.

본 발명의 일 양상에 따른 벡터는 HSV-1(Herpes Simplex Virus 1) 유래의 당단백질 D(glycoprotein D) 유전자 중 3' 영역이 결실되고 일부 영역이 암 표적 서열로 치환된 뉴클레오티드를 포함한다. HSV-1 유래의 당단백질 D 유전자 중 3' 영역이 결실되고, 일부 영역이 암 표적 서열로 치환된 재조합 HSV-1을 제조하기 위한 벡터 구조는 아직까지 보고된 바 없으므로, 본 발명의 일 양상에 따른 벡터는 신규한 구조의 재조합 벡터이다. HSV-1 유래의 당단백질 D 유전자 중 일부 영역이 암 표적 서열로 치환된 것이므로, HSV-1에 형질도입 시 우수한 효율로 상동 재조합이 가능하여 HSV-1의 당단백질 D를 암 표적 서열로 재조합할 수 있다.

본 명세서에서 "결실(deletion)"은 게놈 상에 존재하는 유전자를 제거하는 것을 의미한다. 예를 들어, 제한효소를 사용하여 유전자를 제거할 수 있다. 제한효소를 사용하는 유전자 클로닝 방법에 의해 전체 유전자를 제거하거나 유전자 뉴클레오티드 서열의 일부를 제거할 수도 있다. 상기 유전자 결실에 의해 유전자의 기능적 단백질의 발현이 일어나지 않거나 저해된다.

본 명세서에서 "치환(substitution)"은 게놈 상에 존재하는 유전자를 다른 유전자로 바꾸는 것을 의미한다. 예를 들어, 상동 재조합(homologous recombination)을 이용하여 유전자를 치환할 수 있다.

본 명세서에서 "벡터"는 적당한 숙주세포에서 목적 단백질 또는 목적 RNA를 발현할 수 있는 구조체로서, 유전자 삽입물이 발현되도록 작동가능하게 연결된 필수적인 조절요소를 포함하는 유전자 작제물을 말한다. 상기 벡터는 바람직하게는 유전자 삽입물이 발현되도록 작동가능하게 연결된 필수적인 조절요소를 포함하는 벡터일 수 있으며, 예를 들어 예를 들어, 플라스미드 벡터, 코즈미드 벡터 및 박테리오파아지 벡터, 아데노바이러스 벡터, 레트로바이러스 벡터 및 아데노-연관 바이러스 벡터와 같은 바이러스 벡터를 포함한다. 상기 벡터로 사용될 수 있는 벡터는 당업계에서 사용되는 플라스미드 (예를 들면, pSP72, pSC101, pGV1106, pACYC177, ColE1, pKT230, pME290, pBR322, pUC8/9, pUC6, pBD9, pHC79, pIJ61, pLAFR1, pHV14, pGEX 시리즈, pQE 시리즈, pBAD 시리즈, pET 시리즈 및 pUC19 등), 파지 (예를 들면, λgt4λB, λ-Charon, λΔz1 및 M13 등) 또는 바이러스 (예를 들면, CMV, SV40 등)를 조작하여 제작될 수 있다. 상기 벡터는 보다 바람직하게는 플라스미드 벡터일 수 있다.

상기 벡터는 암 표적 서열 발현을 위한 프로모터를 포함할 수 있다. 본 명세서에서 상기 "프로모터"는 적당한 숙주 세포에서 작동 가능하게 연결된 다른 핵산 서열의 발현을 조절하는 핵산 서열을 의미하며, 본 명세서에서 "작동가능하게 연결(operably linked)"은 일반적 기능을 수행하도록 핵산 발현조절 서열과 목적하는 단백질 또는 RNA를 코딩하는 핵산 서열이 기능적으로 연결(functional linkage)되어 있는 것을 말한다. 예를 들어 프로모터와 단백질 또는 RNA를 코딩하는 핵산 서열이 작동가능하게 연결되어 코딩서열의 발현에 영향을 미칠 수 있다. DNA 구조체 또는 벡터 내에서 프로모터의 작동적 연결은 당해 기술분야에서 잘 알려진 유전자 재조합 기술을 이용하여 제조할 수 있으며, 부위-특이적 DNA 절단 및 연결은 당해 기술 분야에서 일반적으로 알려진 효소 등을 사용한다. 원핵 세포를 숙주로 하는 경우에는, 전사를 진행시킬 수 있는 강력한 프로모터 (예를 들어, pLλ프로모터, trp 프로모터, lac 프로모터, tac 프로모터, T5 프로모터, T7 프로모터, PBAD 프로모터 등), 해독의 개시를 위한 라이보좀 결합 자리 및 전사/해독 종결 서열을 포함하는 것이 일반적이다. 진핵 세포를 숙주로 하는 경우에는, 벡터에 포함되는 진핵 세포에서 작동하는 복제원점은 f1 복제원점, SV40 복제원점, pMB1 복제원점, 아데노 복제원점, AAV 복제원점, CMV 복제원점 및 BBV 복제원점 등을 포함하나, 이에 한정되는 것은 아니다. 또한, 포유동물 세포의 게놈으로부터 유래된 프로모터 (예를 들어, 메탈로티오닌 프로모터) 또는 포유동물 바이러스로부터 유래된 프로모터 (예를 들어, 아데노바이러스 후기 프로모터, 백시니아 바이러스 7.5K 프로모터, SV40 프로모터, 사이토메갈로바이러스 (CMV) 프로모터 및 HSV의 tk 프로모터)가 이용될 수 있으며, 전사 종결 서열로서 폴리아데닐화 서열을 일반적으로 갖는다.

상기 벡터는 항생제 저항성 영역, 또는 복제원점을 포함할 수 있다.

본 명세서에서 "단순 헤르페스 바이러스(Herpes Simplex Virus: HSV)"는 헤르페스비리데(Herpesviridae)과에 속하는 바이러스로, 단순 헤르페스 바이러스 1형(Herpes Simplex Virus type 1: HSV-1) 및 단순 헤르페스 바이러스 2형(Herpes Simplex Virus type 2: HSV-2)으로 구분된다. HSV-1은 인간 헤르페스 바이러스 1형(Human Herpes Virus type 1: HHV-1)이라고도 한다. HSV-1의 핵산은 이중가닥의 선형 DNA이다. 따라서, HSV-1의 게놈은 이중가닥 선형 DNA로 구성된 것일 수 있다. HSV-1의 게놈 서열은 공지된 HSV-1 균주(strain)의 게놈 서열이라면, 그 종류를 제한하지 않는다. HSV-1 게놈의 예시적인 서열은 NCBI GenBank Accession No. JQ673480.1에 기재되어 있다. 본원에서 별다른 개시가 없는 한 "HSV-1"은 "야생형 HSV-1"와 상호교환적으로 사용되며, 일 양상에 따른 "재조합 HSV-1"와 구별된다.

본 명세서에서 "당단백질 D(glycoprotein D: gD)" 유전자는 HSV-1 유래일 수 있다. 헤르페스 바이러스에는 11개의 알려진 항원적으로 구별되는 당단백질이 있다: gB, gC, gD, gE, gG, gI, gH, gJ, gK, gL, 및 gM. 이들 당단백질들은 HSV 감염시 체액성(humoral) 면역 반응의 타겟(target)이며 일차적인 유도인자(inducer)이고, 세포 매개(cell-mediated) 면역반응의 주요한 유도인자이고 타겟들이다. 이들 중, HSV-1이 숙주세포에 감염되기 위해서는 당단백질 C와 당단백질 D가 주요하게 관여한다. 당단백질 C는 헤파린 설페이트와 결합하여 세포 표면의 필로포디아(filopodia)에 결합한 후 세포로 이동하는데 작용한다. 당단백질 D는 주요 수용체 결합 단백질로, HSV-1이 세포표면에 발현되는 HVEM(gerpesvirus entry mediator), 넥틴-1, 또는 3-O 설페이티드 헤파란 설페이트(3-O-sulfated heparan sulfate: 3-OS-HS)를 포함하는 세포 수용체에 특이적으로 결합하여 구조적 변화를 유도한다. 구조적 변화에 따라 융합 단백질인 당단백질 H/L과 결합하게 된다. 이후 당단백질 B에 의해 숙주세포막과 HSV-1의 껍질(envelope)이 서로 융합하여 HSV-1이 숙주세포 내로 이동하게 되는 것이다.

상기 당단백질 D 유전자는 서열번호 1의 뉴클레오티드 서열에서 138,279 내지 139,463 번째 서열을 가질일 수 있다. 상기 당단백질 D 유전자는 당단백질 D 유전자의 기능을 변형하지 않는 범위에서 약 200 nt 길이의 범위, 예를 들어, 약 10 내지 200 nt, 약 20 내지 150 nt, 약 30 내지 120nt, 약 40 내지 110 nt, 약 50 내지 100 nt, 약 60 내지 90 nt, 약 70 내지 80 nt, 또는 약 75 nt 길이의 뉴클레오티드를 더 포함할 수 있다. 상기 더 포함될 수 있는 뉴클레오티드는 예를 들어 서열번호 1의 뉴클레오티드 서열에서 138,204 내지 138,278 번째 서열을 포함할 수 있으나, 이는 벡터 제작의 편의를 위하여 당업자에 의해 바람직한 서열로 선택될 수 있다.

상기 결실된 3' 영역은 서열번호 1의 뉴클레오티드 서열 중 138,837 내지 139,463번째 서열일 수 있다.

상기 암 표적 서열로 치환된 일부 영역은 서열번호 1의 뉴클레오티드 서열 중 138,354 내지 138,510 번째 서열일 수 있으나, 이에 제한되는 것은 아니다

상기 치환된 일부 영역은 HVEM(gerpesvirus entry mediator), 넥틴-1(nectin-1), 및/또는 3-O 설페이티드 헤파란 설페이트(3-OS-HS)에 결합하여 HSV-1이 세포에 감염하도록 유도하는 역할을 수행할 수 있다. 따라서, 상기 일부 영역을 암 표적 서열로 치환함으로써 HVEM, 넥틴-1, 3-O 설페이티드 헤파란 설페이트 매개된 HSV-1의 감염 효율이 감소하나, 상기 일부 영역이 암 표적 서열로 치환되기 때문에, 결과적으로 암 표적 서열에 의해 HSV-1의 숙주 세포로의 감염 효율이 증가한다.

상기 암 표적 서열과 당단백질 D는 링커로 연결된 것일 수 있다. 상기 링커는 유연성(flexibility)을 갖는 서열이라면 이에 제한되는 것은 아니나, 글리신 풍부 서열을 포함할 수 있고, 예를 들어 서열번호 2의 서열을 포함할 수 있다.

상기 벡터는 암 표적 서열을 포함한다. 본 명세서에서 "암 표적 서열"은 암세포 또는 종양세포를 특이적으로 표적할 수 있는 임의의 서열이라면 제한 없이 포함할 수 있다. 예를 들어, 상기 암 표적 서열은 EGFRvⅢ(epidermal growth factor receptor variant Ⅲ), EGFR, FGFR, 인테그린(integrin), EpCAM, HMWMAA 수용체, CD40, PSMA, VEGFR2, Tie2, 엽산 수용체(Folate receptor), 난포자극호르몬수용체(follicle stimulating hormone recptor), 엽산(folic acid), 뉴로필린 수용체(neuropilin receptor), 및 트랜스페린 수용체(transferrin receptor)로 구성된 군으로부터 선택된 1종 이상서열을 포함할 수 있다. 상기 서열은 펩티드 서열, 리간드, Fab, 또는 scFv 서열일 수 있다.당단백질 D의 일부 영역이 암 표적 서열로 치환됨으로써, 상기 벡터를 야생형 당단백질 D 유전자를 가진 (토탈)벡터와 숙주세포에 함께 형질도입할 때 암 표적 서열이 포함된 당단백질 D 서열과 야생형 당단백질 D 유전자를 가진 토탈벡터와 상동 재조합을 일으킴으로써 토탈벡터에 암 표적 유전자가 포함될 수 있다. 이러한 암 표적 서열에 의해 토탈벡터의 암 표적능을 보유하게 되는 효과가 있다. 즉, 암 표적 서열은 이런 암 표적능을 재조합 HSV-1에 부여할 수 있는 서열이라면 어떠한 서열이라도 가능하다.

다른 양상은 HSV-1 유래의 당단백질 D 유전자 중 3' 영역이 결실되고 일부 영역이 암 표적 서열로 치환된 뉴클레오티드를 포함하는 벡터를 제조하는 단계; 및 상기 벡터를 세포에 형질도입하여 재조합 HSV-1을 수득하는 단계를 포함하는 재조합 HSV-1을 제조하는 방법을 제공한다.

상기 방법에서 상기 재조합 HSV-1은 HSV-1 게놈 중 당단백질 D 유전자 영역이 재조합된 것으로, 형질도입 시 암 표적 서열이 세포의 당단백질 D 유전자와 상동 재조합된 것일 수 있다.

본 명세서에서 "상동 재조합(homologous recombination)"은 매우 유사한 긴 염기서열 간에 일어나는 것을 지칭한다. 여러　유전자　교환방식을 통해 새로운　DNA　분자가 세포 내로 유입될 때 필요한 현상이다. 일단 외부의　DNA가 세균 내로 들어가면　DNA　형태에 따라 다른 형태로 세포 내 보존된다. 이 것이 독립적인 복제가 가능하여　염색체와 공존할 수 있는　플라스미드의 경우도 있지만, 스스로 복제능력이 없는　DNA인 경우라면 유전자 재조합을 통해 염색체 내로 삽입된 상태로 유지할 수밖에 없다. 이렇게 염색채 내로 삽입되기 위해서 상동 재조합이 일어난다.

상기 방법은 HSV-1 유래 당단백질 D 유전자 중 일부 영역을 암 표적 서열로 치환한 뉴클레오티드를 포함하는 벡터를 셔틀 벡터로 사용하여, 상기 셔틀 벡터가 숙주세포로 유입될 때 상기 셔틀 벡터에 포함된 당단백질 D 서열과 유사한 특징을 이용하여 당단백질 D 및 암 표적 서열을 상동 재조합을 통해 염색체 내로 삽입하는 것을 목적으로 한다.

상기 벡터를 세포에 형질도입시키는 방법은 당업계에 공지된 다양한 방법을 통하여 수행할 수 있다. 예를 들어, 미세 주입법(Capecchi, M.R., Cell, 22:479(1980); 및 Harland와 Weintraub, J. Cell Biol. 101:1094-1099(1985)), 칼슘 포스페이트 침전법(Graham, F.L. et al., Virology, 52:456(1973); 및 Chen과 Okayama, Mol. Cell. Biol. 7:2745-2752(1987)), 전기 천공법(Neumann, E. et al., EMBO J., 1:841(1982); 및 Tur-Kaspa et al., Mol. Cell Biol., 6:716-718(1986)), 리포좀-매개 형질감염법(Wong, T.K. et al., Gene, 10:87(1980); Nicolau 및 Sene, Biochim. Biophys. Acta, 721:185-190(1982); 및 Nicolau et al., Methods Enzymol., 149:157-176(1987)), DEAE-덱스트란 처리법 (Gopal, Mol. Cell Biol., 5:1188-1190(1985)), 및 유전자 밤바드먼트(Yang et al., Proc. Natl. Acad. Sci., 87:9568-9572(1990)) 방법에 의해 벡터를 세포에 형질감염시킬 수 있다.

다른 양상은 상기 방법에 따라 제조된 재조합 HSV-1을 제공한다.

상기 재조합 HSV-1은 암 세포 또는 종양세포 특이성을 나타내는 것일 수 있다. 즉, 상기 재조합 HSV-1은 암살상바이러스(oncolytic virus)인 것일 수 있다. 용어 "암살상바이러스"는 "암용해바이러스", "항암 바이러스"와 상호교환적으로 사용된다. 상기 암살상바이러스는 암세포 또는 종양세포를 특이적으로 사멸시킴으로써 암세포의 항원을 노출시켜 면역 세포를 활성화시킬 수 있다. 따라서, 암살상바이러스는 그 자체로 항암 용도로 사용할 수 있으며, 다른 항암제와 병용하여 항암 효과를 증진시킬 수도 있다. 또한, 암살상바이러스 벡터에 다양한 치료 유전자를 삽입하여 항암 효과를 증진시킬 수 있다.

다른 양상은 상기 재조합 HSV-1을 포함하는 약학적 조성물을 제공한다.

상기 재조합 HSV-1은 상술한 바와 같다.

상기 약학적 조성물은 항암용 약학적 조성물일 수 있다.

상기 "암(cancer)"은 세포가 정상적인 성장 한계를 무시하고 분열 및 성장하는 공격적(aggressive) 특성, 주위 조직에 침투하는 침투적(invasive) 특성 및 체내외 다른 부위로 퍼지는 전이적(metastatic) 특성을 갖는 세포에 의한 질병을 총칭한다. 상기 암은 악성 종양(malignant tumor) 혹은 종양(tumor)과 동일한 의미로 사용되며, 고체 종양 및 혈액 종양(blood born tumor)을 포함할 수 있다. 상기 암은 그 종류를 한정하지 않는다.

상기 약학적 조성물은 기존의 암 치료 물질(예: 항암제)과 병용되어 암의 치료 효능을 향상시킬 수 있다. 상기 항암제는 대사길항제, 알킬화제, 토포아이소머라제 길항제, 미세소관 길항제, 항암 항생제, 식물유래 알칼로이드, 항체 항암제 또는 분자표적 항암제일 수 있고, 보다 구체적으로, 탁솔, 나이트로젠 머스타드, 이마티닙, 옥살리플라틴, 리툭시맙, 엘로티닙, 트라스투주맙, 제피티닙, 보르테조밉, 수니티닙, 카보플라틴, 소라페닙, 베바시주맙, 시스플라틴, 세툭시맙, 비스쿰알붐, 아스파라기나제, 트레티노인, 하이드록시카바마이드, 다사티닙, 에스트라머스틴, 겜투주맵오조가마이신, 이브리투모맙튜세탄, 헵타플라틴, 메칠아미노레불린산, 암사크린, 알렘투주맙, 프로카르바진, 알프로스타딜, 질산홀뮴 키토산, 젬시타빈, 독시플루리딘, 페메트렉세드, 테가푸르, 카페시타빈, 기메라실, 오테라실, 아자시티딘, 메토트렉세이트, 우라실, 시타라빈, 플루오로우라실, 플루다라빈, 에노시타빈, 데시타빈, 머캅토푸린, 티오구아닌, 클라드리빈, 카르모퍼, 랄티트렉세드, 도세탁셀, 파클리탁셀, 이리노테칸, 벨로테칸, 토포테칸, 비노렐빈, 에토포시드, 빈크리스틴, 빈블라스틴, 테니포시드, 독소루비신, 이다루비신, 에피루비신, 미톡산트론, 미토마이신, 블레오마이신, 다우노루비신, 닥티노마이신, 피라루비신, 아클라루비신, 페플로마이신, 테모졸로마이드, 부설판, 이포스파미드, 사이클로포스파미드, 멜파란, 알트레트민, 다카바진, 치오테파, 니무스틴, 클로람부실, 미토락톨, 로무스틴 및 카르무스틴일, 이매티닙, 게피티닙, 에르토티닙, 트리스투주맙, 로실레티닙, 네시투무맙, 에버롤리무스, 라무시루맙, 다코미티닙, 포레티닙, 팸브롤리주맙, 이필리무맙, 니볼루맙, 다브라페닙, 벨리파립, 세리티닙, 카무스틴, 시클로포스파미드, 이포스파마이드, 익사베필론, 멜팔란, 메르캅토푸린, 미토산트론, 또는 티에스원일일 수 있으나, 이에 한정되지 않는다.

상기 조성물은 면역 관문 억제제(Immune checkpoint inhibitor)와 동시에, 별도로, 또는 순차적으로 병용 투여될 수 있다. 상기 "면역 관문"은 면역세포 표면에서 면역 반응의 자극 또는 억제 신호를 유발하는데 관여하는 단백질을 총칭하며, 암세포는 이러한 면역 관문을 통해 면역반응의 자극 및 이에 따른 암세포의 억제가 제대로 진행되지 않도록 조작하여 면역체계의 감시망을 회피하게 되며, 즉, 항종양 면역반응을 무력화시킨다. 상기 면역 관문 억제제는 PD-1(programmed cell death-1), PD-L1(programmed cell deathligand 1), PD-L2(programmed cell death-ligand 2), CD27(cluster of differentiation 27), CD28(cluster of differentiation 28), CD70(cluster of differentiation 70), CD80(cluster of differentiation 80; B7-1로도 알려짐), CD86(cluster of differentiation 86; B7-2로도 알려짐), CD137(cluster of differentiation 137), CD276(cluster of differentiation 276), KIRs(killer-cell immunoglobulin-like receptors), LAG3(lymphocyte-activation gene 3), TNFRSF4(tumor necrosis factor receptor superfamily, member 4; CD134로도 알려짐), GITR(glucocorticoid-induced TNFR-related protein), GITRL(glucocorticoid-induced TNFR-related protein ligand), 4-1BBL(4-1BB ligand), 및 CTLA-4(cytolytic T lymphocyte associated antign-4) 길항제 중 하나 이상을 포함할 수 있으나, 이에 한정되지 않는다.

상기 약학적 조성물은 약학적으로 허용가능한 담체 또는 희석제를 더 포함할 수 있다. 약학적으로 허용가능한 담체 또는 희석제는 당업계에 알려진 것일 수 있다. 상기 담체 또는 희석제는 락토스, 덱스트로스, 수크로스, 솔비톨, 만니톨, 전분, 아카시아 고무, 인산 칼슘, 알기네이트, 젤라틴, 규산 칼슘, 미세결정성 셀룰로스, 폴리비닐피롤리돈, 셀룰로스, 물(예를 들면, 식염수 및 멸균수), 시럽, 메틸 셀룰로스, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 활석, 스테아르산 마그네슘, 미네랄 오일, 링거액, 완충제, 말토덱스트린 용액, 글리세롤, 에탄올, 덱스트란, 알부민, 또는 이들의 임의의 조합일 수 있다. 상기 약학적 조성물은 윤활제, 습윤제, 감미제, 향미제, 유화제, 현탁제, 또는 보존제를 더 포함할 수 있다.

상기 약학적 조성물은 당업자에게 알려진 방법에 따라, 약제학적으로 허용되는 담체 및/또는 부형제를 이용하여 제제화함으로써 단위 용량 형태로 제조되거나 또는 다용량 용기 내에 내입시켜 제조될 수 있다. 이때 제형은 오일 또는 수성 용매 중의 용액, 현탁액, 시럽제 또는 유화액 형태이거나 엑스제, 산제, 분말제, 과립제, 정제 또는 캅셀제 형태일 수 있고, 분산제 또는 안정화제를 추가적으로 포함할 수 있다. 상기 수성 용매는 생리식염수 또는 PBS를 포함하는 것일 수 있다. 일 구체예에 따른 상기 약학적 조성물은 경구 또는 비경구 투여 형태, 바람직하게는 비경구 투여 형태로 제제화될 수 있다. 근육내, 복강내, 피하 및 정맥내 투여 형태의 경우, 통상적으로 활성 성분의 멸균 용액을 제조하고, 용액의 pH를 적합하게 조절할 수 있는 완충제를 포함할 수 있으며, 정맥내 투여의 경우 제제에 등장성이 부여되도록 등장화제를 포함할 수 있다.

상기 약학적 조성물의 투여량(유효량)은 제제화 방법, 투여 방식, 환자의 연령, 체중, 성별, 병적 상태, 음식, 투여 시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하게 처방될 수 있고, 당업자라면 이러한 요인들을 고려하여 투여량을 적절히 조절할 수 있다. 가능한 투여 경로에는 비경구 (예를 들어, 피하, 근육내, 동맥내, 복강내, 경막내, 또는 정맥내), 국소 (경피 포함), 및 주사, 또는 이식성 장치 또는 물질의 삽입을 포함할 수 있다. 일 구체예에 따른 치료의 대상동물로서는, 인간 및 그 밖의 목적으로 하는 포유동물을 예로 들 수 있고, 구체적으로는 인간, 원숭이, 마우스, 래트, 토끼, 양, 소, 개, 말, 돼지 등이 포함된다. 상기 조성물은 단독으로, 또는 외과적 수술요법 등의 보조 치료 방법들과 병행하여 사용할 수 있다. 상기 조성물과 함께 이용될 수 있는 화학 요법제(chemotherapeutic agent)는 시스플라틴(cisplatin), 카르보플라틴 carboplatin), 프로카르바진(procarbazine), 메클로레타민(mechlorethamine), 시클로포스파미드(cyclophosphamide), 이포스파미드 (ifosfamide), 멜팔란(melphalan), 클로라부실(chlorambucil), 비술판(bisulfan), 니트로소우레아 (nitrosourea), 디악티노마이신(dactinomycin), 다우노루비신(daunorubicin), 독소루비신(doxorubicin), 블레오마이신(bleomycin), 플리코마이신(plicomycin), 마이토마이신(mitomycin), 에토포시드(etoposide), 타목시펜(tamoxifen), 택솔(taxol), 트랜스플라티눔(transplatinum), 5-플루오로우라실(5-fluorouracil), 빈크리스틴(vincristin), 빈블라스틴(vinblastin) 및 메토트렉세이트(methotrexate) 등을 포함할 수 있다.

상기 조성물과 함께 이용될 수 있는 방사 요법은 X-선 조사 및 γ -선 조사 등이다.

다른 양상은 개체에 상기 재조합 HSV-1, 또는 상기 재조합 HSV-1을 포함하는 약학적 조성물의 유효량을 투여하는 단계를 포함하는 암세포 또는 종양세포 생존능을 저해하는 방법을 제공한다. 상기 방법은 암 치료 방법일 수 있다.

용어 "치료"는 질환, 장애 또는 병태, 또는 그의 하나 이상의 증상의 경감, 진행 억제 또는 예방을 지칭하거나, 그를 포함하며, "유효성분" 또는 "약제학적 유효량"은 질환, 장애 또는 병태, 또는 그의 하나 이상의 증상의 경감, 진행 억제 또는 예방에 충분한 본원에서 제공되는 발명을 실시하는 과정에서 이용되는 조성물의 임의의 양을 의미할 수 있다.

용어, "투여하는", "도입하는", 및 "이식하는"은 상호교환적으로 사용되고 일 구체예에 따른 조성물의 원하는 부위로의 적어도 부분적 국소화를 초래하는 방법 또는 경로에 의한 개체내로의 일 구체예에 따른 조성물의 배치를 의미할 수 있다. 일 구체예에 따른 조성물의 유효성분을 생존하는 개체 내에서 원하는 위치로 전달하는 임의의 적절한 경로에 의해 투여될 수 있다. 개체 투여 후 세포의 생존 기간은 짧으면 수 시간, 예를 들면 24시간 내지 수일 내지 길면 수년일 수 있다.

일 양상에 따른 벡터를 이용하면 HSV-1의 당단백질 D 유전자 부위에 다양한 외래 유전자를 재조합 시킬 수 있으므로 HSV-1 조작을 용이하게 할 수 있고, 암세포 또는 종양세포에 특이적인 HSV-1를 제조할 수 있다.

도 1은 야생형 HSV-1(Wt-HSV-1)의 모식도이다.
도 2는 pBSKII SK(-)-gD-5' 플라스미드의 모식도이다.
도 3은 pBSKII SK(-)-gD-5' 플라스미드의 클로닝 여부를 검증하기 위한 전기영동 수행 결과이다.
도 4는 pSP72-gD-5' 플라스미드의 모식도이다.
도 5는 pSP72-gD-5' 플라스미드의 클로닝 여부를 검증하기 위한 전기영동을 수행한 결과이다.
도 6은 EGVRvIII scFv 유전자와 NcoI-gD-6B5 linker 센스 프라이머 및 NcoI-gD-6B5 linker 안티센스 프라이머의 위치를 나타낸 모식도이다.
도 7은 당단백질 D 유전자와 Linker-gD-BssHII 센스 프라이머 및 Linker-gD-BssHII 안티센스 프라이머의 위치를 나타낸 모식도이다.
도 8은 EGFRvIII scFv와 당단백질 D가 링커로 연결되었는지 확인하기 위해 PCR 산물을 전기영동한 사진이다.
도 9는 pSP72-gD-5'-scFv의 모식도이다.
도 10은 pSP72-gD-5'-scFv 클로닝 여부를 검증하기 위한 전기영동 결과이다.

이하 실시예를 통하여 보다 상세하게 설명한다. 그러나, 이들 실시예는 하나 이상의 구체예를 예시적으로 설명하기 위한 것으로 본 발명의 범위가 이들 실시예에 한정되는 것은 아니다.

실시예 1. HSV -1 유래 당단백질 D 유전자에 암 표적 서열인 EGFRvIII에 대한 scFv가 치환된 재조합 벡터의 제작

HSV-1 유래 당단백질 D 유전자를 포함하는 재조합 벡터를 제작하고, 이를 검증하였다.

도 1은 야생형 HSV-1(Wt-HSV-1)의 모식도이다.

야생형 HSV-1은 양쪽에 terminal repeat region(TR)으로 둘러싸여 있으며 internal repeat(IR) region에 의해 unique long(U_L) 영역과 unique short(U_S) 영역으로 구분된다. 야생형 HSV-1은 총 3개의 복제원점(ori site)를 가지며 U_L 위치에 한 개(L) U_S위치에 2개(S)가 있다. 당단백질 D는 HSV-1의 138,279 번째 서열부터 139,463 번째 서열까지의 1185 bp의 크기를 갖는 유전자이다.

먼저, 야생형 HSV-1의 게놈 서열에서 제한효소 HindIII, NaeI을 사용하여 HSV-1 게놈 영역 중 138,204 내지 138,836 번째 뉴클레오티드를 절단하여 632bp 크기의 5' 쪽의 당단백질 D 유전자 절편(이하 gD-5')을 획득하였다. 상기 야생형의 HSV-1 게놈 서열에서 138,204 내지 138,836 번째 뉴클레오티드는 당단백질 D의 3' 영역이 결실된 일부 영역에 해당한다.

다음, 상기 5' 영역의 당단백질 D 유전자 절편을 제한효소 HindIII와 SmaI으로 절단한 벡터 pBluescript II SK (-)에 삽입하여 pBSKII SK(-)-gD-5' 플라스미드를 제작하였다.

도 2는 pBSKII SK(-)-gD-5' 플라스미드의 모식도이다.

클로닝 여부를 검증하기 위해서, 상기 pBSKII SK(-)-gD-5' 플라스미드를 제한효소 PvuII로 절단한 후 전기영동을 수행하였다.

도 3은 pBSKII SK(-)-gD-5' 플라스미드의 클로닝 여부를 검증하기 위한 전기영동 수행 결과이다.

도 3에 나타낸 바와 같이, 대조군인 pBSKII(-) 자체는 제한효소 처리에 의해 445bp, 2513bp의 크기의 밴드를 보인 반면, pBSKII(-)-gD-5'는 제한효소 처리에 의해 338bp, 664bp, 2513bp의 크기의 밴드를 보였으므로, gD-5'에 대한 클로닝이 성공적으로 수행되었음을 검증하였다.

다음, HSV-1 유래 당단백질 D 유전자를 포함하는 셔틀 벡터를 제작하기 위해 상기 pBSKII SK(-)-gD-5' 플라스미드를 HindIII와 XbaI으로 절단하여 648bp의 당단백질 D의 5’영역 부위(gD-5')를 얻었다. 획득한 유전자를 HindIII와 XbaI으로 절단한 pSP72 플라스미드 벡터에 삽입하여 pSP72-gD-5' 플라스미드를 제작하였다.

도 4는 pSP72-gD-5' 플라스미드의 모식도이다.

pSP72-gD-5' 플라스미드의 클로닝 여부를 검증하기 위해서, gD-5'유전자가 삽입되었는지를 확인하기 위하여 상기 pSP72-gD-5' 플라스미드를 제한효소 PvuII로 절단한 후 전기영동을 수행하였다.

도 5는 pSP72-gD-5' 플라스미드의 클로닝 여부를 검증하기 위한 전기영동을 수행한 결과이다.

도 5에 나타낸 바와 같이, 대조군인 pSP72 자체는 제한효소 처리에 의해 2400bp의 단일 밴드를 보인 반면, 당단백질 유전자가 삽입된 3개의 플라스미드에서는 200bp의 특이적 밴드를 보였으므로, pSP72-gD-5' 플라스미드가 성공적으로 클로닝 되었음을 확인하였다.

최종적으로, 재조합 HSV-1을 제조하기 위한 재조합 벡터를 제조하기 위하여, 암 표적 유전자로 EGFRvIII에 대한 scFv 서열을 삽입해보았다. 당업계에 공지된 splicing by overlapping extension(SOEing) PCR 기법을 통해 수행하였으며 biotechnology letter (2005) 27; 289-295 의 논문을 참고하여 수행하였다. 구체적으로, EGFRvIII의 HV와 HL 유전자가 삽입된 플라스미드 벡터를 주형으로 하기 표 1과 같은 NcoI-gD-6B5 링커 센스 프라이머와 NcoI-gD-6B5 링커 안티센스 프라이머를 이용하여 EGVRvIII scFv 유전자를 증폭하는 PCR을 수행하였다(PCR1). 또한, pSP72-gD-5’을 주형으로 링커-gD-BssHII 센스 프라이머와 링커-gD-BssHII 안티센스 프라이머를 이용하여 당단백질 D 유전자를 증폭하는 PCR을 수행하였다(PCR2).

도 6은 EGVRvIII scFv 유전자와 NcoI-gD-6B5 linker 센스 프라이머 및 NcoI-gD-6B5 linker 안티센스 프라이머의 위치를 나타낸 모식도이다.

도 7은 당단백질 D 유전자와 Linker-gD-BssHII 센스 프라이머 및 Linker-gD-BssHII 안티센스 프라이머의 위치를 나타낸 모식도이다.

프라이머 명칭	서열번호	서열
NcoI-gD-6B5 linker 센스	3	5’- catgccatggggtccgcggc caggttactctgaaagagtctggccctgggata-3’ (볼드체: NcoI 제한효소 서열)
NcoI-gD-6B5 linker 안티센스	4	5’- ccaccgcttccccctcccccgctgccaccgccaccttttatttccagcttggtcccccctcCgaacgtgtacggaacatgT-3’ (볼드체: 링커 서열)
Linker-gD-BssHII 센스	5	5’- CAGCGGGGGAGGGGGAAGCGGTGGCGGAGGGAGTGCAAGTCACATCCAGGCGGGCCTACCGGA -3’ (볼드체: 링커 서열)
Linker-gD-BssHII 안티센스	6	5’- TTGGCGCGCTCCAACACGGCGTAGTAAACCGTGATCGGG- 3’ (볼드체: BssHII 제한효소 서열)

상기 두 PCR에서 얻은 PCR 산물 PCR1 및 PCR2를 1:1로 섞은 후 이를 주형으로 NcoI-gD-6B5 링커 센스 프라이머와 링커-gD-BssHII 안티센스 프라이머로 다시 PCR을 수행하여 EGFRvIII scFv와 당단백질 D가 링커로 연결된 PCR 산물을 얻었다(PCR3). 상기 산물이 잘 증폭되었는지 확인하기 위해서 전기영동을 수행하였다.

도 8은 EGFRvIII scFv와 당단백질 D가 링커로 연결되었는지 확인하기 위해 PCR 산물을 전기영동한 사진이다.

도 8에 나타낸 바와 같이, EGVRvIII scFv 유전자 증폭 산물인 PCR1은 775bp이고, 당단백질 D 유전자 증폭 산물인 PCR2는 120bp이며, 이들이 연결된 유전자 증폭 산물인 PCR3(gD-5'-scFv)은 890bp임을 확인하였으므로, PCR에 의해 잘 연결되었음을 확인하였다.

상기 PCR 산물을 NcoI과 BssHII 제한 효소로 절단한 후 pSP72-gD-5’에 동일한 제한효소를 이용해 gD-5'-scFv 서열을 클로닝하여 gD 서열 일부가 암 표적 서열인 EGFRvIII scFv로 치환된 pSP72-gD-scFv를 제작하였다.

도 9는 pSP72-gD-5'-scFv의 모식도이다.

pSP72-gD-5'-scFv가 제대로 클로닝 되었는지 여부를 확인하기 위해서 상기 벡터에 BglII의 제한효소를 처리하고 전기영동하였다.

도 10은 pSP72-gD-5'-scFv 클로닝 여부를 검증하기 위한 전기영동 결과이다.

도 10에 나타낸 바와 같이, pSP72-gD-5'-scFv에서 특이적으로 발생하는 750bp와 3020bp 크기의 밴드를 확인하였으며 DNA 시퀀싱 결과를 just bio에서 제공하는 alignment tool을 이용하여 최종 확인 하였다. 확인 결과, pSP72-gD-5'-scFv가 성공적으로 클로닝 되었음을 확인하였다.

