WO1998020016A1 - Novel coding sequences from herpes simplex virus type-2 - Google Patents

Abstract

This invention relates to newly identified HSV-2 polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting or activating the biosynthesis or action of such polynucleotides or polypeptides and the use of such inhibitors or activators in therapy.

Description

NOVEL CODING SEQUENCES FROM HERPES SIMPLEX VIRUS TYPE-2 Field of the Invention:

This invention relates to newly identified Herpes Simplex Virus type 2 (HSV-2) polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy of viral infections or related diseases. Background of the Invention:

The herpes viruses consist of large icosahedral enveloped virions containing linear double stranded DNA genomes. Currently, eight human herpes viruses have been isolated and are known to be responsible for a variety of disease states, from sub-clinical infections to fatal disease in the immuno compromised. One human herpes virus, herpes simplex virus type 2, designated HSV-2, is usually acquired through sexual contact giving rise to the condition known as genital herpes. The frequency of recurrence of secondary genital herpes ranges between one and six times per year per infected individual. It is estimated that genital HSV-2 infections occur in ten to sixty million individuals in the USA. Less frequently, HSV-2 infection results in herpes labialis, seen as cold sores. General information about HSV-2 may be found in various treatises such as, Herpes

Simplex Viruses, In: "Field's Virology", 3rd ed., Lippincott-Raven Publ, pp2297-2342 (1996); Magder, L.S., et a New. England J. Med. 321 :7-12 (1989); and "The Human Herpes viruses", Roizman, B. et al., eds. Raven Press, New York, (1993), the contents of which are incorporated herein by reference for purposes of background. Currently, there are no vaccines available to protect against HSV-2 infection.

Individuals continue to become infected by the virus and no completely satisfactory antiviral agents or vaccines are available. Thus HSV-2 presents a major public health problem. There is a need for prophylactic and therapeutic vaccines as well as a method of identifying anti-HSV-2 agents and for reagents useful in such methods. There is a need for a method of identifying compounds which modulate the activity of HSV-2 polynucleotides and proteins and which affect the ability of the virus to replicate and produce multiple infectious virions in an infected cell. There is a need for methods of, and kits for, distinguishing HSV-2 infections from other herpes virus infections. Brief Description of the Invention:

Toward these ends, it is an object of the present invention to provide polypeptides, inter alia, that have been identified as novel HSV^ polypeptides by comparison between the amino acid sequences set out in Tables 1-4 and known amino acid sequences of proteins of other viruses such as herpes simplex virus type-1 (HSV-1).

It is a further object of the invention, to provide polynucleotides that encode HSV-2 proteins, particularly polynucleotides that encode the polypeptides encoded by the Open Reading Frames (ORFs) provided herein, or fragments, analogs or derivatives thereof.

In a particularly preferred embodiment of this aspect of the invention the polynucleotides comprise any of the regions encoding HSV-2 proteins in the sequences set out in Tables 1-4, including fragments, analogs or derivatives thereof.

In another particularly preferred embodiment of the present invention, there is a novel HSV-2 protein comprising any of the amino acid sequences shown in Table 1, or fragments, analogues or derivatives thereof. In accordance with the invention there is provided an isolated nucleic acid molecule encoding a polypeptide expressible by the HSV-2 polynucleotide contained in the deposited HSV-2 strain, SB5.

In accordance with the invention there are provided isolated nucleic acid molecules encoding HSV-2 proteins, nucleic acid molecules such as, mRNAs, cDNAs, genomic DNAs and, in further embodiments of this aspect of the invention, biologically, diagnostically, clinically or therapeutically useful variants, analogs or derivatives thereof, or fragments thereof, including fragments of the variants, analogs and derivatives.

Among the particularly preferred embodiments of this aspect of the invention are naturally occurring allelic variants of HSV-2 proteins. In accordance with this aspect of the invention there are provided novel polypeptides of

HSV-2 origin as well as biologically, diagnostically or therapeutically useful fragments thereof, as well as variants, derivatives and analogs of the foregoing and fragments thereof.

In accordance with certain preferred embodiments of this and other aspects of the invention there are probes that hybridize to HSV-2 sequences useful for detection of viral infection.

It also is an object of the invention to provide HSV-2 polypeptides or fragments thereof that may be employed for therapeutic or prophylactic purposes, for example, to treat disease, including treatment by conferring host immunity against viral infections, or as an antiviral agent or a vaccine. In accordance with another aspect of the present invention, there is provided the use of a polynucleotide of the invention for therapeutic or prophylactic purposes, in particular genetic immunization.

Among the particularly preferred embodiments of this aspect of the invention are variants of HSV-2 polypeptides encoded by naturally occurring alleles of HSV-2 genes for therapeutic or prophylactic use.

It is another object of the invention to provide a process for producing the aforementioned polypeptides, polypeptide fragments, variants and derivatives, fragments of the variants and derivatives, and analogs thereof. In a preferred embodiment of this aspect of the invention there are provided methods for producing the aforementioned HSV-2 polypeptides comprising culturing host cells having expressibly incorporated therein an exogenously-derived HSV-2 encoding polynucleotide under conditions for expression of HSV-2 in the host and then recovering the expressed polypeptide. In accordance with another object of the invention there are provided products, compositions, processes and methods that utilize the aforementioned polypeptides and polynucleotides, inter alia, for research, biological, clinical, diagnostic, prophylatic and therapeutic purposes.

In accordance with yet another aspect of the present invention, there are provided inhibitors of such polypeptides, useful as antiviral agents. In particular, there are provided antibodies against such polypeptides. In certain particularly preferred embodiments in this regard, die antibodies are selective for HSV-2.

In a further aspect of the invention there are provided compositions comprising a HSV-2 polynucleotide or HSV-2 polypeptide for administration to cells in vitro, to cells ex vivo and to cells in vivo, or to a multicellular organism. In certain preferred embodiments of this aspect of the invention, the compositions comprise a HSV-2 polynucleotide for expression of a HSV-2 polypeptide in a host organism to raise an immunological response, preferably to raise immunity in such host against HSV-2 or related organisms.

Other objects, features, advantages and aspects of the present invention will become apparent to those of skill from the following description. It should be understood, however, that the following description and the specific examples, while indicating preferred embodiments of the invention, are given by way of illustration only. Various changes and modifications within the spirit and scope of the disclosed invention will become readily apparent to those skilled in the art from reading the following description and from reading the other parts of the present disclosure. Detailed Description of the Invention:

Tables 1-3 show the nucleotide sequences of one strand of "contigs," prepared by assembling sequences derived by sequencing HSV-2, Strain SB5, DNA. Collectively, the contigs herein represent between 85% to over 90% of the genome of this organism. Each of Table 1, 2 and 3 represents a separate sequencing of the HSV-2, SB5, DNA.

Tables 1-3 also show the nucleotide sequences of open reading frames (ORFs), which are deduced DNA coding sequences present within each contig. Tables 1-4 also show the deduced amino acid sequences of polypeptides encoded by these ORFs and sequence homologies to proteins in the NCBI non-redundant protein database. Each ORF represents a HSV-2 gene although in some cases, a given ORF may actually have been derived from a gene that is longer than the ORF.

Each of the DNA sequences provided herein may be used in the discovery and development of antiviral compounds. For sequences containing an open reading frame (ORF) with appropriate initiation and termination codons, the encoded protein upon expression can be used as a target for the screening of antiviral drugs. Additionally, the DNA sequences encoding preferably the amino terminal regions of the encoded protein, or regions immediately upstream therefrom, can be used to construct antisense sequences to control the expression of the coding sequence of interest. Furthermore, many of the sequences disclosed herein also provide regions upstream and downstream from the encoding sequence. These sequences are useful as a source of regulatory elements for the control of viral gene expression. Such sequences are conveniently isolated by restriction enzyme action or synthesized chemically and introduced, for example, into promoter identification strains. These strains contain a reporter structural gene sequence located downstream from a restriction site such that if an active promoter is inserted, the reporter gene will be expressed.

Although each of the sequences may be employed as described above, this invention also provides several means for identifying particularly useful target genes. The first of these approaches entails searching appropriate databases for sequence matches in related organisms. Thus, if a homologue exists, the HSV-2-like form of this gene would likely play an analogous role. For example, a HSV-2 protein identified as homologous to a cell surface protein in another organism would be useful as a vaccine candidate. To the extent such homologies have been identified for the sequences disclosed herein they are reported along with the encoding sequence in the Tables.

A number of methods can be used to identify genes which are essential to survival per se, or essential to the establishmentymaintenance of an infection. Identification of an ORF unknown by one of these methods yields additional information about its function and permits the selection of such an ORF for further development as a screening target. Briefly, these approaches include: generation of temperature sensitive mutations (Weller, S.K., et al., Virology 130:290-305 (1983)), site specific insertion or deletion of a viral gene; a method based on selection of recombinant molecules generated by double recombination through homologous sequencees between intact viral DNA molecules and a DNA fragment containing an insertion or deletion and a selectable marker (Post, L.E., et al., Cell 25:227- 32 (1981)), and also by insertional mutagenesis using transposons; a method taking advantage of the random insertion of the DNA phage miniMu into target plasmid DNAs (Jenkins, F.J., et al., Proc. Nat'l. Acad. Sci. USA 82:4773-4777 (1985)). Each of these techniques may have advantages or disadvantages depending on the particular application. The skilled artisan would choose the approach that is the most relevant with the particular end use in mind. For example, some genes might be recognised as essential for infection but in reality are only necessary for the initiation of infection and so their products would represent relatively unattractive targets for antivirals developed to cure established and chronic infections.

Use of these technologies when applied to the ORFs of the present invention enables identification of viral proteins expressed during infection, inhibitors of which would have utility in antiviral therapy. Glossary:

The following explanations are provided to facilitate understanding of certain terms used frequently herein, particularly in the Examples. The explanations are provided as a convenience and are not limitative of the invention.

HSV-2 BINDING MOLECULE, as used herein, refers to molecules or ions which bind or interact specifically with HSV-2 polypeptides or polynucleotides of the present invention, including, for example, enzyme substrates, cell membrane components and classical receptors. Binding between polypeptides of the invention and such molecules, including binding or interaction molecules may be exclusive to polypeptides of the invention, which is preferred, or it may be highly specific for polypeptides of the invention, which is also preferred, or it may be highly specific to a group of proteins that includes polypeptides of the invention, which is preferred, or it may be specific to several groups of proteins at least one of which includes a polypeptide of the invention. Binding molecules also include antibodies and antibody-derived reagents that bind specifically to polypeptides of the invention.

GENETIC ELEMENT generally means a polynucleotide comprising a region that is important to the viral life cycle, a polynucleotide comprising a region that encodes a polypeptide or a polynucleotide region that regulates replication, transcription or translation or other processes important to expression of the polypeptide in a host cell, or a polynucleotide comprising both a region that encodes a polypeptide and a region operably linked thereto that regulates expression. Genetic elements may be comprised within a vector that replicates as an episomal element; that is, as a molecule physically independent of the host cell genome. They may be comprised within plasmids. Genetic elements also may be comprised within a host cell genome; not in their natural state but, rather, following manipulation such as isolation, cloning and introduction into a host cell in the form of purified DNA or in a vector, among others.

HOST CELL is a cell which has been transformed or transfected, or is capable of transformation or transfection by an exogenous polynucleotide sequence.

IDENTITY as known in the art, is a relationship between two or more polypeptide sequences or two or more polynucleotide sequences, as determined by comparing the sequences. In the art, "identity" also means the degree of sequence relatedness between polypeptide or polynucleotide sequences, as the case may be, as determined by the match between strings of such sequences. "Identity" and "similarity" can be readily calculated by known methods, including but not limited to those described in (Computational Molecular Biology, Lesk, A.M., ed., Oxford University Press, New York, 1988; Biocomputing: Informatics and Genome Projects, Smith, D.W., ed., Academic Press, New York, 1993; Computer Analysis of Sequence Data, Part I, Griffin, A.M., and Griffin, H.G., eds., Humana Press, New Jersey, 1994; Sequence Analysis in Molecular Biology, von Heinje, G., Academic Press, 1987; and Sequence Analysis Primer, Gribskov, M. and Devereux, J., eds., M Stockton Press, New York, 1991; and Carillo, H., and Lipman, D., SIAM J. Applied Math., 48: 1073 (1988). Preferred methods to determine identity are designed to give the largest match between the sequences tested. Methods to determine identity and similarity are codified in publicly available computer programs. Preferred computer program methods to determine identity and similarity between two sequences include, but are not limited to, the GCG program package (Devereux, J., et al., Nucleic Acids Research 12(1): 387 (1984)), BLASTP, BLASTN, and FASTA (Atschul, S.F. et al., J. Molec. Biol. 215: 403-410 (1990). The BLAST X program is publicly available from NCBI and other sources (BLAST Manual, Altschul, S., et al, NCBI NLM NIH Bethesda, MD 20894; Altschul, S., et al., J. Mol. Biol. 215: 403-410 (1990). As an illustration, by a polynucleotide having a nucleotide sequence having at least, for example, 95% "identity" to a reference nucleotide sequence it is intended that the nucleotide sequence of the tested polynucleotide is identical to the reference sequence except that the polynucleotide sequence may include up to five point mutations per each 100 nucleotides of the reference nucleotide sequence. In other words, to obtain a polynucleotide having a nucleotide sequence at least 95% identical to a reference nucleotide sequence, up to 5% of the nucleotides in the reference sequence may be deleted or substituted with another nucleotide, or a number of nucleotides up to 5% of the total nucleotides in the reference sequence may be inserted into the reference sequence. These mutations of the reference sequence may occur at the 5' or 3' terminal positions of the reference nucleotide sequence or anywhere between those terminal positions, interspersed either individually among nucleotides in the reference sequence or in one or more contiguous groups within the reference sequence. Analogously, by a polypeptide having an amino acid sequence having at least, for example, 95% identity to a reference amino acid sequence is intended that the test amino acid sequence of the polypeptide is identical to the reference sequence except that the polypeptide sequence may include up to five amino acid alterations per each 100 amino acids of the reference amino acid. In other words, to obtain a polypeptide having an amino acid sequence at least 95% identical to a reference amino acid sequence, up to 5% of the amino acid residues in the reference sequence may be deleted or substituted with another amino acid, or a number of amino acids up to 5% of the total amino acid residues in the reference sequence may be inserted into the reference sequence. These alterations of the reference sequence may occur at the amino or carboxy terminal positions of the reference amino acid sequence or anywhere between those terminal positions, interspersed either individually among residues in the reference sequence or in one or more contiguous groups within the reference sequence.

ISOLATED means altered "by the hand of man" from its natural state; i.e., that, if it occurs in nature, it has been changed or removed from its original environment, or both. For example, a naturally occurring polynucleotide or a polypeptide naturally present in a living organism in its natural state is not "isolated," but the same polynucleotide or polypeptide separated from the coexisting materials of its natural state is "isolated", as the term is employed herein. For example, with respect to polynucleotides, the term isolated means that it is separated from the genome and cell in which it naturally occurs. As part of or following isolation, such polynucleotides can be joined to other polynucleotides, such as DNAs, for mutagenesis, to form fusion proteins, and for propagation or expression in a host, for instance. The isolated polynucleotides, alone or joined to other polynucleotides such as vectors, can be introduced into host cells, in culture or in whole organisms. Introduced into host cells in culture or in whole organisms, such DNAs still would be isolated, as the term is used herein, because they would not be in their naturally occurring form or environment. Similarly, the polynucleotides and polypeptides may occur in a composition, such as a media formulations, solutions for introduction of polynucleotides or polypeptides, for example, into cells, compositions or solutions for chemical or enzymatic reactions, for instance, which are not naturally occurring compositions, and, therein remain isolated polynucleotides or polypeptides within the meaning of that term as it is employed herein.

POLYNUCLEOΗDE(S) generally refers to any polyribonucleotide or polydeoxribonucleotide, which may be unmodified RNA or DNA or modified RNA or DNA. Thus, for instance, polynucleotides as used herein refers to, among others, single-and double- stranded DNA, DNA that is a mixture of single- and double-stranded regions or single-, double- and triple-stranded regions, single- and double-stranded RNA, and RNA that is mixture of single- and double-stranded regions, hybrid molecules comprising DNA and RNA that may be single-stranded or, more typically, double-stranded, or triple-stranded, or a mixture of single- and double-stranded regions. In addition, polynucleotide as used herein refers to triple-stranded regions comprising RNA or DNA or both RNA and DNA. The strands in such regions may be from the same molecule or from different molecules. The regions may include all of one or more of the molecules, but more typically involve only a region of some of the molecules. One of the molecules of a triple-helical region often is an oligonucleotide. As used herein, the term polynucleotide includes DNAs or RNAs as described above that contain one or more modified bases. Thus, DNAs or RNAs with backbones modified for stability or for other reasons are "polynucleotides" as that term is intended herein. Moreover, DNAs or RNAs comprising unusual bases, such as inosine, or modified bases, such as tritylated bases, to name just two examples, are polynucleotides as the term is used herein. It will be appreciated that a great variety of modifications have been made to DNA and RNA that serve many useful purposes known to those of skill in the art. The term polynucleotide as it is employed herein embraces such chemically, enzymatically or metabolically modified forms of polynucleotides, as well as the chemical forms of DNA and RNA characteristic of viruses and cells, including inter alia, simple and complex cells. The term polynucleotide(s) embrace short polynucleotides often referred as oligonucleotides.

POLYPEPTIDES, as used herein, includes all polypeptides as described below. The basic structure of polypeptides is well known and has been described in innumerable textbooks and other publications in the art. In this context, the term is used herein to refer to any peptide or protein comprising two or more amino acids joined to each other in a linear chain by peptide bonds. As used herein, the term refers to both short chains, which also commonly are referred to in the art as peptides, oligopeptides and oligomers, for example, and to longer chains, which generally are referred to in the art as proteins, of which there are many types. It will be appreciated that polypeptides often contain amino acids other than the 20 amino acids commonly referred to as the 20 naturally occurring amino acids, and that many amino acids, including the terminal amino acids, may be modified in a given polypeptide, either by natural processes, such as processing and other post-translational modifications, but also by chemical modification techniques which are well known to the art. Even d e common modifications that occur naturally in polypeptides are too numerous to list exhaustively here, but they are well described in basic texts and in more detailed monographs, as well as in a voluminous research literature, and they are well known to those of skill in the art. Among the known modifications which may be present in polypeptides of the present are, to name an illustrative few, acetylation, acylation, ADP-ribosylation, amidation, covalent attachment of flavin, covalent attachment of a heme moiety, covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent attachment of phosphotidylinositol, cross-linking, cyclization, disulfide bond formation, demethylation, formation of covalent cross-links, formation of cystine, formation of pyroglutamate, formylation, gamma-carboxylation, glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer-RNA mediated addition of amino acids to proteins such as arginylation, and ubiquitination. Such modifications are well known to those of skill and have been described in great detail in the scientific literature. Several particularly common modifications, glycosylation, lipid attachment, sulfation, gamma-carboxylation of glutamic acid residues, hydroxylation and ADP-ribosylation, for instance, are described in most basic texts, such as, for instance PROTEINS - STRUCTURE AND MOLECULAR PROPERTIES, 2nd Ed., T. E. Creighton, W. H. Freeman and Company, New York (1993). Many detailed reviews are available on this subject, such as, for example, those provided by Wold, F., Posttranslational Protein Modifications: Perspectives and Prospects, pgs. 1-12 in POSTTRANSLATIONAL COVALENT MODIFICATION OF PROTEINS, B. C. Johnson, Ed., Academic Press, New York (1983); Seifter et al, Meth. Enzymol. 182:626-646 (1990) and Rattan et aL, Protein Synthesis: Posttranslational Modifications and Aging, Ann. N.Y. Acad. Sci. 663: 48-62 (1992). It will be appreciated, as is well known and as noted above, that polypeptides are not always entirely linear. For instance, polypeptides may be branched as a result of ubiquitination, and they may be circular, with or without branching, generally as a result of posttranslation events, including natural processing event and events brought about by human manipulation which do not occur naturally. Circular, branched and branched circular polypeptides may be synthesized by non-translation natural process and by entirely synthetic meuiods, as well. Modifications can occur anywhere in a polypeptide, including the peptide backbone, the amino acid side-chains and the amino or carboxyl termini. In fact, blockage of the amino or carboxyl group in a polypeptide, or both, by a covalent modification, is common in naturally occurring and synthetic polypeptides and such modifications may be present in polypeptides of the present invention, as well. For instance, the amino terminal residue of polypeptides made in E. coli or other cells, prior to proteolytic processing, almost invariably will be N-formylmethionine. During post-translational modification of the peptide, a methionine residue at the NH₂-terminus may be deleted. Accordingly, this invention contemplates the use of both the methionine-containing and the methionineless amino terminal variants of the protein of the invention. The modifications that occur in a polypeptide often will be a function of how it is made. For polypeptides made by expressing a cloned gene in a host, for instance, the nature and extent of the modifications in large part will be determined by the host cell posttranslational modification capacity and the modification signals present in the polypeptide amino acid sequence. For instance, as is well known, glycosylation often does not occur in bacterial hosts such as, for example, E. coli. Accordingly, when glycosylation is desired, a polypeptide should be expressed in a glycosylating host, generally a eukaryotic cell. Insect cells often carry out the same posttranslational glycosylations as do mammalian cells and, for this reason, insect cell expression systems have been developed to express efficiently mammalian proteins having native patterns of glycosylation. Similar considerations apply to other modifications. It will be appreciated that the same type of modification may be present in the same or varying degree at several sites in a given polypeptide. Also, a given polypeptide may contain many types of modifications. In general, as used herein, the term polypeptide encompasses all such modifications, particularly those that are present in polypeptides synthesized by expressing a polynucleotide in a host cell.

VARIANT(S) as the term is used herein, is a polynucleotide or polypeptide that differs from a reference polynucleotide or polypeptide respectively, but retains essential properties. A typical variant of a polynucleotide differs in nucleotide sequence from another, reference polynucleotide. Changes in the nucleotide sequence of the variant may or may not alter the amino acid sequence of a polypeptide encoded by the reference polynucleotide. Nucleotide changes may result in amino acid substitutions, additions, deletions, fusions and truncations in the polypeptide encoded by the reference sequence, as discussed below. A typical variant of a polypeptide differs in amino acid sequence from another, reference polypeptide. Generally, differences are limited so that the sequences of the reference polypeptide and the variant are closely similar overall and, in many regions, identical. A variant and reference polypeptide may differ in amino acid sequence by one or more substitutions, additions, deletions in any combination. A substituted or inserted amino acid residue may or may not be one encoded by the genetic code. A variant of a polynucleotide or polypeptide may be a naturally occurring such as an allelic variant, or it may be a variant that is not known to occur naturally. Non-naturally occurring variants of polynucleotides and polypeptides may be made by mutagenesis techniques, by direct synthesis, and by other recombinant methods known to skilled artisans.

Deposit:

HSV-2, strain SB5 has been deposited at the American Type Culture Collection under accession number VR-2546 on October 31, 1996.

The deposits referred to herein will be maintained under the terms of the Budapest Treaty on the International Recognition of the Deposit of Micro-organisms for Purposes of Patent Procedure. These deposits are provided merely as convenience to those of skill in the art and are not an admission that a deposit is required under 35 U.S.C. § 112. The sequence of the polynucleotides contained in the deposited material, as well as the amino acid sequence of the polypeptides encoded thereby, are incorporated herein by reference and are controlling in the event of any conflict with any description of sequences herein. A license may be required to make, use or sell the deposited material, and no such license is hereby granted. Viral Strain and Genome:

The nucleotide sequences disclosed herein can be obtained by synthetic chemical techniques known in the art or can be obtained from HSV-2, strain SB5 by probing a DNA preparation with probes constructed from the particular sequences disclosed herein. Alternatively, oligonucleotides derived from a disclosed sequence can act as PCR primers in a process of PCR-based cloning of the sequence from a viral genomic source. It is recognised that such sequences will also have utility in diagnosis of the stage of infection and type of infection the pathogen has attained.

The present invention relates to novel HSV-2 polypeptides and polynucleotides encoding same, among other things, as described in greater detail below. The invention relates especially to HSV-2 molecules having the nucleotide and amino acid sequences set out in Tables 1-4 and to the HSV-2 nucleotide and amino acid sequences of the DNA isolatable from Deposit No. ATTC VR-2546, which is herein referred to as "the deposited organism" or as the "DNA of the deposited organism." It will be appreciated that the nucleotide and amino acid sequences set out in Tabled 1-4 were obtained by sequencing the DNA of the deposited organism. Hence, the sequence of the deposited clone is controlling as to any discrepancies between it (and the sequence it encodes) and the sequences of the Tables.

The present invention also relates to additional polynucleotide sequences disclosed herein, which are RNAs transcribed from the DNAs disclosed herein but which may or may not be translated into protein. Such polynucleotides are known in HSV-1 and outer herpes viruses. Polynucleotides

In accordance with one aspect of the present invention, there are provided isolated polynucleotides which encode HSV-2 polypeptides having the deduced amino acid sequence of Tables 1-4. It is preferred that these polynucleotides be one of those set forth in Tables 1, 2 or 3. The skilled artisan can readily determine the polynucleotide sequence of such preferred polynucleotides by reference to the ORF start and stop positions set forth in Tables 1-4.

Using the information provided herein, such as the polynucleotide sequence set out in Tables 1-3, a polynucleotide of the present invention encoding HSV-2 polypeptide may be obtained using standard cloning and screening procedures. To obtain the polynucleotide encoding the protein using the DNA sequences given in Tables 1-3 typically a library of clones of chromosomal DNA of HSV-2 strain SB5 in E. coli or some other suitable host is probed with a radiolabelled oligonucleotide, preferably a 17mer or longer, derived from a sequence of Tables 1-3. Clones carrying DNA identical to that of the probe can then be distinguished using high stringency washes. By sequencing the individual clones thus identified with sequencing primers designed from the original sequence it is then possible to extend the sequence in both directions to determine the full gene sequence. Conveniently such sequencing is performed using denatured double stranded DNA prepared from a plasmid clone. Suitable techniques are described by Maniatis, T., Fritsch, E.F. and Sambrook, J. in MOLECULAR CLONING, A Laboratory Manual (2nd edition 1989 Cold Spring Harbor Laboratory, see Screening By Hybridization 1.90 and Sequencing Denatured Double-Stranded DNA Templates 13.70

The DNA sequences set out in Tables 1, 2 and 3 each contain at least one open reading frame encoding a protein having at least about the number of amino acid residues set forth in Table 1-3. The start and stop codons of each open reading frame are the first three and the last three nuclotides of each polynucleotide set forth in Table 1, 2 and 3. Certain HSV-2 sequences of the invention are structurally related to sequences encoding other proteins of the herpes family, as shown by comparing the sequences of the Tables with that of sequences reported in the literature. Moreover, certain polynucleotides and polypeptides of the invention are structurally related to known. These proteins exhibit greatest homology to the homologue listed in Tables 1, 2, 3 and 4 from among the known proteins. The invention provides a polynucleotide sequence identical over its entire length to each coding sequence in Tables 1-3. Also provided by the invention is the coding sequence for the mature polypeptide or a fragment thereof, by itself as well as the coding sequence for the mature polypeptide or a fragment in reading frame with other coding sequence, such as those encoding a leader or secretory sequence, a pre-, or pro- or prepro- protein sequence. The polynucleotide may also contain non-coding sequences, including for example, but not limited to non-coding 5' and 3' sequences, such as the transcribed, non-translated sequences, termination signals, ribosome binding sites, sequences that stabilize mRNA, introns, polyadenylation signals, and additional coding sequence which encode additional amino acids. For example, a marker sequence mat facilitates purification of the fused polypeptide can be encoded. In certain embodiments of the invention, the marker sequence is a hexa-histidine peptide, as provided in the pQE vector (Qiagen, Inc.) and described in Gentz et al., Proc. Natl. Acad. Sci., USA 86: 821- 824 (1989), or an HA tag (Wilson et al., Cell 37: 767 (1984). Polynucleotides of the invention also include, but are not limited to, polynucleotides comprising a structural gene and its naturally associated sequences that control gene expression. The invention also includes polynucleotides of the formula:

X-(R₁)_m-(R₂)-(R₃)_n-Y wherein, at the 5' end of the molecule, X is hydrogen, and at the 3' end of the molecule, Y is hydrogen or a metal, R_j and R3 is any nucleic acid residue, n and/or m is an integer between 1 and 3000 or zero, and R₂ is a nucleic acid sequence of the invention, particularly a nucleic acid sequence selected from the group set forth in Tables 1, 2 and 3, as well as a ORF sequence selected from the group set forth in Tables 1, 2, 3 and 4 (as indicated by the reading frame numbering). In the polynucleotide formula above R₂ is oriented so that its 5' end residue is at the left, bound to R_j and its 3' end residue is at the right, bound to R3. Any stretch of nucleic acid residues denoted by either R group, where n and/or m is greater than 1, may be either a heteropolymer or a homopolymer, preferably a heteropolymer. In a preferred embodiment n and/or m is an integer between 1 and 1000, or 2000 or 3000.

The term "polynucleotide encoding a polypeptide" as used herein encompasses polynucleotides that include a sequence encoding a polypeptide of the invention, particularly a viral polypeptide and more particularly a polypeptide of the HSV-2 having an amino acid sequence set out in Table 1, 2, 3 or 4. The term also encompasses polynucleotides that include a single continuous region or discontinuous regions encoding the polypeptide (for example, interrupted by integrated phage or an insertion sequence or editing) together with additional regions, that also may contain coding and/or non-coding sequences.

The invention further relates to variants of the polynucleotides described herein that encode for variants of the polypeptide having the deduced amino acid sequence of Tables 1, 2, 3 and 4. Variants that are fragments of the polynucleotides of the invention may be used to synthesize full-length polynucleotides of the invention.

Polynucleotides of the present invention may be in the form of RNA, such as mRNA, or in the form of DNA, including, for instance, cDNA and genomic DNA obtained by cloning or produced by chemical synthetic techniques or by a combination thereof. The DNA may be double-stranded or single-stranded. Single-stranded DNA may be the coding strand, also known as the sense strand, or it may be the non-coding strand, also referred to as die anti-sense strand.

The coding sequence which encodes the polypeptide may be identical to the coding sequence of the polynucleotide shown in Tables 1-4. It also may be a polynucleotide with a different sequence, which, as a result of the redundancy (degeneracy) of the genetic code, encodes the polypeptides of Tables 1-4.

Particularly preferred embodiments are polynucleotides encoding polypeptide variants, mat have the amino acid sequence of a polypeptide of Tables 1, 2, 3 and/or 4 in which several, a few, 5 to 10, 1 to 5, 1 to 3, 2, 1 or no amino acid residues are substituted, deleted or added, in any combination. Especially preferred among these are silent substitutions, additions and deletions, that do not alter the properties and activities of such polynucleotide.

Further preferred embodiments of the invention are polynucleotides that are at least 50%, 60% or 70% identical over their entire lengtii to a polynucleotide encoding a polypeptide having the amino acid sequence set out in Tables 1, 2, 3 or 4, and polynucleotides that are complementary to such polynucleotides. Alternatively, most highly preferred are polynucleotides that comprise a region that is at least 80% identical over its entire length to a polynucleotide encoding a polypeptide of the deposited strain and polynucleotides complementary thereto. In this regard, polynucleotides at least 90% identical over their entire length to the same are particularly preferred, and among these particularly preferred polynucleotides, those with at least 95% are especially preferred. Furthermore, those with at least 97% are highly preferred among those with at least 95%, and among these those with at least 98% and at least 99% are particularly highly preferred, with at least 99% being the most preferred.

A preferred embodiment is an isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of: a polynucleotide having at least a 50% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of Tables 1, 2, 3, or 4 and obtained from a prokaryotic species other than HSV-2; and a polynucleotide encoding a polypeptide comprising an amino acid sequence which is at least 50% identical to the amino acid sequence of Tables 1, 2, 3 or 4 and obtained from a prokaryotic species other than HSV-2. Preferred embodiments are polynucleotides that encode polypeptides that retain substantially the same biological function or activity as the mature polypeptide encoded by the DNA of Tables l, 2, 3 or4. The invention further relates to polynucleotides that hybridize to the herein above- described sequences. In this regard, the invention especially relates to polynucleotides that hybridize under stringent conditions to the herein above-described polynucleotides. As herein used, the terms "stringent conditions" and "stringent hybridization conditions" mean hybridization will occur only if there is at least 95% and preferably at least 97% identity between the sequences. An example of stringent hybridization conditions is overnight incubation at 42°C in a solution comprising: 50% formamide, 5x SSC (150mM NaCl, 15mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5x Denhardt's solution, 10% dextran sulfate, and 20 micrograms/ml denatured, sheared salmon sperm DNA, followed by washing the hybridization support in O.lx SSC at about 65°C. Hybridization and wash conditions are well known and exemplified in Sambrook, et al., Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor, N.Y., (1989), particularly Chapter 11 therein.

The invention also provides a polynucleotide consisting essentially of a polynucleotide sequence obtainable by screening an appropriate library containing the complete gene for a polynucleotide sequence set forth in Tables 1, 2, 3 or 4 under stringent hybridization conditions with a probe having the sequence of said polynucleotide sequence or a fragment thereof; and isolating said DNA sequence. Fragments useful for obtaining such a polynucleotide include, for example, probes and primers described elsewhere herein.

As discussed additionally herein regarding polynucleotide assays of the invention, for instance, polynucleotides of the invention as discussed above, may be used as a hybridization probe for RNA, cDNA and genomic DNA to isolate full-length cDNAs and genomic clones encoding a polypeptide and to isolate cDNA and genomic clones of other genes that have a high sequence similarity to a polynucleotide set forth in Table 1, 2, 3 or 4. Such probes generally will comprise at least 15 bases. Preferably, such probes will have at least 30 bases and may have at least 50 bases. Particularly preferred probes will have at least 30 bases and will have 50 bases or less.

For example, the coding region of each gene that comprises or is comprised by a polynucleotide set forth in Table 1, 2, 3 or 4 may be isolated by screening using a DNA sequence provided in Table 1, 2, 3 or 4 to synthesize an oligonucleotide probe. A labeled oligonucleotide having a sequence complementary to that of a gene of the invention is then used to screen a library of cDNA, genomic DNA or mRNA to determine which members of the library the probe hybridizes to. Polynucleotides of the invention that are oligonucleotides derived from the a polynucleotide or polypeptide sequence set forth in Table 1 , 2, 3 or 4 may be used in the processes herein as described, but preferably for PCR, to determine whether or not the polynucleotides identified herein in whole or in part are transcribed in virus in infected tissue. It is recognized that such sequences will also have utility in diagnosis of the stage of infection and type of infection the pathogen has attained.

The invention also provides polynucleotides that may encode a polypeptide that is the mature protein plus additional amino or carboxyl-terminal amino acids, or amino acids interior to the mature polypeptide (when the mature form has more than one polypeptide chain, for instance). Such sequences may play a role in processing of a protein from precursor to a mature form, may allow protein transport, may lengthen or shorten protein half-life or may facilitate manipulation of a protein for assay or production, among other things. As generally is the case in vivo, the additional amino acids may be processed away from the mature protein by cellular enzymes. A precursor protein, having the mature form of the polypeptide fused to one or more prosequences may be an inactive form of the polypeptide. When prosequences are removed such inactive precursors generally are activated. Some or all of the prosequences may be removed before activation. Generally, such precursors are called proproteins.

The DNA may also comprise a promoter region which functions to direct the transcription of the mRNA encoding the HSV-2 of this invention . Such promoters may be independently useful to direct the transcription of heterologous genes in recombinant expression systems. Polyadenylation and splicing signal sequences are also present in the polynucleotide sequence and may be useful as gene expression signal in heterologous gene expression vectors and constructs. The polynucleotides and polypeptides of the invention may be employed, for example, as research reagents and materials for discovery of treatments of and diagnostics for disease, particularly human disease, as further discussed herein relating to polynucleotide assays.

The polynucleotides of the invention that are oligonucleotides may also be used as nucleic acid amplification primers, such as PCR primers, in the process herein described to determine whether or not the HSV-2 genes identified herein in whole or in part are present or transcribed in infected tissue. It is recognized that such sequences will also have utility in diagnosis of the stage of infection and type of infection the pathogen has attained.

In addition to the uses mentioned above for the polynucleotides of this invention, the following applications are also contemplated by this invention. Inter alia, the polynucleotides disclosed herein or portions thereof, may be used as probes to discover mRNA transcripts synthesized during productive and latent HSV-2 infections, for example by Northern blot, nuclease protection, and primer extension experiments. Novel transcripts in turn can lead to the discovery of new HSV-2 proteins not deducible from the genome sequences directly. The sequences, or portions thereof, may be used to discover antisense inhibitors of virus replication and novel therapeutics based on antisense mechanisms. The sequences, or portions thereof, may be used to prepare novel gene therapy vectors. The sequences or portions thereof may be used as a basis for the generation of DNA- or RNA-containing oligonucleotides designed to form a triplex with duplex DNA, for use as analytical tools, diagnostics or therapeutics. Nucleic acid sequences, or portion thereof, can be used to generate cell lines useful for diagnostics or screening. The DNA sequences can be used to predict restriction enzyme sites useful for replacing the gene in the viral genome with a marker gene such as lac z or green flourescent protein. Such a replacement is useful in defining the biological role of the gene in the viral life cycle. These gene knockout experiments are useful to discover genes which are likely to be high quality drug discovery targets (essential genes) or good locations for foreign genes for the purposes of gene therapy (non- essential genes) through an HSV-2 viral vector. Such gene replacements are also useful for discovering virulence factors, for example by comparing the pathogenicity of the modified virus with the unmodified virus or through the ease of identifying a marker gene such as lacz.

In addition to the standard A, G, C, T U representations for nucleic acid bases, the term "N" is also used. "N" means that any of the four DNA or RNA bases may appear at such a designated position in the DNA or RNA sequence, except it is preferred that N is not a base that when taken in combination with adjacent nucleotide positions, when read in the correct reading frame, would have the effect of generating a premature termination codon in such reading frame.

In sum, a polynucleotide of the invention may encode a mature protein, a mature protein plus a leader sequence (which may be referred to as a preprotein), a precursor of a mature protein having one or more prosequences that are not the leader sequences of a preprotein, or a preproprotein, which is a precursor to a proprotein, having a leader sequence and one or more prosequences, which generally are removed during processing steps that produce active and mature forms of the polypeptide. Polypeptides The present invention further relates to HSV-2 polypeptides that have the deduced amino acid sequences of the polypeptides defined by amino acid sequence in Tables 1-4. The invention also relates to fragments, analogs and deπvatives of these polypeptides The terms "fragment," "derivative" and "analog" when referring to the polypeptides of the invention mean a polypeptide which retains essentially the same biological function or activity as such polypeptide Fragments, deπvatives and analogs that retain at least 90% of the biological activity of the native HSV-2 protein are preferred Fragments, deπvatives and analogs that retain at least 95% of the activity of the native HSV-2 protein are preferred Thus, an analog includes a proprotein which can be activated by cleavage of the proprotein portion to produce an active mature polypeptide

The polypeptide of the present invention may be a recombinant polypeptide, a natural polypeptide or a synthetic polypeptide In certain preferred embodiments it is a recombinant polypepftde

The fragment, deπvative or analog of the polypeptides of the invention may be (I) one in which one or more of the ammo acid residues are substituted with a conserved or non- conserved ammo acid residue (preferably a conserved amino acid residue) and such substituted amino acid residue may or may not be one encoded by the genetic code, or (n) one in which one or more of the ammo acid residues includes a substituent group, or (in) one in which the mature polypeptide is fused with another compound, such as a compound to increase the half-life of the polypeptide (for example, polyethylene glycol), or (iv) one in which the additional amino acids are fused to the mature polypeptide, such as a leader or secretory sequence or a sequence which is employed for puπfication of the mature polypeptide or a proprotein sequence Such fragments, deπvatives and analogs are deemed to be obtained by those of ordinary skill in the art, from the teachings herein

Among preferred vaπants are those that vary from a reference by conservative amino acid substitutions Such substitutions are those that substitute a given ammo acid in a polypeptide by another ammo acid of like characteπstics Typically seen as conservative substitutions are the replacements, one for another, among the aliphatic amino acids Ala, Val, Leu and De, interchange of the hydroxyl residues Ser and Thr, exchange of the acidic residues Asp and Glu, substitution between the amide residues Asn and Gin, exchange of the basic residues Lys and Arg and replacements among die aromatic residues Phe, Tyr Further particularly preferred m this regard are vaπants, analogs, denvatives and fragments having the ammo acid sequence of one or more of the HSV-2 polypeptides of the invention, in which several, a few, 5 to 10, 1 to 5, 1 to 3, 2, 1 or no ammo acid residues are substituted, deleted or added, in any combination Especially preferred among these are silent substitutions, additions and deletions, which do not alter the properties and activities of the HSV- 2 protein. Also especially preferred in this regard are conservative substitutions. Most highly preferred are polypeptides having the amino acid sequences of Tables 1-4 without substitutions. The invention also includes polypeptides of the formula:

X-(R₁)_n-(R₂)-(R₃)_m-Y wherein, at the amino terminus, X is hydrogen, and at the carboxyl terminus, Y is hydrogen or a metal, R\ and R3 are any amino acid residue, n and/or m is an integer between 1 and 2000 or zero, and R₂ is an amino acid sequence of the invention, particularly an amino acid sequence selected from the group set forth in Tables 1, 2, 3 and 4. In the formula above R is oriented so that its amino terminal residue is at the left, bound to R_j and its carboxy terminal residue is at the right, bound to R3. Any stretch of amino acid residues denoted by either R group, where n and/or m is greater than 1, may be either a heteropolymer or a homopolymer, preferably a heteropolymer. In preferred embodiments n and or m is an integer between 1 and 1000 or 2000. The polypeptides and polynucleotides of the present invention are preferably provided in an isolated form, and preferably are purified to homogeneity. The polypeptides of the present invention include the polypeptides of Tables 1 -4, in particular the mature polypeptide as well as polypeptides which have at least 60%, 70% or 80% identity to one or more of the polypeptides of Tables 1-4 and preferably at least 90% similarity to one or more of the polypeptides of Tables 1-4 and more preferably at least 95% similarity; and still more preferably at least 95% identity to one or more of the polypeptides of Tables 1-4 and also include portions of such polypeptides with such portion of the polypeptide generally containing at least 30 contiguous amino acids and more preferably at least 50 contiguous amino acids.

In addition to the uses mentioned above for the polypeptides of this invention, the following applications are also contemplated by this invention. Inter alia, the polypeptides disclosed herein or portions thereof which have enzymatic activity or structural functionality are useful as a source of those proteins for screening and or therapy. Such polypeptides may be identified by homology for example, to HSV1 polypeptides that code for proteins with known function (e.g., helicases, kinases, proteases). Use of polypeptides of the invention for screening or therapy based upon functionality predicted by homology match is a particularly preferred aspect of this invention. Also the polypeptides derived from the deposited strain ATCC VR-2546 herein can be used for comparison with sequences from other HSV-2 strains in the public domain, for example, comparison of the polypeptides of the invention with strain HG52 may be useful in the discovery of virulence factors, since HG52 is avirulent in mouse and guinea pig infection models and HSV-2 SB5 is virulent. Similarly, public domain homolog from strain MS may be useful in the discovery of virulence factors since there are major differences in the CNS pathogenesis in animal models between strains MS and SB5.

In addition to the standard single and triple letter representations for amino acids, the term "X" or "Xaa" is also used. "X" and "Xaa" mean that any of the twenty naturally occuring amino acids may appear at such a designated position in the polypeptide sequence.

Fragments

Fragments or portions of the polypeptides of the present invention may be employed for producing the corresponding full-length polypeptide by peptide synthesis; therefore, the fragments may be employed as intermediates for producing the full-length polypeptides. Fragments or portions of the polynucleotides of the present invention may be used to synthesize full-length polynucleotides of the present invention.

Also among preferred embodiments of this aspect of the present invention are polypeptides comprising fragments of HSV-2, most particularly fragments of HSV-2 having the amino acid sequences set out in Tables 1-4, and variants and derivatives thereof. In this regard, a fragment is a polypeptide having an amino acid sequence that entirely is the same as part but not all of the amino acid sequence of the aforementioned HSV-2 polypeptides and variants or derivatives thereof.

Such fragments may be "free-standing," i.e., not part of or fused to other amino acids or polypeptides, or they may be comprised within a larger polypeptide of which they form a part or region. When comprised within a larger polypeptide, the presently discussed fragments most preferably form a single continuous region. However, several fragments may be comprised within a single larger polypeptide. For instance, certain preferred embodiments relate to a fragment of a HSV-2 polypeptide of the present comprised within a precursor polypeptide designed for expression in a host and having heterologous pre and pro-polypeptide regions fused to the amino terminus of the HSV-2 fragment and an additional region fused to the carboxyl terminus of the fragment. Therefore, fragments in one aspect of the meaning intended herein, refers to the portion or portions of a fusion polypeptide or fusion protein derived from HSV-2.

Representative examples of polypeptide fragments of the invention, include, for example, those which have from about 5-15, 10-20, 15-40, 30-55, 41-75, 41-80, 41-90, 50-100, 75-100, 90-115, 100-125, and 110-140, 120-150, 200-300, 1-175, 1-600 or 1-1000 amino acids long. Particular examples of polypeptide fragments of the inventions that may be mentioned include fragments of 20-200 amino acids.

In this context about includes the particularly recited range and ranges larger or smaller by several, a few, 5, 4, 3, 2 or 1 amino acid at either extreme or at both extremes. Among especially preferred fragments of the invention are truncation mutants of HSV-2. Truncation mutants include HSV-2 polypeptides having the amino acid sequences of Tables 1-4, or of variants or derivatives thereof, except for deletion of a continuous series of residues (that is, a continuous region, part or portion) that includes the amino terminus, or a continuous series of residues that includes the carboxyl terminus or, as in double truncation mutants, deletion of two continuous series of residues, one including the amino terminus and one including the carboxyl terminus. Fragments having the size ranges set out above also are preferred embodiments of truncation fragments, which are especially preferred among fragments generally. Degradation forms of the polypeptides of the invention in a host cell are also preferred. Also preferred in this aspect of the invention are fragments characterized by structural or functional attributes of HSV-2. Preferred embodiments of the invention in this regard include fragments that comprise alpha-helix and alpha-helix forming regions ("alpha-regions"), beta- sheet and beta-sheet-forming regions ("beta-regions"), turn and rum-forming regions ("rum- regions"), coil and coil-forming regions ("coil-regions"), hydrophilic regions, hydrophobic regions, alpha amphipathic regions, beta amphipathic regions, flexible regions, surface-forming regions and high antigenic index regions of HSV-2.

Further preferred regions are those that mediate activities of HSV-2. Most highly preferred in this regard are fragments that have a chemical, biological or other activity of the particular HSV-2 protein , including those with a similar activity or an improved activity, or with a decreased undesirable activity. Routinely one generates the fragment by well-known methods then compares the activity of the fragment to the native protein in a convenient assay such as listed hereinbelow. Highly preferred in this regard are fragments that contain regions that are homologs in sequence, or in position, or in both sequence and to active regions of related polypeptides, such as the related polypeptides set out in Table 1. Among particularly preferred fragments in these regards are truncation mutants, as discussed above. Further preferred polynucleotide fragments are those that are antigenic or immunogenic in an animal, especially in a human.

It will be appreciated that the invention also relates to, among others, polynucleotides encoding the aforementioned fragments, polynucleotides that hybridize to polynucleotides encoding the fragments, particularly those that hybridize under stringent conditions, and polynucleotides, such as PCR primers, for amplifying polynucleotides that encode the fragments. In these regards, preferred polynucleotides are those that correspond to the preferred fragments, as discussed above. Vectors, host cells, expression:

The present invention also relates to vectors which comprise a polynucleotide or polynucleotides of the present invention, host cells which are genetically engineered with vectors of the invention and the production of polypeptides of the invention by recombinant techniques. Host cells can be genetically engineered to incorporate polynucleotides and express polypeptides of the present invention. Introduction of a polynucleotides into the host cell can be affected by calcium phosphate transfection, DEAE-dextran mediated transfection, transvection, microinjection, cationic lipid-mediated transfection, electroporation, transduction, scrape loading, ballistic introduction, infection or other methods. Such methods are described in many standard laboratory manuals, such as Davis et ah, BASIC METHODS IN MOLECULAR BIOLOGY,

(1986) and Sambrook et ah, MOLECULAR CLONING: A LABORATORY MANUAL, 2nd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (1989).

Polynucelotide constructs in host cells can be used in a conventional manner to produce the gene product encoded by the recombinant sequence. Alternatively, the polypeptides of the invention can be synthetically produced by conventional peptide synthesizers.

Mature proteins can be expressed in mammalian cells, yeast, bacteria, or other cells under the control of appropriate promoters. Cell-free translation systems can also be employed to produce such proteins using RNAs derived from the DNA constructs of the present invention. Appropriate cloning and expression vectors for use with prokaryotic and eukaryotic hosts are described by Sambrook et ah, MOLECULAR CLONING: A LABORATORY MANUAL, 2nd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (1989).

In accordance with this aspect of the invention the vector may be, for example, a plasmid vector, a single or double-stranded phage vector, a single or double-stranded RNA or DNA viral vector. Plasmids generally are designated herein by a lower case p preceded and/or followed by capital letters and or numbers, in accordance with standard naming conventions that are familiar to those of skill in the art. Starting plasmids disclosed herein are either commercially available, publicly available, or can be constructed from available plasmids by routine application of well known, published procedures. Many plasmids and other cloning and expression vectors that can be used in accordance with the present invention are well known and readily available to those of skill in the art.

Preferred among vectors, in certain respects, are those for expression of polynucleotides and polypeptides of the present invention. Generally, such vectors comprise -acting control regions effective for expression in a host operatively linked to the polynucleotide to be expressed. Appropriate trans-acting factors either are supplied by the host, supplied by a complementing vector or supplied by the vector itself upon introduction into the host. In certain preferred embodiments in this regard, the vectors provide for specific expression. Such specific expression may be inducible expression or expression only in certain types of cells or both inducible and cell-specific. Particularly preferred among inducible vectors are vectors that can be induced for expression by environmental factors that are easy to manipulate, such as temperature and nutrient additives. A variety of vectors suitable to this aspect of the invention, including constitutive and inducible expression vectors for use in prokaryotic and eukaryotic hosts, are well known and employed routinely by those of skill in the art.

A great variety of expression vectors can be used to express a polypeptide of the invention. Such vectors include, among others, chromosomal, episomal and virus-derived vectors, e.g., vectors derived from viral plasmids, from bacteriophage, from transposons, from yeast episomes, from insertion elements, from yeast chromosomal elements, from viruses such as baculoviruses, papova viruses, such as SV40, vaccinia viruses, adenoviruses, fowl pox viruses, pseudorabies viruses and retroviruses, and vectors derived from combinations thereof, such as those derived from plasmid and bacteriophage genetic elements, such as cosmids and phagemids, all may be used for expression in accordance with this aspect of the present invention. Generally, any vector suitable to maintain, propagate or express polynucleotides to express a polypeptide in a host may be used for expression in this regard.

The appropriate DNA sequence may be inserted into the vector by any of a variety of well-known and routine techniques, such as, for example, those set forth in Sambrook et al.. MOLECULAR CLONING, A LABORATORY MANUAL, 2nd Ed.; Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York (1989).

The DNA sequence in the expression vector is operatively linked to appropriate expression control sequence(s), including, for instance, a promoter to direct mRNA transcription. Representatives of such promoters include, but are not limited to, the phage lambda PL promoter, the E. coli lac, trp and tac promoters, the SV40 early and late promoters and promoters of retroviral LTRs.

In general, expression constructs will contain sites for transcription initiation and termination, and, in some instances, in the transcribed region, a ribosome binding site for translation. The coding portion of the mature transcripts expressed by the constructs will include a translation initiating AUG at the beginning and a teirnination codon appropriately positioned at the end of the polypeptide to be translated.

In addition, the constructs may contain control regions that regulate as well as engender expression. Generally, in accordance with many commonly practiced procedures, such regions will operate by controlling transcription, such as transcription factors, repressor binding sites and termination, among others.

Vectors for propagation and expression generally will include selectable markers and amplification regions, such as, for example, those set forth in Sambrook et al, MOLECULAR CLONING, A LABORATORY MANUAL, 2nd Ed.; Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York (1989).

Representative examples of appropriate hosts include bacterial cells, such as streptococci, staphylococci, E. coli, streptomyces and Bacillus subtilis cells; fungal cells, such as yeast cells and Aspergillus cells; insect cells such as Drosophila S2 and Spodoptera Sf9 cells; animal cells such as CHO, COS, HeLa, C127, 3T3, BHK, 293 and Bowes melanoma cells; and plant cells.

The following vectors, which are commercially available, are provided by way of example. Among vectors preferred for use in bacteria are pQE70, pQE60 and pQE-9, available from Qiagen; pBS vectors, Phagescript vectors, Bluescript vectors, pNH8A, pNHlόa, pNH18A, pNH46A, available from Stratagene; and ptrc99a, pKK223-3, pKK233-3, pDR540, pRTT5 available from Pharmacia, and pBR322 (ATCC 37017). Among preferred eukaryotic vectors are pWLNEO, pSV2CAT, pOG44, pXTl and pSG available from Stratagene; and pSVK3, pBPV, pMSG and pSVL available from Pharmacia. These vectors are listed solely by way of illustration of the many commercially available and well known vectors that are available to those of skill in the art for use in accordance with this aspect of the present invention. It will be appreciated that any other plasmid or vector suitable for, for example, introduction, maintenance, propagation or expression of a polynucleotide or polypeptide of the invention in a host may be used in this aspect of the invention.

Promoter regions can be selected from any desired gene using vectors that contain a reporter transcription unit lacking a promoter region, such as a chloramphenicol acetyl transferase ("CAT") transcription unit, downstream of restriction site or sites for introducing a candidate promoter fragment; i.e., a fragment that may contain a promoter. As is well known, introduction into the vector of a promoter-containing fragment at the restriction site upstream of the cat gene engenders production of CAT activity, which can be detected by standard CAT assays. Vectors suitable to this end are well known and readily available, such as pKK232-8 and pCM7. Promoters for expression of polynucleotides of the present invention include not only well known and readily available promoters, but also promoters that readily may be obtained by the foregoing technique, using a reporter gene.

Among known prokaryotic promoters suitable for expression of polynucleotides and polypeptides in accordance with the present invention are the E. coli lacl and lacZ and promoters, the T3 and T7 promoters, the gpt promoter, the lambda PR, PL promoters and the trp promoter.

Among known eukaryotic promoters suitable in this regard are the CMV immediate early promoter, the HSV thymidine kinase promoter, the early and late SV40 promoters, the promoters of retroviral LTRs, such as those of the Rous sarcoma virus ("RSV"), and metallothionein promoters, such as the mouse metallothionein-I promoter.

Recombinant expression vectors will include, for example, origins of replication, a promoter preferably derived from a highly-expressed or regulatable gene to direct transcription of a downstream structural sequence, and a selectable marker to permit isolation of vector containing cells after exposure to the vector.

Polynucleotides of the invention, encoding the heterologous structural sequence of a polypeptide of the invention generally will be inserted into the vector using standard techniques so that it is operably linked to the promoter for expression. The polynucleotide will be positioned so that the transcription start site is located appropriately 5' to the AUG that initiates translation of the polypeptide to be expressed. Where applicable, a ribosome binding site may be located between the transcription start site and the initiating AUG. Generally, there will be no other open reading frames that begin with an initiation codon, usually AUG, and lie between the ribosome binding site, where applicable or the 5' end of the transcript and the initiation codon. Also, generally, there will be a translation stop codon at the end of the polypeptide and there will be a polyadenylation signal in constructs for use in eukaryotic hosts. Transcription termination signal appropriately disposed at the 3' end of the transcribed region may also be included in the polynucleotide construct.

For secretion of the translated protein into the lumen of the endoplasmic reticulum, into the periplasmic space or into the extracellular environment, appropriate secretion signals may be incorporated into the expressed polypeptide. These signals may be endogenous to the polypeptide or they may be heterologous signals.

The polypeptide may be expressed in a modified form, such as a fusion protein, and may include not only secretion signals but also additional heterologous functional regions. Thus, for instance, a region of additional amino acids, particularly charged amino acids, may be added to the N-or C-terminus of the polypeptide to improve stability and persistence in the host cell, during purification or during subsequent handling and storage. Also, a region may be added to the polypeptide to facilitate purification. Such regions may be removed prior to final preparation of the polypeptide. The addition of peptide moieties to polypeptides to engender secretion or excretion, to improve stability or to facilitate purification, among others, are familiar and routine techniques in the art. A preferred fusion protein comprises a heterologous region from immunoglobulin that is useful to solubilize or purify polypeptides. For example, EP-A-0 464 533 (Canadian counterpart 2045869) discloses fusion proteins comprising various portions of constant region of immunoglobulin molecules together with another protein or part thereof. In drug discovery, for example, proteins have been fused with antibody Fc portions for the purpose of high-throughput screening assays to identify antagonists. See, D. Bennett et ah, Journal of Molecular Recognition, 8: 52-58 (1995) and K. Johanson et ah, The Journal of Biological Chemistry, 270,(16): 9459-9471 (1995).

Cells typically then are harvested by centrifugation, disrupted by physical or chemical means, and the resulting crude extract retained for further purification. Microbial cells employed in expression of proteins can be disrupted by any convenient method, including freeze-thaw cycling, sonication, mechanical disruption, or use of cell lysing agents, such methods are well know to those skilled in the art.

Mammalian expression vectors may comprise an origin of replication, a suitable promoter and enhancer, and also any necessary polyadenylation sites, splice donor and acceptor sites, transcriptional termination sequences, and 5' flanking non-transcribed sequences that are necessary for expression. In certain preferred embodiments in this regard DNA sequences derived from the SV40 splice sites, and the SV40 polyadenylation sites are used for required non-transcribed genetic elements of these types.

HSV-2 polypeptides can be recovered and purified from recombinant cell cultures by well-known methods including ammonium sulfate or ethanol precipitation, acid extraction, anion or cation exchange chromatography, phosphocellulose chromatography, hydrophobic interaction chromatography, affinity chromatography, hydroxylapatite chromatography and lectin chromatography. Most preferably, high performance liquid chromatography ("HPLC") is employed for purification. Well known techniques for refolding protein may be employed to regenerate active conformation when the polypeptide is denatured during isolation and or purification.

Polypeptides of the present invention include naturally purified products, products of chemical synthetic procedures, and products produced by recombinant techniques from a prokaryotic or eukaryotic host, including, for example, viral, yeast, higher plant, insect and mammalian cells. Depending upon the host employed in a recombinant production procedure, the polypeptides of the present invention may be glycosylated or may be non-glycosylated. In addition, polypeptides of the invention may also include an initial modified methionine residue, in some cases as a result of host-mediated processes.

HSV-2 polynucleotides and polypeptides may be used in accordance with the present invention for a variety of applications, particularly those that make use of the chemical and biological properties of HSV-2. Additional applications relate to diagnosis and to treatment of disorders of cells, tissues and organisms. These aspects of the invention are illustrated further by the following discussion.

Polynucleotide assays: This invention is also related to the use of the HSV-2 polynucleotides to detect complementary polynucleotides such as, for example, as a diagnostic reagent. Detection of HSV- 2 polynucleotides in a eukaryote, particularly a mammal, and especially a human, will provide a diagnostic method that can add to, define or allow a diagnosis of a disease. Eukaryotes (herein also "individual(s)"), particularly mammals, and especially humans, infected by HSV-2 may be detected at the DNA or RNA level by a variety of techniques. Nucleic acids for diagnosis may be obtained from an individual's cells, tissues, and fluids, such as brain, bone, blood, muscle, cartilage, skin, saliva, urine, semen, and mucous. Tissue biopsy and autopsy material is also preferred for samples from an individual to use in a diagnostic assay. The viral DNA may be used directly for detection or may be amplified enzymatically by using PCR prior to analysis (Saiki et ah, Nature 324: 163-166 (1986)). RNA or cDNA may also be used in the same ways. As an example, PCR primers complementary to the nucleic acid encoding HSV-2 can be used to identify and analyze HSV-2 presence and expression. Using PCR, characterization of the strain of virus present in a eukaryote, particularly a mammal, and especially a human, may be made by an analysis of the genotype of the viral gene. For example, deletions and insertions can be detected by a change in size of the amplified product in comparison to the genotype of a reference sequence. Point mutations can be identified by hybridizing amplified DNA to radiolabeled HSV-2 RNA or alternatively, radiolabeled HSV-2 antisense DNA sequences. Perfectly matched sequences can be distinguished from mismatched duplexes by RNase A digestion or by differences in melting temperatures. Sequence differences between a reference gene and genes having mutations also may be revealed by direct DNA sequencing. In addition, cloned DNA segments may be employed as probes to detect specific DNA segments. The sensitivity of such methods can be greatly enhanced by appropriate use of PCR or another amplification method. For example, a sequencing primer is used with double-stranded PCR product or a single-stranded template molecule generated by a modified PCR. The sequence determination is performed by conventional procedures with radiolabeled nucleotide or by automatic sequencing procedures with fluorescent-tags.

Genetic typing of various strains of virus based on DNA sequence differences may be achieved by detection of alteration in electrophoretic mobility of DNA fragments in gels, with or without denaturing agents. Small sequence deletions and insertions can be visualized by high resolution gel electrophoresis. DNA fragments of different sequences may be distinguished on denaturing formamide gradient gels in which the mobilities of different DNA fragments are retarded in the gel at different positions according to their specific melting or partial melting temperatures (see, e.g., Myers et ah, Science. 230: 1242 (1985)). Sequence changes at specific locations also may be revealed by nuclease protection assays, such as RNase and S 1 protection or the chemical cleavage method (e.g. , Cotton et ah, Proc. Natl. Acad. Sci.. USA. 85: 4397-4401 (1985)).

Thus, the detection of a specific DNA sequence may be achieved by methods such as hybridization, RNase protection, chemical cleavage, direct DNA sequencing or the use of restriction enzymes, (e.g., restriction fragment length polymorphisms ("RFLP") and Southern blotting of genomic DNA.

In addition to more conventional gel-electrophoresis and DNA sequencing, mutations also can be detected by in situ analysis.

Cells carrying mutations or polymorphisms in the gene of the present invention may also be detected at the DNA level by a variety of techniques, to allow for serotyping, for example. Nucleic acids for diagnosis may be obtained from an infected individual's cells, including but not limited to blood, urine, saliva, tissue biopsy and autopsy material or from virus isolated and cultured from the above or other sources. The viral DNA may be used directly for detection or may be amplified enzymatically by using PCR (Saiki etal, Nature, 324:163-166 (1986)) prior to analysis. RT-PCR can also be used to detect mutations. It is particularly preferred to used RT-PCR in conjunction with automated detection systems, such as, for example, GeneScan. RNA or cDNA may also be used for the same purpose, PCR or RT-PCR. As an example, PCR primers complementary to the nucleic acid encoding HSV-2 can be used to identify and analyze mutations. For example, deletions and insertions can be detected by a change in size of the amplified product in comparison to the normal genotype. Point mutations can be identified by hybridizing amplified DNA to radiolabeled RNA or alternatively, radiolabeled antisense DNA sequences. Perfectly matched sequences can be distinguished from mismatched duplexes by RNase A digestion or by differences in melting temperatures. The primers may be used to amplify the gene isolated from the individual such that the gene may then be subject to various techniques for elucidation of the DNA sequence. In this way, mutations in the DNA sequence may be detected. Polypeptide assays:

The present invention also relates to diagnostic assays such as quantitative and diagnostic assays for detecting levels of HSV-2 protein in cells and tissues, including determination of normal and abnormal levels. Thus, for instance, a diagnostic assay in accordance with the invention for detecting expression of HSV-2 protein compared to normal control tissue samples may be used to detect the presence of an infection Assay techniques that can be used to determine levels of a protein, such as an HSV-2 protem of the present invention, in a sample deπved from a host are well-known to those of skill in the art Such assay methods include radioimmunoassays, competitive-binding assays, Western Blot analysis and ELISA assays Among these ELISAs frequently are preferred An ELISA assay initially compπses prepaπng an antibody specific to HSV-2, preferably a monoclonal antibody In addition a reporter antibody generally is prepared which binds to the monoclonal antibody The reporter antibody is attached to a detectable reagent such as radioactive, fluorescent or enzymatic reagent, in this example horseradish peroxidase enzyme Antibodies:

The polypeptides, their fragments or other deπvatives, or analogs thereof, or cells expressing them can be used as an immunogen to produce antibodies thereto The present invention includes, for examples monoclonal and polyclonal antibodies, chimenc, single chain, and humanized antibodies, as well as Fab fragments, or the product of an Fab expression library Antibodies generated against the polypeptides corresponding to a sequence of the present invention can be obtained by direct injection of the polypeptides into an animal or by administeπng the polypeptides to an animal, preferably a nonhuman The antibody so obtained will then bind the polypeptides itself In this manner, even a sequence encoding only a fragment of the polypeptides can be used to generate antibodies binding the whole native polypeptides Such antibodies can then be used to isolate the polypeptide from tissue expressing that polypeptide

For preparation of monoclonal antibodies, any technique known in the art which provides antibodies produced by continuous cell line cultures can be used Examples include vaπous techniques, such as those in Kohler, G and Milstein, C , Nature 256 495-497 (1975), Kozbor et al . Immunology Today 4 72 (1983), Cole et al, pg 7 '-96 m MONOCLONAL ANTIBODIES AND CANCER THERAPY, Alan R Liss, Inc (1985)

Techniques descnbed for the production of single chain antibodies (U S Patent No 4,946,778) can be adapted to produce single chain antibodies to immunogenic polypeptide products of this invention Also, transgenic mice, or other organisms such as other mammals, may be used to express humanized antibodies to immunogenic polypeptide products of this invention

Alternatively phage display technology could be utilized to select antibody genes with binding activities towards the polypeptide either from repertoires of PCR amplified v- genes of lymphocytes from humans screened for possessing anti-Fbp or from naive libraries (McCafferty, J. et ah, , Nature 348, 552-554 (1990); Marks, J. et aL, Biotechnology 10: 779-783 (1992). The affinity of these antibodies can also be improved by chain shuffling (Clackson, T. et aL, Nature 352, 624-628 (1991).

If two antigen binding domains are present each domain may be directed against a different epitope - termed 'bispecific' antibodies.

The above-described antibodies may be employed to isolate or to identify clones expressing the polypeptide or purify the polypeptide of the present invention by attachment of the antibody to a solid support for isolation and/or purification by affinity chromatography.

Thus among others, antibodies against HSV-2 may be employed to inhibit and or treat infections, particularly viral infections, and especially HSV-2 infections as well as to monitor the effectiveness of antibiotic treatment.

Polypeptide derivatives include antigenically, epitopically or immunologically equivalent derivatives which form a particular aspect of this invention. The term "antigenically equivalent derivative" as used herein encompasses a polypeptide or its equivalent which will be specifically recognized by certain antibodies which, when raised to the protein or polypeptide according to the present invention, interfere with the immediate physical interaction between pathogen and mammalian host. The term "immunologically equivalent derivative" as used herein encompasses a peptide or its equivalent which when used in a suitable formulation to raise antibodies in a vertebrate, the antibodies act to interfere with the immediate physical interaction between pathogen and mammalian host.

The polypeptide, such as an antigenically or immunologically equivalent derivative or a fusion protein thereof, is used as an antigen to immunize a mouse or other animal such as a rabbit, rat or chicken. The fusion protein may provide stability to the polypeptide. The antigen may be associated, for example by conjugation , with an immunogenic carrier protein for example bovine serum albumin (BSA) or keyhole limpet haemocyanin (KLH). Alternatively a multiple antigenic peptide comprising multiple copies of the protein or polypeptide, or an antigenically or immunologically equivalent polypeptide thereof may be sufficiently antigenic to improve immunogenicity so as to obviate the use of a carrier. Preferably the antibody or derivative thereof is modified to make it less immunogenic in the individual. For example, if the individual is human the antibody may most preferably be "humanised" ; where the complimentarity determining region(s) of the hybridoma-derived antibody has been transplanted into a human monoclonal antibody , for example as described in Jones, P. et a Nature 321 : 522-525 (1986)or Tempest et ah, Biotechnology 9: 266-273 (1991). The above antibody reagents will also be useful for assessing the biological role of the gene through antibody inhibition studies, immunoprecipitation studies, super-shift experiments and similar techniques. These studies may lead to discovery of novel proteimprotein interactions which may be useful drug targets. The above antibody reagents may lead to the identification of novel viral proteins not predicted by the DNA sequence, which in turn may be novel drug targets. HSV-2 binding molecules and assays:

This invention also provides a method for identification of molecules, such as binding molecules, that bind HSV-2. Genes encoding proteins that bind HSV-2, such as binding proteins, can be identified by numerous methods known to those of skill in the art, for example, ligand panning and FACS sorting. Such methods are described in many laboratory manuals such as, for instance, Coligan sϊ aL, Current Protocols in Immunology 1(2): Chapter 5 (1991).

For instance, expression cloning may be employed for this purpose. To this end polyadenylated RNA is prepared from a cell expressing HSV-2, a cDNA library is created from this RNA, the library is divided into pools and the pools are transfected individually into cells that are not expressing HSV-2. The transfected cells then are exposed to labeled HSV-2. HSV-2 can be labeled by a variety of well-known techniques including standard methods of radio- iodination or inclusion of a recognition site for a site-specific protein kinase. Following exposure, the cells are fixed and binding of HSV-2 is determined. These procedures conveniently are carried out on glass slides. Alternatively a labeled ligand can be photoaffinity linked to a cell extract, such as a membrane or a membrane extract, prepared from cells that express a molecule that it binds, such as a binding molecule. Cross-linked material is resolved by polyacrylamide gel electrophoresis ("PAGE") and exposed to X-ray film. The labeled complex containing the ligand-binding can be excised, resolved into peptide fragments, and subjected to protein microsequencing. The amino acid sequence obtained from microsequencing can be used to design unique or degenerate oligonucleotide probes to screen cDNA libraries to identify genes encoding the putative binding molecule.

Polypeptides of the invention also can be used to assess HSV-2 binding capacity of HSV-2 binding molecules in cells or in cell-free preparations. Polypeptides of the invention may also be used to assess the binding of small molecule substrates and ligands in, for example, cells, cell-free preparations, chemical libraries, and natural product mixtures. These substrates and ligands may be natural substrates and ligands or may be structural or functional mimetics.

This invention also provides a method of screening drugs to identify those which interfere with the proteins selected as targets herein, which method comprises measuring the interference of the activity of the protein by a test drug. For example if the protein selected has a catalytic activity, after suitable purification and formulation the activity of the enzyme can be followed by its ability to convert its natural substrates. By incorporating different chemically synthesised test compounds or natural products into such an assay of enzymatic activity one is able to detect those additives which compete with the natural substrate or otherwise inhibit enzymatic activity.

The invention also relates to activators and inhibitors identified thereby. Another aspect of the invention relates to use of a polynucleotide in genetic immunization, and will preferably employ a suitable delivery method such as direct injection of plasmid DNA into muscles (Wolff et al., Hum. Mol. Genet. 1:363 (1992); Manthorpe et al., Hum. Gene Ther. 4:419 (1963)), delivery of DNA complexed with specific protein carriers ( Wu et al., J. Biol. Chem. 264:16985 (1989)), coprecipitation of DNA with calcium phosphate (Benvenisty & Reshef, Proc. Nat'l Acad. Sci. USA. 83:9551 (1986)), encapsulation of DNA in various forms of liposomes (Kaneda et al., Science 243:375 (1989)), particle bombardment (Tang et al, Nature 356:152 (1992)); Eisenbraun et al., DNA Cell Biol. 12:791 (1993)) and in vivo infection using cloned retroviral vectors (Seeger et al., Proc. Nat'l. Acad. Sci. USA 81:5849 (1984)). Suitable promoters for muscle transfection include CMV, RSV, SRa, actin, MCK, alpha globin, adenovirus and dihydrofolate reductase. In therapy or as a prophylactic, the active agent i.e., the polypeptide, polynucleotide or inhibitor of the invention, may be administered to a patient as an injectable composition, for example as a sterile aqueous dispersion, preferably isotonic. Vaccines: Another aspect of the invention relates to a method for inducing an immunological response in an individual, particularly a mammal which comprises inoculating the individual with HSV-2 polypeptide, or an antigenic fragment or variant thereof, adequate to produce antibody to protect said individual from infection, particularly HSV-2 infection. Yet another aspect of the invention relates to a method of inducing immunological response in an individual which comprises, through gene therapy, delivering a gene encoding HSV-2, or an antigenic fragment or a variant thereof, for expressing HSV-2, or a fragment or a variant thereof in vivo in order to induce an immunological response to produce antibody to protect said individual from disease.

A further aspect of the invention relates to an immunological composition which, when introduced into a host capable or having induced within it an immunological response, induces an immunological response in such host to HSV-2 or a protein coded therefrom, wherein the composition compπses a recombinant HSV-2 or protein coded therefrom comprising DNA which codes for and expresses an antigen of said HSV-2 or protein coded therefrom.

The HSV-2 or a fragment thereof may be fused with a co-protein which may not by itself produce antibodies, but is capable of stabilizing the first protein and producing a fused protein which will have immunogenic and protective properties. This fused recombinant protein, preferably further comprises an antigenic co-protein, such as Glutathione-S- transferase (GST) or beta-galactosidase, relatively large co-proteins which solubilise the protein and facilitate production and purification thereof. Moreover, the co-protein may act as an adjuvant in the sense of providing a generalized stimulation of the immune system. The co-protein may be attached to either the amino or carboxy terminus of the first protein.

The present invention also includes a vaccine formulation which comprises the immunogenic recombinant protein together with a suitable carrier. Since the protein may be broken down in the stomach, it is preferably administered parenterally, including, for example, administration that is subcutaneous, intramuscular, intravenous, or intradermal. Formulations suitable for parenteral administration include aqueous and non-aqueous sterile injection solutions which may contain anti-oxidants, buffers, bacteriostats and solutes which render the formulation instonic with the bodily fluid, preferably the blood, of the individual; and aqueous and non-aqueous sterile suspensions which may include suspending agents or thickening agents. The formulations may be presented in unit-dose or multi-dose containers, for example, sealed ampoules and vials and may be stored in a freeze-dried condition requiring only the addition of the sterile liquid carrier immediately prior to use. The vaccine formulation may also include adjuvant systems for enhancing the immunogenicity of the formulation, such as oil-in water systems and other systems known in the art. The dosage will depend on the specific activity of the vaccine and can be readily determined by routine experimentation.

Whilst the invention has been described with reference to acertain HSV-2 polypeptide, it is to be understood that this covers fragments of the naturally occurring protein and similar proteins (for example, having sequence homologies of 75% or greater) with additions, deletions or substitutions which do not substantially affect the immunogenic properties of the recombinant protein. Compositions:

The invention also relates to compositions comprising the polynucleotide or the polypeptides discussed above or the inhibitors. Thus, the polypeptides of the present invention may be employed in combination with a non-sterile or sterile carrier or carriers for use with cells, tissues or organisms, such as a pharmaceutical carrier suitable for administration to a subject. Such compositions comprise, for instance, a media additive or a therapeutically effective amount of a polypeptide of the invention and a pharmaceutically acceptable carrier or excipient. Such carriers may include, but are not limited to, saline, buffered saline, dextrose, water, glycerol, ethanol and combinations thereof. The formulation should suit the mode of administration.

Kits:

The invention further relates to diagnostic and pharmaceutical packs and kits comprising one or more containers filled with one or more of the ingredients of the aforementioned compositions of the invention. Associated with such containers) can be a notice in the form prescribed by a governmental agency regulating the manufacture, use or sale of pharmaceuticals or biological products, reflecting approval by the agency of the manufacture, use or sale of the product for human administration.

Administration:

Polypeptides and other compounds of the present invention may be employed alone or in conjunction with other compounds, such as therapeutic compounds.

The pharmaceutical compositions may be administered in any effective, convenient manner including, for instance, administration by topical, oral, anal, vaginal, intravenous, intraperitoneal, intramuscular, subcutaneous, intranasal or intradermal routes among others.

The pharmaceutical compositions generally are administered in an amount effective for treatment or prophylaxis of a specific indication or indications. It will be appreciated that optimum dosage will be determined by standard methods for each treatment modality and indication, taking into account the indication, its severity, route of administration, complicating conditions and the like.

In therapy or as a prophylactic, the active agent may be administered to an individual as an injectable composition, for example as a sterile aqueous dispersion, preferably isotonic.

Alternatively the composition may be formulated for topical application for example in the form of ointments, creams, lotions, eye ointments, eye drops, ear drops, mouthwash, impregnated dressings and sutures and aerosols, and may contain appropriate conventional additives, including, for example, preservatives, solvents to assist drug penetration, and emollients in ointments and creams. Such topical formulations may also contain compatible conventional carriers, for example cream or ointment bases, and ethanol or oleyl alcohol for lotions. Such carriers may constitute from about 1% to about 98% by weight of the formulation; more usually they will constitute up to about 80% by weight of the formulation. For administration to mammals, and particularly humans, it is expected that the daily dosage level of the active agent will be from 0.01 mg/kg to 10 mg/kg, typically around 1 mg/kg. The physician in any event will determine the actual dosage which will be most suitable for an individual and will vary with the age, weight and response of the particular individual. The above dosages are exemplary of the average case. There can, of course, be individual instances where higher or lower dosage ranges are merited, and such are within the scope of this invention.

The composition of the invention may be administered by injection to achieve a systemic effect against relevant virus shortly before insertion of an in-dwelling device. Treatment may be continued after surgery during the in-body time of the device. In addition, the composition could also be used to broaden perioperative cover for any surgical technique to prevent viral reactivation.

Alternatively, the composition of the invention may be used to bathe an indwelling device immediately before insertion. A vaccine composition is conveniently in injectable form. Conventional adjuvants may be employed to enhance the immune response.

A suitable unit dose for vaccination is 0.5-5 microgram/kg of antigen, and such dose is preferably administered 1-3 times and with an interval of 1-3 weeks.

With the indicated dose range, no adverse toxicological effects will be observed with the compounds of the invention which would preclude their administration to suitable individuals.

In order to facilitate understanding of the following example certain frequently occurring methods and/or terms will be described.

Example 1 Preparation of ultra-purified Herpes simplex 2 virus DNA:

This protocol describes the preparation of herpes simplex virus type 2 strain SB5 DNA for sequencing. It is the combination of two protocols, both of which have been modified. Part one describes the crude isolation of the viral DNA from host cell DNA (Hirt, B., J. Mol. Biol. 26: 365-369. (1967),), and part two describes the ultra-purification of the viral DNA through a cesium chloride (CsCl) gradient (Vinograd J,et ah, Proc. Nat'l. Acad. Sci.(USA) 2:902-910(1963)).

I. Separation of viral DNA from host DNA (modified from Hirt^) Confluent monolayers of Vero cells (ATCC CCL 81) previously seeded into roller bottles (1 x 10⁸ cells/bottle), were infected with HSV-2 strain SB5 at an MOI = 0.01 in HBSS. After one hour, the virus innoculum was removed and normal media was added (DMEM, 10% FCS).

Approximately 40-48 hours post- infection, infected monolayers were harvested by scraping, and placed in 10ml of cold lx PBS. For subsequent steps, three roller bottles of infected cells were combined (3 x 10° cells) The cells were spun at 2000g x 5 minutes. The supernatant was removed and to the cell pellet, 25ml of DNA extraction buffer was added (0.25% Triton X-100, lOmM EDTA, lOmM Tris pH 8.0).

The lysate was mixed at room temperature for 10 minutes. Them to the lysate, 1ml of 5M NaCl (0.2M final concentration) was added and allowed to mix another 15 minutes. The lysate was centrifuged at 10,000g for 30 minutes at 4°C. The supernatant, which contains the viral DNA, was saved and the pellet, which contains mostly chromosomal DNA, was discarded.

To the supernatant, SDS was added to 0.5% final cone, and Proteinase K to 150ug/ml final cone. This was incubated 2 hours at 45°C. After two hours, 2.5 volumes of 100% ethanol were added. Viral DNA was precipitated overnight at -20°C.

The precipitate was centrifuged at 10,000g for 30 minutes at 4°C. The pellet was washed once with 70% ethanol and air dried for 30 minutes. Then the pellet was resuspended in 250ul of TE (lOmM Tris, pH 7.5, 2mM EDTA). RNase A was added to a final concentration of lOug/ml and incubated at 37 °C for one hour.

SDS and Proteinase K were then added (as above) and incubated overnight at 37°C.

The DNA was phenol extracted 2x, chloroform extracted lx, and 1/10 volume 3M sodium acetate and 2.5 volumes of 100% ethanol to precipitate were added and allowed to precipitate overnight at -20°C. The next day, The precipitate was spun down at 15,000g x 20 minutes. The pellet was washed lx with 70% ethanol, briefly air dried and resuspended in 1ml of TE.

II. Ultrapurification of the viral DNA through a CsCl gradient (modified from Vinograd, et al. supra) A cesium chloride solution of 57% w/w with the prepared DNA from above was made as follows:

To the 1 ml of viral DNA prepared above, 9ml of TE was added for a total of exactly 10ml. To this, 13.26g of CsCl was added and dissolved. This solution was added to ultracentrufuge tubes and spun in a VTi 40 rotor at 35,000 rpm for 72 hours at 25°C. After centrifugation, the tube was mounted on a gradient collector and through a hole pierced in the bottom, 15 drop fractions were collected.

The refractive index of every fourth tube was determined on a refractometer. The viral DNA lies between refractive indicies = 1.403-1.401. Density range for HSV DNA from Goldin A , et ah, J. Virol. : 50-58. Boyant density (p) = a η²⁵ - b , where coefficients a and b are 10.8601 and 13.4974 respectively for CsCl, η = refractive index. (Isco tables, a handbook of data for biological and physical scientist, Isco, Inc. Lincoln, NE, ninth ed. 1987).

The appropriate fractions were pooled and dialyzed against 3L of TE with frequent changing overnight.

The final DNA prep was concentrated by precipitating with 1/10 volume 3M sodium acetate and 2.5 volumes of 100% ethanol. The DNA was resuspended in TE and the OD ₂60/280 ^reading taken.

The DNA was then subjected to sequencing as provided in Sambrook, J et al. (1989) Chapter 13, supra: or by automated DNA sequencing as per manufacturer's protocols, e.g., Applied Biosystems/Perkin Elmer, Foster City, CA.

Certain preferred individual polynucleotide and polypeptide sequences of the invention are summarized in the following Tables. Tables 1, 2 and 3 represent three different sequencing efforts. Table 4 represents polypeptides encoded by ORFs from Table 3.

Table 1 provides polynucleotides of the invention and polypeptides encoded by ORFs, wherein the polynucleotide start and end position for each ORF is indicated by sequence numbers which correlate to the the polynucleotide sequence referred to above each given polypeptide in the Table. Additionally, each ORF-encoded polypeptide sequence is labeled with the Contig number matching the Contig number of the polynucleotide sequence from which it was encoded. For ORF sequences wherein the start polynucleotide number is larger than the end polynucleotide number, translation of that polypeptide initiates on the nucleotide strand which is complemetary to the strand depicted in the Table. In many cases there is more than one ORF mapped to an individual Contig. Contig assembly was performed using the publicly-available Phrap program, P.Green, University of Washington, WA., U.S.A. ORF prediction was accomplised using the publicly-available GenMark program, Georgia Tech Research Corp., Georgia Tech, GA, U.S.A. Homologies of the polypeptide sequences to known proteins are also indicted. These homologies were determined using the public database Mpsrch_pp, release 2.1 by J.Collins, Biocomputing Research Unit, University of Edinburgh (distributed by IntelliGenetics, Inc.). Table 2, obtained from a separately-performed sequencing, provides polynucleotides of the invention and polypeptides encoded by ORFs, wherein the polynucleotide start and end position for ORFs are indicated by sequence numbers which correlate to the polynucleotide sequence referred to above each given polypeptide in the Table. Each ORF-encoded polypeptide sequence is labeled with a Contig number matching the Contig number of the polynucleotide sequence referred to above it, from which it was encoded. For ORF sequences wherein the nucleotide start number is larger than the end number, translation of that polypeptide initiates on the nucleotide strand which is complementary to the strand depicted in the Table. Contig assembly was accomplished using the publicly-available Sequencher 3.0, Gene Codes Corp., Ann Arbor MI, USA, software program. ORF prediction was done using the publicly-available GenMark program (see Table 1). Homologies of the polypeptide sequences to known proteins are indicated. These homologies were determined using the publicly-available Mpsrch program (see Table

1).

Table 3 obtained from a separately-performed sequencing, provides polynucleotides of the invention and polypeptides encoded by ORFs, wherein the polynucleotide start and end positions for each ORF is indicated by sequence numbers which correlate to the polynucleotide sequence referred to above that polypeptide in the

Table. Each ORF-encoded polypeptide sequence is labeled with a Contig number matching the Contig number of the polynucleotide sequence appearing above it from which it was encoded. For ORF sequences wherein the start polynucleotide number is larger than the end number, translation of that polypeptide initiates on the nucleotide strand which is complementary to the strand depicted in the Table. Contig assembly was performed using the publicly-available Phrap program, (see Table 1). ORF prediction was accomplished using the publicly-available GenMark software program (see Table 1). Homologies of the polypeptide sequences to known proteins are indicated. These homologies were determined by comparison with public database Mpsrch_pp (see Table 1). Table 4 provides ORF sequences of polypeptides encoded by the polynucleotide sequences of Table 3 which were predicted by the GenMark program (see Table 1) as having more than a single start site (N-terminal methionyl residue). The Contig numbers and polynucleotide start and end sites for these ORFs correlate to the Contig numbers and polynucleotide sequence numbers of Table 3. TABLE 1

[SEQ ID NO:l] = Contig ID 100

[SEQ ID NO: 2]

ORF # = 1 from Contig ID 100

ORF start site = 1808 ORF end site = 3 ORF sequence : VLMGRLRNAPESLTYMFCAAIRVAPVTTQSRTSLRVCTHVLFPDPALPVMRYAANGNSR SGRPVGTSKAATSRNHCRRGTCVTSSCCCESSRMRAMIGWTPCMDVKFKNASSLNRTAGL APGCCGGGPGARTSREPSPPDAAMAAQRARAPAMRTRGGDAALCAPEDG VKVHPTPGT LFREILLGQMGYTEGQGVYNWRSSEAATRQLQAAIFHALLNATTYRDLEEDWRRHWAR GLQPQRLVRRYRNAREGDIAGVAERVFDTWRCTLRTTLLDFAHGWNCFAPGGPSGPTSF PKYIDWLTCLGLVPILRKTREGEATQRLGAFLRQHTLPRQLATVAGAAERAGPGLLELAV AFDSTRMAEYDRVHIYYNHRRGE LVRDPVSGQRGECLVLCPPLWTGDRLVFDSPVQRLC PEIVACHALREHAHICRLRNTASVKVLLGRKSDSERGVAGAARWNKALGEDDETKAGSA ASCLVRLIINMKGMRHVGDINDTVRAYLDEAGGHLIDTPAVDHTLPGFGKGGTGRGSAAQ DPGARPQQLRQAFQTAWNNINGMLEGYINNLFGTIERLRETNAGLATQLQARGGSSRST AX

Gene matched: gi | 136794 | sp | P10190 |UL06_HSV11 Gene name: VIRION PROTEIN U 6. gi | 73994

[SEQ ID NO: 3]

ORF # = 2 from Contig 100 ORF start site = 1378 ORF end site = 4023 ORF sequence: MAASGGEGSRDVRAPGPPPQQPGARPAVRFRDEAFLNFTSMHGVQPIIARIRELSQQQLD VTQVPRLQWFRDVAALEVPTGLPLREFPFAAYLITGNAGSGKSTCVQTLNEVLDCWTGA TRIAAQNMYVKLSGAFLSRPINTIFHEFGFRGNHVQAQLGQHPYTLASSPASLEDLQRRD LTYYWEVILDITKRALAAHGGEDARNEFHALTALEQTLGLGQGALTRLASVTHGALPAFT RSNIIVIDEAGLLGRHLLTTWYCWWMINALYHTPQYAGRLRPVLVCVGSPTQTAΞLEST FEHQKLRCSVRQSENVLTYLICNRTLREYTRLSHSWAIFINNKRCVEHEFGNLMKVLEYG LPITEEHMQFVDRFWPESYITNPANLPGWTRLFSSHKEVSAYMAKLHAYLKVTREGEFV VFTLPVLTFVSVKEFDKYRRLTQQPTLTMEK ITANASRITNYΞQSQDQDAGHVRCEVHS KQQLWARNDITYVLNSQVAVTARLRKMVFGFDGTFRTFEAVLRDDSFVKTQGETSVEFA YRFLSRLMFGGLIHFYNFLQRPGLDATQRTLAYGRLGELTAELLSLRRDAAGASATRAAD TSDRSPGERAFNFKHLGPRDGGPDDFPDDDLDVIFAGLDEQQLDVFYCHYALEEPETTAA VHAQFGLLKRAFLGRYLILRELFGEVFESAPFSTYVDNVIFRGCELLTGSPRGGLMSVAL QTDNYTLMGYTYTRVFAFAEELRRRHATAGVAEFLEESPLPYIVLRDQHGFMSWNTNIΞ EFVESIDSTELAMAINADYGISSKLAMTITRSQGLΞLDKVAICFTPGNLRLNSAYVAMSR TTSSEFLH NLNPLRERHERDDVISEHILSALRDPNWIVY*

Gene matched: gi | 74000 |pir | | MBEU5

Gene name : gene UL5 protein - human herpesvirus 1

[ SEQ ID NO : 4 ]

ORF # = 3 from Contig 100 ORF start site = 4090 ORF end site = 4695 ORF sequence :

MGNPQTTIAYSLHHPRAΞLTSALPDAAQWHVFESGTRAVLTRGRARQDRLPRGGWIQH TPIGLLVIIDCRAEFCAYRFIGRASTQRLER WDAHMYAYPFDSWVSSSHGESVRSATAG ILTWWTPDTIYITATIYGTAPEAARGCDNAPLDVRPTTPPAPVSPTAGEFPANTTDLLV EVLREIQISPTLDDADPTPGT*

Gene matched: gi | 136788 | sp | P28280 | UL04_HSV2H Gene name: PROTEIN UL4. gi | 73890 | pir | | W

[SEQ ID NO: 5]

ORF # = 4 from Contig 100

ORF start site = 5413

ORF end site = 4895

ORF sequence : VGPLDGEPDRDAISPLTSSVAGDPPGADGPYVTFDTLFMVSSIDELGRRQLTDTIRKDLR

LSLAKFΞIACTKTSSFSGTAARQRKRGAPPQRTCVPRSNKSLQMFVLCKRANAAQVREQL

RAVIRSRKPRKYYTRSSDGRLCPAVPVFVHEFVSSEPMRLHRDNVMLSTEPD*

Gene matched: gi | 330308

Gene name: (L02638) nuclear phosphoprotein [Herpes simplex v

[SEQ ID NO: 6]

ORF # = 5 from Contig 100 ORF start site = 6656

ORF end site = 5652

ORF sequence:

MKRARSRSPSPPSRPSSPFRTPPHGGSPRREVGAGILA.SDATSHVCIASHPGSGAGYPTR

LAAGSAVQRRRPRGCPPGVMFSASTTPEQPLGLSGDATPPLPTSVPLDWAAFRRAFLIDD AWRPLLEPELANPLTARLLAEYDRRCQTEEVLPPREDVFSWTRYCTPDDVRWIIGQDPY HHPGQAHGLAFSVRADVPVPPSLRNVLAAVKNCYPDARMΞGRGCLEKWARDGVLLLNTTL TVKRGAAASHSKLGWDRFVGGVVRRLAARRPGLVFML GAHAQNAIRPDPRQHYVLKFΞH PSPLSKVPFGTCQHFLAANRYLETRDIMPID SV*

Gene matched: gi | 330306

Gene name: (M25410) uracil-DNA glycosylase [Herpes simplex v

[SEQ ID NO: 7]

ORF # = 6 from Contig 100 ORF start site = 7080 ORF end site = 6529 ORF sequence:

VPCMRTPADDVSWRYEAPSVIDYARIDGIFLRYHCPGLDTFLWDRHAQRAYLVNPFLFAG GFLEDLSHSVFPADTQETTTRRALYKEIRDALGSRKQAVSHAPVRAGCVNFDYSRTRRCV GRRDLRPANTTST EPPVSSDDEASSQSKPLATQPPVLALSNAPPRRVSPTRGRRRHTRL RRN*

Gene matched: gi | 136776 | sp | P28278 | UL01_HSV2H Gene name: GLYCOPROTEIN L PRECURSOR, gi

[SEQ ID NO: 8] = Contig ID 101

[SEQ ID NO: 9] ORF # = 1 from Contig 101

ORF start site = 351

ORF end site = 1259

ORF sequence : IRRRGNVEIRVYYESVRPSRSRSHLKPSDHQEFPGHHVSPGSPGFPESPGNREFHDLPE NPGSRAYPGTRDPHDPHGCPGSLDPHGNPAQPAGLPSPVPYAPLGSPDPSSPRQRTYVLP

RVGIRNAPASDTRAPKRAHSRHRADRPPESPGSELYPLNAQALAHLQMLPADHRAFFRTV

IEVSRLCALNTHDPPPPLAGARVGQEAQLVHTQWLRANRESSPLWP RTAAMNFIAAAAP

CVQTHRHMHDLLMACAF CCLAHASTCSYAGLYSAHCQHLFRAFGCGPPVLTTSRGQGG

CN*

Gene matched: gi | 757866

Gene name: (X02138) 34K (UslO) (aa 1-284) [Human herpesvirus

[SEQ ID NO: 10] ORF # = 2 from Contig 101

ORF start site = 2140

ORF end site = 1871

ORF sequence:

MTSRPADQDSVRSSASVPLYPAASPVPAEAYYSESEDEAANDFLVR GRQQSVLRRRRRR

TRCVGLVIACLWALLSGGFGALLV LLR*

Gene matched: gi | 135568 | sp | P06481 |TEGP_HSV11 Gene name: TEGUMENT PHOSPHOPROTEIN US9

[SEQ ID NO: 11] ORF # = 3 from Contig 101 ORF start site = 2377 ORF end site = 2240 ORF sequence : VALHAVDAPSQFWWLAWWLRGAVGLGAVLCGIAFYVTSIARGA¹'

Gene matched: gi | 477669 |pir | | B45696 Gene name: 23-29K immunoreactive epitope dispens [SEQ ID NO: 12] ORF # = 4 from Contig 101 ORF start site = 3572 ORF end site = 2529 ORF sequence:

VAPPRHHRVIPEVSHVRGVTVHME PEAIMFAPGETFETKVSIHAVAHDDGPYAMDWM RFDVPSSCAEMRIYEACLYHPQLPECLSPADAPCAVSSWAYRLAVRSYAGCSRTTPPPRC FAEARMEPVPGLAWLASTVNLEFQHASPQHAGLYLCWYVDDHIHAWGHMTISTAAQYRN AWEQHLPQRQPEPVEPTRPHVRAPPPAPSARGPLRLGAVLGAALLLAALGLSAWACMTC RRRS RAVKSRASATGPTYIRVADSELYADWSSDSEGERDGSLWQDPPERPDSPSTNGS GFEILSPTAPSVYPHSEGRKSRRPLTTFGSGSPGRRHSQASYSSVLW*

Gene matched: gi | 138240 | sp | P04488 |VGLE_HSV11 Gene name: GLYCOPROTEIN E PRECURSOR, gi

[SEQ ID NO: 13]

ORF # = 5 from Contig 101

ORF start site = 4176

ORF end site = 3460

ORF sequence : MARGAGLVFFVGVWWSCLAAAPRTS KRVTSGEDWLLPAPAGPEERTRAHKLL AAEP LDACGPLRPSWVAL PPRRVLETWDAACMRAPEPLAIAYSPPFPAGDEGLYSELA RDR VAWNESLVIYGALETDSGLYTLSWGLSDEARQVASWLWEPAPVPTPTPDDYDEEDD AGVSERTPVSVPPPTPPRWSPRGPPEAPSCYPRGVPRARGNGPYGDPGGHYVCPRGDV*

Gene matched: gi | 138241 | sp | P13289 |VGLE_HSV2 Gene name: GLYCOPROTEIN E PRECURSOR, gi I

[SEQ ID NO: 14] ORF # = 6 from Contig 101

ORF start site = 5796

ORF end site = 4495

ORF sequence:

VYL ARVGGWLGYLGGTWTPHKGSLEGGKLGQFIGRERGARTAVPTISHRAHSHLDPSDP GMPGRSLQGLAILGLWVCATGLWRGPTVSLVSDSLVDAGAVGPQGFVEEDLRVFGELHF

VGAQVPHTNYYDGIIELFHYPLGNHCPRWHWTLTACPRRPAVAFTLCRSTHHAHSPAY

PTLELGLARQPLLRWTATRDYAGLYVLRVWVGSATNASLFVLGVALSANGTFVYNGSDY

GSCDPAQLPFSAPRLGPSSVYTPGASRPTPPRTTTSPSSPRDPTPAPGDTGTPAPASGER

APPNSTRSASESRHRLTVAQVIQIAIPASIIAFVFLGSCICFIHRCQRRYRRPRGQIYNP GGVSCAVNEAAMARLGAELRSHPNTPPKPRRRSSSSTTMPSLTSIAEESEPGPWLLSVS

PRPRSGPTAPQEV*

Gene matched: gi | 138328 | sp | P06764 |VGLI_HSV23 Gene name: GLYCOPROTEIN I. gi | 73722 |pir

[SEQ ID NO:15] ORF # = 7 from Contig 101 ORF start site = 7017 ORF end site = 5815 ORF sequence : VCIAYHGMGRLTSGVGTAALLWAVGLRWCAKYALADPSLKMADPNRFRGKNLPVLDQL TDPPGVKRVYHIQPSLEDPFQPPSIPITVYYAVLERACRSVLLHAPSEAPQIVRGASDEA RKHTYNLTIA YRMGDNCAIPITVMEYTECPYNKSLGVCPIRTQPR SYYDSFSAVSEDN LGFLMHAPAFETAGTYLRLVKINDWTEITQFILEHRARASCKYALPLRIPPAACLTSKAY QQGVTVDSIGMLPRFIPENQRTVALYSLKIAGWHGPKPPYTSTLLPPELSDTTNATQPEL VPEDPEDSALLEDPAGTVSSQIPPNWHIPSIQDVAPHHAPAAPSNPGLIIGALAGSTLAV LVIGGIAF VRRRAQMAPKRLRLPHIRDDDAPPSHQPLFY*

Gene matched: gi | 419141 |pir| | E43674

Gene name: US6 protein - human herpesvirus 2 (st [SEQ ID NO: 16]

ORF # = 8 from Contig 101

ORF start site = 7553

ORF end site = 7440

ORF sequence :

VGGLCLMILGMACLLEVLRRLGRELARCCPHAGQFAP*

Gene matched: gi | 137132 | sp | P13293 |VGLJ_HSV2 Gene name: GLYCOPROTEIN J. gi I 419140 Ipir

[SEQ ID NO: 17] = Contig ID 102

[SEQ ID NO: 18]

ORF # = 1 from Contig 102

ORF start site = 1502 ORF end site = 465 ORF sequence :

VCPPPPTNMAWCGSGLRLRPFHPPSPSFFVLRALIRAGPGPFAASPRAPSGPGCGMCRG DSPGVAGGSGEHCLGGDDGDDGRPRLACVGAIARGFAHLWLQATTLGFVGSWLSRGPYA DAMSGAFVIGSTGLGFLRAPPAFARPPTRVCA LRLVGGGAAVAL SLGEAGAPPGVPGP ATQCLALGAAYAALLVLADDVHPLFLLAPRPLFVGTLGVWGGLTIGGSARY WIDPRAA AALTAAWAGLGTTAAGDSFSKACPRHRRFCWSAVESPPPRYAPEDAERPTDHGPLLPS THHQRS PRVCGDGAARPENI WVPWTFAGALALAACAARGWWERS *

Gene matched : gi | 136909 | sp | P10227 | UL43_HSV11 Gene name : MEMBRANE PROTEIN UL43 . gi | 73

[ SEQ ID NO : 19 ]

ORF # = 2 from Contig 102 ORF start site = 2996 ORF end site = 1584 ORF sequence:

MAHLPGGAAAAPLSEDAIPSPRERTEDWPPCQIVLQGAELNGILQAFAPLRTSLLDSLLV VGDRGILVHNAIFGEQVFLPLDHSQFSRYR GGPTAAFLSLVDQKRSLLSVFRANQYPDL RRVELTVTGQAPFRTLVQRIWTTASDGEAVELASETLMKRELTSFAVLLPQGDPDVQLRL TKPQLTKWNAVGDETAKPTTFELGPNGKFSVFNARTCVTFAAREEGASSSTSAQVQILT SALKKAGQAAANAKTVYGENTHRTFSVWDDCSMRAVLRRLQVGGGTLNFFLTADVPSVC VTATGPNAVSAVFLLKPQRVCLN LGRTPGSSTGSLASQDSRAGPTDSQDFSSEPDAGDR GAPEEEGLEGQARVPPAFPEPPGTKRRHAGAEWPADDATKRPKTGVPAAPTRAESPPLS ARYGPEAAEGGGDGGRYAWYFRDLQTGDASPSPLSAFRGPQRPPYGFGLP* Gene matched: gi | 136905 | sp | P10226 |VPAP_HSV11 Gene name: POLYMERASE ACCESSORY PROTEIN

[SEQ ID NO: 20]

ORF # = 3 from Contig 102

ORF start site = 3490 ORF end site = 4152

ORF sequence:

MGLFGMMKFAQTHHLVKRRGLRAPEGYFTPIAVDL NVMYTLWKYQRRYPSYDREAITL

HCLCSMLRVFTQKSLFPIFVTDRGVECTEPWFGAKAILARTTAQCRTDEEASDVDASPP

PFPHHRLQAQFPPFQHAPPRARLRPGGPGERGPPAQARRPPGARPRSRPCAWLTCSVSAF CGR GTPTSTRVSWRPTTPARTSIIPTRSRTCIPRIPISC*

Gene matched: gi | 549322 | sp| P36699 |VHS_HSV2G Gene name: VIRION HOST SHUTOFF PROTEIN.

[SEQ ID NO: 21]

ORF # = 4 from Contig 102

ORF start site = 4122 ORF end site = 4970

ORF sequence :

VHTTDTDLLLMGCDIVLDISTGYIPTIHCRDLLQYFKMSYPQFLALFVRCHTDLHPNNTY

ASVEDVLRECHWTAPSRSQARRGARRERANSRSLESMPTLTAAPVGLETRISWTEILAQQ

IAGEDDYEEDPPLQPPDVAGGPRDGARSSSSEILTPPELVQVPNAQRVAEHRGYVAGRRR HVIHDAPEALDWLPDPMTIAELVEHRYVKYVISLISPKERGPWTLLKRLPIYQDLRDEDL

ARSIVTRHITAPDIADRFLAQLWAHAPPPAFYKDVLAKF DE*

Gene matched: gi | 549322 | sp| P36699 |VHS_HSV2G Gene name: VIRION HOST SHUTOFF PROTEIN.

[SEQ ID NO:22]

ORF # = 5 from Contig 102

ORF start site = 6266 ORF end site = 5253 ORF sequence:

MDPAVSPASTDPLDTHASGAGAAPIPVCPTPERYFYTSQCPDINHLRSLSILNR LETEL VFVGDEEDVSKLSEGELGFYRFLFAFLSAADDLVTENLGGLSGLFEQKDILHYYVEQECI EWHSRVYNIIQLVLFHNNDQARRAYVARTINHPAIRVKVDWLEARVRECDSIPEKFILM ILIEGVFFAASFAAIAYLRTNNLLRVTCQSNDLISRDEAVHTTASCYIYNNYLGGHAKPE AARVYRLFREAVDIEIGFIRSQAPTDSSILSPGALAAIENYVRFSADRLLGLIHMQPLYS APAPDASFPLSLMSTDKHTNFFECRSTSYAGAWNDL*

Gene matched: gi | 132624 | sp| P03174 |RIR2_HSV23 Gene name: RIBONUCLEOSIDE-DIPHOSPHATE R

[SEQ ID NO: 23] ORF # = 6 from Contig 102 ORF start site = 9861 ORF end site = 6319 ORF sequence : VIRRPVRPFGRTAHPASHGPAAVSVHRVRATVTLVPMANRPAASALAGARSPSERQEPRE PEVAPPGGDHVFCRKVSGVMVLSSDPPGPAAYRISDSSFVQCGSNCSMIIDGDVARGHLR DLEGATSTGAFVAISNVAAGGDGRTAWALGGTSGPSATTSVGTQTSGEFLHGNPRTPEP QGPQAVPPPPPPPFP GHECCARRDARGGAEKDVGAAESWΞDGPSSDSETEDSDSSDEDT GSGSETLSRSSSI AAGATDDDDSDSDSRSDDSVQPDVWRRRWSDGPAPVAFPKPRRPG DSPGNPGLGAGTGPGSATDPRASADSDSAAHAAAPQAEVAPVLDSQPTVGTDPGYPVPLE LTPENAEAVARFLGDAVDREPALMLEYFCRCAREESKRVPPRTFGSAPRLTEDDFGLLNY ALAEMRRLCLDLPPVPPNAYTPYHLREYATRLVNGFKPLVRRSARLYRILGILVHLRIRT REASFEEWMRSKEVDLDFGLTERLREHEAQLMILAQALNPYDCLIHSTPNTLVERGLQSA LKYEEFYLKRFGGHYMESVFQMYTRIAGFLACRATRGMRHIALGRQGS WEMFKFFFHRL YDHQIVPSTPAMLNLGTRNYYTSSCYLVNPQATTNQATLRAITGNVSAILARNGGIGLCM QAFNDASPGTASIMPALKVLDSLVAAHNKQSTRPTGACVYLEPWHSDVRAVLRMKGVLAG EEAQRCDNIFSALWMPDLFFKRLIRHLDGEENVTWSLFDRDTSMSLADFHGEEFEKLYEH LEAMGFGETIPIQDLAYAIVRSAATTGSPFIMFKDAVNRHYIYNTQGAAIAGSNLCTEIV HPSSKRSSGVCNLGSVNLARCVSRRTFDFGMLRDAVQACVLMVNIMIDSTLQPTPQCARG HDNLRSMGIGMQGLHTACLKMGLDLESAEFRDLNTHIAEVMLLAAMKTSNALCVRGARPF SHFKRSMYRAGRFHWERFSNASPRYEGEWEMLRQSMMKHGLRNSQFIALMPTAASAQIΞD VSEGFAPLFTNLFSKVTRDGETLRPNTLLLKELERTFGGKRLLDAMDGLEAKQWSVAQAL PCLDPAHPLRRFKTAFDYDQELLIDLCADRAPYVDHSQSMTLYVTEKADGTLPASTLVRL LVHAYKRGL TGMYYCKVRKATNΞGVFAGDDNIVCTSCAL*

Gene matched: gi | 330199

Gene name: (M12700) ribonucleotide reductase large subunit (

[SEQ ID NO: 24] ORF # = 7 from Contig 102 ORF start site = 11144 ORF end site = 10323 ORF sequence: VRRRLRCARRRRGGPGPHHDQLRRDAGRGAAGPVFRMPARHGPHARVSPRGHAVFRGASV WTQDELASVTAVCSGPQEATHTGHPGRPCSAVTIPACAFVDLDAELCLGGPGAAFLYLV FTYRQCRDQELCCVYWKSQLPPRGLEAALERLFGRLRITNTIHGAEDMTPLPPNRNVDF PLAVLAASSQSPRCSASQVTNPQFVDRLYRWQPDLRGRPTARTCTYAAFAELGVMPDNSP RCLHRTERFGAVGVPWILEGWWRPGG RACA*

Gene matched : gi | 139176 | sp | P22486 | VP19_HSV2G Gene name : CAPSID ASSEMBLY AND DNA MATU

[SEQ ID NO:25] ORF # = 8 from Contig 102 ORF start site = 11722 ORF end site = 10667 ORF sequence:

MKTKPLPTAPMA AESAVETTTSPRELAGHAPLRRVLRPPIARRDGPVLLGDRAPRRTAS TM LLGIDPAESSPGTRATRDDTEQAVDKILRGARRAGGLTVPGAPRYHLTRQVTLTDLC QPNAERAGALLLALRHPTDLPHLARHRAPPGRQTERLAEAWGQLLEASALGSGRAESGCA RAGLVSFNFLVAACAAAYDARDAAEAVRAHITTNYGGTRAGARLDRFSECLRAMVHTHVF PHEVMRFFGGLVSWSHRTS LASPPSAADPRRPHTPATRAGPVRPLPSRPAPL TWTPSC A GALGRRSCTWFSPTDSAGTRSSVACTWSRASSPRAD RRPSSGCSGASG*

Gene matched: gi | 139176 | sp | P22486 |VP19_HSV2G Gene name: CAPSID ASSEMBLY AND DNA MATU

[SEQ ID NO:26] = Contig ID 103

[SEQ ID NO: 27]

ORF # = 1 from Contig 102 ORF start site = 3308 ORF end site = 693 ORF sequence : MAETMNVATCTHQTHHAARAPGATSAPGAASGDPLGARRPIGDDECEQYTSSVSLARMLY GGDLAE VPRVHPKTTIERQQHGPVTFPDASAPTARCVTWRAPMGSGKTTALIRWLGEA IHSPDTSVLWSCRRSFTQTLATRFAESGLPDFVTYFSSTNYIMNDRPFHRLIVQVESLH RVGPNLLNNYDVLVLDEVMSTLGQLYSPTMQQLGRVDALMLRLLRTCPRIIAMDATANAQ LVDFLCSLRGEKNVHWIGEYAMPGFSARRCLFLPRLGPEVLQAALRPPGPAGGAPPPDA PPDATFFGEVEARLAGGDNVCIFLSTVSFAEWARFCRQFTDRVLLLHSLTPPGEVTTWG RYRWIYTTWTVGLSFDPPHFDSMFAYVKPMNYGPDMVSVYQSLGRVRTLRKGELLIYM DGSGARSEPVFTPMLLNHWSASGQWPAQFSQVTNLLCRRFKGRCDASHADAAQARGSRI YSKFRYKHYFERCTLACLADSLNILHMLLTLNCMHVRFWGHDAALTPRNFCLFLRGIHFD ALRAQRDLRELRCQDPDTSLSAQAAETEEVGLFVEKYLRPDVAPAEWALMRGLNSLVGR TRFIYLVLLEACLRVPMAAHSSAIFRRLYDHYATGVIPTINAAGELELVALHPTLNVAPV ELFRLCSTMAACLQWDSMAGGSGRTFSPEDVLELLNPHYDRYMQLVFELGHCNVTDGPL LSEDAVKRVADALSGCPPRGSVSETEHALSLFKIIWGELFGVQLAKSTQTFPGAGRVKNL TKRAIVELLDAHRIDHSACRTHRQLYALLMAHKREFAGARFKLRAPAWGRCLRTHASGAQ PNTDIILEAALSELPTEAWPMMQGAVNFSTL*

Gene matched: gi | 136806 | sp| P10193 |UL09_HSV11 Gene name: ORIGIN OF REPLICATION BINDIN

[SEQ ID NO: 28]

ORF # = 2 from Contig 103 ORF start site = 3160 ORF end site = 4590 ORF sequence: VYCSHSSSPMGRRAPRGSPEAAPGADVAPGARAA WVWCVQVATFIVSAICWGLLVLAS VFRDRFPCLYAPATSYAEANATVEVRGGVAVPLRLDTQSLLATYAITSTLLLAAAVYAAV GAVTSRYERALDAARRLAAARMAMPHATLIAGNVCAWLLQITVLLLAHRISQLAHLIYVL HFACLVYLAAHFCTRGVLSGTYLRQVHGLIDPAPTHHRIVGPVRAVMTNALLLGTLLCTA AAAVSLNTIAALNFNFSAPSMLICLTTLFALLWSLLLWEGVLCHYVRVLVGPHLGAIA ATGIVGLACEHYHTGGYYWEQQ PGAQTGVRVALALVAAFALAMAVLRCTRAYLYHRRH HTKFFVRMRDTRHRAHSALRRVRSSMRGSRRGGPPGDPGYAETPYASVSHHAEIDRYGDS DGDPIYDEVAPDHEAELYARVQRPGPVPDAEPIYDTVEGYAPRSAGEPVYSTVRR *

Gene matched: gi | 136810 | sp | P04288 |VIMP_HSV11 Gene name: PROBABLE INTEGRAL MEMBRANE P

[SEQ ID NO: 29] ORF # = 3 from Contig 103 ORF start site = 6853 ORF end site = 4784 ORF sequence: MAAAATPGAKRPADPARDPDSPPKRPRPNSLDLATVFGPRPAPPRPTSPGAPGSHWPQSP PRGQPDGGAPGEKARPASPALSEASSGPPTPDIPLSPGGAHAIDPDCSPGPPDPDPM SA SAIPNALPPHILAETFERHLRGLLRGVRSPLAIGPLWARLDYLCSLWSLEAAGMVDRGL GRHL RLTRRAPPSAAEAVAPRPLMGFYEAATQNQADCQL ALLRRGLTTASTLRWGAQG PCFSSQ LTHNASLRLDAQSSAVMFGRVNEPTARNLLFRYCVGRADAGVNDDADAGRFVF HQPGDLAEENVHACGVLMDGHTGMVGASLDILVCPRDPHGYLAPAPQTPLAFYEVKCRAK YAFDPADPGAPAASAYEDLMARRSPEAFRAFIRSIPNPGVRYFAPGRVPGPEEALVTQDR DWLDSRAAGEKRRCSAPDRALVELNSGWSEVLLFGVPDLERRTISPVAWSSGELVRREP IFANPRHPNFKQILVQGNVPRQPLSRLPPATAPGDVPRQAPRGRGGGRDVPPGGRPRSAR RA RGPRTRQGIDPPGPGRSDRPDHHPRPRRAGDIPGHPAKQPPGLRRYARQVMGLAFSG ARPCCCRHNVIITDGGEWSLTAHEFDWDIESEEEGNFYVPPDMRWTRAPGPQYRRAS DPPSRHTRRRDPDVARPPATLTPPLΞDSE* Gene matched: gi | 119694 | sp [ P06489 | EXON_HSV2 Gene name: ALKALINE EXONUCLEASE. gi 13302

[SEQ ID NO: 30] ORF # = 4 from Contig 103 ORF start site = 5313 ORF end site = 4990 ORF sequence:

VTFLGRHRAGAEEGVTFRLEDGRGAPAGRGGAPGPAKASILPDQAVPIALIITPVRVEPG IYRDIRRNSRLAFDDTLAKL ASRSPGRGPAAADTTSSSPTAGRSSR*

Gene matched: gi | 330252

Gene name: (M11854) 1.9kD ORF [Herpes simplex virus type 2]

[SEQ ID NO: 31]

ORF # = 5 from Contig 103 ORF start site = 8477 ORF end site = 6894 ORF sequence : VGGRRPGGRMDESGRQRPASHVAADISPQGAHRRSFKAWLASYIHSLSRRASGRPSGPSP RDGAVSGARPGSRRRSSFRERLRAGLSR RVSRSSRRRSSPEAPGPAAKLRRPPLRRSET AMTSPPSPPSHILSLARIHKLCIPVFAVNPALRYTTLEIPGARSFGGSGGYGEVQLICEH KLAVKTIREKEWFAVELVATLLVGECAFCGGRTHDIRGFITPLGFSLQQRQIVFPAYDMD LGKYIGQLASLRATTPSVATALHHCFTDLARAWFLNTRCGISHLDIKCANVLVMLRSDA VSLRRAVLADFSLVTLNSNSTISRGQFCLQEPDLESPRGFGMPAALTTANFHTLVGHGYN QPPELLVKYLNNERAEFNNRPLKHDVGLAVDLYALGQTLLELLVSVYVAPSLGVPVTRVP GYQYFNNQLSPDFAVALLAYRCVLHPALFVNSAETNTHGLAYDVPEGIRRHLRNPKIRRA FTEQCINYQRTHKAVLSSVSLPPELRPLLVLVSRLCHANPAARHSLS*

Gene matched: gi | 125628 | sp | P04290 | KR2_HSV11 Gene name: PROBABLE SERINE/THREONINE-PRO

[SEQ ID NO: 32]

ORF # = 6 from Contig 103

ORF start site = 8113

ORF end site = 8352

ORF sequence : MAVSDLRRGGRLSLAAGPGASGDERRRDERLTRHRDSPARSRSRKLDRRRDPGRAPETAP SRGEGPLGRPDARRLRECM*

Gene matched: gi | 93505 |pir | | B34768

Gene name: ORF5 protein - Orf virus (strain NZ2)

[SEQ ID NO: 33]

ORF # = 7 from Contig 103 ORF start site = 8863

ORF end site = 8204

ORF sequence:

MSRDASHAALRRRLAETHLRAEVYRDQTLQLHREGVSTQDPRFVGAFMAAKAAHLELEAR

LKSRARLEMMRQRATCVKIRVEEQAARRDFLTAHRRYLDPALSERLDAADDRLADQEEQL EEAAANASL GDGDLADGWMSPGDSDLLVMWQLTSAPKVHTDAPSRPGSRPTYTPSAAGR

PDAQAAPPPETAPSPEPAPGPAADPAΞGSGFARDCPDGE*

Gene matched: gi | 136823 | sp | P04291 |UL14_HSV11 Gene name: HYPOTHETICAL UL14 PROTEIN, g

[SEQ ID NO:34]

ORF # = 8 from Contig 103

ORF start site = 8749 ORF end site = 10242 ORF sequence:

VYSRPPGVAAGSGPCTPRPGGASRPNVGAGPRG RLGSSRRPRARPTSDSFAPTPLTSAA PASPAMFGQQLASDVQQYLERLEKQRQQKVGVDEASAGLTLGGDALRVPFLDFATATPKR HQTWPGVGTLHDCCEHSPLFSAVARRLLFNSLVPAQLRGRDFGGDHTAKLEFLAPELVR AVARLRFRECAPEDAVPQRNAYYSVLNTFQALHRSEAFRQLVHFVRDFAQLLKTSFRASS LAENTGPPKKRAKVDVATHGQTYGTLELFQKMILMHATYFLAAVLLGDHAEQVNTFLRLV FEIPLFSDTAVRHFRQRATVFLVPRRHGKTWFLVPLIALSLASFRGIKIGYTAHIRKATE PVFDEIDACLRG FGSSRVDHVKGETISFSFPDGSRSTIVFASSHNTNVSTPSSRGACFP GAALPEIDRQTNTARRECGTTRPQPPPPWRGEALLFICNRTMRLWPRPARPRGSSLQTGG YTMTERRGATRRWSGG*

Gene matched: gi | 74013 |pir| |WMBE31

Gene name: 38K protein - human herpesvirus 1 gi | 5

[SEQ ID NO: 35] ORF # = 9 from Contig 103 ORF start site = 11332 ORF end site = 10115 ORF sequence:

VFLFHRSPTPPPKSYTR PLCFWCVSGPFPTTNMAQRAVWRPQGTPGPPGAAAPPGHRGA

PPDARAPDPGPEADLVARIANSVFVWRWRGDERLKIFRCLTVLTEPLCQVALPDPDPER

ALFCEIFLYLTRPKALRLPSNTFFAIFFFNRERRYCATVHLRSVTHPRTPLLCTLAFGHL

EAASPPEETPDPAAEQLADEPVAHELDGAYLVPTEPPPNPGACCALGPGAW HLPGGRIY

C AMDDDLGSLCPPGSRARHLG LLSRITDPPGGGGACAPTAHIDSANAL RAPAVAEAC

PCVAPCMWSNMAQRTLAVRGDASLCQLLFGHPVDAVILRQATRRPRITAHLHEVWGRDG

AESVIRPTSAGWRLCVLSSYTSRLFATSCPAVARAVARASSSDYK*

Gene matched: gi | 136829 | sp | P10200 |UL16_HSV11 Gene name: PROTEIN UL16. gi I 73879 Ipir I I

[ SEQ ID NO : 36 ]

ORF # = 10 from Contig 103

ORF start site = 12706

ORF end site = 11336

ORF sequence : FLTGYFRVHGIDKLDQRAVQDVTRRHPVRARPKHAASGVXSGLRQGALVHXAVSGGALGA

SDAEAVLAGLEPPGGGRFATPGGPRAAGDDVLNDVLTLVPGTAKPRSLVE LDRGWEPLA

GGDRPDWLWSRRSISWLRHHYGTKQRFVWSYKNSVA GGRRTRPPLLSSYLATALTEA

CAAERWRPHQLSPAAQTALLRRFPALEGPLRHPRPVLQPFDIAAEVAFVARIQIACLRA

LGHSIRAALQGGPRIFQRLRYDFGPHQSE LGEVTRRFPVLLENLMRALEGTAPDAFFHT AYALAVLAHLGGQGGRGRRRRLVPLSDDIPARFADSDAHYAFDYYSTSGDTLRLTNRPIA

WIDGDVNGREQSKCRFMEGSPSTAPHRVCEQYLPGESYAYLCLGFNRRLCGLWFPGGF

AFTINTAAYLSLADPVARAVGLRFCRGAGTGPGLVR*

Gene matched : gi | 136835 | sp | P10201 | UL17_HSV11 Gene name : PROTEIN UL17 . gi | 73875 | pir | |

[ SEQ ID NO : 37 ] = Contig ID 104

[ SEQ ID NO : 38 ]

ORF # = 1 from Contig 104

ORF start site = 3027 ORF end site = 262

ORF sequence :

VSGRAGDPAGLPAPRGGPT PMPSGGPPPEVKAGLRADMWGVMGQYREAXEHQTPDTETV

VAGMHPALVWLKTMFXDAPETPVLVQFFSDHAPTIAKAVSNAINAGSAAVATASPAATV

DAAVRAHGALADAVSALGAAARDPASPLSFLAALADSAAGYVKATRLALEARGAIDKLTT LGSAAADLVFHARRACAQPEGDHAALIDAAARATTAARESLAGHEAGFGGLLHAEGTAGD HSPSGRALQELGKVIGATRRRAEELEAAVADLTGKMAAQRARGSSERWAAGVEAALDRVE NRAEFDWELRRLQALAGTHGYNPRDFRKRAEQALAANAEAVTLALDTAFAFNPYTPENQ RHPMLPPLAAIHRLG SAAFHAAAETYADMFRVDAEPLARLLRIAEGLLEMAQAGDGFID YHEAVGRLADDMTSVPGLRRYVPFFQHGYADYVELRDRLDAIRADVHRALGGVPLDLAAA AEQISAARNDPEATAELVRTGVTLPCPSEDALVACAAALERVDQSPVKNTAYAEYVAFVT RQDTAETKDAWRAKQQRAEATERVMAGLREALAARERRAQIEAEGLANLKTMLKWAVP ATVAKTLDQARSVAEIADQVEVLLDQTEKTRELDVPAVI LEHAQRTFETHPLSAARGDG PGPLARHAGRLGALFDTRRRVDALRRSLEEAEAE DEVWGRFGRVRGGA KSPEGFRAMH EQLRALQDTTNTVSGLRAQPAYERLSARYQGVLGAKGAERAEAVEELGARVTKHTALCAR LRDEWRRVP EMNFDALGRLLAEFDAAAADLAPWAVEEFRGARELIQYRMGLYSAYARA GGKALFLFFFFPPPLSSFLPHFHFFIHHHHSFTKFFTSSSLHSYHLFPSSIYSIPSISPL YPHSSLSFPSSQFLHIFLSLP*

Gene matched: gi | 135576 | sp | P10220 |TEGU_HSV11 Gene name: LARGE TEGUMENT PROTEIN (VIRI

[SEQ ID NO: 39]

ORF # = 2 from Contig 104 ORF start site = 3914

ORF end site = 2901

ORF sequence :

VMPVAPPPRGAGGRAPCPPALGPEAIHARLEDVRIQARRAIESAIKEYFHRGAVYSAKAL

QASDSHDCRFHVASAAWPMVQLLESLPAFDQHTRDVAQRAALPPPPPLATSPQAILLRD LLQRGQTLDAPEDLAA LSVLTDAATQGLIERKPLEELARSIHGINDQQARRSSGLAELQ

RFDALDAALAQQLDSDAAFVPATGPAPYVDGGGLSPEATRMAEDALRQARAMEAAKMTAE

LAPEARSRLRERAHALEAMLNDARERAKVAHDAREKFLHKLQGVLRPLPDFVGLKACPAV

LATLRASLPRGVDRPGRCRPGAPPRKSRRGCGRTCGG*

Gene matched : gi | 221757

Gene name : (D10879 ) virion protein [Herpes simplex virus typ

[SEQ ID NO: 40]

ORF # = 3 from Contig 104 ORF start site = 6099 ORF end site = 3643 ORF sequence: WTGVRNQFATDLEPGGSVSCMRSSLSFLSLLFDVGPRDVLSAEAIEGCLVEGGEWTRAA AGSGPPRMCSIIELPNFLEYPAARGGLRCVFSRVYGEVGFFGEPTAGLLETQCPAHTFFA GP AMRPLSYTLLTIGPLGMGLYRDGDTAYLFDPHGLPAGTPAFIAKVRAGDVYPYLTYY AHDRPKVR AGAMVFFVPSGPGAVAPADLTAAALHLYGASETYLQDEPFVERRVAITHPL RGEIGGLGALFVGWPRGDGEGSGPWPALPAPTHVQTPRADRPPEAPRGASGPPNTPQA GHPNRPPDDV AAALEGTPPAKPSAPDAAASGPPHAAPPPQTPAGDAAEEAEDLRVLEVG AVPVGCHRARYSTGLPKRRRPT TPPSSVEDLTSGERPAPKAPPAKAKKKSAPKKKAPVA AEVPASSPTPIAATVPPAPDTPPQSGQGGGDDGPASPSSPSVLETLGARRPPEPPGADLA QLFEVHPNVAATAVRLAARDAALAREVAACSQLTINALRSPYPAHPGLLELCVIFFFERV LAFLIENGARTHTQAGVAGPAAALLDFTLRMPPRKTAVGDFLASTRMSLADVAAHRPLIQ HVLDKNSQIGRLALAKLVLVARDFIRETDAFYGDLADLDLQLRAAPPANLYARLGKWLLE RSRAHPNTLFAPATPTHPEPLLHRIQALAHFARGKKMRVEAEAREMREALYALARGVYSV SQRAGPPDRDARCPPPPGRRRQGPVPARPGPRGHPCAAGGRADPGPPGDRKRDQGVLPPG SRIQREGPAGQRQPRLSVSRGLGRGRAHGPVAGIATGL*

Gene matched: gi | 221757

Gene name: (D10879) virion protein [Herpes simplex virus typ

[SEQ ID NO: 41] ORF # = 4 from Contig 104

ORF start site = 6751

ORF end site = 6269

ORF sequence:

MNAHFANEVQYDLTRDPSSPASLIHVIISSECLAAAGVPLSALVRGRPDGGAAANFRVET QTRPHAPGDCTPWRSAFAAYVPADAVGAILAPVIPAHPDLLPRVPSAGGLFVSLPVACDA

QGVYDPYTVAALRLAWGPWATCARVLLFSYDELTRYRVCG*

Gene matched: gi | 136835 | sp | P10201 |UL17_HSV11 Gene name: PROTEIN UL17. gi | 73875 | pir | |

[SEQ ID NO: 42] ORF # = 5 from Contig 104

ORF start site = 6781

ORF end site = 8052

ORF sequence :

VPEGAWVGGACARPRGPRAHVRLYAVCFVCPQGIRGQDFNLLFVDEANFIRPDAVQTIMG FLNQANCKIIFVSSTNTGKASTSFLYNLRGAADELLNWTYICDDHMPRWTHTNATACS

CYILNKPVFITMDGAVRRTADLFLPDSFMQEIIGGQARETGDDRPVLTKSAGERFLLYRP

STTTNSGLMAPELYVYVDPAFTANTRASGTGIAWGRYRDDFIIFALEHFFLRALTGSAP

ADIARCWHSLAQVLALHPGAFRSVRVAVEGNSSQDSAVAIATHVHTEMHRILASAGANG

PGPELLFYHCEPPGGAVLYPFFLLNKQKTPAFEYFIKKFNSGGVMASQELVSVTVRLQTD PVEYLSEQLNNLIETVSPNTDVRMYSGKRNGAADDLMVAVIMAIYLAAPTGIPPAFFPI

RTS*

Gene matched: gi | 139646 | sp | P04295 |VTER_HSV11 Gene name: PROBABLE DNA PACKAGING PROTE [SEQ ID NO: 43] ORF # = 6 from Contig 104 ORF start site = 9483 ORF end site = 8392 ORF sequence:

VLLSPAPPPLPHGRCPPSLFHHRPGCVALSGPPAPPRSGVSRPGAMITDCFEADIAIPSG ISRPDAAALQRCEGRWFLPTIRRQLALADVAHESFVSGGVSPDTLGLLLAYRRRFPAVI TRVLPTRIVACPVDLGLTHAGTVNLRNTSPVDLCNGDPVSLVPPVFEGQATDVRLESLDL TLRFPVPLPTPLAREIVARLVARGIRDLNPDPRTPGELPDLNVLYYNGARLSLVADVQQL ASVNTELRSLVLNMVYSITEGTTLILTLIPRLLALSAQDGYVNALLQMQSVTREAAQLIH PEAPMLMQDGERRLPLYEALVAWLAHAGQLGDILALAPAVRVCTFDGAAWQSGDMAPVI RYP*

Gene matched: gi | 139191 | sp | P10202 |VP23_HSV11 Gene name: CAPSID PROTEIN VP23. gi|7387

[SEQ ID NO: 44] ORF # = 7 from Contig 104 ORF start site = 13917 ORF end site = 9727 ORF sequence:

VWEGLGLPELGLMEPANPPRNPMAAPARDPPGYRYAAAMVPTGSILSTIEVASHRRLFDF FARVRSDENSLYDVEFDALLGSYCNTLSLVRFLELGLSVACVCTKFPELAYMNEGRVQFE VHQPLIARDGPHPVEQPVHNYMTKVIDRRALNAAFSLATEAIALLTGEALDGTGISLHRQ LRAIQQLARNVQAVLGAFERGTADQMLHVLLEKAPPLALLLPMQRYLDNGRLATRVARAT LVAELKRSFCDTSFFLGKAGHRREAIEA LVDLTTATQPSVAVPRLTHADTRGRPVDGVL VTTAAIKQRLLQSFLKVEDTEADVPVTYGEMVLNGANLVTALVMGKAVRSLDDVGRHLLE MQEEQLEANRETLDELESAPQTTRVRADLVAIGDRLVFLEALEKRIYAATNVPYPLVGAM DLTFVLPLGLFNPAMERFAAHAGDLVPAPGHPEPRAFPPRQLFF GKDHQVLRLSMENAV GTVCHPSLMNIDAAVGGVNHDPVEAANPYGAYVAAPAGPGADMQQRFLNAWRQRLAHGRV RWVAECQMTAEQFMQPDNANLALELHPAFDFFAGVADVELPGGEVPPAGPGAIQATWRW NGNLPLALCPVAFRDARGLELGVGRHAMAPATIAAVRGAFEDRSYPAVFYLLQAAIHGSE HVFCALARLVTQCITSYWNNTRCAAFVNDYSLVSYIVTYLGGDLPEECMAVYRDLVAHVE ALAQLVDDFTLPGPELGGQAQAELNHLMRDPALLPPLVWDCDGLMRHAALDRHRDCRIDA GGHEPVYAAACNVATADFNRNDGRLLHNTQARAADAADDRPHRPADWTVHHKIYYYVLVP AFSRGRCCTAGVRFDRVYATLQNMWPEIAPGEECPSDPVTDPAHPLHPANLVANTVNAM FHNGRVWDGPAMLTLQVLAHNMAERTTALLCSAAPDAGANTASTANMRIFDGALHAGVL LMAPQHLDHTIQNGEYFYVLPVHALFAGADHVANAPNFPPALRDLARHVPLVPPALGANY FSSIRQPWQHARESAAGENALTYALMAGYFKMSPVALYHQLKTGLHPGFGFTWRQDRF VTENVLFSERASEAYFLGQLQVARHETGGGVSFTLTQPRGNVDLGVGYTAVAATATVRNP VTDMGNLPQNFYLGRGAPPLLNNAAAVYLRNAWAGNRLGPAQPLPVFGCAQVPRRAGMD HGQDAVCEFIATPVATDINYFRRPCNPRGRAAGGVYAGDKEGDVIALMYDHGQSDPARPF AATA P ASQRFSYGDLLYNGAYHLNGASPVLSPCFKFFTAADITAKHRCLERLIVETGS AVSTATAASDVQFKRPPGCRELVEDPCGLFQEAYPITCASDPALLRSARDGEAHARETHF TQYLIYDASPLKGLSL*

Gene matched: gi | 137571 | sp| P06491 |VCAP_HSVll Gene name:^' MAJOR CAPSID PROTEIN (MCP) (

[SEQ ID NO: 45] ORF # = 8 from Contig 104 ORF start site = 14832 ORF end site = 14164 ORF sequence:

MTMRDDVPLLDRELVYEAACGGEDGELPLDEQFSLSSYGTSDFFVSSAYSRLPPHTQPVF SKRVVMFAWSFLVLKPLELVAAGMYYG TGRAVAPACIIAAVLAYYVTWLARALLLYVNI KRDRLPLSPPVFWGLCVIMGGAALCALVAAAHETFSPDGLFH ITASQLLPRTDPLRARS LGIACAAGAAMWVAAADCFAAFTNFFLARF TRAILKAPVAF*

Gene matched: gi | 136841 | sp| P10204 |UL20_HSV11 Gene name: MEMBRANE PROTEIN UL20. gi | 73

[SEQ ID NO: 46] ORF # = 9 from Contig 104 ORF start site = 15168 ORF end site = 17081 ORF sequence :

VGRQGERWVGGGNEKNTQRATSGMRPELSLKGRPCVTEAWCPSTDAAIHSGGSSSVRPQ PYARAARARATHGSRSRHRQPLLPPPSSHHPTIPPPPSPPRGSPAMELTYATTLHHRDW FYVTADRNRAYFVCGGSVYSVGRPRDSQPGEIAKFGLWRGTGPKDRMVANYVRSΞLRQR GLREVRPVGEDEVFLDSVCLLNPNVSSERDVINTNDVEVLDECLAEYCTSLQTSPGVLVT GVRVRARDRVIELFEHPAIVNISSRFAYTPSPYVFALAQAHLPRLPSSLEPLVSGLFDGI PAPRQPLDARDRRTDWITGTRAPRPMAGTGAGGAGAKRATVSEFVQVKHIDRWSPSVS SAPPPSAPDASLPPPGLQEAAPPGPPLRELW VFYAGDRALEEPHAESGLTREEVRAVHG FREQAWKLFGSVGAPRAFLGAALALSPTQKLAVYYYLIHRERRMSPFPALVRLVGRYIQR HGLYVPAPDEPTLADAMNGLFRDALAAGTVAEQLLMFDLLPPKDVPVGSDARADSAALLR FVDSQRLTPGGSVSPEHVMYLGAFLGVLYAGHGRLAAATHTARLTGVTSLVLTVGDVDRM SAFDRGPAGAAGRTRTAGYLDALLTVCLARAQHGQSV*

Gene matched: gi | 136845 | sp| P10205 |UL21_HSV11 Gene name: PROTEIN UL21. gi | 73866 |pir | | [SEQ ID NO:47] ORF # = 10 from Contig 104 ORF start site = 19116 ORF end site = 17302 ORF sequence:

VYLSPSALKWPVGVWTTGGLAFGCDAALVRARYGKGFMGWISMRDSPPAEIIWPADKT LARVGNPTDENAPAVLPGPPAGPRYRVFVLGAPTPADNGSALDALRRVAGYPEESTNYAQ YMSRAYAEFLGEDPGSGTDARPSLFWRLAGLLASSGFAFVNAAHAHDAIRLSDLLGFLAH SRVLAGLAARGAAGCAADSVFLNVSVLDPAARLRLEARLGHLVAAILEREQSLAAHALGY QLAFVLDSPAAYGAVAPSAARLIDALYAEFLGGRALTAPMVRRALFYATAVLRAPFLAGA PSAEQRERARRGLLITTALCTSDVAAATHADLRAALARTDHQKNLFWLPDHFSPCAASLR FDLAEGGFILDALAMATRSDIPADVMAQQTRGVASVLTR AHYNALIRAFVPEATHQCSG PSHNAEPRILVPITHNASYWTHTPLPRGIGYKLTGVDVRRPLFITYLTATCEGHAREIE PKRLVRTENRRDLGLVGAVFLRYTPAGEVMSVLLVDTDATQQQLAQGPVAGTPNVFSSDV PSVALLLFPNGTVIHLLAFDTLPIATIAPGFLAASALGWMITAALAGILRWRTCVPFL WRRE*

Gene matched: gi | 138316 | sp | P08356 |VGLH_HΞV1E Gene name: GLYCOPROTEIN H PRECURSOR, gi

[SEQ ID NO:48] ORF # = 11 from Contig 104

ORF start site = 20070

ORF end site = 19117

ORF sequence :

VSISAGVRGQGWHRISTPPKNGAGRSVLVFGLVLPLCFYPHPTPSFGPRLRQQRASDSLR GAEPLWAVGTDTPPSADWQPGRTTMGPGL WMGVLVGVAGGHDTYWTEQIDP FLHGLG

LARTYWRDTNTGRLWLPNTPDASDPQRGRLAPPGELNLTTASVPMLRWYAERFCFVLVTT

AEFPRDPGQLLYIPKTYLLGRPRNASLPELPEAGPTSRPPAEVTQLKGLSHNPGASALLR

SRAWVTFAAAPDREGLTFPRGDDGATERHPDGRRNAPPPGPPAGTPRHPTTNLSIAHLHN

ASVT LAARGLLRTPGR*

Gene matched: gi | 364588 |prf | |1508243Y Gene name: UL22 gene [Human herpesvirus 1]

[SEQ ID NO: 49] ORF # = 12 from Contig 104 ORF start site = 21285 ORF end site = 20155 ORF sequence : MASHAGQQHAPAFGQAARASGPTDGRAASRPSHRQGASEARGDPELPTLLRVYIDGPHGV GKTTTSAQLMEALGPRDNIVYVPEPMTY QVLGASETLTNIYNTQHRLDRGEISAGEAAV VMTSAQITMSTPYAATDAVLAPHIGGEAVGPQAPPPALTLVFDRHPIASLLCYPAARYLM GSMTPQAVLAFVALMPPTAPGTNLVLGVLPEAEHADRLARRQRPGERLDLAMLSAIRRVY DLLANTVRYLQRGGR RED GRLTGVAAATPRPDPEDGAGSLPRIEDTLFALFRVPELLA PNGDLYHIFAWVLDVLADRLLPMHLFVLDYDQSPVGCRDALLRLTAGMIPTRVTTAGSIA EIRDLARTFAREVGGV*

Gene matched: gi | 59823

Gene name: (V00466) thymidine kinase [Herpes simplex virus ty

[ SEQ ID NO : 50 ] ORF # = 13 from Contig 104 ORF start site = 20968 ORF end site = 22032 ORF sequence : VLRWDVRQGLGGPQHLPVSHRLGDVDDIVARPQGLHQLRGGGGLPHPVGSVYINPQQRG QLRI PAGFGGPLAMARTGRRAAVGRPARTSSLTERRRVLLAGVRSHTRFYKAFAREVREF NATRICGTLLTLMSGSLQGRSLFEATRVTLICEVDLGPRRPDCICVFEFANDKTLGGVCV ILELKTCKSISSGDTASKREQRTTGMKQLRHSLKLLQSLAPPGDKWYLCPILVFVAQRT LRVSRVTRLVPQKISGNITAAVRMLQSLSTYAVPPEPQTRRSRRRVAATARPQRPPSPTR DPEGTAGHPAPPESDPPSPGWGVAAEGGGVLQKIAALFCVPVAAKSRPRTKTE*

Gene matched: gi | 136854 | sp | P10208 |UL24_HSV11 Gene name: PROTEIN UL24. gi | 74056 |pir | |

[SEQ ID NO: 51] ORF # = 14 from Contig 104 ORF start site = 22313 ORF end site = 23893 ORF sequence:

MDPYYPFDALDVWEHRRFIVADSRSFITPEFPRDFWMLPVFNIPRETAAERAAVMQAQRT AAAAALENAALQAAELPVDIERRIRPIEQQVHHIADALEALETAAAAAEEADAARDAEAR GEGAADGAAPSPTAGPAAAEMEVQIVRNDPPLRYDTNLPVDLLHMVYAGRGAAGSSGWF GT YRTIQERTIADFPLTTRSADFRDGRMSKTFMTALVLSLQSCGRLYVGQRHYSAFECA VLCLYLLYRTTHESSPDRDRAPVAFGDLLARLPRYLARLAAVIGDESGRPQYRYRDDKLP KAQFAAAGGRYEHGALATHWIATLVRHGVLPAAPGDVPRDTSTRVNPDDVAHRDDVNRA AAAFLARGHNLFLWEDQTLLRATANTITALAVLRRLLANGNVYADRLDNRLQLGMLIPGA VPAEAIARGASGLDSGAIKSGDNNLEALCVNYVLPLYQADPTVELTQLFPGAGRPVPGRP GGAATGVDEARGGYWGRPPGGARAPHRAGAHQPHPHKHHPCGGDY* Gene matched: gi | 136863 | sp | P10209 |UL25_HSV11 Gene name: VIRION PROTEIN UL25. gi 17406

[SEQ ID NO: 52] ORF # = 15 from Contig 104 ORF start site = 23784 ORF end site = 24071 ORF sequence:

WDMLSGARQAALVRLTALELINRTRTNTTPVGEIINAHDALGIQYEQGLGLLAQQARIG LASNAKRFATFNVGSDYDLLYFLCLGFIPQYLSVA*

Gene matched: gi | 136863 | sp | P10209 |UL25_HSV11 Gene name: VIRION PROTEIN UL25. gi 17406

[SEQ ID NO: 53] ORF # = 16 from Contig 104

ORF start site = 24292

ORF end site = 25638

ORF sequence:

VRVPMASAEMRERLEAPLPDRAVPIYVAGFLALYDSGDPGELALDPDTVRAALPPENPLP INVDHRARCEVGRVLAWNDPRGPFFVGLIACVQLERVLETAASAAIFERRGPALSREER

LLYLITNYLPSVSLSTKRRGDEVPPDRTLFAHVALCAIGRRLGTIVTYDTSLDAAIAPFR

HLDPATREGVRREAAEAELALAGRTWAPGVEALTHTLLSTAVNNMMLRDRWSLVAERRRQ

AGIAGHTYLQASEKFKIWGAESAPAPERGYKTGAPGAMDTSPAASVPAPQVAVRARQVAS

SSSSSSSFPAPADMNPVSASGAPAPPPPGDGSYL IPAFHYNQLVTGQSAPHHPPLTACG LPAAGTVAYGHPGAGPSPHYPPPPAHPYPGYAVRGPQSPGGPDRRAGGGHRRRPPGGWAS

GGRRRPRDPGVGEPPPTRGGAAGVRLRP*

Gene matched: gi | 1224097 Gene name: (U49329) UL26 protease [Human herpesvirus 2 ]

[SEQ ID NO: 54]

ORF # = 17 from Contig 104 ORF start site = 25463

ORF end site = 26221

ORF sequence:

MLFAGPSPLEAQIAALVGAIAADRQAGGLPAAAGDHGIRGSANRRRHEVEQPEYDCGRDE

PDRDFPYYPGEARPEPRPVDSRRAARQASGPHETITALVGAVTSLQQELAHMRARTHAPY GPYPPVGPYHHPHADTETPAQPPRYPAEAVYLPPPHIAPPGPPLSGAVPPPSYPPVAVTP GPAPPLHQPSPAHAHPPPPPPGPTPPPAASLPQPEAPGAEAGALVNASSAAHVNVDTARA ADLFVSQMMGSR*

Gene matched: gi | 1224097

Gene name: (U49329) UL26 protease [Human herpesvirus 2]

[SEQ ID NO: 55] = Contig ID 14

[SEQ ID NO: 56] ORF # = 1 from Contig 14 ORF start site = 665 ORF end site = 787 ORF sequence: VKYQPRKLGKFKFNNLRDCGLYQRSPLQKFARLDIQPLLH"

Gene matched: gi | 76474 |pir| |JQ0950

Gene name: ICP 18.5 protein - infectious laryngot

[SEQ ID NO: 57] = Contig ID 3Ϊ

[SEQ ID NO: 58]

ORF # = 1 from Contig 38

ORF start site = 273

ORF end site = 43

ORF sequence: VELTAAQGVLPVSVDSTSGDRAQLNNNNNNNDDDYNNKKQLKPLQTQTTLSHSFEVSSGS

PNTEVEIGERTDYLLK*

Gene matched: gi | 1020200 Gene name: (U31782) minor capsid protein L2 [Human papillom

[SEQ ID NO: 59] = Contig ID 50 [SEQ ID NO: 60]

ORF # = 1 from Contig 50

ORF start site = 365

ORF end site = 3

ORF sequence:

MSRRSPRRRGPRRRPRPGGPTVPRPGAFPTADSQMVPAYDSGTAVESAPAASSLLRR LL

VPQADDSDDADYAGNDDAEWANSPPSEGGGKAPEAPHAAPASACPPPPPRKERGQQRPLP

X

Gene matched: gi | 132753 | sp| P28283 |RL1_HSV2H Gene name: NEUROVIRULENCE FACTOR (ICP34.