SEQUENCE LISTING <110> SUNGKWANG MEDICAL FOUNDATION <120> A vector for preparing recombinant herpes simplex virus <130> PN122409 <160> 6 <170> PatentIn version 3.2 <210> 1 <211> 152011 <212> DNA <213> HSV-1 <400> 1 gcagcccggg ccccccgcgg gcgcgcgcgc gcgcaaaaaa ggcgggcggc ggtccgggcg 60 gcgtgcgcgc gcgcggcggg cgtggggggc ggggccgcgg gagcggggga ggagcggggg 120 aggagcgggg ggaggagcgg ggggaggagc ggggggagga gcggggggag gagcgggggg 180 aggagcgggg ggaggagcgg ggggaggagc ggggggagga gcggggggag gagcgggggg 240 aggagcgggg ggaggagcgg ggggaggagc ggggggagga gcggggggag gagcgggggg 300 aggagcgggg gaggagcggc cagaccccgg aaacgggccc cccccaaaac acaccccccg 360 ggggtcgcgc gcggcccttt aaaggcgggc ggcgggcagc ccgggccccc cgcggccgag 420 actagcgagt tagacaggca agcactactc gcctctgcac gcacatgctt gcctgtcaaa 480 ctctaccacc ccggcacgct ctctgtctcc atggcccgcc gccgccatcg cggcccccgc 540 cgcccccggc cgcccgggcc cacgggcgcg gtcccaaccg cacagtccca ggtaacctcc 600 acgcccaact cggaacccgt ggtcaggagc gcgcccgcgg ccgccccgcc gccgcccccc 660 gccagtgggc ccccgccttc ttgttcgctg ctgctgcgcc agtggctcca cgttcccgag 720 tccgcgtccg acgacgacga cgacgactgg ccggacagcc ccccgcccga gccggcgcca 780 gaggcccggc ccaccgccgc cgccccccgc ccccggtccc caccgcccgg cgcgggcccg 840 gggggcgggg ctaacccctc ccaccccccc tcacgcccct tccgccttcc gccgcgcctc 900 gccctccgcc tgcgcgtcac cgcagagcac ctggcgcgcc tgcgcctgcg acgcgcgggc 960 ggggaggggg cgccgaagcc ccccgcgacc cccgcgaccc ccgcgacccc cacgcgggtg 1020 cgcttctcgc cccacgtccg ggtgcgccac ctggtggtct gggcctcggc cgcccgcctg 1080 gcgcgccgcg gctcgtgggc ccgcgagcgg gccgaccggg ctcggttccg gcgccgggtg 1140 gcggaggccg aggcggtcat cgggccgtgc ctggggcccg aggcccgtgc ccgggccctg 1200 gcccgcggag ccggcccggc gaactcggtc taacgttaca cccgaggcgg cctgggtctt 1260 ccgcggagct cccgggagct ccgcaccaag ccgctctccg gagagacgat ggcaggagcc 1320 gcgcatatat acgcttggag ccggcccgcc cccgaggcgg gcccgccctc ggagggcggg 1380 actggccaat cggcggccgc cagcgcggcg gggcccggcc aaccagcgtc cgccgagtcg 1440 tcggggcccg gcccactggg cggtaactcc cgcccagtgg gccgggccgc ccacttcccg 1500 gtatggtaat taaaaacttg cagaggcctt gttccgcttc ccggtatggt aattagaaac 1560 tcattaatgg gcggccccgg ccgcccttcc cgcttccggc aattcccgcg gcccttaatg 1620 ggcaaccccg gtattccccg cctcccgcgc cgcgcgtaac cactcccctg gggttccggg 1680 ttatgttaat tgcttttttg gcggaacaca cggcccctcg cgcattggcc cgcgggtcgc 1740 tcaatgaacc cgcattggtc ccctggggtt ccgggtatgg taatgagttt cttcgggaag 1800 gcgggaagcc ccggggcacc gacgcaggcc aagcccctgt tgcgtcggcg ggaggggcat 1860 gctaatgggg ttctttgggg gacaccgggt tggtccccca aatcgggggc cgggccgtgc 1920 atgctaatga tattctttgg gggcgccggg ttggtccccg gggacggggc cgccccgcgg 1980 tgggcctgcc tcccctggga cgcgcggcca ttgggggaat cgtcactgcc gcccctttgg 2040 ggaggggaaa ggcgtggggt ataagttagc cctggcccga cggtctggtc gcatttgcac 2100 ctcggcactc ggagcgagac gcagcagcca ggcagactcg ggccgccccc tctccgcatc 2160 accacagaag ccccgcctac gttgcgaccc ccagggaccc tccgtcagcg accctccagc 2220 cgcatacgac ccccatggag ccccgccccg gagcgagtac ccgccggcct gagggccgcc 2280 cccagcgcga ggtgaggggc cgggcgccat gtctggggcg ccatgttggg gggcgccatg 2340 ttggggggcg ccatgttggg ggacccccga cccttacact ggaaccggcc gccatgttgg 2400 gggaccccca ctcatacacg ggagccgggc gccatgttgg ggcgccatgt tagggggcgt 2460 ggaaccccgt gacactatat atacagggac cgggggcgcc atgttagggg gcgcggaacc 2520 ccctgaccct atatatacag ggaccggggt cgccctgtta ggggtcgcca tgtgaccccc 2580 tgactttata tatacagacc cccaacacct acacatggcc cctttgactc agacgcaggg 2640 cccggggtcg ccgtgggacc cccctgactc atacacagag acacgccccc acaacaaaca 2700 cacagggacc ggggtcgccg tgttaggggg cgtggtcccc actgactcat acgcagggcc 2760 cccttactca cacgcatcta ggggggtggg gaggagccgc ccgccatatt tgggggacgc 2820 cgtgggaccc ccgactccgg tgcgtctgga gggcgggaga agagggaaga agaggggtcg 2880 ggatccaaag gacggaccca gaccaccttt ggttgcagac ccctttctcc cccctcttcc 2940 gaggccagca ggggggcagg actttgtgag gcgggggggg agggggaact cgtgggcgct 3000 gattgacgcg ggaaatcccc ccattcttac ccgccccccc ttttttcccc tcagcccgcc 3060 ccggatgtct gggtgtttcc ctgcgaccga gacctgccgg acagcagcga ctcggaggcg 3120 gagaccgaag tgggggggcg gggggacgcc gaccaccatg acgacgactc cgcctccgag 3180 gcggacagca cggacacgga actgttcgag acggggctgc tggggccgca gggcgtggat 3240 gggggggcgg tctcgggggg gagccccccc cgcgaggaag accccggcag ttgcgggggc 3300 gccccccctc gagaggacgg ggggagcgac gagggcgacg tgtgcgccgt gtgcacggat 3360 gagatcgcgc cccacctgcg ctgcgacacc ttcccgtgca tgcaccgctt ctgcatcccg 3420 tgcatgaaaa cctggatgca attgcgcaac acctgcccgc tgtgcaacgc caagctggtg 3480 tacctgatag tgggcgtgac gcccagcggg tcgttcagca ccatcccgat cgtgaacgac 3540 ccccagaccc gcatggaggc cgaggaggcc gtcagggcgg gcacggccgt ggactttatc 3600 tggacgggca atcagcggtt cgccccgcgg tacctgaccc tgggggggca cacggtgagg 3660 gccctgtcgc ccacccaccc tgagcccacc acggacgagg atgacgacga cctggacgac 3720 ggtgaggcgg gggggcggcg aggaccctgg gggaggagga ggaggggggg gggagggagg 3780 aataggcggg cgggcgggcg aggaaagggc gggccgggga gggggcgtaa cctgatcgcg 3840 ccccccgttg tctcttgcag cagactacgt accgcccgcc ccccgccgga cgccccgcgc 3900 ccccccacgc agaggcgccg ccgcgccccc cgtgacgggc ggggcgtctc acgcagcccc 3960 ccagccggcc gcggctcgga cagcgccccc ctcggcgccc atcgggccac acggcagcag 4020 taacactaac accaccacca acagcagcgg cggcggcggc tcccgccagt cgcgagccgc 4080 ggtgccgcgg ggggcgtctg gcccctccgg gggggttggg gttgttgaag cggaggcggg 4140 gcggccgagg ggccggacgg gcccccttgt caacagaccc gccccccttg caaacaacag 4200 agaccccata gtgatcagcg actccccccc ggcctctccc cacaggcccc ccgcggcgcc 4260 catgccaggc tccgcccccc gccccggtcc ccccgcgtcc gcggccgcgt cgggccccgc 4320 gcgcccccgc gcggccgtgg ccccgtgtgt gcgggcgccg cctccggggc ccggcccccg 4380 cgccccggcc cccggggcgg agccggccgc ccgccccgcg gacgcgcgcc gtgtgcccca 4440 gtcgcactcg tccctggctc aggccgcgaa ccaagaacag agtctgtgcc gggcgcgtgc 4500 gacggtggcg cgcggctcgg gggggccggg cgtggagggt ggacacgggc cctcccgcgg 4560 cgccgccccc tccggcgccg ccccctccgg cgcccccccg ctcccctccg ccgcctctgt 4620 cgagcaggag gcggcggtgc gtccgaggaa gaggcgcggg tcgggccagg aaaacccctc 4680 cccccagtcc acgcgtcccc ccctcgcgcc ggcaggggcc aagagggcgg cgacgcaccc 4740 cccctccgac tcagggccgg gggggcgcgg ccagggaggg cccgggaccc ccctgacgtc 4800 ctcggcggcc tccgcctctt cctcctccgc ctcttcctcc tcggccccga ctcccgcggg 4860 ggccacctct tccgccaccg gggccgcgtc ctcctccgct tccgcctcct cgggcggggc 4920 cgtcggtgcc ctgggaggga gacaagagga aacctccctc ggcccccgcg ctgcttctgg 4980 gccgcggggg ccgaggaagt gtgcccggaa gacgcgccac gcggagactt ccggggccgt 5040 ccccgcgggc ggcctcacgc gctacctgcc catctcgggg gtctctagcg tggtcgccct 5100 gtcgccttac gtgaacaaga cgatcacggg ggactgcctg cccatcctgg acatggagac 5160 ggggaacatc ggggcgtacg tggtcctggt ggaccagacg ggaaacatgg cgacccggct 5220 gcgggccgcg gtccccggct ggagccgccg caccctgctc cccgagaccg cgggtaacca 5280 cgtgacgccc cccgagtacc cgacggcccc cgcgtcggag tggaacagcc tctggatgac 5340 ccccgtgggg aacatgctgt tcgaccaggg caccctagtg ggcgccctgg acttccgcag 5400 cctgcggtct cggcacccgt ggtccgggga gcagggggcg tcgacccggg acgagggaaa 5460 acaataaggg acgcccccgt gtttgtgggg aggggggggt cgggcgctgg gtggtctctg 5520 gccgcgccca ctacaccagc caatccgtgt cggggaggtg gaaagtgaaa gacacgggca 5580 ccacacacca gcgggtcttt tgtgttggcc ctaataaaaa aaactcaggg gatttttgct 5640 gtctgttggg aaataaaggt ttacttttgt atcttttccc tgtctgtgtt ggatgtatcg 5700 cgggggtgcg tgggagtggg ggtgcgtggg agtgggggtg cgtgggagtg ggggtgcgtg 5760 ggagtggggg tgcgtgggag tgggggtgcg tgggagtggg ggtgcgtggg agtgggggtg 5820 cgtgggagtg ggggtgcgtg ggagtggggg tgccatgttg ggcaggctct ggtgttaacc 5880 acagagccgc ggcccgggct gcctgaccac cgatccccga aagcatcctg ccactggcat 5940 ggagccagaa ccacagtggg ttgggtgtgg gtgttaagtt tccgcgagcg cctgcccgcc 6000 cggactgacc tggcctctgg ccgccacaaa gggcgggggg gggggttaac tacactatag 6060 ggcaacaaag gatgggaggg gtagcggggc gggacggggc gcccaaaagg gggtcggcca 6120 caccacagac gtgggtgttg gggggtgggg cggaggggtg gggggggaga cagaaacagg 6180 aacatagtta gaaaacaaga atgcggtgca gccagagaat cacaggagac gaggggatgg 6240 gcgtgttggt taccaaccca cacccaggca tgctcggtgg tatgaaggag ggggggcggt 6300 gtttcttaga gaccgccggg ggacgtgggg ttggtgtgca aaggcacgcg cacccgcgcc 6360 ggccaggtgg gccggtaccc catccccccc tcccccgacc cttcccaccc ccgcgtgcca 6420 gagatcaccc cggtcccccg gcacccgcca ctcctccata tcctcgcttt aggaacaact 6480 ttaggggggg gtacacacgc gccgtgcatt tccttccaca ccccccccct cccccgcact 6540 cccccccccc aggcagtaag acccaagcat agagagccag gcacaaaaac acaggcgggg 6600 tgggacacat gccttcttgg agtacgtggg tcattggcgt ggggggttac agcgacaccg 6660 gccgaccccc tggcggtctt ccagccggcc cttagataag ggggcagttg gtggtcggac 6720 gggtaagtaa cagagtctaa ctaagggtgg gaggggggga aaataacggg ctggtgtgct 6780 gtaacacgag cccacccgcg agtggcgtgg ccgaccttag cctctggggc gccccctgtc 6840 gtttgggtcc ccccccctct attggggaga agcaggtgtc taacctacct ggaaacgcgg 6900 cgtctttgtt gaacgacacc ggggcgccct cgacgagtgg gataacgggg gaggaaggga 6960 gggaggaggg tactgggggt gaaggggggg ggggagaagc gagaacagga aaggcgacgg 7020 agcccggcag aacaccgagg aaaaaaaaac cacagcgcat gcgccgggcc gttgtggggc 7080 cccgggccgg ggccccttgg gtccgccggg gccccgggcc gggccgccac gggggccggc 7140 cgttggcggt aaccccgagt gttcatctca ggccccgggc cgggaacccg gaaaagcctc 7200 cggggggcct ttttcgcgtc gcgtgccggc gagcgggtcc ggacggggcc cggaccgccg 7260 cggtcggggg cccctcgtcc cgggccgtac gcggccttcg ccccgtgagg ggacagacga 7320 acgaaacatt ccggcgacgg aacgaaaaac accccagacg ggttaaagaa acagaaaccg 7380 caacccccac cacccccgaa acggggaaaa cgaaaaaaca gaccagcggc cggccggcgc 7440 ttagggggag gatgtcgccg acgccccttg gccgccccgg ctgcaggggg gcccggagag 7500 ccgcggcacc cggacgcgcc cggaaagtct ttcgcaccac cggcgatcgg cacggccgcg 7560 cccccgcttt tataaaggct cagatgacgc agcaaaaaca ggccacagca ccacatgggt 7620 aggtgatgta attttatttt cctcgtctgc ggcctaatgg atttccgggc gcggtgcccc 7680 tgtctgcaga gcacttaacg gattgatatc tcgcgggcac gcgcgccctt aatggaccgg 7740 cgcggggcgg ggggccggat acccacacgg gcgggggggg gtgtcgcggg ccgtctgctg 7800 gcccgcggcc acataaacaa tgactcgggg cctttctgcc tctgccgctt gtgtgtgcgc 7860 gcgccggctc tgcggtgtcg gcggcggcgg cggcggtggc cgccgtgttc ggtctcggta 7920 gccggccggc gggtggactc gcggggggcc ggagggtgga aggcaggggg gtgtaggatg 7980 ggtatcagga cttccacttc ccgtccttcc atcccccgtt cccctcggtt gttcctcgcc 8040 tcccccaaca ccccgccgct ttccgttggg gttgttattg ttgtcgggat cgtgcgggcc 8100 gggggtcgcc ggggcagggg cgggggcgtg ggcgggggtg ctcgtcgatc gaccgggctc 8160 agtgggggcg tggggtgggt gggagaaggc gaggagactg gggtgggggt gtcggtgggt 8220 ggttgttttt tgtggttgtt ttttgtgtct gtttccgtcc cccgtcaccc ccctccctcc 8280 gtcccctccg tccccccgtc gcgggtgttt gtgtttgttt attccgacat cggtttattt 8340 aaaataaaca cagccgttct gcgtgtctgt tcttgcgtgt ggctgggggc ttatatgtgg 8400 ggtcccgggg gcgggatggg gtttagcggc ggggggcggc gcgccggacg gggcgctgga 8460 gataacggcc cccggggaac gggggaccgg ggctgggtat cccgaggtgg gtgggtgggc 8520 ggcggtggcc gggccgggcc gggccgggcc gggtgggcgg ggtttggaaa aacgaggagg 8580 aggaggagaa ggcggggggg gagacggggg gaaagcaagg acacggcccg gggggtggga 8640 gcgcgggccg ggccgctcgt aagagccgcg acccggccgc cggggagcgt tgtcgccgtc 8700 ggtctgccgg cccccgtccc tccctttttt gaccaaccag cgccctcccc cccaccacca 8760 ttcctactac caccaccacc accaccccca ccaccgacac ctcccgcgca cccccgccca 8820 catcccccca ccccgcacca cgagcacggg gtgggggtag caggggatca aaggggggca 8880 aagccggcgg ggcggttcgg gggggcggga gaccgagtag gcccgcccat acgcggcccc 8940 tcccggcagc cacgcccccc agcgtcgggt gtcacgggga aagagcaggg gagagggggg 9000 gagaggggag agggggggag aggggagagg gggggagagg ggagaggggg ggagagggga 9060 gaggggggga gaggggagag ggggggagag gggagagggg gggagagggg agaggggggg 9120 agaggggaga gggggggaga ggggagaggg ggggagaggg ggtatataaa ccaacgaaaa 9180 gcgcgggaac ggggatacgg ggcttgtgtg gcacgacgtc gtggttgtgt tactgggcaa 9240 acacttgggg actgtaggtt tctgtgggtg ccgaccctag gcgctatggg gattttgggt 9300 tgggtcgggc ttattgccgt tggggttttg tgtgtgcggg ggggcttgtc ttcaaccgaa 9360 tatgttattc ggagtcgggt ggctcgagag gtgggggata tattaaaggt gccttgtgtg 9420 ccgctcccgt ctgacgatct tgattggcgt tacgagaccc cctcggctat aaactatgct 9480 ttgatagacg gtatattttt gcgttatcac tgtcccggat tggacacggt cttgtgggat 9540 aggcatgccc agaaggcata ttgggttaac ccctttttat ttgtggcggg ttttctggag 9600 gacttgagtc accccgcgtt tcctgccaac acccaggaaa cagaaacgcg cttggccctt 9660 tataaagaga tacgccaggc gctggacagt cgcaagcagg ccgccagcca cacacctgtg 9720 aaggctgggt gtgtgaactt tgactattcg cgcacccgcc gctgtgtagg gcgacaggat 9780 ttgggaccta ccaacggaac gtctggacgg accccggttc tgccgccgga cgatgaagcg 9840 ggcctgcaac cgaagcccct caccacgccg ccgcccatca tcgccacgtc ggaccccacc 9900 ccgcgacggg acgccgccac aaaaagcaga cgccgacgac cccactcccg gcgcctctaa 9960 cgatgcctcg acggaaaccc gtccgggttc ggggggcgaa ccggccgcct gtcgctcgtc 10020 agggccggcg ggcgctcctc gccgccctag aggctgtccc gctggtgtga cgttttcctc 10080 gtccgcgccc cccgaccctc ccatggattt aacaaacggg ggggtgtcgc ctgcggcgac 10140 ctcggcgcct ctggactgga ccacgtttcg gcgtgtgttt ctgatcgacg acgcgtggcg 10200 gcccctgatg gagcctgagc tggcgaaccc cttaaccgcc cacctcctgg ccgaatataa 10260 tcgtcggtgc cagaccgaag aggtgctgcc gccgcgggag gatgtgtttt cgtggactcg 10320 ttattgcacc cccgacgagg tgcgcgtggt tatcatcggc caggacccat atcaccaccc 10380 cggccaggcg cacggacttg cgtttagcgt gcgcgcgaac gtgccgcctc ccccgagtct 10440 tcggaatgtc ttggtggccg tcaagaactg ttatcccgag gcacggatga gcggccacgg 10500 ttgcctggaa aagtgggcgc gggacggcgt cctgttacta aacacgaccc tgaccgtcaa 10560 gcgcggggcg gcggcgtccc actctagaat cggttgggac cgcttcgtgg gcggagttat 10620 ccgccggttg gccgcgcgcc gccccggcct ggtgtttatg ctctggggcg cacacgccca 10680 gaatgccatc aggccggacc ctcgggtcca ttgcgtcctc aagttttcgc acccgtcgcc 10740 cctctccaag gttccgttcg gaacctgcca gcatttcctc gtggcgaacc gatacctcga 10800 gacccggtcg atttcaccca tcgactggtc ggtttgaaag gcatcgacgt ccggggtttt 10860 tgtcggtggg ggcttttggg tatttccgat gaataaagac ggttaatggt taaacctctg 10920 gtctcatacg ggtcggtgat gtcgggcgtc gggggagagg gagttccctc tgcgcttgcg 10980 attctagcct cgtggggctg gacgttcgac acgccaaacc acgagtcggg gatatcgcca 11040 gatacgactc ccgcagattc cattcggggg gccgctgtgg cctcacctaa ccaaccttta 11100 cacgggggcc cggaacggga ggccacagcg ccgtctttct ccccaacgcg cgcggatgac 11160 ggcccgccct gtaccgacgg gccctacgtg acgtttgata ccctgtttat ggtgtcgtcg 11220 atcgacgaat tagggcgtcg ccagctcacg gacaccatcc gcaaggacct gcggttgtcg 11280 ctggccaagt ttagcattgc gtgcaccaag acctcctcgt tttcgggaaa cgccccgcgc 11340 caccacagac gcggggcgtt ccagcgcggc acgcgggcgc cgcgcagcaa caaaagcctc 11400 cagatgtttg tgttgtgcaa acgcgcccac gccgctcgag tgcgagagca gcttcgggtc 11460 gttattcagt cccgcaagcc gcgcaagtat tacacgcgat cttcggacgg gcggctctgc 11520 cccgccgtcc ccgtgttcgt ccacgagttc gtctcgtccg agccaatgcg cctccaccga 11580 gataacgtca tgctggcctc gggggccgag taaccgcccc ccccccatgc caccctcact 11640 gcccgtcgcg cgtgtttgat gttaataaat aacacataaa tttggctggt tgtttgttgt 11700 ctttaatgga ccgcccgcaa gggggggggg gcgtttcagt gtcgggtgac gagcgcgatc 11760 cggccgggat cctaggaccc caaaagtttg tctgcgtatt ccagggtggg gctcagttga 11820 atctcccgca gcacctctac cagcaggtcc gcggtgggct ggagaaactc ggccgtcccg 11880 gggcaggcgg ttgtcggggg tggaggcgcg gcgcccaccc cgtgtgccgc gcctggcgtc 11940 tcctctgggg gcgacccgta aatggttgca gtgatgtaaa tggtgtccgc ggtccagacc 12000 acggtcaaaa tgccggccgt ggcgctccgg gcgctttcgc cgcgcgagga gctgacccag 12060 gagtcgaacg gatacgcgta catatgggcg tcccacccgc gttcgagctt ctggttgctg 12120 tcccggccta taaagcggta ggcacaaaat tcggcgcgac agtcgataat caccaacagc 12180 ccaatggggg tgtgctggat aacaacgcct ccgcgcggca ggcggtcctg gcgctcccgg 12240 ccccgtacca tgatcgcgcg ggtgccgtac tcaaaaacat gcaccacctg cgcggcgtcg 12300 ggcagtgcgc tggtcagcga ggccctggcg tggcataggc tatacgcgat ggtcgtctgt 12360 ggattggaca tctcgcggtg ggtagtgagt cccccgggcc gggttcggtg gaactgtaag 12420 gggacggcgg gttaatagac aatgaccacg ttcggatcgc gcagagccga tagtatgtgc 12480 tcactaatga cgtcatcgcg ctcgtggcgc tcccggagcg gatttaagtt catgcgaagg 12540 aattcggagg aggtggtgcg ggacatggcc acgtacgcgc tgttgaggcg caggttgccg 12600 ggcgtaaagc agatggcgac cttgtccagg ctaaggccct gggagcgcgt gatggtcatg 12660 gcaagcttgg agctgatgcc gtagtcggcg tttatggcca tggccagctc cgtagagtca 12720 atggactcga caaactcgct gatgttggtg ttgacgacgg acatgaagcc gtgttggtcc 12780 cgcaagacca cgtaaggcag gggggcctct tccagtaact cggccacgtt ggccgtcgcg 12840 tgccgcctcc gcagctcgtc cgcaaaggca aacacccgtg tgtacgtgta tcccatgagc 12900 gtataattgt ccgtctgcag ggcgacggac atcagccccc cgcgcggcga gccggtcagc 12960 atctcgcagc cccggaagat aacgttgtcc acgtacgtgc taaagggggc gacttcaaat 13020 gcctccccga agagctcttg gaggattcgg aatctcccga ggaaggcccg cttcagcagc 13080 gcaaactggg tgtgaacggc ggcggtggtc tccggttccc cgggggtgta gtggcagtaa 13140 aacacgtcga gctgttgttc gtccagcccc gcgaaaataa cgtcgaggtc gtcgtcggga 13200 aaatcgtccg ggcccccgtc ccgcggcccc agttgcttaa aatcaaacgc acgctcgccg 13260 ggggcgcctg cgtcggccat taccgacgcc tgcgtcggca cccccgaaga tttggggcgc 13320 agagacagaa tctccgccgt tagttctccc atgcgggcgt acgcgagggt cctctgggtc 13380 gcatccaggc ccgggcgctg cagaaagttg taaaaggaga taagcccgct aaatatgagc 13440 cgcgacagga acctgtaggc aaactccacc gaagtctccc cctgagtctt tacaaagctg 13500 tcgtcacgca acactgcctc gaaggcccgg aacgtcccac taaacccaaa aaccagtttt 13560 cgcaggcgcg cggtcaccgc gatctggctg ttgaggacgt aagtgacgtc gttgcgggcc 13620 acgaccagct gctgtttgct gtgcacctcg cagcgcatgt gccccgcgtc ctggtcctgg 13680 ctctgcgagt agttggtgat gcggctggcg ttggccgtga gccacttttc aatagtcagg 13740 ccgggctggt gtgtcagccg tcggtattcg tcaaactcct tgaccgacac gaacgtaagc 13800 acggggaggg tgaacacgac gaactccccc tcacgggtca ccttcaggta ggcgtggagc 13860 ttggccatgt acgcgctcac ctctttgtgg gaggagaaca gccgcgtcca gccggggagg 13920 ttggcggggt tggtgatgta gttttccggg acgacgaagc gatccacgaa ctgcatgtgc 13980 tcctcggtga tgggcaggcc gtactccagc accttcatga ggttaccgaa ctcgtgctcg 14040 acgcaccgtt tgttgttaat aaaaatggcc cagctatacg agaggcgggc gtactcgcgc 14100 agcgtgcggt tgcagatgag gtacgtgagc acgttctcgc tctggcggac ggaacaccgc 14160 agtttctggt gctcgaaggt cgactccagg gacgccgtct gcgtcggcga gcccacacac 14220 accaacacgg gccgcaggcg ggccgcgtac tggggggtgt ggtacagggc gttaatcatc 14280 caccagcaat acaccacggc cgtgaggagg tgacgcccaa ggagcccggc ctcgtcgatg 14340 acgatcacgt tgctgcgggt aaaggccggc agcgccccgt gggtggccgg ggccaaccgc 14400 gtcagggcgc cctcggccaa ccccagggtc cgttccaggg cggccagggc gcgaaactcg 14460 ttccgcaact cctcgccccc ggaggcggcc agggcgcgct tcgtgaggtc caaaatcacc 14520 tcccagtagt acgtcagatc tcgtcgctgc aggtcctcca gcgaggcggg gttgctggtc 14580 agggtgtacg ggtactgtcc cagttgggcc tggacgtgat tcccgcgaaa cccaaattca 14640 tgaaagatgg tgttgatggg tcggctgaga aaggcgcccg agagtttggc gtacatgttt 14700 tgggccgcaa tgcgcgtggc gcccgtcacc acacagtcca agacctcgtt gattgtctgc 14760 acgcacgtgc tctttccgga gccagcgttg ccggtgataa gatacaccgc gaacggaaac 14820 tccctgaggg gcaggcctgc gggggactct aaggccgcca cgtcccggaa ccactgcaga 14880 cggggcactt gcgctccgtc gagctgttgt tgcgagagct ctcggatgcg cttaaggatt 14940 ggctgcaccc cgtgcataga cgtaaaattt aaaaaggcct cggccctccc tggaacggct 15000 ggtcggtccc cgggttgctg aaggtgcggc gggccgggtt tctgtccgtc tagctggcgc 15060 tccccgccgg ccgccgccat gaccgcacca cgctcgtggg cccccactac gcgtgcgcgg 15120 ggggacacgg aagcgctgtg ctcccccgag gacggctggg taaaggttca ccccaccccc 15180 ggtacgatgc tgttccgtga gattctccac gggcagctgg ggtataccga gggccagggg 15240 gtgtacaacg tcgtccggtc cagcgaggcg accacccggc agctgcaggc ggcgatcttt 15300 cacgcgctcc tcaacgccac cacttaccgg gacctcgagg cggactggct cggccacgtg 15360 gcggcccgcg gtctgcagcc ccaacggctg gttcgccggt acaggaacgc ccgggaggcg 15420 gatatcgccg gggtggccga gcgggtgttc gacacgtggc ggaacacgct taggacgacg 15480 ctgctggact ttgcccacgg gttggtcgcc tgctttgcgc cgggcggccc gagcggcccg 15540 tcaagcttcc ccaaatatat cgactggctg acgtgcctgg ggctggtccc catattacgc 15600 aagcgacaag aagggggtgt gacgcagggt ctgagggcgt ttctcaagca gcacccgctg 15660 acccgccagc tggccacggt cgcggaggcc gcggagcgcg ccggccccgg gttttttgag 15720 ctggcgctgg ccttcgactc cacgcgcgtg gcggactacg accgcgtgta tatctactac 15780 aaccaccgcc ggggcgactg gctcgtgcga gaccccatca gcgggcagcg cggagaatgt 15840 ctggtgctgt ggcccccctt gtggaccggg gaccgtctgg tcttcgattc gcccgtccag 15900 cggctgtttc ccgagatcgt cgcgtgtcac tccctccggg aacacgcgca cgtctgccgg 15960 ctgcgcaata ccgcgtccgt caaggtgctg ctggggcgca agagcgacag cgagcgcggg 16020 gtggccggtg ccgcgcgggt cgttaacaag gtgttggggg aggacgacga gaccaaggcc 16080 gggtcggccg cctcgcgcct cgtgcggctt atcatcaaca tgaagggcat gcgccacgta 16140 ggcgacatta acgacaccgt gcgtgcctac ctcgacgagg ccggggggca cctgatagac 16200 gccccggccg tcgacggtac cctccctgga ttcggcaagg gcggaaacag ccgcgggtct 16260 gcgggccagg accagggggg gcgggcgccg cagcttcgcc aggccttccg cacggccgtg 16320 gttaacaaca tcaacggcgt gttggagggc tatataaata acctgtttgg aaccatcgag 16380 cgcctgcgcg agaccaacgc gggcctggcg acccaattgc aggagcgcga ccgcgagctc 16440 cggcgcgcaa cagcgggggc cctggagcgc cagcagcgcg cggccgacct ggcggccgag 16500 tccgtgaccg gtggatgcgg cagccgccct gcgggggcgg acctgctccg ggccgactat 16560 gacattatcg acgtcagcaa gtccatggac gacgacacgt acgtcgccaa cagctttcag 16620 cacccgtaca tcccttcgta cgcccaggac ctggagcgcc tgtcgcgcct ctgggagcac 16680 gagctggtgc gctgttttaa aattctgtgt caccgcaaca accagggcca agagacgtcg 16740 atctcgtact ccagcggggc gatcgccgca ttcgtcgccc cctactttga gtcagtgctt 16800 cgggcccccc gggtaggcgc gcccatcacg ggctccgatg tcatcctggg ggaggaggag 16860 ttatgggatg cggtgtttaa gaaaacccgc ctgcaaacgt acctgacaga catcgcggcc 16920 ctgttcgtcg cggacgtcca gcacgcagcg ctgcccccgc ccccctcccc ggtcggcgcc 16980 gatttccggc ccggcgcgtc cccgcggggc cggtccagat cgcggtcgcc cggaagaact 17040 gcgccaggcg cgccggacca gggcgggggc atcgggcacc gggatggccg ccgcgacggc 17100 cgacgatgag gggtcggccg ccaccatcct caagcaggcc atcgccgggg accgcagcct 17160 ggtcgaggcg gccgaggcga ttagccagca gacgctgctc cgcctggcct gcgaggtgcg 17220 ccaggtcggc gaccgccagc cgcggtttac cgccaccagc atcgcgcgcg tcgacgtcgc 17280 gcctgggtgc cggttgcggt tcgttctgga cgggagtccc gaggacgcct atgtgacgtc 17340 ggaggattac tttaagcgct gctgcggcca gtccagttat cgcggcttcg cggtggcggt 17400 cctgacggcc aacgaggacc acgtgcacag cctggccgtg ccccccctcg ttctgctgca 17460 ccggttctcc ctgttcaacc ccagggacct cctggacttt gagcttgcct gtctgctgat 17520 gtacctggag aactgccccc gaagccacgc caccccgtcg acctttgcca aggttctggc 17580 gtggctcggg gtcgcgggtc gccgcacgtc cccattcgaa cgcgttcgct gccttttcct 17640 ccgcagttgc cactgggtcc taaacacact catgttcatg gtgcacgtaa aaccgttcga 17700 cgacgagttc gtcctgcccc actggtacat ggcccggtac ctgctggcca acaacccgcc 17760 ccccgttctc tcggccctgt tctgtgccac cccgacgagc tcctcattcc ggctgccggg 17820 gccgcccccc cgctccgact gcgtggccta taaccccgcc gggatcatgg ggagctgctg 17880 ggcgtcggag gaggtgcgcg cgcctctggt ctattggtgg ctttcggaga ccccaaaacg 17940 acagacgtcg tcgctgtttt atcagttttg ttgaatttta ggaaataaac ccggttttgt 18000 ttctgtggcc tcccgacgga tgcgcgtgtc cttcctccgt cttggtgggt gggtgtctgt 18060 gtatcgcgtc ccatctgtgc ggagaggggg ggcatgtcgg cacgtattcg gacagactca 18120 agcacacacg ggggagcgct cttgtctcag ggcaatgttt ttattggtca aactcaggca 18180 aacagaaacg acatcttgtc gtcaaaggga tacacaaact tccccccctc tccccatact 18240 cccgccagca ccccggtaaa caccaactca atctcgcgca ggatttcgcg caggtgatga 18300 gcgcagtcca cgggggggag cacaaggggc cgcgggtata gatcgacggg gacgccgacc 18360 gactccccgc ctccgggaca gacacgcacg acgcgccgcc agtagtgctc tgcgtccagc 18420 aaggcgccgc cgcggaaggc agtggggggc aaggggtcgc tagcctcaaa gggggacacc 18480 cgaacgctcc agtactccgc gtccaaccgt ttattaaacg cgtccacgat aaggcggtcg 18540 caggcgtcct ccataaggcc ccgggccgtg agtgcgtcct cctccggcac gcctgccgtt 18600 gtcaggccca ggacccgtcg cagcgtgtcg cgtacgaccc cggccgccgt ggtgtacgcg 18660 ggcccgcgga gaggaaatcc cccaagatgg tcagtgttgt cgcgggagtt ccagaaccac 18720 actcccgcct ggttccaggc gactgcgtgg gtgtagacgc cctcgagggc caggcacagt 18780 gggtgccgca gccggaggcc gttggcccta agcacggctc ccacggccgt ctcgatggcc 18840 cgccgggcgt cctcgatcac cccggaagcc gcatccgcgt cttgggggtc cacgttaaag 18900 acaccccaga acgcaccccc atcgcccccg cagaccgcga acttcaccga gctggccgtc 18960 tcctcgatct gcaggcagac ggcggccatt accccaccca ggagctgccg cagcgcaggg 19020 caggcgtcgc acgtgtccgg gaccaggcgc tccaagacgg ccccggccca gggctctgag 19080 ggagcggcca ccaccagcgc gtccagtctt gctaggcccg tccggccgtg ggggtccgcc 19140 agcccgctcc ccccgaggtc ggccagggcc gccaggagct gggcgcgaag tccggggaag 19200 caaaaccgcg ccgtccagac gggcccgacg gccgcgggcg ggtctaacag ttggatgatt 19260 ttagtggcgg gatgccaccg cgccaccgcc tcccgcaccg cgggcaggag gcatccggct 19320 gccgccgagg ccacgccggg ccaggctcgc ggggggagga cgaccctggc ccccaccgcg 19380 ggccaggccc ccaggagcgc ggcgtaagcg gccgcggccc cgcgcaccag gtcccgtgcc 19440 gactcggccg tggccggcac ggtgaacgtg ggccaacccg gaaaccccag gacggcaaag 19500 tacgggacgg gtcccccccg gacctcaaac tcgggcccca gaaaggcaaa gacgggggcc 19560 agggccccgg gggcggcgtg gaccgtggta tgccactgcc ggaaaagggc gacgagcgcc 19620 ggcgcggaga acttctcgcc ggcgcttaca aagtagtcgt aatcgcgggg cagcagcacc 19680 cgtgccgtga ctcgttgcgg gtgcccgcgt ggccgcaggc ccacctcgca cacctcgacc 19740 aggtccccga acgcgccctc cttcttgatc ggcggaaacg caagagtctg gtattcgcgc 19800 gcaaatagcg cggttccggt ggtgatgtta acggtcagcg aagcggcgga cgcgcactgg 19860 ggggtgtcgc gaatggccgc caggcgcgcc cacgccagcc gcgcgtcggg atgctcggca 19920 acgcgcgccg ccagggccat agggtcgatg tcaatgttgg cctccgcgac caggagagcg 19980 gcgcgagggg cggcgggcgg gccccacgac gctctctcaa ctttcaccac cagtcccgtg 20040 cgtgggtccg agccgatacg cagcggggcg aacagggcca ccggcccggt ctggcgctcc 20100 agggccgcca ggacgcacgc gtacagcgcc cgccacagag tcgggttctc caggggctcc 20160 agcggggagg cggccggcgt cgtcgcggcg cgggcggccg ccacgacggc ctggacggag 20220 acgtccgcgg agccgtagaa atcccgcagc tccgtcgcgg tgacggagac ctccgcaaag 20280 cgcgcgcgac cctcccctgc ggcgttgcga catacaaaat acaccagggc gtggaagtac 20340 tcgcgagcgc gggggggcag ccataccgcg taaagggtaa tggcgctgac gctctcctcc 20400 acccacacga tatctgcggt gtccatcgca cggcccctaa ggatcacggg cggtctgtgg 20460 gtcccatgct gccgtgcctg gccgggcccg gtgggtcgcg gaaaccggtg acgggggggg 20520 ggcggttttt ggggttgggg tgggggtggg aaacggcccg ggtccggggg ccaacttggc 20580 ccctcggtgc gttccggcaa cagcgccgcc ggtccgcgga cgaccacgta ccgaacgagt 20640 gcggtcccga gacttatagg gtgctaaagt tcaccgcccc ctgcatcatg ggccaggcct 20700 cggtggggag ctccgacagc gccgcctcca ggatgatgtc agcgttgggg ttggcgctgg 20760 atgagtgcgt gcgcaaacag cgcccccacg caggcacgcg tagcttgaag cgcgcgcccg 20820 caaactcccg cttgtgggcc ataagcaggg cgtacagctg cctgtgggtc cggcaggcgc 20880 tgtggtcgat gtggtgggcg tccaacaacc ccacgattgt ctgtttggtg aggtttttaa 20940 cgcgccccgc cccgggaaac gtctgcgtgc ttttggccat ctgcacgcca aacagttcgc 21000 cccagattat cttgaacagc gccaccgcgt ggtccgtctc gctaacggac ccgcgcgggg 21060 gacagccgct tagggcgtcg gcgacgcgct tgacggcttc ctccgagagc agaagtccgt 21120 cggttacgtt acagtggccc agttcgaaca ccagctgcat gtagcggtcg tagtgggggg 21180 tcagtaggtc cagcacgtca tcggggccga aggtcctccc agatcccccg gccgccgagt 21240 cccaatgcag gcgcgcggcc atggtgctgc acaggcacaa cagctcccag acgggggtta 21300 cgttcagggt ggggggcagg gccacgagct ccagctctcc ggtgacgttg atcgtgggga 21360 tgacgcccgt ggcgtagtgg tcatagatcc gccgaaatat ggcgctgctg cgggtggcca 21420 tgggaacgcg gagacaggcc tccagcaacg ccaggtaaat aaaccgcgtg cgtcccatca 21480 ggctgttgag gttgcgcatg agcgcgacaa tttccgccgg cgcgacatcg gaccggaggt 21540 atttttcgac gaaaagaccc acctcctccg tctcggcggc ctgggccggc agcgacgcct 21600 cgggatcccg gcaccgcagc tcccgtagat cgcgctgggc cctgagggcg tcgaaatgta 21660 cgccccgcaa aaacagacag aagtcctttg gggtcagggt atcgtcgtgt ccccagaagc 21720 gcacgcgtat gcagtttagg gtcagcagca tgtgaaggat gttaaggctg tccgagagac 21780 acgccagcgt gcatctctca aagtagtgtt tgtaacggaa tttgttgtag atgcgcgacc 21840 cccgccccag cgacgtgtcg catgccgacg cgtcacagcg ccccttgaac cggcgacaca 21900 gcaggtttgt gacctgggag aactgcgcgg gccactggcc gcaggaactg accacgtgat 21960 taaggagcat gggcgtaaag acgggctccg agcgcgcccc ggagccgtcc atgtaaatca 22020 gtagctcccc cttgcggagg gtgcgcaccc gtcccaggga ctggtacacg gacaccatgt 22080 ccggtccgta gttcatgggt tttacgtagg cgaacatgcc atcaaagtgc aggggatcga 22140 agctgaggcc cacggttacg accgtcgtgt atataaccac gcggtattgg ccccacgtgg 22200 tcacgtcccc gaggggggtg agcgagtgaa gcaacagcac gcggtccgta aactgacggc 22260 agaaccgggc cacgatctcc gcgaaggaga ccgtcgacga aaaaatgcag atgttatcgc 22320 ccccgccaag gcgcgcttcc agctccccaa agaacgtggc cccccgggcg tccggagagg 22380 cgtccggaga cgggccgctc ggcggcccgg gcgggcgcag ggcagcctgc aggagctcgg 22440 tccccagacg cgggagaaac aggcaccggc gcgccgaaaa cccgggcatg gcgtactcgc 22500 cgaccaccac atgcacgttt ttttcgcccc ggagaccgca caggaagtcc accaactgcg 22560 cgttggcggt tgcgtccatg gcgatgatcc gaggacaggt gcgcagcagg cgtagcatta 22620 acgcatccac gcggcccagt tgctgcatcg ttggcgaata gagctggccc agcgtcgaca 22680 taacctcgtc cagaacgagg acgtcgtagt tgttcagaag gttggggccc acgcgatgaa 22740 ggctttccac ctggacgata agtcggtgga aggggcggtc gttcataatg taattggtgg 22800 atgagaagta ggtgacaaag tcgaccaggc ctgactcagc gaaccgcgtc gccagggtct 22860 gggtaaaact ccgacgacag gagacgacga gcacactcgt gtccggagag tggatcgctt 22920 cccgcagcca gcggatcagc gcggtagttt ttcccgaccc cattggcgcg cggaccacag 22980 tcacgcacct ggccgtcggg gcgctcgcgt tggggaaggt gacgggtccg tgctgctgcc 23040 gctcgatcgt tgttttcggg tgaacccggg gcacccattc ggccaaatcc cccccgtaca 23100 acatccgcgc tagcgatacg ctcgacgtgt actgttcgca ctcgtcgtcc ccaatgggac 23160 gcccggcccc cagaggatct cccgactccg cgccccccac gaaaggcatg accggggcgc 23220 ggacggcgtg gtgggtctgg tgtgtgcagg tggcgacgtt tgtggtctct gcggtctgcg 23280 tcacggggct cctcgtcctg gcctctgtgt tccgggcacg gtttccctgc ttttacgcca 23340 cggcgagctc ttatgccggg gtgaactcca cggccgaggt gcgcgggggt gtagccgtgc 23400 ccctcaggtt ggacacgcag agccttgtgg gcacttatgt aatcacggcc gtgttgttgt 23460 tggccgcggc cgtgtatgcc gtggtcggcg ccgtgacctc ccgctacgac cgcgccctgg 23520 acgcgggccg ccgtctggct gcggcccgca tggccatgcc gcacgccacg ctgatcgccg 23580 gaaacgtctg ctcttggttg ctgcagatca ccgtcctgtt gctggcccat cgcaccagcc 23640 agctggccca cctggtttac gtcctgcact ttgcgtgtct ggtgtatttt gcggcccatt 23700 tttgcaccag gggggtcctg agcgggacgt atctgcgtca ggtgcacggc ctgatggagc 23760 cggccccgac tcatcatcgc gtcgttggcc cggctcgagc cgtgctgaca aacgccttgc 23820 tgttgggcgt cttcctgtgc acggccgacg ccgcggtatc cctgaatacc atcgccgcgt 23880 tcaactttaa tttttcggcc ccgggcatgc tcatatgcct gaccgtgctg ttcgcccttc 23940 tcgtcgtatc gctgttgttg gtggtcgagg gggtgttgtg tcactacgtg cgcgtgttgg 24000 tgggccccca cctgggggcc gtggccgcca cgggcatcgt cggcctggca tgcgagcact 24060 attacaccaa cggctactac gttgtggaga cgcagtggcc gggggcccag acgggagtcc 24120 gcgtcgccct cgccctggtc gccgcctttg ccctcggcat ggccgtgctc cgctgcaccc 24180 gcgcctatct gtatcacagg cggcaccaca ccaaattttt tatgcgcatg cgcgacacgc 24240 gacaccgcgc acattccgcc ctcaagcgcg tacgcagttc catgcgcgga tcgcgagacg 24300 gccgccacag gcccgcaccc ggcagcccgc ccgggattcc cgaatatgcg gaagacccct 24360 acgcgatctc atacggcggc cagctcgacc ggtacggaga ttccgacggg gagccgattt 24420 acgacgaggt ggcggacgac caaaccgacg tattgtacgc caagatacaa cacccgcggc 24480 acctgcccga cgacgagccc atctatgaca ccgttggggg gtacgacccc gagcccgccg 24540 aggaccccgt gtacagcacc gtccgccgtt ggtagctgtt tggttccgtt ttaataaacc 24600 gtttgtgttt aacccgaccg tggtgtatgt ctggtgtgtg gcgtccgatc ccgttactat 24660 caccgttccc cccaaacccc ggcgattgtg ggttttttta aaaacgacac gcgtgcgacc 24720 gtatacagaa cattgttgtt ttttattcgc tatcggacat ggggggtgga aactgggtgg 24780 cggggcaggc gcctccgggg gttcgccggt gagtgtggcg cgagggggga tccgacgaac 24840 gcaggcgctg tctccccggg gcccgcgtaa ccccgcgcat atccgggggc acgtagaaat 24900 taccttcctc ttcggactcg atatccacga cgtcaaagtc gtgggcggtc agcgagacga 24960 cctccccgtc gtcggtgatg aggacgttgt ttcggcagca gcagggccgg gtcccggaga 25020 acgagaggcc catagctcgg cgagcgtgtc gtcgaacgcc aggcggctgc ttcgctgtat 25080 ggccttatag atctccggat cgatgcggac gggggtaatg atcagggcga tcggaacggc 25140 ctggttcggg agaatggacg ccttgctggg tcctgcggcc ccgagagccc cggcgccgtc 25200 ctccaggcgg aacgttacgc cctcctccgc gctagtgcgg tgcctgccga taaacgtcac 25260 cagatgcggg tggggggggc agtcggggaa gtggctgtcg agcacgtagc cctgcaccaa 25320 gatctgctta aagttcgggt gacgggggtt cgcgaagacg ggctcgcggc gtaccagatc 25380 cccggagctc caggacacgg gggagatggt gtggcgtccg aggtcggggg cgccaaacag 25440 aagcacctcc gagacaacgc cgctatttaa ctccaccaag gcccgatccg cggcggagca 25500 ccgccttttt tcgcccgagg cgtgggcctc