[SEQ ID NO: 61] = Contig ID 53

[SEQ ID NO: 62]

ORF # = 1 from Contig 53 ORF start site = 754

ORF end site = 380

ORF sequence:

VETAHARMYPDAPPLRLCRGANVRYRVRTRFGPDTLVPMSPREYRRAVLPALDGRAAASG

AGDAMAPGAPDFCEDEAHSHRACARWGLGAPLRPVYVALGRDTVRGGPADLLGPRREFCA RALL*

Gene matched: gi | 124141 | sp | P08392 | ICP4_HSV11 Gene name: TRANS-ACTING TRANSCRIPTIONAL

[SEQ ID NO: 63] = Contig ID 67

[SEQ ID NO: 64]

ORF # = 1 from Contig 67

ORF start site = 487

ORF end site = 26

ORF sequence: VSDGQHQATVXXEVQASEPYIRVANGFGLWPQGGQGTIDTXELHXDTNLDIRSGDEVHY

HVTAGRR GQLLWATQSVTAFSQEDLLDGAIFYRLNGSLRTRDTLIFSMEMGPVHTDATI

QVTVALEGPLAPLKLVRHKKIYVFXGRGS GIL*

Gene matched: gi | 560570 | bbs | 151525 Gene name : chondroitin sulfate proteoglycan NG2=t

[SEQ ID NO: 65]

ORF # = 2 from Contig 67

ORF start site = 353

ORF end site = 511

ORF sequence :

VELXCVNGALTSLRDHKAKTVGHTDVGLRGLHLXXHSGLVLPIGHTCSWIQP*

Gene matched: gi | 1079684

Gene name: (U39205) Lpel4p [Saccharomyces cerevisiae]

[SEQ ID NO: 66] = Contig ID 74

[SEQ ID NO: 67]

ORF # = 1 from Contig 74

ORF start site = 224

ORF end site = 412

ORF sequence: MITGLDNNVCYPITQFAIYNRLTCDKTYRIMPEYAHEAMNVFVNDQVYN LCGSEIPFKY

LK*

Gene matched: gi] 550075 Gene name: (D10935) cephalosporin-C deacetylase [Bacillus su

[SEQ ID NO: 68] = Contig ID 76

[SEQ ID NO: 69] ORF # = 1 from Contig 76 ORF start site = 111 ORF end site = 1 ORF sequence:

MALTEDASSDSPTSAPEKTPLPVSATAMDQAYRYΞXX

Gene matched: gi | 138297 | sp | P13290 |VGLG_HSV2 Gene name: GLYCOPROTEIN G. gi | 419139 | pir

[SEQ ID NO: 70] = Contig ID 82

[SEQ ID NO: 71] ORF # = 1 from Contig 82 ORF start site = 767 ORF end site = 1156 ORF sequence:

VALAPYVNKTVTGDCLPVLDMETGHIGAYWLVDQTGNVADLLRAAAPA SRRTLLPEHA RNCVRPPDYPTPPASE NSL MTPVGNMLFDQGTLVGALDFHGLRSRHPWSREQGAPAPA GDAPAGHGE*

Gene matched: gi | 124135 | sp | P28284 | ICP0_HSV2H Gene name: TRANS-ACTING TRANSCRIPTIONAL

[SEQ ID NO: 72] = Contig ID 87

[SEQ ID NO: 73] ORF # = 1 from Contig 87

ORF start site =.519

ORF end site = 1475

ORF sequence:

MLNDMQWLASSDSEEETEVGISDDDLHRDSTSEAGSTDTEMFEAGLMDAATPPARPPAER QGSPTPADAQGSCGGGPVGEEEAEAGGGGDVCAVCTDEIAPPLRCQSFPCLHPFCIPCMK

TWIPLRNTCPLCNTPVAYLIVGVTASGSFSTIPIVNDPRTRVEAEAAVRSGTAVDFIWTG

NPRTAPRSLSLGGHTVRALSPTPPWPGTDDEDDDPPDGEGGRGSGTGRGSGTGRGSGTGR

GSGTGRGSGGGQALTGGSRLCLPLQPELISRPPPNTSPPGAAVPGPPLVTPPPLLPNLRP

PAPPGTTLTRGPPFLGRGF

Gene matched: gi | 124135 | sp | P28284 | ICP0_HSV2H Gene name: TRANS-ACTING TRANSCRIPTIONAL

[SEQ ID NO: 74] = Contig ID 89

[SEQ ID NO: 75] ORF # = 1 from Contig 89

ORF start site = 259

ORF end site = 615

ORF sequence:

MLADRWRKHTDGN YWFDNSGEMATGWKKIADK YYFNEEGAMKTGWVKYKDT YYLNAK

EGAMVSNAFIHSAGRNRLVLPQTRPNTGRQARIHSRPRWLDYVKIIMECLSNQNPAYY*

Gene matched: gi | 113676 | sp | PO6653 |ALYS_STRPN Gene name: AUTOLYSIN (N-ACETYLMURAMOYL-

[SEQ ID NO: 76] = Contig ID 90

[SEQ ID NO: 77]

ORF # = 1 from Contig 90

ORF start site = 507 ORF end site = 2702 ORF sequence :

VKTIKSMDMPVATSFLAPDGTPLQYALCFPAVTDKLGALLMRPEAACVRPPLPTDVLESA PTVTAMYVLTWNRLQLALSDAQAANFQLFGRFVRHRQATWGASMDAAAELYVALVATTL TREFGCRWAQLGWASGAAAPRPPPGPRGSQRHCVAFNENDVLVALVAGVPEHIYNFWRLD LVRQHEYMHLTLERAFEDAAESMLFVQRLTPHPDARIRVLPTFLDGGPPTRGLLFGTRLA DWRRGKLSETDPLAPWRSALELGTQRRDAPALGKLSPAQALAAVΞVLGRMCLPSAALAAL WTCMFPDDYTEYDSFDALLAARLESGQTLGPAGGREASLPEAPHALYRPTGQHVAVLAAA THRTPAARVTAMDLVLAAVLLGAPVWALRNTTAFSRESELELCLTLFDSRPGGPDAALR DWSSDIETWAVGLLHTDLNPIENACLAAQLPRLSALIAERPLADGPPCLVLVDISMTPV AVLWEAPEPPGPPDVRFVGSEATEELPFVATAGDVLAASAADADPFFARAILGRPFDASL LTGELFPGHPVYQRPLADEAGPSAPTAARDPRDLAGGDGGSGPEDPAAPPARQADPGVLA PTFLTDATTGEPVPPRMWAWIHGLEELASEDAGGPTPNPAPALLPPPATDQSVPTSQYAP RPIGPAXTARETRPSVPPQQNTGRVPVAPRXDPRPSPPTPSPPADAAVPPPAFSGFAAAF SAAVPRVRRSRR

Gene matched: gi | 135576 | sp | P10220 |TEGU_HSV11 Gene name: LARGE TEGUMENT PROTEIN (VIRI

[SEQ ID NO:78] = Contig ID 91

[SEQ ID NO:79] ORF # = 1 from Contig 91 ORF start site = 364 ORF end site = 2751 ORF sequence :

VCPPPTGATWQFEQPRRCPTRPEGQNYTEGIAWFKENIAPYKFKATMYYKDVTVSQVW FGHRYSQFMGIFEDRAPVPFEEVIDKINAKGVCRSTAKYVRNNMETTAFHRDDHETDMEL KPAKVATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPYDEFVLATGDF VYMSPFYGYREGSHTEHTSYAADRFKQVDGFYARDLTTKARATSPTTRNLLTTPKFTVAW DWVPKRPAVCTMTKWQEVDEMLRAEYGGSFRFSSDAISTTFTTNLTQYSLSRVDLGDCIG RDAREAIDRMFARKYNATHIKVGQPQYYLATGGFLIAYQPLLSNTLAELYVREYMREQDR KPRNATPAPLREAPSANASVERIKTTSSIEFARLQFTYNHIQRHVNDMLGRIAVAWCELQ NHELTLWNEARKLNPNAIASATVGRRVSARMLGDVMAVSTCVPVAPDNVIVQNSMRVSSR PGTCYSRPLVSFRYEDQGPLIEGQLGENNELRLTRDALEPCTVGHRRYFIFGGGYVYFEE YAYSHQLSRADVTTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLDYTEVQRRNQLH DLRFADIDTVIRADANAAMFAGLCAFFEGMGDLGRAVGKWMGWGGWSAVSGVSSFMS NPFGALAVGLLVLAGLVAAFFAFRYVLQLQRNPMKALYPLTTKELKTSDPGGVGGEGEEG AEGGGFDEAKLAEAREMIRYMXLVSAMERTEHKARKKGTSALLSSKVTNMVLRKRNKARY SPLHNEDEAGDEDEL*

Gene matched: gi | 138198 | sp | P06763 |VGLB_HSV23 Gene name: GLYCOPROTEIN B PRECURSOR, gi

[SEQ ID NO: 80] = Contig ID 93

[SEQ ID NO: 81] ORF # = 1 from Contig 93 ORF start site = 533 ORF end site = 1678 ORF sequence : VALFVPLRLGWDPQTGLWRVERASWGPPAAPRAALLDVEAKVNFNPLALAARVAEHPGA RLAWARLAAIRNSPQCASSASLAVTITTRTARFAREYTTLAFPPTSKEGAFADLVEVCEV CLRPRGHPHRVTARVLLPRGYNYFVSAGDGFSAPALVALFRQWHTTVHPAPGALAPVFAF LGPGFEVRGGPLQYFAVLGFPGWPPFTVPAAAAAESVRDLLRGAACTHPLCPGGPGPRWA PRSSCPRGHGRPWPRRRPAASCPPFGKRWRGGTPRPPPSNYSTPRRPSGRSGRRGFVSPG SRPSSWPPSRASGRPGCRKPGGGRAWKGWTRWWRPPPRΞPGPGPCWSAWCRTRATPAPRS GSCSAGSWPPSACRSSRRPAR*

Gene matched: gi | 136802 | sp | P10192 |UL08_HSV11 Gene name: PROTEIN UL8. gi | 73829 | pir | | [SEQ ID NO: 82] ORF # = 2 from Contig 93 ORF start site = 1288 ORF end site = 2448 ORF sequence :

VASEAAGRLLPAFREAVARWHPTATTIQLLDPPAAVGPVWTARFCFSGLQAQLLAALAGL GEAGLPEARGRAGLERLDALVAAAPSEPWARAVLERLVPDACDACPALRQLLGGVMAAVC LQIEQTASSVKFAVCGGTGAAFWGLFNVDPGDADAAHGAIHDARRALEASVRAVLSANGI RPRLAPSLALEGVYTHWTWSQTGAWFWNSRDDTDFLQGFPLRGPAYAAAAEVMRDALRR ILRRPAAGPPEEAVCAARGIMEDACDRFVLDAFGRRLDAEYWSVLTPPGEADDPLPQTAF RGGALLDAEQYWRRWRVCPGGGESVGVPVDLYPRPLVLPPVDCAHHLREILREIQLVFT GVLEGVWGEGGSFVYPFEEKMRFLFP*

Gene matched: gi | 136802 | sp | P10192 | UL08_HSV11 Gene name: PROTEIN UL8. gi I 73829 I pir I | W

[SEQ ID NO: 83] ORF # = 3 from Contig 93 ORF start site = 3631 ORF end site = 2705 ORF sequence :

VRRTRAGASNAGMADPTPADEGTAAAILKQAIAGDRSLVEVAEGISNQALLRMACEVRQV SDRQPRFTATSVLRVDVTPRGRLRFVLDGSSDDAYVASEDYFKRCGDQPTYRGFAVWLT ANEDHVHSLAVPPLVLLHRLSLFRPTDLRDFELVCLLMYLENCPRSHATPSLFVKVSAWL GWARHASPFERVRCLLLRSCHWILNTLMCMAGVKPFDDELVLPHWYMAHYLLANNPPPV LΞALFCATPQSFALQLPGPVPRTDCVAYNPAGVMGSCWKSKDLRSALVYWWLSGSPKRRT SSLFYRFC*

Gene matched: gi | 136798 | sp| P10191 |UL07_HSV11 Gene name: PROTEIN UL7. gi | 73828 |pir | |w

[SEQ ID NO: 84]

ORF # = 4 from Contig 93 ORF start site = 4286

ORF end site = 3570

ORF sequence :

MSPATQLQARDRELRRAQAGALEREHRAADRAAGGGAGRPAEADLLRADYD11DVSKSMD

DDTYVANSFQHQYIPAYGQDLERLSRLWEHELVRCFKILRHRNNQGQETSISYSSGAIAS FVAPYFEYVLRAPRAGALITGSDVILGEEELWEAVFKKTRLQTYLTDVAALFVADVQHAA LPRPPSPTPADFRASASPRGGSRSRTRTRSRSPGRTPRGAPDQGWGVQRRDGRPHARR*

Gene matched: gi | 136794 | sp | P10190 |UL06_HSV11 Gene name: VIRION PROTEIN UL6. gi 173994

[SEQ ID NO: 85] = Contig ID 94

[SEQ ID NO: 86] ORF # = 1 from Contig 94 ORF start site = 3669 ORF end site = 496 ORF sequence:

PRLSRAYLRHARGFEGSPGDTYPLRIGRRQSFPFGPAVSAPRRRARTPVAMSDSALQVPA PAGMTPPSAPPPNGPLQVLLGSLTNLRRPPSPSSEPAGSADEPAFLΞAAKLRAATAAFLL SGAAVGPAEARACWHPLLEQLCALHRAHGLPETALLAENLPGLLVHRMAVALPETPEAAF REMDVIKDTVLAITGSDTTHALEAAGLRTTAALGPVRVRQCAVEWIDRWRTVTQSCLAMN PRTSLEALGEMSLKMSPVPLGQPGANLTTPAYSLLFPSPIVQEGLRFLALVSNWVTLFSA HLQRIDDAALTPLTRALFTLALVDEYLTTPDRGAWPPPLLAQFQHTVREIDPAIMIPPL EATKMVRSREEVRVSTALSRVSPRSACAPPGTLMARVRTDAAVFDPDVPFLSASALAIFR PAVTGLLQLGEPPSAGAQQRLLALLQQTWALVQNSNSPSWINTLTDAGFTPAHCTQYIS ALEGFLVAGVPARTPPGHGLSEIQQLFGCIALAGANVFGLAREYGHYAGYVKTFRRIQGA SEHTHGRLCEAVGLSGGVLSQTLARIMGPAVPTEHLASLRRTLVGEFETAERRFSAGQPS LLRETALIWLDVYGQTHWDLTPTTPATPLSALLPVGPPSHAPSVHLAAATKIRFPALEGI HPNVLADPGFVPYVLALWGDALRATCNAAYLPRPIEFALRVLAWARDFGLGYLPTVEGH RTKLGALITLLEPATRAGVGPTMQMADNIEQLLRELYVIARGAVEQLRPAVQLPPPQPPE VGSSLLLISMYALAARGVMQEFAERADPLVRQLEDAIVLLRLHMRTLAAFFECRFESDGH RLYAWADAHERLGPWRPEAMGDAVSQYCGMYHDAKRALVASLAGLRSWTETTAHLGVC DELAAQVSHEGNVLAWRREIHGFLAIVSGIHARASKLMSGDQVPGFCYMSQFLARWRRL SAGYQAARAATGPERVAEFVQELHDTWKGLQTERALWAPFASSGDQRTAAIQEVMAHAN EDAPPARPQTRRAHKRHDWGAGXTXXGAWVXDWXDS*

Gene matched: gi | 221758

Gene name: (D10879) UL37 [Herpes simplex virus type 1]

[SEQ ID NO: 87] = Contig ID 95

[SEQ ID NO: 88] ORF # = 1 from Contig 95 ORF start site = 371 ORF end site = 18 ORF sequence :

VLLDAPAPTASGRTKTPAQGLAKEVQFSTAPPSPTAPWTPRVAGFNKRVFCAAVGRLAAT HARLAAVQLWDMSRPHTDGDLNELLDLTTIRVTVCEGKNLLQRANELVNPDAAQGI *

Gene matched: gi | 136927 | sp | P10233 |UL49_HSV11 Gene name: TEGUMENT PROTEIN UL49. gi | 73

[SEQ ID NO: 89] ORF # = 2 from Contig 95 ORF start site = 831 ORF end site = 436 ORF sequence:

MTSRRSVKSCPREAPRGTHEELYYGPVSPADPESPRDDFRRGAGPMRARPRGEVRFLHYD EAGYALYRDSSSSEDNDESRDTARPRRSASVAGSHGPGPARAPPPPGGPVGAGGRSHAPP ARTPKMTRGAP*

Gene matched: gi | 136927 | sp | P10233 |UL49_HSV11 Gene name: TEGUMENT PROTEIN UL49. gi | 73

[SEQ ID NO: 90]

ORF # = 3 from Contig 95 ORF start site = 1441 ORF end site = 2550 ORF sequence: MSQWGPRAILVQTDSTNRNADGDWQAAVAIRGGGWQLNMVNKRAVDFTPAECGDSEWAV GRVSLGLRMAMPRDFCAIIHAPAVSGPGPHVMLGLVHSGYRGTVLAVWSPNGTRGFAPG ALRVDVTFLDIRATPPTLTEPSSLHRFPQLAPSPLAGLREDPWLDGALATAGGAVALPAR RRGGSLVYAGELTQVTTEHGDCVHEAPAFLPKREEDAGFDILIHRAVTVPANGATVIQPS LRVLRAADGPEACYVLGRSSLNARGLLVMPTRWPSGHACAFWCNLTGVPVTLQAGSKVA QLLVAGTHALPWIPPDNIHEDGAFRAYPRGVPDATATPRDPPILVFTNEFDADAPPSKRG AGGFGSTGI*

Gene matched: gi | 118955 | sp | P10234 |DUT_HSV11 Gene name: DEOXYURIDINE 5 ' -TRIPHOSPHATE

[SEQ ID NO: 91] ORF # = 4 from Contig 95 ORF start site = 3535 ORF end site = 2756 ORF sequence:

VGWGKAGAEPRACSGMASLLGVLCGWGTRPEEQQYEMIRAADPPSEAEPRLQEALAWNA LLPAPITLDDALESLDDTRRLVKARALARTYHACMVNLERLARHHPGLEGSTIDGAVAAH RDKMRRLADTCMATILQMYMSVGAADKSADVLVSQAIRSMAESDWMEDVAIAERALGLS TSALAGGTRTAGLGATEAPPGPTRAQAPEVASVPVTHAGDRSPVRPGPVPPADPTPDPRH RTSAPKRQASSTEAPLLLA*

Gene matched: gi | 136933 | sp | P10235 |UL51_HSV11 Gene name: PROTEIN UL51. gi | 73813 | pir | |

[SEQ ID NO: 92] ORF # = 5 from Contig 95 ORF start site = 2889 ORF end site = 5042 ORF sequence :

VTGTDATSGACALVGPGGASVAPSPAVRVPPARAEVERPRARSAIATSSMTTSLSAMLRM AWETSTSADLSAAPTDMYICRMVAMHVSARRRILSRCAATAPSMVEPSSPGWWRASLSRL TMQAWYVRARARAFTRRRVSSSDSRASSSVMGAGKSALTTARASCSRGSASEGGSAARII SYCCSSGRVPQPHSTPSRDAIPEHARGSAPAFPHPTPSGFAGAMGTEDCDHEGRSVAAPV EVMALYATDGCVITSSLALLTNCLLGAEPLYIFSYDAYRPDAPNGPTGAPTEQERFEGSR ALYRDAGGLNGDSFRVTFCLLGTEVGVTHHPKGRTRPMFVCRFERADDVAVLQDALGRGT PLLPAHITATLDLEATFALHANIIMALTVAIVHNAPARIGSGSTAPLYEPGESMRSWGR MSLGQRGLTTLFVHHKARVLAAYRRAYYGSAQSPFWFLSKFGPDKKSLVLAARYYLLQAP RLGGAGATYDLQAVKDICATYAIPHDPRPDTLSAASLTSFAAITRFCCTSQYSRGAAAAG FPLYVERRIAADVRETGALEKFIAHDRSCLRVSDREFITYIYLAHFECFSPPRLATHLRA VTTHDPSPAASTEQPSPLGREAVEQFFRHVRAQLNIREYVKQNVTPRETALAGDAAAAYL RARTYAPAALTPAPAYCGVADSSTKMMGRLAEAERLLVPHGWPAFAPTTPGDDAGGGI

Gene matched: gi | 136939 | sp | P10236 |UL52_HSV11 Gene name: DNA REPLICATION PROTEIN UL52

[SEQ ID NO: 93] = Contig ID 96

[SEQ ID NO: 94] ORF # = 1 from Contig 96 ORF start site = 2599 ORF end site = 1064 ORF sequence:

VGGCVDKLPLLKTPGPVARGARWLARATRRMACRKFCGVYRRPDKRQEASVPPETNTAPA FPASTFYTPAEDAYLAPGPPETIHPSRPPSPGEAARLCQLQEILAQMHSDEDYPIVDAAG AEEEDEADDDAPDDVAYPEDYAEGRFLSMVSAAPLPGASGHPPVPGRAAPPDVRTCDΞGK MGATGFTPEELDTMDREALRAIΞRGCKPPSTLAKLVTGLGFAIHGTLIPGSEGCVFDSSH PNYPHRVIVKAGWYASTNHEARLLRRLNHPAILPLLDLHWSGVTCLVLPKYHCDLYTYL SKRPSPLGHLQITAVSRQLLSAIDYVHCEGIIHRDIKTENILINTPENICLGDFGAACFV RGCRSSPFHYGIAGTIDTNAPEVLAGDPYTQVIDIWSAGLVIFETAVHTASLFSAPRDPE RRPCDNQIARIIRQAQVHVDEFPTHAESRLTAHYRSRAAGNNRPAWTRPAWTRYYKIHTD VEYLICKALTFDAALRPSAAELLRLPLFHPK*

Gene matched: gi | 125617 | sp | P13287 | KR1_HSV2 Gene name: SERINE/THREONINE-PROTEIN KINAS

[SEQ ID NO: 95]

ORF # = 2 from Contig 96 ORF start site = 2795

ORF end site = 3373

ORF sequence :

MGWWSWTLLNQRNALPRTSADASPALWSFLLRQCRILASEPLGTPVWRPANLRRLA

EPLMDLPKFTRPIVRTRSCRCPPNTTTGLFAEDDPLESIEILDAPACFRLLHQERPGPHR LYHLWWGAADLCVPFLEYAQKTRLGFRFIAMKTNDAWVGEPWPLPDRFLPERTVSWTPF

PAAPNHPLGKSP*

Gene matched : gi | 137125 | sp | P13292 | US02_HSV2 Gene name : PROTEIN US2 . gi | 419137 I pir | | A

[ SEQ ID NO : 96 ] ORF # = 3 from Contig 96 ORF start site = 3534 ORF end site = 3671 ORF sequence : MGRPEIPDEPSWQTGDDDPQNPGPPLAVGDEWPPSSHVCYPITNL*

Gene matched: gi | 137125 | sp | P13292 |US02_HSV2 Gene name: PROTEIN US2. gi | 419137 | pir | | A [SEQ ID NO:97] ORF # = 4 from Contig 96 ORF start site = 5400 ORF end site = 3853 ORF sequence :

VGRMRVGERERGKKKKEGRRRRKREGGEGKGKEEEGGEEGEVREKGERDRGGGEGGGREK RGEKGDGGGGPRSQHPRFIAGRAPPSWTGHRCGNWRQGVATMADIPPDPPAVNTTPANHA PPSPPPGSRKRRRPVLPSSSESEGKPDTESESSSTESSEDEAGDLRGGRRRSPRELGGRY FLDLSAESTTGTESEGTGPSDDDDDDASDGWLVDTPPRKSKRPRINLRLTSSPDRRAGW FPEVWRNDRPIRAAQPQAPAQSSGDRAAAPRRSARQAQMRSGAAWTLDLHYIRQCVNQLF RILRAAPNPPGSANRLRHLVRDCYLMGYCRTRLGPRTWGRLLQISGGTWDVRLRNAIREV EARFEPAAEPVCELPCLNARRYGPECDVGNLETNGGSTSDDEISDATDSDDTLASHSDTE GGPSPAGRENPESASGGAIAARLECEFGTFDWTSEEGSQPWLSAWADTSSAERSGLPAP GACRATEAPEREDGCRKMRFPAACPYPCGHTFLRP*

Gene matched: gi | 124184 | sp | P04485 | IE68_HSV11 Gene name: IMMEDIATE-EARLY PROTEIN IE68

[SEQ ID NO: 98] = Contig ID 98

[SEQ ID NO: 99]

ORF # = lfrom Contig 98

ORF start site = 612

ORF end site = 872

ORF sequence: MVMAACPTEPPGGSVGPADQPRVQSSRTWRPPLVNSRELYRAQRAARCASSSDTPQAPGW

CGGTCRHAVFGWAWWIILAFLWR*

Gene matched: gi | 136952 | sp| P28282 |UL56_HSV2H Gene name: PROTEIN UL56. gi I 73833 Ipirl I

[SEQ ID NO: 100]

ORF # = 2 from Contig 98 ORF start site = 1689

ORF end site = 1045

ORF sequence :

MWGPGPARFIARPGTHGRRVFTDPPPRNMTTTPLSNLFLRAPDITHVAPPYCLNATWQAE

NALHTTKTDPACLAARSYLVRASCSTSGPIHCFFFAVYKDSQHSLPLVTELRNFADLVNH PPVLRELEDKRGGRLRCTGPFSCGTIKDVSGASPAGEYTINGIVYHCHCRYPFSKTCWLG ASAALQHLRFISSSGTAARAAEQRRHKIKIKIKV*

Gene matched: gi | 136947 | sp | P28281 |UL55_HSV2H Gene name: PROTEIN UL55. gi | 73806 | pir | |

[SEQ ID NO:101]

ORF # = 3 from Contig 98 ORF start site = 2705

ORF end site = 1821

ORF sequence:

MALSLTPPHADGRAPVPERKAPSADTIDPAVRAVLRSISERAAVERISESFGRSALVMQD

PFGGMPFPAANSPWAPVLATQAGGFDAETRRVSWETLVAHGPSLYRTFAANPRAASTAKA MRDCVLRQENLIEALASADETLAWCKMCIHHNLPLRPQDPIIGTAAAVLENLATRLRPFL

QCYLKARGLCGLDDLCSRRRLSDIKDIASFVLVILARLANRVERGVSEIDYTTVGVGAGE

TMHFYIPGACMAGLIEILDTHRQECSSRVCELTASHTIAPLYVHGKYFYCNSLF*

Gene matched: gi | 124181 | sp | P28276 | IE63_HSV2H Gene name: TRANSCRIPTIONAL REGULATOR IE

[SEQ ID NO: 102]

ORF # = 4 from Contig 98 ORF start site = 4922 ORF end site = 3906 ORF sequence: MLAVRSLQHLTTVIFITAYGLVLAWYIVFGASPLHRCIYAVRPAGAHNDTALVWMKINQT LLFLGPPTAPPGGAWTPHAHVCYANIIEGRAVSLPAIPGAMSRRVMNVHEAVNCLEALWD TQMRLVWGWFLYLAFVALHQRRCMFGWSPAHSMVAPATYLLNYAGRIVSSVFLQYPYT KITRLLCELSVQRQTLVQLFEADPVTFLYHRPAVGVIVGCELLLRFVALGLIVGTALISR GACAITYPLFLTITTWCFVSIIALTELYFILRRDSAPKNAEPAAPRGRSKGWSGVCGRCC SIILSGIAVRLCYIAWAGWLMALRYEQEIQRRLFDL*

Gene matched: gi | 116105 | sp| P22485 |CELF_HSV2H Gene name: CELL FUSION PROTEIN PRECURSO

[SEQ ID NO: 103] ORF # = 5 from Contig 9i ORF start site = 6334 ORF end site = 4874 ORF sequence:

AAFDLEVPGHRPFAPGPALPPGGLAVGGHMYVNRNEIFNAALAVTNIILDLDIALKEPVP FPRLHEALGHFMRGALAAVXLLFPAARVNPDAYPCYFFKSACRPRAPPVCAGDGPSAGGD DGDGDWFPDAGGDDGDEEWEEDTDPMDTTHGPLPDDEAAYLDLLHEQIPAATPSEPDSW CSCADKIGLRVCLPVPAPYWHGSLTMRGVARVIQQAVLLDRNFVEAVGSHVKNFLLIDT GVYAHGHSLRLPYFAKIGPDGSACGRLLPVFVIPPACEDVPAFVAAHADPRRFHFHAPPM FSAAPREIRVLHΞLGGDYVSFFEKKASRNALEHFGRRETLTEVLGRYDVRPDAGETVEGF ASELLGRIVACIEAHFPEHAREYQAVSVRRAVIKDDWVLLQLIPGRGALNQSLSCLRFKH GRASRATARTFLALSVGTNNRLCASLCQQCFATKCDNNRLHTLFTVDAGTPCSRSAPSST SRPSSS*

Gene matched: gi | 136939 | sp | P10236 |UL52_HSV11 Gene name: DNA REPLICATION PROTEIN UL52

[ SEQ ID NO : 104 ] = Contig ID 99

[ SEQ ID NO : 105 ]

ORF # = 1 from Contig 99

ORF start site = 213

ORF end site = 659

ORF sequence : VGVGVRGWGGGXCGGLWGGWCWVXWGGWVGVFFCFFLFCXXFXXXXXXXFLAPDLTDPL

LFAYVGFQWNHGLMFWPDIAVYAMLGGAVWISLTQVLGLRRRLHKDPDAGPWAAATLR

GLFFΞVYALGFAAGVLVRPRMAASRRSG *

Gene matched : gi | 807644

Gene name : (M10053 ) unknown protein [Herpes simplex virus ty

[ SEQ ID NO : 106 ]

ORF # = 2 from Contig 99 ORF start site = 757 ORF end site = 2403 ORF sequence :

MGAGVPWTGIKARGAGGPITVRVLGWEVAQKATHPCCSCPREAWSGNPPRCAGRAHRSF AGAGALLVMALGRVGLAVGLWGLLWVGWWLANASPGRTITVGPRGKESNAAPSASPRN ASAPRTTPTPPQPRKATKSKASTAKPAPPPKTGPPKTSSEPVRCNRHNPLARYGLRVQIR CRFPNSTRTESRLQIWRYATATDAEIGTAPSLEEVMVNVSAPPGGQLVYDSAPNRTDPHV IWAEGAGPGASPRLYSWGPLGRQRLIIEELTLETQGMYYWVWGRTDRPSAYGTWVRVRV FRPPSLTIHPHAVLEGQPFKATCTAATYYPGNRAEFVWFEDGRRVFDPAQIHTQTQENPD GFSTVSTVTSAAVGGQGPPRTFTCQLTWHRDSVSFSRRNASGTASVLPRPTITMEFTGDH AVCTAGCVPEGVTFAWFLGDDSSPAEKVAVASQTSCGRPGTATIRSTLPVSYEQTEYICR LAGYPDGIPVLEHHGSHQPPPRDPTERQVIRAVEGAGIGVAVLVAWLAGTAWYLTHAS SVRYRRLR*

Gene matched: gi | 138220 | sp | P06475 |VGLC_HSV23 Gene name: GLYCOPROTEIN C PRECURSOR, gi

[SEQ ID NO: 107] ORF # = 3 from Contig 99 ORF start site = 2634 ORF end site = 3152 ORF sequence:

MAFRASGPAYQPLAPAASPARARVPAVAWIGVGAIVGAFALVAALVLVPPRSSWGLSPCD SGWQEFNAGCVAWDPTPVEHEQAVGGCSAPATLIPRAAAKHLAALTRVQAERSSGYWWVN GDGIRTCLRLVDSVSGIDEFCEELAIRICYYPRSPGGFVRFVTSIRNALGLP*

Gene matched: gi | 136917 | sp | P06483 |UL45_HSV23 Gene name: PROTEIN UL45 HOMOLOG (18 KD

[SEQ ID NO: 108]

ORF # = 4 from Contig 99

ORF start site = 4072

ORF end site = 3419

ORF sequence: MAGAPPRLPPRNPAPPEQRPAAAARPLAAHREAAGVYNAVRTWGPDAEAEPDQMENTYLL

PEDDAAMPAGVGLGSTPAADTTAAAWPAESHAPRAPSEEADSIYESVSEDGGRVYEEIPW

VRVYENICLRRQDAGGAAPPGDAPDSPYIEAENPLYDWGGSALFSPPGATRAPDPGLSLS

PMPARPRTNALANDGPTNVAALSALLTKLKRGRHQSH*

Gene matched: gi | 114350 | sp | P10230 |ATI2_HSV11 Gene name: ALPHA TRANS-INDUCING FACTOR

[SEQ ID NO: 109]

ORF # = 5 from Contig 99

ORF start site = 5584

ORF end site = 4391

ORF sequence : MQRRARGASSLRLARCLTPANLIRGANAGVPERRIFAGCLLPTPEGLLSAAVGVLRQRAD DLQPAFLTGADRSVRLAARHHNTVPESLIVDGLASDPHYDYIRHYASAAKQALGEVELSG GQLSRAILAQYWKYLQTVVPSGLDIPDDPAGXCDPSLHVLMRPTLLPKLWRAPFKSGAA AAKYAAAVAGLRDAAHRLQQYMFFMRPADPSRPSTDTALRLSELLAYVSVLYHWASWMLW TADKYVCRRLGPADRRFVALSGSLEAPAETFARHLDRGPSGTTGSMQCMALRAAVSDVLG HLTRLAHLWETGKRSGGTYGIVDAIVSTVEVLSIVHHHAQYIINATLTGYWWASDSLNN EYLRAAVDSQERFCRTAAPLFPTMTAPSWARMELSIK*

Gene matched: gi | 114351 | sp | P08314 |ATI2_HSV1F Gene name: ALPHA TRANS-INDUCING FACTOR

[SEQ ID NO: 110]

ORF # = 6 from Contig 99 ORF start site = 7758 ORF end site = 5668 ORF sequence :

MSVRGHAVRRRRASTRSHAPSAHRAESPVEDEPEGGGVGLMGYLRAVFNVDDDSEVEAAG EMASEEPPPRRRREARGHPGSRRASEARAAAPPRRASFPRPRSVTARSQSVRGRRDSAIT RAPRGGYLGPMDPRDVLGRVGGSRWPSPLFLDELSYEEDDYPAAVAHDDGAGARPPATV EIIEGRVSGPELQAAFPLDRLTPRVAAWDESVRSALALGHPAGFYPCPDSAFGLSRVGVM HFASPADPKVFFRQTLQQGEALAWYVTGDAILDLTDRRAKTSPSRAMGFLVDAIVRVAIN GWVCGTRLHTEGRGSELDDRAAELRRQFASLTALRPVGAAAVPLLΞAGGAAPPHPGPDAA VFRSSLGSLLYWPGVRALLGRDCRVAARYAGRMTYIATGALLARFNPGAVKCVLPREAAF AGRVLDVLAVLAEQTVQWLSVWGARLHPHSAHPAFADVEQEALFRALPLGSPGWAAEH EALGDTAARRLLATSGLNAVLGAAVYALHTALATVTLKYALACGDARRRRDNAAAARAVL ATGLILQRLLGLADTWACVALAAFDGGΞTAPEVGTYTPLRYACVLRATQPLYARTTPAK FWADVRAAAEHVDLRPASSAPRAPVSGTADPAFLLEDLAAFPPAPLNSESVLGPRVRWD IMAQFRKLLMGDEETAALRAHVSGRRATGLGGPPRP*

Gene matched: gi | 136920 | sp | P10231 |UL47_HSV11 Gene name: VIRION PROTEIN UL47 (82/81 K

[SEQ ID NO: 111]

ORF # = 7 from Contig 99 ORF start site = 9949

ORF end site = 8279

ORF sequence:

VILKMRGGGREMSVIGDARHPRQFPSQGPRPFSVAGPGSLPPSPPPGARALLIRLSKSLS

PDPTAPMDLLVNNLFADADGVSPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPV PPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSGFPTNADMYRECKFLSTLPSDVIDWG DAHVPERSPIDIRAHGDVAFPTLPATRDELPSYYEAMAQFFRGELRAREESYRTVLANFC SALYRYLRASVRQLHRQAHMRGRNRDLREMLRTTIADRYYRETARLARVLFLHLYLFLSR EILWAAYAEQMMRPDLFDGLCCDLESWRQLACLFQPLMFINGSLTVRGVPVEARRLRELN HIREHLNLPLVRSAAAEEPGAPLTTPPVLQGNQARSSGYFMLLIRAKLDSYSSVATΞEGE SVMREHAYSRGRTRNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTA PITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVESPSPGMTHDPVLYGALDVDDFE FEQMFTDAMGIDDFGG*

Gene matched: gi | 1168549 | sp | P29793 |ATIN_HSV23 Gene name: ALPHA TRANS-INDUCING PROTEI

TABLE 2

[SEQ ID NO: 112] = Contig ID 1

[SEQ ID NO: 113] >contigl (start 332 - stop 874)

MRTPADDVSWRYEAPSVIDYARIDGIFLRYHCPGLDTFLWDRHAQRAYLVNPFLFAAGFLEDLSHSVF PA

DTQETTTRRALYKEIRDALGSRKQAVSHAPVRAGCVNFDYSRTRRCVGRRDLRPANTTSTWEPPVSSD DE

ASSQSKPLATQPPVLALSNAPPRRVSPTRGRRRHTRLRRN*

gi|136776|sp|P28278|VGLL_HSV2H GLYCOPROTEIN L PRECURSOR

[SEQ ID NO: 114] >contigl (start 747 - stop 1751)

MKRARSRSPSPPSRPSSPFRTPPHGGSPRREVGAGILASDATSHVCIASHPGSGAGYPTRLAAGSAVQ

RR

RPRGCPPGVMFSASTTPEQPLGLSGDATPPLPTSVPLDWAAFRRAFLIDDAWRPLLEPELANPLTARL

LA EYDRRCQTEEVLPPREDVFSWTRYCTPDDVRWIIGQDPYHHPGQAHGLAFSVRADVPVPPSLRNVLA

AV

KNCYPDARMSGRGCLEKWARDGVLLLNTTLTVKRGAAASHSKLGWDRFVGGWRRLAARRPGLVFMLW

GA

HAQNAIRPDPRQHYVLKFSHPSPLSKVPFGTCQHFLAANRYLETRDIMPIDWSV*

gi|l37039|sp|P28275|UNG_HSV2H URACIL-DNA GLYCOSYLASE

[SEQ ID NO: 115] >contigl (start 1806 - stop 2507) MVKSRVSYRSVMSGVGEERVPSAFTILASWGWTFAPQNHDPGASPNTTPIESIAGTAPDAHVGPLDGE PD RDAISPLTSSVAGDPPGADGPYVTFDTLFMVSSIDELGRRQLTDTIRKDLRLSLAKFSIACTKTΞSFS GT

AARQRKRGAPPQRTCVPRSNKSLQMFVLCKRANAAQVREQLRAVIRSRKPRKYYTRSSDGRLCPAVPV FV HEFVSSEPMRLHRDNVMLSTEPD*

gi 1136782 | sp| P28279 |UL03_HSV2H PROTEIN UL3

[SEQ ID NO:116] >contigl (start 3312 - stop2707) MGNPQTTIAYSLHHPRASLTSALPDAAQWHVFESGTRAVLTRGRARQDRLPRGGWIQHTPIGLLVI ID

CRAEFCAYRFIGRASTQRLERWWDAHMYAYPFDSWVSSSHGESVRSATAGILTWWTPDTIYITATIY GT APEAARGCDNAPLDVRPTTPPAPVSPTAGEFPANTTDLLVEVLREIQISPTLDDADPTPGT*

gi|136788|sp|P28280|UL04_HSV2H PROTEIN UL4

[SEQ ID NO: 117] >contigl (contigl start 6024 - stop 3379)

MAASGGEGSRDVRAPGPPPQQPGARPAVRFRDEAFLNFTSMHGVQPIIARIRELSQQQLDVTQVPRLQ WF

RDVAALEVPTGLPLREFPFAAYLITGNAGSGKSTCVQTLNEVLDCWTGATRIAAQNMYVKLSGAFLS

RP

INTIFHEFGFRGNHVQAQLGQHPYTLASSPASLEDLQRRDLTYYWEVILDITKRALAAHGGEDARNEF

HA LTALEQTLGLGQGALTRLASVTHGALPAFTRSNIIVIDEAGLLGRHLLTTWYCWWMINALYHTPQYA

GR

LRPVLVCVGSPTQTASLESTFEHQKLRCSVRQSENVLTYLICNRTLREYTRLSHSWAIFINNKRCVEH

EF

GNLMKVLEYGLPITEEHMQFVDRFVVPESYITNPANLPGWTRLFSSHKEVSAYMAKLHAYLKVTREGE FV

VFTLPVLTFVSVKEFDEYRRLTQQPTLTMEKWITANASRITNYSQSQDQDAGHVRCEVHSKQQLWAR

ND

ITYVLNSQVAVTARLRKMVFGFDGTFRTFEAVLRDDSFVKTQGETSVEFAYRFLSRLMFGGLIHFYNF

LQ RPGLDATQRTLAYGRLGELTAELLSLRRDAAGASATRAADTSDRSPGERAFNFKHLGPRDGGPDDFPD

DD

LDVIFAGLDEQQLDVFYCHYALEEPETTAAVHAQFGLLKRAFLGRYLILRELFGEVFESAPFSTYVDN

VI

FRGCELLTGSPRGGLMSVALQTDNYTLMGYTYTRVFAFAEELRRRHATAGVAEFLEESPLPYIVLRDQ HG

FMSWNTNISEFVESIDSTELAMAINADYGISSKLAMTITRSQGLSLDKVAICFTPGNLRLNSAYVAM

SR

TTSSEFLHMNLNPLRERHERDDVISEHILSALRDPNWIVY*

gi I 74000 |pir I I MBEU5 gene UL5 protein - human herpesvirus 1 [SEQ ID NO: 118] >contigl (start 5594 - stop 7375) translated

MVLMGRLRNAPEΞLTYMFCAAIRVAPVTTQSRTSLRVCTHVLFPDPALPVMRYAANGNSRSGRPVGTS

KA ATSRNHCRRGTCVTSSCCCESSRMRAMIGWTPCMDVKFKNASSLNRTAGLAPGCCGGGPGARTSREPS

PP

DAAMAAQPΛRAPAMRTRGGDAALCAPEDGWVKVHPTPGTMLFREILLGQMGYTEGQGVYNWRSSEAA

TR

QLQAAIFHALLNATTYRDLEEDWRRHWARGLQPQRLVRRYRNAREGDIAGVAERVFDTWRCTLRTTL LD

FAHGWDCFAPGGPSGPTSFPKYIDWLTCLGLVPILRKTREGEATQRLGAFLRQHTLPRQLATVAGAA

ER

AGPGLLELAVAFDSTRMAEYDRVHIYYNHRRGEWLVRDPVSGQRGECLVLCPPLWTGDRLVFDSPVQR

LC PEIVACHALREHAHICRLRNTASVKVLLGRKSDSERGVAGAARWNKALGEDDETKAGSAASRLVRLI

IN

MKGMRHVGDINDTVRAYLDEAGGHLIDTPAVDHTLPGFGKGGTGRGSAAQDPGARPQQLRQAFQTAW

NN

INGMLEGYINNLFGTIERLRETNAGLATQLQARV

gi|136794|sp|P10190|UL06_HSVll VIRION PROTEIN UL6

[SEQ ID NO: 119] = Contig ID 10 Length: 21036 Type: N Check: 7835 ..

[SEQ ID NO: 120] >contigl0 (start 5688 - stop 1) translated

VAGAAHMIPAALPHPTMKRQGDRDIWTGVRNQFATDLEPGGSVSCMRSSLSFLSLLFDVGPRDVLSA EA

IEGCLVEGGEWTRAAAGSGPPRMCSIIELPNFLEYPAARGGLRCVFSRVYGEVGFFGEPTAGLLETQC

PA

HTFFAGPWAMRPLSYTLLTIGPLGMGLYRDGDTAYLFDPHGLPAGTPAFIAKVRAGDVYPYLTYYAHD

RP KVRWAGAMVFFVPSGPGAVAPADLTAAALHLYGASETYLQDEPFVERRVAITHPLRGEIGGLGALFVG

W

PRGDGEGSGPWPALPAPTHVQTPRADRPPEAPRGASGPPNTPQAGHPNRPPDDVWAAALEGTPPAKP

SA

PDAAASGPPHAAPPPQTPAGDAAEEAEDLRVLEVGAVPVGRHRARYSTGLPKRRRPTWTPPSSVEDLT SG

ERPAPKAPPAKAKKKSAPKKKAPVAAEVPASSPTPIAATVPPAPDTPPQSGQGGGDDGPASPSSPSVL

ET

LGARRPPEPPGADLAQLFEVHPNVAATAVRLAARDAALAREVAACSQLTINALRSPYPAHPGLLELCV

IF FFERVLAFLI ENGARTHTQAGVAGPAAALLDFTLRMLPRKTAVGDFLASTRMSLADVAAHRPL I QHVL

DE

NSQIGRLALAKLVLVARDVIRETDAFYGDLADLDLQLRAAPPANLYARLGEWLLERSRAHPNTLFAPA

TP THPEPLLHRIQALAQFARGEEMRVEAEAREMREALDALARGVDSVSQRAGPLTVMPVPAAPGAGGRAP

CP

PALGPEAIQARLEDVRIQARRAIESAIKEYFHRGAVYΞAKALQASDSHDCRFHVASAAWPMVQLLES

LP

AFDQHTRDVAQRAALPPPPPLATSPQAILLRDLLQRGQTLDAPEDLAAWLSVLTDAATQGLIERKPLE EL

ARSIHGINDQQARRSSGLAELQRFDALDAALAQQLDSDAAFVPATGPAPYVDGGGLSPEATRMAEDAL

RQ

ARAMEAAKMTAELAPEARSRLRERAHALEAMLNDARERAKVAHDAREKFLHKLQGVLRPLPDFVGLKA

CP AVLATLRASLPAGWTDLADAVRGPPPEVTAALRADLWGLLGQYREALEHPTPDTATALAGLHPAFVW

LK

TLFADAPETPVLVQFFSDHAPTIAKAVSNAINAGSAAVATASPAATVDAAVRAHGALADAVSALGAAA

RD

PASPLSFLAALADSAAGYVKATRLALEARGAIDELTTLGSAAADLWQARRACAQPEGDHAALIDAAA RA

TTAARESLAGHEAGFGGLLHAEGTAGDHSPSGRALQELGKVIGATRRRADELEAAVADLTAKMAAQRA

RG

SSERWAAGVEAALDRVENRAEFDWELRRLQALAGTHGYNPRDFRKRAEQALAANAEAVTLALDTAFA

FN PYTPENQRHPMLPPLAAIHRLGWSAAFHAAAETYADMFRVDAEPLARLLRIAEGLLEMAQAGDGFIDY

HE

AVGRLADDMTSVPGLRRYVPFFQHGYADYVELRDRLDAIRADVHRALGGVPLDLAAAAEQISAARNDP

EA

TAELVRTGVTLPCPSEDALVACAAALERVDQSPVKNTAYAEYVAFVTRQDTAETKDAWRAKQQRAEA TE

RVMAGLREALAARERRAQ I EAEGL ANLKTMLKWAVPATVAKTLDQARS VAE I ADQVEVLLDQTEKTR EL

DVPAVIWLEHAQRTFETHPLSAARGDGPGPLARHAGRLGALFDTRRRVDALRRSLEEAEAEWDEVWGR FG RVRGGAWKSPEGFRAMHEQLRALQDTTNTVSGLRAQPAYERLΞARYQGVLGAKGAERAEAVEELGARV TK

HTALCARLRDEWRRVPWEMNFDALGRLLAEFDAAAADLAPWAVEEFRGARELIQYRMGLYSAYARAG GQ TXXXXX

gi|135576|sp|P10220|TEGU_HSVll LARGE TEGUMENT PROTEIN

[SEQ ID NO:121] >contiglO (start 9322 - stop 5978) translated MSDSALQVPAPAGMTPPSAPPPNGPLQVLLGSLTNLRRPPSPSSEPAGSADEPAFLSAAKLRAATAAF L SGAAVGPAEARACWHPLLEQLCALHRAHGLPETALLAENLPGLLVHRMAVALPETPEAAFREMDVIKD

TV

LAITGSDTTHALEAAGLRTTAALGPVRVRQCAVEWIDRWRTVTQSCLAMNPRTSLEALGEMSLKMSPV

PL GQPGANLTTPAYSLLFPSPIVQEGLRFLALVSNWVTLFSAHLQRIDDAALTPLTRALFTLALVDEYLT

TP

DRGAWPPPLLAQFQHTVREIDPAIMIPPLEATKMVRSREEVRVSTALSRVSPRSACAPPGTLMARVR

TD

AAVFDPDVPFLSASALAIFRPAVTGLLQLGEPPSAGAQQRLLALLQQTWALVQNSNSPSWINTLTDA GF

TPAHCTQYISALEGFLVAGVPARTPPGHGLSEIQQLFGCIALAGANVFGLAREYGHYAGYVKTFRRIQ

GA

SEHTHGRLCEAVGLSGGVLSQTLARIMGPAVPTEHLASLRRTLVGEFETAERRFSAGQPSLLRETALI

WL DVYGQTHWDLTPTTPATPLSALLPVGPPSHAPSVHLAAATKIRFPALEGIHPNVLADPGFVPYVLALV

VG

DALRATCNAAYLPRPIEFALRVLAWARDFGLGYLPTVEGHRTKLGALITLLEPATRAGVGPTMQMADN

IE

QLLRELYVIARGAVEQLRPAVQLPPPQPPEVGSSLLLISMYALAARGVLQELAERADPLVRQLEDAIV LL

RLHMRTLAAFFECRFESDGHRLYAWADAHERLGPWRPEAMGDAVSQYCGMYHDAKRALVASLAGLRS

W

TETTAHLGVCDELAAQVSHEGNVLAWRREIHGFLAIVSGIHARASKLMSGDQVPGFCYMSQFLARWR

RL SAGYQAARAATGPERVAEFVQELHDTWKGLQTERALWAPFASSADQRTAAIQEVMAHATEDAPPSPA

AD

LWLTNRHDLGAWGDYSLGPLGQPTWPDSVDLSPQGLAATLSMDWLLINELLQVTDGVFRASAFRPS

AG

PEAPGDLEAQDAGGSTPEPTTPGPQDTQARAPSTRPAGRETVPWPNTPVEDDEMTPQETPPVHP*

gi I 221758 UL37 [Herpes simplex virus type 1]

[SEQ ID NO:122] >contiglO (start 9262 - stop 11211) translated VERTGGSCRRAPGPGARCPTWRPACALGDAARRPRAQTGMTAAALYGGAKYRPGTLRNPGRVASTPRR RG

VLYGALCPGIPFVGSGPGAVGWECVCVGGGRRDGGPDQVYRGRSVGRPNRPFKHLRMHRPSQSDTGTH

QR

RKPPSPVRVRVFSGGVFFLSALLPPHLHHPPPTTRPLAIGGKTMKTKPLPTAPMAWAESAVETTTSPR

EL AGHAPLRRVLRPPIARRDGPVLLGDRAPRRTASTMWLLGIDPAESSPGTRATRDDTEQAVDKILRGAR

RA

GGLTVPGAPRYHLTRQVTLTDLCQPNAERAGALLLALRHPTDLPHLARHRAPPGRQTERLAEAWGQLL

EA

SALGSGRAESGCARAGLVSFNFLVAACAAAYDARDAAEAVRAHITTNYGGTRAGARLDRFSECLRAMV HT HVFPHEVMRFFGGLVSWVTQDELASVTAVCSGPQEATHTGHPGRPCSAVTIPACAFVDLDAELCLGGP GA

AFLYLVFTYRQCRDQELCCVYWKSQLPPRGLEAALERLFGRLRITNTIHGAEDMTPPPPNRNVDFPL AV LAASSQSPRCSASQVTNPQFVDRLYRWQPDLRGRPTARTCTYAAFAELGVMPDNSPRCLHRTERFGAV GV P WI L EG WWRPGGWRAC A *

gi|139176|sp|P22486|VP19_HSV2G CAPSID ASSEMBLY AND DNA MATU

[SEQ ID NO:123] >contiglO (start 11673 - stop 15215) translated

VIRRPVRPFGRTAHPASHGPAAVSVHRVRATVTLVPMANRPAASALAGARSPSERQEPREPEVAPPGG

DH

VFCRKVSGVMVLSSDPPGPAAYRISDSSFVQCGSNCSMIIDGDVARGHLRDLEGATSTGAFVAISNVA AG

GDGRTAWALGGTSGPSATTSVGTQTSGEFLHGNPRTPEPQGPQAVPPPPPPPFPWGHECCARRDARG

GA

EKDVGAAESWSDGPSSDSETEDSDSSDEDTGSGSETLSRSSSIWAAGATDDDDSDSDSRSDDSVQPDV

W RRRWSDGPAPVAFPKPRRPGDSPGNPGLGAGTGPGSATDPRASADSDSAAHAAAPQADVAPVLDSQPT

VG

TDPGYPVPLELTPENAEAVARFLGDAVDREPALMLEYFCRCAREESKRVPPRTFGSAPRLTEDDFGLL

NY

ALAEMRRLCLDLPPVPPNAYTPYHLREYATRLVNGFKPLVRRSARLYRILGILVHLRIRTREASFEEW MR

SKEVDLDFGLTERLREHEAQLMILAQALNPYDCLIHSTPNTLVERGLQSALKYEEFYLKRFGGHYMES

VF

QMYTRIAGFLACRATRGMRHIALGRQGSWWEMFKFFFHRLYDHQIVPSTPAMLNLGTRNYYTSSCYLV

NP QATTNQATLRAITGNVSAILARNGGIGLCMQAFNDASPGTASIMPALKVLDSLVAAHNKQSTRPTGAC

VY

LEPWHSDVRAVLRMKGVLAGEEAQRCDNIFSALWMPDLFFKRLIRHLDGEKNVTWSLFDRDTSMSLAD

FH

GEEFEKLYEHLEAMGFGETIPIQDLAYAIVRSAATTGSPFIMFKDAVNRHYIYDTQGAAIAGSNLCTE IV

HPSΞKRSSGVCNLGSVNLARCVSRRTFDFGMLRDAVQACVLMVNIMIDSTLQPTPQCARGHDNLRSMG

IG

MQGLHTACLKMGLDLESAEFRDLNTHIAEVMLLAAMKTSNALCVRGARPFSHFKRSMYRAGRFHWERF

SN ASPRYEGEWEMLRQSMMKHGLRNSQFIALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGETLRPNTL

LL

KELERTFGGKRLLDAMDGLEAKQWSVAQALPCLDPAHPLRRFKTAFDYDQELLIDLCADRAPYVDHSQ

SM

TLYVTEKADGTLPASTLVRLLVHAYKRGLKTGMYYCKVRKATNSGVFAGDDNIVCTSCAL* gi I 1710385|sp|P09853 |RIR1_HSV23 RIBONUCLEOSIDE-DIPHOSPHATE

[SEQ ID NO: 124] >contiglO (start 15268 - stop 16281) translated MDPAVSPASTDPLDTHASGAGAAPIPVCPTPERYFYTSQCPDINHLRSLSILNRWLETELVFVGDEED VS

KLSEGELGFYRFLFAFLSAADDLVTENLGGLSGLFEQKDILHYYVEQECIEWHSRVYNIIQLVLFHN ND

QARRAYVARTINHPAIRVKVDWLEARVRECDSIPEKFILMILIEGVFFAASFAAIAYLRTNNLLRVTC QS NDLIΞRDEAVHTTASCYIYNNYLGGHAKPEAARVYRLFREAVDIEIGFIRSQAPTDSSILSPGALAAI EN YVRFSADRLLGLIHMQPLYSAPAPDASFPLSLMSTDKHTNFFECRSTSYAGAWNDL*

gi|132624|sp|P03174|RIR2_HSV23 RIBONUCLEOSIDE-DIPHOSPHATE R

[SEQ ID NO: 125] >contigl0 (start 17637 - stop 16564) translated

MRRRGHAFAPGDRGTRAAGPGPAAPWGAPSKPALRLAHLFCIRVLRALGYAYINSGQLEADDACANLY

HT

NTVAYVHTTDTDLLLMGCDIVLDISTGYIPTIHCRDLLQYFKMSYPQFLALFVRCHTDLHPNNTYASV ED

VLRECHWTAPSRSQARRAARRERANSRSLESMPTLTAAPVGLETRISWTEILAQQIAGEDDYEEDPPL

QP

PDVAGGPRDGARSSSSEILTPPELVQVPNAQRVAEHRGYVAGRRRHVIHDAPEALDWLPDPMTIAELV

EH RYVKYVISLISPKERGPWTLLKRLPIYQDLRDEDLARSIVTRHITAPDIADRFLAQLWAHAPPPAFYK

DV

LAKFWDE*

gi I 549322 | sp | P36699 | VHS_HSV2G VIRION HOST SHUTOFF PROTEIN

[SEQ ID NO: 126] >contiglO (start 18537 - stop 19949) translated

MAHLPGGAAAAPLSEDAIPSPRERTEDWPPCQIVLQGAELNGILQAFAPLRTSLLDSLLWGDRGILV

HN

AIFGEQVFLPLDHSQFSRYRWGGPTAAFLSLVDQKRSLLSVFRANQYPDLRRVELTVTGQAPFRTLVQ RI

WTTASDGEAVELASETLMKRELTSFAVLLPQGDPDVQLRLTKPQLTKWNAVGDETAKPTTFELGPNG

KF

SVFNARTCVTFAAREEGASSSTSAQVQILTSALKKAGQAAANAKTVYGENTHRTFSVWDDCSMRAVL

RR LQVGGGTLKFFLTADVPSVCVTATGPNAVSAVFLLKPQRVCLNWLGRTPGSSTGSLASQDSRAGPTDS

QD

FSSEPDAGDRGAPEEEGLEGQARVPPAFPEPPGTKRRHAGAEWPADDATKRPKTGVPAAPTRAESPP

LS

ARYGPEAAEGGGDGGRYACYFRDLQTGDASPSPLSAFRGPQRPPYGFGLP* gi | l36905 | sp | P10226 | VPAP_HSVll DNA POLYMERASE PROCESSIVITY

[ SEQ ID NO : 127 ] >contigl 0 ( start 20031 - stop 21053 ) translated

VCPPPPTNMAWCGSGLRLRPFHPPSPSFFVLRALIRAGPGPFAASPRAPSGPGCGMCRGDSPGVAGG SG

EHCLGGDDGDDGRPRLACVGAIARGFAHLWLQATTLGFVGSWLSRGPYADAMSGAFVIGSTGLGFLR AP

PAFARPPTRVCAWLRLVGGGAAVALWSLGEAGAPPGVPGPATQCLALGAAYAALLVLADDVHPLFLLA PR PLFVGTLGVWGGLTIGGSARYWWIDPRAAAALTAAWAGLGTTAAGDSFSKACPRHRRFCWSAVES PP PRYAPEDAERPTDHGPLLPSTHHQRSPRVCGDGAARPENIWVPWTFAGALALAACAARGS

gi|136909 | sp | P10227 |UL43_HSV11 MEMBRANE PROTEIN UL43

[SEQ ID NO:128] = Contig 11 Length: 2343 Type: N Check: 6656 [SEQ ID NO: 129] >contigll (start 2357 - stop 3) translated

APLLVDLRALDARARASSSPEGHEVDPQLLRRRGEAYLRAGGDPGPLVLREAVSALDLPFATSFLAPD GT

PLQYALCFPAVTDKLGALLMRPEAACVRPPLPTDVLESAPTVTAMYVLTVVNRLQLALSDAQAANFQL

FG

RFVRHRQATWGASMDAAAELYVALVATTLTREFGCRWAQLGWASGAAAPRPPPGPRGSQRHCVAFNEN

DV LVALVAGVPEHIYNFWRLDLVRQHEYMHLTLERAFEDAAESMLFVQRLTPHPDARIRVLPTFLDGGPP

TR

GLLFGTRLADWRRGKLSETDPLAPWRSALELGTQRRDAPALGKLSPAQALAAVSVLGRMCLPSAALAA

LW

TCMFPDDYTEYDSFDALLAARLESGQTLGPAGGREASLPEAPHALYRPTGQHVAVLAAATHRTPAARV TA

MDLVLAAVLLGAPVWALRNTTAFSRESELELCLTLFDSRPGGPDAALRDWSSDIETWAVGLLHTDL

NP

IENACLAAQLPRLSALIAERPLADGPPCLVLVDISMTPVAVLWEAPEPPGPPDVRFVGSEATEELPFV AT AGDVLAASAADADPFFARAILGRPFDASLLTGELFPGHPVYQRPLADEAGPSAPTAARDPRDLAGGDG GS

GPEDPAAPPARQADPGVLAPTLLTDATTGEPVPPRMWAWIHGLEELASDDAGGPTPNPAPALLPPPAT DQ

SVPTSQYAPRPIGPAATARETRPSVPPQQNTGRVPVAPRDDPRPSPPTPSPPADAALPPPAFSGSAAA FS

AAVPRVRRSRXXXXX

gi|l35576|sp|P10220|TEGU_HSVll LARGE TEGUMENT PROTEIN [SEQ ID NO: 130] = Contig 12 Length: 14928 Type: N Check: 1371

[SEQ ID NO: 131] >contigl2 (start 1505 - stop 3) translated MAAAPPAAVSEPTAARQKLLALLGQVQTYVFQLELLRRCDPQIGLGKLAQLKLNALQVRVLRRHLRPG LE

AQAAAFLTPLSVTLELLLEYAWREGERLLGHLETFATTGDVSAFFTETMGLARPCPYHQQIRLETYGG DV RMELCFLHDVENFLKQLNYCHLITPPSGATAALERVREFMVAAVGSGLIVPPELSDPSHPCAVCFEEL cv

TANQGATIARRLADRICNHVTQQAQVRLDANELRRYLPHAAGLSDAARARALCVLDQALARTAAGGGA RA

GPPPADSSΞVREEADALLEAHDVFQATTPGLYAISELRFWLASGDRARHSTMDAFADNLNALAQRELQ QE TAAVAVELALFGRRAEHFDRAFGGHLAALDMVDALIIGGQATSPDDQIEALIRACYDHHLTTPLLRRL VS

PEQCDEEALRRVLARLGAGGATGGAEEEEPRAAAEEGGRRRGAGTPASEDGERGPEPGAQGPESWGDI AT RAAADVXXXXX

gi|124088|sp|P10212|PRTP_HSVlll PROCESSING AND TRANSPORT PRO

[SEQ ID NO:132] >contigl2 (start 5468 - stop 1878) translated

MDTKPKTTTTVKVPPGPMGYVYGRACPAEGLELLSLLΞARSGDADVAVAPLIVGLTVESGFEANVAAV VG

SRTTGLGGTAVSLKLMPSHYSPSVYVFHGGRHLAPSTQAPNLTRLCERARRHFGFSDYAPRPCDLKHE

TT

GDALCERLGLDPDRALLYLVITEGFREAVCISNTFLHLGGMDKVTIGDAEVHRIPVYPLQMFMPDFSR

VI ADPFNCNHRS IGENFNYPLPFFNRPLARLLFEAWGPAAVALRARNVDAVARAAAHLAFDENHEGAAL

PA

DITFTAFEASQGKPQRGARDAGNKGPAGGFEQRLASVMAGDAALALESIVSMAVFDEPPPDITTWPLL

EG

QETPAARAGAVGAYLARAAGLVGAMVFSTNSALHLTEVDDAGPADPKDHSKPSFYRFFLVPGTHVAAN PQ

LDREGHWPGYEGRPTAPLVGGTQEFAGEHLAMLCGFSPALLAKMLFYLERCDGGVIVGRQEMDVFRY

VA

DSGQTDVPCNLCTFETRHACAHTTLMRLRARHPKFASAARGAIGVFGTMNSAYSDCDVLGNYAAFSAL

KR ADGSENTRTIMQETYRAATERVMAELEALQYVDQAVPTALGRLETIIGTREALHTWNNIKQLVDREV

EQ

LMRNLIEGRNFKFRΓSIAEANHAMSLSLDPYTCGPCPLLQLLARRSNLAVYQDLALSQCHGVFAGQSV

EG

RNFRNQFQPVLRRRVMDLFNNGFLSAKTLTVALSEGAAICAPSLTAGQTAPAESSFEGDVARVTLGFP KE LRVKSRVLFAGASANASEAAKARVASLQSAYQKPDKRVDILLGPLGFLLKQFHAVIFPNGKPPGSNQP NP

QWFWTALQRNQLPARLLSREDIETIAFIKRFSLDYGAINFINLAPNNVSELAMYYMANQILRYCDHST YF INTLTAVIAGSRRPPGVQAAAAWAPQGGAGLEAGARALMDSLDAHPGAWTSMFASCNLLRPVMAARPM W

LGLSISKYYGMAGNDRVFQAGNWASLLGGKNACPLLIFDRTRKFVLACPRAGFVCAASSLGGGAHEHS LC

EQLRGIIAEGGAAVASSVFVATVKSLGPRTQQLQIEDWLALLEDEYLSEEMMEFTTRALERGHGEWST DA

ALEVAHEAEALVSQLGAAGEVFNFGDFGDEDDHAASFGGLAAAAGAAGVARKRAFHGDDPFGEGPPEK

KD

LTLDML*

gi|544182|sp|P36384|DNBI_HSV2 MAJOR DNA-BINDING PROTEIN

[SEQ ID NO: 133] >contigl2 (start 6286 - stop 10008) translated

MFCAAGGPTSPGGKSAARAASGFFAPHNPRGATQTAPPPCRRQNFYNPHLAQTGTQPKAPGPAQRHTY

YS ECDEFRFIAPRSLDEDAPAEQRTGVHDGRLRRAPKVYCGGDERDVLRVGPEGF PRRLRLWGGADHAP

EG

FDPTVTVFHVYDILEHVEHAYSMRAAQLHERFMDAITPAGTVITLLGLTPEGHRVAVHVYGTRQYFYM

NK

AEVDRHLQCRAPRDLCERLAAALRES PGASFRGI SADHFEAEWERADVYYYETRPTLYYRVFVRSGR AL

AYLCDNFCPAIRKYEGGVDATTRFILDNPGFVTFGWYRLKPGRGNAPAQPRPPTAFGTSSDVEFNCTA

DN

LAVEGAMCDLPAYKLMCFDIECKAGGEDELAFPVAERPEDLVIQISCLLYDLSTTALEHILLFSLGSC

DL PESHLSDLASRGLPAPWLEFDSEFEMLLAFMTFVKQYGPEFVTGYNIINFDWPFVLTKLTEIYKVPL

DG

YGRMNGRGVFRVWDIGQSHFQKRSKIKVNGMVNIDMYGIITDKVKLSSYKLNAVAEAVLKDKKKDLSY

RD

IPAYYASGPAQRGVIGEYCVQDSLLVGQLFFKFLPHLELSAVARLAGINITRTIYDGQQIRVFTCLLR LA

GQKGFILPDTQGRFRGLDKEAPKRPAVPRGEGERPGDGNGDEDKDDDEDGDEDGDEREEVARETGGRH

VG

YQGARVLDPTSGFHVDPVWFDFASLYPSIIQAHNLCFSTLSLRPEAVAHLEADRDYLEIEVGGRRLF

FV KAHVRESLLSILLRDWLAMRKQIRSRIPQSTPEEAVLLDKQQAAIKWCNSVYGFTGVQHGLLPCLHV

AA

TVTTIGREMLLATRAYVHARWAEFDQLLADFPEAAGMRAPGPYSMRIIYGDTDSIFVLCRGLTAAGLV

AM

GDKMASHISRALFLPPIKLECEKTFTKLLLIAKKKYIGVICGGKMLIKGVDLVRKNNCAFINRTSRAL VD LLFYDDTVSGAAAALAERPAEEWLARPLPEGLQAFGAVLVDAHRRITDPERDIQDFVLTAELSRHPRA YT

NKRLAHLTVYYKLMARRAQVPSIKDRIPYVIVAQTREVEETVARLAALRELDAAAPGDEPAPPAALPS PA KRPRETPSHADPPGGASKPRKLLVSELAEDPGYAIARGVPLNTDYYFSHLLGAACVTFKALFGNNAKI TE SLLKRFIPETWHPPDDVAARLRAAGFGPAGAGATAEETRRMLHRAFDTLA*

gi|118882|sp|P07918|DPOL_HSV21 DNA POLYMERASE

[SEQ ID NO:134] >contigl2 (start 10870 - stop 9953) translated

MYDIAPRRΞGSRPGPGRDKTRRRSRFSAAGNPGVERRASRKSLPSHARRLELCLHERRRYRGFFAALA

QT

PSEEIAIVRSLSVPLVKTTPVSLPFSLDQTVADNCLTLSGMGYYLGIGGCCPACΞAGDGRLATVSREA LI

LAFVQQINTIFEHRTFLASLWLADRHSTPLQDLLADTLGQPELFFVHTILRGGGACDPRFLFYPDPT

YG

GHMLYVIFPGTSAHLHYRLIDRMLTACPGYRFAAHVWQSTFVLWRRNAEKPADAEIPTVSAADIYCK

MR DISFDGGLMLEYQRLYATFDEFPPP*

gi|l36875|sp|P10215|UL31_HSVll PROTEIN UL31

[SEQ ID NO:135] >contigl2 (start 12674 - stop 10863) translated VRPARPAMATSAPGVPSSAAVREESPGSSWKEGAFERPYVAFDPDLLALNEALCAELLAACHWGVPP AS

ALDEDVESDVAPAPPRPRGAAREASGGRGPGSARGPPADPTAEGLLDTGPFAAASVDTFALDRPCLVC RT

IELYKQAYRLSPQWVADYAFLCAKCLGAPHCAASIFVAAFEFVYVMDHHFLRTKKATLVGSFARFALT IN

DIHRHFFLHCCFRTDGGVPGRHAQKQPRPTPSPGAAKVQYSNYSFLAQSATRALIGTLASGGDDGAGA

GG

GSGTQPSLTTALMNWKDCARLLDCTEGKRGGGDSCCTRAAARNGEFEAAAGALAQGGEPETWAYADLI LL LLAGTPAVWESGPRLRAAADARRAAVSESWEAHRGARMRDAAPRFAQFAEPKAQPDLDLGPLMATVLK HG

RGRGRTGGECLLCNLLLVRAYWLAMRRLRASWRYSENNTSLFDCIVPWDQLEADPEAQPGDGGRFV SL

LRAAGPEAIFKHMFCDPMCAITEMEVDPWVLFGHPRADHRDELQLHKAKLACGNEFEGRVCIALRALI YT

FKTYQVFVPKPTALATFVREAGALLRRHSISLLSLEHTLCTYV*

gi 1136879 | sp | P10216 |UL32_HSV11 PROBABLE MAJOR ENVELOPE GLYC

[SEQ ID NO: 136] >contigl2 (start 12652 - stop 13044) translated MAGRAGRTRPRTLRDAIPDCALRSQTLESLDARYVSRDGAGDAAVWFEDMTPAELEVIFPTTDAKLNY

LS

RTQRLASLLTYAGPIKAPDGPAAPHTQDTACVHGELDATERERFAAVINRFLDLHQILRG*

gi 1136883 | sp | P10217 | UL33_HSV11 PROTEIN UL33

[SEQ ID NO: 137] >contigl2 (start 13134 - stop 13964) translated MAGMGKPYGGRPGDAFEGLVQRIRLIVPTTLRGGGGESGPYSPSNPPSRCAFQFHGQDGSDEAFPIEY VL RLMNDWADVPCNPYLRVQNTGVSVLFQGFFNRPHGAPGGAITAEQTNVILHSTETTGLSLGDLDDVKG RL

GLDARPMMASMWISCFVRMPRVQLAFRFMGPEDAVRTRRILCRAAEQALARRRRSRRSQDDYGAVAVA AA HHΞSGAPGPGVAASGPPAPPGRGPARPWHQAVQLFRAPRPGPPALLLLVAGLFLGAAIWWAVGARL*

gi|136888|sp|P10218|UL34_HSVll VIRION PROTEIN UL34

[SEQ ID NO:138] >contigl2 (start 14076 - stop 14414) translated MAAPQFHRPSTITADNVRALGMRGLVLATNNAQFIMDNSYPHPHGTQGAVREFLRGQAAALTDLGVTH AN

NTFAPQPMFAGDAAAEWLRPSFGLKRTYSPFWRDPKTPSTP*

gi|139196|sp|P10219|VP26_HSVll CAPSID PROTEIN VP26

[SEQ ID NO: 139] = Contig ID 13 Length: 838 Type: N Check: 7960

[SEQ ID NO: 140] >contigl3 (start stop 852 - 1) translated RRLYADRLTKRSLASLGRCVREQRGELEKMLRVSVHGEVLPATFAAVANGFAARARFCALTAGAGTVI

DN

RAAPGVFDAHRFMRASLLRHQVDPALLPSITHRFFELVNGPLFDHSTHSFAQPPNTALYYSVENVGLL

PH

LKEELARFIMGAGGSGADWAVSEFQKFYCFDGVSGITPTQRAAWRYIRELIIATTLFASVYRCGELEL RR

PDCSRPTSEGLYRYPPGVYLTYNSDCPLVAIVESGPDGCIGPRSVWYDRDVFSILYSVLQHLAPRLA

GXXXXX

gi 1124089 |sp|P12835 | PRTP_HSVlA PROCESSING AND TRANSPORT PRO

[SEQ ID NO: 141] = Contig ID 14 Length: 2647 Type: N Check: 2951 .. [ SEQ ID NO : 142 ] >contigl4 ( start 2661 - stop 97 ) translated

PPVPSPATTKARKRKTKKPPKRPEATPPPDANATVAAGHATLRAHLREIKVENADAQFYVCPPPTGAT

W

QFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVP FE

EVIDKINAKGVCRSTAKYVRNNMETTAFHRDDHETDMELKPAKVATRTSRGWHTTDLKYNPSRVEAFH

RY

GTTVNCIVEEVDARSVYPYDEFVLATGDFVYMSPFYGYREGSHTEHTSYAADRFKQVDGFYARDLTTK

AR ATSPTTRNLLTTPKFTVAWDWVPKRPAVCTMTKWQEVDEMLRAEYGGSFRFSSDAISTTFTTNLTQYS

LS

RVDLGDCIGRDAREAIDRMFARKYNATHIKVGQPQYYLATGGFLIAYQPLLSNTLAELYVREYMREQD

RK

PRNATPAPLREAPSANASVERIKTTSSIEFARLQFTYNHIQRHVNDMLGRIAVAWCELQNHELTLWNE AR

KLNPNAIASATVGRRVSARMLGDVMAVSTCVPVAPDNVIVQNSMRVSSRPGTCYSRPLVSFRYEDQGP

LI

EGQLGENNELRLTRDALEPCTVGHRRYFIFGGGYVYFEEYAYSHQLSRADVTTVSTFIDLNITMLEDH

EF VPLEVYTRHEIKDSGLLDYTEVQRRNQLHDLRFADIDTVIRADANAAMFAGLCAFFEGMGDLGRAVGK

W

MGWGGWSAVSGVSSFMSNPFGALAVGLLVLAGLVAAFFAFRYVLQLQRNPMKALYPLTTKELKTSD

PG

GVGGEGEEGAEGGGFDEAKLAEAREMIRYMALVSAMERTEHKARKKGTSALLΞSKVTNMVLRKRNKAR YS

PLHNEDEAGDEDEL*

gi|138198|sp|P06763|VGLB_HSV23 GLYCOPROTEIN B PRECURSOR

[SEQ ID NO:143] = Contig ID 15 Length: 20389 Type: N Check: 2794

[SEQ ID NO:144] >contigl5 (start 788 - stop 3) translated MNAHFANEVQYDLTRDPSSPASLIHVIISSECLAAAGVPLSALVRGRPDGGAAANFRVETQTRAHATG

DC

TPWRSAFAAYVPADAVGAILAPVIPAHPDLLPRVPSAGGLFVSLPVACDAQGVYDPYTVAALRLAWGP

WA

TCARVLLFSYDELVPPNTRYAADGARLMRLCRHFCRYVARLGAAAPAAATEAAAHLSLGMGESGTPTP QA

SSVSGGAGPAWGTPDPPISPEEQLTAPGGDTATAEDVSITQENEEIXXXXX

gi | l36835 | sp | P1020 l | UL17_HSVll PROTEIN UL17

[ SEQ ID NO : 145 ] >contigl5 ( start 818 - stop 2089 ) translated VPEGAWVGGACARPRGPRAHVRLYAVCFVCPQGIRGQDFNLLFVDEANFIRPDAVQTIMGFLNQANCK II

FVSSTNTGKASTSFLYNLRGAADELLNWTYICDDHMPRWTHTNATACSCYILNKPVFITMDGAVRR TA DLFLPDSFMQEIIGGQARETGDDRPVLTKSAGERFLLYRPSTTTNSGLMAPELYVYVDPAFTANTRAS GT

GIAWGRYRDDFIIFALEHFFLRALTGSAPADIARCWHSLAQVLALHPGAFRSVRVAVEGNSSQDSA VA

IATHVHTEMHRILASAGANGPGPELLFYHCEPPGGAVLYPFFLLNKQKTPAFEYFIKKFNSGGVMASQ EL

VSVTVRLQTDPVEYLSEQLNNLIETVSPNTDVRMYSGKRNGAADDLMVAVIMAIYLAAPTGIPPAFFP

IT

RTS*

gi | l39646 | sp | P04295 | VTER_HSV11 PROBABLE DNA PACKAGING PROTE

[ SEQ ID NO : 146 ] >contigl5 ( start 3520 - stop 2429 ) translated

VLLSPAPPPLPHGRCPPSLFHHRPGCVALSGPPAPPRSGVSRPGAMITDCFEADIAIPSGISRPDAAA

LQ RCEGRWFLPTIRRQLALADVAHESFVSGGVSPDTLGLLLAYRRRFPAVITRVLPTRIVACPVDLGLT

HA

GTVNLRNTSPVDLCNGDPVSLVPPVFEGQATDVRLESLDLTLRFPVPLPTPLAREIVARLVARGIRDL

NP

DPRTPGELPDLNVLYYNGARLSLVADVQQLASVNTELRSLVLNMVYSITEGTTLILTLIPRLLALSAQ DG

YVNALLQMQSVTREAAQLIHPEAPMLMQDGERRLPLYEALVAWLAHAGQLGDILALAPAVRVCTFDGA

AV

VQSGDMAPVIRYP*

gi|l3919l|sp|P10202|VP23_HSVll CAPSID PROTEIN VP23

[SEQ ID NO: 147] >contigl5 (start 7954 - stop 3764) translated VWEGLGLPELGLMEPANPPRNPMAAPARDPPGYRYAAAMVPTGSILSTIEVASHRRLFDFFARVRSDE NS LYDVEFDALLGSYCNTLSLVRFLELGLSVACVCTKFPELAYMNEGRVQFEVHQPLIARDGPHPVEQPV HN

YMTKVIDRRALNAAFSLATEAIALLTGEALDGTGISLHRQLRAIQQLARNVQAVLGAFERGTADQMLH VL LEKAPPLALLLPMQRYLDNGRLATRVARATLVAELKRSFCDTSFFLGKAGHRREAIEAWLVDLTTATQ ps

VAVPRLTHADTRGRPVDGVLVTTAAIKQRLLQSFLKVEDTEADVPVTYGEMVLNGANLVTALVMGKAV RS

LDDVGRHLLEMQEEQLEANRETLDELESAPQTTRVRADLVAIGDRLVFLEALEKRIYAATNVPYPLVG AM DLTFVLPLGLFNPAMERFAAHAGDLVPAPGHPEPRAFPPRQLFFWGKDHQVLRLSMENAVGTVCHPSL

MN

IDAAVGGVNHDPVEAANPYGAYVAAPAGPGADMQQRFLNAWRQRLAHGRVRWVAECQMTAEQFMQPDN

AN LALELHPAFDFFAGVADVELPGGEVPPAGPGAIQATWRWNGNLPLALCPVAFRDARGLELGVGRHAM

AP

ATIAAVRGAFEDRSYPAVFYLLQAAIHGSEHVFCALARLVTQCITSYWNNTRCAAFVNDYSLVSYIVT

YL

GGDLPEECMAVYRDLVAHVEALAQLVDDFTLPGPELGGQAQAELNHLMRDPALLPPLVWDCDGLMRHA AL

DRHRDCRIDAGGHEPVYAAACNVATADFNRNDGRLLHNTQARAADAADDRPHRPADWTVHHKIYYYVL

VP

AFSRGRCCTAGVRFDRVYATLQNMWPEIAPGEECPSDPVTDPAHPLHPANLVANTVNAMFHNGRVW

DG PAMLTLQVLAHNMAERTTALLC S AAPDAGANTASTANMRI FDGALHAGVLLMAPQHLDHT I QNGEYFY

VL

PVHALFAGADHVANAPNFPPALRDLARHVPLVPPALGANYFSSIRQPWQHARESAAGENALTYALMA

GY

FKMSPVALYHQLKTGLHPGFGFTWRQDRFVTENVLFSERASEAYFLGQLQVARHETGGGVSFTLTQP RG

NVDLGVGYTAVAATATVRNPVTDMGNLPQNFYLGRGAPPLLDNAAAVYLRNAWAGNRLGPAQPLPVF

GC

AQVPRRAGMDHGQDAVCEFIATPVATDINYFRRPCNPRGRAAGGVYAGDKEGDVIALMYDHGQSDPAR

PF AATANPWASQRFSYGDLLYNGAYHLNGASPVLSPCFKFFTAADITAKHRCLERLIVETGSAVSTATAA

SD

VQFKRPPGCRELVEDPCGLFQEAYPITCASDPALLRSARDGEAHARETHFTQYLIYDASPLKGLSL*

gi|137571|sp|P06491|VCAP_HSVll MAJOR CAPSID PROTEIN (MCP)

[SEQ ID NO: 148] >contigl5 (start 8869 - stop 8201) translated MTMRDDVPLLDRELVYEAACGGEDGELPLDEQFSLSSYGTSDFFVSSAYSRLPPHTQPVFSKRWMFA WS

FLVLKPLELVAAGMYYGWTGRAVAPACIIAAVLAYYVTWLARALLLYVNIKRDRLPLSPPVFWGLCVI MG

GAALCALVAAAHETFSPDGLFHWITASQLLPRTDPLRARSLGIACAAGAAMWVAAADCFAAFTNFFLA

RF

WTRAILKAPVAF*

gi|l36841 | sp | P10204 |UL20_HSV11 MEMBRANE PROTEIN UL20

[SEQ ID NO: 149] >contigl5 (start 9205 - stop 11118) translated VGRQGERWVGGGNEENTQRATSGMRPELSLKGRPCVTEAWCPSTDAAIHSGGSSSVRPQPYARAARA RA THGSRSRHRQPLLPPPSSHHPTIPPPPΞPPRGSPAMELSYATTLHHRDWFYVTADRNRAYFVCGGSV

YS

VGRPRDSQPGEIAKFGLWRGTGPKDRMVANYVRSELRQRGLRDVRPVGEDEVFLDSVCLLNPNVSSE

RD VINTNDVEVLDECLAEYCTSLRTSPGVLVTGVRVRARDRVIELFEHPAIVNISSRFAYTPSPYVFALA

QA

HLPRLPSSLEPLVSGLFDGIPAPRQPLDARDRRTDWITGTRAPRPMAGTGAGGAGAKRATVSEFVQV

KH

IDRWSPSVSSAPPPSAPDASLPPPGLQEAAPPGPPLRELWWVFYAGDRALEEPHAESGLTREEVRAV HG

FREQAWKLFGSVGAPRAFLGAALALSPTQKLAVYYYLIHRERRMSPFPALVRLVGRYIQRHGLYVPAP

DE

PTLADAMNGLFRDALAAGTVAEQLLMFDLLPPKDVPVGSDARADSAALLRFVDSQRLTPGGSVSPEHV

MY LGAFLGVLYAGHGRLAAATHTARLTGVTSLVLTVGDVDRMSAFDRGPAGAAGRTRTAGYLDALLTVCL

AR

AQHGQSV*

gi|l36845|sp|P10205|UL21_HSVll PROTEIN UL21

[SEQ ID NO: 150] >contig 15 (start 14107 - stop 11339) translated

VSISAGVRGQGWHRISTPPKNGAGRSVLVFGLVLPLCFYPHPTPSFGPRLRQQRASDSLRGAEPLWAV

GT

DTPPSADWQPGRTTMGPGLWWMGVLVGVAGGHDTYWTEQIDPWFLHGLGLARTYWRDTNTGRLWLPN TP

DASDPQRGRLAPPGELNLTTASVPMLRWYAERFCFVLVTTAEFPRDPGQLLYIPKTYLLGRPRNASLP

EL

PEAGPTSRPPAEVTQLKGLSHNPGASALLRSRAWVTFAAAPDREGLTFPRGDDGATERHPDGRRNAPP

PG PPAGTPRHPTTNLSIAHLHNASVTWLAARGLLRTPGRYVYLSPSASTWPVGVWTTGGLAFGCDAALVR

AR

YGKGFMGLVISMRDSPPAEIIWPADKTLARVGNPTDENAPAVLPGPPAGPRYRVFVLGAPTPADNGS

AL

DALRRVAGYPEESTNYAQYMSRAYAEFLGEDPGSGTDARPΞLFWRLAGLLASSGFAFVNAAHAHDAIR LS

DLLGFLAHSRVLAGLAARGAAGCAADSVFLNVSVLDPAARLRLEARLGHLVAAILEREQSLAAHALGY

QL

AFVLDSPAAYGAVAPSAARLIDALYAEFLGGRALTAPMVRRALFYATAVLRAPFLAGAPSAEQRERAR

RG LLITTALCTSDVAAATHADLRAALARTDHQKNLFWLPDHFSPCAASLRFDLAEGGFILDALAMATRSD

IP

ADVMAQQTRGVASVLTRWAHYNALIRAFVPEATHQCSGPSHNAEPRILVPITHNASYWTHTPLPRGI

GY

KLTGVDVRRPLFI YLTATCEGHAREIEPKRLVRTENRRDLGLVGAVFLRYTPAGEVMSVLLVDTDAT QQ QLAQGPVAGTPNVFSSDVPSVALLLFPNGTVIHLLAFDTLPIATIAPGFLAASALGWMITAALAGIL

RV

VRTCVPFLWRRE*

gi| 138315 |sp|P06477|VGLH_HSVll GLYCOPROTEIN H PRECURSOR

[SEQ ID NO:151] >contigl5 (start 15322 - stop 14192) translated

MASHAGQQHAPAFGQAARASGPTDGRAASRPSHRQGASEARGDPELPTLLRVYIDGPHGVGKTTTSAQ

LM EALGPRDNIVYVPEPMTYWQVLGASETLTNIYNTQHRLDRGEISAGEAAWMTSAQITMSTPYAATDA

VL

APHIGGEAVGPQAPPPALTLVFDRHPIASLLCYPAARYLMGSMTPQAVLAFVALMPPTAPGTNLVLGV

LP

EAEHADRLARRQRPGERLDLAMLSAIRRVYDLLANTVRYLQRGGRWREDWGRLTGVAAATPRPDPEDG AG

SLPRIEDTLFALFRVPELLAPNGDLYHIFAWVLDVLADRLLPMHLFVLDYDQSPVGCRDALLRLTAGM

IP

TRVTTAGSIAEIRDLARTFAREVGGV*

gi | 125438 | sp | P04407 | KITH_HSV23 THYMIDINE KINASE

[ SEQ ID NO : 152 ] >contigl5 ( start 15005 - stop 16069 ) translated

VLRWDVRQGLGGPQHLPVSHRLGDVDDIVARPQGLHQLRGGGGLPHPVGSVYINPQQRGQLRIPAGF

GG PLAMARTGRRAAVGRPARTSSLTERRRVLLAGVRSHTRFYKAFAREVREFNATRICGTLLTLMSGSLQ

GR

SLFEATRVTLICEVDLGPRRPDCICVFEFANDKTLGGVCVILELKTCKSISSGDTASKREQRTTGMKQ

LR

HSLKLLQSLAPPGDKWYLCPILVFVAQRTLRVSRVTRLVPQKISGNITAAVRMLQSLSTYAVPPEPQ TR

RSRRRVAATARPQRPPSPTRDPEGTAGHPAPPESDPPSPGWGVAAEGGGVLQKIAALFCVPVAAKSR

PR

TKTE*

gi|136854|sp|P10208|UL24_HSVll PROTEIN UL24

[SEQ ID NO:153] >contigl5 (start 16350 - stop 18107) translated

MDPYYPFDALDVWEHRRFIVADSRSFITPEFPRDFWMLPVFNIPRETAAERAAVLQAQRTAAAAALEN

AA LQAAELPVDIERRIRPIEQQVHHIADALEALETAAAAAEEADAARDAEARGEGAADGAAPSPTAGPAA

AE

MEVQIVRNDPPLRYDTNLPVDLLHMVYAGRGAAGSSGWFGTWYRTIQERTIADFPLTTRSADFRDGR

MS

KTFMTALVLSLQSCGRLYVGQRHYSAFECAVLCLYLLYRTTHESSPDRDRAPVAFGDLLARLPRYLAR LA AVIGDESGRPQYRYRDDKLPKAQFAAAGGRYEHGALATHWIATLVRHGVLPAAPGDVPRDTSTRVNP

DD

VAHRDDVNRAAAAFLARGHNLFLWEDQTLLRATANTITALAVLRRLLANGNVYADRLDNRLQLGMLIP

GA

VPAEAIARGASGLDSGAIKSGDNNLEALCVNYVLPLYQADPTVELTQLFPGLAALCLDAQAGRPLAST

RR

WDMSSGARQAALVRLTALELINRTRTNTTPVGEIINAHDALGIQYEQGLGLLAQQARIGLASNAKRF

AT

FNVGSDYDLLYFLCLGFIPQYLSVA*

gi I 136863 | sp | P10209 | UL25_HSV11 VIRION PROTEIN UL25

[ SEQ ID NO : 154 ] >contigl5 ( start 18328 - stop 20256 ) translated

VRVPMASAEMRERLEAPLPDRAVPIYVAGFLALYDSGDPGELALDPDTVRAALPPENPLPINVDHRAR CE

VGRVLAWNDPRGPFFVGLIACVQLERVLETAASAAIFERRGPALSREERLLYLITNYLPSVSLSTKR

RG

DEVPPDRTLFAHVALCAIGRRLGTIVTYDTSLDAAIAPFRHLDPATREGVRREAAEAELALAGRTWAP

GV EALTHTLLSTAVNNMMLRDRWSLVAERRRQAGIAGHTYLQASEKFKIWGAESAPAPERGYKTGAPGAM

DT

SPAASVPAPQVAVRARQVASSSSΞSΞSFPAPADMNPVSASGAPAPPPPGDGSYLWIPAFHYNQLVTGQ

SA

PHHPPLTACGLPAAGTVAYGHPGAGPΞPHYPPPPAHPYPGMLFAGPSPLEAQIAALVGAIAADRQAGG LP

AAAGDHGIRGSAKRRRHEVEQPEYDCGRDEPDRDFPYYPGEARPEPRPVDSRRAARQASGPHETITAL

VG

AVTSLQQELAHMRARTHAPYGPYPPVGPYHHPHADTETPAQPPRYPAEAVYLPPPHIAPPGPPLSGAV

PP PSYPPVAVTPGPAPPLHQPSPAHAHPPPPPPGPTPPPAASLPQPEAPGAEAGALVNASSAAHVNVDTA

RA

ADLFVSQMMGSR*

>gi 1529230 UL26 [Herpes simplex virus type 1]

[SEQ ID NO: 155] = Contig 16 Length: 11707 Type: N Check: 605^

[SEQ ID NO:156] >contigl6 (start 190 - stop 2) translated MEAPGIVWVEESVSAITLYAVWLPPRTRDCLHALLYLVCRDAAGEARARFAEVSVGSSXXXXX

gi|l36802|sp|P10192|HEPA_HSVll DNA HELICASE/PRIMASE COMPLEX [ SEQ ID NO : 157 ] >contigl 6 ( start 2855 - stop 240 ) translated

MAETMNVATCTHQTHHAARAPGATSAPGAASGDPLGARRPIGDDECEQYTSSVSLARMLYGGDLAEWV

PR

VHPKTTIERQQHGPVTFPDASAPTARCVTVVRAPMGSGKTTALIRWLGEAIHSPDTSVLWSCRRSFT QT

LATRFAESGLPDFVTYFSSTNYIMNDRPFHRLIVQVESLHRVGPNLLNNYDVLVLDEVMSTLGQLYSP

TM

QQLGRVDALMLRLLRTCPRIIAMDATANAQLVDFLCSLRGEKNVHWIGEYAMPGFSARRCLFLPRLG

PE VLQAALRPPGPAGGAPPPDAPPDATFFGELEARLAGGDNVCIFSSTVSFAEWARFCRQFTDRVLLLH

SL

TPPGDVTTWGRYRWIYTTWTVGLSFDPPHFDSMFAYVKPMNYGPDMVSVYQSLGRVRTLRKGELLI

YM

DGSGARSEPVFTPMLLNHWSASGQWPAQFSQVTNLLCRRFKGRCDASHADAAQARGSRIYSKFRYKH F

ERCTLACLADSLNILHMLLTLNCMHVRFWGHDAALTPRNFCLFLRGIHFDALRAQRDLRELRCQDPDT

SL

SAQAAETEEVGLFVEKYLRPDVAPAEWALMRGLNSLVGRTRFIYLVLLEACLRVPMAAHSSAIFRRL

YD HYATGVIPTINAAGELELVALHPTLNVAPVWELFRLCSTMAACLQWDSMAGGSGRTFSPEDVLELLNP

HY

DRYMQLVFELGHCNVTDGPLLSEDAVKRVADALSGCPPRGSVSETEHALSLFKIIWGELFGVQLAKST

QT

FPGAGRVKNLTKRAIVELLDAHRIDHSACRTHRQLYALLMAHKREFAGARFKLRAPAWGRCLRTHASG AQ

PNTDIILEAALSELPTEAWPMMQGAVNFSTL*

gi I 136806 |sp|P10193 |OBP_HSVll ORIGIN OF REPLICATION BINDING

[SEQ ID NO: 158] >contigl6 (start 2707 - stop 4137) translated

VYCSHSSSPMGRRAPRGSPEAAPGADVAPGARAAWWVWCVQVATFIVSAICWGLLVLASVFRDRFPC

LY

APATSYAEANATVEVRGGVAVPLRLDTQSLLATYAITSTLLLAAAVYAAVGAVTSRYERALDAARRLA

AA RMAMPHATLIAGNVCAWLLQITVLLLAHRISQLAHLIYVLHFACLVYLAAHFCTRGVLSGTYLRQVHG

LI

DPAPTHHRIVGPVRAVMTNALLLGTLLCTAAAAVSLNTIAALNFNFSAPSMLICLTTLFALLWSLLL

W

EGVLCHYVRVLVGPHLGAIAATGIVGLACEHYHTGGYYWEQQWPGAQTGVRVALALVAAFALAMAVL RC

TRAYLYHRRHHTKFFVRMRDTRHRAHSALRRVRSSMRGSRRGGPPGDPGYAETPYASVSHHAEIDRYG

DS

DGDPIYDEVAPDHEAELYARVQRPGPVPDAEPIYDTVEGYAPRSAGEPVYSTVRRW*

gi|l36810|sp|P04288|VGLM_HSVll GLYCOPROTEIN [SEQ ID NO: 159] >contigl6 (start 4621 - stop 4331) translated MGLAFSGARPCCCRHNVIITDGGEWSLTAHEFDWDIESEEEGNFYVPPDMRWTRAPGPQYRRASD PP SRHTRRRDPDVARPPATLTPPLSDSE*

gi|136816|sp|P13294|ULll_HSV2 HYPOTHETICAL UL11 PROTEIN

[SEQ ID NO: 160] >contigl6 (start 6399 - stop 4537) translated MAAAATPGAKRPADPARDPDSPPKRPRPNSLDLATVFGPRPAPPRPTΞPGAPGSHWPQSPPRGQPDGG

AP

GEKARPASPALSEASSGPPTPDIPLSPGGAHAIDPDCSPGPPDPDPMWSASAIPNALPPHILAETFER

HL

RGLLRGVRSPLAIGPLWARLDYLCSLWSLEAAGMVDRGLGRHLWRLTRRAPPSAAEAVAPRPLMGFY EA

ATQNQADCQLWALLRRGLTTASTLRWGAQGPCFSSQWLTHNASLRLDAQSSAVMFGRVNEPTARNLLF

RY

CVGRADAGVNDDADAGRFVFHQPGDLAEENVHACGVLMDGHTGMVGASLDILVCPRDPHGYLAPAPQT

PL AFYEVKCRAKYAFDPADPGAPAASAYEDLMARRSPEAFRAFIRSIPNPGVRYFAPGRVPGPEEALVTQ

DR

DWLDSRAAGEKRRCSAPDRALVELNSGWSEVLLFGVPDLERRTISPVAWSSGELVRREPIFANPRHP

NF

KQILVQGYVLDSHFPDCPLQPHLVTFLGRHRAGAEEGVTFRLEDGRGAPAGRGGAPGPAKASILPDQA VP

IALIITPVRVEPGIYRDIRRNSRLAFDDTLAKLWASRSPGRGPAAADTTSSSPTAGRSSR*

gi|119694|sp|P06489|EXON_HSV2 ALKALINE EXONUCLEASE

[SEQ ID NO: 161] >contigl6 (start 8023 - stop 6440) translated

VGGRRPGGRMDESGRQRPASHVAADISPQGAHRRSFKAWLASYIHSLSRRASGRPSGPSPRDGAVSGA

RP

GSRRRSSFRERLRAGLSRWRVSRSSRRRSSPEAPGPAAKLRRPPLRRSETAMTSPPSPPSHILSLARI

HK LCIPVFAVNPALRYTTLEIPGARSFGGSGGYGEVQLIREHKLAVKTIREKEWFAVELVATLLVGECAL

RG

GRTHDIRGFITPLGFSLQQRQIVFPAYDMDLGKYIGQLASLRATTPSVATALHHCFTDLARAWFLNT

RC

GISHLDIKCANVLVMLRSDAVSLRRAVLADFSLVTLNSNSTISRGQFCLQEPDLESPRGFGMPAALTT AN

FHTLVGHGYNQPPELLVKYLNNERAEFNNRPLKHDVGLAVDLYALGQTLLELLVSVYVAPSLGVPVTR

VP

GYQYFNNQLSPDFAVALLAYRCVLHPALFVNSAETNTHGLAYDVPEGIRRHLRNPKIRRAFTEQCINY

QR THKAVLSSVSLPPELRPLLVLVSRLCHANPAARHSLS* gi|125628|sp|P04290|KR2_HSVll PROBABLE SERINE/THREONINE-PRO

[SEQ ID NO:162] >contigl6 ^"(start 8409 - stop 7750) translated MSRDASHAALRRRLAETHLRAEVYRDQTLQLHREGVSTQDPRFVGAFMAAKAAHLELEARLKSRARLE MM

RQRATCVKIRVEEQAARRDFLTAHRRYLDPALSERLDAADDRLADQEEQLEEAAANASLWGDGDLADG WM

SPGDSDLLVMWQLTSAPKVHTDAPSRPGSRPTYTPSAAGRPDAQAAPPPETAPSPEPAPGPAADPASG SG

FARDCPDGE*

gi 1136823 | sp | P042911 UL14_HSV11 HYPOTHETICAL UL14 PROTEIN

[SEQ ID NO:163] >contigl6 (start 8295 - stop 9788) translated

VYSRPPGVAAGSGPCTPRPGGASRPNVGAGPRGWRLGSSRRPRARPTSDSFAPTPLTSAAPASPAMFG

QQ

LASDVQQYLERLEKQRQQKVGVDEASAGLTLGGDALRVPFLDFATATPKRHQTWPGVGTLHDCCEHS

PL FSAVARRLLFNSLVPAQLRGRDFGGDHTAKLEFLAPELVRAVARLRFRECAPEDAVPQRNAYYSVLNT

FQ

ALHRSEAFRQLVHFVRDFAQLLKTSFRASSLAETTGPPKKRAKVDVATHGQTYGTLELFQKMILMHAT

YF

LAAVLLGDHAEQVNTFLRLVFEIPLFSDTAVRHFRQRATVFLVPRRHGKTWFLVPLIALSLASFRGIK IG

YTAHIRKATEPVFDEIDACLRGWFGSSRVDHVKGETISFSFPDGSRSTIVFASSHNTNVSTPSSRGAC

FP

GAALPEIDRQTNTARRECGTTRPQPPPPWRGEALLFICNRTMRLWPRPARPRGSSLQTGGWYTMTERR

GA TRRWSGG*

gi | 139646 | sp | P04295 | VTER_HSVll PROBABLE DNA PACKAGING PROTEIN

[ SEQ ID NO : 164 ] >contigl 6 ( start 10626 - stop 9661 ) translated VWRWRGDERLKIFRCLTVLTEPLCQVALPDPDPERALFCEIFLYLTRPKALRLPSNTFFAIFFFNRE RR

YCATVHLRSVTHPRTPLLCTLAFGHLEAASPPEETPDPAAEQLADEPVAHELDGAYLVPTEPPPNPGA CC ALGPGAWWHLPGGRIYCWAMDDDLGSLCPPGSRARHLGWLLSRITDPPGGGGACAPTAHIDSANALWR AP

AVAEACPCVAPCMWSNMAQRTLAVRGDASLCQLLFGHPVDAVILRQATRRPRITAHLHEWVGRDGAE

SV

IRPTSAGWRLCVLSSYTSRLFATSCPAVARAVARASSΞDYK*

gi| 136829 |sp|P10200|ULl6_HSVll PROTEIN UL16 [ SEQ ID NO : 165 ] >contigl 6 ( start 11723 - stop 10881 ) translated LTEACAAERWRPHQLSPAAQTALLRRFPALEGPLRHPRPVLQPFDIAAEVAFVARIQIACLRALGHS IR

AALQGGPRIFQRLRYDFGPHQSEWLGEVTRRFPVLLENLMRALEGTAPDAFFHTAYALAVLAHLGGQG GR

GRRRRLVPLSDDIPARFADSDAHYAFDYYSTSGDTLRLTNRPIAWIDGDVNGREQSKCRFMEGSPST AP

HRVCEQYLPGESYAYLCLGFNRRLCGLWFPGGFAFTINTAAYLSLADPVARAVGLRFCRGAATGPGL VR

gi I 136835 | sp | P10201 | UL17_HSV11 PROTEIN UL17

[SEQ ID NO:166] = Contig ID 17 Length: 732 Type: N Check: 3911

[SEQ ID NO: 167] >contigl7 (start 747 - stop 1) translated PAASPLEPLGDPTLWRALYACVLAALERQTGPVALFVPLRLGWDPQTGLWRVERASWGPPAAPRAAL

LD

VEAKVDVDPLALAARVAEHPGARLAWARLAAIRDSPQCASSASLAVTITTRTARFAREYTTLAFPPTS

KE

GAFADLVEVCEVGLRPRGHPQRVTARVLLPRGYDYFVSAGDGFSAPALVALFRQWHTTVHAAPGALAP VF

AFLGAGFDVRGGPVQYFAVLGFPGWPTFTVPAAAXXXXX

gi I 136802 | sp I P10192 I HEPA_HSV11 DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO:168] Contig ID 18 Length: 3006 Type: N Check: 6117 ..

[SEQ ID NO: 169] >contigl8 (start 2 - stop 673) translated XXXXXALEREQRAADRAAGGGAGRPAEADLLRADYDIIDVSKSMDDDTYVANSFQHQYIPAYGQDLER LS

RLWEHELVRCFKILRHRNNQGQETSISYSSGAIASFVAPYFEYVLRAPRAGALITGSDVILGEEELWE AV

FKKTRLQTYLTDVAALFVADVQHAALPRPPSPTPADFRASASPRGGSRSRTRTRSRSPGRTPRGAPDQ GW GVERRDGRPHARR* gi 1 136794 | sp | P10190 | UL06_HSV11 VIRION PROTEIN UL6

[SEQ ID NO: 170] >contigl8 (start 612 - stop 1538) translated VRRTRAGASNAGMADPTPADEGTAAAILKQAIAGDRSLVEVAEGISNQALLRMACEVRQVSDRQPRFT AT

SVLRVDVTPRGRLRFVLDGSSDDAYVASEDYFKRCGDQPTYRGFAVWLTANEDHVHSLAVPPLVLLH RL

SLFRPTDLRDFELVCLLMYLENCPRSHATPSLFVKVSAWLGWARHASPFERVRCLLLRSCHWILNTL MC

MAGVKPFDDELVLPHWYMAHYLLANNPPPVLSALFCATPQSSALQLPGPVPRTDCVAYNPAGVMGSCW KS KDLRSALVYWWLSGSPKRRTSSLFYRFC*

gi 1136798 | sp | P101911 UL07_HSV11 PROTEIN UL7

[SEQ ID NO: 171] >contigl8 (start 3021 - stop 1795) translated ACLGAWPAVGARWLPPRAWPAVASEAAGRLLPAFREAVARWHPTATTIQLLDPPAAVGPVWTARFCF SG

LQAQLLAALAGLGEAGLPEARGRAGLERLDALVAAAPSEPWARAVLERLVPDACDACPALRQLLGGVM AA

VCLQIEQTASSVKFAVCGGTGAAFWGLFNVDPGDADAAHGAIQDARRALEASVRAVLSANGIRPRLAP SL

ALEGVYTHWTWSQTGAWFWNSRDDTDFLQGFPLRGPAYAAAAEVMRDALRRILRRPAAGPPEEAVCA AR

GIMEDACDRFVLDAFGRRLDAEYWSVLTPPGEADDPLPQTAFRGGALLDAEQYWRRWRVCPGGGESV GV PVDLYPRPLVLPPVDCAHHLREILREIQLVFTGVLEGVWGEGGSFVYPFEEKMRFLFP*

gi 1136802 | sp | P10192 | HEPA_HSV11 DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO: 172] Contig ID 2 Length: 429 Type: N Check: 5672

[SEQ ID NO: 173] Contig ID 3 Length: 15901 Type: N Check: 1337 ..

[SEQ ID NO: 174] >contig3 (start 1547 - stop 2791) translated MADIPPDPPALNTTPANHAPPSPPPGSRKRRRPVLPSSSESEGKPDTESESSSTESSEDEAGDLRGGR

RR

SPRELGGRYFLDLSAESTTGTESEGTGPSDDDDDDASDGWLVDTPPRKSKRPRINLRLTSSPDRRAGV

VF

PEVWRNDRPIRAAQPQAPAQSSGDRAAAPRRSARQAQMRSGAAWTLDLHYIRQCVNQLFRILRAAPNP PG SANRLRHLVRDCYLMGYCRTRLGPRTWGRLLQISGGTWDVRLRNAIREVEARFEPAAEPVCELPCLNA RR

YGPECDVGNLETNGGSTSDDEISDATDSDDTLASHSDTEGGPSPAGRENPESASGGAIAARLECEFGT FD WTSEEGSQPWLSAWADTSSAERSGLPAPGACRATEAPEREDGCRKMRFPAACPYPCGHTFLRP*

gi I 124184 | sp| P04485 | IE68„HSV11 IMMEDIATE-EARLY PROTEIN IE68

[SEQ ID NO: 175] >contig3 (start 3848 - stop 2973) translated MGVVVVSVVTLLDQRNALPRTSADASPALWSFLLRQCRILASEPLGTPVVVRPANLRRLAEPLMDLPK FT

RPIVRTRSCRCPPNTTTGLFAEDDPLESIEILDAPACFRLLHQERPGPHRLYHLWWGAADLCVPFLE YA

QKTRLGFRFIAMKTNDAWVGEPWPLPDRFLPERTVSWTPFPAAPNHPLENLLSRYEYQYGVWPGDRE RS

CLRWLRSLVAPHNKPRPASSRPHPATHPTQRPCFTCMGRPEIPDEPSWQTGDDDPQNPGPPLAVGDEW

PP SSHVCYPITNL*

gi|137125|sp|P13292|US02_HSV2 PROTEIN US2

[SEQ ID NO: 176] >contig 3 (start 4044 - stop 5579) translated VGGCVDKLPLLKTPGPVARGARWLARATRRMACRKFCGVYRRPDKRQEASVPPETNTAPAFPASTFYT PA EDAYLAPGPPETIHPSRPPSPGEAARLCQLQEILAQMHΞDEDYPIVDAAGAEEEDEADDDAPDDVAYP ED

YAEGRFLSMVSAAPLPGASGHPPVPGRAAPPDVRTCDSGKVGATGFTPEELDTMDREALRAISRGCKP PS

TLAKLVTGLGFAIHGALIPGSEGCVFDSSHPNYPHRVIVKAGWYASTNHEARLLRRLNHPAILPLLDL HV

VSGVTCLVLPKYHCDLYTYLSKRPSPLGHLQITAVSRQLLSAIDYVHCEGIIHRDIKTENILINTPEN

IC

LGDFGAACFVRGCRSSPFHYGIAGTIDTNAPEVLAGDPYTQVIDIWSAGLVIFETAVHTASLFSAPRD PE RRPCDNQIARIIRQAQVHVDEFPTHAESRLTAHYRSRAAGNNRPAWTRPAWTRYYKIHTDVEYLICKA LT FDAALRPSAAELLRLPLFHPK*

gi|l25617|sp|P13287|KRl_HSV2 SERINE/THREONINE-PROTEIN KINASE

[SEQ ID NO: 177] >contig3 (start 8255 - stop 8368) translated VGGLCLMILGMACLLEVLRRLGRELARCCPHAGQFAP*

gi|l37132|sp|P13293 |VGLJ_HSV2 GLYCOPROTEIN J [SEQ ID NO: 178] >contig 3 (start 8791 - stop 9993) translated VCIAYHGMGRLTSGVGTAALLWAVGLRWCAKYALADPSLKMADPNRFRGKNLPVLDQLTDPPGVKR VY

HIQPSLEDPFQPPSIPITVYYAVLERACRSVLLHAPSEAPQIVRGAΞDEARKHTYNLTIAWYRMGDNC Al

PITVMEYTECPYNKSLGVCPIRTQPRWSYYDSFSAVSEDNLGFLMHAPAFETAGTYLRLVKINDWTEI TQ

FILEHRARASCKYALPLRIPPAACLTSKAYQQGVTVDSIGMLPRFIPENQRTVALYSLKIAGWHGPKP PY TSTLLPPELSDTTNATQPELVPEDPEDSALLEDPAGTVSSQIPPNWHIPSIQDVAPHHAPAAPSNPGL II GALAGSTLAVLVIGGIAFWVRRRAQMAPKRLRLPHIRDDDAPPSHQPLFY*

gi|l38234|sp|P03172|VGLD_HSV2 GLYCOPROTEIN D PRECURSOR

[SEQ ID NO: 179] >contig3 (start 10012 - stop 11313) translated

VYLWARVGGWLGYLGGTWTPHKGSLEGGKLGQFIGRERGARTAVPTISHRAHSHLDPSDPGMPGRΞLQ

GL

AILGLWVCATGLWRGPTVSLVSDSLVDAGAVGPQGFVEEDLRVFGELHFVGAQVPHTNYYDGIIELF HY

PLGNHCPRWHWTLTACPRRPAVAFTLCRSTHHAHSPAYPTLELGLARQPLLRVRTATRDYAGLYVL

RV

WVGSATNASLFVLGVALSANGTFVYNGSDYGSCDPAQLPFSAPRLGPSSVYTPGASRPTPPRTTTSPS

SP RDPTPAPGDTGTPAPASGERAPPNSTRSASESRHRLTVAQVIQIAIPASIIAFVFLGSCICFIHRCQR

RY

RRPRGQIYNPGGVSCAVNEAAMARLGAELRSHPNTPPKPRRRSSSSTTMPSLTSIAEESEPGPWLLS

VS

PRPRSGPTAPQEV*

gi|l38328|sp|P06764|VGLI_HSV23 GLYCOPROTEIN I

[SEQ ID NO: 180] >contig3 (start 11632 - stop 12984) translated

MARGAGLVFFVGVWWSCLAAAPRTSWKRVTSGEDWLLPAPAGPEERTRAHKLLWAAEPLDACGPLR PS

WVALWPPRRVLETWDAACMRAPEPLAIAYSPPFPAGDEGLYSELAWRDRVAWNESLVIYGALETDS

GL

YTLSWGLSDEARQVASWLWEPAPVPTPTPDDYDEEDDAGVSERTPVSVPPPTPPRRPPVAPPTHP

RV IPEVSHVRGVTVHMETPEAILFAPGETFGTNVSIHAIAHDDGPYAMDWWMRFDVPSSCAEMRIYEAC

LY

HPQLPECLSPADAPCAVSSWAYRLAVRSYAGCSRTTPPPRCFAEARMEPVPGLAWLASTVNLEFQHAS

PQ

HAGLYLCWYVDDHIHAWGHMTISTAAQYRNAWEQHLPQRQPEPVEPTRPHVRAPPPAPSARGPLRL GA VLGAALLLAALGLSAWGVHDLLAQALLAGG*

gi|138240|sp|P04488!VGLE_HSVll GLYCOPROTEIN E PRECURSOR

[SEQ ID NO:181] >contig3 (start 13431 - stop 13568) translated VALHAVDAPSQFVTWLAVRWLRGAVGLGAVLCGIAFYVTSIARGA*

gi|l944544|gnl|PID|e312381 US8A

[SEQ ID NO: 182] >contig3 (start 13668 - stop 13937) translated MTSRPADQDSVRSSASVPLYPAASPVPAEAYYSESEDEAANDFLVRMGRQQSVLRRRRRRTRCVGLVI AC LWALLSGGFGALLVWLLR*

gi|l35568|sp|P0648l|TEGP_HSVll TEGUMENT PHOSPHOPROTEIN US9

[SEQ ID NO:183] >contig3 (start 15333 - stop 14425) translated

MIRRRGNVEIRVYYESVRPSRSRSHLKPSDHQEFPGHHVSPGSPGFPESPGNREFHDLPENPGSRAYP

GT RDPHDPHGCPGSLDPHGNPAQPAGLPSPVPYAPLGSPDPSSPRQRTYVLPRVGIRNAPASDTRAPKRA

HS

RHRADRPPESPGSELYPLNAQALAHLQMLPADHRAFFRTVIEVSRLCALNTHDPPPPLAGARVGQEAQ

LV

HTQWLRANRESSPLWPWRTAAMNFIAAAAPCVQTHRHMHDLLMACAFWCCLAHASTCSYAGLYSAHCQ HL

FRAFGCGPPVLTTSRGQGGWCN*

gi|137138|sp|P06486|US10_HSVll VIRION PROTEIN US10

[SEQ ID NO: 184] = Contig ID 4 Length: 179 Type: N Check: 5124

[SEQ ID NO: 185] = Contig ID 5 Length: 2117 Type: N Check: 9467

[SEQ ID NO:186] >contig5 (start 1020 - stop 1) translated MLNDMQWLASSDSEEETEVGIΞDDDLHRDSTSEAGSTDTEMFEAGLMDAATPPARPPAERQGSPTPAD AQ

GSCGGGPVGEEEAEAGGGGDVCAVCTDEIAPPLRCQSFPCLHPFCIPCMKTWIPLRNTCPLCNTPVAY LI

VGVTASGSFSTIPIVNDPRTRVEAEAAVRSGTAVDFIWTGNPRTAPRSLSLGGHTVRALSPTPPWPGT DD EDDDLADGEGGRGSGTGRGSGTGRGSGTGRGSGTGRGSGGGRAGVGHWAGVGRGXGTNRGFPSLSPSA

AD

YVPPAPRRAPRRGGGGAGATRGTSQPAATRPAPPGAPRSSSSGGAPLRAGVGSGSXXXXX

gi|124135|sp|P28284|lCP0_HSV2H TRANS-ACTING TRANSCRIPTIONAL

[SEQ ID NO: 187] = Contig 6 Length: 643 Type: N Check: 5042

[SEQ ID NO:188] = Contig 7 Length: 354 Type: N Check: 9326

[SEQ ID NO: 189] = Contig 8 Length: 6387 Type: N Check: 4794

[SEQ ID NO: 190] >contig8 (start3 - stop 1454) translated

XXXXXTRRICARGPALPPGGLAVGGQMYVNRNEIFNAALAVTNIILDLDIALKEPVPFPRLHEALGHF

RR

GALAAVQLLFPAARVDPDAYPCYFFKSACRPRAPPVCAGDGPSAGGDDGDGDWFPDAGGDDGDEEWEE DT

DPMDTTHGPLPDDEAAYLDLLHEQIPAATPSEPDSWCSCADKIGLRVCLPVPAPYWHGSLTMRGVA

RV

IQQAVLLDRDFVEAVGSHVKNFLLIDTGVYAHGHSLRLPYFAKIGPDGSACGRLLPVFVIPPACEDVP

AF VAAHADPRRFHFHAPPMFSAAPREIRVLHSLGGDYVSFFEKKASRNALEHFGRRETLTEVLGRYDVRP

DA

GETVEGFASELLGRIVACIEAHFPEHAREYQAVSVRRAVIKDDWVLLQLIPGRGALNQSLSCLRFKHG

RA

SRATARTFLALSVGTNNRLCASLCQQCFATKCDNNRLHTLFTVDAGTPCSRSAPSSTSRPSSS*

gi|136939|sp|P10236|UL52_HSVll DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO: 191] >contig8 (start 1406 - stop 2422) translated MLAVRSLQHLTTVIFITAYGLVLAWYIVFGASPLHRCIYAVRPAGAHNDTALVWMKINQTLLFLGPPT AP

PGGAWTPHAHVCYANIIEGRAVSLPAIPGAMSRRVMNVHEAVNCLEALWDTQMRLVWGWFLYLAFVA LH

QRRCMFGWSPAHΞMVAPATYLLNYAGRIVSSVFLQYPYTKITRLLCELSVQRQTLVQLFEADPVTFL YH RPAVGVIVGCELLLRFVALGLIVGTALISRGACAITYPLFLTITTWCFVSIIALTELYFILRRDSAPK NA EPAAPRGRSKGWSGVCGRCCSIILSGIAVRLCYIAWAGWLMALRYEQEIQRRLFDL*

gi | 116105 | sp | P22485 | CELF_HSV2H CELL FUSION PROTEIN PRECURSOR [ SEQ ID NO : 192 ] >contig8 ( start 2752 - stop 4506 ) translated

VTPDGEGQGGVSESRPRSCGYKGSHRPTGRCVLPCADPGCASVPLLDSDPATLFRHAPPRRTPAIPAP

AT

YNMATDIDMLIDLGLDLSDSELEEDALERDEEGRRDDPESDSSGECSSSDEDMEDPCGDGGAEAIDAA IP

KGPPARPEDAGTPEASTPRPAARRGADDPPPATTGVWSRLGTRRSASPREPHGGKVARIQPPSTKAPH

PR

GGRRGRRRGRGRYGPGGADSTPNPRRRVSRNAHNQGGRHPASARTDGPGATHGEARRGGEQLDVSGGP

RP RGTRQAPPPLMALSLTPPHADGRAPVPERKAPSADTIDPAVRAVLRSISERAAVERISESFGRSALVM

QD

PFGGMPFPAANSPWAPVLATQAGGFDAETRRVSWETLVAHGPSLYRTFAANPRAASTAKAMRDCVLRQ

EN

LIEALASADETLAWCKMCIHHNLPLRPQDPIIGTAAAVLENLATRLRPFLQCYLKARGLCGLDDLCSR RR

LSDIKDIASFVLVILARLANRVERGVSEIDYTTVGVGAGETMHFYIPGACMAGLIEILDTHRQECSSR

VC

ELTASHTIAPLYVHGKYFYCNSLF*

gi 1124181 | sp | P28276 | IE63_HSV2H TRANSCRIPTIONAL REGULATOR IE

[SEQ ID NO:193] >contig8 (start 4638 - stop 5282) translated MWGPGPARFIARPGTHGRRVFTDPPPRNMTTTPLSNLFLRAPDITHVAPPYCLNATWQAENALHTTKT DP ACLAARSYLVRASCSTSGPIHCFFFAVYKDSQHSLPLVTELRNFADLVNHPPVLRELEDKRGGRLRCT GP

FSCGTIKDVSGASPAGEYTINGIVYHCHCRYPFSKTCWLGASAALQHLRSISSSGTAARAAEQRRHKI KI KIKV*

gi|136947|sp|P28281|UL55_HSV2H PROTEIN UL55

[SEQ ID NO: 194] >contig8 (start 5808 - stop 5455) translated MIGAHPGVGGDLPSGLPTYAEATSDRPPTYAMVMAACPTEPPGGSVGPADQPRVQSSRTWRPPLVNSR EL

YRAQRAARCASSSDTPQAPGWCGGTCRHAVFGWAWWIILAFLWR*

gi 1136952 | sp I P28282 |UL56_HSV2H PROTEIN UL56

[SEQ ID NO:195] = Contig 9 Length: 3700 Type: N Check: 8257 [SEQ ID NO:196] >contig9 (start 2 - stop 355) translated XXXXXGGHAAAGLTELCQTLAPRDLTDPLLFAYVGFQWNHGLMFWPDIAVYAMLGGAVWISLTQVL GL RRRLHKDPDAGPWAAATLRGLFFSVYALGFAAGVLVRPRMAASRRSG*

gi|136909|sp|P10227|UL43_HSVll MEMBRANE PROTEIN UL43

[SEQ ID NO: 197] >contig9 (start 453 - stop 2099) translated

MGAGVPWTGIKARGAGGPITVRVLGWEVAQKATHPCCSCPREAWSGNPPRCAGRAHRSFAGAGALLV MA

LGRVGLAVGLWGLLWVGVVVVLANASPGRTITVGPRGNASNAAPSASPRNASAPRTTPTPPQPRKATK

SK

ASTAKPAPPPKTGPPKTSSEPVRCNRHDPLARYGSRVQIRCRFPNSTRTESRLQIWRYATATDAEIGT

AP SLEEVMVNVSAPPGGQLVYDSAPNRTDPHVIWAEGAGPGASPRLYSWGPLGRQRLIIEELTLETQGM

YY

WVWGRTDRPSAYGTWVRVRVFRPPSLTIHPHAVLEGQPFKATCTAATYYPGNRAEFVWFEDGRRVFDP

AQ

IHTQTQENPDGFSTVSTVTSAAVGGQGPPRTFTCQLTWHRDSVSFSRRNASGTASVLPRPTITMEFTG DH

AVCTAGCVPEGVTFAWFLGDDSSPAEKVAVASQTSCGRPGTATIRSTLPVSYEQTEYICRLAGYPDGI

PV

LEHHGSHQPPPRDPTERQVIRAVEGAGIGVAVLVAWLAGTAWYLTHASSVRYRRLR*

gi|138220|sp|P06475|VGLC_HSV23 GLYCOPROTEIN C PRECURSOR

[SEQ ID NO: 198] >contig9 (start 2266 - stop 2847) translated VGSKRLRKRAPRPDIQARGGAMAFRASGPAYQPLAPAASPARARVPAVAWIGVGAIVGAFALVAALVL VP PRSSWGLSPCDSGWQEFNAGCVAWDPTPVEHEQAVGGCSAPATLIPRAAAKHLAALTRVQAERSSGYW V NGDGIRTCLRLVDSVSGIDEFCEELAIRICYYPRSPGGFVRFVTSIRNALGLP*

gi|136917|sp|P06483|UL45_HSV23 PROTEIN UL45 HOMOLOG

[SEQ ID NO:199] >contig9 (start 3716 - stop 3114) translated QRPAAAARPLAAQREAAGVYDAVRTWGPDAEAEPDQMENTYLLPDDDAAMPAGVGLGATPAADTTAAA WP

AESHAPRAPSEDADSIYESVSEDGGRVYEEIPWVRVYENICLRRQDAGGAAPPGDAPDSPYIEAENPL YD

WGGSALFSPPGATRAPDPGLSLSPMPARPRTNALANDGPTNVAALSALLTKLKRGRHQSH*

gi|114350|sp|P10230|ATI2_HSVll ALPHA TRANS-INDUCING FACTOR TABLE 3

[SEQ ID NO: 200] = Contig ID 2

[SEQ ID NO: 201] = Contig ID 3

[SEQ ID NO: 202] = Contig ID 4

[SEQ ID NO: 203] = Contig ID 5

[SEQ ID NO:204] = Contig ID 7

[SEQ ID NO: 205] = Contig ID 12

[SEQ ID NO: 206]

ORF # = 1 from Contig ID 12

ORF start site = 120

ORF end site = 1371

ORF sequence: MADIPPDPPALNTTPANHAPPSPPPGSRKRRRPVLPSSSESEGKPDTESESSSTESSEDEAGDLRGGR

RR

SPRELGGRYFLDLSAESTTGTESEGTGPSDDDDDDASDGWLVDTPPRKSKRPRINLRLTSSPDRRAGV

VF

PEVWRNDRPIRAAQPQAPAQSSGDRAAAPRRSARQAQMRΞGAAWTLDLHYIRQCVNQLFRILRAAPNP PG

SANRLRHLVRDCYLMGYCRTRLGPRTWGRLLQISGGTWDVRLRNAIREVEARFEPAAEPVCELPCLNA

RR

YGPECDVGNLETNGGSTSDDEISDATDSDDTLASHSDTEGGPSPAGRENPESASGGAIAARLECEFGT

FD WTSEEGSQPWLSAWADTSSAERSGLPAPGACRATEAPEREDGCRKMRFPAACPYPCGHTFLRP*

Gene matched : gi | 124184 | sp | P04485 | IE68_HSV11 Gene name : IMMEDIATE-EARLY PROTEIN IE68

[ SEQ ID NO : 207 ] ORF # = 2 from Contig 12 ORF start site = 2428 ORF end site = 1553 ORF sequence : MGWWSWTLLDQRNALPRTSADASPALWSFLLRQCRILASEPLGTPVWRPANLRRLAEPLMDLPK FT

RPIVRTRSCRCPPNTTTGLFAEDDPLESIEILDAPACFRLLHQERPGPHRLYHLWWGAADLCVPFLE YA

QKTRLGFRFIAMKTNDAWVGEPWPLPDRFLPERTVSWTPFPAAPNHPLENLLSRYEYQYGVWPGDRE RS

CLRWLRSLVAPHNKPRPASSRPHPATHPTQRPCFTCMGRPEIPDEPSWQTGDDDPQNPGPPLAVGDEW

PP

SSHVCYPITNL*

Gene matched: gi | 137125 | sp | P13292 |US02_HSV2 Gene name: PROTEIN US2 «gi | 419137 | pir | | A4

[SEQ ID NO:208]

ORF # 3 from Contig 12 ORF start site = 2714

ORF end site = 4159

ORF sequence :

MACRKFCGVYRRPDKRQEASVPPETNTAPAFPASTFYTPAEDAYLAPGPPETIHPSRPPSPGEAARLC

QL QEILAQMHSDEDYPIVDAAGAEEEDEADDDAPDDVAYPEDYAEGRFLSMVSAAPLPGASGHPPVPGRA

AP

PDVRTCDSGKVGATGFTPEELDTMDREALRAISRGCKPPSTLAKLVTGLGFAIHGALIPGSEGCVFDS

SH

PNYPHRVIVKAGWYASTNHEARLLRRLNHPAILPLLDLHWSGVTCLVLPKYHCDLYTYLSKRPSPLG HL

QITAVSRQLLSAIDYVHCEGIIHRDIKTENILINTPENICLGDFGAACFVRGCRSSPFHYGIAGTIDT

NA

PEVLAGDPYTQVIDIWSAGLVIFETAVHTASLFSAPRDPERRPCDNQIARIIRQAQVHVDEFPTHAES

RL TAHYRSRAAGNNRPAWTRPAWTRYYKIHTDVEYLICKALTFDAALRPSAAELLRLPLFHPK*

Gene matched: gi | 125617 | sp| P13287 | KR1_HSV2 Gene name: SERINE/THREONINE-PROTEIN KINAS

[SEQ ID NO: 209]

ORF # = 4 from Contig 12

ORF start site = 6835

ORF end site = 6948

ORF sequence : VGGLCLMILGMACLLEVLRRLGRELARCCPHAGQFAP* Gene matched: gi | 137132 | sp | P13293 |VGLJ_HSV2 Gene name: GLYCOPROTEIN J«gi | 419140 | pir |

[SEQ ID NO:210]

ORF # = 5 from Contig 12

ORF start site = 7392 ORF end site = 8573

ORF sequence:

MGRLTSGVGTAALLWAVGLRWCAKYALADPSLKMADPNRFRGKNLPVLDQLTDPPGVKRVYHIQPS

LE

DPFQPPSIPITVYYAVLERACRSVLLHAPSEAPQIVRGASDEARKHTYNLTIAWYRMGDNCAIPITVM EY

TECPYNKSLGVCPIRTQPRWSYYDSFSAVSEDNLGFLMHAPAFETAGTYLRLVKINDWTEITQFILEH

RA

RASCKYALPLRIPPAACLTSKAYQQGVTVDSIGMLPRFIPENQRTVALYSLKIAGWHGPKPPYTSTLL

PP ELSDTTNATQPELVPEDPEDSALLEDPAGTVSSQIPPNWHIPSIQDVAPHHAPAAPSNPGLIIGALAG

ST

LAVLVIGGIAFWVRRRAQMAPKRLRLPHIRDDDAPPSHQPLFY*

Gene matched: gi | 138234 | sp | P03172 |VGLD_HSV2 Gene name: GLYCOPROTEIN D PRECURSOR

[SEQ ID NO:211]

ORF # = 6 from Contig 12

ORF start site = 8775 ORF end site = 9893

ORF sequence :

MPGRSLQGLAILGLWVCATGLWRGPTVSLVSDSLVDAGAVGPQGFVEEDLRVFGELHFVGAQVPHTN Y

DGIIELFHYPLGNHCPRWHWTLTACPRRPAVAFTLCRSTHHAHSPAYPTLELGLARQPLLRVRTAT RD

YAGLYVLRVWVGSATNASLFVLGVALSANGTFVYNGSDYGSCDPAQLPFSAPRLGPSSVYTPGASRPT

PP

RTTTSPSSPRDPTPAPGDTGTPAPASGERAPPNSTRSASESRHRLTVAQVIQIAIPASIIAFVFLGSC

IC FIHRCQRRYRRPRGQIYNPGGVSCAVNEAAMARLGAELRSHPNTPPKPRRRSSSSTTMPΞLTSIAEES

EP

GPWLLSVSPRPRSGPTAPQEV*

Gene matched: gi | 138328 | sp | P06764 |VGLI_HSV23 Gene name: GLYCOPROTEIN I^ΛAgi | 73722 | pir | [ SEQ ID NO : 212 ]

ORF # = 7 from Contig 12 ORF start site = 10212

ORF end site = 11858

ORF sequence :

MARGAGLVFFVGVWVVSCLAAAPRTSWKRVTSGEDVVLLPAPAGPEERTRAHKLLWAAEPLDACGPLR

PS WVALWPPRRVLETWDAACMRAPEPLAIAYSPPFPAGDEGLYSELAWRDRVAWNESLVIYGALETDS

GL

YTLSWGLSDEARQVASWLWEPAPVPTPTPDDYDEEDDAGVSERTPVSVPPPTPPRGPPVAPPTHP

RV

IPEVSHVRGVTVHMETPEAILFAPGETFGTNVSIHAIAHDDGPYAMDWWMRFDVPSSCAEMRIYEAC LY

HPQLPECLSPADAPCAVSSWAYRLAVRSYAGCSRTTPPPRCFAEARMEPVPGLAWLASTVNLEFQHAS

PQ

HAGLYLCWYVDDHIHAWGHMTISTAAQYRNAWEQHLPQRQPEPVEPTRPHVRAPPPAPSARGPLRL

GA VLGAALLLAALGLSAWACMTCWRRRSWRAVKSRASATGPTYIRVADSELYADWSΞDSEGERDGSLWQD

PP

ERPDSPSTNGSGFEILSPTAPSVYPHSEGRKSRRPLTTFGSGSPGRRHSQASYSSVLW*

Gene matched: gi | 138240 | sp | P04488 |VGLE_HSV11 Gene name: GLYCOPROTEIN E PRECURSOR

[SEQ ID NO: 213] ORF # = 8 from Contig 12 ORF start site = 12010 ORF end site = 12147 ORF sequence: VALHAVDAPSQFVTWLAVRWLRGAVGLGAVLCGIAFYVTSIARGA*

Gene matched: gi | 1944544 | gnl | PID| e312381 Gene name: (X14112) US8A [human herpesvirus

[SEQ ID NO:214]

ORF # = 9 from Contig 12 ORF start site = 12247 ORF end site = 12516 ORF sequence: MTSRPADQDS VRS SAS VPLYP AAS PVPAEAYYS E S EDEAANDFLVRMGRQQ S VLRRRRRRTRCVGLVI

AC

LWALLSGGFGALLVWLLR*

Gene matched: gi | 135568 | sp | P06481 |TEGP_HSV11 Gene name: TEGUMENT PHOSPHOPROTEIN US9

[SEQ ID NO:215]

ORF # = 10 from Contig 12

ORF start site = 13912

ORF end site = 13004

ORF sequence : MIRRRGNVEIRVYYESVRPSRSRSHLKPSDHQEFPGHHVSPGSPGFPESPGNREFHDLPENPGSRAYP

GT

RDPHDPHGCPGSLDPHGNPAQPAGLPSPVPYAPLGSPDPSSPRQRTYVLPRVGIRNAPASDTRAPKRA

HS

RHRADRPPESPGSELYPLNAQALAHLQMLPADHRAFFRTVIEVSRLCALNTHDPPPPLAGARVGQEAQ LV

HTQWLRANRESSPLWPWRTAAMNFIAAAAPCVQTHRHMHDLLMACAFWCCLAHASTCSYAGLYSAHCQ

HL

FRAFGCGPPVLTTSRGQGGWCN*

Gene matched: gi | 137138 | sp | P06486 |US10_HSV11 Gene name: VIRION PROTEIN US10

[SEQ ID NO: 216]

ORF # = 11 from Contig 12

ORF start site = 15899

ORF end site = 16582

ORF sequence: MSAEQRKKKKTTTTTQGRGAEVAMADEDGGRLRAAAETTGGPGSPDPADGPPPTPNPDRRPAARPGFG

WH

GGPEENEDEDDDAAADADADEAAPASGEAVDEPAADGWSPRQLALLASMVDEAVRTIPSPPPERDGA

EE

EAARSPSPPRTPSMCADYGEENDDDDDDDDRDAGRWVRGPENDVRGPRGVPGPHGQPVAATPGAPPTP PP

PPPPPPPARPPPALDRL*

Gene matched: gi | 124141 | sp | P08392 | ICP4_HSV11 Gene name: TRANS-ACTING TRANSCRIPTIONAL [SEQ ID NO: 217] = Contig ID 15

[SEQ ID NO:218]

ORF # = 1 from Contig 15

ORF start site = 755

ORF end site = 1297 ORF sequence:

MRTPADDVSWRYEAPSVIDYARIDGIFLRYHCPGLDTFLWDRHAQRAYLVNPFLFAAGFLEDLSHSVF

PA

DTQETTTRRALYKEIRDALGSRKQAVSHAPVRAGCVNFDYSRTRRCVGRRDLRPANTTSTWEPPVSSD

DE ASSQSKPLATQPPVLALSNAPPRRVSPTRGRRRHTRLRRN*

Gene matched: gi | 136776 | sp| P28278 |VGLL_HSV2H Gene name: GLYCOPROTEIN L PRECURSOR»gi |

[SEQ ID NO:219]

ORF # = 2 from contig 15

ORF start site = 1170 ORF end site = 2174

ORF sequence:

MKRARSRSPSPPSRPSSPFRTPPHGGSPRREVGAGILASDATSHVCIASHPGSGAGYPTRLAAGSAVQ

RR

RPRGCPPGVMFSASTTPEQPLGLΞGDATPPLPTSVPLDWAAFRRAFLIDDAWRPLLEPELANPLTARL LA

EYDRRCQTEEVLPPREDVFSWTRYCTPDDVRWIIGQDPYHHPGQAHGLAFSVRADVPVPPSLRNVLA

AV

KNCYPDARMSGRGCLEKWARDGVLLLNTTLTVKRGAAASHSKLGWDRFVGGWRRLAARRPGLVFMLW

GA HAQNAIRPDPRQHYVLKFSHPSPLSKVPFGTCQHFLAANRYLETRDIMPIDWSV*

Gene matched: gi | 137037 | sp | P10186 |UNG_HSV11 Gene name: URACIL-DNA GLYCOSYLASE

[SEQ ID NO: 220] ORF # = 3 from Contig 15 ORF start site = 2229 ORF end site = 2930 ORF sequence:

MVKSRVSYRSVMSGVGEERVPSAFTILASWGWTFAPQNHDPGASPNTTPIESIAGTAPDAHVGPLDGE PD

RDAISPLTSSVAGDPPGADGPYVTFDTLFMVSSIDELGRRQLTDTIRKDLRLSLAKFSIACTKTSSFS GT

AARQRKRGAPPQRTCVPRSNKSLQMFVLCKRANAAQVREQLRAVIRSRKPRKYYTRSSDGRLCPAVPV

FV

HEFVSSEPMRLHRDNVMLSTEPD*

Gene matched: gi | 136782 | sp| P28279 |UL03_HSV2H Gene name: PROTEIN UL3

[SEQ ID NO:221]

ORF # = 4 from contig 15

ORF start site = 3735

ORF end site = 3130

ORF sequence : MGNPQTTIAYSLHHPRASLTSALPDAAQWHVFESGTRAVLTRGRARQDRLPRGGWIQHTPIGLLVI

ID

CRAEFCAYRFIGRASTQRLERWWDAHMYAYPFDSWVSSSHGESVRSATAGILTWWTPDTIYITATIY

GT

APEAARGCDNAPLDVRPTTPPAPVSPTAGEFPANTTDLLVEVLREIQISPTLDDADPTPGT*

Gene matched: gi | 136788 | sp | P28280 | UL04_HSV2H Gene name: PROTEIN UL4«gi | 73890 |pir | | WM

[SEQ ID NO:222]

ORF # = 5 from Contig 15

ORF start site = 6447

ORF end site = 3802 ORF sequence :

MAASGGEGSRDVRAPGPPPQQPGARPAVRFRDEAFLNFTSMHGVQPIIARIRELSQQQLDVTQVPRLQ

WF

RDVAALEVPTGLPLREFPFAAYLITGNAGSGKSTCVQTLNEVLDCVVTGATRIAAQNMYVKLSGAFLS

RP INTIFHEFGFRGNHVQAQLGQHPYTLASSPASLEDLQRRDLTYYWEVILDITKRALAAHGGEDARNEF

HA

LTALEQTLGLGQGALTRLASVTHGALPAFTRSNIIVIDEAGLLGRHLLTTWYCWWMINALYHTPQYA

GR

LRPVLVCVGSPTQTASLESTFEHQKLRCSVRQSENVLTYLICNRTLREYTRLSHSWAIFINNKRCVEH EF GNLMKVLEYGLPITEEHMQFVDRFWPESYITNPANLPGWTRLFSSHKEVSAYMAKLHAYLKVTREGE FV

VFTLPVLTFVSVKEFDEYRRLTQQPTLTMEKWITANASRITNYSQSQDQDAGHVRCEVHSKQQLWAR ND ITYVLNSQVAVTARLRKMVFGFDGTFRTFEAVLRDDSFVKTQGETSVEFAYRFLSRLMFGGLIHFYNF LQ

RPGLDATQRTLAYGRLGELTAELLSLRRDAAGASATRAADTSDRSPGERAFNFKHLGPRDGGPDDFPD DD LDVIFAGLDEQQLDVFYCHYALEEPETTAAVHAQFGLLKRAFLGRYLILRELFGEVFESAPFSTYVDN

FRGCELLTGSPRGGLMΞVALQTDNYTLMGYTYTRVFAFAEELRRRHATAGVAEFLEESPLPYIVLRDQ HG

FMSWNTNISEFVESIDSTELAMAINADYGISSKLAMTITRSQGLSLDKVAICFTPGNLRLNSAYVAM SR TTSSEFLHMNLNPLRERHERDDVISEHILSALRDPNWIVY*

Gene matched : gi | 122809 | sp | P10189 | HELI_HSV11 Gene name : PROBABLE HELICASE

[ SEQ ID NO : 223 ]

ORF # = 7 from Contig 15

ORF start site = 8457 ORF end site = 9347

ORF sequence:

MADPTPADEGTAAAILKQAIAGDRSLVEVAEGISNQALLRMACEVRQVSDRQPRFTATSVLRVDVTPR

GR

LRFVLDGSSDDAYVASEDYFKRCGDQPTYRGFAVWLTANEDHVHSLAVPPLVLLHRLSLFRPTDLRD FE

LVCLLMYLENCPRSHATPSLFVKVSAWLGWARHASPFERVRCLLLRSCHWILNTLMCMAGVKPFDDE

LV

LPHWYMAHYLLANNPPPVLSALFCATPQSSALQLPGPVPRTDCVAYNPAGVMGSCWKSKDLRSALVYW

WL SGSPKRRTSSLFYRFC*

Gene matched: gi | 136798 | sp | P10191 |UL07_HSV11 Gene name: PROTEIN UL7

[SEQ ID NO: 224]

ORF # = 8 from Contig 15 ORF start site = 11855 ORF end site = 9604 ORF sequence: MEAPGIVWVEESVSAITLYAVWLPPRTRDCLHALLYLVCRDAAGEARARFAEVSVGSSDLQDFYGSPD

VS

AAGAVAAARAAPAASPLEPLGDPTLWRALYACVLAALERQTGPVALFVPLRLGWDPQTGLWRVERAS

WG PPAAPRAALLDVEAKVDVDPLALAARVAEHPGARLAWARLAAIRDSPQCASSASLAVTITTRTARFAR

EY

TTLAFPPTSKEGAFADLVEVCEVGLRPRGHPQRVTARVLLPRGYDYFVSAGDGFSAPALVALFRQWHT

TV

HAAPGALAPVFAFLGPGFEVRGGPVQYFAVLGFPGWPTFTVPAAAAAESARDLVRGAAATHAACLGAW PA

VGARWLPPRAWPAVASEAAGRLLPAFREAVARWHPTATTIQLLDPPAAVGPVWTARFCFSGLQAQLL

AA

LAGLGEAGLPEARGRAGLERLDALVAAAPSEPWARAVLERLVPDACDACPALRQLLGGVMAAVCLQIE

QT ASSVKFAVCGGTGAAFWGLFNVDPGDADAAHGAIQDARRALEASVRAVLSANGIRPRLAPSLALEGVY

TH

WTWSQTGAWFWNSRDDTDFLQGFPLRGPAYAAAAEVMRDALRRILRRPAAGPPEEAVCAARGIMEDA

CD

RFVLDAFGRRLDAEYWSVLTPPGEADDPLPQTAFRGGALLDAEQYWRRWRVCPGGGESVGVPVDLYP RP

LVLPPVDCAHHLREILREIQLVFTGVLEGVWGEGGSFVYPFEEKMRFLFP*

Gene matched: gi | 136802 | sp | P10192 |HEPA_HSV11 Gene name: DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO:225]

ORF # = 10 from Contig 15

ORF start site = 14399 ORF end site = 15802

ORF sequence :

MGRRAPRGSPEAAPGADVAPGARAAWWVWCVQVATFIVSAICWGLLVLASVFRDRFPCLYAPATSYA

EA

NATVEVRGGVAVPLRLDTQSLLATYAITSTLLLAAAVYAAVGAVTSRYERALDAARRLAAARMAMPHA TL

IAGNVCAWLLQITVLLLAHRISQLAHLIYVLHFACLVYLAAHFCTRGVLSGTYLRQVHGLIDPAPTHH

RI

VGPVRAVMTNALLLGTLLCTAAAAVSLNTIAALNFNFSAPSMLICLTTLFALLWSLLLWEGVLCHY

VR VLVGPHLGAIAATGIVGLACEHYHTGGYYWEQQWPGAQTGVRVALALVAAFALAMAVLRCTRAYLYH

RR

HHTKFFVRMRDTRHRAHSALRRVRSSMRGSRRGGPPGDPGYAETPYASVSHHAEIDRYGDSDGDPIYD

EV

APDHEAELYARVQRPGPVPDAEPIYDTVEGYAPRSAGEPVYSTVRRW* Gene matched : gi | 136810 | sp | P04288 | VGLM_HSV11 Gene name : GLYCOPROTEIN M

[SEQ ID NO: 226]

ORF # = 11 from Contig 15 ORF start site = 16286 ORF end site = 15996 ORF sequence : MGLAFSGARPCCCRHNVIITDGGEWSLTAHEFDWDIESEEEGNFYVPPDMRWTRAPGPQYRRASD PP SRHTRRRDPDVARPPATLTPPLSDSE*

Gene matched: gi | 136816 | sp | P13294 | UL11_HSV2 Gene name: HYPOTHETICAL UL11 PROTEIN

[SEQ ID NO: 227] ORF # = 12 from Contig 15

ORF start site = 18064

ORF end site = 16202

ORF sequence:

MAAAATPGAKRPADPARDPDΞPPKRPRPNSLDLATVFGPRPAPPRPTSPGAPGSHWPQSPPRGQPDGG AP

GEKARPASPALSEASΞGPPTPDIPLSPGGAHAIDPDCSPGPPDPDPMWSASAIPNALPPHILAETFER

HL

RGLLRGVRSPLAIGPLWARLDYLCSLWSLEAAGMVDRGLGRHLWRLTRRAPPSAAEAVAPRPLMGFY

EA ATQNQADCQLWALLRRGLTTASTLRWGAQGPCFSSQWLTHNASLRLDAQSSAVMFGRVNEPTARNLLF

RY

CVGRADAGVNDDADAGRFVFHQPGDLAEENVHACGVLMDGHTGMVGASLDILVCPRDPHGYLAPAPQT

PL

AFYEVKCRAKYAFDPADPGAPAASAYEDLMARRSPEAFRAFIRSIPNPGVRYFAPGRVPGPEEALVTQ DR

DWLDSRAAGEKRRCSAPDRALVELNSGWSEVLLFGVPDLERRTISPVAWSSGELVRREPIFANPRHP

NF

KQILVQGYVLDSHFPDCPLQPHLVTFLGRHRAGAEEGVTFRLEDGRGAPAGRGGAPGPAKASILPDQA

VP IALIITPVRVEPGIYRDIRRNSRLAFDDTLAKLWASRSPGRGPAAADTTSSSPTAGRSSR*

Gene matched: gi | 119694 | sp | P06489 | EXON_HSV2 Gene name: ALKALINE EXONUCLEASE«gi | 33025 [SEQ ID NO:228]

ORF # = 13 from Contig 15

ORF start site = 19661 ORF end site = 18107

ORF sequence:

MDESGRQRPASHVAADISPQGAHRRSFKAWLASYIHSLSRRASGRPSGPSPRDGAVSGARPGSRRRSS

FR

ERLRAGLSRWRVSRSSRRRSSPEAPGPAAKLRRPPLRRSETAMTSPPSPPSHILSLARIHKLCIPVFA VN

PALRYTTLEIPGARSFGGSGGYGEVQLIREHKLAVKTIREKEWFAVELVATLLVGECALRGGRTHDIR

GF

ITPLGFSLQQRQIVFPAYDMDLGKYIGQLASLRATTPSVATALHHCFTDLARAWFLNTRCGISHLDI

KC ANVLVMLRSDAVSLRRAVLADFSLVTLNSNSTISRGQFCLQEPDLESPRGFGMPAALTTANFHTLVGH

GY

NQPPELLVKYLNNERAEFNNRPLKHDVGLAVDLYALGQTLLELLVSVYVAPSLGVPVTRVPGYQYFNN

QL

SPDFAVALLAYRCVLHPALFVNSAETNTHGLAYDVPEGIRRHLRNPKIRRAFTEQCINYQRTHKAVLS SV

SLPPELRPLLVLVSRLCHANPAARHSLS*

Gene matched: gi | 125628 | sp | P04290 | KR2_HSV11

Gene name: PROBABLE SERINE/THREONINE-PROTEIN KINASE

[SEQ ID NO:229]

ORF # = 14 from Contig 15

ORF start site = 20074 ORF end site = 19415

ORF sequence :

MSRDASHAALRRRLAETHLRAEVYRDQTLQLHREGVSTQDPRFVGAFMAAKAAHLELEARLKSRARLE

MM

RQRATCVKIRVEEQAARRDFLTAHRRYLDPALSERLDAADDRLADQEEQLEEAAANASLWGDGDLADG WM

SPGDSDLLVMWQLTSAPKVHTDAPSRPGSRPTYTPSAAGRPDAQAAPPPETAPSPEPAPGPAADPASG

SG

FARDCPDGE*

Gene matched: gi | 136823 | sp| P04291 |UL14_HSV11 Gene name: HYPOTHETICAL UL14 PROTEIN

[SEQ ID NO:230; ORF # = 15 from Contig 15

ORF start site = 20155

ORF end site = 21453

ORF sequence: MFGQQ

LASDVQQYLERLEKQRQQKVGVDEASAGLTLGGDALRVPFLDFATATPKRHQTWPGVGTLHDCCEHS

PL

FSAVARRLLFNSLVPAQLRGRDFGGDHTAKLEFLAPELVRAVARLRFRECAPEDAVPQRNAYYSVLNT

FQ ALHRSEAFRQLVHFVRDFAQLLKTSFRASSLAETTGPPKKRAKVDVATHGQTYGTLELFQKMILMHAT

YF

LAAVLLGDHAEQVNTFLRLVFEIPLFSDTAVRHFRQRATVFLVPRRHGKTWFLVPLIALSLASFRGIK

IG

YTAHIRKATEPVFDEIDACLRGWFGSSRVDHVKGETISFSFPDGSRSTIVFASSHNTNVSTPSSRGAC FP

GAALPEIDRQTNTARRECGTTRPQPPPPWRGEALLFICNRTMRLWPRPARPRGSSLQTGGWYTMTERR

GA

TRRWSGG*

Gene matched : gi 1 139646 | sp | P04295 | VTER_HSV11 Gene name : PROBABLE DNA PACKAGING PROTEIN

[ SEQ ID NO : 231 ] ORF # = 16 from Contig 15

ORF start s ite = 22291

ORF end site = 21326

ORF sequence :

VWRWRGDERLKIFRCLTVLTEPLCQVALPDPDPERALFCEIFLYLTRPKALRLPSNTFFAIFFFNRE RR

YCATVHLRSVTHPRTPLLCTLAFGHLEAASPPEETPDPAAEQLADEPVAHELDGAYLVPTEPPPNPGA

CC

ALGPGAWWHLPGGRIYCWAMDDDLGSLCPPGSRARHLGWLLSRITDPPGGGGACAPTAHIDSANALWR

AP AVAEACPCVAPCMWSNMAQRTLAVRGDASLCQLLFGHPVDAVILRQATRRPRITAHLHEVWGRDGAE

SV

IRPTSAGWRLCVLSSYTSRLFATSCPAVARAVARASSSDYK*

Gene matched: gi | 136829 | sp | P10200 |UL16_HSV11 Gene name: PROTEIN UL16

[SEQ ID NO:232] ORF # = 17 from Contig 15 ORF start site = 24654

ORF end site = 22546

ORF sequence:

MNAHFANEVQYDLTRDPSSPASLIHVIISSECLAAAGVPLSALVRGRPDGGAAANFRVETQTRAHATG DC

TPWRSAFAAYVPADAVGAILAPVIPAHPDLLPRVPSAGGLFVSLPVACDAQGVYDPYTVAALRLAWGP

WA

TCARVLLFSYDELVPPNTRYAADGARLMRLCRHFCRYVARLGAAAPAAATEAAAHLSLGMGESGTPTP

QA SSVSGGAGPAWGTPDPPISPEEQLTAPGGDTATAEDVSITQENEEILALVQRAVQDVTRRHPVRARP

KH

AASGVASGLRQGALVHQAVSGGALGASDAEAVLAGLEPPGGGRFATPGGPRAAGEDVLNDVLTLVPGT

AK

PRSLVEWLDRGWEALAGGDRPDWLWSRRSISWLRHHYGTKQRFVWSYENSVAWGGRRARPPRLSSE LA

TALTEACAAERWRPHQLSPAAQTALLRRFPALEGPLRHPRPVLQPFDIAAEVAFVARIQIACLRALG

HS

IRAALQGGPRIFQRLRYDFGPHQSEWLGEVTRRFPVLLENLMRALEGTAPDAFFHTAYALAVLAHLGG

QG GRGRRRRLVPLSDDIPARFADSDAHYAFDYYΞTSGDTLRLTNRPIAWIDGDVNGREQSKCRFMEGSP

ST

APHRVCEQYLPGESYAYLCLGFNRRLCGLWFPGGFAFTINTAAYLSLADPVARAVGLRFCRGAATGP

GL

VR*

Gene matched: gi | 136835 | sp | P10201 |UL17_HSV11 Gene name: PROTEIN UL17

[SEQ ID NO:233]

ORF # = 18 from Contig 15

ORF start site = 24684

ORF end site = 25955 ORF sequence:

VPEGAWVGGACARPRGPRAHVRLYAVCFVCPQGIRGQDFNLLFVDEANFIRPDAVQTIMGFLNQANCK

II

FVSSTNTGKASTSFLYNLRGAADELLNWTYICDDHMPRWTHTNATACSCYILNKPVFITMDGAVRR

TA DLFLPDSFMQEIIGGQARETGDDRPVLTKSAGERFLLYRPSTTTNSGLMAPELYVYVDPAFTANTRAS

GT

GIAWGRYRDDFIIFALEHFFLRALTGSAPADIARCWHSLAQVLALHPGAFRSVRVAVEGNSSQDSA

VA

IATHVHTEMHRILASAGANGPGPELLFYHCEPPGGAVLYPFFLLNKQKTPAFEYFIKKFNSGGVMASQ EL VSVTVRLQTDPVEYLSEQLNNLIETVSPNTDVRMYSGKRNGAADDLMVAVIMAIYLAAPTGIPPAFFP

IT

RTS*

Gene matched: gi | 139646 | sp| P04295 |VTER_HSV11 Gene name: PROBABLE DNA PACKAGING PROTEIN

[SEQ ID NO:234] ORF # = 19 from Contig 15

ORF start site = 27251

ORF end site = 26295

ORF sequence:

MITDCFEADIAIPSGISRPDAAALQRCEGRWFLPTIRRQLALADVAHESFVSGGVSPDTLGLLLAYR RR

FPAVITRVLPTRIVACPVDLGLTHAGTVNLRNTSPVDLCNGDPVSLVPPVFEGQATDVRLESLDLTLR

FP

VPLPTPLAREIVARLVARGIRDLNPDPRTPGELPDLNVLYYNGARLSLVADVQQLASVNTELRSLVLN

MV YSITEGTTLILTLIPRLLALSAQDGYVNALLQMQSVTREAAQLIHPEAPMLMQDGERRLPLYEALVAW

LA

HAGQLGDILALAPAVRVCTFDGAAWQSGDMAPVIRYP*

Gene matched: gi | 139191 | sp| P10202 |VP23_HSV11 Gene name: CAPSID PROTEIN VP23

[SEQ ID NO:235]

ORF # = 21 from Contig 15 ORF start site = 32735

ORF end site = 32067

ORF sequence:

MTMRDDVPLLDRELVYEAACGGEDGELPLDEQFSLSSYGTSDFFVSSAYSRLPPHTQPVFSKRWMFA

WS FLVLKPLELVAAGMYYGWTGRAVAPACIIAAVLAYYVTWLARALLLYVNIKRDRLPLSPPVFWGLCVI

MG

GAALCALVAAAHETFSPDGLFHWITASQLLPRTDPLRARSLGIACAAGAAMWVAAADCFAAFTNFFLA

RF

WTRAILKAPVAF*

Gene matched: | 136841 | sp| P10204 |UL20_HSV11 Gene name: MEMBRANE PROTEIN UL20 [SEQ ID NO:236]

ORF # = 23 from Contig 15

ORF start site = 37721

ORF end site = 35205 ORF sequence:

MGPGLWWMGVLVGVAGGHDTYWTEQIDPWFLHGLGLARTYWRDTNTGRLWLPNTPDASDPQRGRLAP

PG

ELNLTTASVPMLRWYAERFCFVLVTTAEFPRDPGQLLYIPKTYLLGRPRNASLPELPEAGPTSRPPAE

VT QLKGLSHNPGASALLRSRAWVTFAAAPDREGLTFPRGDDGATERHPDGRRNAPPPGPPAGTPRHPTTN

LS

IAHLHNASVTWLAARGLLRTPGRYVYLSPSASTWPVGVWTTGGLAFGCDAALVRARYGKGFMGLVISM

RD

SPPAEIIWPADKTLARVGNPTDENAPAVLPGPPAGPRYRVFVLGAPTPADNGSALDALRRVAGYPEE ST

NYAQYMSRAYAEFLGEDPGSGTDARPSLFWRLAGLLASSGFAFVNAAHAHDAIRLSDLLGFLAHSRVL

AG

LAARGAAGCAADSVFLNVSVLDPAARLRLEARLGHLVAAILEREQSLAAHALGYQLAFVLDSPAAYGA

VA PSAARLIDALYAEFLGGRALTAPMVRRALFYATAVLRAPFLAGAPSAEQRERARRGLLITTALCTSDV

AA

ATHADLRAALARTDHQKNLFWLPDHFSPCAASLRFDLAEGGFILDALAMATRSDIPADVMAQQTRGVA

SV

LTRWAHYNALIRAFVPEATHQCSGPSHNAEPRILVPITHNASYWTHTPLPRGIGYKLTGVDVRRPLF IT

YLTATCEGHAREIEPKRLVRTENRRDLGLVGAVFLRYTPAGEVMSVLLVDTDATQQQLAQGPVAGTPN

VF

SSDVPSVALLLFPNGTVIHLLAFDTLPIATIAPGFLAASALGWMITAALAGILRWRTCVPFLWRRE

Gene matched: gi | 138315 | sp | P06477 |VGLH_HSV11 Gene name: GLYCOPROTEIN H PRECURSOR

[SEQ ID NO:237]

ORF # = 24 from Contig 15

ORF start site = 39188

ORF end site = 38058

ORF sequence : MASHAGQQHAPAFGQAARASGPTDGRAASRPSHRQGASEARGDPELPTLLRVYIDGPHGVGKTTTSAQ

LM

EALGPRDNIVYVPEPMTYWQVLGASETLTNIYNTQHRLDRGEISAGEAAWMTSAQITMSTPYAATDA

VL

APHIGGEAVGPQAPPPALTLVFDRHPIASLLCYPAARYLMGSMTPQAVLAFVALMPPTAPGTNLVLGV LP EAEHADRLARRQRPGERLDLAMLSAIRRVYDLLANTVRYLQRGGRWREDWGRLTGVAAATPRPDPEDG AG

SLPRIEDTLFALFRVPELLAPNGDLYHIFAWVLDVLADRLLPMHLFVLDYDQSPVGCRDALLRLTAGM IP TRVTTAGSIAEIRDLARTFAREVGGV*

Gene matched: gi | 125438 | sp | P04407 | KITH_HSV23 Gene name: THYMIDINE KINASE

[SEQ ID NO:238] ORF # = 25 from Contig 15 ORF start site = 39090 ORF end site = 39935 ORF sequence :

MARTGRRAAVGRPARTSSLTERRRVLLAGVRSHTRFYKAFAREVREFNATRICGTLLTLMSGSLQGRS LF EATRVTLICEVDLGPRRPDCICVFEFANDKTLGGVCVILELKTCKSISSGDTASKREQRTTGMKQLRH SL

KLLQSLAPPGDKWYLCPILVFVAQRTLRVSRVTRLVPQKISGNITAAVRMLQSLSTYAVPPEPQTRR SR

RRVAATARPQRPPSPTRDPEGTAGHPAPPESDPPSPGWGVAAEGGGVLQKIAALFCVPVAAKSRPRT KT E*

Gene matched: gi | 136854 | sp | P10208 | UL24_HSV11 Gene name: PROTEIN UL24

[SEQ ID NO: 239]

ORF # = 26 from Contig 15

ORF start site = 40216

ORF end site = 41973 ORF sequence:

MDPYYPFDALDVWEHRRFIVADSRSFITPEFPRDFWMLPVFNIPRETAAERAAVLQAQRTAAAAALEN

AA

LQAAELPVDIERRIRPIEQQVHHIADALEALETAAAAAEEADAARDAEARGEGAADGAAPSPTAGPAA

AE MEVQIVRNDPPLRYDTNLPVDLLHMVYAGRGAAGSSGWFGTWYRTIQERTIADFPLTTRSADFRDGR

MS

KTFMTALVLSLQSCGRLYVGQRHYSAFECAVLCLYLLYRTTHESSPDRDRAPVAFGDLLARLPRYLAR

LA

AVIGDESGRPQYRYRDDKLPKAQFAAAGGRYEHGALATHWIATLVRHGVLPAAPGDVPRDTSTRVNP DD VAHRDDVNRAAAAFLARGHNLFLWEDQTLLRAT ANT I TALAVLRRLLANGNVYADRLDNRLQLGML I P GA

VPAEAIARGASGLDSGAIKSGDNNLEALCVNYVLPLYQADPTVELTQLFPGLAALCLDAQAGRPLAST RR WDMSSGARQAALVRLTALELINRTRTNTTPVGEIINAHDALGIQYEQGLGLLAQQARIGLASNAKRF AT FNVGSDYDLLYFLCLGFIPQYLSVA*

Gene matched : gi | 136863 | sp | P10209 | UL25_HSV11 Gene name : VIRION PROTEIN UL25

[ SEQ ID NO : 240 ]

ORF # = 27 from Contig 15 ORF start site = 42206

ORF end s ite = 44179

ORF sequence :

MASAEMRERLEAPLPDRAVPIYVAGFLALYDSGDPGELALDPDTVRAALPPENPLPINVDHRARCEVG

RV LAWNDPRGPFFVGLIACVQLERVLETAASAAIFERRGPALSREERLLYLITNYLPSVSLSTKRRGDE

VP

PDRTLFAHVALCAIGRRLGTIVTYDTSLDAAIAPFRHLDPATREGVRREAAEAELALAGRTWAPGVEA

LT

HTLLSTAVNNMMLRDRWSLVAERRRQAGIAGHTYLQASEKFKIWGAESAPAPERGYKTGAPGAMDTSP AA

SVPAPQVAVRARQVASSSSSSSSFPAPADMNPVSASGAPAPPPPGDGSYLWIPAFHYNQLVTGQSAPH

HP

PLTACGLPAAGTVAYGHPGAGPSPHYPPPPAHPYPGMLFAGPSPLEAQIAALVGAIAADRQAGGLPAA

AG DHGIRGSAKRRRHEVEQPEYDCGRDEPDRDFPYYPGEARPEPRPVDSRRAARQAΞGPHETITALVGAV

TS

LQQELAHMRARTHAPYGPYPPVGPYHHPHADTETPAQPPRYPAEAVYLPPPHIAPPGPPLSGAVPPPS

YP

PVAVTPGPAPPLHQPSPAHAHPPPPPPGPTPPPAASLPQPEAPGAEAGALVNASSAAHVKRGHGPGRR SV

CVTDDGVPLTRLQDPDLGGVCVFIYFK*

Gene matched: gi | 139233 | sp| P10210 |VP40_HSV11 Gene name: CAPSID PROTEIN P40 (VIRION S

[SEQ ID NO:241] ORF # = 28 from Contig 15 ORF start site = 47298 ORF end site = 44584 ORF sequence :

MRGGGLICALWGALVAAVASAAPAAPAAPRASGGVAATVAANGGPASRPPPVPSPATTKARKRKTKK

PP

KRPEATPPPDANATVAAGHATLRAHLREIKVENADAQFYVCPPPTGATWQFEQPRRCPTRPEGQNYT EG

IAWFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINAKGVCRSTAKY

VR

NNMETTAFHRDDHETDMELKPAKVATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYP

YD EFVLATGDFVYMSPFYGYREGSHTEHTSYAADRFKQVDGFYARDLTTKARATΞPTTRNLLTTPKFTVA

WD

WVPKRPAVCTMTKWQEVDEMLRAEYGGSFRFSSDAISTTFTTNLTQYSLSRVDLGDCIGRDAREAIDR

MF

ARKYNATHIKVGQPQYYLATGGFLIAYQPLLSNTLAELYVREYMREQDRKPRNATPAPLREAPSANAS VE

RIKTTSSIEFARLQFTYNHIQRHVNDMLGRIAVAWCELQNHELTLWNEARKLNPNAIASATVGRRVSA

RM

LGDVMAVSTCVPVAPDNVIVQNSMRVSSRPGTCYSRPLVSFRYEDQGPLIEGQLGENNELRLTRDALE

PC TVGHRRYFIFGGGYVYFEEYAYSHQLSRADVTTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLD

YT

EVQRRNQLHDLRFADIDTVIRADANAAMFAGLCAFFEGMGDLGRAVGKWMGWGGWSAVSGVSSFM

SN

PFGALAVGLLVLAGLVAAFFAFRYVLQLQRNPMKALYPLTTKELKTSDPGGVGGEGEEGAEGGGFDEA KL

AEAREMIRYMALVSAMERTEHKARKKGTSALLSSKVTNMVLRKRNKARYSPLHNEDEAGDEDEL*

Gene matched : gi | 138198 | sp | P06763 | VGLB_HSV23 Gene name : GLYCOPROTEIN B PRECURSOR • gi |