tgaccaggcc tggtcttgcg tgacgagagc 25560 ctcctccggg ccggggacgc gcccgggcgc gaagtatcgc acgctgggct tcgggatcga 25620 ccggataaat gcccggaacg cctccgggga ccggtgtgcc atcaagtcct cgtacgcgga 25680 ggccgtgggg tcgctggggt ccatggggtc gaaagcgtac ttggcccggc atttgacctc 25740 gtaaaaggcc aggggggtct tggggactgg ggccaagtag ccgtgaatgt cccgaggaca 25800 gacgagaata tccagggacg ccccgaccat ccccgtgtga ccgtccatga ggaccccaca 25860 cgtatgcacg ttctcttcgg cgaggtcgcc gggttcgtgg aagataaagc gccgcgtgtc 25920 ggcgccggcc tcgccgccgt cgtccgcgcg gcccacgcag tagcgaaaca gcaggcttcg 25980 ggccgtcggc tcgttcaccc gcccgaacat caccgccgaa gactgtacat ccggccgcag 26040 gctggcgttg tgcttcagcc actggggcga gaaacacgga ccctgggggc cccagcggag 26100 ggtggatgcg gtcgtgaggc cccgccggag cagggcccat agctggcagt cggcctggtt 26160 ttgcgtggcc gcctcgtaaa accccatgag gggccggggc gccacggcgt ccgcggcggc 26220 cgggggcccg cggcgcgtca ggcgccatag gtgccggccg agtccgcggt ccaccatacc 26280 cgcctcctcg aggaccacgg ccagggaaca cagataatcc aggcgggccc agaggggacc 26340 gatggccaga ggggcgcgga cgccgcgcag caacccgcgc aggtggcgct cgaacgtctc 26400 ggctagtata tgggagggca gcgcgttggg gatcaccgac gccgaccaca tagagtcaag 26460 gtccggggag tcgggatcgg cgtccgggtc gcgggcgtgg gtgcccccag gagatagcgg 26520 aatgtctggg gtcggaggcc ctgaggcgtc agaaagtgcc ggcgacgcgg cccggggctt 26580 ttcgtctgcg gtgtcggtgg cgtgctgatc acgtgggggg ttaacgggcg aatgggagct 26640 cgggtccaca gctgacgtcg tctggggtgg ggggggcagg ggacggaagg tggttgttag 26700 cggaagactg ttagggcggg ggcgcttggg ggggctgtcg gggccacgag gggtgtcctc 26760 ggccagggcc caggaacgct tagtcacggt gcgtcccggc ggacatgctg ggcctcccgt 26820 ggactccatt tccgagacga cgtgggggga gcggtggttg agcgcgccgc cgggtgaacg 26880 ctgattctca cgacagcgcg tgccgcgcgc acgggttggt gtgacacagg cgggacacca 26940 gcaccaggag aggcttaagc tcgggaggca gcgccaccga cgacagtatc gccttgtgtg 27000 tgtgctggta atttatacac cgatccgtaa acgcgcgccg aatcttggga ttgcggaggt 27060 ggcgccggat gccctctggg acgtcatacg ccaggccgtg ggtgttggtc tcggccgagt 27120 tgacaaacag ggctgggtgc agcacgcggc gataggcgag cagggccagg gcgaagtcca 27180 gcgacagctg gttgttgaaa tactggtaac cgggaaaccg ggtcacgggt acgcccaggc 27240 tcggggcgac gtacacgcta accaccaact ccagcagcgt ctggccaagg gcgtacaggt 27300 caaccgctaa cccgacgtcg tgcttcaggc ggtggttggt aaattcggcc cgttcgttgt 27360 taaggtattt caccaacagc tccgggggct ggttataccc gtgacccacc agggtgtgaa 27420 agttggctgt ggttagggcg gtgggcatgc caaacatccg gggggacttg aggtccggct 27480 cctggaggca aaactgcccc cgggcgatcg tggagttgga gttgagggtg acgaggctaa 27540 agtcggcgag gacggcccgc cggagcgaga cggcgtccga ccgcagcatg acgaggatgt 27600 tggcgcactt gatatccagg tggctgatcc cgcaggtggt gtttaaaaac acaacggcgc 27660 gggccagctc cgtgaagcac tggtggaggg ccgtcgagac cgaggggttt gttgtgcgca 27720 gggacgccag ttggccgata tacttaccga ggtccatgtc gtacgcgggg aacactatct 27780 gtcgttgttg cagcgagaac ccgaggggcg cgatgaagcc gcggatgttg tgggtgcggc 27840 cggcgcgtag agcgcactcc ccgaccaaca gggtcgcgat gagctcaacg gcaaaccact 27900 ccttttcctt tatggtctta acggcaagct tatgttcgcg aatcagttgg acgtcgccgt 27960 atcccccaga ccccccgaag cttcgggccc cggggatctc gagggtcgtg tagtgtaggg 28020 cggggttgat ggcgaacacg gggctgcata gcttgcggat gcgcgtgagg gtaaggatgt 28080 gcgaggggga cgaggggggt gcggttaacg ccgcctggga tctgcgcagg ggcgggcggt 28140 tcagtttggc cgccgtaccg ggcgtctcgg gggacgcgcg gcgatgagac gagcggctca 28200 ttcgccatcg ggatagtccc gcgcgaagcc gctcgcggag gccggatcgg tggcgggacc 28260 cgtgggagga gcgggagccg gcggcgtcct ggagagaggg gccgctgggg cgcccggagg 28320 ccccgtgtgg gttggagtgt atgtaggatg cgagccaatc cttgaaggac tgttggcgtg 28380 caccttgggg gctgaggtta gctgccacat gaccagcagg tcgctgtctg cgggactcat 28440 ccatccttcg gccaggtcgc cgtcttccca cagagaagcg ttggtcgctg cttcctcgag 28500 ttgctcctcc tggtccgcaa gacgatcgtc cacggcgtcc aggcgctcac caagcgccgg 28560 atcgaggtac cgtcggtgtg cggttagaaa gtcacgacgc gccgcttgct cctccacgcg 28620 aattttaaca caggtcgcgc gctgtcgcat catctctaag cgcgcgcggg actttagccg 28680 cgcctccaat tccaagtggg ccgcctttgc agccataaag gcgccaacaa accgaggatc 28740 ttgggtgctg acgccctccc ggtgcagctg cagggtctgg tccttgtaaa tctcggctcg 28800 gaggtgcgtc tcggccaggc gtcggcgcag ggccgcgtgg gcggcatctc ggtccattcc 28860 gccaccctgc gggcgacccg gggggtgctc tgatagtctc gcgtgcccaa ggcccgtgat 28920 cggggtactt cgccgccgcg acccgccacc cggtgtgcgc gatgtttggt cagcagctgg 28980 cgtccgacgt ccagcagtac ctggagcgcc tcgagaaaca gaggcaactt aaggtgggcg 29040 cggacgaggc gtcggcgggc ctcacaatgg gcggcgatgc cctacgagtg ccctttttag 29100 atttcgcgac cgcgaccccc aagcgccacc agaccgtggt cccgggcgtc gggacgctcc 29160 acgactgctg cgagcactcg ccgctcttct cggccgtggc gcggcggctg ctgtttaata 29220 gcctggtgcc ggcgcaacta aaggggcgtg atttcggggg cgaccacacg gccaagctgg 29280 aattcctggc ccccgagttg gtacgggcgg tggcgcgact gcggtttaag gagtgcgcgc 29340 cggcggacgt ggtgcctcag cgtaacgcct actatagcgt tctgaacacg tttcaggccc 29400 tccaccgctc cgaagccttt cgccagctgg tgcactttgt gcgggacttt gcccagctgc 29460 ttaaaacctc cttccgggcc tccagcctca cggagaccac gggcccccca aaaaaacggg 29520 ccaaggtgga cgtggccacc cacggccgga cgtacggcac gctggagctg ttccaaaaaa 29580 tgatccttat gcacgccacc tactttctgg ccgccgtgct cctcggggac cacgcggagc 29640 aggtcaacac gttcctgcgt ctcgtgtttg agatccccct gtttagcgac gcggccgtgc 29700 gccacttccg ccagcgcgcc accgtgtttc tcgtcccccg gcgccacggc aagacctggt 29760 ttctagtgcc cctcatcgcg ctgtcgctgg cctcctttcg ggggatcaag atcggctaca 29820 cggcgcacat ccgcaaggcg accgagccgg tgtttgagga gatcgacgcc tgcctgcggg 29880 gctggttcgg ttcggcccga gtggaccacg ttaaagggga aaccatctcc ttctcgtttc 29940 cggacgggtc gcgcagtacc atcgtgtttg cctccagcca caacacaaac gtaagtcctc 30000 ttttctttcg catggctctc ccaaggggcc ccgggtcgac ccgacccaca cccacccacc 30060 cacccacata cacacacaac cagacgcggg aggaaagtct gccccgtggg cactgatttt 30120 tattcgggat cgcttgagga ggcccgggca acggcccggg caacggtggg gcaactcgta 30180 gcaaataggc gactgatgta cgaagagaag acacacaggc gccacccggc gctggtcggg 30240 gggatgttgt ccgcgccgca ccgtcccccg acgacctctt gcagacggtc cgtgatgcaa 30300 ggacggcggg gggcctgcag cagggtgacc gtatccacgg gatggccaaa gagaagcgga 30360 cacaggctag catccccctg gaccgccagg gtacactggg ccatcttggc ccacagacac 30420 ggggcgacgc agggacagga ctccgttacg acggaggaga gccacagtgc gttggcggaa 30480 tcgatgtggg gcggcggggc gcaggactcg cagccccccg ggtggttggt gatcctggcc 30540 aggagccatc ccagatggcg ggccctgctt cccggtggac agagcgaccc caggtcgctg 30600 tccatggccc agcagtagat ctggccgctg gggaggtgcc accaggcccc cgggcccaag 30660 gcgcaacacg cgcccggctc cgggggggtc ttcgcgggga ccagatacgc gccatccagc 30720 tcgccgacca ctggctcctc cgcgagctgt tcggtggttg ggtcgggggt ttcctccggg 30780 ggggtggccg cccgtatgcg ggcgaacgtg agggtgcaca ggagcggggt cagggggtgc 30840 gtcacgctcc ggaggtggac gatcgcgcag tagcggcgct cgcggttaaa gaaaaagagg 30900 gcaaagaagg tgttcggggg caaccgcagc gccttggggc gcgtcagata cagaaaaatc 30960 tcgcagaaga gggcgcgccc ggggtctggg ttaggaaggg ccacctgaca cagaggctcg 31020 gtgaggaccg ttagacaccg aaagatcttg agccgctcgt ccgcccgaac gacgcgccac 31080 acaaagacgg agttgacaat gcgcgcgata gagtcgacgt ccgtccccag gtcgtcgact 31140 ctgtcgcgcg tgccgcgagc tccggcccgg gaatccggcc ggggcaaggt ccccggggga 31200 ccaggcggcg ccaggggccg ccggggtccc agctgcgcca tgccgggggc ggggggaggg 31260 caaaccccag aggcgggggc caacggcgcg gggaggagtg ggtgggcgag gtggccgggg 31320 gaaggcgccc gctagcgaga acggccgttc ccggacgaca ccttgcgaca aaacctaagg 31380 acagcggccc gcgcgacggg gtccgagagg ctaaggtagg ccgcgatgtt aatggtgaac 31440 gcaaagccgc cgggaaagac aactatgcca cagaggcggc gattaaaccc caggcagagg 31500 taggcgtagc tttccccggg caggtattgc tcgcagaccc tgcgtggggc tgtggagggg 31560 acggcctcca tgaagcgaca tttactctgc tcgcgtttac tgacgtcacc atccatcgcc 31620 acggcgattg gacgattgtt aagccgcagc gtgtctccgc ttgtgctgta gtagtcaaaa 31680 acgtaatggc cgtcggagtc ggcaaagcgg gccgggaggt cgtcgccgag cgggacgacc 31740 cgccgccccc gaccgccccg tccccccagg tgtgccagga cggccagggc atacgcggtg 31800 tgaaaaaagg cgtcgggggc ggtcccctcg acggcgcgca tcaggttctc gaggagaatg 31860 gggaagcgcc tggtcacctc ccccagccac gcgcgttggt cggggccaaa gtcatagcgc 31920 aggcgctgtg agattcgagg gccgccctga agcgcggccc ggatggcctg gcccagggcc 31980 cggaggcacg ccagatgtat gcgcgcagta aaggcgacct cggcggcgat gtcaaagggc 32040 ggcaggacgg ggcgcgggtg gcgcaggggc acctcgagcg cgggaaagcg gagcagcagc 32100 tccgcctgcc cagcgggaga cagctggtgg gggcgcacga cgcgttctgc ggcgcaggcc 32160 tcggtcaggg ccgtggccag cgccgaggac agcagcggag ggcgggcgcg tcgcccgccc 32220 cacgccacgg agttctcgta ggagacgacg acgaagcgct gcttggttcc gtagtggtgg 32280 cgcaggacca cggagataga acgacggctc cacagccagt ccggccggtc gccgccggcc 32340 agggcttccc atccgcgatc caaccactcg accagcgacc gcggctttgc ggtaccaggg 32400 gtcagggtta gaacgtcgtt caggatgtcc tcgcccccgg gcccgtgggg cactggggcc 32460 acaaagcggc ccccgcctgg gggctccaga cccgccaaca ccgcatctgc gtcagccgcc 32520 cccatggcgc ccccgctgac ggcctggtga accagggcgc cctggcggag ccccgatgca 32580 acgccacagg ccgcacgccc ggtccgagcg cggaccgggt ggcggcgggt gacgtcctgc 32640 actgcccgct gaaccaacgc gaggatctcc tcgttctcct gcgcgatgga cacgtcctgg 32700 gccgcggtcg tgtcgccgcc gggggccgtc agctgctcct ccggggagat gggggggtcg 32760 gacgccccga cgatgggcgg gtctgcgggc gcccccgcgt ggggccgggc caagggctgc 32820 ggacgcgggg acgcgctttc ccccagaccc atggacaggt gggccgcagc ctccttcgcg 32880 gccggcgggg cggcggcgcc aagcagagcg acgtagcggc acaaatgccg acagacgcgc 32940 atgatgcgcg tgctgtcggc cgcgtagcgc gtgttggggg ggacgagctc gtcgtaacta 33000 aacagaatca cgcgggcaca gctcgccccc gagccccacg caaggcgcag cgccgccacg 33060 gcgtacgggt catagacgcc ctgtgcgtca cacaccacgg gcaaggagac gaacaacccc 33120 ccggcgctgg acgcacgcgg aaggaggcca gggtgtgccg gcacgacggg ggccagaagc 33180 tcccccaccg catccgcggg cacgtaggcg gcaaacgccg tgcaccacgg ggtacagtcg 33240 ccggtggcat gagcccgagt ctggatttcg acctggaagt ttgcggccgt cccgagtccg 33300 gggcggccgc gcatcagggc ggccagaggg attcccgcgg ccgccaggca ctcgctggat 33360 atgatgacgt gaaccaaaga cgagggccga cccgggacgt ggccgagatc gtactggacc 33420 tcgttggcca agtgcgcgtt catggttcgg gggtgggtgt gggtgtgtag gcgatgcggg 33480 tcccccgagt ccgcgggaag ggcgcgggtt tggcgcgcgt atgcgtattc gccaacggag 33540 gcgtgcgtgc ttatgcgcgg cgcgtttctt ctgtctccag ggaatccgag gccaggactt 33600 taacctgctc tttgtcgacg aggccaactt tattcgcccg gatgcggtcc agacgattat 33660 gggctttctc aaccaggcca actgcaagat tatcttcgtg tcgtccacca acaccgggaa 33720 ggccagtacg agctttttgt acaacctccg cggggccgcc gacgagcttc tcaacgtggt 33780 gacctatata tgcgatgatc acatgccgcg ggtggtgacg cacacaaacg ccacggcctg 33840 ttcttgttat atcctcaaca agcccgtttt catcacgatg gacggggcgg ttcgccggac 33900 cgccgatttg tttctggccg attccttcat gcaggagatc atcgggggcc aggccaggga 33960 gaccggcgac gaccggcccg ttctgaccaa gtctgcgggg gagcggtttc tgttgtaccg 34020 cccctcgacc accaccaaca gcggcctcat ggcccccgat ttgtacgtgt acgtggatcc 34080 cgcgttcacg gccaacaccc gagcctccgg gaccggcgtc gctgtcgtcg ggcggtaccg 34140 cgacgattat atcatcttcg ccctggagca cttttttctc cgcgcgctca cgggctcggc 34200 ccccgccgac atcgcccgct gcgtcgtcca cagtctgacg caggtcctgg ccctgcatcc 34260 cggggcgttt cgcggcgtcc gggtggcggt cgagggaaat agcagccagg actcggccgt 34320 cgccatcgcc acgcacgtgc acacagagat gcaccgccta ctggcctcgg agggggccga 34380 cgcgggctcg ggccccgagc ttctcttcta ccactgcgag cctcccggga gcgcggtgct 34440 gtaccccttt ttcctgctca acaaacagaa gacgcccgcc tttgaacact ttattaaaaa 34500 gtttaactcc gggggcgtca tggcctccca ggagatcgtt tccgcgacgg tgcgcctgca 34560 gaccgacccg gtcgagtatc tgctcgagca gctgaataac ctcaccgaaa ccgtctcccc 34620 caacacggac gtccgtacgt attccggaaa acggaacggc gcctcggatg accttatggt 34680 cgccgtcatt atggccatct accttgcggc ccaggccgga cctccgcaca cattcgctcc 34740 catcacacgc gtttcgtgag cgcccaataa acacacccag gtatgctacg cacgaccacg 34800 gtgtcgcctg ttaagggggg gggaaggggg tgttggcggg aagcgtggga acacggggga 34860 ttctctcacg accggcacca gtaccacccc cctgtgaaca cagaaacccc aacccaaatc 34920 ccataaacat acgacacaca ggcatatttt ggaatttctt aggtttttat ttatttaggt 34980 atgctggggt ttctccctgg atgcccaccc ccaccccccc ccgtgggtct agccgggcct 35040 tagggatagc gtataacggg ggccatgtct ccggaccgca caacggccgc gccgtcaaag 35100 gtgcacaccc gaaccacggg agccagggcc aaggtgtctc ctagttggcc cgcgtgggtc 35160 agccaggcga cgagcgcctc gtagagcggc agccttcgct ctccatcctg catcagggcc 35220 ggggcttcgg ggtgaatgag ctgggcggcc tcccgcgtga cactctgcat ctgcaggaga 35280 gcgttcacgt acccgtcctg ggcacttagc gcaaagagcc gggggattag cgtaaggatg 35340 atggtggttc cctccgtgat cgagtaaacc atgttaagga ccagcgatcg cagctcggcg 35400 tttacggggc cgagttgttg gacgtccgcc agcagcgaga ggcgactccc gttgtagtac 35460 agcacgttga ggtctggcag ccctccgggg tttctggggc tggggttcag gtcccggatg 35520 cccctggcca cgagccgcgc cacgatttcg cgcgccaggg gcgatggaag cggaacggga 35580 aaccgcaacg tgaggtccag cgaatccagg cgcacgtccg tcgcttggcc ctcgaacacg 35640 ggcgggacga ggctgatggg gtccccgtta cagagatcta cgggggaggt gttgcgaagg 35700 ttaacggtgc cggcgtgggt gaggcccacg tccagggggc aggcgacgat tcgcgtggga 35760 agcacccggg tgatgaccgc ggggaagcgc cttcggtacg ccagcaacag ccccaacgtg 35820 tcgggactga cgcctccgga gacgaaggat tcgtgcgcca cgtcggccag cgtcagttgc 35880 cggcggatgg tcggcaggaa taccacccgc ccttcgcagc gctgcagcgc cgccgcatcg 35940 gggcgcgaga tgcccgaggg tatcgcgatg tcagtttcaa agccgtccgc cagcatggcg 36000 ccgatccacg cggcagggag tgcagtggtg gttcgggtgg cgggaggagc gcggtggggg 36060 tcagcggcgt agcagagacg ggcgaccaac ctcgcatagg acggggggtg ggtcttaggg 36120 ggttgggagg cgacagggac cccagagcat gcgcggggag gtctgtcggg cccagacgca 36180 ccgagagcga atccgtccat ggagtcccgg cctgggtttt atggggcccg gccctcggaa 36240 tcgcggcttg tcggcgggga caaagggggc ggggctaggg ggcttgcgga aacagaagac 36300 gtgtgggata aaagaatcgc actaccccaa ggaagggcgg ggcggtttat tacagagcca 36360 gtcccttgag cggggatgcg tcatagacga gatactgcgc gaagtgggtc tcccgcgcgt 36420 gggcttcccc gttgcgggcg ctgcggagga gggcggggtc gctggcgcag gtgagcgggt 36480 aggcctcctg aaacaggcca cacgggtcct ccacgagttc gcggcacccc ggggggcgct 36540 taaactgtac gtcgctggcg gcggtggccg tggacaccgc cgaacccgtc tccacgatca 36600 ggcgctccag gcagcgatgt ttggcggcga tgtcggccga cgtaaagaac ttaaagcagg 36660 ggctgagcac cggcgaggcc ccgttgaggt ggtaggcccc gttatagagc aggtccccgt 36720 acgaaaatcg ctgcgacgcc cacgggttgg ccgtggccgc gaaggcccgg gacgggtcgc 36780 tctggccgtg gtcgtacatg agggcggtga catccccctc cttgtccccc gcgtaaacgc 36840 ccccggcggc gcgtccccgg gggttgcagg gccggcggaa gtagttgacg tcggtcgaca 36900 cgggggtggc gataaactca cacacggcgt cctggccgtg gtccatccct gcgcgccgcg 36960 gcacctgggc gcacccgaac acggggacgg gctgggccgg ccccaggcgg tttcccgcca 37020 cgaccgcgtt ccgcaggtac acggctgccg cgttgtccag tagaggggga gccccgcggc 37080 ccaggtaaaa gttttgggga aggttgccca tgtcggtgac ggggttgcgg acggttgccg 37140 tggccacgac ggcggtgtag cccacgccca ggtccacgtt cccgcgcggc tgggtgagcg 37200 tgaagtttac ccccccgcca gtttcatgcc gggccacctg gagctggccc aggaagtacg 37260 cctccgacgc gcgctccgag aacagcacgt tctcagtcac aaagcggtcc tgtcggacga 37320 cggtgaaccc aaacccggga tggaggcccg tcttgagctg atgatgcaag gccacgggac 37380 tgatcttgaa gtaccccgcc atgagcgcgt aggtcagcgc gttctccccg gccgcgctct 37440 cgcggacgtg ctgcacgacg ggctgtcgga tcgacgaaaa gtagttggcc cccagagccg 37500 gggggaccag ggggacctgc cgcgacaggt cgcgcagggc cggggggaaa ttgggcgcgt 37560 tcgccacgtg gtcggccccg gcgaacagcg cgtggacggg gagggggtaa aaatagtcgc 37620 cattttggat ggtatggtcc agatgctggg gggccatcag caggattccg gcgtgcaacg 37680 ccccgtcgaa tatgcgcatg ttggtggtgg acgcggtgtt ggcgcccgcg tcgggcgccg 37740 ccgagcagag cagcgccgtt gtgcgttcgg ccatgttgtg ggccagcacc tgcagcgtga 37800 gcatggcggg cccgtccact accacgcgcc cgttgtgaaa catggcgttg accgtgttgg 37860 ccaccagatt ggccgggtgc agggggtgcg cggggtccgt cacggggtcg ctggggcaat 37920 cctcgccggg ggtgatctcc gggaccacca tgttctgcag ggtggcgtat acgcggtcga 37980 agcgaacccc cgcggtgcag cagcggcccc gcgagaaggc gggcaccatc acgtagtagt 38040 aaatcttgtg gtgcacggtc cagtccgccc cccggtgcgg ccggtcgtcc gcggcgtccg 38100 cggctcgggc ctgggtgttg tgcagcagct ggccgtcgtt gcggttgaag tccgcggtcg 38160 ccacgttaca cgccgctgcg tacacggggt cgtggccccc cgcgctaacc cggcagtcgc 38220 gatggcggtc cagggccgcg cgccgcatca gggcgtcgca gtcccacacg aggggtggca 38280 gcagcgccgg gtctcgcatt aggtgattca gttcggcttg cgcctgcccg cccagttccg 38340 ggccggtcag ggtaaagtca tcaaccagct gggccagggc ctcgacgtgc gccaccaggt 38400 cccggtacac ggccatgcac tcctcgggaa ggtctccccc gaggtaggtc acgacgtacg 38460 agaccagcga gtagtcgttc acgaacgccg cgcaccgcgt gttgttccag tagctggtga 38520 tgcactggac cacgagccgg gccagggcgc agaagacgtg ctcgctgccg tgtatggcgg 38580 cctgcagcag gtaaaacacc gccgggtagt tgcggtcttc gaacgccccg cgaacggcgg 38640 cgatggtggc gggggccatg gcgtggcgtc ccacccccag ctccaggccc cgggcgtccc 38700 ggaacgccgc cggacatagc gccaggggca agttgccgtt caccacgcgc caggtggcct 38760 ggatctcccc cgggccggcc gggggaacgt ccccccccgg cagctccacg tcggccaccc 38820 ccacgaagaa gtcgaacgcg gggtgcagct caagagccag gttggcgttg tcgggctgca 38880 taaactgctc cggggtcatc tggccttccg cgacccatcg gacccgcccg tgggccaggc 38940 gctgccccca ggcgttcaaa aacagctgct gcatgtctgc ggcggggccg gccggggccg 39000 ccacgtacgc cccgtacgga ttggcggctt cgacggggtc gcggttaagg cccccgaccg 39060 ccgcgtcaac gttcatcagc gaagggtggc acacggtccc gatcgcgtgt tccagagaca 39120 ggcgcagcac ctggcggtcc ttcccccaaa aaaacagctg gcggggcggg aaggcgcggg 39180 gatccgggtg gccgggggcg gggactaggt ccccggcgtg cgcggcaaac cgttccatga 39240 ccggattgaa caggcccagg ggcaggacga acgtcaggtc catggcgccc accagggggt 39300 agggaacgtt ggtggcggcg tagatgcgct tctccagggc ctccaaaaag atcagcttct 39360 cgccgatgga caccagatcc gcgcgcacgc gcgtcgtctg gggggcgctc tcgagctcgt 39420 ccagcgtctg ccggttcagg tcgagctgct cctcctgcat ctccagcagg tggcggccca 39480 cgtcgtccag acttcgcacg gccttgccca tcacgagcgc cgtgaccagg ttggccccgt 39540 tcaggaccat ctcgccgtac gtcaccggca cgtcggcttc ggtgtcctcc actttcagga 39600 aggactgcag gaggcgctgt ttgatcgggg cggtggtgac gagcaccccg tcgaccggac 39660 gcccgcgcgt gtcggcatgc gtcagacggg gcacggccac ggagggctgc gtggccgtgg 39720 tgaggtccac gagccaggcc tcgacggcct cccggcggtg gcccgccttg cccaggaaaa 39780 agctcgtctc gcagaagctt cgctttagct cggcgaccag ggtcgcccgg gccaccctgg 39840 tggccaggcg gccgttgtcc aggtatcgtt gcatcggcaa caacaaagcc aggggcggcg 39900 ccttttccag cagcacgtgc agcatctggt cggccgtgcc gcgctcaaac gccccgagga 39960 cggcctggac gttgcgagcg agctgttgga tggcgcgcaa ctggcgatgc gcgctgatac 40020 ccgtcccgtc cagggcctcc cccgtgagca gggcgatggc ctcggtggcc aggctgaagg 40080 cggcgttcag ggcccggcgg tcgataatct tggtcatgta attgtgtgtg ggttgctcga 40140 tggggtgcgg gccgtcgcgg gcaatcagcg gctggtggac ctcgaactgt acgcgcccct 40200 cgttcatgta ggccagctcc ggaaacttgg tacacacgca cgccaccgac aacccgagct 40260 ccagaaagcg cacgagcgac agggtgttgc aatacgaccc caacagggcg tcgaactcga 40320 cgtcatacag gctgtttgca tcggagcgca cgcgggaaaa aaaatcgaac aggcgtcgat 40380 gcgacgccac ctcgatcgtg ctaaggaggg acccggtcgg caccatggcc gcggcatacc 40440 ggtatcccgg agggtcgcgg ttgggagcgg ccatggggtc gcgtggagat cggctgtctc 40500 tagcgatatt ggcccgggga ggctaagatc caccccaacg cccggccacc cgtgtacgtg 40560 cccgacggcc caaggtccac cgaaagacac gacgggcccg gacccaaaaa ggcgggggat 40620 gctgtgtgag aggccgggtg tcggtcgggg gggaaaggca ccgggagaag gctgcggcct 40680 cgttccagga gaacccagtg tccccaacag acccggggac gtgggatccc aggccttata 40740 tacccccccc gccccacccc cgttagaacg cgacgggtgc attcaagatg gccctggtcc 40800 aaaagcgtgc caggaagaaa ttggcagagg cggcaaagct gtccgccgcc gccacccaca 40860 tcgaggcccc ggccgcgcag gctatcccca gggcccgtgt gcgcagggga tcggtgggcg 40920 gcagcatttg gttggtggcg ataaagtgga aaagcccgtc cggactgaag gtctcgtggg 40980 cggcggcgaa caaggcacac agggccgtgc ctcccaaaaa cacggacatc ccccaaaaca 41040 cgggcgccga caacggcaga cgatccctct tgatgttaac gtacaggagg agcgcccgca 41100 ccgcccacgt aacgtagtag ccgacgatgg cggccaggat acaggccggc gccaccaccc 41160 ttccggtcag cccgtaatac atgcccgctg ccaccatctc caacggcttc aggaccaaaa 41220 acgaccaaag gaacagaatc acgcgctttg aaaagaccgg ctgggtatgg ggcggaagac 41280 gcgagtatgc cgaactgaca aaaaagtcag aggtgccgta cgaggacaat gaaaactgtt 41340 cctccagtgg cagttctccc tcctcccccc caaaggcggc ctcgtcgacc agatctcgat 41400 ccaccagagg aaggtcatcc cgcatggtca tggggtgtgc ggtggaggtg gggagaccga 41460 aaccgcaaag ggtcgcttac gtcagcagga tcccgagatc aaagacaccc gggttcttgc 41520 acaaacacca cccgggttgc atccgcggag gcgagtgttt tgataaggcc gttccgcgcc 41580 ttgatataac ctttgatgtt gaccacaaaa cccggaattt acgcctacgc cccaatgccc 41640 acgcaagatg aggtaggtaa cccccccccc gtgggtgtga cgttgcgttt agttcattgg 41700 aggccaaggg gaaaatgggg tggggaggaa acggaaaacc cagtaggccg tgttgggaac 41760 acgcccgggg ttgtcctcaa aaggcagggt ccatactacg gaagccgtcg ttgtattcga 41820 gacctgcctg tgcgacgcac gtcggggttg cctgtgtccg gttcggcccc accgcgtgcg 41880 gcacgcacga ggacgagtcc gcgtgcttta ttggcgttcc aagcgttgcc ctccagtttc 41940 tgttgtcggt gttcccccat acccacgccc acatccaccg tagggggcct ctgggccgtg 42000 tcacgtcgcc gcccgcgatg gagcttagct acgccaccac catgcactac cgggacgttg 42060 tgttttacgt cacaacggac cgaaaccggg cctactttgt gtgcgggggg tgtgtttatt 42120 ccgtggggcg gccgtgtgcc tcgcagcccg gggagattgc caagtttggt ctggtcgttc 42180 gagggacagg cccagacgac cgcgtggtcg ccaactatgt acgaagcgag ctccgacaac 42240 gcggcctgca ggacgtgcgt cccattgggg aggacgaggt gtttctggac agcgtgtgtc 42300 ttctaaaccc gaacgtgagc tccgagctgg atgtgattaa cacgaacgac gtggaagtgc 42360 tggacgaatg tctggccgag tactgcacct cgctgcgaac cagcccgggt gtgctaatat 42420 ccgggctgcg cgtgcgggcg caggacagaa tcatcgagtt gtttgaacac ccaacgatag 42480 tcaacgtttc ctcgcacttt gtgtataccc cgtccccata cgtgttcgcc ctggcccagg 42540 cgcacctccc ccggctcccg agctcgctgg aggccctggt gagcggcctg tttgacggca 42600 tccccgcccc acgccagcca cttgacgccc acaacccgcg cacggatgtg gttatcacgg 42660 gccgccgcgc cccacgaccc atcgccgggt cgggggcggg gtcggggggc gcgggcgcca 42720 agcgggccac cgtcagcgag ttcgtgcaag tcaaacacat tgaccgcgtg ggccccgctg 42780 gcgtttcgcc ggcgcctccg ccaaacaaca ccgactcaag ttccctggtg cccggggccc 42840 aggattccgc cccgcccggc cccacgctaa gggagctgtg gtgggtgttt tatgccgcag 42900 accgggcgct ggaggagccc cgcgccgact ctggcctcac ccgcgaggag gtacgtgccg 42960 tacgtgggtt ccgggagcag gcgtggaaac tgtttggctc cgcgggggcc ccgcgggcgt 43020 ttatcggggc cgcgttgggc ctgagccccc tccaaaagct agccgtttac tactatatca 43080 tccaccgaga gaggcgcctg tcccccttcc ccgcgctagt ccggctcgta ggccggtaca 43140 cacagcgcca cggcctgtac gtccctcggc ccgacgaccc agtcttggcc gatgccatca 43200 acgggctgtt tcgcgacgcg ctggcggccg gaaccacagc cgagcagctc ctcatgttcg 43260 accttctccc cccaaaggac gtgccggtgg gaagcgacgt gcaggccgac agcaccgctc 43320 tgctgcgctt tatagaatcg caacgtctcg ccgtccccgg gggggtgatc tcccccgagc 43380 acgtcgcgta ccttggtgcg ttcctgagcg tgctgtacgc tggccgcggg cgcatgtccg 43440 cagccacgca caccgcgcgg ctgacagggg tgacctccct ggtgctagcg gtgggtgacg 43500 tggaccgtct ttccgcgttt gaccgcggag cggcgggcgc ggccagccgc acgcgggccg 43560 ccgggtacct ggatgtgctt cttaccgttc gtctcgctcg ctcccaacac ggacagtctg 43620 tgtaacagac cccaataaac gtatgtcgct accacaccct tgtgtgtcaa tggacgcctc 43680 tccggggggg aagggaaaac aaagaggggc tgggggagcg gcaccaccgg ggcctgaaca 43740 aacaaaccac agacacggtt acagtttatt cggtcgggcg gagaaacggc cgaagccacg 43800 ccccctttat tcgcgtctcc aaaaaaacgg gacacttgtc cggagaacct ttaggatgcc 43860 agccagggcg gcggtaatca taaccacgcc cagcgcagag gcggccagaa acccgggcgc 43920 aattgcggcc acgggctgcg tgtcaaaggc tagcaaatga atgacggttc cgtttggaaa 43980 tagcaacaag gccgtggacg gcacgtcgct cgaaaacacg cttggggcgc cctccgtcgg 44040 cccggcggcg atttgctgct gtgtgttgtc cgtatccacc agcaacacag acatgacctc 44100 cccggccggg gtgtagcgca taaacacggc ccccacgagc cccaggtcgc gctggttttg 44160 ggtgcgcacc agccgcttgg actcgatatc ccgggtggag ccttcgcatg tcgcggtgag 44220 gtaggttagg aacagtgggc gtcggacgtc gacgccggtg agcttgtagc cgatcccccg 44280 gggcagaggg gagtgggtga cgacgtagct ggcgttgtgg gtgatgggta ccaggatccg 44340 tggctcgacg ttggcagact gccccccgca ccgatgtgag gcctcaggga cgaaggcgcg 44400 gatcagggcg ttgtagtgtg cccagcgcgt cagggtcgag gcgaggccgt gggtctgctg 44460 ggccaggact tcgaccgggg tctcggatcg ggtggcttga gccagcgcgt ccaggataaa 44520 cacgctctcg tctagatcaa agcgcaggga ggccgcgcat ggcgaaaagt ggtccggaag 44580 ccaaaagagg gttttctggt ggtcggcccg ggccagcgcg gtccggaggt cggcgttggt 44640 cgctgcggcg acgtcggacg tacacagggc cgaggctatc agaaggctcc ggcgggcgcg 44700 ttcccgctgc accgccgagg ggacgcccgc caagaacggc tgccggagga cagccgaggc 44760 gtaaaatagc gcccggtgga cgaccggggt ggtcagcacg cggcccccta gaaactcggc 44820 atacagggcg tcgatgagat gggctgcgct gggcgccact gcgtcgtacg ccgaggggct 44880 atccagcacg aaggccagct gatagcccag cgcgtgtaat gccaagctct gttcgcgctc 44940 cagaatctcg gccaccaggt gctggagccg agcctctagc tgcaggcggg ccgtgggatc 45000 caagactgac acattaaaaa acacagaatc cgcggcacag cccgcggccc cgcgggcggc 45060 caacccggca agcgcgcgcg agtgggccaa aaagcctagc aggtcggaga ggcagaccgc 45120 gccgtttgcg tgggcggcgt tcacgaaagc aaaacccgac gtcgcgagca gccccgttag 45180 gcgccagaag agagggggac gcgggccctg ctcggcgccc gcgtcccccg agaaaaactc 45240 cgcgtatgcc cgcgacagga actgggcgta gttcgtgccc tcctccgggt agccgcccac 45300 gcggcggagg gcgtccagcg cggagccgtt gtcggcccgc gtcagggacc ctaggacaaa 45360 gacccgatac cgggggccgc ccgggggccc gggaagagcc cccggggggt tttcgtccgc 45420 ggggtccccg acccgatcta gcgtctggcc cgcggggacc accatcactt ccaccggagg 45480 gctgtcgtgc atggatatca cgagccccat gaattcccgc ccgtagcgcg cgcgcaccag 45540 cgcggcatcg cacccgagca ccagctcccc cgtcgtccag atgcccacgg gccacgtcga 45600 ggccgacggg gagaaataca cgtacctacc tggggatctc aacaggcccc gggtggccaa 45660 ccaggtcgtg gacgcgttgt gcaggtgcgt gatgtccagc tccgtcgtcg ggtgccgccg 45720 ggccccaacc ggcggtcggg ggggcggtgt atcacgcggc ccgctcgggt ggctcgccgt 45780 cgccacgttg tctccccgcg ggaacgtcag ggcctcgggg tcagggacgg ccgaaaacgt 45840 tacccaggcc cgggaacgca gcaacacgga ggcggttgga ttgtgcaaga gacccttaag 45900 gggggcgacc gcggggggag gctgggcggt cggctcgacc gtgatggggg cgggcaggct 45960 cgcgttcggg ggccggccga gcaggtaggt cttcgagatg taaagcagct ggccggggtc 46020 ccgcggaaac tcggccgtgg tgaccaatac aaaacaaaag cgctcctcgt accagcgaag 46080 aaggggcaga gatgccgtag tcaggtttag ttcgtccggc ggcgccagaa atccgcgcgg 46140 tggtttttgg gggtcggggg tgtttggcag ccacagacgc ccggtgttcg tgtcgcgcca 46200 gtacatgcgg tccatgccca ggccatccaa aaaccatggg tctgtctgct cagtccagtc 46260 gtggacctga ccccacgcaa cgcccaaaag aataaccccc acgaaccata aaccattccc 46320 catgggggac cccgtcccta acccacgggg cccgtggcta tggcagggct tgccgccccg 46380 acgttggctg cgagccctgg gccttcaccc gaacttgggg gttggggtgg ggaaaaggaa 46440 gaaacgcggg cgtattggcc ccaatggggt ctcggtgggg tatcgacaga gtgccagccc 46500 tgggaccgaa ccccgcgttt atgaacaaac gacccaacac ccgtgcgttt tattctgtct 46560 ttttatttcc gtcatagcgc gggttccttc cggtattgtc tccttccgtg tttcagttag 46620 cctcccccat ctcccgggca aacgtgcgcg ccaggtcgca gatcgtcggt atggagcctg 46680 gggtggtgac gtgggtctgg accatcccgg aggtaagttg cagcagggcg tcccggcagc 46740 cggcgggcga ttggtcgtaa tccaggataa agacgtgcat gggacggagg cgtttggcca 46800 agacgtccaa ggcccaggca aacacgttat acaggtcgcc gttgggggcc agcaactcgg 46860 gggcccgaaa cagggtaaat aacgtgtccc cgatatgggg tcgtgggccc gcgttgctct 46920 ggggctcggc accctggggc ggcacggccg tccccgaaag ctgtccccaa tcctcccgcc 46980 acgacccgcc gccctgcaga taccgcaccg tattggcaag cagcccgtaa acgcggcgaa 47040 tcgcggccaa catagccagg tcaagccgct cgccggggcg ctggcgtttg gccaggcggt 47100 cgatgtgtct gtcctccgga agggccccca acacgatgtt tgtgccgggc aaggtcggcg 47160 ggatgagggc cacgaacgcc agcacggcct ggggggtcat gctgcccata aggtatcgcg 47220 cggccgggta gcacaggagg gcggcgatgg gatggcggtc gaagatgagg gtgagggccg 47280 ggggcggggc atgtgagctc ccagcctccc ccccgatatg aggagccaga acggcgtcgg 47340 tcacggcata aggcatgccc attgttatct gggcgcttgt cattaccacc gccgcgtccc 47400 cggccgatat ctcaccctgg tcgaggcggt gttgtgtggt gtagatgttc gcgattgtct 47460 cggaagcccc cagcacctgc cagtaagtca tcggctcggg tacgtagacg atatcgtcgc 47520 gcgaacccag ggccaccagc agttgcgtgg tggtggtttt ccccatcccg tgaggaccgt 47580 ctatataaac ccgcagtagc gtgggcattt tctgctccag gcggacttcc gtggcttctt 47640 gctgccggcg agggcgcaac gccgtacgtc ggttgctatg gccgcgagaa cgcgcagcct 47700 ggtcgaacgc agacgcgtgt tgatggcagg ggtacgaagc catacgcgct tctacaaggc 47760 gcttgccaaa gaggtgcggg agtttcacgc caccaagatc tgcggcacgc tgttgacgct 47820 gttaagcggg tcgctgcagg gtcgctcggt gttcgaggcc acacgcgtca ccttaatatg 47880 cgaagtggac ctgggaccgc gccgccccga ctgcatctgc gtgttcgaat tcgccaatga 47940 caagacgctg ggcggggttt gtgtcatcat agaactaaag acatgcaaat atatttcttc 48000 cggggacacc gccagcaaac gcgagcaacg ggccacgggg atgaagcagc tgcgccactc 48060 cctgaagctc ctgcagtccc tcgcgcctcc gggtgacaag atagtgtacc tgtgccccgt 48120 cctggtgttt gtcgcccaac ggacgctccg cgtcagccgc gtgacccggc tcgtcccgca 48180 gaaggtctcc ggtaatatca ccgcagtcgt gcggatgctc cagagcctgt ccacgtatac 48240 ggtccccatg gagcctagga cccagcgagc ccgtcgccgc cgcggcggcg ctgcccgggg 48300 gtctgcgagc agaccgaaaa ggtcacactc tggggcgcgc gacccgcccg agccagcggc 48360 ccgccaggta ccacccgccg accaaacccc cgcctccacg gagggcgggg gggtgcttaa 48420 gaggatcgcg gcgctcttct gcgtgcccgt ggccaccaag accaaacccc gagctgcctc 48480 cgaatgagag tgtttcgttc cttccccctc cccccgcgtc agacaaaccc taaccaccgc 48540 ttaagcggcc cccgcgaggt ccgaagactc atttggatcc ggcgggagcc acctgacaac 48600 agcccccggg tttccccacg ccagacgccg gtccgctgtg ccatcgctcc ccttcatccc 48660 acccccatct tgtccccaaa taaaacaagg tctggtagtt aggacaacga ccgcagttct 48720 cgtgtgttat tgtcgctctc cgcctctcgc agatggaccc gtattgccca tttgacgctc 48780 tggacgtctg ggaacacagg cgcttcatag tcgccgattc ccgaaacttc atcacccccg 48840 agttcccccg ggacttttgg atgtcgcccg tctttaacct cccccgggag acggcggcgg 48900 agcaggtggt cgtcctgcag gcccagcgca cagcggctgc cgctgccctg gagaacgccg 48960 ccatgcaggc ggccgagctc cccgtcgata tcgagcgccg gttacgcccg atcgaacgga 49020 acgtgcacga gatcgcaggc gccctggagg cgctggagac ggcggcggcc gccgccgaag 49080 aggcggatgc cgcgcgcggg gatgagccgg cgggtggggg cgacgggggg gcgcccccgg 49140 gtctggccgt cgcggagatg gaggtccaga tcgtgcgcaa cgacccgccg ctacgatacg 49200 acaccaacct ccccgtggat ctgctacata tggtgtacgc gggccgcggg gcgaccggct 49260 cgtcgggggt ggtgttcggg acctggtacc gcactatcca ggaccgcacc atcacggact 49320 ttcccctgac cacccgcagt gccgactttc gggacggccg gatgtccaag accttcatga 49380 cggcgctggt cctgtccctg cagtcgtgcg gccggctgta tgtgggccag cgccactatt 49440 ccgccttcga gtgcgccgtg ttgtgtctct acctgctgta ccgaaacacg cacggggccg 49500 ccgacgatag cgaccgcgct ccggtcacgt tcggggatct gctgggccgg ctgccccgct 49560 acctggcgtg cctggccgcg gtgatcggga ccgagggcgg ccggccacag taccgctacc 49620 gcgacgacaa gctccccaag acgcagttcg cggccggcgg gggccgctac gaacacggag 49680 cgctggcgtc gcacatcgtg atcgccacgc tgatgcacca cggggtgctc ccggcggccc 49740 cgggggacgt cccccgggac gcgagcaccc acgttaaccc cgacggcgtg gcgcaccacg 49800 acgacataaa ccgcgccgcc gccgcgttcc tcagccgggg ccacaaccta ttcctgtggg 49860 aggaccagac tctgctgcgg gcaaccgcga acaccataac ggccctgggc gttatccagc 49920 ggctcctcgc gaacggcaac gtgtacgcgg accgcctcaa caaccgcctg cagctgggca 49980 tgctgatccc cggagccgtc ccttcggagg ccatcgcccg tggggcctcc gggtccgact 50040 cgggggccat caagagcgga gacaacaatc tggaggcgct atgtgccaat tacgtgcttc 50100 cgctgtaccg ggccgacccg gcggtcgagc tgacccagct gtttcccggc ctggccgccc 50160 tgtgtcttga cgcccaggcg gggcggccgg tcgggtcgac gcggcgggtg gtggatatgt 50220 catcgggggc ccgccaggcg gcgctggtgc gcctcaccgc cctggaactc atcaaccgca 50280 cccgcacaaa ccccaccccc gtgggggagg ttatccacgc ccacgacgcc ctggcgatcc 50340 aatacgaaca ggggcttggc ctgctggcgc agcaggcacg cattggcttg ggctccaaca 50400 ccaagcgttt ctccgcgttc aacgttagca gcgactacga catgttgtac tttttatgtc 50460 tggggttcat tccacagtac ctgtcggcgg tttagtgggt ggtgggcgag gggggagggg 50520 gcattaggga gaaagaacaa gagcctccgt tgggttttct ttgtgcctgt actcaaaagg 50580 tcataccccg taaacggcgg gctccagtcc cggcccggcg gttggcgtga acgcaacggc 50640 gggagctggg ttagcgttta gtttagcatt cgctctcgcc tttccgcccg cccccgaccg 50700 ttgagccttt ttttttttcg tccaccaaag tctctgtggg tgcgcgcatg gcagccgatg 50760 ccccgggaga ccggatggag gagcccctgc cagacagggc cgtgcccatt tacgtggctg 50820 ggtttttggc cctgtatgac agcggggact cgggcgagtt ggcattggat ccggatacgg 50880 tgcgggcggc cctgcctccg gataacccac tcccgattaa cgtggaccac cgcgctggct 50940 gcgaggtggg gcgggtgctg gccgtggtcg acgacccccg cgggccgttt tttgtgggac 51000 tgatcgcctg cgtgcaactg gagcgcgtcc tcgagacggc cgccagcgct gcgattttcg 51060 agcgccgcgg gccgccgctc