[ SEQ ID NO : 242 ] ORF # = 29 from Contig 15 ORF start site = 47122 ORF end site = 47338 ORF sequence :

WAGLGTGGGREAGPPFAATVAATPPEARGAAGAAGAADATAATSAPTTSAQIKPPPRMAGLRGRVAP AA R*

Gene matched: gi | 729379 | sp| P39055 | DYN1_CAEEL Gene name: DYNAMIN«gi | 456286 (L29031) d [SEQ ID NO: 243]

ORF # = 30 from Contig 15

ORF start site = 49662 ORF end site = 47305

ORF sequence :

MAAAPPAAVSEPTAARQKLLALLGQVQTYVFQLELLRRCDPQIGLGKLAQLKLNALQVRVLRRHLRPG

LE

AQAAAFLTPLSVTLELLLEYAWREGERLLGHLETFATTGDVSAFFTETMGLARPCPYHQQIRLETYGG DV

RMELCFLHDVENFLKQLNYCHLITPPSGATAALERVREFMVAAVGSGLIVPPELSDPSHPCAVCFEEL

CV

TANQGATIARRLADRICNHVTQQAQVRLDANELRRYLPHAAGLSDAARARALCVLDQALARTAAGGGA

RA GPPPADSSSVREEADALLEAHDVFQATTPGLYAISELRFWLASGDRARHSTMDAFADNLNALAQRELQ

QE

TAAVAVELALFGRRAEHFDRAFGGHLAALDMVDALIIGGQATSPDDQIEALIRACYDHHLTTPLLRRL

VS

PEQCDEEALRRVLARLGAGGATGGAEEEEPRAAAEEGGRRRGAGTPASEDGERGPEPGAQGPESWGDI AT

RAAADVPERRRLYADRLTKRSLASLGRCVREQRGELEKMLRVSVHGEVLPATFAAVANGFAARARFCA

LT

AGAGTVIDNRAAPGVFDAHRFMRASLLRHQVDPALLPSITHRFFELVNGPLFDHSTHΞFAQPPNTALY

YS VENVGLLPHLKEELARFIMGAGGSGADWAVSEFQKFYCFDGVSGITPTQRAAWRYIRELIIATTLFAS

VY

RCGELELRRPDCSRPTSEGLYRYPPGVYLTYNSDCPLVAIVESGPDGCIGPRSVWYDRDVFSILYSV

LQ

HLAPRLAGGGSDAPP*

Gene matched: gi | 124088 | sp | P10212 | PRTP_HSV11 Gene name: PROCESSING AND TRANSPORT PRO

[SEQ ID NO:244] ORF # = 31 from Contig 15 ORF start site = 51666 ORF end site = 50035 ORF sequence:

MSLSLDPYTCGPCPLLQLLARRSNLAVYQDLALSQCHGVFAGQSVEGRNFRNQFQPVLRRRVMDLFNN GF

LSAKTLTVALSEGAAICAPSLTAGQTAPAESSFEGDVARVTLGFPKELRVKSRVLFAGASANASEAAK AR VASLQSAYQKPDKRVDILLGPLGFLLKQFHAVIFPNGKPPGSNQPNPQWFWTALQRNQLPARLLSRED IE

TIAFIKRFSLDYGAINFINLAPNNVSELAMYYMANQILRYCDHSTYFINTLTAVIAGSRRPPGVQAAA AW APQGGAGLEAGARALMDSLDAHPGAWTSMFASCNLLRPVMAARPMWLGLSISKYYGMAGNDRVFQAG NW

ASLLGGKNACPLLIFDRTRKFVLACPRAGFVCAASSLGGGAHEHSLCEQLRGIIAEGGAAVASSVFVA TV

KSLGPRTQQLQIEDWLALLEDEYLSEEMMEFTTRALERGHGEWSTDAALEVAHEAEALVSQLGAAGEV FN

FGDFGDEDDHAASFGGLAAAAGAAGVARKRAFHGDDPFGEGPPEKKDLTLDML*

Gene matched: gi | 544182 | sp | P36384 | DNBI_HSV2 Gene name: MAJOR DNA-BINDING PROTEIN (IN

[SEQ ID NO: 245]

ORF # = 32 from Contig 15 ORF start site = 53575

ORF end site = 51701

ORF sequence:

MDTKPKTTTTVKVPPGPMGYVYGRACPAEGLELLSLLSARSGDADVAVAPLIVGLTVESGFEANVAAV

VG SRTTGLGGTAVSLKLMPSHYSPSVYVFHGGRHLAPSTQAPNLTRLCERARRHFGFSDYAPRPCDLKHE

TT

GDALCERLGLDPDRALLYLVITEGFREAVCISNTFLHLGGMDKVTIGDAEVHRIPVYPLQMFMPDFSR

VI

ADPFNCNHRSIGENFNYPLPFFNRPLARLLFEAWGPAAVALRARNVDAVARAAAHLAFDENHEGAAL PA

DITFTAFEASQGKPQRGARDAGNKGPAGGFEQRLASVMAGDAALALESIVSMAVFDEPPPDITTWPLL

EG

QETPAARAGAVGAYLARAAGLVGAMVFSTNSALHLTEVDDAGPADPKDHSKPSFYRFFLVPGTHVAAN PQ LDREGHWPGYEGRPTAPLVGGTQEFAGEHLAMLCGFSPALLAKMLFYLERCDGGVIVGRQEMDVFRY VA

DSGQTDVPCNLCTFETRHACAHTTLMRLRARHPKFASAARGAIGVFGTMNSAYSDCDVLGNYAAFSAL KR ADGSENTRTIMQETYRAATERVMAELEALQYVDQAVPTALGRLETIIGTREALHTWNNIKQLV*

Gene matched: >gi | 544182 | sp| P36384 | DNBI_HSV2 Gene name: MAJOR DNA-BINDING PROTEIN (IN [SEQ ID NO:246]

ORF # = 33 from Contig 15

ORF start site = 54393

ORF end site = 58115 ORF sequence:

MFCAAGGPTSPGGKSAARAASGFFAPHNPRGATQTAPPPCRRQNFYNPHLAQTGTQPKAPGPAQRHTY

YS

ECDEFRFIAPRSLDEDAPAEQRTGVHDGRLRRAPKVYCGGDERDVLRVGPEGFWPRRLRLWGGADHAP

EG FDPTVTVFHVYDILEHVEHAYSMRAAQLHERFMDAITPAGTVITLLGLTPEGHRVAVHVYGTRQYFYM

NK

AEVDRHLQCRAPRDLCERLAAALRESPGASFRGISADHFEAEWERADVYYYETRPTLYYRVFVRSGR

AL

AYLCDNFCPAIRKYEGGVDATTRFILDNPGFVTFGWYRLKPGRGNAPAQPRPPTAFGTSSDVEFNCTA DN

LAVEGAMCDLPAYKLMCFDIECKAGGEDELAFPVAERPEDLVIQISCLLYDLSTTALEHILLFSLGSC

DL

PESHLSDLASRGLPAPWLEFDSEFEMLLAFMTFVKQYGPEFVTGYNIINFDWPFVLTKLTEIYKVPL

DG YGRMNGRGVFRVWDIGQSHFQKRSKIKVNGMVNIDMYGIITDKVKLSSYKLNAVAEAVLKDKKKDLSY

RD

IPAYYASGPAQRGVIGEYCVQDSLLVGQLFFKFLPHLELSAVARLAGINITRTIYDGQQIRVFTCLLR

LA

GQKGFILPDTQGRFRGLDKEAPKRPAVPRGEGERPGDGNGDEDKDDDEDGDEDGDEREEVARETGGRH VG

YQGARVLDPTSGFHVDPVWFDFASLYPSIIQAHNLCFSTLSLRPEAVAHLEADRDYLEIEVGGRRLF

FV

KAHVRESLLSILLRDWLAMRKQIRSRIPQSTPEEAVLLDKQQAAIKWCNSVYGFTGVQHGLLPCLHV

AA TVTTIGREMLLATRAYVHARWAEFDQLLADFPEAAGMRAPGPYSMRIIYGDTDSIFVLCRGLTAAGLV

AM

GDKMASHISRALFLPPIKLECEKTFTKLLLIAKKKYIGVICGGKMLIKGVDLVRKNNCAFINRTSRAL

VD

LLFYΌDTVΞGAAAALAERPAEEWLARPLPEGLQAFGAVLVDAHRRITDPERDIQDFVLTAELSRHPRA YT

NKRLAHLTVYYKLMARRAQVPSIKDRIPYVIVAQTREVEETVARLAALRELDAAAPGDEPAPPAALPS

PA

KRPRETPSHADPPGGASKPRKLLVSELAEDPGYAIARGVPLNTDYYFSHLLGAACVTFKALFGNNAKI

TE SLLKRFIPETWHPPDDVAARLRAAGFGPAGAGATAEETRRMLHRAFDTLA*

Gene matched: gi | 118882 | sp | P07918 |DPOL_HSV21 Gene name: DNA POLYMERASE [SEQ ID NO: 247]

ORF # = 34 from Contig 15

ORF start site = 58977 ORF end site = 58060

ORF sequence:

MYDIAPRRSGSRPGPGRDKTRRRSRFSAAGNPGVERRASRKSLPSHARRLELCLHERRRYRGFFAALA

QT

PSEEIAIVRSLSVPLVKTTPVSLPFSLDQTVADNCLTLSGMGYYLGIGGCCPACSAGDGRLATVSREA LI

LAFVQQINTIFEHRTFLASLWLADRHSTPLQDLLADTLGQPELFFVHTILRGGGACDPRFLFYPDPT

YG

GHMLYVIFPGTSAHLHYRLIDRMLTACPGYRFAAHVWQSTFVLVVRRNAEKPADAEIPTVSAADIYCK

MR DISFDGGLMLEYQRLYATFDEFPPP*

Gene matched: gi | 136875 | sp | P10215 |UL31_HSV11 Gene name: PROTEIN UL31

[SEQ ID NO:248]

ORF # = 35 from Contig 15

ORF start site = 60760

ORF end site = 58970 ORF sequence :

MATSAPGVPSSAAVREESPGSSWKEGAFERPYVAFDPDLLALNEALCAELLAACHWGVPPASALDED

VE

SDVAPAPPRPRGAAREASGGRGPGSARGPPADPTAEGLLDTGPFAAASVDTFALDRPCLVCRTIELYK

QA YRLSPQWVADYAFLCAKCLGAPHCAASIFVAAFEFVYVMDHHFLRTKKATLVGSFARFALTINDIHRH

FF

LHCCFRTDGGVPGRHAQKQPRPTPSPGAAKVQYSNYSFLAQSATRALIGTLASGGDDGAGAGGGSGTQ

PS

LTTALMNWKDCARLLDCTEGKRGGGDSCCTRAAARNGEFEAAAGALAQGGEPETWAYADLILLLLAGT PA

VWESGPRLRAAADARRAAVSESWEAHRGARMRDAAPRFAQFAEPKAQPDLDLGPLMATVLKHGRGRGR

TG

GECLLCNLLLVRAYWLAMRRLRASWRYSENNTSLFDCIVPWDQLEADPEAQPGDGGRFVSLLRAAG

PE AIFKHMFCDPMCAITEMEVDPWVLFGHPRADHRDELQLHKAKLACGNEFEGRVCIALRALIYTFKTYQ

VF

VPKPTALATFVREAGALLRRHSISLLSLEHTLCTYV*

Gene matched: gi | 136879 | sp | P10216 |UL32_HSV11 Gene name: PROBABLE MAJOR ENVELOPE GLYC [SEQ ID NO:249] ORF # = 36 from Contig 15 ORF start site = 60759 ORF end site = 61151 ORF sequence:

MAGRAGRTRPRTLRDAIPDCALRSQTLESLDARYVSRDGAGDAAVWFEDMTPAELEVIFPTTDAKLNY LS RTQRLASLLTYAGPIKAPDGPAAPHTQDTACVHGELLARKRERFAAVINRFLDLHQILRG*

Gene matched: gi | 136883 | sp | P10217 |UL33_HSV11 Gene name : UL33

[SEQ ID NO:250]

ORF # = 37 from Contig 15

ORF start site = 61241 ORF end site = 62071

ORF sequence:

MAGMGKPYGGRPGDAFEGLVQRIRLIVPTTLRGGGGEΞGPYSPSNPPSRCAFQFHGQDGSDEAFPIEY

VL

RLMNDWADVPCNPYLRVQNTGVSVLFQGFFNRPHGAPGGAITAEQTNVILHSTETTGLSLGDLDDVKG RL

GLDARPMMASMWISCFVRMPRVQLAFRFMGPEDAVRTRRILCRAAEQALARRRRSRRSQDDYGAVAVA

AA

HHSSGAPGPGVAASGPPAPPGRGPARPWHQAVQLFRAPRPGPPALLLLVAGLFLGAAIWWAVGARL*

Gene matched: gi | 136888 | sp | P10218 |UL34_HSV11 Gene name: VIRION PROTEIN UL34

[SEQ ID NO: 251]

ORF # = 38 from Contig 15

ORF start site = 62183

ORF end site = 62521

ORF sequence: MAAPQFHRPSTITADNVRALGMRGLVLATNNAQFIMDNSYPHPHGTQGAVREFLRGQAAALTDLGVTH

AN

NTFAPQPMFAGDAAAEWLRPSFGLKRTYSPFWRDPKTPSTP*

Gene matched: gi | 139196 | sp| P10219 |VP26_HSV11 Gene name : CAPSID PROTEIN VP26

ID [ SEQ ID NO : 252 ] ORF # = 39 from Contig 15

ORF start s ite = 72047

ORF end site = 62688

ORF sequence :

MIPAALPHPTMKRQGDRDIWTGVRNQFATDLEPGGSVSCMRSSLSFLSLLFDVGPRDVLSAEAIEGC LV

EGGEWTRAAAGSGPPRMCSIIELPNFLEYPAARGGLRCVFSRVYGEVGFFGEPTAGLLETQCPAHTFF

AG

PWAMRPLSYTLLTIGPLGMGLYRDGDTAYLFDPHGLPAGTPAFIAKVRAGDVYPYLTYYAHDRPKVRW

AG AMVFFVPSGPGAVAPADLTAAALHLYGASETYLQDEPFVERRVAITHPLRGEIGGLGALFVGWPRGD

GE

GSGPWPALPAPTHVQTPRADRPPEAPRGASGPPNTPQAGHPNRPPDDVWAAALEGTPPAKPSAPDAA

AS

GPPHAAPPPQTPAGDAAEEAEDLRVLEVGAVPVGRHRARYSTGLPKRRRPTWTPPSSVEDLTSGERPA PK

APPAKAKKKSAPKKKAPVAAEVPASSPTPIAATVPPAPDTPPQSGQGGGDDGPASPSSPSVLETLGAR

RP

PEPPGADLAQLFEVHPNVAATAVRLAARDAALAREVAACSQLTINALRSPYPAHPGLLELCVIFFFER VL AFLIENGARTHTQAGVAGPAAALLDFTLRMLPRKTAVGDFLASTRMSLADVAAHRPLIQHVLDENSQI GR

LALAKLVLVARDVIRETDAFYGDLADLDLQLRAAPPANLYARLGEWLLERSRAHPNTLFAPATPTHPE PL

LHRIQALAQFARGEEMRVEAEAREMREALDALARGVDSVSQRAGPLTVMPVPAAPGAGGRAPCPPALG PE

AIQARLEDVRIQARRAIESAIKEYFHRGAVYSAKALQASDSHDCRFHVASAAWPMVQLLESLPAFDQ

HT

RDVAQRAALPPPPPLATSPQAILLRDLLQRGQTLDAPEDLAAWLSVLTDAATQGLIERKPLEELARSI

HG INDQQARRSSGLAELQRFDALDAALAQQLDSDAAFVPATGPAPYVDGGGLSPEATRMAEDALRQARAM

EA

AKMTAELAPEARSRLRERAHALEAMLNDARERAKVAHDAREKFLHKLQGVLRPLPDFVGLKACPAVLA

TL

RASLPAGWTDLADAVRGPPPEVTAALRADLWGLLGQYREALEHPTPDTATALAGLHPAFVWLKTLFA DA

PETPVLVQFFSDHAPTIAKAVSNAINAGSAAVATASPAATVDAAVRAHGALADAVSALGAAARDPASP

LS

FLAALADSAAGYVKATRLALEARGAIDELTTLGSAAADLWQARRACAQPEGDHAALIDAAARATTAA

RE SLAGHEAGFGGLLHAEGTAGDHSPSGRALQELGKVIGATRRRADELEAAVADLTAKMAAQRARGSSER

WA

AGVEAALDRVENRAEFDWELRRLQALAGTHGYNPRDFRKRAEQALAANAEAVTLALDTAFAFNPYTP

EN QRHPMLPPLAAIHRLGWSAAFHAAAETYADMFRVDAEPLARLLRIAEGLLEMAQAGDGFIDYHEAVGR

LA

DDMTSVPGLRRYVPFFQHGYADYVELRDRLDAIRADVHRALGGVPLDLAAAAEQISAARNDPEATAEL

VR

TGVTLPCPSEDALVACAAALERVDQSPVKNTAYAEYVAFVTRQDTAETKDAVVRAKQQRAEATERVMA GL

REALAARERRAQIEAEGLANLKTMLKWAVPATVAKTLDQARSVAEIADQVEVLLDQTEKTRELDVPA

VI

WLEHAQRTFETHPLSAARGDGPGPLARHAGRLGALFDTRRRVDALRRSLEEAEAEWDEVWGRFGRVRG

GA WKSPEGFRAMHEQLRALQDTTNTVSGLRAQPAYERLSARYQGVLGAKGAERAEAVEELGARVTKHTAL

CA

RLRDEWRRVPWEMNFDALGRLLAEFDAAAADLAPWAVEEFRGARELIQRRMGLYSAYARAGGQTGAG

AA

AAPAPLLVDLRALDARARASSSPEGHEVDPQLLRRRGEAYLRAGGDPGPLVLREAVSALDLPFATSFL AP

DGTPLQYALCFPAVTDKLGALLMRPEAACVRPPLPTDVLESAPTVTAMYVLTWNRLQLALSDAQAAN

FQ

LFGRFVRHRQATWGASMDAAAELYVALVATTLTREFGCRWAQLGWASGAAAPRPPPGPRGSQRHCVAF

NE NDVLVALVAGVPEHIYNFWRLDLVRQHEYMHLTLERAFEDAAESMLFVQRLTPHPDARIRVLPTFLDG

GP

PTRGLLFGTRLADWRRGKLSETDPLAPWRSALELGTQRRDAPALGKLSPAQALAAVSVLGRMCLPSAA

LA

ALWTCMFPDDYTEYDSFDALLAARLESGQTLGPAGGREASLPEAPHALYRPTGQHVAVLAAATHRTPA AR

VTAMDLVLAAVLLGAPVWALRNTTAFSRESELELCLTLFDSRPGGPDAALRDWSSDIETWAVGLLH

TD

LNPIENACLAAQLPRLSALIAERPLADGPPCLVLVDISMTPVAVLWEAPEPPGPPDVRFVGSEATEEL

PF VATAGDVLAASAADADPFFARAILGRPFDASLLTGELFPGHPVYQRPLADEAGPΞAPTAARDPRDLAG

GD

GGSGPEDPAAPPARQADPGVLAPTLLTDATTGEPVPPRMWAWIHGLEELASDDAGGPTPNPAPALLPP

PA

TDQSVPTSQYAPRPIGPAATARETRPSVPPQQNTGRVPVAPRDDPRPSPPTPSPPADAALPPPAFSGS AA

AFSAAVPRVRRSRRTRAKSRAPRASAPPEGWRPPALPAPVAPVAASARPPDQPPTPESAPPAWVSALP

LP

PGPASARGAFPAPTLAPIPPPPAEGAVAPGDDRRRGRRQTTAGPSPTPPRGPAAGPPRRLTRPAVASL

SA SLNSLPSPRDPADHAAAVSAAAAAVPPSPGLAPPTSAVQTSPPPLAPGPVAPSEPLCGWWPGGPVAR

RP

PPQSPATKPAARTRIRARSVPQPPLPQPPLPQPPLPQPPLPQPPLPQPPLPQPPLPQPPLPQPPLPQP

PL

PQPPLPQPPLPQSRDSVPTPESPTHTNTHLPVSAVTSWASSLALHVDSAPPPASLLQTLHISSDDEHS

DA

DSLRFSDSDDTEALDPLPPEPHLPPADEPPGPLAADHLQSPHSQFGPLPVQANAVLSRRYVRSTGRSA

LA

VLIRACRRIQQQLQRTRRALFQRSNAVLTSLHHVRMLLG*

Gene matched: gi | 135576 | sp | P10220 |TEGU_HSV11 Gene name: LARGE TEGUMENT PROTEIN (VIRI

[SEQ ID NO: 253]

ORF # = 40 from Contig 15

ORF start site = 75699

ORF end site = 72355

ORF sequence: MSDSALQVPAPAGMTPPSAPPPNGPLQVLLGSLTNLRRPPSPSSEPAGSADEPAFLSAAKLRAATAAF

LL

SGAAVGPAEARACWHPLLEQLCALHRAHGLPETALLAENLPGLLVHRMAVALPETPEAAFREMDVIKD

TV

LAITGSDTTHALEAAGLRTTAALGPVRVRQCAVEWIDRWRTVTQSCLAMNPRTSLEALGEMSLKMSPV PL

GQPGANLTTPAYΞLLFPSPIVQEGLRFLALVSNWVTLFSAHLQRIDDAALTPLTRALFTLALVDEYLT

TP

DRGAWPPPLLAQFQHTVREIDPAIMIPPLEATKMVRSREEVRVSTALSRVSPRSACAPPGTLMARVR

TD AAVFDPDVPFLSASALAIFRPAVTGLLQLGEPPSAGAQQRLLALLQQTWALVQNSNSPSWINTLTDA

GF

TPAHCTQYISALEGFLVAGVPARTPPGHGLSEIQQLFGCIALAGANVFGLAREYGHYAGYVKTFRRIQ

GA

SEHTHGRLCEAVGLSGGVLSQTLARIMGPAVPTEHLASLRRTLVGEFETAERRFSAGQPSLLRETALI WL

DVYGQTHWDLTPTTPATPLSALLPVGPPSHAPSVHLAAATKIRFPALEGIHPNVLADPGFVPYVLALV

VG

DALRATCNAAYLPRPIEFALRVLAWARDFGLGYLPTVEGHRTKLGALITLLEPATRAGVGPTMQMADN

IE QLLRELYVIARGAVEQLRPAVQLPPPQPPEVGSSLLLISMYALAARGVLQELAERADPLVRQLEDAIV

LL

RLHMRTLAAFFECRFESDGHRLYAWADAHERLGPWRPEAMGDAVSQYCGMYHDAKRALVASLAGLRS

W

TETTAHLGVCDELAAQVSHEGNVLAWRREIHGFLAIVSGIHARASKLMSGDQVPGFCYMSQFLARWR RL SAGYQAARAATGPERVAEFVQELHDTWKGLQTERALWAPFASSADQRTAAIQEVMAHATEDAPPSPA AD

LVVLTNRHDLGAWGDYSLGPLGQPTVVPDSVDLSPQGLAATLSMDWLLINELLQVTDGVFRASAFRPS AG PEAPGDLEAQDAGGSTPEPTTPGPQDTQARAPSTRPAGRETVPWPNTPVEDDEMTPQETPPVHP*

Gene matched : gi | 136894 | sp | P10221 | V120_HSV11 Gene name : CAPSID ASSEMBLY PROTEIN UL37

[SEQ ID NO:254] ORF # = 42 from Contig 15 ORF start site = 78158 ORF end site = 81592 ORF sequence:

MANRPAASALAGARSPSERQEPREPEVAPPGGDHVFCRKVSGVMVLSSDPPGPAAYRISDSSFVQCGS NC SMIIDGDVARGHLRDLEGATSTGAFVAISNVAAGGDGRTAWALGGTSGPSATTSVGTQTSGEFLHGN PR

TPEPQGPQAVPPPPPPPFPWGHECCARRDARGGAEKDVGAAESWΞDGPSSDSETEDSDSSDEDTGSGS ET

LSRSSSIWAAGATDDDDSDSDSRSDDSVQPDVWRRRWSDGPAPVAFPKPRRPGDSPGNPGLGAGTGP GS ATDPRASADSDSAAHAAAPQADVAPVLDSQPTVGTDPGYPVPLELTPENAEAVARFLGDAVDREPALM LE

YFCRCAREESKRVPPRTFGSAPRLTEDDFGLLNYALAEMRRLCLDLPPVPPNAYTPYHLREYATRLVN GF KPLVRRSARLYRILGILVHLRIRTREASFEEWMRSKEVDLDFGLTERLREHEAQLMILAQALNPYDCL iH

STPNTLVERGLQSALKYEEFYLKRFGGHYMESVFQMYTRIAGFLACRATRGMRHIALGRQGSWWEMFK FF

FHRLYDHQIVPSTPAMLNLGTRNYYTSSCYLVNPQATTNQATLRAITGNVSAILARNGGIGLCMQAFN DA SPGTASIMPALKVLDSLVAAHNKQSTRPTGACVYLEPWHSDVRAVLRMKGVLAGEEAQRCDNIFSALW MP

DLFFKRLIRHLDGEKNVTWSLFDRDTSMSLADFHGEEFEKLYEHLEAMGFGETIPIQDLAYAIVRSAA TT

GSPFIMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPSSKRSSGVCNLGSVNLARCVSRRTFDFGMLRD AV

QACVLMVNIMIDSTLQPTPQCARGHDNLRSMGIGMQGLHTACLKMGLDLESAEFRDLNTHIAEVMLLA

AM

KTSNALCVRGARPFSHFKRSMYRAGRFHWERFSNASPRYEGEWEMLRQSMMKHGLRNSQFIALMPTAA

SA QISDVSEGFAPLFTNLFSKVTRDGETLRPNTLLLKELERTFGGKRLLDAMDGLEAKQWSVAQALPCLD PA

HPLRRFKTAFDYDQELLIDLCADRAPYVDHSQSMTLYVTEKADGTLPASTLVRLLVHAYKRGLKTGMY YC KVRKATNSGVFAGDDNIVCTSCAL*

Gene matched: gi | 1710385 | sp | P09853 |RIR1_HSV23 Gene name: RIBONUCLEOSIDE-DIPHOSPHATE

[SEQ ID NO:255]

ORF # = 43 from Contig 15

ORF start site = 81665

ORF end site = 82658 ORF sequence:

MDPAVSPASTDPLDTHASGAGAAPIPVCPTPERYFYTSQCPDINHLRSLSILNRWLETELVFVGDEED

VS

KLSEGELGFYRFLFAFLSAADDLVTENLGGLSGLFEQKDILHYYVEQECIEWHSRVYNIIQLVLFHN

ND QARRAYVARTINHPAIRVKVDWLEARVRECDSIPEKFILMILIEGVFFAASFAAIAYLRTNNLLRVTC

QS

NDLISRDEAVΉTTASCYIYNNYLGGHAKPEAARVYRLFREAVDIEIGFIRSQAPTDSΞILSPGALAAI

EN

YVRFSADRLLGLIHMQPLYSAPAPDASFPLSLMSTDKHTNFFECRSTSYAGAWNDL*

Gene matched: gi | 132624 | sp| P03174 | RIR2_HSV23 Gene name: RIBONUCLEOSIDE-DIPHOSPHATE R

[SEQ ID NO:256]

ORF # = 44 from Contig 15

ORF start site = 84014

ORF end site = 82941 ORF sequence :

MRRRGHAFAPGDRGTRAAGPGPAAPWGAPSKPALRLAHLFCIRVLRALGYAYINSGQLEADDACANLY

HT

NTVAYVHTTDTDLLLMGCDIVLDISTGYIPTIHCRDLLQYFKMSYPQFLALFVRCHTDLHPNNTYASV

ED VLRECHWTAPSRSQARRAARRERANSRSLESMPTLTAAPVGLETRISWTEILAQQIAGEDDYEEDPPL

QP

PDVAGGPRDGARSSSSEILTPPELVQVPNAQRVAEHRGYVAGRRRHVIHDAPEALDWLPDPMTIAELV

EH

RYVKYVI SLI S PKERGPWTLLKRLPI YQDLRDEDLARS I VTRHITAPDI ADRFLAQLWAHAPPPAFYK DV LAKFWDE*

Gene matched: gi | 549322 | sp | P36699 |VHS_HSV2G Gene name: VIRION HOST SHUTOFF PROTEIN

[SEQ ID NO: 257]

ORF # = 45 from Contig 15 ORF start site = 84914

ORF end site = 86326

ORF sequence:

MAHLPGGAAAAPLSEDAIPSPRERTEDWPPCQIVLQGAELNGILQAFAPLRTSLLDSLLWGDRGILV

HN AIFGEQVFLPLDHSQFSRYRWGGPTAAFLSLVDQKRSLLSVFRANQYPDLRRVELTVTGQAPFRTLVQ

RI

WTTASDGEAVELASETLMKRELTSFAVLLPQGDPDVQLRLTKPQLTKWNAVGDETAKPTTFELGPNG

KF

SVFNARTCVTFAAREEGASSSTSAQVQILTSALKKAGQAAANAKTVYGENTHRTFSVWDDCSMRAVL RR

LQVGGGTLKFFLTADVPSVCVTATGPNAVSAVFLLKPQRVCLNWLGRTPGSSTGSLASQDSRAGPTDS

QD

FSSEPDAGDRGAPEEEGLEGQARVPPAFPEPPGTKRRHAGAEWPADDATKRPKTGVPAAPTRAESPP

LS ARYGPEAAEGGGDGGRYACYFRDLQTGDASPSPLSAFRGPQRPPYGFGLP*

Gene matched: gi | 136905 | sp | P10226 |VPAP_HSV11 Gene name: DNA POLYMERASE PROCESSIVITY

[SEQ ID NO:258] = 15

ORF # = 48 from Contig 15

ORF start site = 89794 ORF end site = 90312

ORF sequence:

MAFRASGPAYQPLAPAASPARARVPAVAWIGVGAIVGAFALVAALVLVPPRSSWGLSPCDSGWQEFNA

GC

VAWDPTPVEHEQAVGGCSAPATLIPRAAAKHLAALTRVQAERSSGYWWVNGDGIRTCLRLVDSVSGID EF

CEELAIRICYYPRSPGGFVRFVTSIRNALGLP*

Gene matched: gi | 136917 | sp| P06483 |UL45_HSV23 Gene name: PROTEIN UL45 HOMOLOG (18 KD [SEQ ID N0:259] ORF # = 49 from Contig 15 ORF start site = 92744 ORF end site = 90579 ORF sequence:

MQRRARGASSLRLARCLTPANLIRGANAGVPERRIFAGCLLPTPEGLLSAAVGVLRQRADDLQPAFLT GA DRSVRLAARHHNTVPESLIVDGLASDPHYDYIRHYASAAKQALGEVELSGGQLSRAILAQYWKYLQTV vp

SGLDIPDDPAGDCDPSLHVLLRPTLLPKLLVRAPFKSGAAAAKYAAAVAGLRDAAHRLQQYMFFMRPA

DP

SRPSTDTALRLSEFLAYVSVLYHWASWMLWTADKYVCRRLGPADRRFVALSGSLEAPAETFARHLDRG

PS GTTGSMQCMALRAAVΞDVLGHLTRLAHLWETGKRSGGTYGIVDAIVSTVEVLSIVHHHAQYIINATLT

GY

WWASDSLNNEYLRAAVDSQERFCRTAAPLFPTMTAPSWARMELSIKSWFGAALAPDLLRSGTPSPHY

ES

ILRLAASGPPGGRGAVGGSCRDKIQRTRRDNAPPPLPRARPHSTPAAPRRFRRHREDLPEPPHVDAAD RG

PEPCAGRPATYYTHMAGAPPRLPPRNPAPPEQRPAAAARPLAAQREAAGVYDAVRTWGPDAEAEPDQM

EN

TYLLPDDDAAMPAGVGLGATPAADTTAAAWPAESHAPRAPSEDADSIYESVSEDGGRVYEEIPWVRVY

EN ICLRRQDAGGAAPPGDAPDSPYIEAENPLYDWGGSALFSPPGATRAPDPGLSLSPMPARPRTNALAND

GP

TNVAALSALLTKLKRGRHQSH*

Gene matched: gi | 114350 | sp | P10230 |ATI2_HSV11 Gene name: LPHA TRANS-INDUCING FACTOR

[SEQ ID NO:260] ORF # = 50 from Contig 15

ORF start site = 93910

ORF end site = 92828

ORF sequence:

VGAAAVPLLSAGGAAPPHPGPDAAVFRSSLGSLLYWPGVRALLGRDCRVAARYAGRMTYIATGALLAR FN

PGAVKCVLPREAAFAGRVLDVLAVLAEQTVQWLSVWGARLHPHSAHPAFVDVEQEALFRALPLGSPG

W

AAEHEALGDTAARRLLATSGLNAVLGAAVYALHTALATVTLKYALACGDARRRRDHAAAARAVLATGL

IL QRLLGIADTWACVALAAFDGGSTAPEVGTYTPLRYACVLRATQPLYARTTPAKFWADVRAAAEHVDL RP

ASSAPRAPVSGTADPAFLLEDLAAFPPAPLNSESVLGPRVRWDIMAQFRKLLMGDEETAALRAHVSG RR ATGLGGPPRP*

Gene matched : gi | 136920 | sp | P10231 | UL47_HSV11 Gene name : VIRION PROTEIN UL47

[SEQ ID NO:261]

ORF # = 51 from Contig 15

ORF start site = 94919 ORF end site = 93504

ORF sequence:

MSVRGHAVRRRRASTRSHAPSAHRADSPVEDEPEGGGVGLMGYLRAVFNVDDDSEVEAAGEMASEEPP

PR

RRREARGHPGSRRASEARAAAPPRRASFPRPRSVTARSQSVRGRRDSAITRAPRGGYLGPMDPRDVLG RV

GGSRWPSPLFLDELSYEEDDYPAAVAHDDGAGARPPATVEILAGRVSGPELQAAFPLDRLTPRVAAW

DE

SVRSALALGHPAGFYPCPDSAFGLSRVGVMHFASPADPKVFFRQTLQQGEALAWYVTGDAILDLTDRR

AK TSPSRAMGFLVDAIVRVAINGWVCGTRLHTEGARLGARRQGGRAPTAVREPHGVAARGGRRRAAAQRG

RG

RAPPPRPRRRGLSQFAGVPAVLARGARAPGARLSRGRPLRGAHDVHRHRGSARPLQPRRRQMRAPAGG

RV

CGARPGRAGGPGGADGPVALGGRGGAPAPALRPPRVCGRGAGGAVSRPAPG*

Gene matched: gi | 136920 | sp | P10231 | UL47_HSV11 Gene name: VIRION PROTEIN UL47

[SEQ ID NO: 262] ORF # = 53 from Contig 15 ORF start site = 98257 ORF end site = 97349 ORF sequence:

MTSRRSVKSCPREAPRGTHEELYYGPVSPADPESPRDDFRRGAGPMRARPRGEVRFLHYDEAGYALYR DS

SSSEDNDESRDTARPRRSASVAGSHGPGPARAPPPPGGPVGAGGRSHAPPARTPKMTRGAPKAPATPA TD PARGRRPAQADSAVLLDAPAPTASGRTKTPAQGLAKKLHFSTAPPSPTAPWTPRVAGFNKRVFCAAVG RL

AATHARLAAVQLWDMSRPHTDEDLNELLDLTTIRVTVCEGKNLLQRANELVNPDAAQDVDATAAARGR PA GRAAATARAPARSASRPRRPLE*

Gene matched: gi | 136927 | sp | P10233 |UL49_HSVll Gene name: TEGUMENT PROTEIN UL49

[SEQ ID NO: 263] ORF # = 54 fro Contig 15 ORF start site = 98876 ORF end site = 98596 ORF sequence:

WLLFVALVAGVPGEPPNAAGARGVIGDAQCRGDSAGWSVPGVLVPFYLGMTSMGVCMIAHVYQICQ RA LAAGSA*

Gene matched: gi | 1944541 | gnl | PID| e312365 Gene name: (X14112) envelope protein [human

[SEQ ID NO: 264]

ORF # = 55 from Contig 15

ORF start site = 98867

ORF end site = 99976 ORF sequence :

MSQWGPRAILVQTDSTNRNADGDWQAAVAIRGGGWQLNMVNKRAVDFTPAECGDSEWAVGRVSLGLR

MA

MPRDFCAIIHAPAVSGPGPHVMLGLVDSGYRGTVLAVWAPNGTRGFAPGALRVDVTFLDIRATPPTL

TE PSSLHRFPQLAPSPLAGLREDPWLDGALATAGGAVALPARRRGGSLVYAGELTQVTTEHGDCVHEAPA

FL

PKREEDAGFDILIHRAVTVPANGATVIQPSLRVLRAADGPEACYVLGRSSLNARGLLVMPTRWPSGHA

CA

FWCNLTGVPVTLQAGSKVAQLLVAGTHALPWIPPDNIHEDGAFRAYPRGVPDATATPRDPPILVFTN EF

DADAPPSKRGAGGFGSTGI*

Gene matched: gi | 118955 | sp | P10234 |DUT_HSV11 Gene name: DEOXYURIDINE 5 ' -TRIPHOSPHATE [ SEQ ID NO : 265 ] ORF # = 56 from Contig 15 ORF start site = 101006 ORF end site = 100182 ORF sequence :

MASLLGVLCGWGTRPEEQQYEMIRAAAPPSXXDPRLQEALAWNALLPAPITLDDALESLDDTRRLVK AR ALARTYHACMVNLERLARHHPGLEGSTIDGAVAAHRDKMRRLADTCMATILQMYMSVGAADKSADVLV SQ

AIRSMAESDWMEDVAIAERALGLSTSALAGGTRTAGLGATEAPPGPTRAQAPEVASVPVTHAGDRSP VR PGPVPPADPTPDPRHRTSAPKRQASSTEAPLLLA*

Gene matched: gi | 136933 | sp| P10235 | UL51_HSV1 Gene name: PROTEIN U 51

[SEQ ID NO:266]

ORF # = 58 from Contig 15

ORF start site = 102815

ORF end site = 104188

ORF sequence : MYVNRNEIFNAALAVTNIILDLDIALKEPVPFPRLHEALGHFRRGALAAVQLLFPAARVDPDAYPCYF

FK

SACRPRAPPVCAGDGPSAGGDDGDGDWFPDAGGDDGDEEWEEDTDPMDTTHGPLPDDEAAYLDLLHEQ

IP

AATPSEPDSWCSCADKIGLRVCLPVPAPYWHGSLTMRGVARVIQQAVLLDRDFVEAVGSHVKNFLL ID

TGVYAHGHSLRLPYFAKIGPDGSACGRLLPVFVIPPACEDVPAFVAAHADPRRFHFHAPPMFSAAPRE

IR

VLHSLGGDYVSFFEKKASRNALEHFGRRETLTEVLGRYDVRPDAGETVEGFASELLGRIVACIEAHFP EH AREYQAVSVRRAVIKDDWVLLQLIPGRGALNQSLSCLRFKHGRASRATARTFLALSVGTNNRLCASLC QQ CFATKCDNNRLHTLFTVDAGTPCSRSAPSSTSRPSSS*

Gene matched: gi | 136939 | sp | P10236 | UL52_HSV11 Gene name: DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO:267] ORF # = 59 from Contig 15 ORF start site = 104140 ORF end site = 105156 ORF sequence :

MLAVRSLQHLTTVIFITAYGLVLAWYIVFGASPLHRCIYAVRPAGAHNDTALVWMKINQTLLFLGPPT AP

P∞AWTPHAHVCYANIIEGRAVSLPAIPGAMSRRVMNVHEAWCLEALWDTQMRLVWGWFLYLAFVA LH

QRRCMFGWSPAHSMVAPATYLLNYAGRIVSSVFLQYPYTKITRLLCELSVQRQTLVQLFEADPVTFL YH RPAVGVIVGCELLLRFVALGLIVGTALISRGACAITYPLFLTITTWCFVSIIALTELYFILRRDSAPK NA EPAAPRGRSKGWSGVCGRCCSI ILSGIAVRLCYIAWAGWLMALRYEQEIQRRLFDL *

Gene matched : gi | 116105 | sp | P22485 | CELF_HSV2H Gene name : CELL FUSION PROTEIN PRECURSO

[ SEQ ID NO : 268 ] ORF # = 60 from Contig 15 ORF start site = 105702 ORF end site = 107240 ORF sequence :

MATDIDMLIDLGLDLSDSELEEDALERDEEGRRDDPESDSSGECSSSDEDMEDPCGDGGAEAIDAAIP KG

PPARPEDAGTPEASTPRPAARRGADDPPPATTGVWSRLGTRRSASPREPHGGKVARIQPPSTKAPHPR

GG

RRGRRRGRGRYGPGGADSTPNPRRRVSRNAHNQGGRHPASARTDGPGATHGEARRGGEQLDVSGGPRP

RG TRQAPPPLMALSLTPPHADGRAPVPERKAPSADTIDPAVRAVLRSISERAAVERISESFGRSALVMQD

PF

GGMPFPAANSPWAPVLATQAGGFDAETRRVSWETLVAHGPSLYRTFAANPRAASTAKAMRDCVLRQEN

LI

EALASADETLAWCKMCIHHNLPLRPQDPIIGTAAAVLENLATRLRPFLQCYLKARGLCGLDDLCSRRR LS

DIKDIASFVLVILARLANRVERGVSEIDYTTVGVGAGETMHFYIPGACMAGLIEILDTHRQECSSRVC

EL

TASHTIAPLYVHGKYFYCNSLF*

Gene matched: gi | 124181 | sp| P28276 | IE63_HSV2H Gene name: TRANSCRIPTIONAL REGULATOR IE

ORF # = 62 ORF start site = 108542 ORF end site = 108189 ORF sequence :

MIGAHPGVGGDLPSGLPTYAEATSDRPPTYAMVMAACPTEPPGGSVGPADQPRVQSSRTWRPPLVNSR EL YRAQRAARCASSSDTPQAPGWCGGTCRHAVFGWAWWIILAFLWR*

Gene matched: gi | 136952 | sp | P28282 |UL56_HSV2H Gene name: PROTEIN UL56 «gi | 73833 jpir | |w

[SEQ ID NO: 269]

ORF # = 63 from Contig 15

ORF start site = 112958 ORF end site = 113542

ORF sequence:

MHLFCQCPLTDGQDLYLCPVYPRMHQEHLVCPLHRLDDARRRGRTSAAWDEGLVRALTHSGGLMGCGG

RS

LTLSETYWGHPLYEKLVPWDHPRDLKVPEASAVGTRALVPRGRGRPLRGRPVPLIPLDCEPNDGLPFG GG

WPGGRLRGAPVPLHPPPPSAPPLSFTPTLTPPCLCRGLSLCVWKQYLKDRNNF*

Gene matched: gi | 1644457 Gene name: (U72521) neural variant mena+ protein [Mus muscu

TABLE 4

All amino acid sequences within Table 4 are encoded by Contig 15 [SEQ ID NO:217] of Table 3

[SEQ ID NO:270] = 15 ORF # = 9b ORF start site = 14508 ORF end site = 11905 ORF sequence :

MNVATCTHQTHHAARAPGATSAPGAASGDPLGARRPIGDDECEQYTSSVSLARMLYGGDLAEWVPRVH PK TTIERQQHGPVTFPDASAPTARCVTVVRAPMGSGKTTALIRWLGEAIHSPDTSVLWSCRRSFTQTLA

TR

FAESGLPDFVTYFSSTNYIMNDRPFHRLIVQVESLHRVGPNLLNNYDVLVLDEVMSTLGQLYSPTMQQ

LG RVDALMLRLLRTCPRI IAMDATANAQLVDFLCSLRGEKNVHWIGEYAMPGFSARRCLFLPRLGPEVL

QA

ALRPPGPAGGAPPPDAPPDATFFGELEARLAGGDNVCIFSSTVSFAEWARFCRQFTDRVLLLHSLTP

PG

DVTTWGRYRVVIYTTVVTVGLSFDPPHFDSMFAYVKPMNYGPDMVSVYQSLGRVRTLRKGELLIYMDG SG

ARSEPVFTPMLLNHWSASGQWPAQFSQVTNLLCRRFKGRCDASHADAAQARGSRIYSKFRYKHYFER

CT

LACLADSLNILHMLLTLNCMHVRFWGHDAALTPRNFCLFLRGIHFDALRAQRDLRELRCQDPDTSLSA

QA AETEEVGLFVEKYLRPDVAPAEWALMRGLNSLVGRTRFIYLVLLEACLRVPMAAHSSAIFRRLYDHY

AT

GVIPTINAAGELELVALHPTLNVAPVWELFRLCSTMAACLQWDSMAGGSGRTFSPEDVLELLNPHYDR

YM

QLVFELGHCNVTDGPLLSEDAVKRVADALSGCPPRGSVSETEHALSLFKIIWGELFGVQLAKΞTQTFP GA

GRVKNLTKRAIVELLDAHRIDHSACRTHRQLYALLMAHKREFAGARFKLRAPAWGRCLRTHASGAQPN

TD

IILEAALSELPTEAWPMMQGAVNFST *

Gene matched: gi | 1869831 | gnl | PID | e304265 Gene name: (Z86099) UL9 [human herpesvirus

[SEQ ID NO:271] = 15 ORF # = 9a

ORF start site = 14520

ORF end site = 11904

ORF sequence :

MAETMNVATCTHQTHHAARAPGATSAPGAASGDPLGARRPIGDDECEQYTSSVSLARMLYGGDLAEWV PR

VHPKTTIERQQHGPVTFPDASAPTARCVTWRAPMGSGKTTALIRWLGEAIHSPDTSVLWSCRRSFT

QT

LATRFAESGLPDFVTYFSSTNYIMNDRPFHRLIVQVESLHRVGPNLLNNYDVLVLDEVMSTLGQLYSP

TM QQLGRVDALMLRLLRTCPRIIAMDATANAQLVDFLCSLRGEKNVHWIGEYAMPGFSARRCLFLPRLG

PE

VLQAALRPPGPAGGAPPPDAPPDATFFGELEARLAGGDNVCIFSSTVSFAEWARFCRQFTDRVLLLH

SL

TPPGDVTTWGRYRWIYTTWTVGLSFDPPHFDSMFAYVKPMNYGPDMVSVYQSLGRVRTLRKGELLI YM DGSGARSEPVFTPMLLNHWSASGQWPAQFΞQVTNLLCRRFKGRCDASHADAAQARGSRIYSKFRYKH YF

ERCTLACLADSLNILHMLLTLNCMHVRFWGHDAALTPRNFCLFLRGIHFDALRAQRDLRELRCQDPDT SL SAQAAETEEVGLFVEKYLRPDVAPAEWALMRGLNSLVGRTRFIYLVLLEACLRVPMAAHSSAIFRRL YD

HYATGVIPTINAAGELELVALHPTLNVAPVWELFRLCSTMAACLQWDSMAGGSGRTFSPEDVLELLNP HY

DRYMQLVFELGHCNVTDGPLLSEDAVKRVADALSGCPPRGSVSETEHALSLFKIIWGELFGVQLAKST QT

FPGAGRVKNLTKRAIVELLDAHRIDHSACRTHRQLYALLMAHKREFAGARFKLRAPAWGRCLRTHASG

AQ

PNTDIILEAALSELPTEAWPMMQGAVNFSTL*

Gene matched: gi | 136806 | sp | P10193 |0BP_HSV11 Gene name: ORIGIN OF REPLICATION BINDING

[SEQ ID NO:272] = 15

ORF # = 20a

ORF start site = 31782

ORF end site = 27630

ORF sequence: MEPANPPRNPMAAPARDPPGYRYAAAMVPTGSILSTIEVASHRRLFDFFARVRSDENΞLYDVEFDALL

GS

YCNTLSLVRFLELGLSVACVCTKFPELAYMNEGRVQFEVHQPLIARDGPHPVEQPVHNYMTKVIDRRA

LN

AAFSLATEAIALLTGEALDGTGISLHRQLRAIQQLARNVQAVLGAFERGTADQMLHVLLEKAPPLALL LP

MQRYLDNGRLATRVARATLVAELKRSFCDTSFFLGKAGHRREAIEAWLVDLTTATQPSVAVPRLTHAD

TR

GRPVDGVLVTTAAIKQRLLQSFLKVEDTEADVPVTYGEMVLNGANLVTALVMGKAVRSLDDVGRHLLE

MQ EEQLEANRETLDELESAPQTTRVRADLVAIGDRLVFLEALEKRIYAATNVPYPLVGAMDLTFVLPLGL

FN

PAMERFAAHAGDLVPAPGHPEPRAFPPRQLFFWGKDHQVLRLSMENAVGTVCHPSLMNIDAAVGGVNH

DP

VEAANPYGAYVAAPAGPGADMQQRFLNAWRQRLAHGRVRWVAECQMTAEQFMQPDNANLALELHPAFD FF

AGVADVELPGGEVPPAGPGAIQATWRWNGNLPLALCPVAFRDARGLELGVGRHAMAPATIAAVRGAF

ED

RSYPAVFYLLQAAIHGSEHVFCALARLVTQCITSYWNNTRCAAFVNDYSLVSYIVTYLGGDLPEECMA

VY RDLVAHVEALAQLVDDFTLPGPELGGQAQAELNHLMRDPALLPPLVWDCDGLMRHAALDRHRDCRIDA

GG

HEPVYAAACNVATADFNRNDGRLLHNTQARAADAADDRPHRPADWTVHHKIYYYVLVPAFSRGRCCTA

GV RFDRVYATLQNMWPEIAPGEECPSDPVTDPAHPLHPANLVANTVNAMFHNGRVWDGPAMLTLQVLA

HN

MAERTTALLCSAAPDAGANTASTANMRIFDGALHAGVLLMAPQHLDHTIQNGEYFYVLPVHALFAGAD

HV

ANAPNFPPALRDLARHVPLVPPALGANYFS S IRQPWQHARESAAGENALTYALMAGYFKMS PVALYH QL

KTGLHPGFGFTWRQDRFVTENVLFSERASEAYFLGQLQVARHETGGGVSFTLTQPRGNVDLGVGYTA

VA

ATATVRNPVTDMGNLPQNFYLGRGAPPLLDNAAAVYLRNAWAGNRLGPAQPLPVFGCAQVPRRAGMD

HG QDAVCEFIATPVATDINYFRRPCNPRGRAAGGVYAGDKEGDVIALMYDHGQSDPARPFAATANPWASQ

RF

SYGDLLYNGAYHLNGASPVLSPCFKFFTAADITAKHRCLERLIVETGSAVSTATAASDVQFKRPPGCR

EL

VEDPCGLFQEAYPITCASDPALLRSARDGEAHARETHFTQYLIYDASPLKGLSL*

Gene matched: gi | 137571 | sp| P06491 |VCAP_HSV11 Gene name: MAJOR CAPSID PROTEIN (MCP)

[SEQ ID NO:273] = 15

ORF # = 20b

ORF start site = 31754

ORF end site = 27630

ORF sequence: MAAPARDPPGYRYAAAMVPTGSILSTIEVASHRRLFDFFARVRSDENSLYDVEFDALLGSYCNTLSLV

RF

LELGLSVACVCTKFPELAYMNEGRVQFEVHQPLIARDGPHPVEQPVHNYMTKVIDRRALNAAFSLATE

Al

ALLTGEALDGTGISLHRQLRAIQQLARNVQAVLGAFERGTADQMLHVLLEKAPPLALLLPMQRYLDNG RL

ATRVARATLVAELKRSFCDTSFFLGKAGHRREAIEAWLVDLTTATQPSVAVPRLTHADTRGRPVDGVL

VT

TAAIKQRLLQSFLKVEDTEADVPVTYGEMVLNGANLVTALVMGKAVRSLDDVGRHLLEMQEEQLEANR

ET LDELESAPQTTRVRADLVAIGDRLVFLEALEKRIYAATNVPYPLVGAMDLTFVLPLGLFNPAMERFAA

HA

GDLVPAPGHPEPRAFPPRQLFFWGKDHQVLRLSMENAVGTVCHPSLMNIDAAVGGVNHDPVEAANPYG

AY

VAAPAGPGADMQQRFLNAWRQRLAHGRVRWVAECQMTAEQFMQPDNANLALELHPAFDFFAGVADVEL PG GEVPPAGPGAIQATWRWNGNLPLALCPVAFRDARGLELGVGRHAMAPATIAAVRGAFEDRSYPAVFY

LL

QAAIHGSEHVFCALARLVTQCITSYWNNTRCAAFVNDYSLVSYIVTYLGGDLPEECMAVYRDLVAHVE

AL AQLVDDFTLPGPELGGQAQAELNHLMRDPALLPPLVWDCDGLMRHAALDRHRDCRIDAGGHEPVYAAA

CN

VATADFNRNDGRLLHNTQARAADAADDRPHRPADWTVHHKIYYYVLVPAFSRGRCCTAGVRFDRVYAT

LQ

NMWPEIAPGEECPSDPVTDPAHPLHPANLVANTVNAMFHNGRVWDGPAMLTLQVLAHNMAERTTAL LC

SAAPDAGANTASTANMRIFDGALHAGVLLMAPQHLDHTIQNGEYFYVLPVHALFAGADHVANAPNFPP

AL

RDLARHVPLVPPALGANYFSSIRQPWQHARESAAGENALTYALMAGYFKMSPVALYHQLKTGLHPGF

GF TVVRQDRFVTENVLFSERASEAYFLGQLQVARHETGGGVSFTLTQPRGNVDLGVGYTAVAATATVRNP

VT

DMGNLPQNFYLGRGAPPLLDNAAAVYLRNAWAGNRLGPAQPLPVFGCAQVPRRAGMDHGQDAVCEFI

AT

PVATDINYFRRPCNPRGRAAGGVYAGDKEGDVIALMYDHGQSDPARPFAATANPWASQRFSYGDLLYN GA

YHLNGASPVLSPCFKFFTAADITAKHRCLERLIVETGSAVSTATAASDVQFKRPPGCRELVEDPCGLF

QE

AYPITCASDPALLRSARDGEAHARETHFTQYLIYDASPLKGLSL*

Gene matched: gi | 137571 | sp | P06491 |VCAP_HSV11 Gene name: MAJOR CAPSID PROTEIN (MCP)

[SEQ ID NO:274] = 15 ORF # = 22a

ORF start site = 33002

ORF end site = 34984

ORF sequence :

MRPELSLKGRPCVTEAWCPSTDAAIHSGGSSSVRPQPYARAARARATHGSRSRHRQPLLPPPSSHHP Tl

PPPPSPPRGSPAMELSYATTLHHRDWFYVTADRNRAYFVCGGSVYSVGRPRDSQPGEIAKFGLWRG

TG

PKDRMVANYVRSELRQRGLRDVRPVGEDEVFLDSVCLLNPNVSSERDVINTNDVEVLDECLAEYCTSL

RT SPGVLVTGVRVRARDRVIELFEHPAIVNISSRFAYTPSPYVFALAQAHLPRLPSSLEPLVSGLFDGIP

AP

RQPLDARDRRTDWITGTRAPRPMAGTGAGGAGAKRATVSEFVQVKHIDRWSPSVSSAPPPSAPDAS

LP

PPGLQEAAPPGPPLRELWWVFYAGDRALEEPHAESGLTREEVRAVHGFREQAWKLFGSVGAPRAFLGA AL ALSPTQKLAVYYYLIHRERRMSPFPALVRLVGRYIQRHGLYVPAPDEPTLADAMNGLFRDALAAGTVA EQ

LLMFDLLPPKDVPVGSDARADSAALLRFVDSQRLTPGGSVSPEHVMYLGAFLGVLYAGHGRLAAATHT AR LTGVTSLVLTVGDVDRMSAFDRGPAGAAGRTRTAGYLDALLTVCLARAQHGQSV*

Gene matched: gi | 136845 | sp| P10205 |UL21_HSV11 Gene name: PROTEIN UL21

[SEQ ID NO:275] = 15

ORF # = 22b

ORF start site = 33385

ORF end site = 34984 ORF sequence:

MELSYATTLHHRDVVFYVTADRNRAYFVCGGSVYSVGRPRDSQPGEIAKFGLVVRGTGPKDRMVANYV

RS

ELRQRGLRDVRPVGEDEVFLDSVCLLNPNVSSERDVINTNDVEVLDECLAEYCTΞLRTSPGVLVTGVR

VR ARDRVIELFEHPAIVNISSRFAYTPSPYVFALAQAHLPRLPSSLEPLVSGLFDGIPAPRQPLDARDRR

TD

WITGTRAPRPMAGTGAGGAGAKRATVSEFVQVKHIDRWSPSVSSAPPPSAPDASLPPPGLQEAAPP

GP

PLRELWWVFYAGDRALEEPHAESGLTREEVRAVHGFREQAWKLFGSVGAPRAFLGAALALSPTQKLAV YY

YLIHRERRMSPFPALVRLVGRYIQRHGLYVPAPDEPTLADAMNGLFRDALAAGTVAEQLLMFDLLPPK

DV

PVGSDARADSAALLRFVDSQRLTPGGSVSPEHVMYLGAFLGVLYAGHGRLAAATHTARLTGVTSLVLT VG DVDRMSAFDRGPAGAAGRTRTAGYLDALLTVCLARAQHGQSV*

Gene matched: gi | 136845 | sp| P10205 |UL21_HSV11 Gene name: PROTEIN UL21

[SEQ ID NO:276] = 15 ORF # = 41a ORF start site = 75756 ORF end site = 77588 ORF sequence :

MTAAALYGGAKYRPGTLRNPGRVASTPRRRGVLYGALCPGIPFVGSGPGAVGWECVCVGGGRRDGGPD QV

YRGRSVGRPNRPFKHLRMHRPSQSDTGTHQRRKPPSPVRVRVFSGGVFFLSALLPPHLHHPPPTTRPL Al GGKTMKTKPLPTAPMAWAESAVETTTSPRELAGHAPLRRVLRPPIARRDGPVLLGDRAPRRTASTMWL LG

IDPAESSPGTRATRDDTEQAVDKILRGARRAGGLTVPGAPRYHLTRQVTLTDLCQPNAERAGALLLAL RH PTDLPHLARHRAPPGRQTERLAEAWGQLLEASALGSGRAESGCARAGLVSFNFLVAACAAAYDARDAA EA

VRAHITTNYGGTRAGARLDRFSECLRAMVHTHVFPHEVMRFFGGLVSWVTQDELASVTAVCΞGPQEAT HT

GHPGRPCSAVTIPACAFVDLDAELCLGGPGAAFLYLVFTYRQCRDQELCCVYWKSQLPPRGLEAALE RL

FGRLRITNTIHGAEDMTPPPPNRNVDFPLAVLAASSQSPRCSASQVTNPQFVDRLYRWQPDLRGRPTA

RT

CTYAAFAELGVMPDNSPRCLHRTERFGAVGVPWILEGWWRPGGWRACA*

Gene matched: gi | 139176 | sp | P22486 |VP19_HSV2G Gene name: CAPSID ASSEMBLY AND DNA MATU

[SEQ ID NO:277] = 15 ORF # = 41b

ORF start site = 75817

ORF end site = 77588

ORF sequence:

MHRPSQSDTGTHQRRKPPSPVRVRVFSGGVFFLSALLPPHLHHPPPTTRPLAIGGKTMKTKPLPTAPM AW

AESAVETTTSPRELAGHAPLRRVLRPPIARRDGPVLLGDRAPRRTASTMWLLGIDPAESSPGTRATRD

DT

EQAVDKILRGARRAGGLTVPGAPRYHLTRQVTLTDLCQPNAERAGALLLALRHPTDLPHLARHRAPPG

RQ TERLAEAWGQLLEASALGSGRAESGCARAGLVSFNFLVAACAAAYDARDAAEAVRAHITTNYGGTRAG

AR

LDRFSECLRAMVHTHVFPHEVMRFFGGLVSWVTQDELASVTAVCSGPQEATHTGHPGRPCSAVTIPAC

AF

VDLDAELCLGGPGAAFLYLVFTYRQCRDQELCCVYWKSQLPPRGLEAALERLFGRLRITNTIHGAED MT

PPPPNRNVDFPLAVLAASSQSPRCSASQVTNPQFVDRLYRWQPDLRGRPTARTCTYAAFAELGVMPDN

SP

RCLHRTERFGAVGVPWILEGWWRPGGWRACA*

Gene matched: gi | 139176 | sp| P22486 |VP19_HSV2G Gene name: CAPSID ASSEMBLY AND DNA MATU

[SEQ ID NO :278] = 15 ORF # = 41c ORF start site = 76188

ORF end site = 77588

ORF sequence:

MKTKPLPTAPMAWAESAVETTTSPRELAGHAPLRRVLRPPIARRDGPVLLGDRAPRRTASTMWLLGID PA

ESSPGTRATRDDTEQAVDKILRGARRAGGLTVPGAPRYHLTRQVTLTDLCQPNAERAGALLLALRHPT

DL

PHLARHRAPPGRQTERLAEAWGQLLEASALGSGRAESGCARAGLVSFNFLVAACAAAYDARDAAEAVR

AH ITTNYGGTRAGARLDRFSECLRAMVHTHVFPHEVMRFFGGLVSWVTQDELASVTAVCSGPQEATHTGH

PG

RPCSAVTIPACAFVDLDAELCLGGPGAAFLYLVFTYRQCRDQELCCVYWKSQLPPRGLEAALERLFG

RL

RITNTIHGAEDMTPPPPNRNVDFPLAVLAASSQSPRCSASQVTNPQFVDRLYRWQPDLRGRPTARTCT YA

AFAELGVMPDNSPRCLHRTERFGAVGVPWILEGWWRPGGWRACA*

Gene matched: gi | 139176 | sp | P22486 |VP19_HSV2G Gene name: CAPSID ASSEMBLY AND DNA MATU

[SEQ ID NO:279] = 15 ORF # = 46a ORF start site = 86432 ORF end site = 87820 ORF sequence:

MAWCGSGLRLRPFHPPSPSFFVLRALIRAGPGPFAASPRAPSGPGCGMCRGDSPGVAGGSGEHCLGG DD GDDGRPRLACVGAIARGFAHLWLQATTLGFVGSWLSRGPYADAMSGAFVIGSTGLGFLRAPPAFARP PT

RVCAWLRLVGGGAAVALWSLGEAGAPPGVPGPATQCLALGAAYAALLVLADDVHPLFLLAPRPLFVGT LG

WVGGLTIGGSARYWWIDPRAAAALTAAWAGLGTTAAGDSFSKACPRHRRFCWSAVESPPPRYAPE DA ERPTDHGPLLPSTHHQRSPRVCGDGAARPENIWVPWTFAGALALAACAARGSDAAPSGPVLPLWPQV FV

GGHAAAGLTELCQTLAPRDLTDPLLFAYVGFQWNHGLMFWPDIAVYAMLGGAVWISLTQVLGLRRR LH KDPDAGPWAAATLRGLFFSVYALGFAAGVLVRPRMAASRRSG*

Gene matched: gi | 136909 | s | P10227 | UL43_HSV11 Gene name: MEMBRANE PROTEIN UL43

[SEQ ID NO:280] = 15 ORF # = 46b

ORF start site = 86576

ORF end site = 87820

ORF sequence: MCRGDSPGVAGGSGEHCLGGDDGDDGRPRLACVGAIARGFAHLWLQATTLGFVGSWLSRGPYADAMS

GA

FVIGSTGLGFLRAPPAFARPPTRVCAWLRLVGGGAAVALWSLGEAGAPPGVPGPATQCLALGAAYAAL

LV

LADDVHPLFLLAPRPLFVGTLGVVVGGLTIGGSARYWWIDPRAAAALTAAVVAGLGTTAAGDSFSKAC PR

HRRFCWSAVESPPPRYAPEDAERPTDHGPLLPSTHHQRSPRVCGDGAARPENIWVPWTFAGALALA

AC

AARGSDAAPSGPVLPLWPQVFVGGHAAAGLTELCQTLAPRDLTDPLLFAYVGFQWNHGLMFWPDIA

VY AMLGGAVWISLTQVLGLRRRLHKDPDAGPWAAATLRGLFFSVYALGFAAGVLVRPRMAASRRSG*

Gene matched: gi | 136909 | sp| P10227 |UL43_HSV11 Gene name: MEMBRANE PROTEIN UL43

[SEQ ID NO:281] = 15

ORF # = 57a

ORF start site = 100984

ORF end site = 102942 ORF sequence :

MGTEDCDHEGRSVAAPVEVMALYATDGCVITSSLALLTNCLLGAEPLYIFSYDAYRPDAPNGPTGAPT

EQ

ERFEGSRALYRDAGGLNGDSFRVTFCLLGTEVGVTHHPKGRTRPMFVCRFERADDVAVLQDALGRGTP

LL PAHITATLDLEATFALHANIIMALTVAIVHNAPARIGSGSTAPLYEPGESMRSWGRMSLGQRGLTTL

FV

HHEARVLAAYRRAYYGSAQSPFWFLSKFGPDEKSLVLAARYYVLQAPRLGGAGATYDLQAVKDICATY

Al

PHDPRPDTLSAASLTSFAAITRFCCTSQYSRGAAAAGFPLYVERRIAADVRETGALEKFIAHDRSCLR VS

DREFITYIYLAHFECFSPPRLATHLRAVTTHDPSPAASTEQPSPLGREAVEQFFRHVRAQLNIREYVK

QN

VTPRETALAGDAAAAYLRARTYAPAALTPAPAYCGVADSSTKMMGRLAEAERLLVPHGWPAFAPTTPG

DD AGGGTAAPQTCGIVKRLLKLAATEQQGTTPPAIAALMQDASVQTPLPVYRITMSPTGQAFAAAARDDW

AR

VTRDARPPEATWADAAAAPEPGALGRRLTRRICARGPAPPPGRPGRRGPDVREPQRDLQRRAGRYEH

HP

GSGHRPEGARPLSPAPRGPGSL* Gene matched : gi | 136939 | sp | P10236 | UL52_HSV11 Gene name : DNA HELICASE/PRIMASE COMPLEX

[ SEQ ID NO : 282 ] = 15

ORF # = 57b

ORF start site = 100765

ORF end site = 102942

ORF sequence : MGAGKSALTTARASCSRGSXSEGGAAARIISYCCSSGRVPQPHSTPSRDAIPEHARGSAPAFPHPTPS

GF

AGAMGTEDCDHEGRSVAAPVEVMALYATDGCVITSSLALLTNCLLGAEPLYIFSYDAYRPDAPNGPTG

AP

TEQERFEGSRALYRDAGGLNGDSFRVTFCLLGTEVGVTHHPKGRTRPMFVCRFERADDVAVLQDALGR GT

PLLPAHITATLDLEATFALHANIIMALTVAIVHNAPARIGSGSTAPLYEPGESMRSWGRMSLGQRGL

TT

LFVHHEARVLAAYRRAYYGSAQSPFWFLSKFGPDEKSLVLAARYYVLQAPRLGGAGATYDLQAVKDIC

AT YAIPHDPRPDTLSAASLTSFAAITRFCCTSQYSRGAAAAGFPLYVERRIAADVRETGALEKFIAHDRS

CL

RVSDREFITYIYLAHFECFSPPRLATHLRAVTTHDPSPAASTEQPSPLGREAVEQFFRHVRAQLNIRE

YV

KQNVTPRETALAGDAAAAYLRARTYAPAALTPAPAYCGVADSSTKMMGRLAEAERLLVPHGWPAFAPT TP

GDDAGGGTAAPQTCGIVKRLLKLAATEQQGTTPPAIAALMQDASVQTPLPVYRITMSPTGQAFAAAAR

DD

WARVTRDARPPEATWADAAAAPEPGALGRRLTRRICARGPAPPPGRPGRRGPDVREPQRDLQRRAGR

YE HHPGSGHRPEGARPLSPAPRGPGSL*

Gene matched: gi | 136939 | sp| P10236 |UL52_HSV11 Gene name: DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO:283] = 15 ORF # = 57c

ORF start site = 100678 ORF end site = 102942 ORF sequence:

MQAWYVRARARAFTRRRVSSSDSRASSSVMGAGKSALTTARASCSRGSXSEGGAAARIISYCCSSGRV PQ

PHSTPSRDAIPEHARGSAPAFPHPTPSGFAGAMGTEDCDHEGRSVAAPVEVMALYATDGCVITSSLAL LT NCLLGAEPLYIFSYDAYRPDAPNGPTGAPTEQERFEGSRALYRDAGGLNGDSFRVTFCLLGTEVGVTH

HP

KGRTRPMFVCRFERADDVAVLQDALGRGTPLLPAHITATLDLEATFALHANIIMALTVAIVHNAPARI

GS GSTAPLYEPGESMRSWGRMSLGQRGLTTLFVHHEARVLAAYRRAYYGSAQSPFWFLSKFGPDEKSLV

LA

ARYYVLQAPRLGGAGATYDLQAVKDICATYAIPHDPRPDTLSAASLTSFAAITRFCCTSQYSRGAAAA

GF

PLYVERRIAADVRETGALEKFIAHDRSCLRVSDREFITYIYLAHFECFSPPRLATHLRAVTTHDPSPA AS

TTEQPSPLGREAVEQFFRHRAQLNIREYVKQNVTPRETALAGDAAAAYLRARTYAPAALTPAPAYCGV

AD

SSTKMMGRLAEAERLLVPHGWPAFAPTTPGDDAGGGTAAPQTCGIVKRLLKLAATEQQGTTPPAIAAL

MQ DASVQTPLPVYRITMSPTGQAFAAAARDDWARVTRDARPPEATWADAAAAPEPGALGRRLTRRICAR

GP

APPPGRPGRRGPDVREPQRDLQRRAGRYEHHPGSGHRPEGARPLSPAPRGPGSL*

Gene matched: gi | 136939 | sp | P10236 |UL52_HSV11 Gene name: DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO:284] = 15

ORF # = 57d ORF start site = 100624

ORF end site = 102942

ORF sequence:

MVEPSSPGWWRASLSRLTMQAWYVRARARAFTRRRVSSSDSRASSSVMGAGKSALTTARASCSRGSXS

EG GAAARIISYCCSSGRVPQPHSTPSRDAIPEHARGSAPAFPHPTPSGFAGAMGTEDCDHEGRSVAAPVE

VM

ALYATDGCVITSSLALLTNCLLGAEPLYIFSYDAYRPDAPNGPTGAPTEQERFEGSRALYRDAGGLNG

DS

FRVTFCLLGTEVGVTHHPKGRTRPMFVCRFERADDVAVLQDALGRGTPLLPAHITATLDLEATFALHA NI

IMALTVAIVHNAPARIGSGSTAPLYEPGESMRSWGRMSLGQRGLTTLFVHHEARVLAAYRRAYYGSA

QS

PFWFLSKFGPDEKSLVLAARYYVLQAPRLGGAGATYDLQAVKDICATYAIPHDPRPDTLSAASLTSFA

Al TRFCCTSQYSRGAAAAGFPLYVERRIAADVRETGALEKFIAHDRSCLRVSDREFITYIYLAHFECFSP

PR

LATHLRAVTTHDPΞPAASTEQPSPLGREAVEQFFRHVRAQLNIREYVKQNVTPRETALAGDAAAAYLR

AR

TYAPAALTPAPAYCGVADSSTKMMGRLAEAERLLVPHGWPAFAPTTPGDDAGGGTAAPQTCGIVKRLL KL AATEQQGTTPPAIAALMQDASVQTPLPVYRITMSPTGQAFAAAARDDWARVTRDARPPEATWADAAA AP

EPGALGRRLTRRICARGPAPPPGRPGRRGPDVREPQRDLQRRAGRYEHHPGSGHRPEGARPLSPAPRG PG SL*

Gene matched: gi | 136939 | sp | P10236 |UL52_HSV11 Gene name: DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO:285] = 15

ORF # = 57e

ORF start site = 100567

RF end site = 102942 ORF sequence:

MHVSARRRILSRCAATAPSMVEPSSPGWWRASLΞRLTMQAWYVRARARAFTRRRVSSSDSRASSSVMG

AG

KSALTTARASCSRGSXSEGGAAARIISYCCSSGRVPQPHSTPSRDAIPEHARGSAPAFPHPTPSGFAG

AM GTEDCDHEGRSVAAPVEVMALYATDGCVITSSLALLTNCLLGAEPLYIFSYDAYRPDAPNGPTGAPTE

QE

RFEGSRALYRDAGGLNGDSFRVTFCLLGTEVGVTHHPKGRTRPMFVCRFERADDVAVLQDALGRGTPL

LP

AHITATLDLEATFALHANIIMALTVAIVHNAPARIGSGSTAPLYEPGESMRSWGRMΞLGQRGLTTLF VH

HEARVLAAYRRAYYGSAQSPFWFLSKFGPDEKSLVLAARYYVLQAPRLGGAGATYDLQAVKDICATYA

IP

HDPRPDTLSAASLTSFAAITRFCCTSQYSRGAAAAGFPLYVERRIAADVRETGALEKFIAHDRSCLRV

SD REFITYIYLAHFECFSPPRLATHLRAVTTHDPSPAASTEQPSPLGREAVEQFFRHVRAQLNIREYVKQ

NV

TPRETALAGDAAAAYLRARTYAPAALTPAPAYCGVADSSTKMMGRLAEAERLLVPHGWPAFAPTTPGD

DA

GGGTAAPQTCGIVKRLLKLAATEQQGTTPPAIAALMQDASVQTPLPVYRITMSPTGQAFAAAARDDWA RV

TRDARPPEATWADAAAAPEPGALGRRLTRRICARGPAPPPGRPGRRGPDVREPQRDLQRRAGRYEHH

PG

SGHRPEGARPLSPAPRGPGSL*

Gene matched: gi | 136939 | sp | P10236 |UL52_HSV11 Gene name: DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO:286] 15 ORF # = 57f ORF start site = 100558 ORF end site = 102942 ORF sequence :

MVAMHVSARRRILSRCAATAPSMVEPSSPGWWRASLSRLTMQAWYVRARARAFTRRRVSSSDSRASSS VM

GAGKSALTTARASCSRGSXSEGGAAARIISYCCSSGRVPQPHSTPSRDAIPEHARGSAPAFPHPTPSG FA

GAMGTEDCDHEGRSVAAPVEVMALYATDGCVITSΞLALLTNCLLGAEPLYIFSYDAYRPDAPNGPTGA PT EQERFEGSRALYRDAGGLNGDSFRVTFCLLGTEVGVTHHPKGRTRPMFVCRFERADDVAVLQDALGRG TP

LLPAHITATLDLEATFALHANIIMALTVAIVHNAPARIGSGSTAPLYEPGESMRSWGRMSLGQRGLT TL

FVHHEARVLAAYRRAYYGSAQSPFWFLSKFGPDEKSLVLAARYYVLQAPRLGGAGATYDLQAVKDICA TY

AIPHDPRPDTLSAASLTSFAAITRFCCTSQYSRGAAAAGFPLYVERRIAADVRETGALEKFIAHDRSC

LR

VSDREFITYIYLAHFECFSPPRLATHLRAVTTHDPSPAASTEQPSPLGREAVEQFFRHVRAQLNIREY

VK QNVTPRETALAGDAAAAYLRARTYAPAALTPAPAYCGVADSSTKMMGRLAEAERLLVPHGWPAFAPTT

PG

DDAGGGTAAPQTCGIVKRLLKLAATEQQGTTPPAIAALMQDASVQTPLPVYRITMSPTGQAFAAAARD

DW

ARVTRDARPPEATWADAAAAPEPGALGRRLTRRICARGPAPPPGRPGRRGPDVREPQRDLQRRAGRY EH

HPGSGHRPEGARPLSPAPRGPGSL*

Gene matched: gi | 136939 | sp | P10236 |UL52_HSV11 Gene name: DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO:287] = 15 ORF # = 57g

ORF start site = 100543 ORF end site = 102942 ORF sequence :

MYICRMVAMHVSARRRILSRCAATAPSMVEPSSPGWWRASLSRLTMQAWYVRARARAFTRRRVSSSDS RA SSSVMGAGKSALTTARASCSRGSXSEGGAAARIISYCCSSGRVPQPHSTPSRDAIPEHARGSAPAFPH PT

PSGFAGAMGTEDCDHEGRSVAAPVEVMALYATDGCVITSSLALLTNCLLGAEPLYIFSYDAYRPDAPN GP

TGAPTEQERFEGSRALYRDAGGLNGDSFRVTFCLLGTEVGVTHHPKGRTRPMFVCRFERADDVAVLQD AL GRGTPLLPAHITATLDLEATFALHANIIMALTVAIVHNAPARIGSGSTAPLYEPGESMRSWGRMSLG

QR

GLTTLFVHHEARVLAAYRRAYYGSAQSPFWFLSKFGPDEKSLVLAARYYVLQAPRLGGAGATYDLQAV

KD ICATYAIPHDPRPDTLSAASLTSFAAITRFCCTSQYSRGAAAAGFPLYVERRIAADVRETGALEKFIA

HD

RSCLRVSDREFITYIYLAHFECFSPPRLATHLRAVTTHDPSPAASTEQPSPLGREAVEQFFRHVRAQL

NI

REYVKQNVTPRETALAGDAAAAYLRARTYAPAALTPAPAYCGVADSSTKMMGRLAEAERLLVPHGWPA FA

PTTPGDDAGGGTAAPQTCGIVKRLLKLAATEQQGTTPPAIAALMQDASVQTPLPVYRITMSPTGQAFA

AA

ARDDWARVTRDARPPEATWADAAAAPEPGALGRRLTRRICARGPAPPPGRPGRRGPDVREPQRDLQR

RA GRYEHHPGSGHRPEGARPLSPAPRGPGSL*

Gene matched: gi | 136939 | sp| P10236 |UL52_HSV11 Gene name: DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO:288] = 15