tcccgggagg agcgcctgtt gtacctgatc accaactacc 51120 tgccctcggt ctccctggcc acaaaacgcc tggggggcga ggcgcacccc gatcgcacgc 51180 tgttcgcgca cgtagcgctg tgcgcgatcg ggcggcgcct tggcactatc gtcacctacg 51240 acaccggtct cgacgccgcc atcgcgccct ttcgccacct gtcgccggcg tctcgcgagg 51300 gggcgcggcg actggccgcc gaggccgagc tcgcgctatc cggacgcacc tgggcgcccg 51360 gcgtggaggc gctgacccac acgctgcttt ccaccgccgt taacaacatg atgctgcggg 51420 accgctggag cctggtggcc gagcggcggc ggcaggccgg gatcgccgga cacacctacc 51480 tccaggcgag cgaaaaattc aaaatgtggg gggcggagcc tgtttccgcg ccggcgcgcg 51540 ggtataagaa cggggccccg gagtccacgg acataccgcc cggctcgatc gctgccgcgc 51600 cgcagggtga ccggtgccca atcgtccgtc agcgcggggt cgcctcgccc ccggtactgc 51660 cccccatgaa ccccgttcca acatcgggca ccccggcccc cgcgccgccc ggcgacggga 51720 gctacctgtg gatcccggcc tcccattaca accagctcgt cgccggccac gccgcgcccc 51780 aaccccagcc gcattccgcg tttggtttcc cggctgcggc gggggccgtg gcctatgggc 51840 ctcacggcgc gggtctttcc cagcattacc ctccccacgt cgcccatcag tatcccgggg 51900 tgctgttctc gggacccagc ccactcgagg cgcagatagc cgcgttggtg ggggccatag 51960 ccgcggaccg ccaggcgggc ggtcagccgg ccgcgggaga ccctggggtc cgggggtcgg 52020 gaaagcgtcg ccggtacgag gcggggccgt cggagtccta ctgcgaccag gacgaaccgg 52080 acgcggacta cccgtactac cccggggagg ctcgaggcgg gccgcgcggg gtcgactctc 52140 ggcgcgcggc ccgccagtct cccgggacca acgagaccat cacggcgctg atgggggcgg 52200 tgacgtctct gcagcaggaa ctggcgcaca tgcgggctcg gaccagcgcc ccctatggaa 52260 tgtacacgcc ggtggcgcac tatcgccctc aggtggggga gccggaacca acaacgaccc 52320 acccggccct ttgtcccccg gaggccgtgt atcgcccccc accacacagc gccccctacg 52380 gtcctcccca gggtccggcg tcccatgccc ccactccccc gtatgcccca gctgcctgcc 52440 cgccaggccc gccaccgccc ccatgtcctt ccacccagac gcgcgcccct ctaccgacgg 52500 agcccgcgtt cccccccgcc gccaccggat cccaaccgga ggcatccaac gcggaggccg 52560 gggcccttgt caacgccagc agcgcagcac acgtggacgt tgacacggcc cgcgccgccg 52620 atttgttcgt ctctcagatg atgggggccc gctgattcgc cccggtcttt ggtaccatgg 52680 gatgtcttac tgtatatctt tttaaataaa ccaggtaata ccaaataaga cccattggtg 52740 tatgttcttt ttttattggg aggggcgggt aggcgggtag ctttacaatg caaaagcctt 52800 tgacgtggag gaaggcgtgg gggggaggaa atcggcactg accaaggggg tccgttttgt 52860 cacgggaaag gaaagaggaa acaggccgcg gacacccggg ggagtttatg tgttcctttt 52920 tctttcttcc cacacacaca caaaaggcgt accaaacaaa aaaaccaaaa gatgcgcatg 52980 cggtttaaca cccgtggttt ttatttacaa caaacccccc gtcacaggtc gtcctcgtcg 53040 gcgtcaccgt ctttgttggg aacttgggtg tagttggtgt tgcggcgctt gcgcatgacc 53100 atgtcggtga ccttggcgct gagcagcgcg ctcgtgccct tcttcttggc cttgtgttcc 53160 gtgcgctcca tggccgacac cagggccatg taccgtatca tctccctggc ctcggctagc 53220 ttggcctcgt caaagtcgcc gccctcctcg ccctccccgg acgcgtccgg gttggtgggg 53280 ttcttgagct ccttggtggt tagagggtac agggccttca tggggttgct ctgcagccgc 53340 atgacgtaac gaaaggcgaa gaaggccgcc gccaggccgg ccaggaccaa cagacccacg 53400 gccagcgccc caaaggggtt ggacatgaag gaggacacgc ccgacacggc cgataccacg 53460 ccgcccacga tgcccatcac caccttgccg accgcgcgcc ccaggtcgcc catcccctcg 53520 aagaacgcgc ccaggcccgc gaacatggcg gcgttggcgt cggcgtggat gaccgtgtcg 53580 atgtcggcga agcgcaggtc gtgcagctgg ttgcggcgct ggacctccgt gtagtccagc 53640 aggccgctgt ccttgatctc gtggcgggtg tacacctcca gggggacaaa ctcgtgatcc 53700 tccagcatgg tgatgttgag gtcgatgaag gtgctgacgg tggtgatgtc ggcgcggctc 53760 agctggtggg agtacgcgta ctcctcgaag tacacgtagc ccccaccgaa ggtgaagtag 53820 cgccggtgtc ccacggtgca cggctcgatc gcatcgcgcg tcagccgcag ctcgttgttc 53880 tcccccagct gcccctcgac caacgggccc tggtcttcgt accgaaagct gaccaggggg 53940 cggctgtagc aggccccggg ccgcgagctg atgcgcatcg agttttggac gatcacgttg 54000 tccgcggcga ccggcacgca cgtggagacg gccatcacgt cgccgagcat ccgcgcgctc 54060 acccgccggc ccacggtgac cgaggcgatg gcgttggggt tcagcttgcg ggcctcgttc 54120 cacagggtca gctcgtgatt ctgtagctcg caccacgcga tggcaacgcg gcccaacata 54180 tcgttgacat ggcgctgtat gtggttgtac gtaaactgca gccgggcgaa ctcgatggag 54240 gaggtggtct tgatgcgctc cacggacgcg ttggcgctgg ccccgggcgg cgggggcgtg 54300 gggtttgggg gcttgcggct ctgctctcgg aggtgttccc gcacgtacag ctccgcgagc 54360 gtgttgctga gaaggggctg gtacgcgatc agaaagcccc cattggccag gtagtactgc 54420 ggctggccca ccttgatgtg cgtcgcgttg tacctgcggg cgaagatgcg gtccatggcg 54480 tcgcgggcgt ccttgccgat gcagtccccc aggtccacgc gcgagagcgg gtactcggtc 54540 aggttggtgg tgaaggtggt ggatatggcg tcggaggaga atcggaagga gccgccgtac 54600 tcggagcgca gcatctcgtc cacttcctgc cacttggtca tggtgcagac cgacgggcgc 54660 tttggcaccc agtcccaggc cacggtgaac ttgggggtcg tgagcaggtt ccgggtggtc 54720 ggcgccgtgg cccgggcctt ggtggtgagg tcgcgcgcgt agaagccgtc gacctgcttg 54780 aagcggtcgg cggcgtagct ggtgtgttcg gtgtgcgacc cctcccggta gccgtaaaac 54840 ggggacatgt acacaaagtc gccagtcgcc agcacaaact cgtcgtacgg gtacaccgag 54900 cgcgcgtcca cctcctcgac gatgcagttt accgtcgtcc cgtaccggtg gaacgcctcc 54960 acccgcgagg ggttgtactt gaggtcggtg gtgtgccagc cccggctcgt gcgggtcgcg 55020 gcgttggccg gtttcagctc catgtcggtc tcgtggtcgt cccggtgaaa cgcggtggtc 55080 tccaggttgt tgcgcacgta cttggccgtg gaccgacaga cccccttggc gttgatcttg 55140 tcgatcacct cctcgaaggg gacgggggcg cggtcctcaa agatccccat aaactgggag 55200 tagcggtggc cgaaccacac ctgcgaaacg gtgacgtctt tgtagtacat ggtggccttg 55260 aacttgtacg gggcgatgtt ctccttgaag accaccgcga tgccctccgt gtagttctga 55320 ccctcgggcc gggtcgggca gcggcgcggc tgctcgaact gcaccaccgt ggcgcccgtg 55380 gggggtgggc acacgtaaaa gtttgcatcg gtgttctccg ccttgatgtc ccgcaggtgc 55440 tcgcgcaggg tggcgtggcc cgcggcgacg gtcgcgttgt cgccggcggg gcgtggtggc 55500 gttgggtttt tcggtttttt gttcttcttc ggtttcgggt cccccgttgg ggcggcgcca 55560 agggcgggcg gcgccggagt ggcagggccc ccgttcgccg cctgggtcgc ggccgcgacc 55620 ccaggcgtgc cgggggaact cggagccgcc gacgccacca ggacccccag cgtcaacccc 55680 aagagcgccc atacgacgaa ccaccggcgc ccccacgagg gggcgccctg gtgcatggcg 55740 ggactacggg ggcccgtcgt gccccccgtc aggtagcctg ggggcgaggt gctggaggac 55800 cgagtagagg atcgagaaaa cgtcgcggtc gtagaccacg accgaccggg ggccgataca 55860 gccgtcgggg gcgctctcga cgatggccac cagcggacag tcggagtcgt acgtgagata 55920 tacgccgggc gggtaacggt aacgaccttc ggaggtcggg cggctgcagt ccgggcggcg 55980 caactcgagc tccccgcacc ggtagaccga ggcaaagagt gtggtggcga taatcagctc 56040 gcgaatatat cgccaggcgg cgcgctgagt gggcgttatt ccggaaatgc cgtcaaaaca 56100 gtaaaacctc tgaaattcgc tgacggccca atcagcaccc gagccccccg cccccatgat 56160 gaaccgggcg agctcctcct tcaggtgcgg caggagcccc acgttctcga cgctgtaata 56220 cagcgcggtg ttggggggct gggcgaagct gtgggtggag tgatcaaaga ggggcccgtt 56280 gacgagctcg aagaagcgat gggtgatgct ggggagcagg gccgggtcca cctggtgtcg 56340 caggagagac gctcgcatga accggtgcgc gtcgaacacg cccggcgccg agcggttgtc 56400 gatgaccgtg cccgcgcccg ccgtcagggc gcagaagcgc gcgcgcgccg caaagccgtt 56460 ggcgaccgcg gcgaacgtcg cgggcagcac ctcgccgtgg acgctgaccc gcagcatctt 56520 ctcgagctcc ccgcgctgct cgcggacgca gcgccccagg ctggccaacg accgcttcgt 56580 caggcggtcc gcgtacagcc gccgtcgctc ccgtacgtcc gcggccgctt gcgtggcgat 56640 gtccccccac gtctcgggcc cctgcccccc gggcccgcgg cgacggtctt cgtcctcgcc 56700 cccgcccccg ggagctccca acccccgtgc cccttcctct acggcgacac ggtccccgtc 56760 gtcgtcgggg cccgcgccgc ccttgggcgc gtccgccgcg ccccccgccc ccatgcgcgc 56820 cagcacgcga cgcagcgcct cctcgtcgca ctgttcgggg ctgacgaggc gccgcaagag 56880 cggcgtcgtc aggtggtggt cgtagcacgc gcggatgagc gcctcgatct gatcgtcggg 56940 tgacgtggcc tgaccgccga ttattagggc gtccaccata tccagcgccg ccaggtggct 57000 cccgaacgcg cgatcgaaat gctccgcccg ccgcccgaac agcgccagtt ccacggccac 57060 cgcggcggtc tcctgctgca actcgcgccg cgccagcgcg gtcaggttgc tggcaaacgc 57120 gtccatggtg gtctggccgg cgcggtcgcc ggacgcgagc cagaatcgca attcgctgat 57180 ggcgtacagg ccgggcgtgg tggcctgaaa cacgtcgtgc gcctccagca gggcgtcggc 57240 ctccttgcgg accgagtcgt tctcgggcga cgggtggggc tgcccgtcgc cccccgcggt 57300 ccgggccagc gcatggtcca acacggagag cgcccgcgcg cggtcggcgt ccgacagccc 57360 ggcggcgtgg ggcaggtacc gccgcagctc gttggcgtcc agccgcacct gcgcctgctg 57420 ggtgacgtgg ttacagatac ggtccgccag gcggcgggcg atcgtcgccc cctggttcgc 57480 cgtcacacac agttcctcga aacagaccgc gcaggggtgg gacgggtcgc taagctccgg 57540 ggggacgata aggcccgacc ccaccgcccc caccataaac tcccgaacgc gctccagcgc 57600 ggcggtggcg ccgcgcgagg gggtgatgag gtggcagtag tttagctgct ttagaaagtt 57660 ctcgacgtcg tgcaggaaac acagctccat atggacggtc ccgccatacg tatccagcct 57720 gacccgttgg tgatacggac agggtcgggc caggcccatg gtctcggtga aaaacgccgc 57780 gacgtctccc gcggtcgcga acgtctccag gctgcccagg agccgctcgc cctcgcgcca 57840 cgcgtactct agcagcaact ccagggtgac cgacagcggg gtgagaaagg ccccggcctg 57900 ggcctccagg cccggcctca gacgacgccg cagcgcccgc acctgaagcg cgttcagctt 57960 cagttggggg agcttccccc gtccgatgtg ggggtcgcac cgccggagca gctctatctg 58020 aaacacatag gtctgcacct gcccgagcag ggctaacaac ttttgacggg ccacggtggg 58080 ctcggacacc ggggcggcca tctcgcggcg ccgatctgta ccgcggccgg agtatgcggt 58140 ggaccgaggc ggtccgtacg ctacccggtg tctggctgag ccccggggtc cccctcttcg 58200 gggcggcctc ccgcgggccc gccgaccggc aagccgggag tcggcggcgc gtgcgtttct 58260 gttctattcc cagacaccgc ggagaggaat cacggcccgc ccagagatat agacacggaa 58320 cacaaacaag cacggatgtc gtagcaataa tttattttac acacattccc cgccccgccc 58380 taggttcccc caccccccaa cccctcacag catatccaac gtcaggtctc cctttttgtc 58440 ggggggcccc tccccaaacg ggtcatcccc gtggaacgcc cgtttgcggc cggcaaatgc 58500 cggtcccggg gcccccgggc cgccgaacgg cgtcgcgttg tcgtcctcgc agccaaaatc 58560 cccaaagtta aacacctccc cggcgttgcc gagttggctg actagggcct cggcctcgtg 58620 cgccacctcc agggccgcgt ccgtcgacca ctcgccgttg ccgcgctcca gggcacgcgc 58680 ggtcagctcc atcatctcct cgcttaggta ctcgtcctcc aggagcgcca gccagtcctc 58740 gatctgcagc tgctgggtgc ggggccccag gcttttcacg gtcgccacga acacgctact 58800 ggcgacggcc gccccgccct cggagataat gccccggagc tgctcgcaca gcgagctttc 58860 gtgcgctccg ccgccgaggt tcgaggccgc gcacacaaac ccggcccggg gacaggccag 58920 gacgaacttg cgggtgcggt caaaaataag gagcgggcac gcgtttttgc cgcccatcag 58980 gctggcccag ttcccggcct gaaacacacg gtcgttgccg gccatgccgt agtatttgct 59040 gatgctcaac cccaacacga ccatggggcg cgccgccatg acgggccgca gcaggttgca 59100 gctggcgaac atggacgtcc acgcgcccgg atgcgcgtcc acggcgtcca tcagcgcgcg 59160 ggccccggcc tccaggcccg ccccgccctg cgcggaccac gcggccgccg cctgcacgct 59220 ggggggacgg cgggaccccg cgatgatggc cgtgagggtg ttgatgaagt atgtcgagtg 59280 atcgcagtac cgcagaatct ggtttgccat gtagtacatc gccagctcgc tcacgttgtt 59340 gggggccagg ttaataaagt ttatcgcgcc gtagtccagg gaaaactttt taatgaacgc 59400 gatggtctcg atgtcctcgc gcgacaggag ccgggcggga agctggttgc gttggagggc 59460 cgtccagaac cactgcgggt tcggctggtt ggaccccggg ggcttgccgt tggggaagat 59520 ggccgcgtgg aactgcttca gcagaaagcc cagcggtccg aggaggatgt ccacgcgctt 59580 gtcgggcttc tggtaggcgc tctggaggct ggcgacccgc gccttggcgg cctcggacgc 59640 gttggcgctc gcgcccgcga acaacacgcg gctcttgacg cgcagctcct tgggaaaccc 59700 cagggtcacg cgggcaacgt cgccctcgaa gctgctctcg gcgggggccg tctggccggc 59760 cgttaggctg ggggcgcaga tagccgcccc ctccgagagc gcgaccgtca gcgttttggc 59820 cgacagaaac ccgttgttaa acatgtccat cacgcgccgc cgcagcaccg gttggaattg 59880 attgcgaaag ttgcgcccct cgaccgactg cccggcgaac accccgtggc actggctcag 59940 ggccaggtcc tgatacacgg cgaggttgga tcgccgcccg agaagctgaa gcagggggca 60000 tggcccgcac gcgtacgggt ccagcgtcag ggacatggcg tggttggcct cgcccagacc 60060 gtcgcgaaac ttgaagttcc tcccctccac caggttgcgc atcagctgct ccacctcgcg 60120 gtccacgacc tgcctgacgt tgttcaccac cgtatgcagg gcctcgcggt tggtgatgat 60180 ggtctccagc cgccccatgg ccgtggggac cgcctggtcc acgtactgca gggtctcgag 60240 ttcggccatg acgcgctcgg tcgccgcgcg gtacgtctcc tgcatgatgg tccgggcggt 60300 ctcggatccg tccgcgcgct tcagggccga gaaggcggcg tagtttccca gcacgtcgca 60360 gtcgctgtac atgctgttca tggtcccgaa gacgccgatg gctccgcggg cggcgctggc 60420 gaacttggga tggcgcgccc ggaggcgcat gagcgtcgtg tgtacgcagg cgtggcgcgt 60480 gtcgaaggtg cacaggttgc agggcacgtc ggtctggttg gagtccgcga cgtatcgaaa 60540 cacgtccatc tcctggcgcc cgacgatcac gccgccgtcg cagcgctcca ggtaaaacag 60600 catcttggcc agcagcgccg gggaaaaccc acacagcatg gccaggtgct cgccggcaaa 60660 ttcctgggtt ccgccgacga ggggcgcggt gggccgaccc tcgaacccgg gcaccacgtg 60720 tccctcgcgg tccacctgtg ggttggccgc cacgtgggtc ccgggcacga ggaagaagcg 60780 gtaaaaggag ggtttgctgt ggtcctttgg gtccgccgga ccggcgtcgt ccacctcggt 60840 gagatggagg gccgagttgg tgctaaatac catggccccc acgagtcccg cggcgcgcgc 60900 caggtacgcc ccgacggcgt tggcgcgggc cgcggccgtg tcctggccct cgcacagcgg 60960 ccacgcggag atgtcggtgg gcggctcgtc gaagacggcc atcgacacga tagactcgag 61020 ggccagggcg gcgtctccgg ccatgacgga ggccaggcgc tgttcgaacc cgcccgccgg 61080 gcccttgccg ccgccgtcgc gcccaccccg cggggtctta ccctggctgg cttcgaaggc 61140 cgtgaacgta atgtcggcgg ggagggcggc gccctcgtgg ttttcgtcaa acgccaggtg 61200 ggcggccgcg cgggccacgg cgtccacgtt tcggcatcgc agtgccacgg cggcgggtcc 61260 cacgaccgcc tcgaacagga ggcggttgag ggggcggtta aaaaacggaa gcgggtaggt 61320 aaaattctcc ccgatcgatc ggtggttggc gttgaacggc tcggcgatga cccggctaaa 61380 atccggcatg aacagctgca acggatacac gggtatgcgg tgcacctccg ccccgcctat 61440 ggttaccttg tccgagcctc ccaggtgcag aaaggtgttg ttgatgcaca cggcctcctt 61500 gaagccctcg gtaacgacca gatacaggag ggcgcggtcc gggtccaggc cgaggcgctc 61560 acacagcgcc tcccccgtcg tctcgtgttt gaggtcgccg ggccgggggg tgtagtccga 61620 aaagccaaaa tggcggcgtg cccgctcgca gagtcgcgtc aggtttgggg cctgggtgct 61680 ggggtccagg tgccggccgc cgtgaaagac gtacacggac gagctgtagt gcgatggcgt 61740 cagtttcagg gacaccgcgg tacccccgag ccccgtcgtg cgagaaccca cgaccacggc 61800 tacgttggcc tcaaagccgc tctccacggt caggcccacg accaggggcg ccacggcgac 61860 gtcggcatcg ccgctgcgcg ccgacagtaa cgccagaagc tcgatgcctt cggacggaca 61920 cgcgcgagcg tacacgtatc ccaggggccc gggggggacc ttgatggtgg ttgccgtctt 61980 gggctttgtc tccatgtcct cctggcaatc ggtccgcaaa cggaggtaat cccggcacga 62040 cgacggacgc ccgacgaggt atgtctcccg agcgtcaaaa tccggggggg ggggcggcga 62100 cggtcaaggg gagggtggga gaccggggtt ggggaatgaa tccctaccct tcacagacaa 62160 cccccgggta accacggggt gccgatgaac cccggcggct ggcaacgcgg ggtccctgcg 62220 agaggcacag atgcttacgg tcaggtgctc cgggccgggt gcgtctgata tgcggttggt 62280 atatgtacac tttacctggg ggcgtgccgg accgccccag cccctcccac accccgcgcg 62340 tcatcagccg gtgggcgtgg ccgctattat aaaaaaagtg agaacgcgaa gcgttcgcac 62400 tttgtcctaa taatatatat attattagga caaagtgcga acgcttcgcg ttctcacttt 62460 ttttataata gcggccacgc ccaccggcta cgtcacgctc ctgtcggccg ccggcggtcc 62520 ataagcccgg ccggccgggc cgacgcgaat aaaccgggcc gccggccggg gcgccgcgca 62580 gcagctcgcc gcccggatcc gccagacaaa caaggccctt gcacatgccg gcccgggcga 62640 gcctgggggt ccggtaattt tgccatccca cccaagcggc ttttggggtt tttcctcttc 62700 ccccctcccc acatcccccc tctttagggg ttcgggtggg aacaaccgcg atgttttccg 62760 gtggcggcgg cccgctgtcc cccggaggaa agtcggcggc cagggcggcg tccgggtttt 62820 ttgcgcccgc cggccctcgc ggagccggcc ggggaccccc gccttgtttg aggcaaaact 62880 tttacaaccc ctacctcgcc ccagtcggga cgcaacagaa gccgaccggg ccaacccagc 62940 gccatacgta ctatagcgaa tgcgatgaat ttcgattcat cgccccgcgg gtgctggacg 63000 aggatgcccc cccggagaag cgcgccgggg tgcacgacgg tcacctcaag cgcgccccca 63060 aggtgtactg cgggggggac gagcgcgacg tcctccgcgt cgggtcgggc ggcttctggc 63120 cgcggcgctc gcgcctgtgg ggcggcgtgg accacgcccc ggcggggttc aaccccaccg 63180 tcaccgtctt tcacgtgtac gacatcctgg agaacgtgga gcacgcgtac ggcatgcgcg 63240 cggcccagtt ccacgcgcgg tttatggacg ccatcacacc gacggggacc gtcatcacgc 63300 tcctgggcct gactccggaa ggccaccggg tggccgttca cgtttacggc acgcggcagt 63360 acttttacat gaacaaggag gaggttgaca ggcacctaca atgccgcgcc ccacgagatc 63420 tctgcgagcg catggccgcg gccctgcgcg agtccccggg cgcgtcgttc cgcggcatct 63480 ccgcggacca cttcgaggcg gaggtggtgg agcgcaccga cgtgtactac tacgagacgc 63540 gccccgctct gttttaccgc gtctacgtcc gaagcgggcg cgtgctgtcg tacctgtgcg 63600 acaacttctg cccggccatc aagaagtacg agggtggggt cgacgccacc acccggttca 63660 tcctggacaa ccccgggttc gtcaccttcg gctggtaccg tctcaaaccg ggccggaaca 63720 acacgctagc ccagccgcgg gccccgatgg ccttcgggac atccagcgac gtcgagttta 63780 actgtacggc ggacaacctg gccatcgagg ggggcatgag cgacctaccg gcatacaagc 63840 tcatgtgctt cgatatcgaa tgcaaggcgg ggggggagga cgagctggcc tttccggtgg 63900 ccgggcaccc ggaggacctg gttattcaga tatcctgtct gctctacgac ctgtccacca 63960 ccgccctgga gcacgtcctc ctgttttcgc tcggttcctg cgacctcccc gaatcccacc 64020 tgaacgagct ggcggccagg ggcctgccca cgcccgtggt tctggaattc gacagcgaat 64080 tcgagatgct gttggccttc atgacccttg tgaaacagta cggccccgag ttcgtgaccg 64140 ggtacaacat catcaacttc gactggccct tcttgctggc caagctgacg gacatttaca 64200 aggtccccct ggacgggtac ggccgcatga acggccgggg cgtgtttcgc gtgtgggaca 64260 taggccagag ccacttccag aagcgcagca agataaaggt gaacggcatg gtgaacatcg 64320 acatgtacgg gatcataacc gacaagatca agctctcgag ctacaagctc aacgccgtgg 64380 ccgaagccgt cctgaaggac aagaagaagg acctgagcta tcgcgacatc cccgcctact 64440 acgccaccgg gcccgcgcaa cgcggggtga tcggcgagta ctgcatacag gattccctgc 64500 tggtgggcca gctgtttttt aagtttttgc cccatctgga gctctcggcc gtcgcgcgct 64560 tggcgggtat taacatcacc cgcaccatct acgacggcca gcagatccgc gtctttacgt 64620 gcctgctgcg cctggccgac cagaagggct ttattctgcc ggacacccag gggcgattta 64680 ggggcgccgg gggggaggcg cccaagcgtc cggccgcagc ccgggaggac gaggagcggc 64740 cagaggagga gggggaggac gaggacgaac gcgaggaggg cgggggcgag cgggagccgg 64800 agggcgcgcg ggagaccgcc ggccggcacg tggggtacca gggggccagg gtccttgacc 64860 ccacttccgg gtttcacgtg aaccccgtgg tggtgttcga ctttgccagc ctgtacccca 64920 gcatcatcca ggcccacaac ctgtgcttca gcacgctctc cctgagggcc gacgcagtgg 64980 cgcacctgga ggcgggcaag gactacctgg agatcgaggt gggggggcga cggctgttct 65040 tcgtcaaggc tcacgtgcga gagagcctcc tcagcatcct cctgcgggac tggctcgcca 65100 tgcgaaagca gatccgctcg cggattcccc agagcagccc cgaggaggcc gtgctcctgg 65160 acaagcagca ggccgccatc aaggtcgtgt gtaactcggt gtacgggttc acgggagtgc 65220 agcacggact cctgccgtgc ctgcacgttg ccgcgacggt gacgaccatc ggccgcgaga 65280 tgctgctcgc gacccgcgag tacgtccacg cgcgctgggc ggccttcgaa cagctcctgg 65340 ccgatttccc ggaggcggcc gacatgcgcg cccccgggcc ctattccatg cgcatcatct 65400 acggggacac ggactccata tttgtgctgt gccgcggcct cacggccgcc gggctgacgg 65460 ccatgggcga caagatggcg agccacatct cgcgcgcgct gtttctgccc cccatcaaac 65520 tcgagtgcga aaagacgttc accaagctgc tgctgatcgc caagaaaaag tacatcggcg 65580 tcatctacgg gggtaagatg ctcatcaagg gcgtggatct ggtgcgcaaa aacaactgcg 65640 cgtttatcaa ccgcacctcc agggccctgg tcgacctgct gttttacgac gataccgtat 65700 ccggagcggc cgccgcgtta gccgagcgcc ccgcagagga gtggctggcg cgacccctgc 65760 ccgagggact gcaggcgttc ggggccgtcc tcgtagacgc ccatcggcgc atcaccgacc 65820 cggagaggga catccaggac tttgtcctca ccgccgaact gagcagacac ccgcgcgcgt 65880 acaccaacaa gcgcctggcc cacctgacgg tgtattacaa gctcatggcc cgccgcgcgc 65940 aggtcccgtc catcaaggac cggatcccgt acgtgatcgt ggcccagacc cgcgaggtag 66000 aggagacggt cgcgcggctg gccgccctcc gcgagctaga cgccgccgcc ccaggggacg 66060 agcccgcccc ccccgcggcc ctgccctccc cggccaagcg cccccgggag acgccgtcgc 66120 atgccgaccc cccgggaggc gcgtccaagc cccgcaagct gctggtgtcc gagctggccg 66180 aggatcccgc atacgccatt gcccacggcg tcgccctgaa cacggactat tacttctccc 66240 acctgttggg ggcggcgtgc gtgacattca aggccctgtt tgggaataac gccaagatca 66300 ccgagagtct gttaaaaagg tttattcccg aagtgtggca ccccccggac gacgtggccg 66360 cgcggctccg ggccgcaggg ttcggggcgg tgggtgccgg cgctacggcg gaggaaactc 66420 gtcgaatgtt gcatagagcc tttgatactc tagcatgagc cccccgtcga agctgatgtc 66480 cctcatttta caataaatgt ctgcggccga cacggtcgga atctccgcgt ccgtgggttt 66540 ctctgcgttg cgccggacca cgagcacaaa cgtgctctgc cacacgtggg cgacgaaccg 66600 gtaccccggg cacgcggtga gcatccggtc tatgagccgg tagtgcaggt gggcggacgt 66660 gccgggaaag atgacgtaca gcatgtggcc cccgtaagtg gggtccgggt aaaacaacag 66720 ccgcgggtcg cacgccccgc ctccgcgcag gatcgtgtgg acgaaaaaaa gctcgggttg 66780 gccaagaatc ccggccaaga ggtcctggag gggggcgttg tggcggtcgg ccaacacgac 66840 caaggaggcc aggaaggcgc gatgctcgaa tatcgtgttg atctgctgca cgaaggccag 66900 gattagggcc tcgcggctgg tggcggcgaa ccgcccgtct cccgcgttgc acgcgggaca 66960 gcaacccccg atgcctaggt agtagcccat cccggagagg gtcaggcagt tgtcggccac 67020 ggtctggtcc agacagaagg gcagcgacac gggagtggtc ttcaccaggg gcaccgagaa 67080 cgagcgcacg atggcgatct cctcggaggg cgtctgggcg agggcggcga aaaggccccg 67140 atagcgctgg cgctcgtgta aacacagctc ctgtttgcgg gcgtgaggcg gcaggctctt 67200 ccgggaggcc cgacgcacca cgcccagagt cccgccggcc gcagaggagc acgaccgccg 67260 gcgctccttg ccgtgatagg gcccgggccg ggagccgcgg cgatgggggt cggtatcata 67320 cataggtaca cagggtgtgc tccagggaca ggagcgagat cgagtggcgt ctaagcagcg 67380 cgcccgcctc acggacaaat gtggcgagcg cggtgggctt tggtacaaat acctgatacg 67440 tcttgaaggt gtagatgagg gcacgcaacg ctatgcagac acgcccctcg aactcgttcc 67500 cgcaggccag cttggccttg tggagcagca gctcgtcggg atgggtggcg gggggatggc 67560 cgaacagaac ccaggggtca acctccatct ccgtgatggc gcacatgggg tcacagaaca 67620 tgtgcttaaa gatggcctcg ggccccgcgg cccgcagcag gctcacaaac cggcccccgt 67680 ccccgggctg cgtctcgggg tccgcctcga gctggtcgac gacgggtacg atacagtcga 67740 agaggctcgt gttgttttcc gagtagcgga ccacggaggc ccggagtctg cgcagggcca 67800 gccagtaagc ccgcaccagt aacaggttac acagcaggca ttctccgccg gtgcgcccgc 67860 gcccccggcc gtgtttcagc acggtggcca tcagagggcc caggtcgagg tcgggctggg 67920 catcgggttc ggtaaactgc gcaaagcgcg gagccacgtc gcgcgtgcgt gccccgcgat 67980 gcgcttccca ggactggcgg accgtggcgc gacgggcctc cgcggcagcg cgcagctggg 68040 gccccgactc ccagacggcg ggggtgccgg cgaggagcag caggaccaga tccgcgtacg 68100 cccacgtatc cggcgactcc tccggctcgc ggtccccggc gaccgtctcg aattccccgt 68160 tgcgagcggc ggcgcgcgta cagcagctgt ccccgccccc gcgccgaccc tccgtgcagt 68220 ccaggagacg ggcgcaatcc ttccagttca tcagcgcggt ggtgagcgac ggctgcgtgc 68280 cggatcccgc cgccgacccc gccccctcct cgcccccgga ggccaaggtt ccgatgaggg 68340 cccgggtggc agactgcgcc aggaacgagt agttggagta ctgcaccttg gcggctcccg 68400 gggagggcga gggcttgggt tgcttctggg catgccgccc gggcaccccg ccgtcggtac 68460 ggaagcagca gtggagaaaa aagtgccggt ggatgtcgtt tatggtgagg gcaaagcgtg 68520 cgaaggagcc gaccagggtc gccttcttgg tgcgcagaaa gtggcggtcc atgacgtaca 68580 caaactcgaa cgcggccacg aagatgctag cggcgcagtg gggcgccccc aggcatttgg 68640 cacagagaaa cgcgtaatcg gccacccact ggggcgagag gcggtaggtt tgcttgtaca 68700 gctcgatggt gcggcagacc agacagggcc ggtccagcgc gaaggtgtcg atggccgccg 68760 cggaaaaggg cccggtgtcc aaaagcccct ccccacaggg atccgggggc gggttgcggg 68820 gtcctccgcg cccgcccgaa ccccctccgt cgcccgcccc cccgcgggcc cttgaggggg 68880 cggtgaccac gtcggcggcg acgtcctcgt cgagcgtacc gacgggcggc acacctatca 68940 cgtgactggc cgccaggagc tcggcgcaga gagcctcgtt aagagccagg aggctgggat 69000 cgaaggccac atacgcgcgc tcgaacgccc ccgccttcca gctgctgccg ggggactctt 69060 cgcacaccgc gacgctcgcc aggaccccgg ggggcgaagt tgccatggct gggcgggagg 69120 ggcgcacgcg ccagcgaact ttacgggaca caatccccga ctgcgcgctg cggtcccaga 69180 ccctggagag tctagacgcg cgctacgtct cgcgagacgg cgcgcatgac gcggccgtct 69240 ggttcgagga tatgaccccc gccgagctgg aggttgtctt cccgactacg gacgccaagc 69300 tgaactacct gtcgcggacg cagcggctgg cctccctcct gacgtacgcc gggcctataa 69360 aagcgcccga cgacgccgcc gccccgcaga ccccggacac cgcgtgtgtg cacggcgagc 69420 tgctcgcccg caagcgggaa agattcgcgg cggtcattaa ccggttcctg gacctgcacc 69480 agattctgcg gggctgacgc gcgcgctgtt gggcgggacg gttcgcgaac cctttggtgg 69540 gtttacgcgg gcacgcacgc tcccatcgcg ggcgccatgg cgggactggg caagccctac 69600 cccggccacc caggtgacgc cttcgagggt ctcgttcagc gaattcggct tatcgtccca 69660 tctacgttgc ggggcgggga cggggaggcg ggcccctact ctccctccag cctcccctcc 69720 aggtgcgcct ttcagtttca tggccatgac gggtccgacg agtcgtttcc catcgagtat 69780 gtactgcggc ttatgaacga ctgggccgag gtcccgtgca acccttacct gcgcatacag 69840 aacaccggcg tgtcggtgct gtttcagggg ttttttcatc gcccacacaa cgcccccggg 69900 ggcgcgatta cgccagagcg gaccaatgtg atcctgggct ccaccgagac gacggggctg 69960 tccctcggcg acctggacac catcaagggg cggctcggcc tggatgcccg gccgatgatg 70020 gccagcatgt ggatcagctg ctttgtgcgc atgccccgcg tgcagctcgc gtttcggttc 70080 atgggccccg aagatgccgg acggacgaga cggatcctgt gccgcgccgc cgagcaggct 70140 attacccgtc gccgccgaac ccggcggtcc cgggaggcgt acggggccga ggccgggctg 70200 ggggtggctg gaacgggttt ccgggccagg ggggacggtt ttggcccgct ccccttgtta 70260 acccaagggc cctcccgccc gtggcaccag gccctgcggg gtcttaagca cctacggatt 70320 ggcccccccg cgctcgtttt ggcggcggga ctcgtcctgg gggccgctat ttggtgggtg 70380 gttggtgctg gcgcgcgcct ataaaaaagg acgcaccgcc gccctaatcg ccagtgcgtt 70440 ccggacgcct tcgccccaca cagccctccc gtccgacacc cccatatcgc ttcccgacct 70500 ccggtcccga tggccgtccc gcaatttcac cgccccagca ccgttaccac cgatagcgtc 70560 cgggcgcttg gcatgcgcgg gctcgtcttg gccaccaata actctcagtt tatcatggat 70620 aacaaccacc cgcaccccca gggcacccaa ggggccgtgc gggagtttct ccgcggtcag 70680 gcggcggcgc tgacggacct tggtctggcc cacgcaaaca acacgtttac cccgcagcct 70740 atgttcgcgg gcgacgcccc ggccgcctgg ttgcggcccg cgtttggcct gcggcgcacc 70800 tattcaccgt ttgtcgttcg agaaccttcg acgcccggga ccccgtgagg cccggggagt 70860 tccttctggg gtgttttaat caataaaaga ccacaccaac gcacgagcct tgcgtttaat 70920 gtcgtgttta ttcaagggag tgggataggg ttcgacggtt cgaaacttaa cacacaaaat 70980 aatcgagcgc gtctagccca gtaacatgcg cacgtgatgt aggctggtca gcacggcgtc 71040 gctgtgatga agcagcgccc ggcgggtccg ctgtaactgc tgttgtaggc ggtaacaggc 71100 gcggatcagc accgccaggg cgctacgacc ggtgcgttgc acgtagcgtc gcgacagaac 71160 tgcgtttgcc gatacgggcg gggggccgaa ttgtaagcgc gtcacctctt gggagtcatc 71220 ggcggataac gcactgaatg gttcgttggt tatgggggag tgtggttccc gagggagtgg 71280 gtcgagcgcc tcggcctcgg aatccgagag gaacaacgag gtggtgtcgg agtcttcgtc 71340 gtcagagaca tacagggtct gaagcagcga cacgggcggg ggggtagcgt caatgtgtag 71400 cgcgagggag gatgcccacg aagacacccc agacaaggag ctgcccgtgc gtggatttgt 71460 ggacgacgcg gaagccggga cggatgggcg gttttgcggt gcccggaacc gaaccgccgg 71520 atactccccg ggtgctacat gcccgttttg gggctggggt tggggctggg gctggggttg 71580 gggttggggc tggggttggg gctggggttg gggctggggt tggggttggg gttggggctg 71640 gggttggggt tggggctggg gctggggctg gggctggggc tggggctggg gctggggctg 71700 gggctggggc tggggctggg gctggggctg gggctggggt tggggctggg gttggggctg 71760 gggcgcggac aggcggttga cggtcaaatg cccccggggg cgcgcagatg tggtgggcgt 71820 ggccaccggc tgccgtgtag tggggcggcg ggaaaccggg cctccgggcg taacaccgcc 71880 ctccagcgtc aagtatgtgg ggggcgggcc tgacgtcggg ggcggggtga cgggttggac 71940 cgcgggaggc gggggagagg gacctgcggg agaggatgag gtcggctcgg ccgggttgcg 72000 gcctaaaaca ggggccgtgg ggtcggcggg gtcccagggt gaagggaggg attcccgcga 72060 ttcggacagc gacgcgacag cggggcgcgt aaggcgccgc tgcggcccgc ctacgggaac 72120 cctggggggg gttggcgcgg gacccgaggt tagcgggggg cggcggtttt cgcccccggg 72180 caaaaccgtg ccggttgcga ccgggggcgg aacgggatcg atagggagag cgggagaagc 72240 ctggccggcg aactggggac cgagcgggag gggcacacca gacaccaaag cgtggagcgc 72300 tggctctggg ggtttgggag gggccggggg gcgcgcgaaa tcggtaaccg gggcgaccgt 72360 gtcggggagg gcaggcggcc gccaaccctg ggtggtcgcg gaagcctggg tggcgcgcgc 72420 cagggagcgt gcccggcggt gtcggcgcgc gcgcgacccg gacgaagaag cggcagaagc 72480 gcgggaggag gcgggggggc ggggggcggt ggcatcgggg ggcgccgggg aactttgggg 72540 ggacggcaag cgccggaagt cgtcgcgggg gcccacgggc gccggccgcg tgctttcggc 72600 cgggacgccc ggtcgtgctt cgcgagccgt gactgccggc ccagggggcc gcggtgcaca 72660 ctgggacgtg gggacggact gatcggcggt gggcgaaagg gggtccgggg caaggagggg 72720 cgcggggccg ccggagtcgt cagacgcgag ctcctccagg ccgtgaatcc atgcccacat 72780 gcgagggggg acgggctcgc cgggggtggc gtcggtgaat agcgtggggg ccaggcttcc 72840 gggccccaac gagccctccg tcccaacaag gtccgccggg ccgggggtcg ggttcgggac 72900 cgaggggctc tggtcgtcgg gggcgcgctg gtacaccgga tgccccggga atagctcccc 72960 cgacaggagg gaggcgtcga acggccgccc gaggatagct cgcgcgagga aggggtcctc 73020 gtcggtggcg ctggcggcga ggacgtcctc gccgcccgcc acaaacggga gctcctcggt 73080 ggcctcgctg ccaacaaacc gcacgtcggg ggggccgggg gggtccgggt tttcccacaa 73140 caccgcgacc ggggtcatgg agatgtccac gagcaccaga cacggcgggc cccgggcgag 73200 gggccgctcg gcgatgagcg cggacaggcg cgggagctgt gccgccagac acgcgttttc 73260 aatcgggttc aggtcggcgt gcaggaggcg gacggcccac gtctcgatgt cggacgacac 73320 ggcatcgcgc aaggcggcgt ccggcccgcg agcgcgtgag tcaaacagcg tgagacacag 73380 ctccagctcc gactcgcggg aaaaggccgt ggtgttgcgg agcgccacga cgacgggcgc 73440 gcccaggagc actgccgcca gcaccaggtc catggccgta acgcgcgccg cgggggtgcg 73500 gtgggtggcg gcggccggca cggcgacgtg ctggcccgtg ggccggtaga gggcgttggg 73560 gggagcgggg ggtgacgcct cgcgcccccc cgaggggctc agcgtctgcc cagattccag 73620 acgcgcggtc agaagggcgt cgaaactgtc atactctgtg tagtcgtccg gaaacatgca 73680 ggtccaaaga gcggccagag cggtgcttgg gagacacatg cgcccgagga cgctcaccgc 73740 cgccagcgcc tgggcgggac tcagctttcc cagcgcggcg ccgcgctcgg ttcccagctc 73800 ggggaccgag cgccagggcg ccagggggtc ggtttcggac aacttgccgc ggcgccagtc 73860 tgccagccgc gtgccgaaca tgaggccccg ggtcggaggg cctccggtcg aaaacactgg 73920 cagcacgcgg atgcgggcgt ctggatgcgg ggtcaggcgc tgcacgaata gcatggaatc 73980 tgctgcgttc tgaaacgcac gggggagggt gagatgcatg tactcgtgtt ggcggaccag 74040 atccaggcgc caaaaggtgt aaatgtgttc cggggagctg gccaccagcg ccaccagcac 74100 gtcgttctcg ttaaaggaaa cgcggtgcct agtggagctg tggggcccga gcggcggtcc 74160 cggggccgcc gcgtcacccc cccattccag ctgggcccag cgacacccaa actcgcgcgt 74220 gagagtggtc gcgacgaggg cgacgtagag ctcggccgcc gcatccatcg aggcccccca 74280 tctcgcctgg cggtggcgca caaagcgtcc gaagagctga aagttggcgg cctgggcgtc 74340 gctgagggcc agctgaagcc ggttgatgac ggtgatgacg tacatggccg tgacggtcga 74400 ggccgactcc agggtgtccg tcggaagcgg ggggcgaatg catgccgcct cgggacacat 74460 cagcagcgcg ccgagcttgt cggtcacggc cgggaagcag agcgcgtact gcagtggcgt 74520 tccatccggg accaaaaagc tgggggcgaa cggccgatcc agcgtactgg tggcctcgcg 74580 cagcaccagg ggccccgggc ctccgctcac tcgcaggtac gcctcgcccc ggcggcgcag 74640 catctgcggg tcggcctctt ggccgggtgg ggcggacgcc cgggcgcggg cgtctagggc 74700 gcgaagatcc acgagcaggg gcgcgggcgc ggcggccgcg cccgcgcccg tctggcctgt 74760 ggccttggcg tacgcgctat ataagcccat gcggcgttgg atgagctccc gcgcgccccg 74820 gaactcctcc accgcccatg gggccaggtc cccggccacc gcgtcgaatt ccgccaacag 74880 gccccccagg gtgtcaaagt tcatctccca ggccaccctt ggcaccacct cgtcccgcag 74940 ccgggcgctc aggtcggcgt gttgggccac gcgccccccg agctcctcca cggccccggc 75000 ccgctcggcg ctcttggcgc ccaggacgcc ctggtacttg gcgggaaggc gctcgtagtc 75060 ccgctgggct cgcagccccg acacagtgtt ggtggtgtcc tgcagggcgc gaagctgctc 75120 gcatgccgcg cgaaatccct cgggcgattt ccaggccccc ccgcgaacgc ggccgaagcg 75180 accccatacc tcgtcccact ccgcctcggc ctcctcgaga gacctccgca gggcctcgac 75240 gcggcgacgg gtgtcgaaga gcgcctgcag gcgcgcgccc tgtcgcgtca ggaggcccgg 75300 gccgtcgccg ctggccgcgt ttagcgggtg cgtctcaaag gtacgctggg catgttccaa 75360 ccaggcgacc gcctgcacgt cgagctcgcg cgccttctcc gtctggtcca acagaatttc 75420 gacctgatcc gcgatctcct ccgccgagcg cgcctggtcc agcgtcttgg ccacggtcgc 75480 cgggacggcg accaccttca gcagggtctt cagattggcc agaccctcgg cctcgagctg 75540 ggcccggcgc tcgcgcgcgg ccagcacctc ccgcagcccc gccgtgaccc gctcggtggc 75600 ttcggcgcgc tgctgtttgg cgcgcaccac ggcgtccttg gtatcggcca ggtcctgtcg 75660 ggtcacgaat gcgacgtagt cggcgtacgc cgtgtccttc acggggctct ggtccacgcg 75720 ctccagcgcc gccacgcacg ccaccagcgc gtcctcgctc gggcagggca gggtgacccc 75780 tgcccggaca agctcggcgg ccgccgccgg gtcgttgcgc accgcggata tctcctccgc 75840 ggcggcggcc aggtccagcg ccacgcttcc gatcgcgcgc cgcgcgtcgg cccggagggc 75900 gtccaggcga tcgcggatat ccacgtactc ggcgtagccc ttttgaaaaa acggcacgta 75960 ctggcgcagg gccggcacgc cccccaagtc ttccgacagg tgtaggacgg cctcgtggta 76020 gtcgataaac ccgtcgttcg cctgggcccg ctccagcagc ccccccgcca gccgcagaag 76080 ccgcgccagg ggctcggtgt ccacccgaaa catgtcggcg tacgtgtcgg ccgcggcccc 76140 gaaggccgcg ctccagtcga tgcggtgaat ggctgcgagc ggggggagca tggggtggcg 76200 ctggttctcg ggggtgtatg ggttaaacgc aagggccgtc tccagggcaa gggtcaccgc 76260 cttggcgttg gttcccagcg cctgttcggc ccgctttcgg aagtcccggg ggttgtagcc 76320 gtgcgtgccc gccagcgcct gcaggcgacg gagctcgacc acgtcaaact cggcaccgct 76380 ttccacgcgg tccagcacgg cctccacgtc ggcggcccag cgctcgtggc tactgcgggc 76440 gcgctgggcc gccatcttct ctctcaggtc ggcgatggcg gcctcaagtt cgtcggcgcg 76500 gcgtcgcgtg gcgccgatga cctttcccag ctcctgcagg gcgcgcccgc tgggggagtg 76560 gtccccggcc gtcccttcgg cgtgcaacag gcccccgaac ctgccctcgt ggcccgcgag 76620 gctttcccgc