ORF # = 57h

ORF start site = 100483

ORF end site = 102942 ORF sequence:

MLRMAWETSTSADLSAAPTDMYICRMVAMHVSARRRILSRCAATAPSMVEPSSPGWWRASLSRLTMQA Y

VRARARAFTRRRVSSSDSRASSSVMGAGKSALTTARASCSRGSXSEGGAAARIISYCCSSGRVPQPHS

TP SRDAIPEHARGSAPAFPHPTPSGFAGAMGTEDCDHEGRSVAAPVEVMALYATDGCVITSSLALLTNCL

LG

AEPLYIFSYDAYRPDAPNGPTGAPTEQERFEGSRALYRDAGGLNGDSFRVTFCLLGTEVGVTHHPKGR

TR

PMFVCRFERADDVAVLQDALGRGTPLLPAHITATLDLEATFALHANIIMALTVAIVHNAPARIGSGST AP

LYEPGESMRSWGRMSLGQRGLTTLFVHHEARVLAAYRRAYYGSAQSPFWFLSKFGPDEKSLVLAARY

YV

LQAPRLGGAGATYDLQAVKDICATYAIPHDPRPDTLSAASLTSFAAITRFCCTSQYSRGAAAAGFPLY

VE RRIAADVRETGALEKFIAHDRSCLRVSDREFITYIYLAHFECFSPPRLATHLRAVTTHDPSPAASTEQ

PS

PLGREAVEQFFRHVRAQLNIREYVKQNVTPRETALAGDAAAAYLRARTYAPAALTPAPAYCGVADSST

KM

MGRLAEAERLLVPHGWPAFAPTTPGDDAGGGTAAPQTCGIVKRLLKLAATEQQGTTPPAIAALMQDAS VQ TPLPVYRITMSPTGQAFAAAARDDWARVTRDARPPEATWADAAAAPEPGALGRRLTRRICARGPAPP

PG

RPGRRGPDVREPQRDLQRRAGRYEHHPGSGHRPEGARPLSPAPRGPGSL*

Gene matched: gi | 136939 | sp| P10236 |UL52_HSV11 Gene name: DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO:289] = 15 ORF # = 57i

ORF start site = 100242

ORF end site = 102942

ORF sequence :

MTTSLSAMLRMAWETSTSADLΞAAPTDMYICRMVAMHVSARRRILSRCAATAPSMVEPSSPGWWRASL SR

LTMQAWYVRARARAFTRRRVSSSDSRASSSVMGAGKSALTTARASCSRGSXSEGGAAARIISYCCSSG

RV

PQPHSTPSRDAIPEHARGSAPAFPHPTPSGFAGAMGTEDCDHEGRSVAAPVEVMALYATDGCVITSSL

AL LTNCLLGAEPLYIFSYDAYRPDAPNGPTGAPTEQERFEGSRALYRDAGGLNGDSFRVTFCLLGTEVGV

TH

HPKGRTRPMFVCRFERADDVAVLQDALGRGTPLLPAHITATLDLEATFALHANIIMALTVAIVHNAPA

RI

GSGSTAPLYEPGESMRSWGRMSLGQRGLTTLFVHHEARVLAAYRRAYYGSAQSPFWFLSKFGPDEKS LV

LAARYYVLQAPRLGGAGATYDLQAVKDICATYAIPHDPRPDTLSAASLTSFAAITRFCCTSQYSRGAA

AA

GFPLYVERRIAADVRETGALEKFIAHDRSCLRVSDREFITYIYLAHFECFSPPRLATHLRAVTTHDPS

PA ASTEQPSPLGREAVEQFFRHVRAQLNIREYVKQNVTPRETALAGDAAAAYLRARTYAPAALTPAPAYC

GV

AADSSTKMMGRLAEAERLLVPGWPAFAPTTPGDDAGGGTAAPQTCGIVKRLLKLAATEQQGTTPPAIA

AL

MQDASVQTPLPVYRITMSPTGQAFAAAARDDWARVTRDARPPEATWADAAAAPEPGALGRRLTRRIC AR

GPAPPPGRPGRRGPDVREPQRDLQRRAGRYEHHPGSGHRPEGARPLSPAPRGPGΞL*

Gene matched: gi | 136939 | sp | P10236 | UL52_HSV11 Gene name: DNA HELICASE/PRIMASE COMPLEX

[SEQ ID NO:290] = 15 ORF # = 61a

ORF start site = 107456 ORF end site = 108016 ORF sequence :

MTTTPLSNLFLRAPDITHVAPPYCLNATWQAENALHTTKTDPACLAARSYLVRASCSTSGPIHCFFFA

VY

KDSQHSLPLVTELRNFADLVNHPPVLRELEDKRGGRLRCTGPFSCGTIKDVSGASPAGEYTINGIVYH

CH

CRYPFSKTCWLGASAALQHLRSISSSGTAARAAEQRRHKIKIKIKV*

Gene matched: gi | 136947 | sp| P28281 |UL55_HSV2H Gene name: PROTEIN UL55^ΛAgi | 73806 |pir| |w

[SEQ ID NO:291] = 15

ORF # = 61b

ORF start site = 107372

ORF end site = 108016 ORF sequence:

MWGPGPARFIARPGTHGRRVFTDPPPRNMTTTPLSNLFLRAPDITHVAPPYCLNATWQAENALHTTKT

DP

ACLAARSYLVRASCSTSGPIHCFFFAVYKDSQHSLPLVTELRNFADLVNHPPVLRELEDKRGGRLRCT

GP FSCGTIKDVSGASPAGEYTINGIVYHCHCRYPFSKTCWLGASAALQHLRSISSSGTAARAAEQRRHKI

KI

KIKV*

Gene matched: gi | 136947 | sp | P28281 |UL55_HSV2H Gene name: PROTEIN UL55^ΛAgi | 73806 |pir | |w

[SEQ ID NO:292] = 15

ORF # = 6a ORF start site = 6446

ORF end site = 8482

ORF sequence :

MAAQRARAPAMRTRGGDAALCAPEDGWVKVHPTPGTMLFREILLGQMGYTEGQGVYNWRSSEAATRQ

LQ AAIFHALLNATTYRDLEEDWRRHWARGLQPQRLVRRYRNAREGDIAGVAERVFDTWRCTLRTTLLDF

AH

GWDCFAPGGPΞGPTSFPKYIDWLTCLGLVPILRKTREGEATQRLGAFLRQHTLPRQLATVAGAAERA

GP

GLLELAVAFDSTRMAEYDRVHIYYNHRRGEWLVRDPVSGQRGECLVLCPPLWTGDRLVFDSPVQRLCP Ei

VACHALREHAHICRLRNTASVKVLLGRKSDSERGVAGAAARWNKALGEDDETKAGSAASRLVRLIIM KG

MRHVGDINDTVRAYLDEAGGHLIDTPAVDHTLPGFGKGGTGRGSAAQDPGARPQQLRQAFQTAWNNI NG MLEGYINNLFGTIERLRETNAGLATQLQARDRELRRAQAGALEREQRAADRAAGGGAGRPAEADLLRA DY

DIIDVSKSMDDDTYVANSFQHQYIPAYGQDLERLSRLWEHELVRCFKILRHRNNQGQETSISYSSGAI AS FVAPYFEYVLRAPRAGALITGSDVILGEEELWEAVFKKTRLQTYLTDVAALFVADVQHAALPRPPSPT PA DFRASASPRGGSRSRTRTRSRSPGRTPRGAPDQGWGVERRDGRPHARR*

Gene matched: gi | 136794 | sp | P10190 |UL06_HSV11 Gene name: VIRION PROTEIN UL6^ΛAgi | 73994 |

[SEQ ID NO:293] = 15

ORF # = 6b ORF start site = 6326

ORF end site = 8482

ORF sequence :

MDVKFKNASSLNRTAGLAPGCCGGGPGARTSREPSPPDAAMAAQRARAPAMRTRGGDAALCAPEDGWV

KV HPTPGTMLFREILLGQMGYTEGQGVYNWRSSEAATRQLQAAIFHALLNATTYRDLEEDWRRHWARG

LQ

PQRLVRRYRNAREGDIAGVAERVFDTWRCTLRTTLLDFAHGWDCFAPGGPSGPTSFPKYIDWLTCLG

LV

PILRKTREGEATQRLGAFLRQHTLPRQLATVAGAAERAGPGLLELAVAFDSTRMAEYDRVHIYYNHRR GE

WLVRDPVSGQRGECLVLCPPLWTGDRLVFDSPVQRLCPEIVACHALREHAHICRLRNTASVKVLLGRK

SD

SERGVAGAARWNKALGEDDETKAGSAASRLVRLIINMKGMRHVGDINDTVRAYLDEAGGHLIDTPAV

DH TLPGFGKGGTGRGSAAQDPGARPQQLRQAFQTAWNNINGMLEGYINNLFGTIERLRETNAGLATQLQ

AR

DRELRRAQAGALEREQRAADRAAGGGAGRPAΞADLLRADYDIIDVSKSMDDDTYVANSFQHQYIPAYG

QD

LERLSRLWEHELVRCFKILRHRNNQGQETSISYSSGAIASFVAPYFEYVLRAPRAGALITGSDVILGE EE

LWEAVFKKTRLQTYLTDVAALFVADVQHAALPRPPSPTPADFRASASPRGGSRSRTRTRSRSPGRTPR

GA

PDQGWGVERRDGRPHARR*

Gene matched: gi | 136794 | sp | P10190 |UL06_HSV11 Gene name: VIRION PROTEIN UL6^ΛAgi | 73994 |

[SEQ ID NO:294] = 15 ORF # = 6c ORF start site = 6296 ORF end site = 8482

ORF sequence :

MRAMIGWTPCMDVKFKNASSLNRTAGLAPGCCGGGPGARTSREPSPPDAAMAAQRARAPAMRTRGGDA

AL CAPEDGWVKVHPTPGTMLFREILLGQMGYTEGQGVYNWRSSEAATRQLQAAIFHALLNATTYRDLEE

DW

RRHWARGLQPQRLVRRYRNAREGDIAGVAERVFDTWRCTLRTTLLDFAHGWDCFAPGGPSGPTSFP

KY

IDWLTCLGLVPILRKTREGEATQRLGAFLRQHTLPRQLATVAGAAERAGPGLLELAVAFDSTRMAEYD RV

HIYYNHRRGEWLVRDPVSGQRGECLVLCPPLWTGDRLVFDSPVQRLCPEIVACHALREHAHICRLRNT

AS

VKVLLGRKSDSERGVAGAARWNKALGEDDETKAGSAASRLVRLIINMKGMRHVGDINDTVRAYLDEA

GG HLIDTPAVDHTLPGFGKGGTGRGSAAQDPGARPQQLRQAFQTAWNNINGMLEGYINNLFGTIERLRE

TN

AGLATQLQARDRELRRAQAGALEREQRAADRAAGGGAGRPAEADLLRADYDIIDVSKSMDDDTYVANS

FQ

HQYIPAYGQDLERLSRLWEHELVRCFKILRHRNNQGQETSISYSSGAIASFVAPYFEYVLRAPRAGAL IT

GSDVILGEEELWEAVFKKTRLQTYLTDVAALFVADVQHAALPRPPSPTPADFRASASPRGGSRSRTRT

RS

RSPGRTPRGAPDQGWGVERRDGRPHARR*

Gene matched: gi | 136794 | sp| P10190 |UL06_HSV11 Gene name: VIRION PROTEIN UL6^ΛAgi | 73994 |

[SEQ ID NO: 295] = 15

ORF # = 6d ORF start site = 6167

ORF end site = 8482

ORF sequence :

MRYAANGNSRSGRPVGTSKAATSRNHCRRGTCVTSSCCCESSRMRAMIGWTPCMDVKFKNASΞLNRTA

GL APGCCGGGPGARTSREPSPPDAAMAAQRARAPAMRTRGGDAALCAPEDGWVKVHPTPGTMLFREILLG

QM

GYTEGQGVYNWRSSEAATRQLQAAIFHALLNATTYRDLEEDWRRHWARGLQPQRLVRRYRNAREGD

IA

GVAERVFDTWRCTLRTTLLDFAHGWDCFAPGGPSGPTSFPKYIDWLTCLGLVPILRKTREGEATQRL GA

FLRQHTLPRQLATVAGAAERAGPGLLELAVAFDSTRMAEYDRVHIYYNHRRGEWLVRDPVSGQRGECL

VL

CPPLWTGDRLVFDSPVQRLCPEIVACHALREHAHICRLRNTASVKVLLGRKSDSERGVAGAARWNKA

LG EDDETKAGSAASRLVRLIINMKGMRHVGDINDTVRAYLDEAGGHLIDTPAVDHTLPGFGKGGTGRGSA AQ

DPGARPQQLRQAFQTAWNNINGMLEGYINNLFGTIERLRETNAGLATQLQARDRELRRAQAGALERE QR AADRAAGGGAGRPAEADLLRADYDIIDVSKSMDDDTYVANSFQHQYIPAYGQDLERLSRLWEHELVRC FK

ILRHRNNQGQETSISYSSGAIASFVAPYFEYVLRAPRAGALITGSDVILGEEELWEAVFKKTRLQTYL TD

VAALFVADVQHAALPRPPSPTPADFRASASPRGGSRSRTRTRSRSPGRTPRGAPDQGWGVERRDGRPH AR R*

Gene matched: gi | 136794 | sp| P10190 |UL06_HSV11 Gene name: VIRION PROTEIN UL6^ΛAgi I 73994 I

[SEQ ID NO:296] = 15

ORF # = 6e

ORF start site = 6065

ORF end site = 8482 ORF sequence :

MFCAAIRVAPVTTQSRTSLRVCTHVLFPDPALPVMRYAANGNSRSGRPVGTSKAATSRNHCRRGTCVT

SS

CCCESSRMRAMIGWTPCMDVKFKNASSLNRTAGLAPGCCGGGPGARTSREPSPPDAAMAAQRARAPAM

RT RGGDAALCAPEDGWVKVHPTPGTMLFREILLGQMGYTEGQGVYNVVRSSEAATRQLQAAIFHALLNAT

TY

RDLEEDWRRHWARGLQPQRLVRRYRNAREGDIAGVAERVFDTWRCTLRTTLLDFAHGWDCFAPGGP

SG

PTSFPKYIDWLTCLGLVPILRKTREGEATQRLGAFLRQHTLPRQLATVAGAAERAGPGLLELAVAFDS TR

MAEYDRVHIYYNHRRGEWLVRDPVSGQRGECLVLCPPLWTGDRLVFDSPVQRLCPEIVACHALREHAH

IC

RLRNTASVKVLLGRKSDSERGVAGAARWNKALGEDDETKAGSAASRLVRLIINMKGMRHVGDINDTV RA YLDEAGGHLIDTPAVDHTLPGFGKGGTGRGSAAQDPGARPQQLRQAFQTAWNNINGMLEGYINNLFG Tl

ERLRETNAGLATQLQARDRELRRAQAGALEREQRAADRAAGGGAGRPAEADLLRADYDIIDVSKSMDD DT YVANSFQHQYIPAYGQDLERLSRLWEHELVRCFKILRHRNNQGQETSISYSSGAIASFVAPYFEYVLR AP

RAGALITGSDVILGEEELWEAVFKKTRLQTYLTDVAALFVADVQHAALPRPPSPTPADFRASASPRGG

SR

SRTRTRSRSPGRTPRGAPDQGWGVERRDGRPHARR*

Gene matched: gi | 136794 | sp | P10190 |UL06_HΞV11 Gene name : VIRION PROTEIN UL6 ^ΛAgi I 73994 j

[ SEQ ID NO : 297 ] = 15 ORF # = 6 f

ORF start site = 6026 ORF end site = 8482 ORF sequence :

MGRLRNAPESLTYMFCAAIRVAPVTTQSRTSLRVCTHVLFPDPALPVMRYAANGNSRSGRPVGTSKAA TS

RNHCRRGTCVTSSCCCESSRMRAMIGWTPCMDVKFKNASSLNRTAGLAPGCCGGGPGARTSREPSPPD

AA

MAAQRARAPAMRTRGGDAALCAPEDGWVKVHPTPGTMLFREILLGQMGYTEGQGVYNWRSSEAATRQ

LQ AAIFHALLNATTYRDLEEDWRRHWARGLQPQRLVRRYRNAREGDIAGVAERVFDTWRCTLRTTLLDF

AH

GWDCFAPGGPSGPTSFPKYIDWLTCLGLVPILRKTREGEATQRLGAFLRQHTLPRQLATVAGAAERA

GP

GLLELAVAFDSTRMAEYDRVHIYYNHRRGEWLVRDPVSGQRGECLVLCPPLWTGDRLVFDSPVQRLCP El

VACHALREHAHICRLRNTASVKVLLGRKSDSERGVAGAARWNKALGEDDETKAGSAASRLVRLI INM

KG

MRHVGDINDTVRAYLDEAGGHLIDTPAVDHTLPGFGKGGTGRGΞAAQDPGARPQQLRQAFQTAWNNI

NG MLEGYINNLFGTIERLRETNAGLATQLQARDRELRRAQAGALEREQRAADRAAGGGAGRPAEADLLRA

DY

DIIDVSKSMDDDTYVANSFQHQYIPAYGQDLERLSRLWEHELVRCFKILRHRNNQGQETSISYSSGAI

AS

FVAPYFEYVLRAPRAGALITGSDVILGEEELWEAVFKKTRLQTYLTDVAALFVADVQHAALPRPPSPT PA

DFRASASPRGGSRSRTRTRSRSPGRTPRGAPDQGWGVERRDGRPHARR*

Gene matched: gi | 136794 | sp | P10190 ] UL06_HSV11 Gene name: VIRION PROTEIN UL6^ΛAgi | 73994 |

[SEQ ID NO:298] = 15 ORF # = 6g

ORF start site = 6017 ORF end site = 8482 ORF sequence :

MVLMGRLRNAPESLTYMFCAAIRVAPVTTQSRTSLRVCTHVLFPDPALPVMRYAANGNSRSGRPVGTS KA

ATSRNHCRRGTCVTSSCCCESSRMRAMIGWTPCMDVKFKNASΞLNRTAGLAPGCCGGGPGARTSREPS PP DAAMAAQRARAPAMRTRGGDAALCAPEDGWVKVHPTPGTMLFREILLGQMGYTEGQGVYNVVRSSEAA

TR

QLQAAIFHALLNATTYRDLEEDWRRHWARGLQPQRLVRRYRNAREGDIAGVAERVFDTWRCTLRTTL

LD FAHGWDCFAPGGPSGPTSFPKYIDWLTCLGLVPILRKTREGEATQRLGAFLRQHTLPRQLATVAGAA

ER

AGPGLLELAVAFDSTRMAEYDRVHIYYNHRRGEWLVRDPVSGQRGECLVLCPPLWTGDRLVFDSPVQR

LC

PEIVACHALREHAHICRLRNTASVKVLLGRKSDSERGVAGAARVVNKALGEDDETKAGSAASRLVRLI IN

MKGMRHVGDINDTVRAYLDEAGGHLIDTPAVDHTLPGFGKGGTGRGSAAQDPGARPQQLRQAFQTAW

NN

INGMLEGYINNLFGTIERLRETNAGLATQLQARDRELRRAQAGALEREQRAADRAAGGGAGRPAEADL

LR ADYDIIDVSKSMDDDTYVANSFQHQYIPAYGQDLERLSRLWEHELVRCFKILRHRNNQGQETSISYSS

GA

IASFVAPYFEYVLRAPRAGALITGSDVILGEEELWEAVFKKTRLQTYLTDVAALFVADVQHAALPRPP

SP

TPADFRASASPRGGSRSRTRTRSRSPGRTPRGAPDQGWGVERRDGRPHARR*

Gene matched: gi | 136794 | sp | P10190 | UL06_HSV11 Gene name: VIRION PROTEIN UL6^ΛAgi | 73994 |

[SEQ ID NO:299] = 15

ORF # = 47a

ORF start site = 88122

ORF end site = 89564

ORF sequence: MALGRVGLAVGLWGLLWVGWWLANASPGRTITVGPRGNASNAAPSASPRNASAPRTTPTPPQPRKA

TK

SKASTAKPAPPPKTGPPKTSΞEPVRCNRHDPLARYGSRVQIRCRFPNSTRTESRLQIWRYATATDAEI

GT

APSLEEVMVNVSAPPGGQLVYDSAPNRTDPHVIWAEGAGPGASPRLYSWGPLGRQRLIIEELTLETQ GM

YYWVWGRTDRPSAYGTWVRVRVFRPPSLTIHPHAVLEGQPFKATCTAATYYPGNRAEFVWFEDGRRVF

DP

AQIHTQTQENPDGFSTVSTVTSAAVGGQGPPRTFTCQLTWHRDSVSFSRRNASGTASVLPRPTITMEF

TG DHAVCTAGCVPEGVTFAWFLGDDSSPAEKVAVASQTSCGRPGTATIRSTLPVSYEQTEYICRLAGYPD

GI

PVLEHHGSHQPPPRDPTERQVIRAVEGAGIGVAVLVAWLAGTAWYLTHASSVRYRRLR*

Gene matched: gi | 138220 | sp | P06475 |VGLC_HSV23 Gene name: GLYCOPROTEIN C PRECURSOR^ΛAgi | [ SEQ ID NO : 300 ] = 15

ORF # = 47b ORF start site = 87918

ORF end site = 89564

ORF sequence :

MGAGVPWTGIKARGAGGPITVRVLGWEVAQKATHPCCSCPREAWSGNPPRCAGRAHRSFAGAGALLV

MA LGRVGLAVGLWGLLWVGWWLANASPGRTITVGPRGNASNAAPSASPRNASAPRTTPTPPQPRKATK

SK

ASTAKPAPPPKTGPPKTSSEPVRCNRHDPLARYGSRVQIRCRFPNSTRTESRLQIWRYATATDAEIGT

AP

SLEEVMVNVSAPPGGQLVYDSAPNRTDPHVIWAEGAGPGASPRLYSWGPLGRQRLIIEELTLETQGM YY

WVWGRTDRPSAYGTWVRVRVFRPPSLTIHPHAVLEGQPFKATCTAATYYPGNRAEFVWFEDGRRVFDP

AQ

IHTQTQENPDGFSTVSTVTSAAVGGQGPPRTFTCQLTWHRDSVSFSRRNASGTASVLPRPTITMEFTG

DH AVCTAGCVPEGVTFAWFLGDDSSPAEKVAVASQTSCGRPGTATIRSTLPVSYEQTEYICRLAGYPDGI

PV

LEHHGSHQPPPRDPTERQVIRAVEGAGIGVAVLVAWLAGTAWYLTHASSVRYRRLR*

Gene matched: gi | 138220 | sp| P06475 |VGLC_HSV23 Gene name : GLYCOPROTEIN C PRECURSOR^ΛAgi |

[SEQ ID NO:301] = 15 ORF # = 52a

ORF start site = 97076

ORF end site = 95441

ORF sequence:

MSVLGDARHPRRFPSRGPRPFSVAGPGSLPPSPPPGARARLIRLSRSLFPDPTAPMDLLVDDLFADAD GV

SPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWN

ED

LFSGFPTNADMYRECKFLSTLPSDVIDWGDAHVPERSPIDIRAHGDVAFPTLPATRDELPSYYEAMAQ

FF RGELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRNRDLREMLRTTIADRYYRETARLARV

LF

LHLYLFLSREILWAAYAEQMMRPDLFDGLCCDLESWRQLACLFQPLMFINGSLTVRGVPVEARRLREL

NH

IREHLNLPLVRSAAAEEPGAPLTTPPVLQGNQARSSGYFMLLIRAKLDSYSSVATSEGESVMREHAYS RG RTRNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLΞTTAPITDVSLGDELRLDGEEVD

MT

PADALDDFDLEMLGDVESPSPGMTHDPVSYGALDVDDFEFEQMFTDAMGIDDFGG*

Gene matched: gi | 1168549 | sp | P29793 |ATIN_HSV23 Gene name: ALPHA TRANS-INDUCING PROTEIN

[SEQ ID NO:302] = 15 ORF # = 52b

ORF start site = 969103

ORF end site = 95441

ORF sequence:

MDLLVDDLFADADGVSPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLG FS

AGPALCTMLDTWNEDLFSGFPTNADMYRECKFLSTLPSDVIDWGDAHVPERSPIDIRAHGDVAFPTLP

AT

RDELPSYYEAMAQFFRGELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRNRDLREMLRTT

IA DRYYRETARLARVLFLHLYLFLSREILWAAYAEQMMRPDLFDGLCCDLESWRQLACLFQPLMFINGSL

TV

RGVPVEARRLRELNHIREHLNLPLVRSAAAEEPGAPLTTPPVLQGNQARSSGYFMLLIRAKLDSYSSV

AT

SEGESVMREHAYSRGRTRNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITD VS

LGDELRLDGEEVDMTPADALDDFDLEMLGDVESPSPGMTHDPVSYGALDVDDFEFEQMFTDAMGIDDF

GG*

Gene matched: gi | 1168549 | sp| P29793 |ATIN_HSV23 Gene name: ALPHA TRANS-INDUCING PROTEIN

[SEQ ID NO:303] = 15

ORF # = 52c ORF start site = 97097

ORF end site = 95441

ORF sequence:

MRGGGREMSVLGDARHPRRFPSRGPRPFSVAGPGSLPPSPPPGARARLIRLSRSLFPDPTAPMDLLVD

DL FADADGVSPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALC

TM

LDTWNEDLFSGFPTNADMYRECKFLSTLPSDVIDWGDAHVPERSPIDIRAHGDVAFPTLPATRDELPS

YY

EAMAQFFRGELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRNRDLREMLRTTIADRYYRE A RLARVLFLHLYLFLSREILWAAYAEQMMRPDLFDGLCCDLESWRQLACLFQPLMFINGSLTVRGVPVE AR

RLRELNHIREHLNLPLVRSAAAEEPGAPLTTPPVLQGNQARSSGYFMLLIRAKLDSYSSVATSEGESV MR EHAYSRGRTRNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELR LD GEEVDMTPADALDDFDLEMLGDVESPSPGMTHDPVSYGALDVDDFEFEQMFTDAMGIDDFGG*

Gene matched: gi | 1168549 | sp | P29793 |ATIN_HSV23 Gene name: ALPHA TRANS-INDUCING PROTEIN

SEQUENCE LISTING

(1) GENERAL INFORMATION

(i) APPLICANT: SmithKline Beecham Corporation

(ii) TITLE OF THE INVENTION: Novel Coding Sequences from Herpes Simplex Virus Type-2

(iii) NUMBER OF SEQUENCES: 303

(iv) CORRESPONDENCE ADDRESS:

(A) ADDRESSEE: SmithKline Beecham Corporation

(B) STREET: 709 Swedeland Road (C) CITY: King of Prussia

(D) STATE: PA

(E) COUNTRY: U.S.A.

(F) ZIP: 19046

(v) COMPUTER READABLE FORM:

(A) MEDIUM TYPE: Diskette

(B) COMPUTER: IBM Compatible

(C) OPERATING SYSTEM: Windows

(D) SOFTWARE: FastSEQ for Windows Version 2.0b

(vi) CURRENT APPLICATION DATA:

(A) APPLICATION NUMBER:

(B) FILING DATE:

(C) CLASSIFICATION:

(vii) PRIOR APPLICATION DATA:

(A) APPLICATION NUMBER: 60/049,018

(B) FILING DATE: 09-JUN-1997

(A) APPLICATION NUMBER: 60/030,279

(B) FILING DATE: 04-NOV-1996

(viii) ATTORNEY/AGENT INFORMATION: (A) NAME: Geiger, Kathleen W.

(B) REGISTRATION NUMBER: 35,880

(C) REFERENCE/DOCKET NUMBER: P50583 ( ix ) TELECOMMUNICATION INFORMATION :

(A) TELEPHONE : 610-270 -5968

( B ) TELEFAX : 610 -270 -5090

(C) TELEX:

(2) INFORMATION FOR SEQ ID NO : 1 :

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8953 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 1 :

GCGGTCGATC TAGAGGATCC CCCGCGCGCC TGCAGCTGGG TCGCCAGACC CGCGTTCGTC 60

TCTCGCAGGC GTTCTATGGT TCCAAAGAGA TTATTGATAT AGCCCTCCAG CATGCCGTTG 120 ATGTTGTTGA CCACGGCCGT CTGAAACGCC TGGCGAAGCT GCTGCGGTCG CGCCCCCGGG 180

TCCTGGGCCG CCGACCCGCG GCCGGTGCCG CCCTTGCCGA ACCCAGGGAG GGTGTGGTCG 240

ACGGCGGGGG TGTCGATCAG GTGCCCCCCC GCCTCGTCCA AGTAGGCGCG TACCGTGTCG 300

TTGATGTCGC CCACGTGGCG CATGCCCTTC ATGTTGATGA TGAGCCGCAC GAGACACGAG 360

GCGGCCGAGC CGGCCTTCGT CTCGTCATCC TCCCCCAGCG CCTTATTGAC GACCCGCGCG 420 GCGCCAGCCA CCCCGCGCTC GCTGTCGCTC TTGCGCCCCA ACAGCACCTT GACGGACGCG 480

GTGTTGCGCA GACGGCAGAT GTGCGCGTGT TCCCGGAGGG CGTGGCACGC GACGATCTCG 540

GGGCACAGCC GCTGAACGGG CGAATCGAAG ACCAGGCGGT CGCCGGTCCA CAGGGGGGGG 600

CACAGCACCA GGCACTCGCC GCGCTGCCCG CTGACCGGGT CGCGCACCAG CCACTCCCCC 660

CGGCGATGGT TGTAGTAGAT GTGCACACGG TCGTATTCCG CCATGCGCGT GGAGTCGAAC 720 GCGACGGCCA GCTCCAGAAG CCCCGGGCCG GCGCGCTCCG CGGCCCCGGC GACCGTGGCC 780

AGCTGCCGGG GCAGCGTGTG CTGCCTGAGA AACGCCCCCA GGCGCTGCGT CGCCTCCCCC 840

TCGCGCGTCT TGCGCAATAT GGGAACCAGC CCCAGACACG TCAGCCAGTC GATATATTTG 900

GGGAAGCTGG TCGGTCCGCT TGGGCCGCCC GGCGCAAAGC AGTTTACCAC CCCGTGGGCA 960

AAGTCCAGCA GCGTCGTCCT GAGCGTGCAT CGCCACGTGT CGAACACCCG CTCGGCCACC 1020 CCGGCGATAT CGCCCTCCCG GGCGTTCCGG TACCTGCGAA CCAGCCGCTG CGGCTGGAGG 1080

CCGCGGGCCA CCACGTGGCG GCGCCAGTCC TCCTCCAGGT CCCGGTACGT TGTGGCGTTG 1140

AGGAGCGCGT GGAAGATCGC CGCCTGCAGC TGTCGGGTGG CGGCCTCGCT GGACCGGACG 1200

ACGTTGTACA CCCCCTGACC CTCGGTGTAC CCCATCTGCC CGAGGAGAAT CTCGCGGAAC 1260

AACATCGTCC CGGGGGTGGG GTGAACCTTC ACCCAGCCGT CCTCGGGGGC GCATAGCGCC 1320 GCGTCGCCGC CCCGCGTCCG CATCGCCGGC GCCCGCGCGC GCTGTGCGGC CATGGCGGCG 1380

TCCGGCGGGG AGGGCTCGCG GGACGTCCGG GCACCAGGTC CGCCCCCACA GCAGCCCGGG 1440

GCCAGACCCG CCGTGCGGTT CAGGGACGAG GCGTTTTTAA ATTTTACGTC CATGCACGGG 1500

GTCCAACCAA TCATCGCACG CATCCGAGAG CTCTCGCAGC AGCAGCTCGA CGTCACGCAG 1560 GTGCCGCGCC TGCAGTGGTT CCGGGACGTG GCGGCCTTGG AGGTCCCGAC CGGCCTGCCG 1620

CTCCGGGAGT TTCCGTTCGC GGCGTATCTC ATCACCGGCA ACGCCGGATC CGGAAAGAGT 1680

ACGTGCGTGC AGACCCTCAA CGAGGTCCTG GACTGCGTGG TCACGGGCGC CACGCGAATC 1740

GCGGCGCAGA ACATGTACGT TAAGCTCTCG GGGGCGTTTC TGAGTCGACC CATCAACACC 1800 ATCTTTCACG AGTTCGGGTT TCGCGGGAAT CACGTCCAGG CCCAGCTGGG GCAGCACCCG 1860

TACACCCTGG CCAGCAGCCC CGCCTCGCTG GAAGACCTGC AGCGGCGAGA CCTGACGTAC 1920

TACTGGGAGG TGATCCTCGA CATCACCAAG CGGGCCCTGG CGGCGCACGG GGGCGAAGAC 1980

GCGCGAAACG AGTTCCACGC CCTCACCGCC CTAGAGCAGA CTTTGGGGCT GGGCCAGGGT 2040

GCCCTCACGC GCCTGGCCTC GGTCACACAC GGGGCGCTGC CGGCTTTCAC CCGCAGCAAC 2100 ATTATCGTCA TCGACGAGGC CGGGCTCCTG GGGCGGCACC TACTCACGAC CGTGGTGTAT 2160

TGCTGGTGGA TGATTAACGC CCTGTACCAC ACCCCCCAGT ACGCGGGCCG CCTGCGGCCG 2220

GTGCTGGTGT GCGTGGGGTC GCCGACCCAG ACGGCCTCGC TGGAGTCCAC CTTCGAACAC 2280

CAAAAACTGC GATGCTCCGT CCGGCAGAGC GAAAACGTGC TCACGTACCT CATCTGCAAC 2340

CGCACCCTAC GCGAGTACAC GCGCCTCTCG CACAGCTGGG CCATTTTCAT TAACAACAAG 2400 CGATGTGTGG AGCACGAGTT CGGGAACCTC ATGAAGGTGC TGGAGTACGG CCTTCCCATC 2460

ACCGAGGAGC ACATGCAGTT TGTGGACCGC TTTGTCGTCC CGGAAAGTTA CATCACCAAC 2520

CCGGCCAACC TTCCGGGGTG GACGCGGCTG TTCTCGTCCC ACAAGGAGGT CAGCGCGTAC 2580

ATGGCCAAGC TCCACGCCTA CCTAAAGGTG ACTCGCGAGG GGGAGTTTGT TGTGTTTACC 2640

CTCCCCGTGC TTACGTTTGT GTCGGTCAAA GAGTTTGACA AGTATCGACG GCTCACGCAG 2700 CAACCCACGC TGACCATGGA AAAGTGGATC ACGGCCAACG CCAGTCGCAT CACCAACTAC 2760

TCCCAGAGTC AGGACCAGGA CGCGGGGCAC GTGCGCTGTG AGGTGCACAG CAAGCAACAG 2820

CTAGTCGTGG CCCGGAACGA CATCACGTAC GTCCTCAACA GCCAGGTCGC GGTGACCGCG 2880

CGCCTCCGAA AGATGGTGTT TGGGTTCGAC GGGACGTTTC GGACCTTCGA GGCTGTGCTG 2940

CGCGACGACA GCTTCGTGAA GACCCAGGGG GAGACCTCGG TGGAGTTCGC CTACCGGTTC 3000 CTGTCGCGGC TCATGTTCGG CGGGCTGATT CACTTTTACA ACTTTCTCCA GCGCCCCGGC 3060

CTGGACGCGA CCCAGAGGAC CCTGGCCTAC GGCCGCCTAG GGGAGCTGAC GGCAGAACTC 3120

CTGTCGCTAC GCCGGGACGC CGCCGGCGCA TCGGCAACCA GGGCCGCCGA CACCAGCGAC 3180

CGCTCTCCGG GGGAGCGTGC GTTCAATTTT AAGCACCTGG GCCCGCGGGA CGGGGGCCCG 3240

GACGACTTCC CCGACGACGA CCTTGACGTT ATCTTCGCCG GGCTGGACGA ACAGCAGCTG 3300 GACGTGTTCT ACTGCCACTA CGCCCTCGAA GAGCCGGAGA CCACCGCGGC CGTCCACGCC 3360

CAGTTTGGGC TCCTGAAGAG GGCCTTTCTG GGGCGATACC TTATCCTACG GGAGCTCTTC 3420

GGGGAGGTGT TTGAGAGCGC CCCCTTCAGC ACCTACGTGG ACAATGTCAT CTTCCGGGGC 3480

TGCGAGCTGC TGACCGGCTC GCCGCGCGGG GGGCTGATGT CCGTGGCCCT GCAGACGGAC 3540

AACTACACGC TGATGGGGTA CACGTACACC CGGGTGTTCG CGTTCGCGGA GGAGCTGCGG 3600 CGGCGGCACG CGACGGCCGG CGTGGCCGAG TTCTTGGAGG AGTCCCCCCT GCCCTACATC 3660

GTCCTGCGGG ACCAGCACGG CTTCATGTCT GTCGTCAATA CCAACATCAG TGAGTTTGTC 3720

GAGTCGATCG ACTCCACGGA GCTGGCCATG GCCATCAACG CCGACTACGG CATCAGCTCC 3780

AAACTCGCGA TGACCATCAC GCGCTCCCAG GGGCTCAGTC TGGACAAGGT CGCCATATGC 3840

TTCACGCCCG GAAACCTGCG CCTAAACAGC GCGTACGTAG CCATGTCCCG CACCACCTCA 3900 TCCGAGTTCC TGCACATGAA TCTAAACCCG CTCCGGGAGC GCCACGAACG CGATGACGTC 3960

ATTAGCGAGC ACATACTATC TGCTCTACGC GATCCGAATG TGGTCATTGT CTATTAACCC 4020

TCCATTCCCT CGCGTTCCCA CCGCACCCGG GCCGGGTGAC ATTCACCCCC ACCCCCCCGA 4080

GACATGGGGA ACCCCCAGAC GACCATCGCG TACAGCCTAC ATCACCCCAG GGCGTCGCTA 4140 ACGAGCGCGC TGCCGGACGC GGCACAGGTG GTGCACGTGT TTGAGTCAGG GACGCGCGCG 4200

GTTCTGACGC GGGGTCGAGC GCGCCAGGAC CGCCTGCCCC GCGGAGGCGT GGTGATACAA 4260

CACACCCCCA TCGGGCTGCT GGTGATTATC GACTGTCGTG CCGAATTTTG CGCATACCGC 4320

TTTATAGGAC GCGCTAGTAC CCAGAGGCTG GAGCGCTGGT GGGACGCCCA TATGTACGCG 4380 TACCCCTTTG ACTCCTGGGT CAGCTCATCG CACGGCGAAA GCGTCCGGAG TGCGACGGCC 4440

GGCATCCTGA CGGTGGTGTG GACCCCGGAC ACCATCTACA TCACCGCAAC GATCTACGGG 4500

ACGGCCCCCG AGGCGGCGCG GGGGTGCGAT AACGCACCCC TGGACGTCCG CCCAACCACA 4560

CCCCCCGCCC CCGTATCCCC AACGGCGGGC GAGTTCCCAG CAAACACAAC AGACCTACTG 4620

GTCGAGGTTC TGCGGGAAAT TCAGATCAGC CCCACCCTGG ACGACGCAGA CCCAACCCCC 4680 GGAACCTGAA ACCTTCTTTC CTCCCCACCC CGCCCGCTTG CATATTCCCT CTGCGCGCGG 4740

CGACGGCACC GCCGGGCGAA CGAACGGTCA ATAAAATCAA TCAATCCATC ATCCAACAAA 4800

ATAAGCTACG TGTTATTTAT TGAAACGTCA CAACACATCA GTAACGGGGG GAAGGGTAGG 4860

GGGAAAAGAA AGGGGACGGC GGGGGTGCTT AGTCTGGTTC CGTAGACAGC ATGACGTTAT 4920

CTCGATGGAG GCGCATGGGT TCGGACGAAA CAAACTCGTG TACAAACACG GGGACGGCCG 4980 GGCAGAGCCG CCCATCCGAG GACCGCGTGT AATACTTGCG CGGCTTGCGC GACCGAATAA 5040

CCGCCCGCAG CTGCTCGCGC ACCTGCGCGG CGTTGGCGCG CTTGCACAAA ACGAACATCT 5100

GGAGGCTCTT GTTGCTGCGT GGTACGCATG TGCGTTGCGG CGGTGCTCCG CGCTTGCGCT 5160

GGCGCGCGGC CGTCCCCGAA AACGACGAGG TCTTGGTACA CGCGATGCTG AACTTGGCCA 5220

GCGACAGCCG CAGGTCCTTA CGGATCGTAT CCGTGAGCTG GCGGCGCCCC AGTTCGTCGA 5280 TCGAAGATAC CATAAACAGA GTATCAAAGG TGACGTAGGG GCCGTCCGCC CCCGGCGGGT 5340

CGCCGGCCAC GCTCGACGTA AGCGGGGAGA TCGCATCCCG GTCCGGCTCT CCGTCGAGAG 5400

GCCCCACGTG CGCGTCCGGT GCGGTCCCCG CAATCGACTC TATGGGCGTC GTATTCGGCG 5460

ACGCGCCAGG ATCATGGTTC TGGGGTGCAA ACGTCCAGCC CCACGAGGCA AGGATAGTAA 5520

ACGCAGAGGG GGACCCTCTC TTCCCCCACG CCCGACATCA CGGACCGGTA TGAGACCCGA 5580 GATTTAACCA TCAACAGTCT TTAT AATTG CCCCCTCGTA AATCAAGACC CCGGATGTCG 5640

GCATCTTATA CCGACCAGTC GATAGGCATA ATGTCCCGGG TTTCGAGGTA GCGATTCGCG 5700

GCGAGGAAAT GCTGGCACGT CCCAAACGGG ACCTTGGAGA GGGGCGACGG GTGAGAAAAC 5760

TTGAGGACGT AGTGTTGGCG AGGGTCGGGC CTGATCGCGT TCTGGGCATG GGCGCCCCAG 5820

AGCATAAAGA CCAGGCCCGG GCGGCGCGCG GCCAGCCGTC GGACCACCCC GCCCACAAAG 5880 CGGTCCCATC CAAGCTTGGA GTGGGACGCC GCCGCCCCGC GCTTGACGGT CAGGGTCGTG 5940

TTCAACAACA GCACGCCGTC GCGAGCCCAC TTTTCCAGGC AGCCGCGGCC GCTCATGCGC 6000

GCGTCGGGGT AACAATTTTT TACCGCCGCC AGCACGTTCC GTAGACTCGG AGGCACCGGC 6060

ACATCCGCAC GCACGCTAAA CGCCAGGCCG TGCGCCTGGC CGGGATGGTG GTACGGGTCC 6120

TGCCCGATGA TAACCACGCG CACGTCGTCG GGGGTACAAT ACCGCGTCCA GGAGAACACA 6180 TCCTCCCGCG GCGGCAGCAC CTCTTCGGTC TGGCACCGAC GGTCATACTC CGCGAGGAGG 6240

CGCGCGGTTA GGGGGTTCGC GAGCTCCGGC TCCAACAGGG GCCGCCAGGC GTCGTCGATC 6300

AGAAACGCGC GCCGAAACGC GGCCCAGTCC AGGGGCACGG AAGTCGGCAG GGGCGGCGTC 6360

GCATCGCCCG ACAGCCCCAG GGGCTGTTCG GGGGTTGTAG ATGCGGAAAA CATCACGCCC 6420

GGCGGACAGC CTCTAGGGCG ACGACGCTGG ACAGCCGACC CGGCCGCTAG ACGGGTCGGA 6480 TATCCTGCTC CCGACCCAGG GTGGCTTGCG ATGCAGACGT GGCTAGTTGC GTCGGAGGCG 6540

AGTATGCCGG CGCCGACCTC GCGTCGGGGA GACCCGCCGT GGGGGGGCGT TCGAAAGGGC 6600

GAGGACGGGC GGCTGGGTGG CGAGGGGCTT CGACTGCGAG CTCGCTTCAT CGTCCGACGA 6660

CACAGGCGGT TCCCACGTTG ACGTGGTGTT GGCAGGCCGT AAATCGCGTC GCCCGACGCA 6720 GCGGCGAGTG CGTGAGTAGT CAAAGTTTAC ACACCCGGCC CTGACGGGTG CGTGGCTGAC 6780

GGCCTGTTTT CGACTGCCCA ACGCATCGCG TATCTCTTTA TAAAGGGCCC GGCGCGTCGT 6840

TGTTTCCTGG GTGTCGGCCG GAAACACAGA GTGACTCAAG TCCTCCAAAA ATCCCCCCGC 6900

AAAGAGAAAG GGGTTAACCA GATACGCCCT CTGGGCGTGC CTATCCCACA AAAACGTGTC 6960 CAACCCCGGG CAGTGATAGC GAAGAAATAT TCCGTCTATG CGGGCATAGT CAATAACGGA 7020

CGGGGCCTCG TAGCGCCAAG AAACATCGTC CGCGGGGGTC CGCATGCAAG GCACTCTTAG 7080

TATGTCCCCC ACCTCTTTGG CAATAACACT ACGAAGAACA TATTCGGTTG CCTGTGACCC 7140

ACCCCACGCC CCCCAGGGTC CCATAACGAC AAGCCCAAAC AGACAGACGA ACCCCATAGC 7200

GAGCGGACAG TGTAACCGGT AAGCCCCCTT GTTCCCGCAT AAAAAACGTC CAAACAAGAC 7260 AACCGCGAGC AACCGAATCA CGCGGGTCCA ATATGCCCAT TCCCGCGCTT TCTACCGCTT 7320

TATATATCCC CCGTGTCCTC CCCTCCCCCG CGTCCTCCCA TCCCCCGCGT CCTCCCTTCC 7380

CCCGCGTCCT CCCATCCCCC GCGTCCTCCC CTCCCCTGCG CACACGTGAT AGGTTTTGGG 7440

AACCCGAGGG GCGACGCGGG GAAAGCGCGC CCCCGCCCGG CCGCCGAGCG CCCCCGCCCG 7500

GCAGCCGAGC GCCCCCGCCC GGCCACCGCG AGCCCCCGCC CGGCCGCCCG GGTCGCGCCG 7560 GCGCCCCCTC CCGGCGCTTC CGGGGCCTTT CTGTCGTTCC CCGCCGGGAC CCCGGCCCCG 7620

CCCCACCGCC CCGCCCGGCA GGGGGGCCCC GGCGCCGCGC AAAACACACA GACGAACACA 7680

CGGTGGCGAT CTTTTCTTTA CTTCGGCAGA CCAGCGAGCC CCGGCCCCGG CCCGCGCCCC 7740

GCCGCCACAC CCACGGCACC CCCCCCGCCG CCCACCCCGG GGTCCACACA GGAGCGCGCG 7800

GGCGGCAAAA ACGCGGGCGT TTTTTTTTTT TTTTTTTCCC CTTTTTCTCC TCTTTTTCTC 7860 CCCCTCTTTC TTTTCCTTCC CCTTTTTCTT CTTCCCTCTC TCTTTCTTTC TCCTTCTCTC 7920

TCTTCTCTTT CTCTTTCTCT TTCTTCCTCT CTCTTTTCTT CTCCTCCTCC TATCCTCTTA 7980

TCTGTCCACT TCTCCTTCTT TTTTCTTGCC TGCTGTTTCT CTTTTTCTTT CTCTTTCTTC 8040

TATTCTCTGC CTCTCTCCTT CTTACTTCTC TTCCTCTCTC CTATCTACTG TCACTCTATC 8100

TCTTTCCCTT CTTTTATATG TGTCGTATTC ATTCTTTCTC TACTCACGTT ACTCTATCTA 8160 TCTTCTTCAT CATCTCTCTC TCCTACTCTC TCTCCCTCCT TACTACTTCT CTCTTCCTCT 8220

TTTCCTTTAA TATATTTTCT TTCTTTACTC ATCCCTTTTT TCACTTTACT ATTCCATGTG 8280

TATCTCTTCT CTCTTCCTTT TTTCTCTCTC TTTATTTCTC ACTTTCTCCC TCCTCCACTC 8340

TTCTCATCTT TTTTTCTCTA CTCAACATAT CTCTCATCTC TCTCTCTCTA TTTACTACTC 8400

CTACTTCTTT TTTCTCTCTC TCATATTCTA TTTTCACTTT TCTTCCTCCT TCTCATATCT 8460 CACCTCTCGT TCTCTCCCTC TTTTCATTTC ATCTCTTATA TCCTCTCTAT CTTTATTCCT 8520

CCTCTCTCAT TCTCTCTCCT CTGCTCACAC TTACTTACTC CTCCTCTCCA ATTTGTCTCT 8580

TCGTCTCTCA CTCTTCTCCT TTCTCATTTC TTTCTATACT CTCTCTATCT TCGTATCTCT 8640

TTTATCTATC TACTTCTCTA TTCTATCTCC TCTATGCTTG ACTCTCGTTA CATTCTCATC 8700

CCTTCGCTCC TTATCAATTA TCTTCGCACT GCTTANGTAT TCTCTCTCTC TCTCCTCTCT 8760 CTCTCATTTT CTCCTCTCCT GCTTCTCTCT CTTTTCTTGT GGCTCTATCC ACTTCTTCAT 8820

TATATTCTCT CACTTATTTT CTTCTTTCTC TCTCACTGCT CTCTCACCTC TCTCTCTACT 8880

TTCTCTCTTC CTCTGTTTTC TCTCCTCTCT TTGTCTATTC ATCCCCTCTT AACGTTCTTC 8940

TTCTCTTCCG TC 8953

(2) INFORMATION FOR SEQ ID NO : 2 :

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 594 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 2 :

Met Val Leu Met Gly Arg Leu Arg Asn Ala Pro Glu Ser Leu Thr Tyr 1 5 10 15

Met Phe Cys Ala Ala Ile Arg Val Ala Pro Val Thr Thr Gin Ser Arg

20 25 30

Thr Ser Leu Arg Val Cys Thr His Val Leu Phe Pro Asp Pro Ala Leu 35 40 45 Pro Val Met Arg Tyr Ala Ala Asn Gly Asn Ser Arg Ser Gly Arg Pro 50 55 60

Val Gly Thr Ser Lys Ala Ala Thr Ser Arg Asn His Cys Arg Arg Gly 65 70 75 80

Thr Cys Val Thr Ser Ser Cys Cys Cys Glu Ser Ser Arg Met Arg Ala 85 90 95

Met Ile Gly Trp Thr Pro Cys Met Asp Val Lys Phe Lys Asn Ala Ser

100 105 110

Ser Leu Asn Arg Thr Ala Gly Leu Ala Pro Gly Cys Cys Gly Gly Gly 115 120 125 Pro Gly Ala Arg Thr Ser Arg Glu Pro Ser Pro Pro Asp Ala Ala Met 130 135 140

Ala Ala Gin Arg Ala Arg Ala Pro Ala Met Arg Thr Arg Gly Gly Asp 145 150 155 160

Ala Ala Leu Cys Ala Pro Glu Asp Gly Trp Val Lys Val His Pro Thr 165 170 175

Pro Gly Thr Met Leu Phe Arg Glu Ile Leu Leu Gly Gin Met Gly Tyr

180 185 190

Thr Glu Gly Gin Gly Val Tyr Asn Val Val Arg Ser Ser Glu Ala Ala 195 200 205 Thr Arg Gin Leu Gin Ala Ala Ile Phe His Ala Leu Leu Asn Ala Thr 210 215 220

Tyr Asp Leu Glu Glu Asp Trp Arg Arg His Val Val Arg Leu Gin Pro 225 230 235 240

Gin Arg Leu Val Arg Arg Tyr Arg Asn Ala Arg Glu Gly Asp Ile Ala 245 250 255

Gly Val Ala Glu Arg Val Phe Asp Thr Trp Arg Cys Thr Leu Arg Thr

260 265 270

Thr Leu Leu Asp Phe Ala His Gly Val Val Asn Cys Phe Ala Pro Gly 275 280 285

Gly Pro Ser Gly Pro Thr Ser Phe Pro Lys Tyr Ile Asp Trp Leu Thr 290 295 300

Cys Leu Gly Leu Val Pro Ile Leu Arg Lys Thr Arg Glu Gly Glu Ala

305 310 315 320

Thr Gin Arg Leu Gly Ala Phe Leu Arg Gin His Thr Leu Pro Arg Gin 325 330 335

Leu Ala Thr Val Ala Gly Ala Ala Glu Arg Ala Gly Pro Gly Leu Leu 340 345 350

Glu Leu Ala Val Ala Phe Asp Ser Thr Arg Met Ala Glu Tyr Asp Arg 355 360 365

Val His Ile Tyr Tyr Asn His Arg Arg Gly Glu Trp Leu Val Arg Asp 370 375 380

Pro Val Ser Gly Gin Arg Gly Glu Cys Leu Val Leu Cys Pro Pro Leu

385 390 395 400

Trp Thr Gly Asp Arg Leu Val Phe Asp Ser Pro Val Gin Arg Leu Cys 405 410 415

Pro Glu Ile Val Ala Cys His Ala Leu Arg Glu His Ala His lie Cys 420 425 430

Arg Leu Arg Asn Thr Ala Ser Val Lys Val Leu Leu Gly Arg Lys Ser 435 440 445

Asp Ser Gly Val Ala Gly Ala Ala Arg Val Val Asn Lys Ala Leu Gly 450 455 460

Glu Asp Asp Glu Thr Lys Ala Gly Ser Ala Ala Ser Cys Leu Val Arg

465 470 475 480

Leu Ile Ile Asn Met Lys Gly Met Arg His Val Gly Asp Ile Asn Asp

485 490 495

Thr Val Arg Ala Tyr Leu Asp Glu Ala Gly Gly His Leu Ile Asp Thr

500 505 510

Pro Ala Val Asp His Thr Leu Pro Gly Phe Gly Lys Gly Gly Thr Gly

515 520 525

Arg Gly Ser Ala Ala Gin Asp Pro Gly Ala Arg Pro Gin Gin Leu Arg 530 535 540

Gin Ala Phe Gin Thr Ala Val Val Asn Asn Ile Asn Gly Met Leu Glu

545 550 555 560

Gly Tyr Ile Asn Asn Leu Phe Gly Thr Ile Glu Arg Leu Arg Glu Thr

565 570 575

Asn Ala Gly Leu Ala Thr Gin Leu Gin Arg Gly Ser Ser Arg Ser Thr 580 585 590

Ala Xaa

( 2 ) INFORMATION FOR SEQ ID NO : 3 ( i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 877 amino acids

( B ) TYPE : amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:3:

Met Ala Ala Ser Gly Gly Glu Gly Ser Arg Asp Val Arg Ala Pro Gly

1 5 10 15

Pro Pro Pro Gin Gin Pro Gly Ala Arg Pro Ala Val Arg Phe Arg Asp 20 25 30

Glu Ala Phe Leu Asn Phe Thr Ser Met His Gly Val Gin Pro Ile Ile

35 40 45

Ala Arg Ile Arg Glu Leu Ser Gin Gin Gin Leu Asp Val Thr Gin Val 50 55 60 Pro Arg Leu Gin Trp Phe Arg Asp Val Ala Ala Leu Glu Val Pro Thr 65 70 75 80

Gly Leu Pro Leu Arg Glu Phe Pro Phe Ala Ala Tyr Leu Ile Thr Gly

85 90 95

Asn Ala Gly Ser Gly Lys Ser Thr Cys Val Gin Thr Leu Asn Glu Val 100 105 110

Leu Asp Cys Val Val Thr Gly Ala Thr Arg Ile Ala Ala Gin Asn Met

115 120 125

Tyr Val Lys Leu Ser Gly Ala Phe Leu Ser Arg Pro Ile Asn Thr Ile

130 135 140 Phe His Glu Phe Gly Phe Arg Gly Asn His Val Gin Ala Gin Leu Gly

145 150 155 160

Gin His Pro Tyr Thr Leu Ala Ser Ser Pro Ala Ser Leu Glu Asp Leu

165 170 175

Gin Arg Arg Asp Leu Thr Tyr Tyr Trp Glu Val Ile Leu Asp Ile Thr 180 185 190

Lys Arg Ala Ala His Gly Gly Glu Asp Ala Arg Asn Glu Phe His Ala

195 200 205

Leu Thr Ala Leu Glu Gin Thr Leu Gly Leu Gly Gin Gly Ala Leu Thr 210 215 220 Arg Leu Ala Ser Val Thr His Gly Ala Leu Pro Ala Phe Thr Arg Ser 225 230 235 240

Asn Ile Ile Val Ile Asp Glu Ala Gly Leu Leu Gly Arg His Leu Leu 245 250 255 Thr Thr Val Val Tyr Cys Trp Trp Met Ile Asn Ala Leu Tyr His Thr

260 265 270

Pro Gin Tyr Ala Gly Arg Leu Arg Pro Val Leu Val Cys Val Gly Ser 275 280 285 Pro Thr Gin Thr Ala Ser Leu Glu Ser Thr Phe Glu His Gin Lys Leu 290 295 300

Arg Cys Ser Val Arg Gin Ser Glu Asn Val Leu Thr Tyr Leu Ile Cys 305 310 315 320

Asn Arg Thr Leu Arg Glu Tyr Thr Arg Leu Ser His Ser Trp Ala Ile 325 330 335

Phe Ile Asn Asn Lys Arg Cys Val Glu His Glu Phe Gly Asn Leu Met

340 345 350

Lys Val Leu Glu Tyr Gly Leu Pro Ile Thr Glu Glu His Met Gin Phe 355 360 365 Val Asp Arg Phe Val Val Pro Glu Ser Tyr Ile Thr Asn Pro Ala Asn 370 375 380

Leu Pro Gly Trp Thr Arg Leu Phe Ser Ser His Lys Glu Val Ser Ala 385 390 395 400

Tyr Met Ala Lys Leu His Ala Tyr Leu Lys Val Thr Arg Glu Gly Glu 405 410 415

Phe Val Val Phe Thr Leu Pro Val Leu Thr Phe Val Ser Val Lys Glu

420 425 430

Phe Asp Lys Tyr Arg Arg Leu Thr Gin Gin Pro Thr Leu Thr Met Glu 435 440 445 Lys Trp Ile Thr Ala Asn Ala Ser Arg Ile Thr Asn Tyr Ser Gin Ser 450 455 460

Gin Asp Gin Asp Ala Gly His Val Arg Cys Glu Val His Ser Lys Gin 465 470 475 480

Gin Leu Val Val Ala Arg Asn Asp Ile Thr Tyr Val Leu Asn Ser Gin 485 490 495

Val Ala Val Thr Ala Arg Leu Arg Lys Met Val Phe Gly Phe Asp Gly

500 505 510

Thr Phe Arg Thr Phe Glu Ala Val Leu Arg Asp Asp Ser Phe Val Lys 515 520 525 Thr Gin Gly Glu Thr Ser Val Glu Phe Ala Tyr Arg Phe Leu Ser Arg 530 535 540

Leu Met Phe Gly Gly Leu Ile His Phe Tyr Asn Phe Leu Gin Arg Pro 545 550 555 560

Gly Leu Asp Ala Thr Gin Arg Thr Leu Ala Tyr Gly Arg Leu Gly Glu 565 570 575

Leu Thr Ala Glu Leu Leu Ser Leu Arg Arg Asp Ala Ala Gly Ala Ser

580 585 590

Ala Thr Arg Ala Ala Asp Thr Ser Asp Arg Ser Pro Gly Glu Arg Ala 595 600 605

Phe Asn Phe Lys His Leu Gly Pro Arg Asp Gly Gly Pro Asp Asp Phe

610 615 620

Pro Asp Asp Asp Leu Asp Val lie Phe Ala Gly Leu Asp Glu Gin Gin 625 630 635 640

Leu Asp Val Phe Tyr Cys His Tyr Ala Leu Glu Glu Pro Glu Thr Thr

645 650 655

Ala Ala Val His Ala Gin Phe Gly Leu Leu Lys Arg Ala Phe Leu Gly 660 665 670 Arg Tyr Leu Ile Leu Arg Glu Leu Phe Gly Glu Val Phe Glu Ser Ala 675 680 685

Pro Phe Ser Thr Tyr Val Asp Asn Val Ile Phe Arg Gly Cys Glu Leu

690 695 700

Leu Thr Gly Ser Pro Arg Gly Gly Leu Met Ser Val Gin Thr Asp Asn 705 710 715 720

Tyr Thr Leu Met Gly Tyr Thr Tyr Thr Arg Val Phe Ala Phe Ala Glu

725 730 735

Glu Leu Arg Arg Arg His Ala Thr Ala Gly Val Ala Glu Phe Leu Glu 740 745 750 Glu Ser Pro Leu Pro Tyr Ile Val Leu Arg Asp Gin His Gly Phe Met 755 760 765

Ser Val Val Asn Thr Asn Ile Ser Glu Phe Val Glu Ser Ile Asp Ser

770 775 780

Thr Glu Leu Ala Met Ala Ile Asn Ala Asp Tyr Gly Ile Ser Ser Lys 785 790 795 800

Leu Ala Met Thr Ile Thr Arg Ser Gin Gly Leu Ser Leu Asp Lys Val

805 810 815

Ala Ile Cys Phe Thr Pro Gly Asn Leu Arg Leu Asn Ser Ala Tyr Val 820 825 830 Ala Met Ser Arg Thr Thr Ser Ser Glu Phe Leu His Met Asn Leu Asn 835 840 845

Pro Leu Arg Glu Arg His Glu Arg Asp Asp Val Ile Ser Glu His Ile

850 855 860

Leu Ser Ala Leu Arg Asp Pro Asn Val Val Ile Val Tyr 865 870 875

(2) INFORMATION FOR SEQ ID NO: 4:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 199 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 4 :

Met Gly Asn Pro Gin Thr Thr Ile Ala Tyr Ser Leu His His Pro Arg

1 5 10 15

Ala Ser Leu Thr Ser Ala Leu Pro Asp Ala Ala Gin Val Val His Val 20 25 30 Phe Glu Ser Gly Thr Arg Ala Val Leu Thr Arg Gly Arg Ala Arg Gin 35 40 45

Asp Arg Leu Pro Arg Gly Gly Val Val Ile Gin His Thr Pro Ile Gly

50 55 60

Leu Leu Val Ile Ile Asp Cys Arg Ala Glu Phe Cys Ala Tyr Arg Phe 65 70 75 80

Ile Gly Arg Ala Ser Thr Gin Arg Leu Glu Arg Trp Trp Asp Ala His

85 90 95

Met Tyr Ala Tyr Pro Phe Asp Ser Trp Val Ser Ser Ser His Gly Glu 100 105 110 Ser Val Arg Ser Ala Thr Ala Gly Ile Leu Thr Val Val Trp Thr Pro 115 120 125

Asp Thr Ile Tyr Ile Thr Ala Thr Ile Tyr Gly Thr Ala Pro Glu Ala

130 135 140

Arg Cys Asp Asn Ala Pro Leu Asp Val Arg Pro Thr Thr Pro Pro Ala 145 150 155 160

Pro Val Ser Pro Thr Ala Gly Glu Phe Pro Ala Asn Thr Thr Asp Leu

165 170 175

Leu Val Glu Val Leu Arg Glu Ile Gin Ile Ser Pro Thr Leu Asp Asp 180 185 190 Ala Asp Pro Thr Pro Gly Thr 195

(2) INFORMATION FOR SEQ ID NO: 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 172 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 5: Val Gly Pro Leu Asp Gly Glu Pro Asp Arg Asp Ala Ile Ser Pro Leu

1 5 10 15

Thr Ser Ser Val Ala Gly Asp Pro Pro Gly Ala Asp Gly Pro Tyr Val 20 25 30

Thr Phe Asp Thr Leu Phe Met Val Ser Ser Ile Asp Glu Leu Gly Arg

35 40 45

Arg Gin Leu Thr Asp Thr Ile Arg Lys Asp Leu Arg Leu Ser Leu Ala 50 55 60 Lys Phe Ser Ile Ala Cys Thr Lys Thr Ser Ser Phe Ser Gly Thr Ala 65 70 75 80

Ala Arg Gin Arg Lys Arg Gly Ala Pro Pro Gin Arg Thr Cys Val Pro

85 90 95

Arg Ser Asn Lys Ser Leu Gin Met Phe Val Leu Cys Lys Arg Ala Asn 100 105 110

Ala Ala Gin Val Arg Glu Gin Leu Arg Ala Val Ile Arg Ser Arg Lys

115 120 125

Pro Arg Lys Tyr Tyr Thr Arg Ser Ser Asp Gly Arg Leu Cys Pro Ala 130 135 140 Val Pro Val Phe Val His Glu Phe Val Ser Ser Glu Pro Met Arg Leu 145 150 155 160

His Arg Asp Asn Val Met Leu Ser Thr Glu Pro Asp 165 170

(2) INFORMATION FOR SEQ ID NO: 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 334 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 6 :

Met Lys Arg Ala Arg Ser Arg Ser Pro Ser Pro Pro Ser Arg Pro Ser

1 5 10 15

Ser Pro Phe Arg Thr Pro Pro His Gly Gly Ser Pro Arg Arg Glu Val 20 25 30

Gly Ala Gly Ile Leu Ala Ser Asp Ala Thr Ser His Val Cys Ile Ala

35 40 45

Ser His Pro Gly Ser Gly Ala Gly Tyr Pro Thr Arg Leu Ala Ala Gly 50 55 60

Ser Ala Val Gin Arg Arg Arg Pro Arg Gly Cys Pro Pro Gly Val Met 65 70 75 80

Phe Ser Ala Ser Thr Thr Pro Glu Gin Pro Leu Gly Leu Ser Gly Asp 85 90 95

Ala Thr Pro Pro Leu Pro Thr Ser Val Pro Leu Asp Trp Ala Ala Phe

100 105 110

Arg Arg Ala Phe Leu Ile Asp Asp Ala Trp Arg Pro Leu Leu Glu Pro 115 120 125 Glu Leu Ala Asn Pro Leu Thr Ala Arg Leu Leu Ala Glu Tyr Asp Arg 130 135 140

Arg Cys Gin Thr Glu Glu Val Leu Pro Pro Arg Glu Asp Val Phe Ser 145 150 155 160

Trp Thr Arg Tyr Cys Thr Pro Asp Asp Val Arg Val Val Ile Ile Gly 165 170 175

Gin Asp Pro Tyr His His Pro Gly Gin Ala His Gly Leu Ala Phe Ser

180 185 190

Val Arg Ala Asp Val Pro Val Pro Pro Ser Leu Arg Asn Val Leu Ala 195 200 205 Ala Val Lys Asn Cys Tyr Pro Asp Ala Arg Met Ser Gly Arg Gly Cys 210 215 220

Leu Glu Lys Trp Ala Arg Asp Gly Val Leu Leu Leu Asn Thr Thr Leu 225 230 235 240

Thr Val Lys Arg Gly Ala Ala Ala Ser His Ser Lys Leu Gly Trp Asp 245 250 255

Arg Phe Val Gly Gly Val Val Arg Arg Leu Ala Ala Arg Arg Pro Gly

260 265 270

Leu Val Phe Met Leu Trp Gly Ala His Ala Gin Asn Ala Ile Arg Pro 275 280 285 Asp Pro Arg Gin His Tyr Val Leu Lys Phe Ser His Pro Ser Pro Leu 290 295 300

Ser Lys Val Pro Phe Gly Thr Cys Gin His Phe Leu Ala Ala Asn Arg 305 310 315 320

Tyr Leu Glu Thr Arg Asp Ile Met Pro Ile Asp Trp Ser Val 325 330

(2) INFORMATION FOR SEQ ID NO : 7 :

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 183 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 7:

Val Pro Cys Met Arg Thr Pro Ala Asp Asp Val Ser Trp Arg Tyr Glu

1 5 10 15

Ala Pro Ser Val Ile Asp Tyr Ala Arg Ile Asp Gly Ile Phe Leu Arg 20 25 30 Tyr His Cys Pro Gly Leu Asp Thr Phe Leu Trp Asp Arg His Ala Gin 35 40 45

Arg Ala Tyr Leu Val Asn Pro Phe Leu Phe Ala Gly Gly Phe Leu Glu

50 55 60

Asp Leu Ser His Ser Val Phe Pro Ala Asp Thr Gin Glu Thr Thr Thr 65 70 75 80

Arg Arg Ala Leu Tyr Lys Glu Ile Arg Asp Ala Leu Gly Ser Arg Lys

85 90 95

Gin Ala Val Ser His Ala Pro Val Arg Ala Gly Cys Val Asn Phe Asp 100 105 110 Tyr Ser Arg Thr Arg Arg Cys Val Gly Arg Arg Asp Leu Arg Pro Ala 115 120 125

Asn Thr Thr Ser Thr Trp Glu Pro Pro Val Ser Ser Asp Asp Glu Ala

130 135 140

Ser Ser Gin Ser Lys Pro Leu Ala Thr Gin Pro Pro Val Leu Ala Leu 145 150 155 160

Ser Asn Ala Pro Pro Arg Arg Val Ser Pro Thr Arg Gly Arg Arg Arg

165 170 175

His Thr Arg Leu Arg Arg Asn 180

(2) INFORMATION FOR SEQ ID NO: 8:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9218 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 8 :

CCTCCGGACG TGCGATCGGA TCCCGCGAGT CGAAATCCCA CACAGCAGAC CCGTGGGTGT 60 GCTAGATCGA ACGAGCGGCA GGATCGCGTG CTGGCCCCTT GATACGATCT CGTCGACCGG 120 GGACTCCCCT CTACCCCCAC CCAACCAGCG CGCCGGCGCT TAGGGTGTGA CCCCCCCCAT 180

GGCATCCGGG GTTTCCCCGG CCCACCCCCA AACCCCGGTT GGGGCGGGCA GCCGAGACCT 240

TTCCTTAAAA GGCACCCCAT CCGACGGCAT GCAGCCCAGA GGAGCGGACA CGCTTGAAGG 300

GCACTCGCTT CCGACCGACG GGCCCCCGCA CCGGGGCGGC GACCATGATC CGGCGGCGGG 360 GAAACGTGGA GATTCGGGTC TACTACGAGT CTGTGCGGCC CTCTCGATCC CGAAGCCATC 420

TGAAGCCGTC CGACCATCAA GAATTCCCAG GGCACCACGT GTCCCCAGGG AGCCCCGGGT 480

TCCCCGAGAG CCCAGGGAAC CGCGAGTTCC ACGATCTCCC AGAGAACCCA GGGTCCCGCG 540

CATACCCAGG GACCCGCGAC CCCCACGACC CCCACGGGTG CCCAGGGAGC CTAGACCCCC 600

ACGGGAACCC CGCGCAACCC GCGGGCTTGC CTAGCCCGGT CCCCTACGCC CCCCTCGGCA 660 GCCCGGACCC CTCATCGCCG CGCCAACGCA CGTACGTTCT GCCCCGCGTC GGGATCCGTA 720

ACGCGCCCGC GTCCGACACC CGGGCCCCAA AGCGTGCCCA CTCGCGGCAC CGCGCGGACC 780

GGCCCCCGGA GTCCCCCGGC TCCGAGTTGT ACCCTCTCAA CGCCCAGGCC CTGGCGCACC 840

TGCAGATGCT GCCCGCGGAC CACCGGGCCT TTTTTCGGAC GGTGATCGAG GTGTCCCGCC 900

TGTGTGCTCT CAACACCCAC GACCCACCGC CCCCGCTGGC GGGAGCCAGG GTCGGACAGG 960 AGGCGCAGCT GGTTCATACC CAATGGCTTC GGGCCAACAG GGAGTCCTCG CCGCTGTGGC 1020

CCTGGCGGAC GGCCGCCATG AATTTTATCG CCGCGGCTGC GCCCTGCGTC CAAACACATC 1080

GCCATATGCA CGACCTGCTG ATGGCATGCG CCTTCTGGTG CTGTTTGGCG CACGCGTCGA 1140

CGTGTTCCTA CGCGGGGTTA TATTCGGCAC ACTGCCAGCA TTTGTTTCGT GCGTTTGGGT 1200

GCGGACCCCC GGTCCTGACC ACGTCCCGGG GACAGGGTGG TTGGTGTAAT TAATAATAAA 1260 ATCGTGAAAA TTGAAATCGC TTTGTGTGTT GCTGCGGGGA CGGGGGCAAA TGCGTCGTGA 1320

CTCTAGAACG CCAGATGTGG GGTGCGGATG GGGAAATGTA TGGGTCCTTC GTCTGGAGCC 1380

CGTACCCGGC AGAGAGATTT CCCCAGCACG GAGGAACTGG GGTACTGCAC TGCCCCCCTC 1440

CTGGGGGGGG GGGGGGCGAG AGGTCAATAG ATTTCCCCAA GAGACTTCCC TAACACGGAG 1500

GAGCCGGGAG AGTTCAATAG ATTTCCCAAA CACTGAGGAA CTGGGGTACT GCACTGCCCC 1560 CTCCTGGGGG GGGGGGCGAG AGGTCAATAG ATTTCCCCAA GAGACTTCCC TAACACGGAG 1620

GAGCCGGGAG AGTTCAATAG ATTTCCCAAA CACTGAGGAA CTGGGGTACT GCACTTGCCC 1680

CCCCCGGGGG GTGAAATTCC GAGAATTTTT TACCCTTTTT TGCATTTCCT TCCCCCCCCC 1740

CCCCAAAAAA AAAGACAACC TAGTAGACCG TAATGACAAT CAACCACTTT ATTGCAATTA 1800

ACATACGGAC GTGGGTCGCG GCGAGGGGTG GGGGCGAAGA AGGCGCCATA CATCGAGGCG 1860 TCATTTAGCG GAGCAGCCAC ACCAAAAGTG CCCCGAACCC TCCAGATAGG AGGGCCACGA 1920

CGAGACAGGC GATAACCAGC CCGACGCACC GCGTGCGCCG CCGTCGGCGC CTTAGGACCG 1980

ACTGCTGGCG GCCCATGCGC ACGAGGAAGT CGTTGGCGGC CTCGTCTTCG CTTTCCGAGT 2040

AGTAGGCTTC TGCCGGGACG GGCGAGGCCG CGGGGTAAAG CGGCACCGAC GCGCTGGAAC 2100

GCACCGAGTC TTGGTCGGCG GGCCGGGAGG TCATCGCGGA CGCGGAAGGG CGCTGGCGGA 2160 GGGCCGGAGG CGAAGGTGCG GTTGCCGTGA CTCACGATTT TTATGAGCTG CGGCGGGGCT 2220

GGCCGCCGGA CCTTTATGCG CCTCGGGCGA TTGACGTCAC GTAAAACGCA ATCCCGCACA 2280

GGACGGCCCC GAGACCCACC GCCCCCCGCA GCCAGCGCAC GGCGAGCCAG GTGACGAATT 2340

GGGAGGGGGC GTCCACGGCG TGGAGGGCCA CGGGAAAGGC CGCGGGGGAG CCGCCGCGAG 2400

GTGGTCTGCG GCACGCGGGC GCGGCGCCGC CCGCGCCGGG GGGCAGGGTC TCTGGCGGGT 2460 CCCCGCGTGC GTCCGCGATG GCAATCAGTT CATCGCCGAC GTCCGCGTCG TCGGAAGACG 2520

CCTTACCAGA GGACGGACGA ATAGGAGGCC TGGGAGTGAC GACGGCCCGG GCTTCCCGAA 2580

CCAAAGGTGG TGAGCGGGCG GCGAGATTTA CGCCCCTCGC TATGGGGGTA TACAGACGGA 2640

GCCGTTGGTG ATAAGATCTC AAAGCCGGAT CCATTTGTGG AGGGAGAGTC GGGTCTCTCC 2700 GGAGGGTCCT GCCACAGGGA CCCGTCGCGC TCCCCCTCGC TGTCCGAACT CCAGTCCGCG 2760

TACAGCTCGC TGTCCGCCAC GCGAATGTAA GTGGGGCCCG TCGCCGAGGC CCGGCTTTTA 2820

ACCGCCCGCC AGGAGCGCCT GCGCCAGCAG GTCATGCACG CCCACGCGGA CAGCCCGAGG 2880

GCGGCCAGCA ACAGGGCCGC CCCCAGCACC GCCCCGAGGC GCAGCGGGCC GCGCGCGGAG 2940 GGCGCGGGAG GGGGGGCTCT CACGTGCGGG CGGGTGGGCT CGACGGGCTC GGGCTGGCGC 3000

TGGGGGAGGT GCTGTTCCAC CACCGCGTTC CGGTACTGCG CCGCGGTGCT GATGGTCATG 3060

TGGCCCCAGG CGTGGATATG ATCGTCCACG TACACCACGC ACAGGTAGAG GCCGGCGTGC 3120

TGGGGGGAGG CGTGCTGGAA TTCCAGATTG ACGGTGGAGG CCAGCCACGC CAACCCCGGG 3180

ACCGGTTCCA TGCGAGCCTC GGCAAAACAT CGCGGCGGGG GCGTAGTCCT GGAACAGCCG 3240 GCGTAGCTGC GGACCGCCAG GCGGTACGCC CAGGAACTTA CGGCGCACGG CGCGTCGGCC 3300

GGAGATAGAC ACTCTGGAAG CTGCGGGTGA TACAGACAAG CTTCGTAGAT CCGCATCTCG 3360

GCGCACGAGG ACGGCACGTC AAACCGCATC CAGACGACGT CCATGGCGTA CGGACCGTCG 3420

TCGTGGGCTA CGGCGTGGAT GGAGACCTTC GTCTCAAACG TCTCCCCGGG GGCAAACATA 3480

ATGGCCTCCG GGGTCTCCAT ATGGACCGTT ACCCCGCGCA CGTGGGACAC CTCGGGGATA 3540 ACACGATGGT GCCTCGGGGG GGCCACGGGG GGACCAACGG GGGGGGGTTG GGGGGGGAAC 3600

GCTGACCGGC GTGCGTTCGC TCACGCCCGC GTCGTCTTCT TCGTCGTAGT CGTCGGGGGT 3660

CGGGGTCGGC ACAGGGGCGG GCTCCACGAC CAGAACCACC GACGCCACTT GGCGCGCCTC 3720

GTCGCTTAGG CCGACCACGG ACAGGGTGTA CAGACCGCTG TCCGTCTCCA GGGCCCCGTA 3780

GATGACCAGA CTCTCGTTGA CCACGGCTAC GCGATCGCGC CACGCCAACT CCGAATACAG 3840 TCCCTCGTCG CCCGCGGGGA ACGGGGGACT GTATGCTATG GCGAGCGGTT CCGGGGCGCG 3900

CATGCACGCC GCATCCACGA CCGTCTCGAG CACCCGTCGG GGGGGCCACA GCGCCACCCA 3960

CGACGGGCGC AGGGGACCGC AGGCATCCAG GGGTTCCGCG GCCCACAGTA GTTTGTGGGC 4020

CCGGGTGCGT TCCTCCGGCC CCGCGGGCGC CGGAAGCAAC ACCACGTCCT CGCCCGAGGT 4080

TACCCGTTTC CAGGACGTTC TGGGTGCTGC CGCCAGGCAC GATACGACCC AAACTCCAAC 4140 AAAAAACACC AACCCGGCCC CGCGAGCCAT GTTCGGGTGG CAGGAGCCGT CGGTCGGGGC 4200

AGATCGGAGA CTAGCTGACG GCGGCGCACC AAGTCACCCG AAGACACAGA GTCGGGGCGG 4260

CGACTCCTTA AATGCGCGGC GGGCCTCTCC GACACTACCC CCTTTATTCT TTTTCCTCCC 4320

CCCCCGGGCC CCGCCCATCC ATTACCCGCC TCCCATGCCA TCCGGGGAAT GACGAACGAT 4380

CACAAAGGGA TCCAACACAC GCATATAGGC AAATAACATC GGTTTATTGG GGGGGAAATA 4440 ACCACGATGG GGGCGGTGGG GCGGGCCTGC CGAACGGCCC GCTTGGACCT AAACCTCTTG 4500

GGGGGCCGTC GGGCCACTGC GGGGCCGAGG ACTGACGGAC AGCAGCACGA CTGGACCTGG 4560

CTCCGATTCC TCAGCTATCG ACGTTAGGGA AGGCATGGTC GTGGACGACG ACGAACGGCG 4620

TCGGGGTTTG GGGGGGGTGT TTGGGTGGGA TCGCAGCTCG GCTCCGAGGC GGGCCATGGC 4680

CGCCTCGTTG ACCGCGCAGG AAACGCCCCC GGGGTTGTAA ATCTGGCCGC GGGGGCGCCT 4740 GTATCGGCGC TGGCATCTAT GGATGAAGCA GATACAGCTG CCCAGAAACA CAAAGGCGAT 4800

GATGGACGCC GGTATGGCGA TCTGGATTAC CTGGGCTACG GTTAGCCTGT GTCTCGATTC 4860

GCTGGCCGAT CGCGTGGAAT TGGGCGGGGC TCTCTCGCCG CTCGCGGGCG CGGGCGTCCC 4920

TGTGTCCCCG GGGGCGGGGG TCGGGTCTCG GGGGGAGGAC GGGGATGTCG TTGTCCGTGG 4980

AGGGGTGGGC CGGGAGGCTC CGGGGGTGTA TACGCTCGAG GGTCCCAGGC GCGGGGCCGA 5040 AAAGGGAAGC TGCGCCGGAT CGCAGGAGCC GTAGTCCGAG CCGTTATACA CAAACGTCCC 5100

GTTGGCAGAG AGCGCCACCC CCAAAACAAA CAGGCTGGCG TTCGTCGCGC TGCCGACCCA 5160

TACGCGCAGG ACATACAGAC CGGCATAGTC GCGCGTTGCC GTTCGAACCC GCAGAAGCGG 5220

CTGCCGCGCC AGACCCAGCT CCAGGGTCGG ATAGGCGGGG CTGTGGGCGT GGTGCGTCGA 5280 GCGACACAAG GTGAACGCCA CGGCGGGGCG GCGGGGGCAT GCGGTCAGTG TGACCACGTG 5340

TACAACGCGG GGGCAGTGGT TCCCCAGGGG GTAGTGAAAC AGCTCGATGA TGCCGTCGTA 5400

GTAGTTTGTG TGGGGGACCT GGGCCCCCAC AAAATGAAGC TCCCCGAAAA CACGCAGGTC 5460

CTCTTCCACG AAGCCCTGGG GCCCCACGGC CCCGGCATCC ACGAGTGAGT CTGAGACCAG 5520 ACTGACCGTG GGGCCGCGGA CGACCAGGCC GGTGGCGCAG ACCCACAGGC CCAGGATCGC 5580

CAGGCCCTGC AGCGAGCGGC CGGGCATACC GGGATCGGAC GGGTCGAGGT GACTGTGGGC 5640

GCGGTGGCTA ATCGTCGGGA CAGCGGTGCG CGCCCCACGC TCCCGGCCTA TGAACTGTCC 5700

TAGTTTCCCT CCTTCGAGAC TCCCTTTATG CGGAGTCCAA GTCCCACCCA AATACCCCAG 5760

CCACCCTCCC ACACGGGCCC AGAGGTACAC GGGAGCGGGG ATACTCCTCT AGTAAAACAA 5820 TGGCTGGTGC GAGGGGGGCG CGTCGTCATC CCGGATGTGG GGGAGACGTA GGCGCTTGGG 5880

GGCCATCTGA GCGCGGCGGC GTACCCAAAA CGCAATACCG CCGATGACCA GCACCGCCAG 5940

GGTACTGCCG GCCAGCGCGC CGATGATCAG GCCCGGGTTG CTGGGGGCGG CGGGGGCGTG 6000

GTGCGGCGCG ACGTCCTGGA TCGACGGGAT GTGCCAGTTT GGGGGGATCT GCGAAGACAC 6060

CGTCCCGGCG GGATCCTCTA AGAGGGCCGA GTCCTCGGGG TCTTCCGGAA CGAGTTCGGG 6120 TTGCGTGGCG TTGGTGGTGT CGGACAGCTC CGGCGGCAGC AGGGTGCTGG TGTACGGGGG 6180

CTTGGGGCCG TGCCACCCGG CGATTTTTAA GCTGTAT GG GCGACGGTGC GCTGGTTTTC 6240

GGGGATAAAG CGGGGGAGCA TCCCGATGCT GTCGACCGTC ACGCCCTGTT GGTAGGCCTT 6300

CGAGGTGAGG CACGCTGCCG GGGGGATGCG CAGGGGGAGA GCGTACTTGC AGGAGGCGCG 6360

GGCCCGGTGC TCCAAAATAA ATTGTGTGAT CTCCGTCCAG TCGTTTATCT TCACTAGCCG 6420 CAGGTACGTA CCCGCGGTCT CGAAGGCGGG GGCGTGCATC AGGAATCCCA GGTTATCCTC 6480

GCTGACGGCG CTAAAGCTGT CATAGTAGCT CCAGCGGGGC TGCGTTCGGA TGGGGCAGAC 6540

CCCCAACGAC TTGTTGTAGG GGCACTCGGT GTATTCCATA ACCGTGATGG GGATAGCGCA 6600

ATTGTCTCCC ATGCGATACC AGGCGATGGT CAGGTTGTAC GTGTGCTTTC GGGCCTCGTC 6660

CGAAGCCCCG CGCACGATCT GGGGGGCCTC CGATGGGGCA TGTAGGAGCA CGCTGCGGCA 6720 GGCACGTTCC AGCACTGCGT AGTACACAGT GATCGGGATG CTGGGGGGCT GGAACGGGTC 6780

CTCCAGGCTC GGCTGAATGT GGTAAACACG CTTCACCCCG GGGGGGTCGG TCAGCTGGTC 6840

CAAAACCGGA AGGTTCTTCC CGCGAAATCG ATTGGGATCG GCCATCTTAA GCGAGGGGTC 6900

TGCTAAGGCG TATTTGGCGC AGACGACGCG GAGTCCCACC GCGACAACTA GCAGGGCCGC 6960

CGTCCCGACG CCGGAGGTCA AACGCCCCAT GCCGTGATAC GCGATGCACA CGAAAAACGG 7020 CGACTAGTCG TTCGCAATGC AGCTTATGAC CGAACACCAC ACCGACCCCG GGTTTTAAAC 7080

ACAAAGACTC TATTATACTC CTCCTCCTCG TAAAAATGGA ACCTCCCCTC TGGGGGTGAT 7140

TTGGTTGCAT ATGTGGTCGA ATCGGAGTAT GGTGGTGCGG TGGGTCCGCC ATAACCCCCC 7200

TTGTGGGATG GGTTGTGGGC TTGATGTGTT TTTAGTTTCT TTCCCCCCCC CCCCAAGTTG 7260

GTACGCTTGG GGATCGCCGG ATTATTTCGT CTTTCCCGCA CAACCCATGC CCGGCACGGG 7320 GCGTGTGGCA ACAACCAAAG TTATATTACC GACCGCTCCA TAGCTGCTGT ACCCCGGGCA 7380

CCCGACACAC AATCGGGGCG ATGGGGTGGG GGCAAGGCCA GAAAGGCGAA AAATCATGGG 7440

GCAAATTGGC CCGCGTGGGG GCAGCACCTC GCCAACTCGC GACCCAGGCG ACGCAGGACC 7500

TCGAGTAGAC ACGCCATCCC CAGAATCATG AGACACAGCC CCCCCACGAT GAGGGGGACG 7560

GCAAAGCCCC CGGAACGGAT GAGTGGGGGG TGCGTGGGGA GGCGTGCGGT CGCGTTTGTT 7620 GTATCGGACG CGGGGCCGGT GGGTGCGGCC CCAACAGCAG CACACCCGAG GATTCCCACA 7680

ATCCCCCAGG TCCGAACGGC ATACCGATCC ATTGAGACCA AAACAACAGG CACGCCCCCC 7740

GGCGGCGGTC AAGGTTTTTG TTTTTGTTCG GGGACCCGGG TGACTTCGTC TGGGGGCCTT 7800

TCTCTGTGTG GCCAAAAGTT GCGCGTCTCG AGGGCCCCGG GACACGTCTT TTAAAAGACT 7860 CTGTCACCCA CTGATACCTC CCACCCCCCG CCCCCAGTCC CACAAAACAC AACCAAACTC 7920

ACATATCCGA TTGACGTCAC AGGTTTATTG TTCTTATCGT GGCATTTGGT CGCTGTTCCC 7980

TTTCCCGTCC TTCATCGTTT CTCGCCCCCA CCCCACCCCC TAATCCCGCT CGGGTGGCAG 8040

ACATACGTAA CGCACGCTCG GGTGCGCGTA TCGCCTGCGC CCCGCCCGGC CGCGCCAAAG 8100 TTGTGCTGCC AAGGCGACCA GACAAACGAA CGCCGCCGTG TGGATGGTGG TGCTGATGAT 8160

AAAGAGGATA TCTAGAGCAG GGGAGGCCGT TAGGAACCAG AACAGGGGGA TGTGTTGGGG 8220

TGTGGGGCCC GAGGGCATGT CCTTAGCGGG AGCTTGGGCG GGGGGGCGAG GCGTGTTGGG 8280

GGCGAGCGGC CCAAGAATTC CTGGCGGGAG CGTGGGGCGG ATGGGCCCGG GGCGCGCGGG 8340

GGGTGGTTTG TTGGGGTTCG GAGTTCGGAA GGCGAGGCCG GTGGCGCTGT TGTTGTCATC 8400 GGGGGGTTCG CCGTCCCCGG CGCCCTCAAA CTCCTCGGGT CCGCCGCGAT GTTCGGGGGG 8460

TGGGGGGGCT GGCGAGCCGG GGGGAGCGTC CGCGGGTCCG TGTGGGTGCG TCTTTGGGTC 8520

CGTTGGGGGG GTACGGGCGG TGCCCCGGGT TCCGGGCGTG GCGGTGGTCG CGGCAACCGA 8580

AACGTTGGCG GCCGAGGGCC CCGGCGCGGT ACCGGGGGGC GAAGCGGTGA GGGGGGAATC 8640

GGCCGTGGGT GCGGCGGAAG CGCCCACCGG ACCCGGGGTT GCGGGTCCGG GAGGGGTTGT 8700 TTGGGGCCCC GGATTCCTGG GGCGGGGGGT CACGTGGGTA AACGTGGGCG GGGGGGTCGT 8760

GGGGGCTGGT GTGGTGGGGG GCGTTTCCGC TGCGGGGGCG CTGCTGGTGT TCGTGTGCCC 8820

GGCCCCGGGC GTTGCCGCCG CGGCGGGGAT TGGCTACTAC TCCACGGATG CATTCCCGGG 8880

CGGGGATGCA ACTGCCGTTT CCTCCGGCGT AACGGCGACC GTTGCGGCTT GTGTGGCCCT 8940

CTCGTCGGGG GGAGTATTGG TTGCGGGGGC GGTCGGTCCC CCCCTTGGGT TGACTGATGG 9000 CCCCATGGCG GTGGGGTAAA GAGGGAGGGG GGTTTTTTGG AGAGGGGAAG TTGGGGAAGG 9060

GGAGGAAGGT TTNTGGGGGA GGGGTAAGAG GGGGGGNNNG GGNGAGGGGG GGNNAAAGGG 9120

TGGGGGGGAG GGNGGGGGGG GCTGTNCCCA CGCTCCCCCC CCCCCCCCGC CCCGGTTCGC 9180

AAGCGGGCTT TCGTACCTAC ACCCAGGGCC CCCGCCT 9218

(2) INFORMATION FOR SEQ ID NO : 9 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 296 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 9:

Met Ile Arg Arg Arg Gly Asn Val Glu Ile Arg Val Tyr Tyr Glu Ser

1 5 10 15

Val Arg Pro Ser Arg Ser Arg Ser His Leu Lys Pro Ser Asp His Gin 20 25 30

Glu Phe Pro Gly His His Val Ser Pro Gly Ser Pro Gly Phe Pro Glu

35 40 45

Ser Pro Gly Asn Arg Glu Phe His Asp Leu Pro Glu Asn Pro Gly Ser 50 55 60

Arg Ala Tyr Pro Gly Thr Arg Asp Pro His Asp Pro His Gly Cys Pro 65 70 75 80

Gly Ser Leu Asp Pro His Gly Asn Pro Ala Gin Pro Ala Gly Leu Pro 85 90 95

Ser Pro Val Pro Tyr Ala Pro Leu Gly Ser Pro Asp Pro Ser Ser Pro

100 105 110

Arg Gin Arg Thr Tyr Val Leu Pro Arg Val Gly Ile Arg Asn Ala Pro 115 120 125 Ala Ser Asp Thr Arg Ala Pro Lys Arg Ala His Ser Arg His Arg Ala 130 135 140

Asp Arg Pro Pro Glu Ser Pro Gly Ser Glu Leu Tyr Pro Leu Asn Ala 145 150 155 160

Gin Ala His Leu Gin Met Leu Pro Ala Asp His Arg Ala Phe Phe Arg 165 170 175

Thr Val Ile Glu Val Ser Arg Leu Cys Ala Leu Asn Thr His Asp Pro

180 185 190

Pro Pro Pro Leu Ala Gly Ala Arg Val Gly Gin Glu Ala Gin Leu Val 195 200 205 His Thr Gin Trp Leu Arg Ala Asn Arg Glu Ser Ser Pro Leu Trp Pro 210 215 220

Trp Arg Thr Ala Ala Met Asn Phe Ile Ala Ala Ala Ala Pro Cys Val 225 230 235 240

Gin Thr His Met His Asp Leu Leu Met Ala Cys Ala Phe Trp Cys Cys 245 250 255

Leu Ala His Ala Ser Thr Cys Ser Tyr Ala Gly Ser Ala His Cys Gin

260 265 270

His Leu Phe Arg Ala Phe Gly Cys Gly Pro Pro Val Leu Thr Thr Ser 275 280 285 Arg Gly Gin Gly Gly Trp Cys Asn 290 295

(2) INFORMATION FOR SEQ ID NO: 10:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 85 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 10: Met Thr Ser Arg Pro Ala Asp Gin Asp Ser Val Arg Ser Ser Ala Ser

1 5 10 15

Val Pro Leu Tyr Pro Ala Asp Val Pro Ala Glu Ala Tyr Tyr Ser Glu 20 25 30

Ser Glu Asp Glu Ala Ala Asn Asp Phe Leu Val Arg Met Gly Arg Gin

35 40 45

Gin Ser Val Leu Arg Arg Arg Arg Arg Arg Thr Arg Cys Val Gly Leu 50 55 60 Val Ile Ala Cys Leu Val Val Leu Ser Gly Gly Phe Gly Ala Leu Leu 65 70 75 80

Val Trp Leu Leu Arg 85

(2) INFORMATION FOR SEQ ID NO: 11:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 11:

Val His Ala Val Asp Ala Pro Ser Gin Phe Val Thr Trp Leu Ala Val

1 5 10 15

Arg Trp Leu Arg Gly Ala Val Gly Leu Gly Ala Val Leu Cys Gly Ile 20 25 30

Ala Phe Tyr Val Thr Ser Ile Arg Ala 35 40

(2) INFORMATION FOR SEQ ID NO: 12:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 337 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12:

Val Ala Pro Pro Arg His His Arg Val Ile Pro Glu Val Ser His Val 1 5 10 15 Arg Gly Val Thr Val His Met Pro Glu Ala Ile Met Phe Ala Pro Gly 20 25 30

Glu Thr Phe Glu Thr Lys Val Ser Ile His Ala Val Ala His Asp Asp

35 40 45

Gly Pro Tyr Ala Met Asp Val Val Trp Met Arg Phe Asp Val Pro Ser 50 55 60

Ser Cys Ala Glu Met Arg Ile Tyr Glu Ala Cys Leu Tyr His Pro Gin 65 70 75 80

Leu Pro Glu Cys Leu Ser Pro Ala Asp Ala Pro Cys Ala Val Ser Ser 85 90 95 Trp Ala Tyr Arg Leu Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr 100 105 110

Thr Pro Pro Pro Arg Cys Phe Ala Glu Ala Arg Met Glu Pro Val Pro

115 120 125

Gly Leu Ala Trp Leu Ala Ser Thr Val Asn Leu Glu Phe Gin His Asp 130 135 140

Gin His Ala Gly Leu Cys Val Val Tyr Val Asp Asp His Ile His Ala

145 150 155 160

Trp Gly His Met Thr Ile Ser Thr Ala Ala Gin Tyr Arg Asn Ala Val

165 170 175 Val Glu Gin His Leu Pro Gin Arg Gin Pro Glu Pro Val Glu Pro Trp

180 185 190

His Val Arg Ala Pro Pro Pro Ala Pro Ser Arg Pro Leu Arg Leu Gly

195 200 205

Ala Val Leu Gly Ala Ala Leu Leu Leu Ala Ala Leu Gly Leu Ser Ala 210 215 220

Trp Ala Cys Met Thr Cys Trp Arg Arg Arg Ser Trp Arg Ala Val Lys

225 230 235 240

Ser Arg Ala Ser Ala Thr Gly Pro Thr Tyr Ile Arg Val Ala Asp Ser

245 250 255 Glu Leu Tyr Ala Asp Trp Ser Ser Asp Ser Glu Gly Glu Arg Asp Gly

260 265 270

Ser Leu Trp Gin Asp Pro Pro Glu Arg Pro Asp Ser Pro Ser Thr Asn

275 280 285

Gly Ser Gly Phe Glu Ile Leu Ser Pro Thr Ala Pro Ser Val Tyr Pro 290 295 300

His Ser Glu Gly Arg Lys Ser Arg Arg Pro Leu Thr Thr Phe Gly Ser 305 310 315 320

Gly Ser Pro Gly Arg Arg His Ser Gin Ala Ser Tyr Ser Ser Val Leu 325 330 335

Trp

(2) INFORMATION FOR SEQ ID NO: 13:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 226 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:13:

Met Arg Ala Gly Leu Val Phe Phe Val Gly Val Trp Val Val Ser Cys

1 5 10 15

Leu Ala Ala Ala Pro Arg Thr Ser Trp Lys Arg Val Thr Ser Gly Glu 20 25 30

Asp Val Val Leu Leu Pro Ala Pro Ala Gly Pro Glu Glu Arg Thr Arg

35 40 45

Ala His Lys Leu Leu Trp Ala Ala Glu Pro Leu Asp Ala Cys Gly Pro 50 55 60 Leu Arg Pro Ser Trp Val Trp Pro Pro Arg Arg Val Leu Glu Thr Val 65 70 75 80

Val Asp Ala Ala Cys Met Arg Ala Pro Glu Pro Leu Ala Ile Ala Tyr

85 90 95

Ser Pro Pro Phe Pro Ala Gly Asp Glu Gly Ser Glu Leu Ala Trp Arg 100 105 110

Asp Arg Val Ala Val Val Asn Glu Ser Leu Val Ile Tyr Gly Ala Leu

115 120 125

Glu Thr Asp Ser Gly Thr Leu Ser Val Val Gly Leu Ser Asp Glu Ala

130 135 140 Arg Gin Val Ala Ser Val Val Leu Val Val Glu Pro Ala Pro Val Pro

145 150 155 160

Thr Pro Thr Pro Asp Asp Tyr Asp Glu Glu Asp Asp Ala Gly Val Ser

165 170 175

Thr Pro Val Ser Val Pro Pro Pro Thr Pro Pro Arg Trp Ser Pro Arg 180 185 190

Gly Pro Pro Glu Ala Pro Ser Cys Tyr Pro Arg Gly Val Pro Arg Arg

195 200 205

Asn Gly Pro Tyr Gly Asp Pro Gly Gly His Tyr Val Cys Pro Arg Gly 210 215 220

Asp Val 225

(2) INFORMATION FOR SEQ ID NO: 14:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 429 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14:

Val Tyr Leu Trp Ala Arg Val Gly Gly Trp Leu Gly Tyr Leu Gly Gly

1 5 10 15

Thr Trp Thr Pro His Lys Gly Ser Leu Glu Gly Gly Lys Leu Gly Gin 20 25 30

Phe Ile Gly Arg Glu Arg Gly Ala Arg Thr Ala Val Pro Thr Ile Ser

35 40 45

His Arg Ala His Ser His Leu Asp Pro Ser Asp Pro Gly Met Pro Gly 50 55 60 Arg Ser Leu Gin Gly Leu Ala Ile Leu Gly Leu Trp Val Cys Ala Thr 65 70 75 80

Gly Leu Val Val Arg Gly Pro Thr Val Ser Leu Val Ser Asp Ser Leu

85 90 95

Val Asp Ala Gly Ala Val Gly Pro Gin Gly Phe Val Glu Glu Asp Leu 100 105 110

Arg Val Phe Gly Glu Leu His Phe Val Gly Ala Gin Val Pro His Thr

115 120 125

Asn Tyr Tyr Asp Gly Ile Ile Glu Leu Phe His Tyr Pro Leu Gly Asn

130 135 140 His Cys Pro Arg Val Val His Val Val Thr Leu Thr Ala Cys Pro Arg

145 150 155 160

Arg Pro Ala Val Ala Phe Thr Leu Cys Arg Ser Thr His His Ala His

165 170 175

Ser Pro Ala Tyr Pro Thr Leu Glu Leu Gly Leu Ala Arg Gin Pro Leu 180 185 190

Leu Arg Val Arg Thr Ala Thr Arg Asp Tyr Ala Gly Val Leu Arg Val

195 200 205

Trp Val Gly Ser Ala Thr Asn Ala Ser Leu Phe Val Leu Gly Val Ser 210 215 220

Ala Asn Gly Thr Phe Val Tyr Asn Gly Ser Asp Tyr Gly Ser Cys Asp

225 230 235 240

Pro Ala Gin Leu Pro Phe Ser Ala Pro Arg Leu Gly Pro Ser Ser Val 245 250 255

Tyr Thr Pro Gly Ala Ser Arg Pro Thr Pro Pro Arg Thr Thr Thr Ser 260 265 270

Pro Ser Ser Pro Arg Asp Pro Thr Pro Ala Pro Gly Asp Thr Gly Thr 275 280 285

Pro Ala Pro Ala Ser Gly Glu Arg Ala Pro Pro Asn Ser Thr Arg Ser 290 295 300

Ala Ser Glu Ser Arg His Arg Leu Thr Val Ala Gin Val Ile Gin Ile

305 310 315 320

Ala Ile Pro Ala Ser Ile Ile Ala Phe Val Phe Leu Gly Ser Cys Ile 325 330 335

Cys Phe Ile His Arg Cys Gin Arg Arg Tyr Arg Arg Pro Arg Gly Gin 340 345 350

Ile Tyr Asn Pro Gly Gly Val Ser Cys Ala Val Asn Glu Ala Ala Met 355 360 365

Ala Arg Leu Gly Ala Glu Leu Arg Ser His Pro Asn Thr Pro Pro Lys 370 375 380

Pro Arg Arg Arg Ser Ser Ser Ser Thr Thr Met Pro Ser Leu Thr Ser

385 390 395 400

Ile Ala Glu Glu Ser Glu Pro Gly Pro Val Val Leu Leu Ser Val Ser 405 410 415

Pro Arg Pro Arg Ser Gly Pro Thr Ala Pro Gin Glu Val 420 425

(2) INFORMATION FOR SEQ ID NO: 15:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 392 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 15:

Val Cys Ile Ala Tyr His Gly Met Gly Arg Leu Thr Ser Gly Val Gly

1 5 10 15

Thr Ala Ala Leu Leu Val Val Ala Val Gly Leu Arg Val Val Cys Ala 20 25 30

Lys Tyr Ala Asp Pro Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg

35 40 45

Gly Lys Asn Leu Pro Val Leu Asp Gin Leu Thr Asp Pro Pro Gly Val 50 55 60

Lys Arg Val Tyr His Ile Gin Pro Ser Leu Glu Asp Pro Phe Gin Pro 65 70 75 80

Pro Ser Ile Pro Ile Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys 85 90 95 Arg Ser Val Leu Leu His Ala Pro Ser Glu Ala Pro Gin Ile Val Arg 100 105 110

Gly Ala Ser Asp Glu Ala Arg Lys His Thr Tyr Asn Leu Thr Ile Ala

115 120 125

Trp Tyr Arg Met Gly Asp Asn Cys Ala Ile Pro Ile Thr Val Met Glu 130 135 140

Tyr Thr Glu Cys Pro Tyr Asn Lys Ser Leu Gly Val Cys Pro Ile Arg

145 150 155 160

Thr Gin Pro Arg Trp Ser Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu

165 170 175 Asp Asn Leu Gly Phe Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly

180 185 190

Thr Tyr Leu Arg Leu Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gin

195 200 205

Phe Ile His Arg Ala Arg Ala Ser Cys Lys Tyr Ala Leu Pro Leu Arg 210 215 220 lie Pro Pro Ala Ala Cys Leu Thr Ser Lys Ala Tyr Gin Gin Gly Val

225 230 235 240

Thr Val Asp Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gin

245 250 255 Arg Thr Val Ala Lys Leu Lys Ile Ala Gly Trp His Gly Pro Lys Pro

260 265 270

Pro Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Asp Thr Thr Asn

275 280 285

Ala Thr Gin Pro Glu Leu Val Pro Glu Asp Pro Glu Asp Ser Ala Leu 290 295 300

Leu Glu Asp Pro Ala Gly Thr Val Ser Ser Gin Ile Pro Pro Asn Trp 305 310 315 320

His Ile Pro Ser Ile Gin Asp Val Ala Pro His His Ala Pro Ala Ala 325 330 335 Pro Ser Asn Pro Gly Leu Ile Ile Gly Ala Gly Ser Thr Leu Ala Val 340 345 350

Leu Val Ile Gly Gly Ile Ala Phe Trp Val Arg Arg Arg Ala Gin Met 355 360 365 Ala Pro Lys Arg Leu Arg Leu Pro His Ile Arg Asp Asp Asp Ala Pro

370 375 380

Pro Ser His Gin Pro Leu Phe Tyr 385 390

(2) INFORMATION FOR SEQ ID NO: 16:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 16:

Val Gly Gly Leu Cys Leu Met Ile Leu Gly Met Ala Cys Leu Leu Glu 1 5 10 15 Val Leu Arg Arg Leu Gly Arg Glu Leu Ala Arg Cys Cys Pro His Ala 20 25 30

Gly Gin Phe Ala Pro 35

(2) INFORMATION FOR SEQ ID NO: 17:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12489 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 17:

GAAAAGGGGG AAGGTGAGGG ATAGGGAAGG AAGAGGAAGG ATAAGAAGTG AAGAAAAAGG 60

GAAGAGAAAA GATAGATATG GGGAGAGGAG GAAGAGAGGG GGTGAAGAAG GGAGAAGAGG 120

GAGAGGAGAG GTAAAGAGGG GAGAGGAGGT AGGAGTGGAA GGGAAGAAGA GAGGAAAAGG 180

GGGGGAGGGA AGAGGGGAGG AGCGGCCGAA GCCGGAATGA CAAACAGACG AAGCGACTGG 240 GGGAGATCCC CCCGCCCCCG AGGACAGCTT TTCCGGGACC TATCCCCGCC ACCGCCGTAT 300

AAGCTCGTCT CCACGGTCGA TATCCCCCAC CCCGAGACAC CCCGGAGAAC ACCGAGCGGC 360

CGACAGGCCA CGGACCCCTA TTGCCGTCGA CACACCACCA GCAATCTCCG CGGATGTGCA 420

GCGACGNGAC CACACCGCCC GAAAACATCT GANTTCCCCT ATGACCTTTC CCACCACCCT 480 CGCGCGGCGC AGGCGGCCAG CGCGAGCGCG CCCGCAAAGG TCACCACGGG AACCCAGATG 540

TTTTCGGGCC GTGCGGCCCC GTCGCCGCAG ACCCGCGGAG ATCGCTGGTG GTGCGTCGAC 600

GGTAACAGGG GTCCGTGGTC TGTTGGCCGC TCGGCGTCCT CCGGGGCGTA TCGGGGCGGG 660

GGAGACTCGA CCGCGGAGAC GACGCAAAAG CGGCGGTGGC GGGGACAGGC CTTGGAAAAG 720 CTGTCCCCGG CGGCGGTTGT CCCGAGGCCC GCCACCACCG CCGCCGTCAG GGCCGCGGCG 780

GCGCGGGGGT CAATCCACCA GTAGCGCGCA CTGCCGCCTA TCGTCAGCCC GCCGACGACA 840

ACCCCCAGGG TGCCGACAAA CAGGGGCCGC GGGGCGAGGA GGAAAAGGGG ATGGACGTCG 900

TCGGCCAGCA CCAGCAGCGC CGCGTAGGCG GCCCCGAGCG CCAGGCACTG GGTCGCCGGG 960

CCCGGAACCC CCGGAGGCGC GCCGGCCTCC CCGAGGCTCC ACAGGGCCAC GGCCGCTCCC 1020 CCGCCGACCA GCCTCAGCCA CGCGCACACA CGCGTCGGCG GCCGGGCGAA CGCGGGGGGG 1080

GCGCGGAGGA ACCCCAGGCC GGTGCTCCCG ATCACGAACG CCCCCGACAT GGCGTCCGCA 1140

TACGGGCCGC GCGACAGAAC GACAGACCCC ACGAAGCCCA GCGTGGTGGC CTGGAGCCAG 1200

AGATGCGCGA ACCCCCGAGC GATGGCACCC ACGCAGGCGA GGCGGGGGCG CCCGTCGTCC 1260

CCATCATCCC CTCCGAGGCA GTGTTCGCCG CTCCCGCCCG CGACCCCGGG GCTGTCCCCG 1320 CGACACATCC CGCACCCGGG GCCCGACGGC GCTCTCGGTG AAGCTGCGAA GGGCCCCGGG 1380

CCCGCTCTTA TAAGCGCACG CAAAACAAAA AAGGAGGGGG AAGGGGGGTG GAAAGGACGG 1440

AGGCGCAACC CGGAACCACA CACAACAGCC ATATTGGTTG GAGGGGGGGG ACACACTACC 1500

CCATTTATTT ATTTTTTTAA CACAACGCAC CCCGCGTGCC CGGGCGCGGT GAACCGTTCG 1560

GCCACCACCC GTCGCCGTCA GGGCAACCCA AAACCGTATG GGGGTCTTTG GGGACCCCGG 1620 AAGGCGGAGA GGGGGCTGGG GCTCGCGTCG CCGGTCTGGA GGTCGCGAAA GTACCACGCG 1680

TAGCGGCCGC CGTCCCCACC ACCCTCCGCC GCCTCGGGTC CG ATCTCGC GGAGAGGGGG 1740

GGCGACTCGG CTCGCGTGGG GGCGGCGGGC ACGCCCGTCT TCGGGCGCTT GGTGGCGTCA 1800

TCCGCGGGGA CAACTTCGGC CCCGGCGTGC CTCCGCTTGG TTCCCGGCGG TTCCGGGAAC 1860

GCGGGCGGGA CCCGGGCCTG GCCCTCGAGG CCTTCTTCTT CTGGGGCGCC GCGGTCGCCC 1920 GCGTCCGGCT CGGAGGAGAA GTCCTGGCTG TCGGTCGGGC CGGCCCGAGA GTCCTGGGAC 1980

GCCAAGCTCC CGGTCGAGGA ACCCGGGGTC CGGCCGAGCC AGTTCAGGCA GACCCGCTGG 2040

GGTTTTAAAA GAAACACCGC CGACACCGCG TTGGGGCCGG TGGCGGTGAC ACACACGCTG 2100

GGGACGTCGG CCGTGAGGAA GAAATTGAGG GTCCCCCCGC CGACCTGGAG CCGCCGGAGG 2160

ACCGCCCGCA TGCTGCAGTC GTCGACGACC ACCGAGAATG TGCGGTGTGT GTTTTCCCCG 2220 TAGACCGTCT TGGCGTTGGC GGCCGCCTGG CCCGCCTTCT TCAGCGCGCT GGTCAGAATC 2280

TGGACCTGGG CGCTGGTGCT GGACGACGCG CCCTCCTCGC GGGCGGCAAA GGTGACGCAG 2340

GTGCGCGCGT TAAACACGGA AAACTTGCCG TTGGGGCCGA GCTCGAACGT GGTGGGTTTG 2400

GCGGTCTCGT CCCCGACGGC GTTCACCACC TTCGTGAGCT GGGGCTTCGT GAGGCGCAGC 2460

TGGACGTCGG GGTCGCCCTG GGGGAGTAGT ACCGCGAAGC TCGTCAACTC GCGTTTCATG 2520 AGCGTCTCGC TGGCAAGCTC CACGGCCTCT CCGTCGGACG CGGTCGTCCA TATGCGCTGC 2580

ACCAGCGTGC GAAACGGGGC CTGGCCCGTG ACCGTCAGCT CCACCCGCCG CAGGTCAGGG 2640

TACTGGTTGG CGCGAAACAC GCTCAGCAGG GATCGCTTCT GGTCCACGAG AGACAGGAAC 2700

GCCGCGGTGG GTCCGCCCCA TCGATAGCGA CTGAACTGCG AATGGTCGAG GGGCAGAAAC 2760

ACCTGCTCGC CGAAAATCGC GTTATGTACA AGGATGCCTC GGTCGCCCAC GACCAGGAGC 2820 GAGTCCAAAA GGCTCGTGCG AAGCGGCGCA AAGGCCTGCA GGATCCCGTT CAGCTCGGCG 2880

CCCTGCAGCA CTATCTGGCA GGGCGGCCAG TCTTCCGTCC GCTCGCGCGG CGACGGGATC 2940

GCGTCCTCCG AAAGGGGGGC GGCGGCCGCA CCGCCGGGAA GATGAGCCAT GCCGCGACGC 3000

TCCCGGGACA ATCCGCAGAG ACGAGGCGCG TCGTGTCACC GGGCCCGGAG GCGCGGCCGT 3060 TTGTGTCGCA GGCGGAGGGG GCGGATGACG CGGACCGGAT GGGGGTTAGG GGGGCCGGGG 3120

GACCCGAGCC ACAGAGCAGT GGCTACCCGA GCCAAGGACT ACGGCGGACC CGCCGCCCTA 3180

GTTTGGTTAA ATACGCCTTC CGCTAGTTAG GCCACACCCT CTTTGAGGGC TCGGGGGAGG 3240

GGGAGGGGGG GAAGAGAGAG ATGGTCGGCC TGCACCGGCG CGCGCCGGCG GTTGCACCAA 3300 TCCGCACGTA GATGGGAAAT AAAAAAGAAT TATAAAGAGC GTGCCTTTCC CGGGATAGCG 3360

TCTTGTTGGA GCGGGGTCGT CGCCGCAGCC ACTGTACACA GGGGCGGCGG GCTTGGGTGT 3420

CCCGGACCGT CACACCTATA CAGCTCTGTA GAGAGACCTA TCCGCACCTA CAATCGTGCC 3480

GGAATGGGTC TGTTTGGCAT GATGAAGTTT GCCCAGACTC ACCATCTGGT GAAGCGCCGG 3540

GGCCTCCGGG CCCCGGAGGG GTACTTTACC CCCATCGCCG TGGACCTGTG GAATGTCATG 3600 TATACCCTGG TGGTTAAATA TCAGCGCCGC TACCCAAGTT ACGACCGCGA GGCAATCACG 3660

CTACACTGTC TCTGTAGTAT GTTACGGGTG TTTACCCAAA AGTCCCTGTT CCCCATCTTC 3720

GTGACCGATC GCGGGGTCGA GTGTACCGAG CCGGTTGTGT TCGGGGCCAA GGCGATCCTG 3780

GCCCGCACGA CGGCCCAGTG CCGCACGGAC GAGGAGGCCA GTGACGTAGA CGCCTCGCCG 3840

CCGCCTTTCC CCCATCACCG ACTCCAGGCC CAGTTTCCCC CTTTCCAACA TGCGCCGCCG 3900 CGGGCACGCC TTCGCCCCGG GGGACCGGGG GAACGCGGGC CGCCGGCCCA GGCCCGGCGG 3960

CCCCCTGGGG CGCGCCCTCG AAGCCGGCCC TGCGCCTGGC TCACCTGTTC TGTATCCGCG 4020

TTCTGCGGGC GCTGGGGTAC GCCTACATCA ACTCGGGTCA GCTGGAGGCC GACGACGCCT 4080

GCGCGAACCT CTATCATACC AACACGGTCG CGTACGTGCA TACCACGGAT ACCGATCTCC 4140

TGCTGATGGG CTGCGATATC GTGTTGGACA TCAGCACCGG CTACATTCCG ACGATTCACT 4200 GCCGCGACCT GCTGCAGTAC TTCAAGATGA GTTACCCGCA GTTCCTGGCG CTGTTCGTCC 4260

GCTGCCACAC AGACCTGCAC CCCAATAACA CCTACGCGTC CGTCGAGGAC GTGCTGCGCG 4320

AGTGTCACTG GACCGCCCCG AGCCGATCCC AGGCCCGCCG GGGGGCCCGG CGGGAGCGCG 4380

CCAACTCGCG CTCCCTGGAG AGCATGCCTA CGCTGACCGC GGCCCCGGTC GGCCTCGAGA 4440

CGCGCATCTC GTGGACCGAA ATTCTGGCCC AACAGATCGC GGGCGAGGAC GACTACGAAG 4500 AAGACCCCCC CCTCCAGCCC CCGGACGTCG CCGGTGGGCC GCGCGACGGC GCCCGGTCGT 4560

CCTCCTCGGA GATACTCACC CCGCCCGAGC TCGTGCAGGT CCCCAACGCG CAGCGGGTCG 4620

CGGAACACCG CGGCTATGTC GCCGGACGTC GCCGCCACGT CATCCACGAC GCCCCGGAGG 4680

CCCTGGACTG GCTGCCCGAT CCGATGACCA TCGCCGAGCT GGTGGAGCAC AGATACGTCA 4740

AGTACGTCAT ATCGCTTATC AGCCCCAAGG AGCGGGGACC CTGGACTCTT CTAAAAAGAC 4800 TGCCCATCTA TCAGGACCTC CGCGACGAAG ATTTAGCGCG CTCCATCGTG ACTCGGCATA 4860

TCACCGCCCC GGACATCGCC GACCGGTTTC TGGCGCAGCT GTGGGCCCAC GCGCCCCCGC 4920

CCGCGTTTTA CAAGGACGTC CTGGCTAAAT TCTGGGACGA GTAGCCGGAA CGGAGGAAAC 4980

GCGCGCCCCC ATCCCCTCCC GATGCCCGAC CTGTTAATAA TAAGAGTAAT AAAATCGTTT 5040

GTTATTATGC ATCTCGGGGT TCTGGTCGGC GCTTGATTTA TCGGTTGGAC GCGTTTCCCT 5100 TTTGGTCCTT TTCTCTGGTT TCGGGCGTTC CTTCCCTTTC CCCAGCCGCC ACCCCCCTCC 5160

CCTGCGTAAT AATCACACCG GAGACCCAAC AGTCCGTTTC GACCCCTTTA TTTCGGTTAG 5220

ACATCGCTAC AAGGGCGCCC AGACCCTCAC AGATCGTTGA CGACGGCCCC GGCGTACGAG 5280

GTGCTGCGGC ACTCGAAGAA GTTGGTGTGT TTGTCGGTGG ACATGAGGCT GAGGGGAAAG 5340

CTGGCGTCGG GGGCGGGGGC GGAATACAGG GGCTGCATAT GGATCAGGCC CAGCAGGCGA 5400 TCCGCGCTGA ATCGCACGTA GTTCTCGATG GCCGCCAGGG CCCCCGGACT CAGGATAGAG 5460

CTGTCCGTCG GGGCCTGGGA TCGGATGAAC CCGATCTCGA TATCCACCGC CTCCCGAAAC 5520

AGCCGGTACA CGCGCGCCGC CTCGGGCTTG GCGTGGCCCC CGAGGTAGTT GTTGTAGATG 5580

TAGCACGAGG CTGTCGTATG CACGGCCTCG TCGCGGCTGA TGAGGTCGTT CGACTGGCAG 5640 GTGACCCGCA GGAGGTTGTT GGTGCGCAGG TACGCGATGG CGGCGAACGA GGCGGCAAAA 5700

AAGACGCCCT CGATGAGGAT CATGAGGATG AACTTCTCCG GGATCGAGTC GCATTCCCGC 5760

ACCCGCGCCT CCAGCCAGTC CACCTTGACG CGAATGGCCG GGTGGTTGAT GGTGCGGGCC 5820

ACATAGGCGC GGCGCGCCTG GTCGTTGTTG TGAAAGAGCA CCAGCTGGAT GATGTTGTAG 5880 ACGCGCGAGT GGACGACCTC GATGCATTCC TGCTCCACGT AGTAGTGAAG AATGTCCTTC 5940

TGTTCGAAGA GGCCGGAGAG GCCGCCCAGG TTTTCCGTCA CCAGGTCGTC CGCGGCCGAC 6000

AGGAAGGCAA ACAGAAAGCG GTAGAAGCCG AGCTCGCCCT CGGAGAGCTT GGAGACGTCC 6060

TCCTCGTCCC CCACGAACAC GAGCTCGGTC TCCAGCCAGC GGTTCAGGAT GCTGAGGGAG 6120

CGAAGGTGGT TGATGTCGGG GCACTGGGAG GTGTAGAAGT ACCGCTCGGG GGTGGGGCAC 6180 ACCGGAATCG GGGCCGCCCC GGCCCCCGAC GCGTGGGTAT CTAGGGGGTC GGTGCTCGCG 6240

GGGGAGACGG CGGGATCCAT GGCGATATGC GGGACCGAGA GCGACGCCTG ACCCCGATCG 6300

GAGCGCTGTT GCTTACAGCG CGCAGCTTGT GCAGACGATG TTGTCGTCGC CGGCGAACAC 6360

CCCGCTGTTG GTCGCCTTGC GAACCTTGCA GTAGTACATC CCCGTCTTCA GGCCGCGCTT 6420

ATATGCGTGG ACGAGAAGGC GGACCAGGGT GGAGGCGGGG AGCGTCCCGT CCGCCTTCTC 6480 TGTGACATAC AGAGTCATGG ATTGGCTGTG ATCAACATAG GGGGCGCGGT CTGCACACAG 6540

GTCGATCAGC AGTTCCTGGT CGTAGTCGAA GGCCGTCTTG AACCGCCGGA GGGGGTGGGC 6600

GGGGTCCAGG CAAGGCAGGG CCTGGGCCAC AGACCACTGC TTGGCCTCGA GCCCGTCCAT 6660

CGCGTCCAGG AGCCGCTTCC CGCCGAACGT GCGCTCGAGT TCCTTCAGCA AGAGCGTGTT 6720

GGGGCGCAGC GTCTCGCCGT CCCTGGTCAC CTTGCTGAAC AGGTTGGTGA ACAGGGGGGC 6780 AAAGCCCTCG CTGACGTCCG AGATCTGGGC CGAGGCGGCG GTGGGCATGA GCGCGATGAA 6840

CTGGCTGTTG CGCAGGCCGT GTTTCATCAT GCTCTGGCGT AGCATCTCCC ACTCGCCCTC 6900

GTACCGCGGG CTGGCGTTCG AAAAGCGCTC CCAGTGAAAG CGGCCGGCCC GGTACATGCT 6960

GCGCTTAAAG TGGCTGAAGG GACGCGCCCC GCGAACGCAC AGCGCGTTAC TGGTCTTCAT 7020

GGCCGCGAGC AGCATCACCT CGGCGATGTG TGTGTTCAGG TCCCGGAACT CGGCCGACTC 7080 CAGATCCAGG CCCATCTTCA GGCACGCCGT GTGCAGGCCC TGCATGCCAA TGCCCATGGA 7140

CCGCAGGTTG TCGTGGCCGC GGGCGCACTG GGGCGTCGGC TGCAGCGTGC TGTCTATCAT 7200

GATATTAACC ATTAGCACGC ACGCCTGCAC GGCGTCGCGG AGCATGCCAA AATCGAACGT 7260

CCGCCGGGAG ACGCATCGGG CCAGATTCAC GCTGCCCAGG TTGCAGACCC CGCTGGAGCG 7320

TTTGGAGGAC GGGTGGACGA TTTCCGTGCA GAGGTTGGAG CCGGCAATGG CCGCCCCTTG 7380 CGTGTTGTAG ATGTAGTGGC GGTTTACCGC GTCCTTAAAC ATGATGAAGG GGCTTCCGGT 7440

GGTGGCCGCG CTGCGCACGA TGGCGTACGC CAGGTCCTGG ATGGGGATCG TTTCGCCGAA 7500

CCCCATGGCC TCGAGGTGCT CGTACAGCTT CTCGAACTCC TCGCCGTGAA AGTCGGCGAG 7560

CGACATGCTG GTGTCCCGGT CGAACAGGGA CCAGGTGACG TTTTCCTCGC CGTCGAGGTG 7620

GCGGATCAGG CGCTTGAAGA ACAGGTCCGG CATCCAGAGG GCGCTGAAGA TGTTGTCGCA 7680 GCGCTGGGCC TCCTCGCCGG CGAGGACGCC CTTCATTCTG AGCACGGCCC GAACGTCGCT 7740

GTGCCAGGGT TCCAGGTACA CGCACGCCCC GGTGGGGCGC GTGCTCTGTT TGTTGTGCGC 7800

CGCCACCAGG GAGTCCAGGA CCTTCAGGGC CGGCATGATG CTGGCGGTGC CGGGGCTGGC 7860

GTCGTTGAAC GCCTGCATGC ACAGCCCGAT GCCCCCGTTG CGGGCGAGGA TGGCGCTCAC 7920

GTTGCCGGTG ATGGCCCGGA GGGTGGCCTG GTTAGTGGTG GCCTGGGGGT TTACCAGGTA 7980 GCAGCTGGAC GTGTAGTAGT TGCGGGTTCC GAGGTTCAGC ATGGCGGGGG TGGACGGCAC 8040

GATCTGGTGG TCGTAGAGGC GGTGGAAAAA GAACTTGAAC ATTTCCCACC ACGACCCCTG 8100

TCGCCCCAGG GCGATGTGGC GCATGCCGCG GGTCGCCCGG CACGCCAGGA ACCCGGCGAT 8160

GCGGGTGTAC ATCTGGAAGA CGGACTCCAT GTAGTGCCCG CCGAAGCGCT TGAGGTAAAA 8220 CTCTTCGTAC TTCAGCGCCG ACTGCAGCCC CCGCTCGACG AGCGTGTTCG GGGTGCTGTG 8280

GATCAGACAG TCGTAGGGGT TCAGGGCCTG GGCCAGGATC ATTAGCTGGG CCTCGTGTTC 8340

GCGAAGCCTT TCCGTCAGCC CGAAGTCCAG GTCCACCTCC TTGGAGCGCA TCCATTCCTC 8400

AAAGGAGGCC TCCCGGGTAC GGATGCGCAG GTGAACCAGA ATCCCCAGGA TGCGATACAG 8460 GCGGGCGGAC CGCCGCACCA GGGGTTTGAA CCCGTTAACC AGCCGCGTCG CATACTCCCT 8520

CAGATGATAG GGCGTGTATG CGTTGGGGGG GACCGGGGGA AGGTCCAGGC ACAGGCGTCG 8580

CATCTCAGCG AGCGCGTAGT TCAGGAGCCC AAAGTCGTCC TCCGTGAGGC GGGGGGCGCT 8640

GCCGAAGGTT CGTGGGGGCA CGCGCTTGCT CTCCTCGCGG GCGCACCGAC AGAAGTACTC 8700

CAGCATGAGC GCGGGCTCGC GGTCGACGGC GTCCCCCAGA AACCGCGCCA CCGCCTCCGC 8760 GTTCTCGGGC GTGAGTTCTA GGGGGACTGG GTAGCCGGGG TCCGTCCCCA CAGTGGGCTG 8820

GCTGTCCAGA ACCGGCGCCA CTTCCGCCTG GGGTGCGGCG GCGTGGGCCG CGGAATCGGA 8880

GTCGGCCGAC GCGCGCGGGT CCGTCGCGGA GCCCGGCCCG GTGCCGGCGC CCAGGCCGGG 8940

GTTTCCGGGG GAGTCCCCGG GGCGCCGGGG CTTGGGAAAG GCCACGGGGG CAGGGCCGTC 9000

GCTCCATCTG CGACGAACGA CAACGTCGGG CTGCACGGAG TCGTCCGACC GCGAGTCGGA 9060 GTCGCTGTCA TCGTCGTCAG TCGCCCCTGC GGCCCAGATC GAAGAGGATC GAGACAGCGT 9120

CTCCGAACCC GAGCCCGTAT CCTCGTCCGA GGAGTCCGAG TCCTCCGTTT CGGAGTCGGA 9180

CGACGGGCCG TCTGACCATG ACTCCGCGGC CCCGACGTCC TTCTCGGCGC CGCCCCTGGC 9240

ATCGCGACGG GCGCAGCACT CGTGGCCCCA TGGAAAGGGG GGAGGAGGGG GCGGGGGGAC 9300

AGCCTGGGGT CCTTGGGGTT CGGGGGTCCT TGGGTTCCCG TGGAGGAACT CCCCGGACGT 9360 CTGGGTCCCC ACGGATGTAG TCGCGGACGG GCCCGAGGTT CCGCCGAGCG CCACGACGGC 9420

GGTTCGGCCA TCCCCGCCGG CTGCGACGTT TGAGATCGCG ACGAAGGCGC CGGTGGACGT 9480

AGCGCCCTCG AGGTCACGCA AATGACCGCG CGCCACGTCT CCGTCGATTA TCATACTGCA 9540

GTTGGAGCCG CATTGAACAA AGCTGCTGTC GCTAATGCGG TAGGCCGCGG GGCCGGGGGG 9600

ATCGCTGGAA AGCACCATCA CGCCGCTGAC TTTCCTGCAA AACACGTGGT CGCCGCCAGG 9660 GGGGGCGACC TCGGGCTCCC GGGGTTCCTG TCGTTCGGAC GGAGACCGCG CTCCGGCGAG 9720

GGCGGATGCG GCAGGGCGGT TGGCCATTGG AACCAAGGTG ACGGTGGCTC GGACGCGATG 9780

AACGGAAACA GCGGCGGGCC CGTGGGAGGC GGGGTGGGCG GTACGACCGA AAGGACGCAC 9840

CGGCCGACGA ATCACCCGGG CAGTCGCCAA CAATCTGTCG ACAGGACAGC ACCGGCCGAC 9900

AGGAACGCAA CAGGAATCGG TGGGCGAAAA CGTGAGGGCT CGCAGGAGAG TGGCGACCGT 9960 CAAGTCCCCG AAGCACCCAC CTGTTGTGGT AACCCAAACC GCCCGCGTTG GCTTTTATCC 10020

CCGGCACACA GGGGTGGGGT GCGATCGTGT GCTGAGTCAA TCTAAGGAGG ATATGCCTAT 10080

CTCCTGAGTC AGGGGGGTGT AACGTGTCCA TGAATCCCAT TTGCATGTCG GTTTCCGCCA 10140

TTTCAGAGAC ACACGCCAAA CACACCACGT CACGGATTTA ACCTGGCTTT ATTGAGACGG 10200

ACGCACGGGG CCGCGCACGG CCAAGACGGC GAGGGCGGAG TTGGTGTGTA GGAGGGGGGG 10260 GGGGGAAAGT GGGAGGGGAA GGTCGCTCGG GTTGGGCGGC CGTCGTCAAT AGACGATCAC 10320

GCGCAGGCCC GCCACCCGCC GGGGCGCCAC ACCACGCCCT CCAGGATGAC AACCGGAACG 10380

CCGACCGCCC CAAACCGCTC GGTGCGGTGC AGACAGCGGG GGCTGTTGTC TGGCATGACA 10440

CCCAGCTCTG CGAAGGCGGC GTATGTGCAG GTGCGTGCGG TAGGGCGCCC CCGCAGATCC 10500

GGCTGCCAGC GGTACAGCCT GTCGACAAAC TGGGGGTTCG TGACTTGGCT CGCCGAGCAC 10560 CGCGGGGATT GCGAGCTCGC GGCCAGGACG GCGAGCGGAA AGTCAACGTT TCGGTTCGGG 10620

GGAAGGGGCG TCATGTCCTC GGCCCCGTGA ATCGTGTTGG TTATCCGGAG GCGCCCGAAC 10680

AGCCGCTCGA GGGCCGCCTC CAGTCCGCGC GGGGGGAGCT GGCTCTTGAC CACGTACACG 10740

CAACAGAGCT CCTGGTCCCG GCACTGTCGG TAGGTGAAAA CCAAGTACAG GAACGCCGCC 10800 CCAGGGCCCC CCAGGCACAG CTCGGCGTCC AGGTCCACAA AGGCGCAGGC CGGGATGGTA 10860

ACGGCCGAAC AGGGCCTGCC CGGGTGGCCG GTGTGTGTGG CCTCCTGGGG TCCGCTGCAG 10920

ACGGCGGTGA CGCTAGCCAG CTCGTCCTGT GTGACCACGA CACTAGCCCC CCGAAAAACC 10980

GCATGACCTC GTGGGGAAAC ACGTGCGTGT GGACCATGGC GCGCAGGCAT TCGGAAAACC 11040 GGTCCAGCCG CGCCCCGGCC CGCGTCCCGC CGTAGTTGGT CGTGATGTGG GCCCGGACCG 11100

CCTCGGCGGC GTCGCGCGCA TCGTAGGCGG CGGCGCACGC GGCCACCAGA AAGTTAAACG 11160

ACACAAGGCC CGCGCGCGCG CAGCCGCTCT CGGCCCGCCC GGACCCCAGG GCGGAGGCCT 11220

CCAGGAGCTG GCCCCAGGCC TCGGCCAGTC GCTCGGTCTG CCGGCCGGGC GGAGCCCGAT 11280

GGCGGGCCAG GTGGGGGAGG TCGGTGGGGT GCCGCAGGGC CAAAAGGAGC GCCCCGGCCC 11340 GCTCCGCGTT TGGTTGGCAG AGATCCGTCA GGGTTACCTG GCGGGTCAGG TGATAGCGGG 11400

GGGCGCCGGG GACGGTCAGC CCTCCCGCGC GCCGGGCTCC CCTGAGGATC TTGTCCACGG 11460

CCTGCTCGGT ATCGTCTCGG GTAGCGCGCG TTCCCGGAGA CGACTCCGCG GGGTCGATCC 11520

CCAGCAGCCA CATCGTACTG GCCGTCCTCC TGGGGGCCCT GTCCCCCAAA AGCACCGGGC 11580

CGTCGCGGCG AGCGATGGGC GGGCGCAGGA CGCGCCGGAG CGGGGCGTGG CCCGCGAGCT 11640 CGCGCGGGCT GGTGGTGGTT TCCACGGCAC TCTCGGCCCA CGCCATCGGG GCTGTCGGGA 11700

GTGGCTTGGT TTTCATGGTT TTCCCGCCGA TCGCCAACGG GCGAGTTGTG GGGGGGGGGG 11760

TGGTGGAGGT GGGCCACCCC CCNGGCCGCC CGTANCCCTC CCCCCCCCTT CTGCCCTCCC 11820

CCCCCCCTCC TCGTGTCCTC TACCCATCTC TCTTCCCATT CCCCTCCCCC CTCTCCCTCC 11880

GTCCCTCTGC CCCTCCCTCC CTCCTCCCCG TTTCCTCTCA TTCCCTCCTT ATTCTCCCAC 11940 TATTCGTCTC TTGGCCTCTC GCTTATCCCC ATATCTCCCC TCCTGTGGTC CTATTATTCT 12000

CATCCTATCT CCTCTCCTTC TTACCATGAC AATTCTCTCC TCATCTCTCC TCTCCTTACT 12060

CCCCTCTCTC TCTCTGTCCA TGCTCTCCCC TCGTCTATCT ACCTCCACAT CTCCATTCTC 12120

TCCTCGTACT CTCTACTCCT CCCTATCATG TCATGCGTGC CCTCGCGTAC TCTTCTCTCC 12180

CCTATCTTTC CACTTCTCCC CCCCGCTCTA CTCTTCCTCT CATGCGTCGC TCTATCTTCT 12240 CTCTCCTCCT TCCGTCTATC TCTCTCCTCC CCTCTTTTCT TCACCCCTCG GTGACCCCCT 12300

CCTTGTTTAC ATCACTTTTG AAACTCCAGC TCTTGCTCTC CCCCACTGCT CCTCCTCCCC 12360

TGACCCCCCC CCCTCTCCCT TTCTCTCGTA TCTCAGTCCT CCTCTCTCCC CCTCTTTTTT 12420

CCCTCCTCTT CGTTCTCCTC CCTTCTTTTC GATCCCGCTC CTCTGTCTCC TCCTCCTTCT 12480

CTTCTCTT 12489

(2) INFORMATION FOR SEQ ID NO: 18:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 335 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 18:

Val Cys Pro Pro Pro Pro Thr Asn Met Ala Val Val Cys Gly Ser Gly 1 5 10 15

Leu Arg Leu Arg Pro Phe His Pro Pro Ser Pro Ser Phe Phe Val Leu

20 25 30

Arg Ala Leu Ile Arg Ala Gly Pro Gly Pro Phe Ala Asp Arg Ala Pro 35 40 45

Ser Gly Pro Gly Cys Gly Met Cys Arg Gly Asp Ser Pro Gly Val Ala

50 55 60

Gly Gly Ser Gly Glu His Cys Leu Gly Gly Asp Asp Gly Asp Asp Gly 65 70 75 80 Arg Pro Arg Leu Ala Cys Val Gly Ala Ile Arg Phe Ala His Leu Trp

85 90 95

Leu Gin Ala Thr Thr Leu Gly Phe Val Gly Ser Val Val Leu Ser Arg

100 105 110

Gly Pro Tyr Ala Asp Ala Met Ser Gly Ala Phe Val Ile Gly Ser Thr 115 120 125

Gly Leu Gly Phe Leu Arg Ala Pro Pro Ala Phe Ala Arg Pro Pro Thr

130 135 140

Arg Val Cys Ala Trp Leu Arg Leu Val Gly Gly Gly Ala Ala Val Trp 145 150 155 160 Ser Leu Gly Glu Ala Gly Ala Pro Pro Gly Val Pro Gly Pro Ala Thr

165 170 175

Gin Cys Leu Ala Leu Gly Ala Ala Tyr Ala Ala Leu Leu Val Leu Ala

180 185 190

Asp Asp Val His Pro Leu Phe Leu Leu Ala Pro Arg Pro Leu Phe Val 195 200 205

Gly Thr Leu Gly Val Val Val Gly Gly Leu Thr Ile Gly Gly Ser Ala

210 215 220

Arg Tyr Trp Trp Ile Asp Pro Arg Ala Ala Ala Ala Leu Thr Ala Ala 225 230 235 240 Val Val Ala Gly Leu Gly Thr Thr Ala Ala Gly Asp Ser Phe Ser Lys

245 250 255

Ala Cys Pro Arg His Arg Arg Phe Cys Val Val Ser Ala Val Glu Ser

260 265 270

Pro Pro Pro Arg Tyr Ala Pro Glu Asp Ala Glu Arg Pro Thr Asp His 275 280 285

Gly Pro Leu Leu Pro Ser Thr His His Gin Arg Ser Pro Arg Val Cys

290 295 300

Gly Asp Gly Ala Ala Arg Pro Glu Asn Ile Trp Val Pro Val Val Thr 305 310 315 320 Phe Ala Gly Ala Leu Ala Ala Cys Ala Arg Trp Trp Glu Arg Ser

325 330 335

(2) INFORMATION FOR SEQ ID NO: 19: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 466 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 19:

Met Ala His Leu Pro Gly Gly Ala Ala Ala Ala Pro Leu Ser Glu Asp

1 5 10 15

Ala Ile Pro Ser Pro Arg Glu Arg Thr Glu Asp Trp Pro Pro Cys Gin 20 25 30

Ile Val Leu Gin Gly Ala Glu Leu Asn Gly Ile Leu Gin Ala Phe Ala

35 40 45

Pro Leu Arg Thr Ser Leu Leu Asp Ser Leu Leu Val Val Gly Asp Arg 50 55 60 Gly Ile Leu Val His Asn Ala Ile Phe Gly Glu Gin Val Phe Leu Pro 65 70 75 80

Leu Asp His Ser Gin Phe Ser Arg Tyr Arg Trp Gly Gly Pro Thr Ala

85 90 95

Ala Phe Leu Ser Leu Val Asp Gin Lys Arg Ser Leu Leu Ser Val Phe 100 105 110

Arg Ala Asn Gin Tyr Pro Asp Leu Arg Arg Val Glu Leu Thr Val Thr

115 120 125

Gly Gin Ala Pro Phe Arg Thr Leu Val Gin Arg Ile Trp Thr Thr Ala

130 135 140 Ser Asp Gly Glu Ala Val Glu Leu Ala Ser Glu Thr Leu Met Lys Arg

145 150 155 160

Glu Leu Thr Ser Phe Ala Val Leu Leu Pro Gin Gly Asp Pro Asp Val

165 170 175

Gin Leu Arg Leu Thr Lys Pro Gin Leu Thr Lys Val Val Asn Ala Val 180 185 190

Gly Asp Glu Thr Ala Lys Pro Thr Thr Phe Glu Leu Gly Pro Asn Gly

195 200 205

Lys Phe Ser Val Phe Asn Ala Arg Thr Cys Val Thr Phe Ala Ala Arg 210 215 220 Glu Glu Gly Ala Ser Ser Ser Thr Ser Ala Gin Val Gin Ile Leu Thr 225 230 235 240

Ser Ala Leu Lys Lys Ala Gly Gin Ala Ala Ala Asn Ala Lys Thr Val 245 250 255 Tyr Gly Glu Asn Thr Thr Phe Ser Val Val Val Asp Asp Cys Ser Met

260 265 270

Arg Ala Val Leu Arg Arg Leu Gin Val Gly Gly Gly Thr Leu Asn Phe 275 280 285 Phe Leu Thr Ala Asp Val Pro Ser Val Cys Val Thr Ala Thr Gly Pro 290 295 300

Asn Ala Val Ser Ala Val Phe Leu Leu Lys Pro Gin Arg Val Cys Leu 305 310 315 320

Asn Trp Leu Gly Arg Thr Pro Gly Ser Ser Thr Gly Ser Leu Ala Ser 325 330 335

Gin Asp Ser Arg Ala Gly Pro Thr Asp Ser Gin Asp Phe Ser Ser Glu

340 345 350

Pro Asp Ala Gly Asp Arg Gly Ala Pro Glu Glu Glu Gly Leu Glu Gly 355 360 365 Gin Ala Arg Val Pro Pro Ala Phe Pro Glu Pro Pro Gly Thr Lys Arg 370 375 380

Arg His Ala Gly Ala Glu Val Val Pro Ala Asp Asp Ala Thr Lys Arg 385 390 395 400

Pro Lys Thr Gly Val Pro Ala Ala Pro Thr Arg Ala Glu Ser Pro Pro 405 410 415

Leu Ser Ala Arg Tyr Gly Pro Glu Ala Ala Glu Gly Gly Gly Asp Gly

420 425 430

Gly Arg Tyr Ala Trp Tyr Phe Arg Asp Leu Gin Thr Gly Asp Asp Ser 435 440 445 Pro Leu Ser Ala Phe Arg Gly Pro Gin Arg Pro Pro Tyr Gly Phe Gly 450 455 460

Leu Pro 465

(2) INFORMATION FOR SEQ ID NO: 20:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 218 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 20:

Met Gly Leu Phe Gly Met Met Lys Phe Ala Gin Thr His His Leu Val 1 5 10 15 Lys Arg Arg Gly Leu Arg Ala Pro Glu Gly Tyr Phe Thr Pro Ile Ala

20 25 30

Val Asp Leu Trp Asn Val Met Tyr Thr Leu Val Val Lys Tyr Gin Arg 35 40 45 Arg Tyr Pro Ser Tyr Asp Arg Glu Ala Ile Thr Leu His Cys Leu Cys 50 55 60

Ser Met Leu Arg Val Phe Thr Gin Lys Ser Leu Phe Pro Ile Phe Val 65 70 75 80

Thr Asp Arg Gly Val Glu Cys Thr Glu Pro Val Val Phe Gly Ala Lys 85 90 95

Ala Ile Leu Ala Arg Thr Thr Ala Gin Cys Arg Thr Asp Glu Glu Ala

100 105 110

Ser Asp Val Asp Asp Pro Pro Phe Pro His His Arg Leu Gin Ala Gin 115 120 125 Phe Pro Pro Phe Gin His Ala Pro Pro Arg Ala Arg Leu Arg Pro Gly 130 135 140

Gly Pro Gly Glu Arg Gly Pro Pro Ala Gin Ala Arg Arg Pro Pro Gly 145 150 155 160

Ala Arg Pro Arg Ser Arg Pro Cys Ala Trp Leu Thr Cys Ser Val Ser 165 170 175

Ala Phe Cys Gly Arg Trp Gly Thr Pro Thr Ser Thr Arg Val Ser Trp

180 185 190

Arg Pro Thr Thr Pro Ala Arg Thr Ser Ile Ile Pro Thr Arg Ser Arg 195 200 205 Thr Cys Ile Pro Arg Ile Pro Ile Ser Cys 210 215

(2) INFORMATION FOR SEQ ID NO: 21:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 282 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 21:

Val His Thr Thr Asp Thr Asp Leu Leu Leu Met Gly Cys Asp Ile Val 1 5 10 15

Leu Asp Ile Ser Thr Gly Tyr Ile Pro Thr Ile His Cys Arg Asp Leu 20 25 30 Leu Gin Tyr Phe Lys Met Ser Tyr Pro Gin Phe Leu Ala Leu Phe Val

35 40 45

Arg Cys His Thr Asp Leu His Pro Asn Asn Thr Tyr Ala Ser Val Glu 50 55 60 Asp Val Leu Arg Glu Cys His Trp Thr Ala Pro Ser Arg Ser Gin Ala 65 70 75 80

Arg Arg Gly Ala Arg Arg Glu Arg Ala Asn Ser Arg Ser Leu Glu Ser

85 90 95

Met Pro Thr Leu Thr Ala Ala Pro Val Gly Leu Glu Thr Arg Ile Ser 100 105 110

Trp Thr Glu Ile Leu Ala Gin Gin Ile Ala Gly Glu Asp Asp Tyr Glu

115 120 125

Glu Asp Pro Pro Leu Gin Pro Pro Asp Val Ala Gly Gly Pro Arg Asp

130 135 140 Gly Ala Arg Ser Ser Ser Ser Glu Ile Leu Thr Pro Pro Glu Leu Val

145 150 155 160

Gin Val Pro Asn Ala Gin Arg Val Ala Glu His Arg Gly Tyr Val Ala

165 170 175

Gly Arg Arg Arg His Val Ile His Asp Ala Pro Glu Ala Leu Asp Trp 180 185 190

Leu Pro Asp Pro Met Thr Ile Ala Glu Leu Val Glu His Arg Tyr Val

195 200 205

Lys Tyr Val Ile Ser Leu Ile Ser Pro Lys Glu Arg Gly Pro Trp Thr

210 215 220 Leu Leu Lys Arg Leu Pro Ile Tyr Gin Asp Leu Arg Asp Glu Asp Leu

225 230 235 240

Ala Arg Ser Ile Val Thr Arg His lie Thr Ala Pro Asp Ile Ala Asp

245 250 255

Arg Phe Leu Ala Gin Leu Trp Ala His Ala Pro Pro Pro Ala Phe Tyr 260 265 270

Lys Asp Val Leu Ala Lys Phe Trp Asp Glu 275 280

(2) INFORMATION FOR SEQ ID NO: 22:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 528 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22:

Met Arg Ala Gly Leu Val Phe Phe Val Gly Val Trp Val Val Ser Cys 1 5 10 15 Leu Ala Ala Ala Pro Arg Thr Ser Trp Lys Arg Val Thr Ser Gly Glu 20 25 30

Asp Val Val Leu Leu Pro Ala Pro Ala Gly Pro Glu Glu Arg Thr Arg

35 40 45

Ala His Lys Leu Leu Trp Ala Ala Glu Pro Leu Asp Ala Cys Gly Pro 50 55 60

Leu Arg Pro Ser Trp Val Trp Pro Pro Arg Arg Val Leu Glu Thr Val 65 70 75 80

Val Asp Ala Ala Cys Met Arg Ala Pro Glu Pro Leu Ala Ile Ala Tyr 85 90 95 Ser Pro Pro Phe Pro Ala Gly Asp Glu Gly Ser Glu Leu Ala Trp Arg 100 105 110

Asp Arg Val Ala Val Val Asn Glu Ser Leu Val Ile Tyr Gly Ala Leu

115 120 125

Glu Thr Asp Ser Gly Thr Leu Ser Val Val Gly Leu Ser Asp Glu Ala 130 135 140

Arg Gin Val Ala Ser Val Val Leu Val Val Glu Pro Ala Pro Val Pro

145 150 155 160

Thr Pro Thr Pro Asp Asp Tyr Asp Glu Glu Asp Asp Ala Gly Val Ser

165 170 175 Thr Pro Val Ser Val Pro Pro Pro Thr Pro Pro Arg Gly Pro Pro Val

180 185 190

Ala Pro Pro Thr His Pro Arg Val Ile Pro Glu Val Ser His Val Arg

195 200 205

Gly Val Thr Val His Met Pro Glu Ala Ile Leu Phe Ala Pro Gly Glu 210 215 220

Thr Phe Gly Thr Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gly

225 230 235 240

Pro Tyr Ala Met Asp Val Val Trp Met Arg Phe Asp Val Pro Ser Ser

245 250 255 Cys Ala Glu Met Arg Ile Tyr Glu Ala Cys Leu Tyr His Pro Gin Leu

260 265 270

Pro Glu Cys Leu Ser Pro Ala Asp Ala Pro Cys Ala Val Ser Ser Trp

275 280 285

Ala Tyr Arg Leu Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Thr 290 295 300

Pro Pro Pro Arg Cys Phe Ala Glu Ala Arg Met Glu Pro Val Pro Gly 305 310 315 320

Leu Ala Trp Leu Ala Ser Thr Val Asn Leu Glu Phe Gin His Asp Gin 325 330 335

His Ala Gly Leu Cys Val Val Tyr Val Asp Asp His Ile His Ala Trp

340 345 350

Gly His Met Thr Ile Ser Thr Ala Ala Gin Tyr Arg Asn Ala Val Val 355 360 365

Glu Gin His Leu Pro Gin Arg Gin Pro Glu Pro Val Glu Pro Trp His

370 375 380

Val Arg Ala Pro Pro Pro Ala Pro Ser Arg Pro Leu Arg Leu Gly Ala 385 390 395 400 Val Leu Gly Ala Ala Leu Leu Leu Ala Ala Leu Gly Leu Ser Ala Trp

405 410 415

Ala Cys Met Thr Cys Trp Arg Arg Arg Ser Trp Arg Ala Val Lys Ser

420 425 430

Arg Ala Ser Ala Thr Gly Pro Thr Tyr Ile Arg Val Ala Asp Ser Glu 435 440 445

Leu Tyr Ala Asp Trp Ser Ser Asp Ser Glu Gly Glu Arg Asp Gly Ser

450 455 460

Leu Trp Gin Asp Pro Pro Glu Arg Pro Asp Ser Pro Ser Thr Asn Gly 465 470 475 480 Ser Gly Phe Glu Ile Leu Ser Pro Thr Ala Pro Ser Val Tyr Pro His

485 490 495

Ser Glu Gly Arg Lys Ser Arg Arg Pro Leu Thr Thr Phe Gly Ser Gly

500 505 510

Ser Pro Gly Arg Arg His Ser Gin Ala Ser Tyr Ser Ser Val Leu Trp 515 520 525

(2) INFORMATION FOR SEQ ID NO: 23:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1160 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:23:

Val Ile Arg Arg Pro Val Arg Pro Phe Gly Arg Thr Ala His Pro Ala 1 5 10 15

Ser His Gly Pro Ala Ala Val Ser Val His Arg Val Arg Ala Thr Val

20 25 30

Thr Leu Val Pro Met Ala Asn Arg Pro Ala Ala Ser Ala Gly Ala Arg 35 40 45

Ser Pro Ser Gin Glu Pro Arg Glu Pro Glu Val Ala Pro Pro Gly Gly

50 55 60

Asp His Val Phe Cys Arg Lys Val Ser Gly Val Met Val Leu Ser Ser 65 70 75 80

Asp Pro Pro Gly Pro Ala Ala Tyr Arg Ile Ser Asp Ser Ser Phe Val

85 90 95

Gin Cys Gly Ser Asn Cys Ser Met Ile Ile Asp Gly Asp Val Arg His 100 105 110 Leu Arg Asp Leu Glu Gly Ala Thr Ser Thr Gly Ala Phe Val Ala Ile 115 120 125

Ser Asn Val Ala Ala Gly Gly Asp Gly Arg Thr Ala Val Val Gly Gly

130 135 140

Thr Ser Gly Pro Ser Ala Thr Thr Ser Val Gly Thr Gin Thr Ser Gly 145 150 155 160

Glu Phe Leu His Gly Asn Pro Arg Thr Pro Glu Pro Gin Gly Pro Gin

165 170 175

Ala Val Pro Pro Pro Pro Pro Pro Pro Phe Pro Trp Gly His Glu Cys 180 185 190 Cys Ala Arg Arg Asp Arg Gly Ala Glu Lys Asp Val Gly Ala Ala Glu 195 200 205

Ser Trp Ser Asp Gly Pro Ser Ser Asp Ser Glu Thr Glu Asp Ser Asp

210 215 220

Ser Ser Asp Glu Asp Thr Gly Ser Gly Ser Glu Thr Leu Ser Arg Ser 225 230 235 240

Ser Ser Ile Trp Ala Ala Gly Ala Thr Asp Asp Asp Asp Ser Asp Ser

245 250 255

Asp Ser Arg Ser Asp Asp Ser Val Gin Pro Asp Val Val Val Arg Arg 260 265 270 Arg Trp Ser Asp Gly Pro Ala Pro Val Ala Phe Pro Lys Pro Arg Arg 275 280 285

Pro Gly Asp Ser Pro Gly Asn Pro Gly Leu Gly Ala Gly Thr Gly Pro

290 295 300

Gly Ser Ala Thr Asp Pro Arg Ala Ser Ala Asp Ser Asp Ser Ala Ala 305 310 315 320

His Ala Ala Ala Pro Gin Ala Glu Val Ala Pro Val Leu Asp Ser Gin

325 330 335

Pro Thr Val Gly Thr Asp Pro Gly Tyr Pro Val Pro Leu Glu Leu Thr 340 345 350 Pro Glu Asn Ala Glu Ala Val Ala Arg Phe Leu Gly Asp Ala Val Asp 355 360 365

Arg Glu Pro Ala Leu Met Leu Glu Tyr Phe Cys Arg Cys Ala Arg Glu 370 375 380 Glu Ser Lys Arg Val Pro Pro Arg Thr Phe Gly Ser Ala Pro Arg Leu