gcgccggtgg tcgcgcgcgt cgcggcctgg atcagggagg catgctctcc 76680 ctccggttgg ttggcggccc ggcgcacctg gacgacaagg tcggctgccg ccgaccctaa 76740 ggtcgtgagc tgggcgatgg ccccccgcgc gtccagggcc aaccgagtcg ccttgacgta 76800 tcccgcggcg ctgtcggcca tggccgctag gaaggccagg ggggaggccg ggtcgctggc 76860 ggccgcgccc agggccgtca ccgcgtcgac caggacgcgg tgcgcccgca cggccgcatc 76920 caccgtcgac gcggggtctg ccgtcgcgac ggcggcgctg ccggcgttga tggcgttcga 76980 gacggcgtgg gctatgatcg gggcgtgatc ggcgaagaac tgcaagagaa acggagtctc 77040 tggggcgtcg gcgaacaggt tcttcagcac caccacgaag ctgggatgca agccagacag 77100 agccgtcgcc gtgtccggag tcgggtgctc cagggcatct cggtactgcc ccagcagccc 77160 ccacatgtcc gcccgcagcg ccgccgtaac ctcagggggc gccccccgaa cggcctcggg 77220 gaggtccgac cagcccgccg gcagggaggc ccgcagggtc gccaggacgg ccggacaggc 77280 ctttagcccc acaaagtcag ggagggggcg caggaccccc tggagtttgt gcaagaactt 77340 ctcccgggcg tcgcgggcca ccttcgcccg ctcccgcgct ccctcgagca ttgcctccag 77400 ggagcgcgcg cgctcccgca aacgggcacg cgcatcgggg gcgagctctg ccgtcagctt 77460 ggcggcatcc atggcccgcg cctgccgcag cgcttcctcg gccatgcgcg tggcctctgg 77520 cgacagcccg ccgtcgtcgg ggtagggcga cgcgccgggc gcaggaacaa aggccgcgtc 77580 gctgtccagc tgctggccca gggccgcatc tagggcgtcg aagcgccgca gctcggccag 77640 acccgagctg cggcgcgcct gctggtcgtt aatgtcgcgg atgctgcgcg ccagctcgtc 77700 cagcggcttg cgttctatca gcccttggtt ggcggcgtcc gtcaggacgg agagccaggc 77760 cgccaggtcc tcgggggcgt ccagcgtctg gccccgctgg atcagatccc gcaacaggat 77820 ggccgtgggg ctggtcgcga tcgggggcgg ggcgggaatg gcggcgcgct gcgcgatgtc 77880 ccgcgtgtgc tggtcgaaga caggcaggga ctcgagcagc tggaccacgg gcacgacggc 77940 ggccgaagcc acgtgaaacc ggcggtcgtt gttgtcgctg gcctgtagag ccttggcgct 78000 gtatacggcc ccccggtaaa agtactcctt aaccgcgccc tcgatcgccc gacgggcctg 78060 ggtccgcacc tcctccagcc gaacctgaac ggcctcgggg cccagggggg gtgggcgcgg 78120 agccccctgc ggggccgccc cggccggggc gggcattacg ccgaggggcc cggcgtgctg 78180 tgagaccgcg tcgaccccgc gagcgagggc gtcgagggcc tcgcgcatct ggcgatcctc 78240 cgcctccacc ctaatctctt cgccacgggc aaatttggcc agagcctgga ctctatacag 78300 aagcggttct gggtgcgtcg gggtggcggg ggcaaaaagg gtgtccgggt gggcctgcga 78360 gcgctccaga agccactcgc cgaggcgtgt atacagattg gccggcgggg ccgcgcgaag 78420 ctgcagctcc aggtccgcga gttccccgta aaaggcgtcc gtctcccgaa tgacatccct 78480 agccacaagg atcagcttcg ccagcgccag gcgaccgatc agagagtttt cgtccagcac 78540 gtgctggacg aggggcagat gggcggccac gtcggccagg ctcaggcgcg tggaggccag 78600 aaagtccccc acggccgttt tccggggcag catgctcagg gtaaactcca gcagggcggc 78660 ggccgggccg gccaccccgg cctgggtgtg cgtccgggcc ccgttctcga tgagaaaggc 78720 gaggacgcgt tcaaagaaaa aaataacaca gagctccagc agccccggag aagccggata 78780 cggcgaccgt aaggcgctga tggtgagccg cgaacacgcg gcgacctcgc gggccagggt 78840 ggcggagcac gcggtgaact taaccgccgt ggcggccacg tttgggtggg cctcgaacag 78900 ctgggcgagg tctgcgcccg ggggctcggg tgagcggcga gtcttcagcg cctcgagggc 78960 ctgtgaggac gccggaacca tgggcccgtc gtcctcgccc gcctcggcga ccggcggccc 79020 ggccgggtcg gggggtgccg aggcgaggac aggctccgga acggaggcgg ggaccgcggc 79080 cccgacgggg gttttgcctt tgggggtgga tttcttcttg gttttggcag ggggggccga 79140 gcgtttcgtt ttctcccccg aagtcaggtc ttcgacgctg gaaggcggag tccaggtggg 79200 tcggcggcgc ttgggaaggc cggccgagta gcgtgcccgg tgccgaccaa ccgggacgac 79260 gcccatctcc aggacccgca tgtcgtcgtc atcttcttcg gccgcctctg cggcgggggt 79320 cttgggggcg gagggaggcg gtggtgggat cgcggagggt gggtcggcgg aggggggatc 79380 cgtgggtggg gtacccttta gggccaccgc ccatacatcg tcgggcgccc gattcgggcg 79440 cttggcctct ggttttgccg acggaccggc cgtcccccgg gatgtctcgg aggccctgtc 79500 gtcgcgacgg gcccgggtcg gtggcggcga ctgggcggct gtgggcgggt gtggccccgg 79560 cccccctccc ccctcccggg ggcccacgcc gacgcagggc tcccccaggc ccgcgatctc 79620 gccccgcagg gggtgcgtga tggccacgcg ccgttcgctg aacgcttcgt cctgcatgta 79680 agtctcgctg gccccgtaaa gatgcagagc cgcggccgtc aagtccgcag gagccgcggg 79740 ttccgggccc gacggcacga aaaacaccat ggctcccgcc caccgtacgt ccgggcgatc 79800 gcgggtgtaa tacgtcaggt atggatacat gtcccccgcc cgcactttgg cgatgaacgc 79860 gggggtgccc tccggaaggc catgcgggtc aaaaaggtat gcggtgtcgc cgtccctgaa 79920 cagccccatc cctagggggc caatggttag gagcgtgtac gacagggggc gcagggccca 79980 cgggccggcg aagaacgtgt gtgcggggca ttgtgtctcc agcaggcctg ccgcgggctc 80040 cccgaagaag cccacctcgc cgtatacgcg cgagaagaca cagcgcagtc cgccgcgcgc 80100 ccctgggtac tcgaggaagt tggggagctc gacgatcgaa cacatgcgcg gcggcccagg 80160 gcccgcagtc gcgcgcgtcc actcgccccc ctcgaccaaa catccctcga tggcctccgc 80220 ggacagaacg tcgcgagggc ccacatcaaa tatgaggctg agaaaggaca gcgacgagcg 80280 catgcacgat accgaccccc ccggctccag gtcgggcgcg aactggttcc gagcaccggt 80340 gaccacgatg tcgcgatccc ccccgcgttc catcgtggag tgcggtgggg tgcccgcgat 80400 catatgtgcc ctgcgggcca gagacccggc ctgtttatgg accggacccc cggggttagt 80460 gttgtttccg ccacccacgc ccccgtacca tggccccggt tcccctgatt aggctacgag 80520 tcgcggtgat cgcttcccaa aaaccgagct gcgtttgtct gtcttggtct tccccccccc 80580 cagcccgcac accataacac cgagaacaac acacgggggt gggcggaaca taataaagct 80640 ttattggtaa ctagttaacg gcaagtccgt gggtggcgcg acggtgtcct ccgggatcat 80700 ctcgtcgtcc tcgacggggg tgttggaatg aggcgcctcc tcgcggtcca cctggcgtgg 80760 gccgtgccca taggcctccg gcttctgtgc gtccatgggc gtaggcgcgg ggagactgtt 80820 tccggcgtcg cggacctcca ggtccctggg agcctccggt ccggctaacg gacgaaacgc 80880 ggaagcgcga aacacgccgt cggtgacccg caggagctcg ttcatcagta accaatccat 80940 actcagcgta acggccagcc cctggcgaga cagatccacg gagtccggaa ccgcggtcgt 81000 ctggcccagg gggccgaggc tgtagtcccc ccaggcccct aggtcgcgac ggctcgtaag 81060 cacgacgcgg tcggccgcgg ggctttgcgg gggggcgtcc tcgggcgcat gcgccattac 81120 ctctcggatg gccgcggcgc gctggtcggc cgagctgacc aagggcgcca cgaccacggc 81180 gcgctccgtc tgcaggccct tccacgtgtc gtggagttcc tggacaaact cggccacggg 81240 ctcgggtccc gcggccgcgc gcgcggcttg atagcaggcc gacagacgcc gccagcgcgc 81300 tagaaactga cccatgaaac aaaacccggg gacctggtct cccgacagca gcttcgacgc 81360 ccgggcgtga atgccggaca cgacggacag aaacccgtga atttcgcgcc ggaccacggc 81420 cagcacgttg tcctcgtgcg acacctgggc cgccagctcg tcgcacaccc ccaggtgcgc 81480 cgtggtttcg gtgatgacgg aacgcaggct cgcgagggac gcgaccagcg cgcgcttggc 81540 gtcgtgatac atgctgcagt actgactcac cgcgtccccc atggcctcgg ggggccaggg 81600 ccccaggcgg tcgggcgtgt ccccgaccac cgcatacagg cggcgcccgt cgctctcgaa 81660 ccgacactcg aaaaaggcgg agagcgtgcg catgtgcagc cgcagcagca cgatggcgtc 81720 ctccagttgg cgaatcaggg ggtcggcgcg ctcggcgagg tcctgcagca ccccccgggc 81780 agccagggcg tacatgctaa tcaacaggag gctggtgccc acctcggggg gcgggggggg 81840 ctgcagttgg accaggggcc gcagctgctc gacggcaccc ctggagatca cgtacagctc 81900 ccggagcagc tgctctatgt tgtcggccat ctgcatagtg gggccgaggc cgccccgggc 81960 ggccggttcg aggagagtga tcagcgcgcc cagtttggtg cgatggccct cgaccgtggg 82020 gagatagccc agcccaaagt cccgggccca ggccaacaca cgcagggcga actcgaccgg 82080 gcggggaagg taggccgcgc tacacgtggc cctcagcgcg tccccaacca ccagggccag 82140 aacgtagggg acgaagcccg ggtcggcgag gacgttgggg tgaatgccct cgagggcggg 82200 gaagcggatc tgggtcgccg cggccaggtg gacagagggg gcatggctgg gctgcccgac 82260 ggggagaagc gcggacagcg gcgtggccgg ggtggtgggg gtgatgtccc agtgggtctg 82320 accatacacg tcgatccaga tgagcgccgt ctcgcggaga aggctgggtt gaccggaact 82380 aaagcggcgc tcggccgtct caaactcccc cacgagcgcc cgccgcaggc tcgccagatg 82440 ttccgtcggc acggccggcc ccatgatacg cgccagcgtc tggctcagaa cgccccccga 82500 caggccgacc gcctcacaga gccgcccgtg cgtgtgctcg ctggcgccct ggacccgcct 82560 gaaagttttt acgtagttgg catagtaccc gtattcccgc gccagaccaa acacgttcga 82620 ccccgcgagg gcaatgcacc caaagagctg ctggacttcg ccgagtccgt ggccggcggg 82680 cgtccgcgcg gggacgcccg ccgccagaaa cccctccagg gccgaaaggt agtgcgtgca 82740 gtgcgagggc gtgaacccag cgtcgatcag ggtgttgatc accacggagg gcgaattggt 82800 attctggatc aacgtccacg tctgctgcag cagagccagc agccgctgct gggcgccggc 82860 ggagggctgc tccccgagct gcagcaggct ggagacggca ggctggaaga ctgccagtgc 82920 cgacgaactc aggaacggca cgtcgggatc aaacacggcc acgtccgtcc gcacgcgcgc 82980 cattagcgtc cccgggggcg cacaggccga gcgcgggctg acgcggctga gggccgtcga 83040 cacgcgcacc tcctcgcggc tgcgaaccat cttgttggcc tccagtggcg gaatcattat 83100 ggccgggtcg atctcccgca cggtgtgctg aaactgcgcc aacaggggcg gcgggaccac 83160 agccccccgc tcgggggtcg tcaggtactc gtccaccagg gccaacgtaa agagggcccg 83220 tgtgagggga gtgagggtcg cgtcgtctat gcgctggagg tgcgccgaga acagcgtcac 83280 ccgattactc accagggcca agaaccggag gccctcttgc acgaacgggg cggggaagag 83340 caggctgtac gccggggtgg taaggttcgc gctgggctgc cccaacggga ccggcgccag 83400 cttgagcgac gtctccccaa gggcctcgat ggaggtccgc gggctcatgg ccaagcagct 83460 cttggtgacg gtttgccagc ggtctatcca ctccacggcg cactggcgga cgcggaccgg 83520 ccccagggcc gccgcggtgc gcaggccggc ggactccagc gcatgggacg tgtcggagcc 83580 ggtgaccgcg aggatggtgt ccttgatgac ctccatctcc cggaaggcct ggtcgggggc 83640 ctcggggaga gccaccacca agcggtgtac gagcaacccg gggaggttct cggccaagag 83700 cgccgtctcc ggaagcccgt gggcccggtg gagcgcgcac aggtgttcca gcagcggccg 83760 ccagcatgcc cgcgcgtctg ccggggcgat ggccgttccc gacaacagaa acgccgccat 83820 ggcggcgcgc agcttggccg tggccagaaa cgccgggtcg tccgccccgt ttgccgtctc 83880 ggccgtgggg gttggcggtt ggcgaaggcc ggctaggctc gccaataggc gctgcatagg 83940 tccgtccgag ggcggaccgg cgggtgaggt cgtgacgacg ggggcctcgg acgggagacc 84000 gcggtctgcc atgacgcccg gctcgcgtgg gtgggggaca gcgtagacca acgacgagac 84060 cgggcgggaa tgactgtcgt gcgctgtagg gagcggcgaa ttatcgatcc cccgcggccc 84120 tccaggaacc ccgcaggcgt tgcgagtacc ccgcgtcttc gcggggtgtt atacggccac 84180 ttaagtcccg gcatcccgtt cgcggaccca ggcccggggg attgtccgga tgtgcgggca 84240 gcccggacgg cgtgggttgc ggactttcgg cggggcggcc caaatggccc tttaaacgtg 84300 tgtatacgga cgcgccgggc cagtcggcca acacaaccca ccggaggcgg tagccgcgtt 84360 tggctgtggg gtgggtggtt ccgccttgcg tgagtgtcct ttcgaccccc cccctccccc 84420 gggtcttgct aggtcgcgat ctgtggtcgc aatgaagacc aatccgctac ccgcaacccc 84480 ttccgtgtgg ggcgggagta ccgtggaact cccccccacc acacgcgata ccgcggggca 84540 gggcctgctt cggcgcgtcc tgcgcccccc gatctctcgc cgcgacggcc cagtgctccc 84600 cagggggtcg ggaccccgga gggcggccag cacgctgtgg ttgcttggcc tggacggcac 84660 agacgcgccc cctggggcgc tgacccccaa cgacgatacc gaacaggccc tggacaagat 84720 cctgcggggc accatgcgcg ggggggcggc cctgatcggc tccccgcgcc atcatctaac 84780 ccgccaagtg atcctgacgg atctgtgcca acccaacgcg gatcgtgccg ggacgctgct 84840 tctggcgctg cggcaccccg ccgacctgcc tcacctggcc caccagcgcg ccccgccagg 84900 ccggcagacc gagcggctgg gcgaggcctg gggccagctg atggaggcga ccgccctggg 84960 gtcggggcga gccgagagcg ggtgcacgcg cgcgggcctc gtgtcgttta acttcctggt 85020 ggcggcgtgt gccgcctcgt acgacgcgcg cgacgccgcc gatgcggtac gggcccacgt 85080 cacggccaac taccgcggga cgcgggtggg ggcgcgcctg gatcgttttt ccgagtgtct 85140 gcgcgccatg gttcacacgc acgtcttccc ccacgaggtc atgcggtttt tcggggggct 85200 ggtgtcgtgg gtcacccagg acgagctagc gagcgtcacc gccgtgtgcg ccgggcccca 85260 ggaggcggcg cacaccggcc acccgggccg gccccgctcg gccgtgatcc tcccggcgtg 85320 tgcgttcgtg gacctggacg ccgagctggg gctggggggc ccgggcgcgg cgtttctgta 85380 cctggtattc acttaccgcc agcgccggga ccaggagctg tgttgtgtgt acgtgatcaa 85440 gagccagctc cccccgcgcg ggttggagcc ggccctggag cggctgtttg ggcgcctccg 85500 gatcaccaac acgattcacg gcaccgagga catgacgccc ccggccccaa accgaaaccc 85560 cgacttcccc ctcgcgggcc tggccgccaa tccccaaacc ccgcgttgct ctgctggcca 85620 ggtcacgaac ccccagttcg ccgacaggct gtaccgctgg cagccggacc tgcgggggcg 85680 ccccaccgca cgcacctgta cgtacgccgc ctttgcagag ctcggcatga tgcccgagga 85740 tagtccccgc tgcctgcacc gcaccgagcg ctttggggcg gtcagcgtcc ccgttgtcat 85800 cctggaaggc gtggtgtggc gccccggcga gtggcgggcc tgcgcgtgag cgtagcaaac 85860 gccccgccca cacaacgctc cgcccccaac cccttccccg ctgtcactcg ttgttcgttg 85920 acccggacgt ccgccaaata aagccactga aacccgaaac gcgagtgttg taacgtcctt 85980 tgggcgggag gaagccacaa aatgcaaatg ggatacatgg aaggaacaca cccccgtgac 86040 tcaggacatc ggcgtgtcct tttgggtttc actgaaactg gcccgcgccc cacccctgcg 86100 cgatgtggat aaaaagccag cgcgggtggt ttagggtacc acaggtgggt gctttggaaa 86160 cttgtcggtc gccgtgctcc tgtgagcttg cgtccctccc cggtttcctt tgcgctcccg 86220 ccttccggac ctgctctcgc ctatcttctt tggctctcgg tgcgattcgt caggcagtgg 86280 ccttgtcgaa tctcgacccc accactcgcc ggacccgccg acgtcccctc tcgagcccgc 86340 cgaaacccgc cgcgtctgtt gaaatggcca gccgccccgc cgcatcctct cccgtcgaag 86400 cgcgggcccc ggttggggga caggaggccg gcggccccag cgcagccacc cagggggagg 86460 ccgccggggc ccctctcgcc cgcggccacc acgtgtactg ccagcgagtc aatggcgtga 86520 tggtgctttc cgacaagacg cccgggtccg cgtcctaccg catcagcgat agcaactttg 86580 tccaatgtgg ttccaactgc accatgatca tagacggaga cgtggtgcgc gggcgccccc 86640 aggacccggg ggccgcggca tcccccgctc ccttcgttgc ggtgacaaac atcggagccg 86700 gcagcgacgg cgggaccgcc gtcgtggcat tcgggggaac cccacgtcgc tcggcgggga 86760 cgtctaccgg tacccagacg accgacgtcc ccaccgaggc ccttgggggc ccccctcctc 86820 ctccccgctt caccctgggt ggcggctgtt gttcctgtcg cgacacacgg cgccgctctg 86880 cggtattcgg gggggagggg gatcccgtcg gccccgcgga gttcgtctcg gacgaccggt 86940 cgtccgattc cgactcggat gactcggagg acaccgactc ggagacgctg tcacacgcct 87000 cctcggacgt gtccggcggg gccacgtacg acgacgccct tgactccgat tcgtcatcgg 87060 atgactccct gcagatagat ggccccgtgt gtcgcccgtg gagcaatgac accgcgcccc 87120 tggatgtttg ccccgggacc cccggcccgg gcgccgacgc cggtggtccc tcagcggtag 87180 acccacacgc accgacgcca ggggccggcg ctggtcttgc ggccgatccc gccgtggccc 87240 gggacgacgc ggaggggctt tcggaccccc ggccacgtct gggaacgggc acggcctacc 87300 ccgtccccct ggaactcacg cccgagaacg cggaggccgt ggcgcgcttt ctgggagatg 87360 ccgtgaaccg cgaacccgcg ctcatgctgg agtacttttg ccggtgcgcc cgcgaggaaa 87420 ccaagcgtgt cccccccagg acattctgca gcccccctcg cctcacggag gacgactttg 87480 ggcttctcaa ctacgcgctc gtggagatgc agcgcctgtg tctggacgtt cctccggtcc 87540 tgccgaacgc atacatgccc tattatctca gggagtatgt gacgcggctg gtcaacgggt 87600 tcaagccgct ggtgagccgg tccgctcgcc tttaccgcat cctgggggtt ctggtgcacc 87660 tgcggatccg gacccgggag gcctcctttg aggagtggct gcgatccaag gaagtggccc 87720 tggactttgg cctgacggaa aggcttcgcg agcacgaagc ccagctggtg atcctggccc 87780 aggctctgga ccattacgac tgtctgatcc acagcacacc gcacacgctg gtcgagcggg 87840 ggctgcaatc ggccctgaag tatgaggagt tttacctaaa gcgctttggc gggcactaca 87900 tggagtccgt cttccagatg tacacccgca tcgccggctt tttggcctgc cgggccacgc 87960 gcggcatgcg ccacatcgcc ctggggcgag aggggtcgtg gtgggaaatg ttcaagttct 88020 ttttccaccg cctctacgac caccagatcg taccgtcgac ccccgccatg ctgaacctgg 88080 ggacccgcaa ctactacacc tccagctgct acctggtaaa cccccaggcc accacaaaca 88140 aggcgaccct gcgggccatc accagcaacg tcagcgccat cctcgcccgc aacgggggca 88200 tcgggctatg cgtgcaggcg tttaacgact ccggccccgg gaccgctagc gtcatacccg 88260 ccctcaaggt cctcgactcg ctggtggcgg cgcacaacaa agagagcgcg cgtccaaccg 88320 gcgcgtgcgt gtacctggag ccgtggcaca ccgacgtgcg ggccgtgctc cggatgaagg 88380 gggtcctcgc cggcgaagag gcccagcgct gcgacaatat cttcagcgcc ctctggatgc 88440 cagacctgtt tttcaagcgc ctgattcgcc acctggacgg cgagaagaac gtcacatgga 88500 ccctgttcga ccgggacacc agcatgtcgc tcgccgactt tcacggggag gagttcgaga 88560 agctctacca gcacctcgag gtcatggggt tcggcgagca gatacccatc caggagctgg 88620 cctatggcat tgtgcgcagt gcggccacga ccgggagccc cttcgtcatg ttcaaagacg 88680 cggtgaaccg ccactacatc tacgacaccc agggggcggc catcgccggc tccaacctct 88740 gcaccgagat cgtccatccg gcctccaagc gatccagtgg ggtctgcaat ctgggaagcg 88800 tgaatctggc ccgatgcgtc tccaggcaga cgtttgactt tgggcggctc cgcgacgccg 88860 tgcaggcgtg cgtgctgatg gtgaacatca tgatcgacag cacgctacaa cccacgcccc 88920 agtgcacccg cggcaacgac aacctgcggt ccatgggaat cggcatgcag ggcctgcaca 88980 cggcctgcct gaagctgggg ctggatctgg agtctgtcga atttcaggac ctgaacaaac 89040 acatcgccga ggtgatgctg ctgtcggcga tgaagaccag caacgcgctg tgcgttcgcg 89100 gggcccgtcc cttcaaccac tttaagcgca gcatgtatcg cgccggccgc tttcactggg 89160 agcgctttcc ggacgcccgg ccgcggtacg agggcgagtg ggagatgcta cgccagagca 89220 tgatgaaaca cggcctgcgc aacagccagt ttgtcgcgct gatgcccacc gccgcctcgg 89280 cgcagatctc ggacgtcagc gagggctttg cccccctgtt caccaacctg ttcagcaagg 89340 tgacccggga cggcgagacg ctgcgcccca acacgctcct gctaaaggaa ctggaacgca 89400 cgtttagcgg gaagcgcctc ctggaggtga tggacagtct cgacgccaag cagtggtccg 89460 tggcgcaggc gctcccgtgc ctggagccca cccaccccct ccggcgattc aagaccgcgt 89520 ttgactacga ccagaagttg ctgatcgacc tgtgtgcgga ccgcgccccc tacgtcgacc 89580 atagccaatc catgaccctg tatgtcacgg agaaggcgga cgggaccctc ccagcctcca 89640 ccctggtccg ccttctggtc cacgcatata agcgcggact aaaaacaggg atgtactact 89700 gcaaggttcg caaggcgacc aacagcgggg tctttggcgg cgacgacaac attgtctgca 89760 cgagctgcgc gctgtgaccg acaaaccccc tccgcgccag gcccgccgcc actgtcgtcg 89820 ccgtcccacg cgctcccccg ctgccatgga ttccgcggcc ccagccctct cccccgctct 89880 gacggcccat acgggccaga gcgcgccggc ggacctggcg atccagattc caaagtgccc 89940 cgaccccgag aggtacttct acacctccca gtgtcccgac attaaccacc tgcgctccct 90000 cagcatcctt aaccgctggc tggaaaccga gcttgttttc gtgggggacg aggaggacgt 90060 ctccaagctt tccgagggcg agctcagctt ttaccgcttc ctcttcgctt tcctgtcggc 90120 cgccgacgac ctggttacgg aaaacctggg cggcctctcc ggcctgtttg agcagaagga 90180 cattctccac tactacgtgg agcaggaatg catcgaagtc gtacactcgc gcgtgtacaa 90240 catcatccag ctggtgcttt ttcacaacaa cgaccaggcg cgccgcgagt acgtggccgg 90300 caccatcaac cacccggcca tccgcgccaa ggtggactgg ctggaagcgc gggtgcggga 90360 atgcgcctcc gttccggaaa agttcatcct catgatcctc atcgagggca tcttttttgc 90420 cgcctcgttt gccgccatcg cctaccttcg caccaacaac cttctgcggg tcacctgcca 90480 gtcaaacgac ctcatcagcc gggacgaggc cgtgcacacg acggcctcgt gttacatcta 90540 caacaactac ctcggcgggc acgccaagcc cccgcccgac cgcgtgtacg ggctgttccg 90600 ccaggcggtc gagatcgaga tcggatttat ccgatcccag gcgccgacgg acagccatat 90660 cctgagcccg gcggcgctgg cggccatcga aaactacgtg cgattcagcg cggatcgcct 90720 gttgggcctt atccacatga agccactgtt ttccgcccca ccccccgacg ccagctttcc 90780 gctgagcctc atgtccaccg acaaacacac caattttttc gagtgtcgca gcacctccta 90840 cgccggggcg gtcgtcaacg atctgtgagg gtcgcggcgc gcttctaccc gtgtttgccc 90900 ataataaacc tctgaaccaa actttgggtc tcattgtgat tcttgtcagg gacgcggggg 90960 tgggagagga taaaaggcgg cgcaaaaagc agtaaccagg tccgtccaga ttctgagggc 91020 ataggatacc ataattttat tggtgggtcg tttgttcggg gacaagcgcg ctcgtctgac 91080 gtttgggcta ctcgtcccag aatttggcca ggacgtcctt gtagaacgcg ggtggggggg 91140 cctgggtccg cagctgctcc agaaacctgt cggcgatatc aggggccgtg atatgccggg 91200 tcacaataga tcgcgccagg ttttcgtcgc ggatgtcctg gtagataggc aggcgtttca 91260 gaagagtcca cggcccccgc tccttggggc cgataagcga tatgacgtac ttaatgtagc 91320 ggtgttccac cagctcggtg atggtcatgg gatcggggag ccagtccagg gactctgggg 91380 cgtcgtggat gacgtggcgt cgccggctgg ccacataact gcggtgctct tccagcagct 91440 gcgcgttcgg gacctggacg agctcgggcg gggtgagtat ctccgaggag gacgacctgg 91500 ggccggggtg gcccccggta acgtcccggg gatccagggg gaggtcctcg tcgtcttcgt 91560 atccgccggc gatctgttgg gttagaattt cggtccacga gacgcgcatc tcggtgccgc 91620 cggcggccgg cggcaaaggg ggcctggttt ccgtggagcg cgagctggtg tgttcccggc 91680 ggatggcccg ccgggtctga gagcgactcg ggggggtcca gtgacattcg cgcagcacat 91740 cctccacgga ggcgtaggtg ttattgggat ggaggtcggt gtggcagcgg acaaagaggg 91800 ccaggaactg ggggtagctc atcttaaagt actttagtat atcgcgacag ttgatcgtgg 91860 gaatgtagca ggcgctaata tccaacacaa tatcacagcc catcaacagg aggtcagtgt 91920 ctgtggtgta cacgtacgcg accgtgttgg tgtgatagag gttggcgcag gcatcgtccg 91980 cctccagctg acccgagtta atgtaggcgt accccagggc ccggagaacg cgaatacaga 92040 acagatgcgc cagacgcagg gccggcttcg agggcgcggc ggacggcagc gcggctccgg 92100 acccggccgt cccccgggtc cccgaggcca gagaggtgcc gcgccggcgc atgttggaaa 92160 aggcagagct gggtctggag tcggtgatgg gggaaggcgg tggagaggcg tccacgtcac 92220 tggcctcctc gtccgtccgg cattgggccg tcgtgcgggc caggatggcc ttggctccaa 92280 acacaaccgg ctccatacaa ttgaccccgc gatcggtaac gaagatgggg aaaagggact 92340 tttgggtaaa cacctttaat aagcgacaga ggcagtgtag cgtaatggcc tcgcggtcgt 92400 aactggggta tcggcgctga tatttgacca ccaacgtgta catgacgttc cacaggtcca 92460 cggcgatggg ggtgaagtac ccggccgggg ccccaaggcc ctggcgcttg accagatggt 92520 gtgtgtgggc aaacttcatc atcccgaaca aacccatgtc aggtcgattg taactgcgga 92580 tcggcctaac taaggcgtgg ttggtgcgac ggtccgggac acccgagcct gtctctctgt 92640 gtatggtgac ccagacaaca acaccgacac aagaggacaa taatccgtta ggggacgctc 92700 tttataattt cgatggccca actccacgcg gattggtgca gcaccctgca tgcgccggtg 92760 tgggccaaac ttccccccgc tcattgcctc ttccaaaagg gtgtggccta acgagctggg 92820 ggcgtattta atcaggctag cgcggcgggc ctgccgtagt ttctggctcg gtgagcgacg 92880 gtccggttgc ttgggtcccc tggctgccag caaaacccca ccctcgcagc ggcatacgcc 92940 ccctccgcgt cccgcacccg agaccccggc ccggctgccc tcaccaccga agcccacctc 93000 gtcactgtgg ggtgttccca gcccgcattg ggatgacgga ttcccctggc ggtgtggccc 93060 ccgcctcccc cgtggaggac gcgtcggacg cgtccctcgg gcagccggag gagggggcgc 93120 cctgccaggt ggtcctgcag ggcgccgaac ttaatggaat cctacaggcg tttgccccgc 93180 tgcgcacgag ccttctggac tcgcttctgg ttatgggcga ccggggcatc cttatccata 93240 acacgatctt tggggagcag gtgttcctgc ccctggaaca ctcgcaattc agtcggtatc 93300 gctggcgcgg acccacggcg gcgttcctgt ctctcgtgga ccagaagcgc tccctcctga 93360 gcgtgtttcg cgccaaccag tacccggacc tacgtcgggt ggagttggcg atcacgggcc 93420 aggccccgtt tcgcacgctg gttcagcgca tatggacgac gacgtccgac ggcgaggccg 93480 ttgagctagc cagcgagacg ctgatgaagc gcgaactgac gagctttgtg gtgctggttc 93540 cccagggaac ccccgacgtt cagttgcgcc tgacgaggcc gcagctcacc aaggtcctta 93600 acgcgaccgg ggccgatagt gccacgccca ccacgttcga gctcggggtt aacggcaaat 93660 tttccgtgtt caccacgagt acctgcgtca catttgctgc ccgcgaggag ggcgtgtcgt 93720 ccagcaccag cacccaggtc cagatcctgt ccaacgcgct caccaaggcg ggccaggcgg 93780 ccgccaacgc caagacggtg tacggggaaa atacccatcg caccttctct gtggtcgtcg 93840 acgattgcag catgcgggcg gtgctccggc gactgcaggt cgccgggggc accctcaagt 93900 tcttcctcac gacccccgtc cccagtctgt gcgtcaccgc caccggtccc aacgcggtat 93960 cggcggtatt tctcctgaaa ccccagaaga tttgcctgga ctggctgggt catagccagg 94020 ggtctccttc agccgggagc tcggcctccc gggcctctgg gagcgagcca acagacagcc 94080 aggactccgc gtcggacgcg gtcagccacg gcgatccgga agacctcgat ggcgctgccc 94140 gggcgggaga ggcgggggcc tcgcacgcct gtccgatgcc gtcgtcgacc acgcgggtca 94200 ctcccacgac caagcggggg cgctcggggg gcgaggatgc gcgcgcggac acggccctaa 94260 agaaacctaa gacggggtcg cccaccgcac ccccgcccac agatccagtc cccctggaca 94320 cggaggacga ctccgatgcg gcggacggga cggcggcccg tcccgccgct ccagacgccc 94380 ggagcggaag ccgttacgcg tgttactttc gcgacctccc gaccggagaa gcaagccccg 94440 gcgccttctc cgccttccgg gggggccccc aaaccccgta tggttttgga ttcccctgac 94500 ggggcggggc cttggcggcc gcccaactct cgcaccatcc cgggttaatg taaataaact 94560 tggtattgcc caacactctc ccgcgtgtcg cgtgtggttc atgtgtgtgc ctggcgtccc 94620 ccaccctcgg gttcgtgtat ttcctttccc tgtccttata aaagccgtat gtggggcgct 94680 gacggaacca ccccgcgtgc catcacggcc aaggcgcggg atgctccgca acgacagcca 94740 ccgggccgcg tccccggagg acggccaggg acgggtcgac gacggacggc cacacctcgc 94800 gtgcgtgggg gccctggcgc gggggttcat gcatatctgg cttcaggccg ccacgctggg 94860 ttttgcggga tcggtcgtta tgtcgcgcgg gccgtacgcg aatgccgcgt ctggggcgtt 94920 cgccgtcggg tgcgccgtgc tgggctttat gcgcgcaccc cctcccctcg cgcggcccac 94980 cgcgcggata tacgcctggc tcaaactggc ggccggtgga gcggcccttg ttctgtggag 95040 tctcggggag cccggaacgc agccgggggc cccgggcccg gccacccagt gcctggcgct 95100 gggcgccgcc tatgcggcgc tcctggtgct cgccgatgac gtctatccgc tctttctcct 95160 cgccccgggg cccctgttcg tcggcaccct ggggatggtc gtcggcgggc tgacgatcgg 95220 aggcagcgcg cgctactggt ggatcggtgg gcccgccgcg gccgccttgg ccgcggcggt 95280 gttggcgggc ccgggggcga ccaccgccag ggactgcttc tccagggcgt gccccgacca 95340 ccgccgcgtc tgcgtcatcg tcgcaggcga gtctgtttcc cgccgccccc cggaggaccc 95400 agagcgaccc ggggaccccg ggccaccgtc ccccccgaca ccccaacgat cccaggggcc 95460 gccggccgat gaggtcgcac cggccggggt agcgcggccc gaaaacgtct gggtgcccgt 95520 ggtcaccttt ctgggggcgg gcgcgctcgc cgtcaagacg gtgcgagaac atgcccggga 95580 aacgccgggc ccgggcctgc cgctgtggcc ccaggtgttt ctcggaggcc atgtggcggt 95640 ggccctgacg gagctgtgtc aggcgcttat gccctgggac cttacggacc cgctgctgtt 95700 tgttcacgcc ggactgcagg tcatcaacct cgggttggtg tttcggtttt ccgaggttgt 95760 cgtgtatgcg gcgctagggg gtgccgtgtg gatttcgttg gcgcaggtgc tggggctccg 95820 gcgtcgcctg cacaggaagg accccgggga cggggcccgg ttggcggcga cgcttcgggg 95880 cctcttcttc tccgtgtacg cgctggggtt tggggtgggg gcgctgctgt gccctccggg 95940 gtcaacgggc gggtggtcgg gcgattgata tatttttcaa taaaaggcat tagtcccgaa 96000 gaccgccggt gtgtgatgat ttcgccataa cacccaaacc ccggatgggg cccgggtata 96060 aattccggaa ggggacacgg gctaccctca ctaccgaggg cgcttggtcg ggaggccgca 96120 tcgaacgcac acccccatcc ggtggtccgt gtggaggtcg tttttcagtg cccggtctcg 96180 ctttgccggg aacgctagcc gatccctcgc gagggggagg cgtcgggcat ggccccgggg 96240 cgggtgggcc ttgccgtggt cctgtggagc ctgttgtggc tcggggcggg ggtggccggg 96300 ggctcggaaa ctgcctccac cgggcccacg atcaccgcgg gagcggtgac gaacgcgagc 96360 gaggccccca catcggggtc ccccgggtca gccgccagcc cggaagtcac ccccacatcg 96420 accccaaacc ccaacaatgt cacacaaaac aaaaccaccc ccaccgagcc ggccagcccc 96480 ccaacaaccc ccaagcccac ctccacgccc aaaagccccc ccacgtccac ccccgacccc 96540 aaacccaaga acaacaccac ccccgccaag tcgggccgcc ccactaaacc ccccgggccc 96600 gtgtggtgcg accgccgcga cccattggcc cggtacggct cgcgggtgca gatccgatgc 96660 cggtttcgga attccacccg catggagttc cgcctccaga tatggcgtta ctccatgggt 96720 ccgtcccccc caatcgctcc ggctcccgac ctagaggagg tcctgacgaa catcaccgcc 96780 ccacccgggg gactcctggt gtacgacagc gcccccaacc tgacggaccc ccacgtgctc 96840 tgggcggagg gggccggccc gggcgccgac cctccgttgt attctgtcac cgggccgctg 96900 ccgacccagc ggctgattat cggcgaggtg acgcccgcga cccagggaat gtattacttg 96960 gcctggggcc ggatggacag cccgcacgag tacgggacgt gggtgcgcgt ccgcatgttc 97020 cgccccccgt ctctgaccct ccagccccac gcggtgatgg agggtcagcc gttcaaggcg 97080 acgtgcacgg ccgccgccta ctacccgcgt aaccccgtgg agtttgtctg gttcgaggac 97140 gaccgccagg tgtttaaccc gggccagatc gacacgcaga cgcacgagca ccccgacggg 97200 ttcaccacag tctctaccgt gacctccgag gctgtcggcg gccaggtccc cccgcggacc 97260 ttcacctgcc agatgacgtg gcaccgcgac tccgtgatgt tctcgcgacg caatgccacc 97320 gggctggccc tggtgctgcc gcggccaacc atcaccatgg aatttggggt ccggcatgtg 97380 gtctgcacgg ccggctgcgt ccccgagggc gtgacgtttg cctggttcct gggggacgac 97440 ccctcaccgg cggctaagtc ggccgttacg gcccaggagt cgtgcgacca ccccgggctg 97500 gctacggtcc ggtccaccct gcccatttcg tacgactaca gcgagtacat ctgtcggttg 97560 accggatatc cggccgggat tcccgttcta gagcaccacg gcagtcacca gcccccaccc 97620 agggacccca ccgagcggca ggtgatcgag gcgatcgagt gggtggggat tggaatcggg 97680 gttctcgcgg cgggggtcct ggtcgtaacg gcaatcgtgt acgtcgtccg cacatcacag 97740 tcgcggcagc gtcatcggcg gtaacgcgag acccccccgt taccttttta atatctatat 97800 agtttggtcc ccctctatcc cgcccaccgc tgggcgctat aaagccgcca ccctctcttc 97860 cctcaggtca tccttggtcg atcccgaacg acacacggcg tggagcaaaa cgcctccccc 97920 tgagccgctt tcctaccaac acaacggcat gcctctgcgg gcatcggaac acgcctaccg 97980 gcccctgggc cccgggacac cccccatgcg ggctcggctc cccgccgcgg cctgggttgg 98040 cgtcgggacc atcatcgggg gagttgtgat cattgccgcg ttggtcctcg tgccctcgcg 98100 ggcctcgtgg gcactttccc catgcgacag cggatggcac gagttcaacc tcgggtgcat 98160 atcctgggat ccgaccccca tggagcacga gcaggcggtc ggcggctgta gcgccccggc 98220 gaccctgatc ccccgcgcgg ctgccaaaca gctggccgcc gtcgcacgcg tccagtcggc 98280 aagatcctcg ggctactggt gggtgagcgg agacggcatt cgggcctgcc tgcggctcgt 98340 cgacggcgtc ggcggtattg accagttttg cgaggagccc gcccttcgca tatgctacta 98400 tccccgcagt cccgggggct ttgttcagtt tgtaacttcg acccgcaacg cgctggggct 98460 gccgtgaggc gcgtgtactg cggtctgtct cgtctcctct tctccccttc cctccccctc 98520 cgcatcccag gatcacaccg gccaacgagg gttggggggg tccggcacgg acccaaaata 98580 ataaacacac aatcacgtgc gataaaaaga acacgcggtc ccctgtggtg tttttggtta 98640 tttttattaa atctcgtcga caaacagggg gaaaggggcg tggtctagcg acggcagcac 98700 gggcggaggc gttcaccggc tccggcgtcc ttcgcgttta agcttggtca ggagggcgct 98760 cagggcggcg acgttggtcg ggccgtcgtt ggtcagggcg ttggctcgat ggcgggcgag 98820 gacgggcgag gggctcaacg gcgggggcgg gggtccggtg cggcccgggg gggaaaatag 98880 ggcggatccc ccccagtcgt acaggggatt ttccgcctca atgtacgggg aggccggcgc 98940 tgcattcgcc gtgttcacgc agacgttttc gtagacccgc atccatggta tttcctcgta 99000 gacacgcccc ccgtcctcgc tcacggtctc gtatattgac tcgtcgtcct cgtagggggc 99060 gtgccgttcg cgggccgagg cggcgtgggt ggctttgcgg cgggcgtcgt cgtcgtcgtc 99120 gtcggccgtc agatacgtgg cttccatctg gtcgggttct ccctccgggg cgggtcccca 99180 cacccgtggc cgatcgaggc tccccagaga cgcgcgccgg acaagaaggg ggcacgtcgc 99240 cgccggcggt cgcctgtcgg gtcccgcgac gttacgggcc gggaggcgcg ggggcacctc 99300 ccccatgtgc gtgtaatacg tggccggctg tgcggccgca gcggggggct cggcgaccgg 99360 gtcgtccgca tccggaagcg ggggccccgc gccgtccgca cggcgcctcc ggaaccgccg 99420 ggtggacggc gcgggggtcg agtgtaggcg aggtcggggg aggggcgggg gctcgttgtc 99480 gcgccgcgcc cgctgaatct tttcccgaca ggtcccaccc cccgcgcgat gcccccccgg 99540 gccgcgggcc atgtcgtccg ggggaggccc cgcggaccac gtcgtccggc gagacgccac 99600 gagccgcagg atggactcgt agtggagcga cggcgccccg ctgcggagca gatccgcggc 99660 cagggcggcc ccgaaccaag ccttgatgct caactccatc cgggcccagc tgggggcggt 99720 catcgtgggg aacagggggg cggtggtccg acagaaacgc tcctggctgt ccaccgcggc 99780 ccgcagatac tcgttgttca ggctgtcggt ggcccagacg ccgtacccgg tgagggtcgc 99840 gttgatgata tactgggcgt ggtgatggac gatcgacaga acctccaccg tggataccac 99900 ggtatccacg gtcccgtacg taccgccgct ccgcttgccg gtctgccaca ggttggctag 99960 gcacgtcagg tggcccagga cgtcgctgac cgccgccctg agcgccatgc actgcatgga 100020 gccggtcgtg ccgctgggac cccggtccag atggcgcgcg aacgtttccg cgggcgcctc 100080 cgggctgccg ccgagcggga ggaaccggcg attggaggga ctcagccggt gacatacgtg 100140 cttgtccgtc gtccacagca tccaggacgc ccaccggtac agcacggaga cgtaggccag 100200 gagctcgttg agccgcagtg cggtgtcggt gctggggcgg cttgggtccg ccgggcgcat 100260 aaagaacatg tactgctgaa tccgatggag ggcgtcgcgc aggccggcca cggtggcggc 100320 gtacttggcc gccgcggccc cgctcttgaa cggggtgcgc gccagcagct ttggcgccag 100380 ggtgggccgc agcagcacgt gaaggctggg gtcgcagtcg cccacggggt cctcggggac 100440 gtccaggccg ctgggcacca ccgtctgcag gtacttccag tactgcgtga ggatggcgcg 100500 gctcaactgg ccgccgggca gctccacctc gcccagcgcc tgggtggcgg ccgaagcgta 100560 gtgccggatg tactcgtagt gcgggtcgct ggcgagcccg tccacgatca aactctcggg 100620 aaccgtgttg tgttgccgcg cggccaaccg gacgctgcga tcggtgcagg tcagaaacgc 100680 cggctgcgcg tcgtcggagc gctgccgcaa ggcgcccacg gccgcgctaa ggagcccctc 100740 cggggtgggg agcagacacc cgccgaagat gcgccgctcg ggaacgcccg cgttgtcgcc 100800 gcggatcagg ttggcaggcg tcaggcaccg cgccagccgc agggagctcg cgccgcgcgt 100860 ccggcgctgc atggtgacgc ccgttcggtc gggacccgcc ggtcggagtt atgccgcgtc 100920 cagggccatc ggggcgcttt ttatcgggag gagcttatgg gcgtggcggg cctcccagcc 100980 cggtcgcgcg cctccccgac acgtgcgccc gcagggcggc ggccccctcg tctcccatca 101040 gcagtttcct aaactgggac atgatgtcca ccacgcggac ccgcgggccc aacacggacc 101100 cgccgcttac gggggcgggg gggaagggct ccaggtcctt gagcagaaag gcggggtctg 101160 ccgtcccgga cacgggggcc cggggcgcgg aggaggcggg gcgcagatcc acgtgctccg 101220 cggccgcgcg gacgtccgcc cagaacttgg cgggggtggt gcgcgcgtac aggggctggg 101280 tcgctcggag gacacacgcg tagcgcaggg gggtgtacgt gcccacctcg ggggccgtga 101340 atcccccgtc aaacgcggcc agtgtcacgc acgccaccac ggtgtcggca aagcccagca 101400 gccgctgcag gacgagcccg gcggccagaa tggcgcgcgt ggtcgcagcg tcgtcccggc 101460 gccggtgcgc gtccccgcac gcccgggcgt actttaaggt cactgtcgcc agggccgtgt 101520 gcagcgcgta caccgcagcg cccagcacgg cgttgagccc gctgttggcg agcagccggc 101580 gcgctgcggt gtcgcccagc gcctcgtgct cggcccccac gaccgcgggg cttcccaggg 101640 gcagggcgcg aaacagctcc tcccgcgcca cgtccgcaaa ggcggggtgg tgcacgtgcg 101700 ggtgcaggcg cgcccccacg accaccgaga gccactggac cgtctgctcc gccatcaccg 101760 ccaacacatc cagcacgcgc cccaggaagg cggcctcccg cgtcaaaacg caccggacgg 101820 cgtcgggatt gaagcgggcg agcagggccc cggtggccag gtacgtcatg cggccggcat 101880 agcgggcggc cacgcgacag tcgcggtcca gcagcgcgcg caccccgggc cagtacagca 101940 gggaccccag cgagctgcga aacaccgcgg cgtcggggcc ggattggggg gacactaacc 102000 cccccgcgct cagtaacggc acggccgcgg ccccgacggg acgcaacgcc gtgaggctcg 102060 cgaactgccg cctcagctcg gcagccctgt cgtccaggtc cgacccgcgc gcctctgcgt 102120 gaaggcgcgt cccgcacacc cacccgttga tggccagccg cacgacggca tccgccaaaa 102180 agctcatcgc ctgggcgggg ctggtttttg ttcgacgatc cgtcaggtca agaatcccat 102240 cgcccgtgat ataccaggcc aacgcctcgc cctgctgcag ggtttggcgg aaaaacaccg 102300 cggggttgtc gggggaggcg aagtgcatga cccccacgcg cgataacccg aacgcgctat 102360 ccggacacgg gtaaaacccg gccggatgcc ccagggctag ggcggagcgc acggactcgt 102420 cccacacggc aacctgaggg gccagtcgat ccaacgggaa tgccgcccgg agctccgggc 102480 ccggcacgcg tccctccaga acctccacct tgggcgggga acgggccccg ccgccgtcct 102540 ccggcccgac gtcttccggg tagtcgtcct cctcgtactg cagttcctct aggaacagcg 102600 gcgacggcgc cacccgcgaa ccgccgaccc gccccaaaat agcccgcgcg tcgacgggac 102660 ccaggtatcc cccctgccgg gcctgcggag gaccgcgggg aacctcatca tcatcgtcca 102720 ggcgaccgcg caccgactgg ctacgggccg catcgggccc ggggcgctgc cgggacgctc 102780 ggcgatggga tgagggcggg gcttccgacg cgcgccgtcg tcgggctcgc gggccttccc 102840 gtcgacggcg cacgggcggc tcgtcgcccg ccatctcctc cagagcctct agctcgctgt 102900 cgtcatcccc gcggaacacc gcacgcaggt accccatgaa ccccacccca tcgcccgctg 102960 gctcgtccgc cacgggcgag gcgcgggggc gggtggatgc gcgcctcctg cgccccgcgg 103020 gttcgcgagc cgacatggtg gcgatagacg cgggttatcg gatgtccgct accccccaaa 103080 aaagaaaaag accccacagc gcggatggag gtcggggtag gtgccgccgg accccctcgc 103140 gatgggaatg gacgggagcg acggggccgg cgcaaaaaac gcagtatctc ccgcgaaggc 103200 tacccgccgc cccagccccc ggccaaatgc ggaaacggtc ccgcgctctc gcctttatac 103260 gcgggccgcc ctgcgacaca atcacccgtc cgtggtttcg aatctacacg acaggcccgc 103320 agacgcggct aacacacacg ccggcaaccc agaccccagt gggttggttg cgcggtcccg 103380 tctcctggct agttctttcc cccaccacca aataatcaga cgacaaccgc aggtttttgt 103440 aatgtatgtg ctcgtgttta ttgtggatac gaaccgggga cgggagggga aaacccagac 103500 gggggatgcg ggtccggtcg cgccccctac ccaccgtact cgtcaattcc aagggcatcg 103560 gtaaacatct gctcaaactc gaagtcggcc atatccagag cgccgtaggg ggcggagtcg 103620 tggggggtaa atcccggacc cggggaatcc ccgtccccca acatgtccag atcgaaatcg 103680 tctagcgcgt cggcatgcgc catcgccacg tcctcgccgt ctaagtggag ctcgtccccc 103740 aggctgacat cggtcggggg ggccgtcgac agtctgcgcg tgtgtcccgc ggggagaaag 103800 gacaggcgcg gagccgccag ccccgcctct tcgggggcgt cgtcgtccgg gagatcgagc 103860 aggccctcga tggtagaccc gtaattgttt ttcgtacgcg cgcggctgta cgcgtgttcc 103920 cgcatgaccg cctcggaggg cgaggtcgtg aagctggaat acgagtccaa cttcgcccga 103980 atcaacacca taaagtaccc agaggcgcgg gcctggttgc catgcagggt gggaggggtc 104040 gtcaacggcg cccctggctc ctccgtagcc gcgctgcgca ccagcgggag gttaaggtgc 104100 tcgcgaatgt ggtttagctc ccgcagccgg cgggcctcga ttggcactcc ccggacggtg 104160 agcgctccgt tgacgaacat gaagggctgg aacagacccg ccaactgacg ccagctctcc 104220 aggtcgcaac agaggcagtc aaacaggtcg ggccgcatca tctgctcggc gtacgcggcc 104280 cataggatct cgcgggtcaa aaatagatac aaatgcaaaa acagaacacg cgccagacga 104340 gcggtctctc ggtagtacct gtccgcgatc gtggcgcgca gcatttctcc caggtcgcga 104400 tcgcgtccgc gcatgtgcgc ctggcggtgc agctgccgga cgctggcgcg caggtaccgg 104460 tacagggccg agcagaagtt ggccaacacg gttcgatagc tctcctcccg cgcccgtagc 104520 tcggcgtgga agaaacgaga gagcgcttcg tagtagagcc cgaggccgtc gcgggtggcc 104580 ggaagcgtcg ggaaggccac gtcgccgtgg gcgcgaatgt cgatttgggc gcgttcgggg 104640 acgtacgcgt ccccccattc caccacatcg ctgggcagcg ttgataggaa tttacactcc 104700 cggtacaggt cggcgttggt cggtaacgcc gaaaacaaat cctcgttcca ggtatcgagc 104760 atggtacata gcgcggggcc cgcgctaaag cccaagtcgt cgaggagacg gttaaagagg 104820 gcggcggggg ggacgggcat gggcggggag ggcatgagct gggcctggct caggcgcccc 104880 gttgcgtaca gcggaggggc cgccggggtg tttttgggac ccccggccgg gcgggggggt 104940 ggtggcgaag cgccgtccgc gtccatgtcg gcaaacagct cgtcgaccaa gaggtccatt 105000 gggtggggtt gatacgggaa agacgatatc gggcttttga tgcgatcgtc cccgcccgcc 105060 cagagagtgt gggacgcccg acggcgcggg aagagaaaaa cccccaaacg cgttagagga 105120 ccggacggac cttatggggg gaagtgggca gcgggaaccc cgtccgttcc cgaggaatga 105180 cagcccgtgg tcgccacccc gcatttaagc aacccgcacg ggccgccccg tacctcgtga 105240 cttcccccca cattggctcc tgtcacgtga aggcaaaccg agggcggctg tccaacccac 105300 cccccgccac ccagtcacgg tccccgtcgg attgggaaac aaaggcacgc aacgccaaca 105360 ccgaatgaac ccctgttggt gctttattgt ctgggtacgg aagtttttca ctcgacgggc 105420 cgtctggggc gagaagcgga gcgggctggg gctcgaggtc gctcggtggg gcgcgacgcc 105480 gcagaacgcc ctcgagtcgc cgtggccgcg tcgacgtcct gcaccacgtc tggattcacc 105540 aactcgttgg cgcgctgaat caggtttttg ccctcgcaga ccgtcacgcg gatggtggtg 105600 atgccaagga gttcgttgag gtcttcgtct gtgcgcggac gcgacatgtc ccagagctgg 105660 accgccgcca tccgggcatg catggccgcc aggcgcccaa ccgcggcgca gaagacgcgc 105720 ttgttaaagc cggccacccg gggggtccat ggcgcgtcgg ggtttggggg ggcggtgcta 105780 aagtgcagct ttctggccag cccctgcgcg ggtgtcttgg atcgggttgg cgccgtcgac 105840 gcgggggcgt ctgggagtgc ggcggattct ggctgggccg atttcctgcc gcgggtggtc 105900 tccgccgccg gggccgcggg ggccttagtc gccacccgct gggttcgggg ggcccggggg 105960 gcggtggtgg gtgtgcgtcc ggcccctccg gacccagcgg gcggcggagg cgcccgcgca 106020 ggccccgggg cggacaaaac cgccccggaa acgggacgcc gcgtccgggg gacctccggg 106080 tgttcgtcgt cttcggatga cgagcccccg tagagggcat aatccgactc gtcgtactgg 106140 acgaaacgga cctcgcccct tgggcgcgcg cgtgtctgta gggcgccacg gcgggaggtg 106200 tcaggcggac tatcgggact cgccatacat gaagacgggg tgtagtacag atcctcgtac 106260 tcatcgcgcg gaacctcccg cggacccgac ttcacggagc ggcgagaggt catggttcca 106320 cgaacacgct agggtcggat gcgcggacaa ttaggcctgg gttcggacgg cgggggtggt 106380 gcaggtgtgg agaggtcgag cgataggggc ggcccgggag agaagagagg gtccgcaaaa 106440 cccactgggg atgcgtgagt ggccctctgt gggcggtggg ggagagtctt ataggaagtg 106500 catataacca caacccatgg gtctaaccaa tccccagggg ccaagaaaca gacacgcccc 106560 aaacggtctc ggtttccgcg aggaagggga agtcctggga caccctccac ccccacccct 106620 caccccacac agggcgggtt caggcgtgcc cggcagccag tagcctctgg cagatctgac 106680 agacgtgtgc gataatacac acgcccatcg aggccatgcc tacataaaag ggcaccaggg 106740 cccccggggc agacatttgg ccagcgtttt gggtctcgca ccgcgcgccc ccgatcccat 106800 cgcgcccgcc ctcctcgccg ggcggctccc cgtgcgggcc cgcgtctccc gccgctaagg 106860 cgacgagcaa gacaaacaac aggcccgccc gacagaccct tctggggggg cccatcgtcc 106920 ctaacaggaa gatgagtcag tggggatccg gggcgatcct tgtccagccg gacagcttgg 106980 gtcgggggta cgatggcgac tggcacacgg ccgtcgctac tcgcgggggc ggagtcgtgc 107040 aactgaacct ggtcaacagg cgcgcggtgg cttttatgcc gaaggtcagc ggggactccg 107100 gatgggccgt cgggcgcgtc tctctggacc tgcgaatggc tatgccggct gacttttgtg 107160 cgattattca cgcccccgcg ctatccagcc cagggcacca cgtaatactg ggtcttatcg 107220 actcggggta ccgcggaacc gttatggccg tggtcgtagc gcctaaaagg acgcgggaat 107280 ttgcccccgg gaccctgcgg gtcgacgtga cgttcctgga catcctggcg acccccccgg 107340 ccctcaccga gccgatttcc ctgcggcagt tcccgcaact ggcgcccccc cctccaaccg 107400 gggccgggat acgcgcagat ccttggttgg agggggcgct cggggaccca agcgtgactc 107460 ctgccctacc ggcgcgacgc cgagggcggt ccctcgtcta tgccggcgag ctgacgccgg 107520 ttcagacgga acacggggac ggcgtacgag aagccatcgc cttccttcca aaacgcgagg 107580 aggatgccgg tttcgacatt gtcgtccgtc gcccggtcac cgtcccggca aacggcacca 107640 cggtcgtgca gccatccctc cgcatgctcc acgcggacgc cgggcccgcg gcctgctatg 107700 tgctggggcg gtcgtcgctc aacgcccgcg gcctcctggt cgttcctacg cgctggctcc 107760 ccgggcacgt atgtgcgttt gttgtttaca accttacggg ggttcctgtg accctcgagg 107820 ccggcgccaa ggtcgcccag ctcctggttg cgggggcgga cgctcttcct tggatccccc 107880 cggacaactt tcacgggacc aaagcgcttc gaaactaccc caggggtgtt ccggactcaa 107940 ccgccgaacc caggaacccg ccgctcctgg tgtttacgaa cgagtttgac gcggaggccc 108000 ccccgagcga gcgcgggacc gggggttttg gctctaccgg tatttagccc atagcttggg 108060 gttcgttccg ggcaataaaa aacgtttgta tctcatcttt cctgtgtgta gttgtttctg 108120 ttggatgcct gtgggtctat cacacccgcc cctccatccc acaaacacag aacacacggg 108180 ttggatgaaa acacgcattt attgacccaa aacacacgga gctgctcgag atgggccagg 108240 gcgaggtgcg gttggggagg ctgtaggtct gggaacggac acgcggggac acgattccgg 108300 tttggggtcc gggagggcgt cgccgtttcg ggcggcaggc gccagcgtaa cctccggggg 108360 cggcgtgtgg gggtgcccca aggagggcgc ctcggtcacc ccaagccccc ccgagcgggt 108420 tcccccggca accccgaagg cggagaggcc aagggcccgt tcggcgatgg ccacatcctc 108480 catgaccacg tcgctctcgg ccatgctccg aatagcctgg gagacgagca catccgcgga 108540 cttgtcagcc gcccccacgg acatgtacat ctgcaggatg gtggccatac acgtgtccgc 108600 caggcgccgc atcttgtcct gatgggccgc cacggccccg tcgatcgtgg gggcctcgag 108660 cccggggtgg tggcgcgcca gtcgttctag gttcaccatg caggcgtggt acgtgcgggc 108720 caaggcgcgg gccttcacga ggcgtcgggt gtcgtccagg gaccccaggg cgtcatcgag 108780 cgtgatgggg gcgggaagta gcgcgttaac gaccaccagg gcctcctgca gccgcggctc 108840 cgcctccgag ggcggaacgg ccgcgcggat catctcatat tgttcctcgg ggcgcgctcc 108900 ccagccacat atagccccga gaagagaagc catcgcgggc gggtactggc ccttgggcgc 108960 gcggacgcaa tggggcagga agacgggaac cgcggggaga ggcgggcggc cgggactccc 109020 gtggaggtga ccgcgcttta tgcgaccgac gggtgcgtta ttacctcttc gatcgccctc 109080 ctcacaaact ctctactggg ggccgagccg gtttatatat tcagctacga cgcatacacg 109140 cacgatggcc gtgccgacgg gcccacggag caagacaggt tcgaagagag tcgggcgctc 109200 taccaagcgt cgggcgggct aaatggcgac tccttccgag taaccttttg tttattgggg 109260 acggaagtgg gtgggaccca ccaggcccgc gggcgaaccc gacccatgtt cgtctgtcgc 109320 ttcgagcgag cggacgacgt cgccgcgcta caggacgccc tggcgcacgg gaccccgcta 109380 caaccggacc acatcgccgc caccctggac gcggaggcca cgttcgcgct gcatgcgaac 109440 atgatcctgg ctctcaccgt ggccgtcaac aacgccagcc cccgcaccgg acgcgacgcc 109500 gccgcggcgc agtatgatca gggcgcgtcc ctacgctcgc tcgtggggcg cacgtccctg 109560 ggacaacgcg gccttaccac gctatacgtc caccacgagg cgcgcgtgct ggccgcgtac 109620 cgcagggcgt attatggaag cgcgcagagt cccttctggt ttcttagcaa attcgggcct 109680 gacgaaaaaa gcctggtgct caccactcgg tactacctgc ttcaggccca gcgtctgggg 109740 ggcgcggggg ccacgtacga cctgcaggcc atcaaggaca tctgcgccac ctacgcgatt 109800 ccccacgccc cccgccccga caccgtcagc gccgcgtccc tgacctcgtt tgccgccatc 109860 acgcggttct gttgcacgag ccagtacgcc cgcggggccg cggcggccgg gtttccgctt 109920 tacgtggagc gccgtattgc ggccgacgtc cgcgagacca gtgcgctgga gaagttcata 109980 acccacgatc gcagttgcct gcgcgtgtcc gaccgtgaat tcattacgta catttacctg 110040 gcccattttg agtgtttcag ccccccgcgc ctagccacgc atcttcgggc cgtgacgacc 110100 caggacccca accccgcggc caacacggag cagccctcgc ccctgggcag ggaggccgtg 110160 gaacaatttt tttgccacgt gcgcgcccaa ctgaatatcg gggagtacgt caaacacaac 110220 gtgacccccc gggagaccgt cctggatggc gatacggcca aggcctacct gcgcgctcgc 110280 acgtacgcgc ccggggccct gacgcccgcc cccgcgtatt gcggggccgt ggactccgcc 110340 accaaaatga tggggcgttt ggcggacgcc gaaaagctcc tggtcccccg cgggtggccc 110400 gcgtttgcgc ccgccagtcc cggggaggat acggcgggcg gcacgccgcc cccacagacc 110460 tgcggaatcg tcaagcgcct cctgagactg gccgccacgg aacaacagga caccacgccc 110520 ccggcgatcg cggcgcttat ccgtaatgcg gcggtgcaga ctcccctgcc cgtctaccgg 110580 atatccatgg tccccacggg acaggcattt gccgcgctgg cctgggacga ctgggcccgc 110640 ataacgcggg acgctcgcct ggccgaagcg gtcgtgtccg ccgaagcggc ggcgcacccc 110700 gaccacggcg cgctgggcag gcggctcacg gatcgcatcc gcgcccaggg ccccgtgatg 110760 ccccctggcg gcctggatgc cggggggcag atgtacgtga atcgcaacga gatatttaac 110820 ggcgcgctgg caatcacaaa catcatcctg gatctcgaca tcgccctgaa ggagcccgtc 110880 ccctttcgcc ggctccacga ggccctgggc cactttaggc gcggggctct ggcggcggtt 110940 cagctcctgt ttcccgcggc ccgcgtggac cccgacgcat atccctgtta ttttttcaaa 111000 agcgcatgtc ggcccggccc ggcgtccgtg ggttccggca gcggactcgg caacgacgac 111060 gacggggact ggtttccctg ctacgacgac gccggtgatg aggagtgggc ggaggacccg 111120 ggcgccatgg acacatccca cgatcccccg gacgacgagg ttgcctactt tgacctgtgc 111180 cacgaagtcg gccccacggc ggaacctcgc gaaacggatt cgcccgtgtg ttcctgcacc 111240 gacaagatcg gactgcgggt gtgcatgccc gtccccgccc cgtacgtcgt ccacggttct 111300 ctaacgatgc ggggggtggc acgggtcatc cagcaggcgg tgctgttgga ccgagatttt 111360 gtggaggcca tcgggagcta cgtaaaaaac ttcctgttga tcgatacggg ggtgtacgcc 111420 cacggccaca gcctgcgttt gccgtatttt gccaaaatcg cccccgacgg gcctgcgtgc 111480 ggaaggctgc tgccagtgtt tgtgatcccc cccgcctgca aagacgttcc ggcgtttgtc 111540 gccgcgcacg ccgacccgcg gcgcttccat tttcacgccc cgcccaccta tctcgcttcc 111600 ccccgggaga tccgtgtcct gcacagcctg ggtggggact atgtgagctt ctttgaaagg 111660 aaggcgtccc gcaacgcgct ggaacacttt gggcgacgcg agaccctgac ggaggtcctg 111720 ggtcggtaca acgtacagcc ggatgcgggg gggaccgtcg aggggttcgc atcggaactg 111780 ctggggcgga tagtcgcgtg catcgaaacc cactttcccg aacacgccgg cgaatatcag 111840 gccgtatccg tccggcgggc cgtcagtaag gacgactggg tcctcctaca gctagtcccc 111900 gttcgcggta ccctgcagca aagcctgtcg tgtctgcgct ttaagcacgg ccgggcgagt 111960 cgcgccacgg cgcggacatt cgtcgcgctg agcgtcgggg ccaacaaccg cctgtgcgtg 112020 tccttgtgtc agcagtgctt tgccgccaaa tgcgacagca accgcctgca cacgctgttt 112080 accattgacg ccggcacgcc atgctcgccg tccgttccct gcagcacctc tcaaccgtcg 112140 tcttgataac ggcgtacggc ctcgtgctcg tgtggtacac cgtcttcggt gccagtccgc 112200 tgcaccgatg tatttacgcg gtacgcccca ccggcaccaa caacgacacc gccctcgtgt 112260 ggatgaaaat gaaccagacc ctattgtttc tgggggcccc gacgcacccc cccaacgggg 112320 gctggcgcaa ccacgcccat atctgctacg ccaatcttat cgcgggtagg gtcgtgccct 112380 tccaggtccc acccgacgcc acgaatcgtc ggatcatgaa cgtccacgag gcagttaact 112440 gtctggagac cctatggtac acacgggtgc gtctggtggt cgtagggtgg ttcctgtatc 112500 tggcgttcgt cgccctccac caacgccgat gtatgtttgg tgtcgtgagt cccgcccaca 112560 agatggtggc cccggccacc tacctcttga actacgcagg ccgcatcgta tcgagcgtgt 112620 tcctgcagta cccctacacg aaaattaccc gcctgctctg cgagctgtcg gtccagcggc 112680 aaaacctggt tcagttgttt gagacggacc cggtcacctt cttgtaccac cgccccgcca 112740 tcggggtcat cgtaggctgc gagttgatgc tacgctttgt ggccgtgggt ctcatcgtcg 112800 gcaccgcttt catatcccgg ggggcatgtg cgatcacata ccccctgttt ctgaccatca 112860 ccacctggtg ttttgtctcc accatcggcc tgacagagct gtattgtatt ctgcggcggg 112920 gcccggcccc caagaacgca gacaaggccg ccgccccggg gcgatccaag gggctgtcgg 112980 gcgtctgcgg gcgctgttgt tccatcatcc tgtcgggcat cgcaatgcga ttgtgttata 113040 tcgccgtggt ggccggggtg gtgctcgtgg cgcttcacta cgagcaggag atccagaggc 113100 gcctgtttga tgtatgacgt cacatccagg ccggcggaaa ccggaacggc atatgcaaac 113160 tggaaactgt cctgtcttgg ggcccaccca cccgacgcgt catatgtaaa tgaaaatcgt 113220 tcccccgagg ccatgtgtag cctggatccc aacgaccccg cccatgggtc ccaattggcc 113280 gtcccgttac caagaccaac ccagccagcg tatccacccc cgcccgggtc cccgcggaag 113340 cggaacggtg tatgtgatat gctaattaaa tacatgccac gtacttatgg tgtctgattg 113400 gtccttgtct gtgccggagg tggggcgggg gccccgcccg gggggcggaa ctaggagggg 113460 tttgggagag ccggccccgg caccacgggt ataaggacat ccaccacccg gccggtggtg 113520 gtgtgcagcc gtgttccaac cacggtcacg cttcggtgcc tctccccgat tcgggcccgg 113580 tcgcttgcta ccggtgcgcc accaccagag gccatatccg acaccccagc cccgacggca 113640 gccgacagcc cggtcatggc gactgacatt gatatgctaa ttgacctcgg cctggacctc 113700 tccgacagcg atctggacga ggaccccccc gagccggcgg agagccgccg cgacgacctg 113760 gaatcggaca gcaacgggga gtgttcctcg tcggacgagg acatggaaga cccccacgga 113820 gaggacggac cggagccgat actcgacgcc gctcgcccgg cggtccgccc gtctcgtcca 113880 gaagaccccg gcgtacccag cacccagacg cctcgtccga cggagcggca gggccccaac 113940 gatcctcaac cagcgcccca cagtgtgtgg tcgcgcctcg gggcccggcg accgtcttgc 114000 tcccccgagc ggcacggggg caaggtggcc cgcctccaac ccccaccgac caaagcccag 114060 cctgcccgcg gcggacgccg tgggcgtcgc aggggtcggg gtcgcggtgg tcccggggcc 114120 gccgatggtt tgtcggaccc ccgccggcgt gcccccagaa ccaatcgcaa cccgggggga 114180 ccccgccccg gggcggggtg gacggacggc cccggcgccc cccatggcga ggcgtggcgc 114240 ggaagtgagc agcccgaccc acccggaggc ccgcggacac ggagcgtgcg ccaagcaccc 114300 cccccgctaa tgacgctggc gattgccccc ccgcccgcgg acccccgcgc cccggccccg 114360 gagcgaaagg cgcccgccgc cgacaccatc gacgccacca cgcggttggt cctgcgctcc 114420 atctccgagc gcgcggcggt cgaccgcatc agcgagagct tcggccgcag cgcacaggtc 114480 atgcacgacc cctttggggg gcagccgttt cccgccgcga atagcccctg ggccccggtg 114540 ctggcgggcc aaggagggcc ctttgacgcc gagaccagac gggtctcctg ggaaaccttg 114600 gtcgcccacg gcccgagcct ctatcgcact tttgccggca atcctcgggc cgcatcgacc 114660 gccaaggcca tgcgcgactg cgtgctgcgc caagaaaatt tcatcgaggc gctggcctcc 114720 gccgacgaga cgctggcgtg gtgcaagatg tgcatccacc acaacctgcc gctgcgcccc 114780 caggacccca ttatcgggac ggccgcggcg gtgctggata acctcgccac gcgcctgcgg 114840 ccctttctcc agtgctacct gaaggcgcga ggcctgtgcg gcctggacga actgtgttcg 114900 cggcggcgtc tggcggacat taaggacatt gcatccttcg tgtttgtcat tctggccagg 114960 ctcgccaacc gcgtcgagcg tggcgtcgcg gagatcgact acgcgaccct tggtgtcggg 115020 gtcggagaga agatgcattt ctacctcccc ggggcctgca tggcgggcct gatcgaaatc 115080 ctagacacgc accgccagga gtgttcgagt cgtgtctgcg agttgacggc cagtcacatc 115140 gtcgcccccc cgtacgtgca cggcaaatat ttttattgca actccctgtt ttaggtacaa 115200 taaaaacaaa acatttcaaa caaatcgccc cacgtgttgt ccttctttgc tcatggccgg 115260 cggggcgtgg gtcacggcag atggcggggg tgggcccggc gtacggcctg ggtgggcgga 115320 gggaactaac ccaacgtata aatccgtccc cgctccaagg ccggtgtcat agtgccctta 115380 ggagcttccc gcccgggcgc atcccccctt ttgcactatg acagcgaccc ccctcaccaa 115440 cctgttctta cgggccccgg acataaccca cgtggccccc ccttactgcc tcaacgccac 115500 ctggcaggcc gaaacggcca tgcacaccag caaaacggac tccgcttgcg tggccgtgcg 115560 gagttacctg gtccgcgcct cctgtgagac cagcggcaca atccactgct ttttctttgc 115620 ggtatacaag gacacccacc atacccctcc gctgattacc gagctccgca actttgcgga 115680 cctggttaac cacccgccgg tcctacgcga actggaggat aagcgcgggg tgcggctgcg 115740 gtgtgcgcgg ccgtttagcg tcgggacgat taaggacgtc tctgggtccg gcgcgtcctc 115800 ggcgggagag tacacgataa acgggatcgt gtaccactgc cactgtcggt atccgttctc 115860 aaaaacatgc tggatggggg cctccgcggc cctacagcac ctgcgctcca tcagctccag 115920 cggcatggcc gcccgcgcgg cagagcatcg acgcgtcaag attaaaatta aggcgtgatc 115980 tccaaccccc catgaatgtg tgtaaccccc cccaaaaaaa taaagagccg taacccaacc 116040 aaaccaggcg tggtgtgagt ttgtggaccc aaagccctca gagacaatgc gacaggccag 116100 tatggaccgt gatactttta tttattaact cacaggggcg cttaccgcca caggaatacc 116160 agaataatga ccaccacaat cgcgaccacc ccaaatacag catggcgcca caccacgcca 116220 caacagccct gtcgccggta tggggcatga tcagacgagc cgcgcgccgc gcgttgggcc 116280 ctgtacagct cgcgcgaatt gaccctagga ggccgccacg cgcccgagtt ttgcgttcgt 116340 cgctggtcgt cgggcgccaa agccccggac ggctgttcgg tcgaacgaac ggccacgaca 116400 gtggcatagg ttggggggtg gtccgacata gcctcggcgt acgtcgggag gcccgacaag 116460 aggtcccttg tgatgtcggg tggggccaca agcctggttt ccggaagaaa caggggggtt 116520 gccaataacc cgccagggcc aaaactccgg cgctgcgcac gtcgttcggc gcggcgccgg 116580 gcgcgccgag cggctcgctg ggcggcttgg cgtgagcggc cccgctccga cgcctcgccc 116640 tctccggagg aggttggcgg aattggcacg gacgacaggg gcccagcaga gtacggtgga 116700 ggtgggtccg tgggggtgtc cagatcaata acgacaaacg gcccctcgtt cctaccagac 116760 aagctatcgt aggggggcgg gggatcagca aacgcgttcc ccgcgctcca tagacccgcg 116820 tcgggttgcg ccgcctccga agccatggat gcgccccaaa gccacgactc ccgcgcgcta 116880 ggtccttggg gtaagggaaa aggccctact ccccatccaa gccagccaag ttaacgggct 116940 acgccttcgg ggatgggact ggcaccccgg cggattttgt tgggctggta cgcgtcgccc 117000 aaccgagggc cgcgtccacg ggacgcgcct tttataaccc cggggtcatt cccaacgatc 117060 acatgcaatc taactggctc ccctctcccc ccctctcccc tctccccccc tctcccctct 117120 ccccccctct cccctctccc cccctctccc ctctcccccc ctctcccctc tccccccctc 117180 tcccctctcc ccccctctcc cctctccccc cctctcccct ctccccccct ctcccctctc 117240 cccccctctc ccctgctctt tccccgtgac acccgacgct ggggggcgtg gctgccggga 117300 ggggccgcgt atgggcgggc ctactcggtc tcccgccccc ccgaaccgcc ccgccggctt 117360 tgcccccctt tgatcccctg ctacccccac cccgtgctcg tggtgcgggg tggggggatg 117420 tgggcggggg tgcgcgggag gtgtcggtgg tgggggtggt ggtggtggtg gtagtaggaa 117480 tggtggtggg ggggagggcg ctggttggtc aaaaaaggga gggacggggg ccggcagacc 117540 gacggcgaca acgctccccg gcggccgggt cgcggctctt acgagcggcc cggcccgcgc 117600 tcccaccccc cgggccgtgt ccttgctttc cccccgtctc cccccccgcc ttctcctcct 117660 cctcctcgtt tttccaaacc ccgcccaccc ggcccggccc ggcccggccc ggccaccgcc 117720 gcccacccac ccacctcggg atacccagcc ccggtccccc gttccccggg ggccgttatc 117780 tccagcgccc cgtccggcgc gccgcccccc gccgctaaac cccatcccgc ccccgggacc 117840 ccacatataa gcccccagcc acacgcaaga acagacacgc agaacggctg tgtttatttt 117900 aaataaaccg atgtcggaat aaacaaacac aaacacccgc gacgggggga cggaggggac 117960 ggagggaggg gggtgacggg ggacggaaac agacacaaaa aacaaccaca aaaaacaacc 118020 acccaccgac acccccaccc cagtctcctc gccttctccc acccacccca cgcccccact 118080 gagcccggtc gatcgacgag cacccccgcc cacgcccccg cccctgcccc ggcgaccccc 118140 ggcccgcacg atcccgacaa caataacaac cccaacggaa agcggcgggg tgttggggga 118200 ggcgaggaac aaccgagggg aacgggggat ggaaggacgg gaagtggaag tcctgatacc 118260 catcctacac ccccctgcct tccaccctcc ggccccccgc gagtccaccc gccggccggc 118320 taccgagacc gaacacggcg gccaccgccg ccgccgccgc cgacaccgca gagccggcgc 118380 gcgcacacac aagcggcaga ggcagaaagg ccccgagtca ttgtttatgt ggccgcgggc 118440 cagcagacgg cccgcgacac ccccccccgc ccgtgtgggt atccggcccc ccgccccgcg 118500 ccggtccatt aagggcgcgc gtgcccgcga gatatcaatc cgttaagtgc tctgcagaca 118560 ggggcaccgc gcccggaaat ccattaggcc gcagacgagg aaaataaaat tacatcacct 118620 acccatgtgg tgctgtggcc tgtttttgct gcgtcatctg agcctttata aaagcggggg 118680 cgcggccgtg ccgatcgccg gtggtgcgaa agactttccg ggcgcgtccg ggtgccgcgg 118740 ctctccgggc ccccctgcag ccggggcggc caaggggcgt cggcgacatc ctccccctaa 118800 gcgccggccg gccgctggtc tgttttttcg ttttccccgt ttcgggggtg gtgggggttg 118860 cggtttctgt ttctttaacc cgtctggggt gtttttcgtt ccgtcgccgg aatgtttcgt 118920 tcgtctgtcc cctcacgggg cgaaggccgc gtacggcccg ggacgagggg cccccgaccg 118980 cggcggtccg ggccccgtcc ggacccgctc gccggcacgc gacgcgaaaa aggccccccg 119040 gaggcttttc cgggttcccg gcccggggcc tgagatgaac actcggggtt accgccaacg 119100 gccggccccc gtggcggccc ggcccggggc cccggcggac ccaaggggcc ccggcccggg 119160 gccccacaac ggcccggcgc atgcgctgtg gttttttttt cctcggtgtt ctgccgggct 119220 ccgtcgcctt tcctgttctc gcttctcccc cccccccttc acccccagta ccctcctccc 119280 tcccttcctc ccccgttatc ccactcgtcg agggcgcccc ggtgtcgttc aacaaagacg 119340 ccgcgtttcc aggtaggtta gacacctgct tctccccaat agaggggggg ggacccaaac 119400 gacagggggc gccccagagg ctaaggtcgg ccacgccact cgcgggtggg ctcgtgttac 119460 agcacaccag cccgttattt tccccccctc ccacccttag ttagactctg ttacttaccc 119520 gtccgaccac caactgcccc cttatctaag ggccggctgg aagaccgcca gggggtcggc 119580 cggtgtcgct gtaacccccc acgccaatga cccacgtact ccaagaaggc atgtgtccca 119640 ccccgcctgt gtttttgtgc ctggctctct atgcttgggt cttactgcct gggggggggg 119700 agtgcggggg aggggggggg tgtggaagga aatgcacggc gcgtgtgtac ccccccctaa 119760 agttgttcct aaagcgagga tatggaggag tggcgggtgc cgggggaccg gggtgatctc 119820 tggcacgcgg gggtgggaag ggtcggggga gggggggatg gggtaccggc ccacctggcc 119880 ggcgcgggtg cgcgtgcctt tgcacaccaa ccccacgtcc cccggcggtc tctaagaaac 119940 accgcccccc ctccttcata ccaccgagca tgcctgggtg tgggttggta accaacacgc 120000 ccatcccctc gtctcctgtg attctctggc tgcaccgcat tcttgttttc taactatgtt 120060 cctgtttctg tctccccccc cacccctccg ccccaccccc caacacccac gtctgtggtg 120120 tggccgaccc ccttttgggc gccccgtccc gccccgctac ccctcccatc ctttgttgcc 120180 ctatagtgta gttaaccccc ccccccgccc tttgtggcgg ccagaggcca ggtcagtccg 120240 ggcgggcagg cgctcgcgga aacttaacac ccacacccaa cccactgtgg ttctggctcc 120300 atgccagtgg caggatgctt tcggggatcg gtggtcaggc agcccgggcc gcggctctgt 120360 ggttaacacc agagcctgcc caacatggca cccccactcc cacgcacccc cactcccacg 120420 cacccccact cccacgcacc cccactccca cgcaccccca ctcccacgca cccccactcc 120480 cacgcacccc cactcccacg cacccccact cccacgcacc cccactccca cgcacccccg 120540 cgatacatcc aacacagaca gggaaaagat acaaaagtaa acctttattt cccaacagac 120600 agcaaaaatc ccctgagttt tttttattag ggccaacaca aaagacccgc tggtgtgtgg 120660 tgcccgtgtc tttcactttc cacctccccg acacggattg gctggtgtag tgggcgcggc 120720 cagagaccac ccagcgcccg acccccccct ccccacaaac acgggggcgt cccttattgt 120780 tttccctcgt cccgggtcga cgccccctgc tccccggacc acgggtgccg agaccgcagg 120840 ctgcggaagt ccagggcgcc cactagggtg ccctggtcga acagcatgtt ccccacgggg 120900 gtcatccaga ggctgttcca ctccgacgcg ggggccgtcg ggtactcggg gggcgtcacg 120960 tggttacccg cggtctcggg gagcagggtg cggcggctcc agccggggac cgcggcccgc 121020 agccgggtcg ccatgtttcc cgtctggtcc accaggacca cgtacgcccc gatgttcccc 121080 gtctccatgt ccaggatggg caggcagtcc cccgtgatcg tcttgttcac gtaaggcgac 121140 agggcgacca cgctagagac ccccgagatg ggcaggtagc gcgtgaggcc gcccgcgggg 121200 acggccccgg aagtctccgc gtggcgcgtc ttccgggcac acttcctcgg cccccgcggc 121260 ccagaagcag cgcgggggcc gagggaggtt tcctcttgtc tccctcccag ggcaccgacg 121320 gccccgcccg aggaggcgga agcggaggag gacgcggccc cggtggcgga agaggtggcc 121380 cccgcgggag tcggggccga ggaggaagag gcggaggagg aagaggcgga ggccgccgag 121440 gacgtcaggg gggtcccggg ccctccctgg ccgcgccccc ccggccctga gtcggagggg 121500 gggtgcgtcg ccgccctctt ggcccctgcc ggcgcgaggg ggggacgcgt ggactggggg 121560 gaggggtttt cctggcccga cccgcgcctc ttcctcggac gcaccgccgc ctcctgctcg 121620 acagaggcgg cggaggggag cgggggggcg ccggaggggg cggcgccgga gggggcggcg 121680 ccgcgggagg gcccgtgtcc accctccacg cccggccccc ccgagccgcg cgccaccgtc 121740 gcacgcgccc ggcacagact ctgttcttgg ttcgcggcct gagccaggga cgagtgcgac 121800 tggggcacac ggcgcgcgtc cgcggggcgg gcggccggct ccgccccggg ggccggggcg 121860 cgggggccgg gccccggagg cggcgcccgc acacacgggg ccacggccgc gcgggggcgc 121920 gcggggcccg acgcggccgc ggacgcgggg ggaccggggc ggggggcgga gcctggcatg 121980 ggcgccgcgg ggggcctgtg gggagaggcc gggggggagt cgctgatcac tatggggtct 122040 ctgttgtttg caaggggggc gggtctgttg acaagggggc ccgtccggcc cctcggccgc 122100 cccgcctccg cttcaacaac cccaaccccc ccggaggggc cagacgcccc ccgcggcacc 122160 gcggctcgcg actggcggga gccgccgccg ccgctgctgt tggtggtggt gttagtgtta 122220 ctgctgccgt gtggcccgat gggcgccgag gggggcgctg tccgagccgc ggccggctgg 122280 ggggctgcgt gagacgcccc gcccgtcacg gggggcgcgg cggcgcctct gcgtgggggg 122340 gcgcggggcg tccggcgggg ggcgggcggt acgtagtctg ctgcaagaga caacgggggg 122400 cgcgatcagg ttacgccccc tccccggccc gccctttcct cgcccgcccg cccgcctatt 122460 cctccctccc ccccccctcc tcctcctccc ccagggtcct cgccgccccc ccgcctcacc 122520 gtcgtccagg tcgtcgtcat cctcgtccgt ggtgggctca gggtgggtgg gcgacagggc 122580 cctcaccgtg tgccccccca gggtcaggta ccgcggggcg aaccgctgat tgcccgtcca 122640 gataaagtcc acggccgtgc ccgccctgac ggcctcctcg gcctccatgc gggtctgggg 122700 gtcgttcacg atcgggatgg tgctgaacga cccgctgggc gtcacgccca ctatcaggta 122760 caccagcttg gcgttgcaca gcgggcaggt gttgcgcaat tgcatccagg ttttcatgca 122820 cgggatgcag aagcggtgca tgcacgggaa ggtgtcgcag cgcaggtggg gcgcgatctc 122880 atccgtgcac acggcgcaca cgtcgccctc gtcgctcccc ccgtcctctc gagggggggc 122940 gcccccgcaa ctgccggggt cttcctcgcg gggggggctc ccccccgaga ccgccccccc 123000 atccacgccc tgcggcccca gcagccccgt ctcgaacagt tccgtgtccg tgctgtccgc 123060 ctcggaggcg gagtcgtcgt catggtggtc ggcgtccccc cgccccccca cttcggtctc 123120 cgcctccgag tcgctgctgt ccggcaggtc tcggtcgcag ggaaacaccc agacatccgg 123180 ggcgggctga ggggaaaaaa gggggggcgg gtaagaatgg ggggatttcc cgcgtcaatc 123240 agcgcccacg agttccccct ccccccccgc ctcacaaagt cctgcccccc tgctggcctc 123300 ggaagagggg ggagaaaggg gtctgcaacc aaaggtggtc tgggtccgtc ctttggatcc 123360 cgacccctct tcttccctct tctcccgccc tccagacgca ccggagtcgg gggtcccacg 123420 gcgtccccca aatatggcgg gcggctcctc cccacccccc tagatgcgtg tgagtaaggg 123480 ggccctgcgt atgagtcagt ggggaccacg ccccctaaca cggcgacccc ggtccctgtg 123540 tgtttgttgt gggggcgtgt ctctgtgtat gagtcagggg ggtcccacgg cgaccccggg 123600 ccctgcgtct gagtcaaagg ggccatgtgt aggtgttggg ggtctgtata tataaagtca 123660 gggggtcaca tggcgacccc taacagggcg accccggtcc ctgtatatat agggtcaggg 123720 ggttccgcgc cccctaacat ggcgcccccg gtccctgtat atatagtgtc acggggttcc 123780 acgcccccta acatggcgcc ccaacatggc gcccggctcc cgtgtatgag tgggggtccc 123840 ccaacatggc ggccggttcc agtgtaaggg tcgggggtcc cccaacatgg cgccccccaa 123900 catggcgccc cccaacatgg cgccccagac atggcgcccg gcccctcacc tcgcgctggg 123960 ggcggccctc aggccggcgg gtactcgctc cggggcgggg ctccatgggg gtcgtatgcg 124020 gctggagggt cgctgacgga gggtccctgg gggtcgcaac gtaggcgggg cttctgtggt 124080 gatgcggaga gggggcggcc cgagtctgcc tggctgctgc gtctcgctcc gagtgccgag 124140 gtgcaaatgc gaccagaccg tcgggccagg gctaacttat accccacgcc tttcccctcc 124200 ccaaaggggc ggcagtgacg attcccccaa tggccgcgcg tcccagggga ggcaggccca 124260 ccgcggggcg gccccgtccc cggggaccaa cccggcgccc ccaaagaata tcattagcat 124320 gcacggcccg gcccccgatt tgggggacca acccggtgtc ccccaaagaa ccccattagc 124380 atgcccctcc cgccgacgca acaggggctt ggcctgcgtc ggtgccccgg ggcttcccgc 124440 cttcccgaag aaactcatta ccatacccgg aaccccaggg gaccaatgcg ggttcattga 124500 gcgacccgcg ggccaatgcg cgaggggccg tgtgttccgc caaaaaagca attaacataa 124560 cccggaaccc caggggagtg gttacgcgcg gcgcgggagg cggggaatac cggggttgcc 124620 cattaagggc cgcgggaatt gccggaagcg ggaagggcgg ccggggccgc ccattaatga 124680 gtttctaatt accataccgg gaagcggaac aaggcctctg caagttttta attaccatac 124740 cgggaagtgg gcggcccggc ccactgggcg ggagttaccg cccagtgggc cgggccccga 124800 cgactcggcg gacgctggtt ggccgggccc cgccgcgctg gcggccgccg attggccagt 124860 cccgccctcc gagggcgggc ccgcctcggg ggcgggccgg ctccaagcgt atatatgcgc 124920 ggctcctgcc atcgtctctc cggagagcgg cttggtgcgg agctcccggg agctccgcgg 124980 aagacccagg ccgcctcggg tgtaacgtta gaccgagttc gccgggccgg ctccgcgggc 125040 cagggcccgg gcacgggcct cgggccccag gcacggcccg atgaccgcct cggcctccgc 125100 cacccggcgc cggaaccgag cccggtcggc ccgctcgcgg gcccacgagc cgcggcgcgc 125160 caggcgggcg gccgaggccc agaccaccag gtggcgcacc cggacgtggg gcgagaagcg 125220 cacccgcgtg ggggtcgcgg gggtcgcggg ggtcgcgggg ggcttcggcg ccccctcccc 125280 gcccgcgcgt cgcaggcgca ggcgcgccag gtgctctgcg gtgacgcgca ggcggagggc 125340 gaggcgcggc ggaaggcgga aggggcgtga gggggggtgg gaggggttag ccccgccccc 125400 cgggcccgcg ccgggcggtg gggaccgggg gcggggggcg gcggcggtgg gccgggcctc 125460 tggcgccggc tcgggcgggg ggctgtccgg ccagtcgtcg tcgtcgtcgt cggacgcgga 125520 ctcgggaacg tggagccact ggcgcagcag cagcgaacaa gaaggcgggg gcccactggc 125580 ggggggcggc ggcggggcgg ccgcgggcgc gctcctgacc acgggttccg agttgggcgt 125640 ggaggttacc tgggactgtg cggttgggac cgcgcccgtg ggcccgggcg gccgggggcg 125700 gcgggggccg cgatggcggc ggcgggccat ggagacagag agcgtgccgg ggtggtagag 125760 tttgacaggc aagcatgtgc gtgcagaggc gagtagtgct tgcctgtcta actcgctagt 125820 ctcggccgcg gggggcccgg gctgcccgcc gcccgccttt aaagggccgc gcgcgacccc 125880 cggggggtgt gttttggggg gggcccgttt ccggggtctg gccgctcctc ccccgctcct 125940 ccccccgctc ctccccccgc tcctcccccc gctcctcccc ccgctcctcc ccccgctcct 126000 ccccccgctc ctccccccgc tcctcccccc gctcctcccc ccgctcctcc ccccgctcct 126060 ccccccgctc ctccccccgc tcctcccccc gctcctcccc ccgctcctcc ccccgctcct 126120 cccccgctcc tcccccgctc ccgcggcccc gccccccacg cccgccgcgc gcgcgcacgc 126180 cgcccggacc gccgcccgcc ttttttgcgc gcgcgcgcgc ccgcgggggg cccgggctgc 126240 cacaggtaaa acaacaccaa caaagcacgg cgcaatccgc acgtcacacg tcacgtcatc 126300 caccacacct gcccaacaac acaactcaca gcgacaactc accgcgcaac aactcctgtt 126360 cctcatccac acgtcaccgc gcacctcccg ctcctccaga cgtaccccgg cgcaacacac 126420 cgctcctgct acacaccacc gcccctcccc agccccagcc ctccccagcc ccagccctcc 126480 ccggccccag ccctccccgg ccccagccct ccccggcccc agccctcccc ggccccagcc 126540 ctccccggcc ccagccctcc ccagccccag ccctccccag ccgcgtcccg cgctccctcg 126600 ggggggttcg ggcatctcta cctcagtgcc gccaatctca ggtcagagat ccaaaccctc 126660 cgggggcgcc cgcgcaccac caccgcccct cgccccctcc cgcccctcgc cccctcccgc 126720 ccctcgcccc ctcccgcccc tcgccccctc ccgcccctcg ccccctcccg cccctcgccc 126780 cctcccgccc ctcgccccct cccgcccctc gccccctccc gcccctcgcc ccctcccgcc 126840 cctcgccccc tcccgcccct cgccccctcc cgcccctcgc cccctcccgc ccctcgcccc 126900 ctcccgcccc tcgccccctc ccgcccctcg ccccctcccg cccctcgccc cctcccgccc 126960 ctcgccccct cccgcccctc gccccctccc gcccctcgcc ccctcccgcc cctcgaataa 127020 acaacgctac tgcaaaactt aatcaggtcg ttgccgttta ttgcgtcttc gggtttcaca 127080 agcgccccgc cccgtcccgg cccgttacag caccccgtcc ccctcgaacg cgccgccgtc 127140 gtcttcgtcc caggcgcctt cccagtccac aacgtcccgt cgcgggggcg tggccaagcc 127200 cgcctccgcc cccagcacct ccacggcccc cgccgccgcc agcacggtgc cgctgcggcc 127260 cgtggccgag gcccagcgaa tcccgggcgg cgccggcggc agggcccccg ggccgtcgtc 127320 gtcgtcgccg cgcagcacca gcgggggggc gtcgtcgtcg ggctccagca gggcgcgggc 127380 gcaaaagtcc ctccgcggcc cgcgccaccg ggccgggccg gcgcgcaccg cctcgcgccc 127440 cagcgccacg tacacgggcc gcagcggcgc gcccaggccc cagcgcgcgc aggcgcggtg 127500 cgagtgggcc tcctcctcgc agaagtccgg cgcgccgggc gccatggcgt cggtggtccc 127560 cgaggccgcc gcccggccgt ccagcgccgg cagcacggcc cggcggtact cgcgcgggga 127620 catgggcacc ggcgtgtccg ggccgaagcg cgtgcgcacg cggtagcgca cgttgccgcc 127680 gcggcacagg cgcagcggcg gcgcgtcggg gtacaggcgc gcgtgcgcgg cctccacgcg 127740 cgcgaagacc cccgggccga acacgcggcc cgaggccagc accgtgcggc gcaggtcccg 127800 cgccgccggc cagcgcacgg cgcactgcac ggcgggcagc aggtcgcacg ccaggtaggc 127860 gtgctgccgc gacaccgcgg gcccgtcggc gggccagtcg caggcgcgca cggtgttgac 127920 cacgatgagc cgccggtcgc cggcgctggc gagcagcccc agaaactcca cggccccggc 127980 gaaggccagg tcccgcgtgg acagcagcag cacgccctgc gcgcccagcg ccgacacgtc 128040 gggggcgccg gtccagttgc ccgcccaggc ggccgtgtcc ggcccgcaca gccggttggc 128100 cagggccgcc agcaggcagg acagcccgcc gcgctcggcg gaccactccg gcggcccccc 128160 cgaggccccg ccgccggcca ggtcctcgcc cggcagcggc gagtacagca ccaccacgcg 128220 cacgtcctcg gggtcgggga tctggcgcat ccaggccgcc atgcggcgca gcgggcccga 128280 ggcgcgcagg gggccaaaga ggcggccccc ggcggccccg tgggggtggg ggttctcgtc 128340 gtcgtcgccg ccgcacgcgg cctgggcggc gggggcgggc ccggcgcacc gcgcggcgat 128400 cgaggccagg gcccgcgggt caaacatgag ggccggtcgc caggggacgg ggaacagcgg 128460 gtggtccgtg agctcggcca cggcgcgcgg ggagcagtag gcctccaggg cggcggccgc 128520 gggcgccgcc gtgtggctgg gcccccgggg ctgccgccgc cagccgccca gggggtcggg 128580 gccctcggcg ggccggcgcg acagcgccac ggggcgcggg cgggcctgcg ccgcggcgcc 128640 ccgggccgcc gcgggctggg cgggggtggg ctcgggcccc gggggcgtgg aggggggcgc 128700 ggggaggggg gcgcgggcgt ccgagccggg ggcgtccgcg ccgctcttct tcgtcttcgg 128760 gggtcgcggg ccgccgcctc cgggcggccg ggccgggccg ggactcttgc gcttgcgccc 128820 ctcccgcggc gcggcggagg cggcggcggc cgccagcgcg tcggcggcgt ccggtgcgct 128880 ggccgccgcc gccagcaggg ggcggaggct ctggttctca aacagcaggt ccgcggcggc 128940 ggcggccgcg gagctcggca ggcgcgggtc ccgcggcagc gcggggccca gggccccggc 129000 gaccaggctc acggcgcgca cggcggccac ggcggcctcg ctgccgccgg ccacgcgcag 129060 gtccccgcgc aggcgcatga gcaccagcgc gtcgcgcacg aaccgcagct cgcgcagcca 129120 cgcgcgcagg cggggcgcgt cggcgtgcgg cggcggcggg gaagcggggc ccgcgggtcc 129180 ctccggccgc ggggggctgg cgggccgggc cccggccagc cccgggacgg ccgccaggtc 129240 gccgtcgaag ccctcggcca gcgcctccag gatcccgcgg caggcggcca ggcactcgac 129300 ggccacgcgg ccggcctggg cgcggcgccc ggcgtcggcg tcggcgtggc gggcggcgtc 129360 ggggtcgtcg ccccccacgg gggaggcggg cgcggcggac agccgcccca gggcggcgag 129420 gatccccgcg gcgccgtacc cggcgggcac cgcgcgctcg cccggtgcgg cggcggcgac 129480 ggcggcgacc ccctcgtcat ctgcgccggc gccggggctc cccgcggccc ccgtcagcgc 129540 cgcgttctcg cgcgccaaca ggggcgcgta ggcgcggcgc aggctggtca gcaggaagcc 129600 cttctgcgcg cggtcgtatc ggcggctcat ggccacggcg gccgccgcgt gcgccaggcc 129660 ccagccgaag cggccggccg ccatggcgta gcccaggtgg ggcacggccc gcgccacgct 129720 gccggtgatg aaggagctgc tgttgcgcgc ggcgcccgag atccggaagc aggcctggtc 129780 cagcgccacg tccccgggga ccacgcgcgg gttctggagc caccccatgg cctccgcgtc 129840 cggggtgtac agcagccgcg tgatcagggc gtactgctgc gcggcgtcgc ccagctcggg 129900 cgcccacacg gccgccgggg cgcccgaggc ctcgaaccgg cgtcgcgcct cctccgcctc 129960 gggcgccccc cagaggcccg ggcggctgtc gcccaggccg ccgtacagca cccgccccgg 130020 gggcgggggc ccggcgccgg gccacggctc cccgctgacg tacccgtcgc gatagcgcgc 130080 gtagaaggcg ccggaggccg cgtcggcgtc cagctcgacc cgccggggct gcccggccgt 130140 gaagcggccc gtggcgtcgc ggccggccac cgccgcgcgg gcccggcggc gctcgatgcg 130200 gcccgcggag gccgcggggg tcctcgccgc cgcccggggc ttgggcgcgg cctcggagag 130260 ggggggtggc ccgggcgggg gcggcgtccg cccgggggct tccggcgccg cgctcgacgg 130320 accccgcccg acggcccgcg cctcgcgtgc gtggtcggcc gcgtcgttgc cgtcgtcgtc 130380 ctcgtcctcg tcggacgacg aggacgaaga ggatgcggac gacgaggacg aggacccgga 130440 gtccgacgag gtcgatgacg ccgatggccg ccgccggccg tgacgacgtc tccgcggcgg 130500 ctgggccggc gggcgcggcg acaggcggtc cgtggggtcc ggatacgcgc cgcgtagcgg 130560 ggcctcccgt tcgcggcccc gggccggggc ccggtcgccg gcggcgtcgg ctgcgtcgtc 130620 gtactcgtcc ccgtcatcgt cgtcggctag aaaggcgggg gtccggggcg gcgaggccgc 130680 ggggtcgggc gtcgggatcg tccggacggc ctcctctacc atggaggcca gcagagccag 130740 ctgtcgcgac gagacggcgt ccccggcgtc ctcgccggcg tcggtgcccg ccgcgggggc 130800 cctcccgtcc cgccgggcgt cgtcgaggtc gtgggggtgg tcggggtcgt ggtcggggtc 130860 gtccccgccc tcctccgtct ccgcgcccca cccgagggcc ccccgctcgt cgcggtctgg 130920 gctcggggtg ggcggcggcc cgtcggtggg gcccggggag ccggggcgct gcttgttctc 130980 cgacgccatc gccgatgcgg ggcgatcctc cggggatacg gctgcgacgg cggacgtagc 131040 acggtaggtc acctacggac tctcgatggg gggagggggc gagacccacg gaccccgacg 131100 acccccgccg tcgacgcgga actagcgcgg accggtcgat gcttgggtgg ggaaaaagga 131160 cagggacggc cgatccccct cccgcgcttc gtccgcgtat cggcgtcccg gcgcggcgag 131220 cgtctgacgg tctgtctctg gcggtcccgc gtcgggtcgt ggatccgtgt cggcagccgc 131280 gctccgtgtg gacgatcggg gcgtcctcgg gctcatatag tcccaggggc cggcgggaag 131340 gaggagcagc ggaggccgcc ggccccccgc cccccggcgg gcccaccccg aacggaattc 131400 cattatgcac gaccccgccc cgacgccggc acgccggggg cccgtggccg cggcccgttg 131460 gtcgaacccc cggccccgcc catccgcgcc atctgccatg gacggggcgc gagggcgggt 131520 gggtccgcgc cccgccccgc atggcatctc attaccgccc gatccggcgg tttccgcttc 131580 cgttccgcat gctaacgagg aacgggcagg gggcggggcc cgggccccga cttcccggtt 131640 cggcggtaat gagatacgag ccccgcgcgc ccgttggccg tccccgggcc cccggtcccg 131700 cccgccggac gccgggacca acgggacggc gggcggccct tgggccgccc gccttgccgc 131760 ccccccattg gccggcgggc gggaccgccc caagggggcg gggccgccgg gtaaaagaag 131820 tgagaacgcg aagcgttcgc acttcgtccc aatatatata tattattagg gcgaagtgcg 131880 agcactggcg ccgtgcccga ctccgcgccg gccccggggg cggacccggg cggcgggggg 131940 cgggtctctc cggcgcacat aaaggcccgg cgcgaccgac gcccgcagac ggcgccagcc 132000 acgaacgacg ggagcggctg cggagcacgc ggaccgggag cgggagtcgc agagggccgt 132060 cggagcggac ggcgtcggca tcgcgacgcc ccggctcggg atcgggatcg catcggaaag 132120 ggacacgcgg acgcgggggg gaaagacccg cccaccccac ccacgaaaca caggggacgc 132180 accccggggg cctccgacga cagaaaccca ccggtccgcc ttttttgcac gggtaagcac 132240 cttgggtggg cagaggaggg gggacgcggg ggcggaggag gggggacgcg ggggcggagg 132300 aggggggacg cgggggcgga ggagggggga cgcgggggcg gaggaggggg gacgcggggg 132360 cggaggaggg ggctcacccg cgttcgtgcc ttcccgcagg aggaacgccc tcgtcgaggc 132420 gaccggcggc gaccgttgcg tggaccgctt cctgctcgtc gggggggggg gagccactgt 132480 ggtcctccgg gacgttttct ggatggccga catttcccca ggcgcttttg tgccttgtgt 132540 aaaagcgcgg cgtcccgctc tccgatcccc gcccctgggc acgcgcaagc gcaagcgccc 132600 tgcccgcccc ctctcatcgg agtctgaggt cgaatccgag acagccttgg agtctgaggt 132660 cgaatccgag acagcatcgg attcgaccga gtctggggac caggaggaag ccccccgcat 132720 cggtggccgt agggcccccc ggaggcttgg ggggcggttt tttctggaca tgtcggcgga 132780 atccaccacg gggacggaaa cggatgcgtc ggtgtcggac gaccccgacg acacgtccga 132840 ctggtcttgt gacgacattc ccccacgacc caagcgggcc cgggtaaacc tgcggctcac 132900 tagctctccc gatcggcggg atggggttat ttttcctaag atggggcggg tccggtctac 132960 ccgggaaacg cagccccggg cccccacccc gtcggcccca agcccaaatg caatgctccg 133020 gcgctcggtg cgccaggccc agaggcggag cagcgcacga tggacccccg acctgggcta 133080 catgcgccag tgtatcaatc agctgtttcg ggtcctgcgg gtcgcccggg acccccacgg 133140 cagtgccaac cgcctgcgcc acctgatacg cgactgttac ctgatgggat actgccgagc 133200 ccgtctggcc ccgcgcacgt ggtgccgctt gctgcaggtg tccggcggaa cctggggcat 133260 gcacctgcgc aacaccatac gggaggtgga ggctcgattc gacgccaccg cagaacccgt 133320 gtgcaagctt ccttgtttgg aggccagacg gtacggcccg gagtgtgatc ttagtaatct 133380 cgagattcat ctcagcgcga caagcgatga tgaaatctcc gatgccaccg atctggaggc 133440 cgccggttcg gaccacacgc tcgcgtccca gtccgacacg gaggatgccc cctcccccgt 133500 tacgctggaa accccagaac cccgcgggtc cctcgctgtg cgtctggagg atgagtttgg 133560 ggagtttgac tggacccccc aggagggctc ccagccctgg ctgtctgcgg tcgtggccga 133620 taccagctcc gtggaacgcc cgggcccatc cgattctggg gcgggtcgcg cagcagaaga 133680 ccgcaagtgt ctggacggct gccggaaaat gcgcttctcc accgcctgcc cctatccgtg 133740 cagcgacacg tttctccggc cgtgagtccg gtcgccccga cccccttgta tgtccccaaa 133800 ataaaagacc aaaatcaaag cgtttgtccc agcgtcttaa tggcgggaag ggcggagaga 133860 aacagaccac gcgtacatgg ggggtgtttg ggggtttatt gacatcgggg ctacagggtg 133920 gtaaccggat agcagatgtg aggaagtctg ggccgttcgc cgcgaacggc gatcagaggg 133980 tccgtttctt gcggaccacg gcccggtgat gtgggttgct cgtctaaaat ctcgggcata 134040 cccatacacg cacaacacgg acgccgcacc gaatgggacg tcgtaagggg gtgggaggta 134100 gctgggtggg gtttgtgcag agcaatcagg gaccgcagcc agcgcataca atcgcgctcc 134160 cgtccgttgg tcccgggcag gaccacgccg tactggtatt cgtaccggct gagcagggtc 134220 tccagggggt ggttgggtgc cgcggggaac ggggtccacg ccacggtcca ctcgggcaaa 134280 aaccgagtcg gcacggccca cggttctccc acccacgcgt ctggggtctt gatggcgata 134340 aatcttaccc cgagccggat tttttgggcg tattcgagaa acggcacaca cagatccgcc 134400 gcgcctacca cccacaagtg gtagaggcga ggggggctgg gttggtctcg gtgcaacagt 134460 cggaagcacg ccacggcgtc cacgacctcg gtgctctcca aggggctgtc ctccgcaaac 134520 aggcccgtgg tggtgtttgg ggggcagcga caggacctag tgcgcacgat cgggcgggtg 134580 ggtttgggta agtccatcag cggctcggcc aaccgtcgaa ggttggccgg gcgaacgacg 134640 accggggtac ccaggggttc tgatgccaaa atgcggcact gcctaagcag gaagctccac 134700 agggccgggc ttgcgtcgac ggaagtccgg ggcagggcgt tgttctggtc aaggagggtc 134760 attacgttga cgacaacaac gcccatgttg gtatattaca ggcccgtgtc cggtttgggg 134820 cacttgcaga tttgtaaggc cacgcacggc ggggagacag gccgacgcgg gggctgctct 134880 aaaaatttaa gggccctacg gtccacagac ccgccttccc gggggggccc ttggagcgac 134940 cggcagcgga ggcgtccggg ggaggggagg gttatttacg ggggggtagg tcagggggtg 135000 ggtcgtcaaa ctgccgctcc ttaaaacccc ggggcccgtc gttcggggtg ctcgttggtt 135060 ggcactcacg gtgcggcgaa tggcctgtcg taagttttgt cgcgtttacg ggggacaggg 135120 caggaggaag gaggaggccg tcccgccgga gacaaagccg tcccgggtgt ttcctcatgg 135180 ccccttttat accccagccg aggacgcgtg cctggactcc ccgcccccgg agacccccaa 135240 accttcccac accacaccac ccggcgatgc cgagcgcctg tgtcatctgc aggagatcct 135300 ggcccagatg tacggaaacc aggactaccc catagaggac gaccccagcg cggatgccgc 135360 ggacgatgtc gacgaggacg ccccggacga cgtggcctat ccggaggaat acgcagagga 135420 gctttttctg cccggggacg cgaccggtcc ccttatcggg gccaacgacc acatccctcc 135480 cccgcgtggc gcatctcccc ccggtatacg acgacgcagc cgggatgaga ttggggccac 135540 gggatttacc gcagaagagc tggacgccat ggacaggcag gcggctcgag ccatcagccg 135600 cggcggcaag cccccctcga ccatggccaa gctggtgact ggcatgggct ttacgatcca 135660 cggagcgctc accccaggat cggaggggtg tgtctttgac agcagccacc cagattaccc 135720 ccaacgggta atcgtgaagg cggggtggta cacgagcacg agccacgagg cgcgactgct 135780 gaggcgactg gaccacccgg cgatcctgcc cctcctggac ctgcatgtcg tctccggggt 135840 cacgtgtctg gtcctcccca agtaccaggc cgacctgtat acctatctga gtaggcgcct 135900 gaacccactg ggacgcccgc agatcgcagc ggtctcccgg cagctcctaa gcgccgttga 135960 ctacattcac cgccagggca ttatccaccg cgacattaag accgaaaata tttttattaa 136020 cacccccgag gacatttgcc tgggggactt tggtgccgcg tgcttcgtgc agggttcccg 136080 atcaagcccc ttcccctacg gaatcgccgg aaccatcgac accaacgccc ccgaggtcct 136140 ggccggggat ccgtatacca cgaccgtcga catttggagc gccggtctgg tgatcttcga 136200 gactgccgtc cacaacgcgt ccttgttctc ggccccccgc ggccccaaaa ggggcccgtg 136260 cgacagtcag atcacccgca tcatccgaca ggcccaggtc cacgttgacg agttttcccc 136320 gcatccagaa tcgcgcctca cctcgcgcta ccgctcccgc gcggccggga acaatcgccc 136380 gccttacacc cgaccggcct ggacccgcta ctacaagatg gacatagacg tcgaatatct 136440 ggtttgcaaa gccctcacct tcgacggcgc gcttcgcccc agcgccgcag agctgctttg 136500 tttgccgctg tttcaacaga aatgaccgcc cccggggggc ggtgctgttt gcgggttggc 136560 acaaaaagac cccgacccgc gtctgtggtg tttttggcat catgtcgccg ggcgccatgc 136620 gtgccgttgt tcccattatc ccattccttt tggttcttgt cggtgtatcg ggggttccca 136680 ccaacgtctc ctccaccacc caaccccaac tccagaccac cggtcgtccc tcgcatgaag 136740 cccccaacat gacccagacc ggcaccaccg actctcccac cgccatcagc cttaccacgc 136800 ccgaccacac accccccatg ccaagtatcg gactggagga ggaggaggaa gaggaggagg 136860 gggccgggga tggcgaacat cttaaggggg gagatgggac ccgtgacacc ctaccccagt 136920 ccccgggtcc agccgtcccg ttggccgggg atgacgagaa ggacaaaccc aaccgtcccg 136980 tagtcccacc ccccggtccc aacaactccc ccgcgcgccc cgagaccagt cgaccgaaga 137040 caccccccac cagtatcggg ccgctggcaa ctcgacccac gacccaactc ccctcaaagg 137100 ggcgaccctt ggttccgacg cctcaacata ccccgctgtt ctcgttcctc actgcctccc 137160 ccgccctgga caccctcttc gtcgtcagca ccgtcatcca caccttatcg tttgtgtgta 137220 ttgttgctat ggcgacacac ctgtgtggtg gttggtccag acgcgggcga cgcacacacc 137280 ctagcgtgcg ttacgtgtgc ctgccgcccg aacgcgggta gggtatgggg cggggatggg 137340 gagagcccac acgcggaaag caagaacaat aaaggcggcg ggatctagtt gatatgcgtc 137400 tctgggtgtt tttggggtgt ggtgggcgcg gggcggtcat tggacggggg tgcagttaaa 137460 tacatgcccg ggacccatga agcatgcgcg acttccgggc ctcggaaccc acccgaaacg 137520 gccaacggac gtctgagcca ggcctggcta tccggagaaa cagcacacga cttggcgttc 137580 tgtgtgtcgc gatgtctctg cgcgcagtct ggcatctggg gcttttggga agcctcgtgg 137640 gggctgttct tgccgccacc catctgggac ctgcggccaa cacaacggac cccttaacgc 137700 acgccccagt gtcccctcac cccagccccc tggggggctt tgccgtcccc ctcgtagtcg 137760 gtgggctgtg tgccgtagtc ctgggggcgg cgtgtctgct tgagctcctg cgtcgtacgt 137820 gccgcgggtg ggggcgttac catccctaca tggacccagt tgtcgtataa ttttttcccc 137880 cccccccttc tccgcatggg tgatgtcggg tccaaactcc cgacaccacc agctggcatg 137940 gtataaatca ccggtgcgcc ccccaaacca tgtccggcag ggggatgggg ggcgaatgcg 138000 gagggcaccc aacaacaccg ggctaaccag gaaatccgtg gccccggccc ccaacaaaga 138060 tcgcggtagc ccggccgtgt gacattatcg tccataccga ccacaccgac gaatccccta 138120 agggggaggg gccattttac gaggaggagg ggtataacaa agtctgtctt taaaaagcag 138180 gggttaggga gttgttcggt cataagcttc agtgcgaacg accaactacc ccgatcatca 138240 gttatcctta aggtctcttt tgtgtggtgc gttccggtat ggggggggct gccgccaggt 138300 tgggggccgt gattttgttt gtcgtcatag tgggcctcca tggggtccgc ggcaaatatg 138360 ccttggcgga tgcctctctc aagatggccg accccaatcg ctttcgcggc aaagaccttc 138420 cggtcctgga ccagctgacc gaccctccgg gggtccggcg cgtgtaccac atccaggcgg 138480 gcctaccgga cccgttccag ccccccagcc tcccgatcac ggtttactac gccgtgttgg 138540 agcgcgcctg ccgcagcgtg ctcctaaacg caccgtcgga ggccccccag attgtccgcg 138600 gggcctccga agacgtccgg aaacaaccct acaacctgac catcgcttgg tttcggatgg 138660 gaggcaactg tgctatcccc atcacggtca tggagtacac cgaatgctcc tacaacaagt 138720 ctctgggggc ctgtcccatc cgaacgcagc cccgctggaa ctactatgac agcttcagcg 138780 ccgtcagcga ggataacctg gggttcctga tgcacgcccc cgcgtttgag accgccggca 138840 cgtacctgcg gctcgtgaag ataaacgact ggacggagat tacacagttt atcctggagc 138900 accgagccaa gggctcctgt aagtacgccc tcccgctgcg catccccccg tcagcctgcc 138960 tctcccccca ggcctaccag cagggggtga cggtggacag catcgggatg ctgccccgct 139020 tcatccccga gaaccagcgc accgtcgccg tatacagctt gaagatcgcc gggtggcacg 139080 ggcccaaggc cccatacacg agcaccctgc tgcccccgga gctgtccgag acccccaacg 139140 ccacgcagcc agaactcgcc ccggaagacc ccgaggattc ggccctcttg gaggaccccg 139200 tggggacggt ggcgccgcaa atcccaccaa actggcacat cccgtcgatc caggacgccg 139260 cgacgcctta ccatcccccg gccaccccga acaacatggg cctgatcgcc ggcgcggtgg 139320 gcggcagtct cctggcagcc ctggtcattt gcggaattgt gtactggatg caccgccgca 139380 ctcggaaagc cccaaagcgc atacgcctcc cccacatccg ggaagacgac cagccgtcct 139440 cgcaccagcc cttgttttac tagatacccc cccttaatgg gtgcgggggg gtcaggtctg 139500 cggggttggg atgggacctt aactccatat aaagcgagtc tggaaggggg gaaaggcgga 139560 cagtcgataa gtcggtagcg ggggacgcgc acctgttccg cctgtcgcac ccacagcttt 139620 ttcgcgaacc gtcccgtttc gggatgccgt gccgcccgtt gcagggcctg gtgctcgtgg 139680 gcctctgggt ctgtgccacc agcctggttg tccgtggccc cacggtcagt ctggtatcaa 139740 actcatttgt ggacgccggg gccttggggc ccgacggcgt agtggaggaa gacctgctta 139800 ttctcgggga gcttcgcttt gtgggggacc aggtccccca caccacctac tacgatgggg 139860 tcgtagagct gtggcactac cccatgggac acaaatgccc acgggtcgtg catgtcgtca 139920 cggtgaccgc gtgcccacgt cgccccgccg tggcatttgc cctgtgtcgc gcgaccgaca 139980 gcactcacag ccccgcatat cccaccctgg agctgaatct ggcccaacag ccgcttttgc 140040 gggtccggag ggcgacgcgt gactatgccg gggtgtacgt gttacgcgta tgggtcgggg 140100 acgcaccaaa cgccagcctg tttgtcctgg ggatggccat agccgccgaa ggtactctgg 140160 cgtacaacgg ctcggcccat ggctcctgcg acccgaaact gcttccgtct tcggccccgc 140220 gtctggcccc ggcgagcgta taccaacccg cccctaaccc ggcctccacc ccctcgacca 140280 ccacctccac cccctcgacc accatccccg ctccccaagc atcgaccaca cccttcccca 140340 cgggagaccc aaaaccccaa cctcacgggg tcaaccacga acccccatcg aatgccacgc 140400 gagcgacccg cgactcgcga tatgcgctaa cggtgaccca gataatccag atagccatcc 140460 ccgcgtccat tatagccctg gtgtttctgg ggagctgtat ttgctttata cacagatgtc 140520 aacgccgcta ccgacgctcc cgccgcccga tttacagccc ccagataccc acgggcatct 140580 catgcgcggt gaacgaagcg gccatggccc gcctcggagc cgagctcaaa tcgcatccga 140640 gcaccccccc caaatcccgg cgccggtcgt cacgcacgcc aatgccctcc ctgacggcca 140700 tcgccgaaga gtcggagccc gcgggggcgg ctgggcttcc gacgcccccc gtggacccca 140760 cgacatccac cccaacgcct cccctgttgg tataggtcca cggccactgg ccgggggcac 140820 cacataaccg accgcagtca ctgagttggg aataaaccgg tattatttac ctatatccgt 140880 gtatgtccat ttctttcttc cccccccccc ccggaaacca aagaaggaag caaagaatgg 140940 atgggaggag ttcaggaagc cggggagagg gcccgcggcg catttaaggc gttgttgtgt 141000 tgactttggc tcttctggcg ggttggtgcg gtgctgtttg ttgggctccc attttacccg 141060 aagatcggct gctatccccg ggacatggat cgcggggcgg tggtggggtt tcttctcggt 141120 gtttgtgttg tatcgtgctt ggcgggaacg cccaaaacgt cctggagacg ggtgagtgtc 141180 ggcgaggacg tttcgttgct tccagctccg gggcctacgg ggcgcggccc gacccagaaa 141240 ctactatggg ccgtggaacc cctggatggg tgcggcccct tacacccgtc gtgggtctcg 141300 ctgatgcccc ccaagcaggt gcccgagacg gtcgtggatg cggcgtgcat gcgcgctccg 141360 gtcccgctgg cgatggcgta cgcccccccg gccccatctg cgaccggggg tctacgaacg 141420 gacttcgtgt ggcaggagcg cgcggccgtg gttaaccgga gtctggttat tcacggggtc 141480 cgagagacgg acagcggcct gtataccctg tccgtgggcg acataaagga cccggctcgc 141540 caagtggcct cggtggtcct ggtggtgcaa ccggccccag ttccgacccc acccccgacc 141600 ccagccgatt acgacgagga tgacaatgac gagggcgagg acgaaagtct cgccggcact 141660 cccgccagcg ggaccccccg gctcccgcct ccccccgccc ccccgaggtc ttggcccagc 141720 gcccccgaag tctcacatgt gcgtggggtg accgtgcgta tggagactcc ggaagctatc 141780 ctgttttccc ccggggagac gttcagcacg aacgtctcca tccatgccat cgcccacgac 141840 gaccagacct actccatgga cgtcgtctgg ttgaggttcg acgtgccgac ctcgtgtgcc 141900 gagatgcgaa tatacgaatc gtgtctgtat cacccgcagc tcccagaatg tctgtccccg 141960 gccgacgcgc cgtgcgccgc gagtacgtgg acgtctcgcc tggccgtccg cagctacgcg 142020 gggtgttcca gaacaaaccc cccaccgcgc tgttcggccg aggctcacat ggagcccgtc 142080 ccggggctgg cgtggcaggc ggcctccgtc aatctggagt tccgggacgc gtccccacaa 142140 cactccggcc tgtatctgtg tgtggtgtac gtcaacgacc atattcacgc ctggggccac 142200 attaccatca gcaccgcggc gcagtaccgg aacgcggtgg tggaacagcc cctcccacag 142260 cgcggcgcgg atttggccga gcccacccac ccgcacgtcg gggcccctcc ccacgcgccc 142320 ccaacccacg gcgccctgcg gttaggggcg gtgatggggg ccgccctgct gctgtctgcg 142380 ctggggttgt cggtgtgggc gtgtatgacc tgttggcgca ggcgtgcctg gcgggcggtt 142440 aaaagcaggg cctcgggtaa ggggcccacg tacattcgcg tggccgacag cgagctgtac 142500 gcggactgga gctcggacag cgagggagaa cgcgaccagg tcccgtggct ggcccccccg 142560 gagagacccg actctccctc caccaatgga tccggctttg agatcttatc accaacggct 142620 ccgtctgtat acccccgtag cgacgggcat caatctcgcc gccagctcac aacctttgga 142680 tccggaaggc ccgatcgccg ttactcccag gcctccgatt cgtccgtctt ctggtaaggc 142740 gccccatccc gaggccccac gtcggtcgcc gaactgggcg accgccggcg aggtggacgt 142800 cggagacgag ctaatcgcga tttccgacga acgcggaccc ccccgacatg accgcccgcc 142860 cctcgccacg tcgaccgcgc cctcgccaca cccgcgaccc ccgggctaca cggccgttgt 142920 ctccccgatg gccctccagg ctgtcgacgc cccctccctg tttgtcgcct ggctggccgc 142980 tcggtggctc cggggggctt ccggcctggg ggccgtcctg tgtgggattg cgtggtatgt 143040 gacgtcaatt gcccgaggcg cacaaagggc cggtggtccg cctagccgca gcaaattaaa 143100 aatcgtgagt cacagcgacc gcaacttccc acccggagct ttcttccggc ctcgatgacg 143160 tcccggctct ccgatcccaa ctcctcagcg cgatccgaca tgtccgtgcc gctttatccc 143220 acggcctcgc cagtttcggt cgaagcctac tactcggaaa gcgaagacga ggcggccaac 143280 gacttcctcg tacgcatggg ccgccaacag tcggtattaa ggcgttgacg cagacgcacc 143340 cgctgcgtcg gcatggtgat cgcctgtctc ctcgtggccg ttctgtcggg cggatttggg 143400 gcgctcctga tgtggctgct ccgctaaaag accgcatcga cacgcgcgtc cttcttgtcg 143460 tctctcttcc cccccatcac cccgcaattt gcacccagcc tttaactaca ttaaattggg 143520 ttcgattggc aatgttgtct cccggttgat ttttgggtgg gtggggagtg ggtgggtggg 143580 gagtgggtgg gtggggagtg ggtgggtggg gagtgggtgg gtggggagtg ggtgggtggg 143640 gagtgggtgg gtggggagtg ggtgggtggg gagtgggtgg gtggggagtg ggtgggtggg 143700 gagtggcaag gaagaaacaa gcccgaccac cagacagaaa atgtaaccat acccaaaccg 143760 actctggggg ctgtttgtgg ggtcggaacc ataggatgaa caaaccaccc cgtacctccc 143820 gcacccaagg gtgcgggtgg ctcatcggca tctgtccggt atgggttgtt ccccacccac 143880 tcgcgttcgg acgtcttaga atcatggcgg ttttctatgc cgacatcggt tttctccccc 143940 gcaataagac acgatgcgat aaaatctgtt tgtaaaattt attaagggta caaattgccc 144000 tagcacaggg gtggggttag ggccgggtcc ccacacccaa acgcaccaaa cagatgcagg 144060 cagtgggtcg agtacagccc cgcgtacgaa cacgtcgatg cgtgtgtcag acagcaccag 144120 aaagcacagg ccatcaacag gtcgtgcatg tgtcggtggg tttggacgcg gggggccatg 144180 gtggtgataa agttaatggc cgccgtccgc cagggccaca ggggcgacgt ctcttggttg 144240 gcccggagcc actgggtgtg gaccagccgc gcgtggcggc ccaacatggc ccctgtagcc 144300 gggggcgggg gatcgcgcac gtttgcagcg cacatgcgag acacctcgac cacggttcga 144360 aagaaggccc ggtggtccgc gggcaacatc accaggtgcg caagcgcccg ggcgtccaga 144420 gggtagagcc ctgagtcatc cgaggttggc tcatcgcccg ggtcttgccg caagtgcgtg 144480 tgggttgggc ttccggtggg cgggacgcga accgcggtgt ggatcccgac gcgggcccga 144540 gcgtatgctc catcttgtgg ggagaagggg tctgggctcg ccaggggggc atacttgccc 144600 gggctataca gacccgcgag ccgtacgtgg ttcgcggggg gtgcgtgggg tccggggctc 144660 cctgggagac cggggttgtc gtggatccct ggggtcacgc ggtaccctgg ggtctctggg 144720 agctcgcggt actctgggtt ccctaggttc tcggggtggt cgcggaaccc ggggctcccg 144780 gggaacacgc ggtgtcctgg ggattgttgg cggtcggacg gcttcagatg gcttcgagat 144840 cgtagtgtcc gcaccgactc gtagtagacc cgaatctcca cattgccccg ccgcttgatc 144900 attatcaccc cgttgcgggg gtccggagat catgcgcggg tgtcctcgag gtgcgtgaac 144960 acctctgggg tgcatgccgg cggacggcac gccttttaag taaacatctg ggtcgcccgg 145020 cccaactggg gccgggggtt gggtctggct catctcgaga gacacggggg ggaaccaccc 145080 tccgcccaga gactcgggtg atggtcgtac ccgggactca acgggttacc ggattacggg 145140 gactgtcggt cacggtcccg ccggttcttc gatgtgccac acccaaggat gcgttggggg 145200 cgatttcggg cagcagcccg ggagagcgca gcaggggacg ctccgggtcg tgcacggcgg 145260 ttctggccgc ctcccggtcc tcacgccccc ttttattgat ctcatcgcgt acgtcggcgt 145320 acgtcctggg cccaacccgc atgttgtcca ggaaggtgtc cgccatttcc agggcccacg 145380 acatgctttt ccccccgacg agcaggaagc ggtccacgca acggtcgccg ccggtcgcct 145440 cgacgagggc gttcctcctg cgggaaggca cgaacgcggg tgagccccct cctccgcccc 145500 cgcgtccccc ctcctccgcc cccgcgtccc ccctcctccg cccccgcgtc ccccctcctc 145560 cgcccccgcg tcccccctcc tccgcccccg cgtcccccct cctctgccca cccaaggtgc 145620 ttacccgtgc aaaaaaggcg gaccggtggg tttctgtcgt cggaggcccc cggggtgcgt 145680 cccctgtgtt tcgtgggtgg ggtgggcggg tctttccccc ccgcgtccgc gtgtcccttt 145740 ccgatgcgat cccgatcccg agccggggcg tcgcgatgcc gacgccgtcc gctccgacgg 145800 ccctctgcga ctcccgctcc cggtccgcgt gctccgcagc cgctcccgtc gttcgtggct 145860 ggcgccgtct gcgggcgtcg gtcgcgccgg gcctttatgt gcgccggaga gacccgcccc 145920 ccgccgcccg ggtccgcccc cggggccggc gcggagtcgg gcacggcgcc agtgctcgca 145980 cttcgcccta ataatatata tatattggga cgaagtgcga acgcttcgcg ttctcacttc 146040 ttttacccgg cggccccgcc cccttggggc ggtcccgccc gccggccaat gggggggcgg 146100 caaggcgggc ggcccaaggg ccgcccgccg tcccgttggt cccggcgtcc ggcgggcggg 146160 accgggggcc cggggacggc caacgggcgc gcggggctcg tatctcatta ccgccgaacc 146220 gggaagtcgg ggcccgggcc ccgccccctg cccgttcctc gttagcatgc ggaacggaag 146280 cggaaaccgc cggatcgggc ggtaatgaga tgccatgcgg ggcggggcgc ggacccaccc 146340 gccctcgcgc cccgtccatg gcagatggcg cggatgggcg gggccggggg ttcgaccaac 146400 gggccgcggc cacgggcccc cggcgtgccg gcgtcggggc ggggtcgtgc ataatggaat 146460 tccgttcggg gtgggcccgc cggggggcgg ggggccggcg gcctccgctg ctcctccttc 146520 ccgccggccc ctgggactat atgagcccga ggacgccccg atcgtccaca cggagcgcgg 146580 ctgccgacac ggatccacga cccgacgcgg gaccgccaga gacagaccgt cagacgctcg 146640 ccgcgccggg acgccgatac gcggacgaag cgcgggaggg ggatcggccg tccctgtcct 146700 ttttccccac ccaagcatcg accggtccgc gctagttccg cgtcgacggc gggggtcgtc 146760 ggggtccgtg ggtctcgccc cctcccccca tcgagagtcc gtaggtgacc taccgtgcta 146820 cgtccgccgt cgcagccgta tccccggagg atcgccccgc atcggcgatg gcgtcggaga 146880 acaagcagcg ccccggctcc ccgggcccca ccgacgggcc gccgcccacc ccgagcccag 146940 accgcgacga gcggggggcc ctcgggtggg gcgcggagac ggaggagggc ggggacgacc 147000 ccgaccacga ccccgaccac ccccacgacc tcgacgacgc ccggcgggac gggagggccc 147060 ccgcggcggg caccgacgcc ggcgaggacg ccggggacgc cgtctcgtcg cgacagctgg 147120 ctctgctggc ctccatggta gaggaggccg tccggacgat cccgacgccc gaccccgcgg 147180 cctcgccgcc ccggaccccc gcctttctag ccgacgacga tgacggggac gagtacgacg 147240 acgcagccga cgccgccggc gaccgggccc cggcccgggg ccgcgaacgg gaggccccgc 147300 tacgcggcgc gtatccggac cccacggacc gcctgtcgcc gcgcccgccg gcccagccgc 147360 cgcggagacg tcgtcacggc cggcggcggc catcggcgtc atcgacctcg tcggactccg 147420 ggtcctcgtc ctcgtcgtcc gcatcctctt cgtcctcgtc gtccgacgag gacgaggacg 147480 acgacggcaa cgacgcggcc gaccacgcac gcgaggcgcg ggccgtcggg cggggtccgt 147540 cgagcgcggc gccggaagcc cccgggcgga cgccgccccc gcccgggcca ccccccctct 147600 ccgaggccgc gcccaagccc cgggcggcgg cgaggacccc cgcggcctcc gcgggccgca 147660 tcgagcgccg ccgggcccgc gcggcggtgg ccggccgcga cgccacgggc cgcttcacgg 147720 ccgggcagcc ccggcgggtc gagctggacg ccgacgcggc ctccggcgcc ttctacgcgc 147780 gctatcgcga cgggtacgtc agcggggagc cgtggcccgg cgccgggccc ccgcccccgg 147840 ggcgggtgct gtacggcggc ctgggcgaca gccgcccggg cctctggggg gcgcccgagg 147900 cggaggaggc gcgacgccgg ttcgaggcct cgggcgcccc ggcggccgtg tgggcgcccg 147960 agctgggcga cgccgcgcag cagtacgccc tgatcacgcg gctgctgtac accccggacg 148020 cggaggccat ggggtggctc cagaacccgc gcgtggtccc cggggacgtg gcgctggacc 148080 aggcctgctt ccggatctcg ggcgccgcgc gcaacagcag ctccttcatc accggcagcg 148140 tggcgcgggc cgtgccccac ctgggctacg ccatggcggc cggccgcttc ggctggggcc 148200 tggcgcacgc ggcggccgcc gtggccatga gccgccgata cgaccgcgcg cagaagggct 148260 tcctgctgac cagcctgcgc cgcgcctacg cgcccctgtt ggcgcgcgag aacgcggcgc 148320 tgacgggggc cgcggggagc cccggcgccg gcgcagatga cgagggggtc gccgccgtcg 148380 ccgccgccgc accgggcgag cgcgcggtgc ccgccgggta cggcgccgcg gggatcctcg 148440 ccgccctggg gcggctgtcc gccgcgcccg cctcccccgt ggggggcgac gaccccgacg 148500 ccgcccgcca cgccgacgcc gacgccgggc gccgcgccca ggccggccgc gtggccgtcg 148560 agtgcctggc cgcctgccgc gggatcctgg aggcgctggc cgagggcttc gacggcgacc 148620 tggcggccgt cccggggctg gccggggccc ggcccgccag ccccccgcgg ccggagggac 148680 ccgcgggccc cgcttccccg ccgccgccgc acgccgacgc gccccgcctg cgcgcgtggc 148740 tgcgcgagct gcggttcgtg cgcgacgcgc tggtgctcat gcgcctgcgc ggggacctgc 148800 gcgtggccgg cggcagcgag gccgccgtgg ccgccgtgcg cgccgtgagc ctggtcgccg 148860 gggccctggg ccccgcgctg ccgcgggacc cgcgcctgcc gagctccgcg gccgccgccg 148920 ccgcggacct gctgtttgag aaccagagcc tccgccccct gctggcggcg gcggccagcg 148980 caccggacgc cgccgacgcg ctggcggccg ccgccgcctc cgccgcgccg cgggaggggc 149040 gcaagcgcaa gagtcccggc ccggcccggc cgcccggagg cggcggcccg cgacccccga 149100 agacgaagaa gagcggcgcg gacgcccccg gctcggacgc ccgcgccccc ctccccgcgc 149160 ccccctccac gcccccgggg cccgagccca cccccgccca gcccgcggcg gcccggggcg 149220 ccgcggcgca ggcccgcccg cgccccgtgg cgctgtcgcg ccggcccgcc gagggccccg 149280 accccctggg cggctggcgg cggcagcccc gggggcccag ccacacggcg gcgcccgcgg 149340 ccgccgccct ggaggcctac tgctccccgc gcgccgtggc cgagctcacg gaccacccgc 149400 tgttccccgt cccctggcga ccggccctca tgtttgaccc gcgggccctg gcctcgatcg 149460 ccgcgcggtg cgccgggccc gcccccgccg cccaggccgc gtgcggcggc gacgacgacg 149520 agaaccccca cccccacggg gccgccgggg gccgcctctt tggccccctg cgcgcctcgg 149580 gcccgctgcg ccgcatggcg gcctggatgc gccagatccc cgaccccgag gacgtgcgcg 149640 tggtggtgct gtactcgccg ctgccgggcg aggacctggc cggcggcggg gcctcggggg 149700 ggccgccgga gtggtccgcc gagcgcggcg ggctgtcctg cctgctggcg gccctggcca 149760 accggctgtg cgggccggac acggccgcct gggcgggcaa ctggaccggc gcccccgacg 149820 tgtcggcgct gggcgcgcag ggcgtgctgc tgctgtccac gcgggacctg gccttcgccg 149880 gggccgtgga gtttctgggg ctgctcgcca gcgccggcga ccggcggctc atcgtggtca 149940 acaccgtgcg cgcctgcgac tggcccgccg acgggcccgc ggtgtcgcgg cagcacgcct 150000 acctggcgtg cgacctgctg cccgccgtgc agtgcgccgt gcgctggccg gcggcgcggg 150060 acctgcgccg cacggtgctg gcctcgggcc gcgtgttcgg cccgggggtc ttcgcgcgcg 150120 tggaggccgc gcacgcgcgc ctgtaccccg acgcgccgcc gctgcgcctg tgccgcggcg 150180 gcaacgtgcg ctaccgcgtg cgcacgcgct tcggcccgga cacgccggtg cccatgtccc 150240 cgcgcgagta ccgccgggcc gtgctgccgg cgctggacgg ccgggcggcg gcctcgggga 150300 ccaccgacgc catggcgccc ggcgcgccgg acttctgcga ggaggaggcc cactcgcacc 150360 gcgcctgcgc gcgctggggc ctgggcgcgc cgctgcggcc cgtgtacgtg gcgctggggc 150420 gcgaggcggt gcgcgccggc ccggcccggt ggcgcgggcc gcggagggac ttttgcgccc 150480 gcgccctgct ggagcccgac gacgacgccc ccccgctggt gctgcgcggc gacgacgacg 150540 acggcccggg ggccctgccg ccggcgccgc ccgggattcg ctgggcctcg gccacgggcc 150600 gcagcggcac cgtgctggcg gcggcggggg ccgtggaggt gctgggggcg gaggcgggct 150660 tggccacgcc cccgcgacgg gacgttgtgg actgggaagg cgcctgggac gaagacgacg 150720 gcggcgcgtt cgagggggac ggggtgctgt aacgggccgg gacggggcgg ggcgcttgtg 150780 aaacccgaag acgcaataaa cggcaacgac ctgattaagt tttgcagtag cgttgtttat 150840 tcgaggggcg ggagggggcg aggggcggga gggggcgagg ggcgggaggg ggcgaggggc 150900 gggagggggc gaggggcggg agggggcgag gggcgggagg gggcgagggg cgggaggggg 150960 cgaggggcgg gagggggcga ggggcgggag ggggcgaggg gcgggagggg gcgaggggcg 151020 ggagggggcg aggggcggga gggggcgagg ggcgggaggg ggcgaggggc gggagggggc 151080 gaggggcggg agggggcgag gggcgggagg gggcgagggg cgggaggggg cgaggggcgg 151140 gagggggcga ggggcgggag ggggcgaggg gcggtggtgg tgcgcgggcg cccccggagg 151200 gtttggatct ctgacctgag attggcggca ctgaggtaga gatgcccgaa cccccccgag 151260 ggagcgcggg acgcggctgg ggagggctgg ggctggggag ggctggggcc ggggagggct 151320 ggggccgggg agggctgggg ccggggaggg ctggggccgg ggagggctgg ggccggggag 151380 ggctggggct ggggagggct ggggctgggg aggggcggtg gtgtgtagca ggagcggtgt 151440 gttgcgccgg ggtacgtctg gaggagcggg aggtgcgcgg tgacgtgtgg atgaggaaca 151500 ggagttgttg cgcggtgagt tgtcgctgtg agttgtgttg ttgggcaggt gtggtggatg 151560 acgtgacgtg tgacgtgcgg attgcgccgt gctttgttgg tgttgtttta cctgtggcag 151620 cccgggcccc ccgcgggcgc gcgcgcgcgc aaaaaaggcg ggcggcggtc cgggcggcgt 151680 gcgcgcgcgc ggcgggcgtg gggggcgggg ccgcgggagc gggggaggag cgggggagga 151740 gcggggggag gagcgggggg aggagcgggg ggaggagcgg ggggaggagc ggggggagga 151800 gcggggggag gagcgggggg aggagcgggg ggaggagcgg ggggaggagc ggggggagga 151860 gcggggggag gagcgggggg aggagcgggg ggaggagcgg ggggaggagc ggggggagga 151920 gcgggggagg agcggccaga ccccggaaac gggccccccc caaaacacac cccccggggg 151980 tcgcgcgcgg ccctttaaag gcgggcggcg g 152011 <210> 2 <211> 35 <212> DNA <213> linker <400> 2 ggtggcggtg gcagcggggg agggggaagc ggtgg 35 <210> 3 <211> 53 <212> DNA <213> NcoI-gD-6B5 linker sense primer <400> 3 catgccatgg ggtccgcggc caggttactc tgaaagagtc tggccctggg ata 53 <210> 4 <211> 81 <212> DNA <213> NcoI-gD-6B5 linker antisense primer <400> 4 ccaccgcttc cccctccccc gctgccaccg ccacctttta tttccagctt ggtcccccct 60 ccgaacgtgt acggaacatg t 81 <210> 5 <211> 63 <212> DNA <213> Linker-gD-BssHII sense <400> 5 cagcggggga gggggaagcg gtggcggagg gagtgcaagt cacatccagg cgggcctacc 60 gga 63 <210> 6 <211> 39 <212> DNA <213> Linker-gD-BssHII antisense <400> 6 ttggcgcgct ccaacacggc gtagtaaacc gtgatcggg 39

Claims

HSV-1(Herpes Simplex Virus 1) 유래의 당단백질 D(glycoprotein D) 유전자 중 3' 말단 영역이 결실되고 일부 영역이 암 표적 서열로 치환된 뉴클레오티드를 포함하는 HSV-1 재조합을 위한 벡터로서, 상기 3' 말단 영역은 서열번호 1의 뉴클레오티드 서열 중 138,837 내지 139,463 번째 서열이고, 일부 영역은 서열번호 1의 뉴클레오티드 서열 중 138,353 내지 138,510 번째 서열이며 벡터는 셔틀 벡터인 것인 벡터.
삭제
삭제
청구항 1에 있어서, 상기 암 표적 서열로 치환된 일부 영역은 HVEM, 넥틴-1, 또는 3-OS-HS에 결합하여 HSV-1가 세포에 감염하도록 유도하는 역할을 수행하는 것인 벡터.
청구항 1에 있어서, 상기 암 표적 서열이 EGFRvⅢ(epidermal growth factor receptor variant Ⅲ), EGFR, FGFR, 인테그린(integrin), EpCAM, HMWMAA 수용체, CD40, PSMA, VEGFR2, Tie2, 엽산 수용체(Folate receptor), 난포자극호르몬수용체(follicle stimulating hormone recptor), 엽산(folic acid), 뉴로필린 수용체(neuropilin receptor), 및 트랜스페린 수용체(transferrin receptor)로 구성된 군으로부터 선택된 1종 이상에 결합하는 서열인 것인 벡터.
청구항 1에 있어서, 상기 암 표적 서열과 당단백질 D가 링커(linker)로 연결된 것인 벡터.
청구항 6에 있어서, 링커는 서열번호 2의 서열인 것인 벡터.
HSV-1 유래의 당단백질 D 유전자 중 3' 말단 영역이 결실되고, 일부 영역이 암 표적 서열로 치환된 뉴클레오티드를 포함하는 벡터를 제조하는 단계로서, 상기 3' 말단 영역은 서열번호 1의 뉴클레오티드 서열 중 138,837 내지 139,463 번째 서열이고, 일부 영역은 서열번호 1의 뉴클레오티드 서열 중 138,353내지 138,510 번째 서열이며 벡터는 셔틀 벡터인 것인 단계; 및
상기 벡터를 세포에 형질도입하여 재조합 HSV-1을 수득하는 단계를 포함하는 재조합 HSV-1을 제조하는 방법.
청구항 8에 있어서, 상기 재조합 HSV-1은 당단백질 D 유전자 영역이 재조합된 것으로, 상기 형질도입 시 암 표적 서열이 당단백질 D 유전자와 상동 재조합된 것인 방법.