385 390 395 400

Thr Glu Asp Asp Phe Gly Leu Leu Asn Tyr Ala Glu Met Arg Arg Leu

405 410 415 Cys Leu Asp Leu Pro Pro Val Pro Pro Asn Ala Tyr Thr Pro Tyr His

420 425 430

Leu Arg Glu Tyr Ala Thr Arg Leu Val Asn Gly Phe Lys Pro Leu Val

435 440 445

Arg Arg Ser Ala Arg Leu Tyr Arg Ile Leu Gly Ile Leu Val His Leu 450 455 460

Arg Ile Arg Thr Arg Glu Ala Ser Phe Glu Glu Trp Met Arg Ser Lys

465 470 475 480

Glu Val Asp Leu Asp Phe Gly Leu Thr Glu Arg Leu Arg Glu His Glu

485 490 495 Ala Gin Leu Met Ile Leu Ala Gin Ala Leu Asn Pro Tyr Asp Cys Leu

500 505 510

Ile His Ser Thr Pro Asn Thr Leu Val Glu Arg Gly Leu Gin Ser Ala

515 520 525

Leu Lys Tyr Glu Glu Phe Tyr Leu Lys Arg Phe Gly Gly His Tyr Met 530 535 540

Glu Ser Val Phe Gin Met Tyr Thr Arg Ile Ala Gly Phe Leu Ala Cys

545 550 555 560

Arg Ala Thr Arg Gly Met Arg His Ile Ala Leu Gly Arg Gin Gly Ser

565 570 575 Trp Trp Glu Met Phe Lys Phe Phe Phe His Arg Leu Tyr Asp His Gin

580 585 590

Ile Val Pro Ser Thr Pro Ala Met Leu Asn Leu Gly Thr Arg Asn Tyr

595 600 605

Tyr Thr Ser Ser Cys Tyr Leu Val Asn Pro Gin Ala Thr Thr Asn Gin 610 615 620

Ala Thr Leu Arg Ala Ile Thr Gly Asn Val Ser Ala Ile Leu Ala Arg

625 630 635 640

Asn Gly Gly Ile Gly Leu Cys Met Gin Ala Phe Asn Asp Asp Gly Thr

645 650 655 Ala Ser Ile Met Pro Ala Leu Lys Val Leu Asp Ser Leu Val Ala Ala

660 665 670

His Asn Lys Gin Ser Trp Thr Gly Ala Cys Val Tyr Leu Glu Pro Trp

675 680 685

His Ser Asp Val Arg Ala Val Leu Arg Met Lys Gly Val Leu Ala Gly 690 695 700

Glu Glu Ala Gin Arg Cys Asp Asn Ile Phe Ser Ala Leu Trp Met Pro 705 710 715 720

Asp Leu Phe Phe Lys Arg Leu Ile Arg His Leu Asp Gly Glu Glu Asn 725 730 735

Val Thr Trp Ser Leu Phe Asp Arg Asp Thr Ser Met Ser Leu Ala Asp

740 745 750

Phe His Gly Glu Glu Phe Glu Lys Leu Tyr Glu His Leu Glu Ala Met 755 760 765

Gly Phe Gly Glu Thr Ile Pro Ile Gin Asp Leu Ala Tyr Ala Ile Val

770 775 780

Arg Ser Ala Ala Thr Thr Gly Ser Pro Phe Ile Met Phe Lys Asp Ala 785 790 795 800 Val Asn Arg His Tyr Ile Tyr Asn Thr Gin Gly Ala Ala Ile Ala Gly

805 810 815

Ser Asn Leu Cys Thr Glu Ile Val His Pro Ser Ser Lys Arg Ser Ser

820 825 830

Gly Val Cys Asn Leu Gly Ser Val Asn Leu Ala Arg Cys Val Ser Arg 835 840 845

Arg Thr Phe Asp Phe Gly Met Leu Arg Asp Ala Val Gin Ala Cys Val

850 855 860

Leu Met Val Asn Ile Met Ile Asp Ser Thr Leu Gin Pro Thr Pro Gin 865 870 875 880 Cys Arg His Asp Asn Leu Arg Ser Met Gly Ile Gly Met Gin Gly Leu

885 890 895

His Thr Ala Cys Leu Lys Met Gly Leu Asp Leu Glu Ser Ala Glu Phe

900 905 910

Arg Asp Leu Asn Thr His Ile Ala Glu Val Met Leu Leu Ala Ala Met 915 920 925

Lys Thr Ser Asn Ala Leu Cys Val Arg Gly Ala Arg Pro Phe Ser His

930 935 940

Phe Lys Arg Ser Met Tyr Arg Ala Gly Arg Phe His Trp Glu Arg Phe 945 950 955 960 Ser Asn Asp Arg Tyr Glu Gly Glu Trp Glu Met Leu Arg Gin Ser Met

965 970 975

Met Lys His Gly Leu Arg Asn Ser Gin Phe Ile Ala Leu Met Pro Thr

980 985 990

Ala Ala Ser Ala Gin Ile Ser Asp Val Ser Glu Gly Phe Ala Pro Leu 995 1000 1005

Phe Thr Asn Leu Phe Ser Lys Val Thr Arg Asp Gly Glu Thr Leu Arg

1010 1015 1020

Pro Asn Thr Leu Leu Leu Lys Glu Leu Glu Arg Thr Phe Gly Gly Lys 1025 1030 1035 104 Arg Leu Leu Asp Ala Met Asp Gly Leu Glu Ala Lys Gin Trp Ser Val

1045 1050 1055

Ala Gin Ala Leu Pro Cys Leu Asp Pro Ala His Pro Leu Arg Arg Phe 1060 1065 1070 Lys Thr Ala Phe Asp Tyr Asp Gin Glu Leu Leu Ile Asp Leu Cys Ala

1075 1080 1085

Asp Arg Ala Pro Tyr Val Asp His Ser Gin Ser Met Thr Leu Tyr Val

1090 1095 1100

Thr Glu Lys Ala Asp Gly Thr Leu Pro Ala Ser Thr Leu Val Arg Leu 1105 1110 1115 112

Leu Val His Ala Tyr Lys Arg Gly Leu Lys Thr Gly Met Tyr Tyr Cys

1125 1130 1135

Lys Val Arg Lys Ala Thr Asn Ser Gly Val Phe Ala Gly Asp Asp Asn

1140 1145 1150

Ile Val Cys Thr Ser Cys Ala Leu 1155 1160

(2) INFORMATION FOR SEQ ID NO: 24:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 269 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 24:

Val Arg Arg Arg Leu Arg Cys Ala Arg Arg Arg Arg Gly Gly Pro Gly

1 5 10 15

Pro His His Asp Gin Leu Arg Arg Asp Ala Gly Arg Gly Ala Ala Gly 20 25 30 Pro Val Phe Arg Met Pro Ala Arg His Gly Pro His Ala Arg Val Ser 35 40 45

Pro Arg Gly His Ala Val Phe Arg Gly Ala Ser Val Val Val Thr Gin

50 55 60

Asp Glu Leu Ala Ser Val Thr Ala Val Cys Ser Gly Pro Gin Glu Ala 65 70 75 80

Thr His Thr Gly His Pro Gly Arg Pro Cys Ser Ala Val Thr Ile Pro

85 90 95

Ala Cys Ala Phe Val Asp Leu Asp Ala Glu Leu Cys Leu Gly Gly Pro 100 105 110 Gly Ala Ala Phe Leu Tyr Leu Val Phe Tyr Gin Cys Arg Asp Gin Glu 115 120 125

Leu Cys Cys Val Tyr Val Val Lys Ser Gin Leu Pro Pro Arg Gly Leu 130 135 140 Glu Ala Ala Leu Glu Arg Leu Phe Gly Arg Leu Arg Ile Thr Asn Thr

145 150 155 160

Ile His Gly Ala Glu Asp Met Thr Pro Leu Pro Pro Asn Arg Asn Val

165 170 175 Asp Phe Pro Leu Ala Val Leu Ala Ala Ser Ser Gin Ser Pro Arg Cys

180 185 190

Ser Ala Ser Gin Val Thr Asn Pro Gin Phe Val Asp Arg Leu Tyr Arg

195 200 205

Trp Gin Pro Asp Leu Arg Gly Arg Pro Thr Ala Arg Thr Cys Thr Tyr 210 215 220

Ala Ala Phe Ala Glu Leu Gly Val Met Pro Asp Asn Ser Pro Arg Cys 225 230 235 240

Leu His Arg Thr Glu Arg Phe Gly Ala Val Gly Val Pro Val Val Ile 245 250 255 Gly Val Val Trp Arg Pro Gly Gly Trp Arg Ala Cys Ala 260 265

(2) INFORMATION FOR SEQ ID NO: 25:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 347 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 25:

Met Lys Thr Lys Pro Leu Pro Thr Ala Pro Met Ala Trp Ala Glu Ser 1 5 10 15

Ala Val Glu Thr Thr Thr Ser Pro Arg Glu Leu Ala Gly His Ala Pro

20 25 30

Leu Arg Arg Val Leu Arg Pro Pro Ile Ala Arg Arg Asp Gly Pro Val 35 40 45

Leu Leu Gly Asp Arg Ala Pro Arg Arg Thr Ala Ser Thr Met Trp Leu

50 55 60

Leu Gly Ile Asp Pro Ala Glu Ser Ser Pro Gly Thr Arg Ala Thr Arg 65 70 75 80 Asp Asp Thr Glu Gin Ala Val Asp Lys Ile Leu Arg Gly Ala Arg Arg

85 90 95

Ala Gly Gly Leu Thr Val Pro Gly Ala Pro Arg Tyr His Leu Thr Arg 100 105 110 Gin Val Thr Leu Thr Asp Leu Cys Gin Pro Asn Ala Glu Arg Ala Gly

115 120 125

Ala Leu Leu Leu Ala Leu Arg His Pro Thr Asp Leu Pro His Leu Ala

130 135 140 Arg His Arg Ala Pro Pro Gly Arg Gin Thr Glu Arg Leu Ala Glu Ala

145 150 155 160

Trp Gly Gin Leu Leu Glu Ala Ser Ala Leu Gly Ser Gly Arg Ala Glu

165 170 175

Ser Gly Cys Ala Arg Ala Gly Leu Val Ser Phe Asn Phe Leu Val Ala 180 185 190

Ala Cys Ala Ala Ala Tyr Asp Ala Arg Asp Ala Ala Glu Ala Val Arg

195 200 205

Ala His Ile Thr Thr Asn Tyr Gly Gly Thr Arg Ala Gly Ala Arg Leu

210 215 220 Asp Arg Phe Ser Glu Cys Leu Arg Ala Met Val His Thr His Val Phe

225 230 235 240

Phe Val Met Arg Phe Phe Gly Gly Leu Val Ser Trp Ser His Arg Thr

245 . 250 255

Ser Trp Leu Asp Pro Ser Ala Ala Asp Pro Arg Arg Pro His Thr Pro 260 265 270

Ala Thr Arg Ala Gly Pro Val Arg Pro Leu Pro Ser Arg Pro Ala Pro

275 280 285

Leu Trp Thr Trp Thr Pro Ser Cys Ala Trp Gly Ala Leu Gly Arg Arg

290 295 300 Ser Cys Thr Trp Phe Ser Pro Thr Asp Ser Ala Gly Thr Arg Ser Ser

305 310 315 320

Val Ala Cys Thr Trp Ser Arg Ala Ser Ser Pro Arg Ala Asp Trp Arg

325 330 335

Arg Pro Ser Ser Gly Cys Ser Gly Ala Ser Gly 340 345

(2) INFORMATION FOR SEQ ID NO: 26:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12701 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 26:

GTAGAAGTAA GGAGAGAGTG AGAGTATAGA GAAATAGATG AGAGAGAGAA GGTNAGATAA 60 ATAAGAGGGA CAGAGAGTAG GGAGTAGGGT TAGAGAGGAT GAGGGAGAAA GATGAGAGAA 120

GAGGGGAAGA TATATAGATG AGAGAAGGGA AGGAATGAGA GAGGGAAGAA TGATGGAAGG 180

GAAGGAGNAG AGAAGAGTAG TAGAGGGAAA AAAGAGAAGG AGAAAAGNAA GGAAAGAAAT 240

AGAAGAGNAG AGAAGGAAGA GAGAAAGAGA GAAGGAAGGA GGGGAAAGAA GAAANAAGAA 300 GGGAAGAAGG AAAGGAAGAG NAGAAGAAGG AAGAGAAGAG AAAGAAGAAG NAGAGGGGGA 360

AGAAAAGAGA GGAAGAGGGG AAGGAGGAAA GGAGGGAGAA GAAAAAANAA AAAACCACAC 420

GGCGGCCGAA ACGTCGGGGG AACCGGTAGA AGTCCTGCAG GTCGGACGAA CCAACGGACA 480

CCTCCGCAAA GCGCGCGCGC GCCTCCCCCG CGGCGTCGCG ACAGACCAGA TACAGCAGGG 540

CGTGGAGGCA GTCGCGCGTG CGCGGGGGCA GCCATACCGC GTATAGGGTA ATGGCGCTGA 600 CGCTCTCCTC CACCCAAACG ATGCCGGGGG CTTCCATGCC ACGACGCCCG GGGGTTGCCG 660

TGTATCGAAC GAGCGCGGCC CCAGACTTAT AGGGTGCTAA AGTTCACCGC CCCCTGCATC 720

ATGGGCCAGG CCTCGGTGGG AAGCTCCGAC AGAGCCGCCT CGAGAATGAT GTCAGTGTTG 780

GGCTGGGCGC CGGAGGCGTG CGTGCGCAAG CAGCGCCCCC ACGCGGGCGC GCGCAGCTTG 840

AAGCGCGCGC CCGCAAACTC CCGCTTATGG GCCATCAGCA GCGCGTACAG CTGTCTGTGC 900 GTCCGGCAGG CGCTGTGGTC GATGCGGTGG GCGTCCAGCA GCTCCACGAT GGCTCGCTTG 960

GTGAGGTTTT TAACGCGCCC CGCCCCGGGA AACGTCTGCG TGCTCTTGGC CAGCTGCACC 1020

CCGAACAGTT CGCCCCAGAT GATCTTGAAC AGCGACAGCG CGTGCTCCGT CTCGCTCACG 1080

GACCCGCGCG GGGGGCAGCC GCTCAGGGCG TCGGCCACGC GCTTAACCGC GTCCTCCGAC 1140

AGCAAGGGGC CGTCGGTCAC GTTACAGTGG CCCAGTTCGA ACACCAGCTG CATGTAGCGG 1200 TCGTAGTGGG GGTTCAGCAG CTCCAGCACG TCCTCGGGGC TAAAGGTTCG CCCCGACCCC 1260

CCGGCCATCG AGTCCCACTG CAGGCACGCG GCCATGGTGC TGCACAGACG GAACAGCTCC 1320

CAGACGGGGG CGACGTTTAG GGTGGGGTGT AGGGCCACAA GCTCCAGCTC TCCGGCGGCG 1380

TTGATCGTGG GGATGACGCC CGTGGCGTAG TGGTCGTAAA GCCGCCGGAA GATGGCGCTG 1440

CTATGGGCGG CCATGGGGAC GCGAAGACAG GCCTCCAGCA GCACCAGGTA GATGAACCGC 1500 GTGCGGCCGA CCAGGCTGTT GAGGCCGCGC ATGAGCGCGA CCACCTCGGC CGGCGCGACG 1560

TCCGGCCGGA GGTACTTTTC GACGAAAAGG CCCACCTCCT CCGTCTCGGC GGCCTGGGCC 1620

GACAGGGACG TGTCGGGGTC CTGGCAGCGC AGCTCCCGCA GATCCCGCTG GGCCCTCAGG 1680

GCATCAAAAT GTATCCCCCG CAAAAACAGA CAAAAGTTCC TCGGGGTCAG CGCGGCGTCG 1740

TGGCCCCAGA ACCGCACGTG CATGCAGTTG AGGGTCAGAA GCATGTGGAG GATGTTAAGA 1800 CTGTCCGCGA GGCACGCCAG CGTGCACCTC TCGAAGTAGT GCTTGTACCG GAATTTGCTG 1860

TAGATGCGCG ACCCCCGCGC CTGCGCCGCG TCGGCGTGCG ACGCGTCGCA GCGCCCTTTG 1920

AACCGGCGGC ACAACAGGTT CGTCACCTGG GAAAACTGTG CCGGCCACTG CCCGCTGGCG 1980

CTCACCACGT GGTTGAGCAG CATGGGCGTA AAGACGGGCT CCGAGCGCGC CCCGGACCCG 2040

TCCATGTAGA TCAGCAGCTC CCCCTTGCGG AGAGTCCGTA CCCGCCCCAG CGACTGGTAC 2100 ACGGACACCA TGTCCGGCCC GTAGTTCATG GGTTTCACGT AGGCGAACAT GCTGTCAAAG 2160

TGCGGCGGAT CGAAGCTAAG GCCCACCGTC ACGACCGTTG TGTAAATGAC CACCCGGTAC 2220

CGGCCCCATG TGGTCACTTC GCCGGGCGGG GTGAGCGAGT GGAGCAGCAG CACGCGGTCC 2280

GTAAACTGCC GGCAGAACCT GGCAACGACC TCCGCGAAGG AGACCGTCGA CAAGAAGATG 2340

CAGACGTTAT CTCCGCCGGC CAGGCGCGCC TCCACCTCCC CGAAGAAGGT GGCGTCCGGG 2400 GGGGCGTCCG GGGGGGGCGC CCCGCCCGCC GGCCCCGGCG GGCGCAGGGC CGCCTGCAGG 2460

ACCTCGGGCC CCAGGCGCGG GAGAAACAGA CAACGGCGCG CCGAAAATCC GGGCATGGCA 2520

TACTCCCCGA TGACCACGTG AACGTTCTTT TCGCCCCGGA GGCTGCACAG AAAGTCCACC 2580

AGCTGCGCGT TGGCGGTGGC GTCCATGGCG ATGATCCGCG GGCACGTGCG CAGCAGGCGC 2640 AGCATCAACG CGTCGACGCG GCCCAGCTGC TGCATCGTCG GCGAGTACAG TTGGCCCAAC 2700

GTCGACATGA CTTCGTCCAG GACGAGCACG TCGTAGTTGT TCAACAGGTT CGGGCCCACG 2760

CGATGAAGAC TTTCCACCTG CACGATGAGA CGGTGGAAGG GGCGGTCGTT CATGATGTAA 2820

TTGGTGGATG AGAAGTAGGT GACGAAGTCG GGCAACCCTG ACTCAGCGAA CCGCGTCGCC 2880 AGGGTCTGAG TAAAACTCCG ACGACAGGAG ACGACCAGCA CACTCGTGTC CGGAGAGTGG 2940

ATCGCTTCCC CCAACCAGCG GATCAGCGCG GTAGTTTTTC CCGAGCCCAT TGGCGCGCGG 3000

ACCACAGTTA CGCACCGGGC CGTCGGGGCG CTCGCGTCCG GGAAGGTGAC GGGTCCGTGT 3060

TGCTGCCGCT CGATCGTTGT TTTCGGGTGG ACCCGGGGAA CCCACTCGGC CAAATCCCCC 3120

CCGTAAAGCA TCCGCGCCAG CGATACACTC GACGTGTACT GCTCGCACTC GTCATCCCCG 3180 ATGGGACGCC GGGCCCCCAG GGGATCCCCC GAGGCCGCGC CGGGCGCCGA CGTCGCGCCC 3240

GGGGCGCGGG CGGCGTGGTG GGTCTGGTGT GTGCAGGTGG CGACGTTCAT CGTCTCGGCC 3300

ATCTGCGTCG TGGGGCTCCT GGTGCTGGCC TCTGTGTTCC GGGACAGGTT TCCCTGCCTT 3360

TACGCCCCCG CGACCTCTTA TGCGGAGGCG AACGCCACGG TCGAGGTGCG CGGGGGTGTA 3420

GCCGTCCCCC TCCGGTTGGA CACGCAGAGC CTGCTGGCCA CGTACGCAAT TACGTCTACG 3480 CTGTTGCTGG CGGCGGCCGT GTACGCCGCG GTGGGCGCGG TGACCTCGCG CTACGAGCGC 3540

GCGCTGGATG CGGCCCGTCG CCTGGCGGCG GCCCGTATGG CGATGCCACA CGCCACGCTA 3600

ATCGCCGGAA ACGTCTGCGC GTGGCTGTTG CAGATCACAG TCCTGCTGCT GGCCCACCGC 3660

ATCAGCCAGC TGGCCCACCT TATCTACGTC CTGCACTTTG CGTGCCTCGT GTATCTCGCG 3720

GCCCATTTTT GCACCAGGGG GGTCCTGAGC GGGACGTACC TGCGTCAGGT TCACGGCCTG 3780 ATTGACCCGG CGCCGACGCA CCATCGTATC GTCGGTCCGG TGCGGGCAGT AATGACAAAC 3840

GCCTTATTAC TGGGCACCCT CCTGTGCACG GCCGCCGCCG CGGTCTCGTT GAACACGATC 3900

GCCGCCCTCA ACTTCAACTT TTCCGCCCCG AGCATGCTCA TCTGCCTGAC GACGCTGTTC 3960

GCCCTGCTTG TCGTGTCGCT GTTGTTGGTG GTCGAGGGGG TGCTGTGTCA CTACGTGCGC 4020

GTGTTGGTGG GCCCCCACCT CGGGGCCATC GCCGCCACCG GCATCGTCGG CCTGGCCTGC 4080 GAGCACTACC ACACCGGTGG CTACTACGTG GTGGAGCAGC AGTGGCCGGG GGCCCAGACG 4140

GGAGTCCGCG TCGCCCTGGC GCTCGTCGCC GCCTTTGCCC TCGCCATGGC CGTGCTTCGG 4200

TGCACGCGCG CCTACCTGTA TCACCGGCGA CACCACACTA AATTTTTCGT GCGCATGCGC 4260

GACACCCGGC ACCGCGCCCA TTCGGCGCTT CGACGCGTAC GCAGCTCCAT GCGCGGTTCT 4320

AGGCGTGGCG GGCCGCCCGG AGACCCGGGC TACGCGGAAA CCCCCTACGC GAGCGTGTCC 4380 CACCACGCCG AGATCGACCG GTATGGGGAT TCCGACGGGG ACCCGATCTA CGACGAAGTG 4440

GCCCCCGACC ACGAGGCCGA GCTCTACGCC CGAGTGCAAC GCCCCGGGCC TGTGCCCGAC 4500

GCCGAGCCCA TTTACGACAC CGTGGAGGGG TATGCGCCAA GGTCCGCGGG GGAGCCGGTG 4560

TACAGCACCG TTCGGCGATG GTAGCCGTTT CGTTCGTTTT AATAAACCGA CGTTGTGCGT 4620

TTCACCATAC TTCGGCGCGC GCGTGTGTGT GTTTTTTTTG TGGTGTTTAT TTTCCCCCAC 4680 CCCTTCCTTT TCTTTCGGCC ACCACCCCCC TCCTCCCCCG TACTATACAA CAAAAAATAC 4740

CACACATACG ACCAAATACG GACAATCATT TCTGTCTTTA TTCGCTGTCA GAGAGTGGGG 4800

GCGTGAGCGT GGCAGGAGGG CGGGCCACGT CGGGGTCCCG CCGTCTGGTG TGACGCGATG 4860

GGGGGTCCGA TGCGCGCCGG TACTGGGGCC CCGGCGCCCG GGTGACCACG CGCATGTCGG 4920

GGGGCACGTA GAAGTTACCC TCTTCTTCGG ACTCGATGTC CACGACGTCA AATTCGTGGG 4980 CGGTCAGCGA GACGACCTCC CCGCCGTCGG TGATGATGAC GTTGTGTCGG CAGCAGCAGG 5040

GCCGCGCCCC GGAGAACGCG AGGCCCATAA CTTGGCGAGC GTATCGTCGA AGGCCAGGCG 5100

GCTGTTTCGC CGGATGTCCC GGTATATCCC CGGCTCGACG CGGACGGGGG TGATGATCAG 5160

GGCGATCGGA ACGGCCTGGT CCGGGAGGAT CGATGCCTTG GCGGGTCCGG GGGCCCCGCC 5220 ACGCCCGGCG GGCGCTCCGC GGCCGTCCTC CAGGCGGAAC GTCACGCCCT CCTCCGCGCC 5280

CGCGCGGTGC CTGCCGAGGA ACGTCACCAG GTGCGGTTGC AGGGGGCAGT CGGGAAAGTG 5340

GCTGTCGAGG GACGTTTCCC TGCACCAAGA TCTGTTTGAA GTTCGGGTGG CGGGGGTTGG 5400

CGAAGATGGG CTCGCGGCGA ACCAGCTCCC CGGAGCTCCA GGCCACGGGA GAGATGGTGC 5460 GACGCTCGAG GTCGGGGACG CCAAACAGAA GCACCTCCGA GACAACGCCG CTATTTAACT 5520

CCACCAGCGC CCGATCCGGG GCGGAGCATC GCCTTTTTTC GCCGGCGGCG CGGGAATCGA 5580

GCCAGTCCCG GTCTTGGGTG ACGAGCGCCT CCTCCGGGCC CGGGACGCGC CCGGGCGCGA 5640

AGTAGCGCAC GCCGGGGTTG GGGATGGACC GGATGAACGC CCGGAACGCC TCCGGCGATC 5700

GCCGCGCCAT CAGGTCCTCG TACGCGGAGG CCGCGGGGGC GCCGGGGTCC GCGGGGTCGA 5760 ACGCGTACTT GGCTCGGCAC TTAACCTCGT AGAAGGCCAG GGGGGTCTGG GGGGCGGGGG 5820

CCAGGTAGCC GTGAGGGTCC CTGGGGCACA CGAGGATGTC CAGGGACGCC CCCACCATGC 5880

CCGTGTGGCC GTCCATGAGG ACCCCGCACG CGTGCACGTT CTCCTCGGCG AGGTCCCCGG 5940

GTTGGTGAAA GACGAAGCGC CCGGCGTCGG CGTCGTCGTT GACGCCCGCG TCCGCGCGGC 6000

CCACGCAGTA GCGAAACAGC AGGTTTCGGG CCGTCGGCTC GTTCACCCGC CCGAACATCA 6060 CCGCCGACGA CTGGGCGTCC AGCCGCAGGC TGGCGTTGTG GGTGAGCCAC TGGGACGAGA 6120

AGCACGGACC CTGCGCGCCC CACCGCAGCG TGGAGGCGGT CGTCAGGCCC CGCCGAAGCA 6180

GGGCCCAGAG CTGGCAGTCG GCCTGGTTTT GCGTCGCCGC CTCGTAAAAT CCCATAAGCG 6240

GGCGGGGGGC GACGGCTTCG GCGGCGGACG GGGGGGCGCG GCGCGTCAGG CGCCAGAGGT 6300

GCCGGCCGAG CCCGCGGTCC ACCATGCCGG CCGCCTCCAG CGACACGACG AGGGAGCACA 6360 GATAGTCCAG GCGAGCCCAC AGGGGCCCGA TGGCCAGAGG GGAGCGGACG CCGCGCAGCA 6420

GGCCGCGCAG GTGGCGCTCG AACGTTTCCG CCAAGATATG GGGGGGCAGT GCGTTGGGGA 6480

TCGCCGACGC CGACCACATC GGGTCGGGGT CCGGGGGACC GGGGCTGCAG TCCGGGTCGA 6540

TGGCGTGTGC GCCCCCCGGC GAGAGGGGAA TGTCGGGGGT TGGCGGGCCG GATGAGGCCT 6600

CAGAGAGGGC CGGGGACGCG GGCCGGGCCT TTTCGCCCGG GGCCCCGCCG TCGGGTTGCC 6660 CACGTGGGGG GCTCTGGGGC CAATGGGAAC CCGGGGCCCC CGGTGAAGTG GGGCGGGGTG 6720

GGGCGGGGCG GGGCCCAAAG ACGGTCGCCA GATCTAGGCT GTTGGGTCGG GGCCGCTTCG 6780

GGGGACTATC GGGGTCGCGG GCGGGGTCCG CGGGGCGCTT GGCGCCGGGT GTTGCGGCGG 6840

CCGCCATTTT TACGAGCAGC CGAAGAGCTC GAGGGCGGAA GGGATCCTCA CGACAGAGAG 6900

TGGCGCGCGG CCGGGTTGGC GTGACAGAGG CGGGAGACCA GCACCAGCAG CGGCCTCAGC 6960 TCGGGCGGCA GCGACACCGA CGACAGGACG GCCTTGTGCG TGCGCTGGTA ATTTATACAC 7020

TGCTCCGTGA ACGCGCGCCG AATCTTGGGA TTGCGAAGGT GGCGCCGGAT GCCCTCCGGC 7080

ACGTCATACG CCAGGCCGTG GGTGTTGGTC TCGGCCGAGT TGACAAAGAG GGCGGGGTGC 7140

AGAACGCAGC GATAGGCGAG GAGGGCCACG GCAAAGTCCG GCGAGAGCTG GTTGTTAAAG 7200

TACTGGTAGC CCGGGACGCG GGTCACGGGG ACGCCCAGGC TCGGGGCCAC GTACACGCTA 7260 ACCAGCAGCT CCAGCAGCGT CTGCCCCAGG GCGTAGAGAT CGACCGCCAG CCCGACGTCG 7320

TGCTTCAGGG GGCGGTTGTT AAACTCGGCC CGCTCGTTGT TGAGGTACTT TACCAAGAGC 7380

TCCGGCGGCT GGTTGTACCC GTGCCCCACC AGAGTGTGAA AGTTGGCCGT GGTCAGGGCG 7440

GCGGGCATCC CAAACCCCCG GGGGGACTCG AGGTCCGGCT CCTGGAGGCA AAACTGGCCC 7500

CGGGATATCG TGGAGTTGGA GTTCAGGGTC ACCAGGCTAA AGTCGGCCAG GACGGCCCGC 7560 CGGAGCGACA CCGCGTCCGA TCGCAGCATC ACGAGGACGT TGGCGCACTT GATGTCCAGG 7620

TGGCTGATCC CGCACCTGGT GTTCAGGAAC ACCACGGCGC GCGCCAGGTC TGTGAAGCAG 7680

TGGTGGAGGG CCGTCGCGAC GGAGGGGGTG GTCGCGCGCA GGGACGCCAG CTGGCCGATG 7740

TACTTGCCGA GGTCCATGTC GTACGCGGGG AACACGATCT GGCGCTGCTG CAGCGAGAAC 7800 CCGAGCGGGG TGATAAAGCC GCGGATGTCG TGGGTGCGGC CGCCGCAAAA AGCGCACTCC 7860

CCCACGAGCA GGGTCGCGAC GAGCTCCACG GCAAACCACT CCTTTTCCCG GATGGTCTTC 7920

ACGGCCAGCT TGTGTTCGCA AATCAACTGC ACCTCGCCGT ACCCCCCCGA GCCCCCGAAG 7980

CTGCGGGCCC CGGGGATCTC CAGGGTCGTG TAGCGGAGGG CGGGGTTGAC GGCGAATACG 8040 GGGATGCATA GCTTGTGGAT GCGCGCGAGG GACAGGATGT GCGAGGGGGG CGACGGGGGC 8100

GAGGTCATGG CCGTCTCGGA CCTGCGCAGG GGCGGGCGCC TCAGCTTGGC CGCAGGGCCG 8160

GGGGCCTCGG GGGACGAGCG GCGACGAGAC GAGCGGCTCA CTCGCCATCG GGACAGTCCC 8220

GCGCGAAGCC GCTCCCGGAA GCTGGATCGG CGGCGGGACC CGGGGCGGGC TCCGGAGACG 8280

GCGCCGTCTC GGGGGGAGGG GCCGCTTGGG CGTCCGGACG CCCGGCGGCT GAGGGAGTGT 8340 ATGTAGGACG CGAGCCAGGC CTTGAAGGAG CGTCGGTGTG CACCTTGGGG GCTGATGTCA 8400

GCTGCCACAT GACTAGCAGG TCGCTGTCGC CCGGACTCAT CCATCCGTCC GCCAGGTCGC 8460

CGTCCCCCCA CAGAGACGCG TTCGCCGCGG CCTCTTCGAG CTGCTCCTCC TGGTCCGCAA 8520

GACGATCGTC CGCCGCGTCC AGGCGCTCGC TAAGCGCGGG ATCGAGGTAC CGTCGGTGTG 8580

CGGTTAGAAA ATCACGTCGC GCCGCTTGCT CTTCCACGCG AATTTTAACA CAGGTCGCTC 8640 GCTGTCGCAT CATCTCTAAG CGCGCGCGGG ACTTTAGCCG CGCCTCCAAT TCCAAGTGGG 8700

CCGCCTTGGC GGCCATAAAG GCGCCAACAA ACCTAGGATC TTGTGTACTC ACGCCCTCCC 8760

GGTGTAGCTG CAGGGTCTGG TCCCTGTACA CCTCGGCCCG GAGGTGCGTC TCGGCCAAAC 8820

GTCGGCGCAG GGCCGCGTGG CTGGCGTCTC GGCTCATCTC GCCGCCCCCG CGCGCGCCCG 8880

ACGTCGGACT CCTTCGCCCC GACCCCCCTG ACCTCAGCCG CCCCCGCCTC GCCCGCGATG 8940 TTTGGCCAGC AGCTGGCGTC CGACGTGCAG CAGTACCTGG AGCGCCTGGA GAAACAGAGG 9000

CAACAGAAGG TGGGCGTCGA CGAGGCGTCG GCGGGCCTGA CGCTCGGCGG CGATGCGCTG 9060

CGCGTCCCTT TTTTGGATTT TGCCACCGCG ACGCCCAAGC GCCACCAGAC CGTGGTCCCG 9120

GGCGTCGGGA CGCTCCACGA CTGCTGCGAG CACTCGCCGC TCTTCTCGGC CGTCGCGCGG 9180

CGGTTGCTGT TTAATAGCCT GGTGCCGGCG CAACTCAGGG GGCGTGACTT TGGGGGCGAC 9240 CACACGGCCA AGCTGGAGTT CCTGGCCCCC GAGCTGGTGC GGGCGGTGGC GCGCCTGCGG 9300

TTTCGGGAGT GCGCGCCGGA GGACGCCGTG CCCCAACGCA ACGCCTACTA CAGCGTCCTG 9360

AACACGTTTC AGGCCCTGCA CCGCTCCGAA GCCTTTCGGC AGTTGGTTCA CTTCGTGCGG 9420

GACTTCGCCC AGTTGTTGAA AACCTCGTTC CGGGCCTCTA GTCTCGCGGA GAATACGGGC 9480

CCCCCGAAGA AACGGGCCAA GGTGGACGTG GCCACCCACG GGCAGACGTA CGGCACCTTG 9540 GAGCTCTTCC AGAAAATGAT ACTAATGCAC GCGACCTACT TTCTGGCCGC CGTGCTGCTC 9600

GGGGACCACG CGGAGCAGGT CAACACGTTC CTGCGGCTCG TGTTCGAGAT CCCCCTGTTT 9660

AGCGACACGG CCGTGCGGCA CTTCCGCCAG CGCGCCACCG TGTTTCTAGT CCCCAGGCGC 9720

CACGGAAAGA CCTGGTTTTT GGTGCCCCTC ATCGCGCTGT CGCTCGCGTC CTTCCGGGGG 9780

ATCAAGATAG GCTACACGGC CCACATCCGC AAGGCGACCG AGCCCGTGTT TGATGAGATC 9840 GACGCCTGCC TGCGGGGCTG GTTTGGCTCG TCCCGGGTGG ACCACGTCAA GGGGGAAACC 9900

ATCTCGTTCT CGTTCCCGGA CGGCTCGCGC AGCACGATCG TGTTTGCCTC CAGCCACAAC 9960

ACGAACGTAA GTACGCCTTC CTCCCGCGGT GCCTGTTTCC CCGGTGCCGC CCTCCCCGAG 10020

ATCGACCGAC AGACAAACAC AGCCAGACGC GAGTGTGGGA CGACACGCCC GCAGCCCCCC 10080

CCGCCATGGC GGGGGGAAGC CTTACTGTTT ATTTGTAATC GGACGATGAG GCTCTGGCCA 10140 CGGCCCGCGC GACCGCGGGG CAGCTCGTTG CAAACAGGCG GCTGGTATAC GATGACAGAA 10200

CGCAGAGGCG CCACCCGGCG CTGGTCGGGC GGATGACGCT TTCCGCGCCG TCCCGGCCCA 10260

CGACGACCTC GTGCAGGTGG GCCGTGATGC GCGGGCGGCG GGTCGCCTGC CGCAGGATAA 10320

CCGCGTCCAC GGGGTGCCCG AAGAGGAGCT GACACAGGCT CGCGTCCCCC CGGACGGCCA 10380 GGGTGCGCTG GGCCATATTG GACCACATGC ACGGGGCGAC GCAGGGACAG GCCTCCGCCA 10440

CGGCGGGGGC GCGCCACAGC GCGTTGGCGG AATCGATGTG GGCCGTCGGG GCGCAGGCGC 10500

CGCCTCCTCC CGGGGGGTCG GTAATCCTGG ATAGCAGCCA TCCTAAATGG CGGGCCCGGC 10560

TGCCCGGGGG ACAGAGCGAC CCCAGGTCAT CATCCATGGC CCAGCAGTAT ATGCGGCCGC 10620 CGGGGAGGTG CCACCAGGCC CCCGGACCCA GGGCACAGCA CGCCCCCGGA TTCGGGGGCG 10680

GTTCCGTGGG TACCAGGTAG GCGCCGTCGA GCTCGTGGGC CACGGGCTCG TCCGCGAGCT 10740

GTTCGGCGGC GGGGTCGGGG GTTTCCTCCG GGGGGGAGGC AGCTTCCAGG TGGCCGAAGG 10800

CTAGGGTGCA CAGCAGCGGG GTCCGGGGGT GCGTTACGCT GCGGAGGTGG ACGGTGGCGC 10860

AGTAGCGGCG CTCGCGGTTA AAGAAAAAAA TGGCAAAAAA CGTGTTCGAA GGCAGGCGCA 10920 GCGCCTTGGG CCGCGTCAGG TACAGGAAAA TCTCGCAAAA AAGGGCACGC TCGGGGTCGG 10980

GGTCCGGAAG GGCCACCTGG CACAGCGGCT CGGTGAGGAC CGTGAGGCAC CGAAAAATCT 11040

TAAGCCGCTC GTCCCCCCGA ACGACGCGCC ACACGAAAAC AGAGTTGGCG ATGCGCGCGA 11100

CAAGGTCGGC TTCGGGCCCC GGGTCGGGGG CGCGCGCGTC GGGGGGGGCG CCCCGGTGAC 11160

CCGGCGGGGC CGCGGCTCCC GGGGGGCCTG GCGTCCCCTG GGGACGCCAC ACTGCCCGCT 11220 GTGCCATGTT GGTGGTGGGG AAGGGACCGG AGACGCACCA AAAGCAGAGG GGCCAGCGCG 11280

TGTATGACTT GGGGGGGGGG GTGGGTGACC GGTGGAACAA AAACACGCGT CAGCGGACAA 11340

GGCCGGGTCC CGTACCCGCC CCGCGACAGA ACCGGAGTCC GACGGCACGC GCGACGGGGT 11400

CTGCGAGGCT GAGGTACGCC GCGGTGTTAA TGGTAAACGC AAAGCCTCCC GGAAAGACCA 11460

CTAGCCCGCA GAGGCGGCGA TTGAACCCAA GGCAGAGGTA CGCGTAGCTC TCTCCCGGAA 11520 GGTATTGCTC GCAAACCCTG TGCGGGGCAG TGGAGGGGCT GCCCTCCATG AAGCGACATT 11580

TACTCTGCTC GCGTCCATTG ACGTCACCGT CAATCACCAC TGCGATTGGA CGGTTGGTAA 11640

GGCGCAGCGT GTCTCCGCTG GTGCTG AGT AGTCAAACGC GTAGTGGGCG TCGGAGTCGG 11700

CGAAGCGGGC GGGGATGTCG TCGCTGAGAG GGACGAGCCG CCGCCGCCGC CCCCGACCGC 11760

CCTGGCCGCC CAGATGCGCC AGCACGGCCA GGGCGTACGC GGTGTGAAAG AACGCGTCGG 11820 GGGCGGTCCC CTCGAGGGCG CGCATCAGGT TCTCCAGGAG CACGGGGAAG CGCCGCGTCA 11880

CCTCCCCTAG CCACTCGCTC TGGTGGGGGC CAAAGTCGTA GCGCAGGCGC TGGAAGATGC 11940

GCGGGCCGCC TTGGAGCGCG GCCCGGATAG AGTGGCCCAG GGCCCGCAGA CACGCGATCT 12000

GGATGCGCGC GACGAAGGCC ACCTCGGCCG CGATGTCAAA GGGCTGCAGC ACGGGGCGCG 12060

GGTGGCGCAG GGGTCCCTCG AGCGCGGGAA AGCGACGCAG CAGCGCCGTC TGGGCCGCGG 12120 GGGACAGCTG GTGGGGGCGC ACGACGCGCT CGGCGGCACA GGCCTCCGTC AGGGCCGTGG 12180

CCAGATAGGA GGACAACAGC GGGGGGCGGG TGCGTCGCCC GCCCCACGCC ACCGAATTTT 12240

TGTAGGAGAC GACGACGAAG CGCTGCTTGG TCCCGTAGTG ATGGCGCAGG ACCACGGAGA 12300

TGGAGCGACG GCTCCACAGC CAGTCGGGCC GGTCGCCGCC GGCCAGAGGT TCCCACCCGC 12360

GGTCCAGCCA CTCGACCAGC GATCGCGGCT TGGCGGTCCC CGGCACGAGG GTGAGCACGT 12420 CGTTGAGGAC GTCATCGCCC GCGGCCCGGG GGCCCCCCGG GGTGGCAAAG CGCCCCCCGC 12480

CGGGCGGTTC CAGGCCCGCC AGCACCGCCT CCGCGTCCGA CGCGCCCAGG GCTCCCCCGC 12540

TGACGGCNTG GTGGACCAGG GCGCCCTGGC GGAGCCCCGA GGNGACGCCG GAGGCCGCGT 12600

GCTTGGGGCG CGCGCGGACC GGGTGGCGGC GGGTGACGTC CTGCACGGCC CGCTGATCAA 12660

GCTTGTCGAT ACCGTGGACT CTGAAGTAGC CCGTAAGGAA 12701

(2) INFORMATION FOR SEQ ID NO: 27:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 857 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 27:

Met Ala Glu Thr Met Asn Val Ala Thr Cys Thr His Gin Thr His His 1 5 10 15

Ala Ala Arg Ala Pro Gly Ala Thr Ser Ala Pro Gly Ala Ala Ser Gly

20 25 30

Asp Pro Leu Gly Ala Arg Arg Pro Ile Gly Asp Asp Glu Cys Glu Gin 35 40 45

Tyr Thr Ser Ser Val Ser Leu Ala Arg Met Leu Tyr Gly Gly Asp Leu

50 55 60

Ala Glu Trp Val Pro Arg Val His Pro Lys Thr Thr lie Glu Arg Gin 65 70 75 80 Gin His Gly Pro Val Thr Phe Pro Asp Ala Ser Ala Pro Thr Ala Arg

85 90 95

Cys Val Thr Val Val Arg Ala Pro Met Gly Ser Gly Lys Thr Thr Ala

100 105 110

Leu lie Arg Trp Leu Gly Glu Ala Ile His Ser Pro Asp Thr Ser Val 115 120 125

Leu Val Val Ser Cys Arg Arg Ser Phe Thr Gin Thr Leu Ala Thr Arg

130 135 140

Phe Ala Glu Ser Gly Leu Pro Asp Phe Val Thr Tyr Phe Ser Ser Thr 145 150 155 160 Asn Tyr Ile Met Asn Asp Arg Pro Phe His Arg Leu Ile Val Gin Val

165 170 175

Glu Ser Leu His Arg Val Gly Pro Asn Leu Leu Asn Asn Tyr Asp Val

180 185 190

Leu Val Leu Asp Glu Val Met Ser Thr Leu Gly Gin Lys Pro Thr Met 195 200 205

Gin Gin Leu Gly Arg Val Asp Ala Leu Met Leu Arg Leu Leu Arg Thr

210 215 220

Cys Pro Arg Ile Ile Ala Met Asp Ala Thr Ala Asn Ala Gin Leu Val 225 230 235 240 Asp Phe Leu Cys Ser Leu Arg Gly Glu Lys Asn Val His Val Val Ile

245 250 255

Gly Glu Tyr Ala Met Pro Gly Phe Ser Ala Arg Arg Cys Leu Phe Leu 260 265 270 Pro Arg Leu Gly Pro Glu Val Leu Gin Ala Ala Leu Arg Pro Pro Gly

275 280 285

Pro Ala Gly Gly Ala Pro Pro Pro Asp Ala Pro Pro Asp Ala Thr Phe

290 295 300 Phe Gly Glu Val Glu Ala Arg Leu Ala Gly Gly Asp Asn Val Cys Ile

305 310 315 320

Phe Leu Ser Thr Val Ser Phe Ala Glu Val Val Ala Arg Phe Cys Arg

325 330 335

Gin Phe Thr Asp Arg Val Leu Leu Leu His Ser Leu Thr Pro Pro Gly 340 345 350

Glu Val Thr Thr Trp Gly Arg Tyr Arg Val Val Ile Tyr Thr Thr Val

355 360 365

Val Thr Val Gly Leu Ser Phe Asp Pro Pro His Phe Asp Ser Met Phe

370 375 380 Ala Tyr Val Lys Pro Met Asn Tyr Gly Pro Asp Met Val Ser Val Tyr

385 390 395 400

Gin Ser Leu Gly Arg Val Arg Thr Leu Arg Lys Gly Glu Leu Leu Ile

405 410 415

Tyr Met Asp Gly Ser Gly Ala Arg Ser Glu Pro Val Phe Thr Pro Met 420 425 430

Leu Leu Asn His Val Val Ser Ala Ser Gly Gin Trp Pro Ala Gin Phe

435 440 445

Ser Gin Val Thr Asn Leu Leu Cys Arg Arg Phe Lys Gly Arg Cys Asp

450 455 460 Ala Ser His Ala Asp Ala Ala Gin Arg Ser Arg Ile Tyr Ser Lys Phe

465 470 475 480

Arg Tyr Lys His Tyr Phe Glu Arg Cys Thr Leu Ala Cys Leu Ala Asp

485 490 495

Ser Leu Asn Ile Leu His Met Leu Leu Thr Leu Asn Cys Met His Val 500 505 510

Arg Phe Trp Gly His Asp Ala Ala Leu Thr Pro Arg Asn Phe Cys Leu

515 520 525

Phe Leu Arg Gly Ile His Phe Asp Ala Leu Arg Ala Gin Arg Asp Leu

530 535 540 Arg Glu Leu Arg Cys Gin Asp Pro Asp Thr Ser Leu Ser Ala Gin Ala

545 550 555 560

Ala Glu Thr Glu Glu Val Gly Leu Phe Val Glu Lys Tyr Leu Arg Pro

565 570 575

Asp Val Ala Pro Ala Glu Val Val Met Arg Gin Ser Leu Val Gly Arg 580 585 590

Thr Arg Phe Ile Tyr Leu Val Leu Leu Glu Ala Cys Leu Arg Val Pro

595 600 605

Met Ala Ala His Ser Ser Ala Ile Phe Arg Arg Leu Tyr Asp His Tyr 610 615 620

Ala Thr Gly Val Ile Pro Thr Ile Asn Ala Ala Gly Glu Leu Glu Leu 625 630 635 640

Val His Pro Thr Leu Asn Val Ala Pro Val Trp Glu Leu Phe Arg Leu 645 650 655

Cys Ser Thr Met Ala Ala Cys Leu Gin Trp Asp Ser Met Ala Gly Gly

660 665 670

Ser Gly Arg Thr Phe Ser Pro Glu Asp Val Leu Glu Leu Leu Asn Pro 675 680 685 His Tyr Asp Arg Tyr Met Gin Leu Val Phe Glu Leu Gly His Cys Asn 690 695 700

Val Thr Asp Gly Pro Leu Leu Ser Glu Asp Ala Val Lys Arg Val Ala 705 710 715 720

Asp Ala Leu Ser Gly Cys Pro Pro Arg Gly Ser Val Ser Glu Thr Glu 725 730 735

His Ala Leu Ser Leu Phe Lys Ile Ile Trp Gly Glu Leu Phe Gly Val

740 745 750

Gin Leu Ala Lys Ser Thr Gin Thr Phe Pro Gly Ala Gly Arg Val Lys 755 760 765 Asn Leu Thr Lys Arg Ala Ile Val Glu Leu Leu Asp Ala His Arg Ile 770 775 780

Asp His Ser Ala Cys Arg Thr Gin Leu Tyr Ala Leu Leu Met Ala His 785 790 795 800

Lys Arg Glu Phe Ala Gly Ala Arg Phe Lys Leu Arg Ala Pro Ala Trp 805 810 815

Gly Arg Cys Leu Arg Thr His Ala Ser Gly Ala Gin Pro Asn Thr Asp

820 825 830

Ile Ile Ala Ala Leu Ser Glu Leu Pro Thr Glu Ala Trp Pro Met Met 835 840 845 Gin Gly Ala Val Asn Phe Ser Thr Leu 850 855

(2) INFORMATION FOR SEQ ID NO: 28:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 470 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2ϊ Val Tyr Cys Ser His Ser Ser Ser Pro Met Gly Arg Arg Ala Pro Arg

1 5 10 15

Gly Ser Pro Glu Ala Ala Pro Gly Ala Asp Val Ala Pro Gly Ala Arg 20 25 30

Ala Ala Trp Trp Val Trp Cys Val Gin Val Ala Thr Phe Ile Val Ser

35 40 45

Ala Ile Cys Val Val Gly Leu Leu Val Leu Ala Ser Val Phe Arg Asp 50 55 60 Arg Phe Pro Cys Leu Tyr Ala Pro Ala Thr Ser Tyr Ala Glu Ala Asn 65 70 75 80

Ala Thr Val Glu Val Arg Gly Gly Val Ala Val Pro Leu Arg Leu Asp

85 90 95

Thr Gin Ser Leu Leu Ala Thr Tyr Ala Ile Thr Ser Thr Leu Leu Leu 100 105 110

Ala Ala Ala Val Tyr Ala Ala Val Gly Ala Val Thr Ser Arg Tyr Glu

115 120 125

Arg Ala Leu Asp Ala Ala Arg Arg Leu Ala Ala Ala Arg Met Ala Met

130 135 140 Pro His Ala Thr Leu Ile Ala Gly Asn Val Cys Ala Trp Leu Leu Gin

145 150 155 160

Ile Thr Val Leu Leu Leu Ala His Arg Ile Ser Gin Leu Ala His Leu

165 170 175

Ile Tyr Val Leu His Phe Ala Cys Leu Val Tyr Leu Ala Ala His Phe 180 185 190

Cys Thr Arg Gly Val Leu Ser Gly Thr Tyr Leu Arg Gin Val His Gly

195 200 205

Leu Ile Asp Pro Ala Pro Thr His His Arg Ile Val Gly Pro Val Arg

210 215 220 Ala Val Met Thr Asn Ala Leu Leu Leu Gly Thr Leu Leu Cys Thr Ala

225 230 235 240

Ala Ala Ala Val Ser Leu Asn Thr Ile Ala Ala Leu Asn Phe Asn Phe

245 250 255

Ser Ala Pro Ser Met Leu Ile Cys Leu Thr Thr Leu Phe Ala Leu Leu 260 265 270

Val Val Ser Leu Leu Leu Val Val Glu Gly Val Leu Cys His Tyr Val

275 280 285

Arg Val Leu Val Gly Pro His Leu Gly Ala Ile Ala Ala Thr Gly Ile 290 295 300 Val Gly Leu Ala Cys Glu His Tyr His Thr Gly Gly Tyr Tyr Val Val 305 310 315 320

Glu Gin Gin Trp Pro Gly Ala Gin Thr Gly Val Arg Val Val Ala Ala 325 330 335 Phe Ala Met Ala Val Leu Arg Cys Thr Arg Ala Tyr Leu Tyr His Arg

340 345 350

Arg His His Thr Lys Phe Phe Val Arg Met Arg Asp Thr Arg His Arg 355 360 365 Ala His Ser Ala Leu Arg Arg Val Arg Ser Ser Met Arg Gly Ser Arg 370 375 380

Arg Gly Gly Pro Pro Gly Asp Pro Gly Tyr Ala Glu Thr Pro Tyr Ala 385 390 395 400

Ser Val Ser His His Ala Glu Ile Asp Arg Tyr Gly Asp Ser Asp Gly 405 410 415

Asp Pro Ile Tyr Asp Glu Val Ala Pro Asp His Glu Ala Glu Leu Tyr

420 425 430

Ala Arg Val Gin Arg Pro Gly Pro Val Pro Asp Ala Glu Pro Ile Tyr 435 440 445 Asp Thr Val Glu Gly Tyr Ala Pro Arg Ser Ala Gly Glu Pro Val Tyr 450 455 460

Ser Thr Val Arg Arg Trp 465 470

(2) INFORMATION FOR SEQ ID NO: 29:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 687 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 29:

Met Ala Ala Ala Ala Thr Pro Gly Ala Lys Arg Pro Ala Asp Pro Ala

1 5 10 15

Arg Asp Pro Asp Ser Pro Pro Lys Arg Pro Arg Pro Asn Ser Leu Asp 20 25 30

Leu Ala Thr Val Phe Gly Pro Arg Pro Ala Pro Pro Arg Pro Thr Ser

35 40 45

Pro Gly Ala Pro Gly Ser His Trp Pro Gin Ser Pro Pro Arg Gly Gin 50 55 60 Pro Asp Gly Gly Ala Pro Gly Glu Lys Ala Arg Pro Asp Ala Leu Ser 65 70 75 80

Glu Ala Ser Ser Gly Pro Pro Thr Pro Asp Ile Pro Leu Ser Pro Gly 85 90 95 Gly Ala His Ala Ile Asp Pro Asp Cys Ser Pro Gly Pro Pro Asp Pro

100 105 110

Asp Pro Met Trp Ser Ala Ser Ala Ile Pro Asn Ala Leu Pro Pro His 115 120 125 Ile Leu Ala Glu Thr Phe Glu Arg His Leu Arg Gly Leu Leu Arg Gly 130 135 140

Val Arg Ser Pro Leu Ala Ile Gly Pro Leu Trp Ala Arg Leu Asp Tyr 145 150 155 160

Leu Cys Ser Leu Val Val Ser Leu Glu Ala Ala Gly Met Val Asp Arg 165 170 175

Gly Leu Gly Arg His Leu Trp Arg Leu Thr Arg Arg Ala Pro Pro Ser

180 185 190

Ala Ala Glu Ala Val Ala Pro Arg Pro Leu Met Gly Phe Tyr Glu Ala 195 200 205 Ala Thr Gin Asn Gin Ala Asp Cys Gin Leu Trp Ala Leu Leu Arg Arg 210 215 220

Gly Leu Thr Thr Ala Ser Thr Leu Arg Trp Gly Ala Gin Gly Pro Cys 225 230 235 240

Phe Ser Ser Gin Trp Leu Thr His Asn Ala Ser Leu Arg Leu Asp Ala 245 250 255

Gin Ser Ser Ala Val Met Phe Gly Arg Val Asn Glu Pro Thr Ala Arg

260 265 270

Asn Leu Leu Phe Arg Tyr Cys Val Gly Arg Ala Asp Ala Gly Val Asn 275 280 285 Asp Asp Ala Asp Ala Gly Arg Phe Val Phe His Gin Pro Gly Asp Leu 290 295 300

Ala Glu Glu Asn Val His Ala Cys Gly Val Leu Met Asp Gly His Thr 305 310 315 320

Gly Met Val Gly Ala Ser Leu Asp Ile Leu Val Cys Pro Arg Asp Pro 325 330 335

His Gly Tyr Leu Ala Pro Ala Pro Gin Thr Pro Leu Ala Phe Tyr Glu

340 345 350

Val Lys Cys Arg Ala Lys Tyr Ala Phe Asp Pro Ala Asp Pro Gly Ala 355 360 365 Pro Ala Ala Ser Ala Tyr Glu Asp Leu Met Ala Arg Arg Ser Pro Glu 370 375 380

Ala Phe Arg Ala Phe Ile Arg Ser Ile Pro Asn Pro Gly Val Arg Tyr 385 390 395 400

Phe Ala Pro Gly Arg Val Pro Gly Pro Glu Glu Ala Leu Val Thr Gin 405 410 415

Asp Arg Asp Trp Leu Asp Ser Arg Ala Ala Gly Glu Lys Arg Arg Cys

420 425 430

Ser Ala Pro Asp Arg Ala Leu Val Glu Leu Asn Ser Gly Val Val Ser 435 440 445

Glu Val Leu Leu Phe Gly Val Pro Asp Leu Glu Arg Arg Thr Ile Ser

450 455 460

Pro Val Ala Trp Ser Ser Gly Glu Leu Val Arg Arg Glu Pro Ile Phe 465 470 475 480

Ala Asn Pro Arg His Pro Asn Phe Lys Gin Ile Leu Val Gin Gly Asn

485 490 495

Val Pro Arg Gin Pro Leu Ser Arg Leu Pro Pro Ala Thr Ala Pro Gly 500 505 510 Asp Val Pro Arg Gin Ala Pro Arg Gly Arg Gly Gly Gly Arg Asp Val 515 520 525

Pro Pro Gly Gly Arg Pro Arg Ser Ala Arg Arg Ala Trp Arg Gly Pro

530 535 540

Arg Thr Arg Gin Gly Ile Asp Pro Pro Gly Pro Gly Arg Ser Asp Arg 545 550 555 560

Pro Asp His His Pro Arg Pro Arg Arg Ala Gly Asp Ile Pro Gly His

565 570 575

Pro Ala Lys Gin Pro Pro Gly Leu Arg Arg Tyr Ala Arg Gin Val Met 580 585 590 Gly Leu Ala Phe Ser Gly Ala Arg Pro Cys Cys Cys Arg His Asn Val 595 600 605

Ile Ile Thr Asp Gly Gly Glu Val Val Ser Leu Thr Ala His Glu Phe

610 615 620

Asp Val Val Asp Ile Glu Ser Glu Glu Glu Gly Asn Phe Tyr Val Pro 625 630 635 640

Pro Asp Met Arg Val Val Thr Arg Ala Pro Gly Pro Gin Tyr Arg Arg

645 650 655

Ala Ser Asp Pro Pro Ser Arg His Thr Arg Arg Arg Asp Pro Asp Val 660 665 670 Ala Arg Pro Pro Ala Thr Leu Thr Pro Pro Leu Ser Asp Ser Glu 675 680 685

(2) INFORMATION FOR SEQ ID NO: 30:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 107 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 30: Val Thr Phe Leu Gly Arg His Arg Ala Gly Ala Glu Glu Gly Val Thr

1 5 10 15

Phe Arg Leu Glu Asp Gly Arg Gly Ala Pro Ala Gly Arg Gly Gly Ala 20 25 30

Pro Gly Pro Ala Lys Ala Ser Ile Leu Pro Asp Gin Ala Val Pro Ile

35 40 45

Ala Leu Ile lie Thr Pro Val Arg Val Glu Pro Gly Ile Tyr Arg Asp 50 55 60 Ile Arg Arg Asn Ser Arg Leu Ala Phe Asp Asp Thr Leu Ala Lys Leu 65 70 75 80

Trp Ala Ser Arg Ser Pro Gly Arg Gly Pro Ala Ala Ala Asp Thr Thr

85 90 95

Ser Ser Ser Pro Thr Ala Gly Arg Ser Ser Arg 100 105

(2) INFORMATION FOR SEQ ID NO: 31:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 525 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 31:

Val Gly Gly Arg Arg Pro Gly Gly Arg Met Asp Glu Ser Gly Arg Gin 1 5 10 15

Arg Pro Ala Ser His Val Ala Ala Asp Ile Ser Pro Gin Gly Ala His

20 25 30

Arg Arg Ser Phe Lys Ala Trp Leu Ala Ser Tyr Ile His Ser Leu Ser 35 40 45 Arg Arg Ala Ser Gly Arg Pro Ser Gly Pro Ser Pro Arg Asp Gly Ala 50 55 60

Val Ser Gly Ala Arg Pro Gly Ser Arg Arg Arg Ser Ser Phe Arg Glu 65 70 75 80

Arg Leu Arg Ala Gly Leu Ser Arg Trp Arg Val Ser Arg Ser Ser Arg 85 90 95

Arg Arg Ser Ser Pro Glu Ala Pro Gly Pro Ala Ala Lys Leu Arg Arg

100 105 110

Pro Pro Leu Arg Arg Ser Glu Thr Ala Met Thr Ser Pro Pro Ser Pro 115 120 125

Pro Ser His Ile Leu Ser Leu Ala Arg Ile His Lys Leu Cys Ile Pro

130 135 140

Val Phe Ala Val Asn Pro Ala Leu Arg Tyr Thr Thr Leu Glu Ile Pro 145 150 155 160

Gly Ala Arg Ser Phe Gly Gly Ser Gly Gly Tyr Gly Glu Val Gin Leu

165 170 175

Ile Cys Glu His Lys Leu Ala Val Lys Thr Ile Arg Glu Lys Glu Trp 180 185 190 Phe Ala Val Glu Leu Val Ala Thr Leu Leu Val Gly Glu Cys Ala Phe 195 200 205

Cys Gly Gly Arg Thr His Asp Ile Arg Gly Phe Ile Thr Pro Leu Gly

210 215 220

Phe Ser Leu Gin Gin Arg Gin Ile Val Phe Pro Ala Tyr Asp Met Asp 225 230 235 240

Leu Gly Lys Tyr Ile Gly Gin Leu Ala Ser Leu Arg Ala Thr Thr Pro

245 250 255

Ser Val Ala Thr Ala Leu His His Cys Phe Thr Asp Leu Ala Arg Ala 260 265 270 Val Val Phe Leu Asn Thr Arg Cys Gly Ile Ser His Leu Asp Ile Lys 275 280 285

Cys Ala Asn Val Leu Val Met Leu Arg Ser Asp Ala Val Ser Leu Arg

290 295 300

Arg Ala Val Leu Ala Asp Phe Ser Leu Val Thr Leu Asn Ser Asn Ser 305 310 315 320

Thr Ile Ser Arg Gly Gin Phe Cys Leu Gin Glu Pro Asp Leu Glu Ser

325 330 335

Pro Arg Gly Phe Gly Met Pro Ala Ala Leu Thr Thr Ala Asn Phe His 340 345 350 Thr Leu Val Gly His Gly Tyr Asn Gin Pro Pro Glu Leu Leu Val Lys 355 360 365

Tyr Leu Asn Asn Glu Arg Ala Glu Phe Asn Asn Arg Pro Leu Lys His

370 375 380

Asp Val Gly Leu Ala Val Asp Leu Tyr Ala Leu Gly Gin Thr Leu Leu 385 390 395 400

Glu Leu Leu Val Ser Val Tyr Val Ala Pro Ser Leu Gly Val Pro Val

405 410 415

Thr Arg Val Pro Gly Tyr Gin Tyr Phe Asn Asn Gin Leu Ser Pro Asp 420 425 430 Phe Ala Val Leu Ala Tyr Arg Cys Val Leu His Pro Ala Leu Phe Val 435 440 445

Asn Ser Ala Glu Thr Asn Thr His Gly Leu Ala Tyr Asp Val Pro Glu 450 455 460 Gly Ile Arg Arg His Leu Arg Asn Pro Lys Ile Arg Arg Ala Phe Thr 465 470 475 480

Glu Gin Cys Ile Asn Tyr Gin Arg Thr His Lys Ala Val Leu Ser Ser 485 490 495 Val Ser Leu Pro Pro Glu Leu Arg Pro Leu Leu Val Leu Val Ser Arg 500 505 510

Leu Cys His Ala Asn Pro Ala Ala Arg His Ser Leu Ser 515 520 525

(2) INFORMATION FOR SEQ ID NO: 32:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 79 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 32:

Met Ala Val Ser Asp Leu Arg Arg Gly Gly Arg Leu Ser Leu Ala Ala

1 5 10 15

Gly Pro Gly Ala Ser Gly Asp Glu Arg Arg Arg Asp Glu Arg Leu Thr 20 25 30

Arg His Arg Asp Ser Pro Ala Arg Ser Arg Ser Arg Lys Leu Asp Arg

35 40 45

Arg Arg Asp Pro Gly Arg Ala Pro Glu Thr Ala Pro Ser Arg Gly Glu 50 55 60 Gly Pro Leu Gly Arg Pro Asp Ala Arg Arg Leu Arg Glu Cys Met 65 70 75

(2) INFORMATION FOR SEQ ID NO: 33:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 217 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:33: Met Ser Arg Asp Ala Ser His Ala Ala Leu Arg Arg Arg Leu Ala Glu

1 5 10 15

Thr His Leu Arg Ala Glu Val Tyr Arg Asp Gin Thr Leu Gin Leu His 20 25 30

Arg Glu Gly Val Ser Thr Gin Asp Pro Arg Phe Val Gly Ala Phe Met

35 40 45

Ala Ala Lys Ala Ala His Leu Glu Leu Glu Ala Arg Leu Lys Ser Arg 50 55 60 Ala Arg Leu Glu Met Met Arg Gin Arg Ala Thr Cys Val Lys Ile Arg 65 70 75 80

Val Glu Glu Gin Ala Ala Arg Arg Asp Phe Leu Thr Ala His Arg Arg

85 90 95

Tyr Leu Asp Pro Ala Leu Ser Leu Asp Ala Ala Asp Asp Arg Leu Ala 100 105 110

Asp Gin Glu Glu Gin Leu Glu Glu Ala Ala Ala Asn Ala Ser Leu Trp

115 120 125

Gly Asp Gly Asp Leu Ala Asp Gly Trp Met Ser Pro Gly Asp Ser Asp

130 135 140 Leu Leu Val Met Trp Gin Leu Thr Ser Ala Pro Lys Val His Thr Asp

145 150 155 160

Ala Pro Ser Arg Pro Gly Ser Arg Pro Thr Tyr Thr Pro Ser Ala Ala

165 170 175

Gly Arg Pro Asp Ala Gin Ala Ala Pro Pro Pro Glu Thr Ala Pro Ser 180 185 190

Pro Glu Pro Ala Pro Gly Pro Ala Ala Asp Pro Ala Ser Gly Ser Gly

195 200 205

Phe Ala Arg Asp Cys Pro Asp Gly Glu 210 215

(2) INFORMATION FOR SEQ ID NO: 34:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 493 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 34:

Val Tyr Ser Arg Pro Pro Gly Val Ala Ala Gly Ser Gly Pro Cys Thr 1 5 10 15

Pro Arg Pro Gly Gly Ala Ser Arg Pro Asn Val Gly Ala Gly Pro Arg

20 _ 25 30

Gly Trp Arg Leu Gly Ser Ser Arg Arg Pro Arg Ala Arg Pro Thr Ser 35 40 45

Asp Ser Phe Ala Pro Thr Pro Leu Thr Ser Ala Ala Pro Asp Ala Met

50 55 60

Phe Gly Gin Gin Leu Ala Ser Asp Val Gin Gin Tyr Leu Glu Arg Leu 65 70 75 80 Glu Lys Gin Arg Gin Gin Lys Val Gly Val Asp Glu Ala Ser Ala Gly

85 90 95

Leu Thr Leu Gly Gly Asp Ala Leu Arg Val Pro Phe Leu Asp Phe Ala 100 105 110

Thr Ala Thr Pro Lys Arg His Gin Thr Val Val Pro Gly Val Gly Thr 115 120 125

Leu His Asp Cys Cys Glu His Ser Pro Leu Phe Ser Ala Val Ala Arg

130 135 140

Arg Leu Leu Phe Asn Ser Leu Val Pro Ala Gin Leu Arg Gly Arg Asp 145 150 155 160 Phe Gly Gly Asp His Thr Ala Lys Leu Glu Phe Leu Ala Pro Glu Leu

165 170 175

Val Arg Ala Val Ala Arg Leu Arg Phe Arg Glu Cys Ala Pro Glu Asp 180 185 190

Ala Val Pro Gin Arg Asn Ala Tyr Tyr Ser Val Leu Asn Thr Phe Gin 195 200 205

Ala Leu His Arg Ser Glu Ala Phe Arg Gin Leu Val His Phe Val Arg

210 215 220

Asp Phe Ala Gin Leu Leu Lys Thr Ser Phe Arg Ala Ser Ser Leu Ala 225 230 235 240 Glu Asn Thr Gly Pro Pro Lys Lys Arg Ala Lys Val Asp Val Ala Thr

245 250 255

His Gly Gin Thr Tyr Gly Thr Leu Glu Leu Phe Gin Lys Met Ile Leu 260 265 270

Met His Ala Thr Tyr Phe Leu Ala Ala Val Leu Leu Gly Asp His Ala 275 280 285

Glu Gin Val Asn Thr Phe Leu Arg Leu Val Phe Glu Ile Pro Leu Phe

290 295 300

Ser Asp Thr Ala Val Arg His Phe Arg Gin Arg Ala Thr Val Phe Leu 305 310 315 320 Val Pro Arg Arg His Gly Lys Thr Trp Phe Leu Val Pro Leu Ile Ala

325 330 335

Leu Ser Leu Ala Ser Phe Arg Gly Ile Lys Ile Gly Tyr Thr Ala His 340 345 350 Ile Arg Lys Ala Thr Glu Pro Val Phe Asp Glu Ile Asp Ala Cys Leu

355 360 365

Arg Gly Trp Phe Gly Ser Ser Arg Val Asp His Val Lys Gly Glu Thr

370 375 380 Ile Ser Phe Ser Phe Pro Asp Gly Ser Arg Ser Thr Ile Val Phe Ala

385 390 395 400

Ser Ser His Asn Thr Asn Val Ser Thr Pro Ser Ser Arg Gly Ala Cys

405 410 415

Phe Pro Gly Ala Ala Leu Pro Glu Ile Asp Arg Gin Thr Asn Thr Ala 420 425 430

Arg Arg Glu Cys Gly Thr Trp Gin Pro Pro Pro Pro Trp Arg Gly Glu

435 440 445

Ala Leu Leu Phe Ile Cys Asn Arg Thr Met Arg Leu Trp Pro Arg Pro 450 455 460 Ala Arg Pro Arg Gly Ser Ser Leu Gin Thr Gly Gly Trp Tyr Thr Met 465 470 475 480

Thr Glu Arg Arg Gly Ala Thr Arg Arg Trp Ser Gly Gly 485 490

(2) INFORMATION FOR SEQ ID NO: 35:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 399 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 35:

Val Phe Leu Phe His Arg Ser Pro Thr Pro Pro Pro Lys Ser Tyr Thr

1 5 10 15

Arg Trp Pro Leu Cys Phe Trp Cys Val Ser Gly Pro Phe Pro Thr Thr 20 25 30

Asn Met Ala Gin Arg Ala Val Trp Arg Pro Gin Gly Thr Pro Gly Pro

35 40 45

Pro Gly Ala Ala Ala Pro Pro Gly His Arg Gly Ala Pro Pro Asp Ala 50 55 60 Arg Ala Pro Asp Pro Gly Pro Glu Ala Asp Leu Val Ala Arg Ile Ala 65 70 75 80

Asn Ser Val Phe Val Trp Arg Val Val Arg Gly Asp Glu Arg Leu Lys 85 90 95 Ile Phe Arg Cys Leu Thr Val Leu Thr Glu Pro Leu Cys Gin Val Pro

100 105 110

Asp Pro Asp Pro Glu Arg Ala Leu Phe Cys Glu Ile Phe Leu Tyr Leu 115 120 125 Trp Lys Ala Leu Arg Leu Pro Ser Asn Thr Phe Phe Ala Ile Phe Phe 130 135 140

Phe Asn Arg Glu Arg Arg Tyr Cys Ala Thr Val His Leu Arg Ser Val 145 150 155 160

Thr His Pro Arg Thr Pro Leu Leu Cys Thr Leu Ala Phe Gly His Leu 165 170 175

Glu Ala Asp Pro Glu Glu Thr Pro Asp Pro Ala Ala Glu Gin Leu Ala

180 185 190

Asp Glu Pro Val Ala His Glu Leu Asp Gly Ala Tyr Leu Val Pro Thr 195 200 205 Glu Pro Pro Pro Asn Pro Gly Ala Cys Cys Ala Leu Gly Pro Gly Ala 210 215 220

Trp Trp His Leu Pro Gly Gly Arg Ile Tyr Cys Trp Ala Met Asp Asp 225 230 235 240

Asp Leu Gly Ser Leu Cys Pro Pro Gly Ser Arg Ala Arg His Leu Gly 245 250 255

Trp Leu Leu Ser Arg Ile Thr Asp Pro Pro Gly Gly Gly Gly Ala Cys

260 265 270

Ala Pro Thr Ala His Ile Asp Ser Ala Asn Ala Leu Trp Arg Ala Pro 275 280 285 Ala Val Ala Glu Ala Cys Pro Cys Val Ala Pro Cys Met Trp Ser Asn 290 295 300

Met Ala Gin Arg Thr Leu Ala Val Arg Gly Asp Ala Ser Leu Cys Gin 305 310 315 320

Leu Leu Phe Gly His Pro Val Asp Ala Val Ile Leu Arg Gin Ala Thr 325 330 335

Arg Arg Pro Arg Ile Thr Ala His Leu His Glu Val Val Val Gly Arg

340 345 350

Asp Gly Ala Glu Ser Val Ile Arg Pro Thr Ser Ala Gly Trp Arg Leu 355 360 365 Cys Val Leu Ser Ser Tyr Thr Ser Arg Leu Phe Ala Thr Ser Cys Pro 370 375 380

Ala Val Ala Arg Ala Val Ala Arg Ala Ser Ser Ser Asp Tyr Lys 385 390 395

(2) INFORMATION FOR SEQ ID NO: 36:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 452 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 36:

Phe Leu Thr Gly Tyr Phe Arg Val His Gly Ile Asp Lys Leu Asp Gin 1 5 10 15

Arg Ala Val Gin Asp Val Thr Arg Arg His Pro Val Arg Ala Arg Pro

20 25 30

Lys His Ala Ala Ser Gly Val Xaa Ser Gly Leu Arg Gin Gly Ala Leu 35 40 45 Val His Xaa Ala Val Ser Gly Gly Ala Leu Gly Ala Ser Asp Ala Glu 50 55 60

Ala Val Leu Ala Gly Leu Glu Pro Pro Gly Gly Gly Arg Phe Ala Thr 65 70 75 80

Pro Gly Gly Pro Arg Ala Ala Gly Asp Asp Val Leu Asn Asp Val Leu 85 90 95

Thr Leu Val Pro Gly Thr Ala Lys Pro Arg Ser Leu Val Glu Trp Leu

100 105 110

Asp Arg Gly Trp Glu Pro Leu Ala Gly Gly Asp Arg Pro Asp Trp Leu 115 120 125 Trp Ser Arg Arg Ser Ile Ser Val Val Leu Arg His His Tyr Gly Thr 130 135 140

Lys Gin Arg Phe Val Val Val Ser Tyr Lys Asn Ser Val Ala Trp Gly 145 150 155 160

Gly Arg Arg Trp Pro Leu Leu Ser Ser Tyr Leu Ala Thr Ala Leu Thr 165 170 175

Glu Ala Cys Ala Ala Glu Arg Val Val Arg Pro His Gin Leu Ser Pro

180 185 190

Ala Ala Gin Thr Ala Leu Leu Arg Arg Phe Pro Ala Leu Glu Gly Pro 195 200 205 Leu Arg His Pro Arg Pro Val Leu Gin Pro Phe Asp Ile Ala Ala Glu 210 215 220

Val Ala Phe Val Ala Arg Ile Gin Ile Ala Cys Leu Arg Ala Leu Gly 225 230 235 240

His Ser Ile Arg Ala Ala Leu Gin Gly Gly Pro Arg Ile Phe Gin Arg 245 250 255

Leu Arg Tyr Asp Phe Gly Pro His Gin Ser Glu Trp Leu Gly Glu Val

260 265 270

Thr Arg Arg Phe Pro Val Leu Leu Glu Asn Leu Met Arg Ala Leu Glu 275 280 285

Gly Thr Ala Pro Asp Ala Phe Phe His Thr Ala Tyr Ala Val Leu Ala

290 295 300

His Leu Gly Gly Gin Gly Gly Arg Gly Arg Arg Arg Arg Leu Val Pro 305 310 315 320

Leu Ser Asp Asp Ile Pro Ala Arg Phe Ala Asp Ser Asp Ala His Tyr

325 330 335

Ala Phe Asp Tyr Tyr Ser Thr Ser Gly Asp Thr Leu Arg Leu Thr Asn 340 345 350 Arg Pro Ile Ala Val Val Ile Asp Gly Asp Val Asn Gly Arg Glu Gin 355 360 365

Ser Lys Cys Arg Phe Met Glu Gly Ser Pro Ser Thr Ala Pro His Arg

370 375 380

Val Cys Glu Gin Tyr Leu Pro Gly Glu Ser Tyr Ala Tyr Leu Cys Leu 385 390 395 400

Gly Phe Asn Arg Arg Leu Cys Gly Leu Val Val Phe Pro Gly Gly Phe

405 410 415

Ala Phe Thr Ile Asn Thr Ala Ala Tyr Leu Ser Leu Ala Asp Pro Val 420 425 430 Ala Arg Ala Val Gly Leu Arg Phe Cys Arg Gly Ala Gly Thr Gly Pro 435 440 445

Gly Leu Val Arg 450

(2) INFORMATION FOR SEQ ID NO: 37:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26339 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 37:

GGGAGCGAGG TGAGGGAATG AGAGAAGAAA GGAGGAGGAT AGTAAGTGGG GAGATGAAGA 60

AGAAAATAGA CGCTGGGAAG GAGAATACGA CGAGGAGGGA GGAAGGAGAA GAGAGTCGGA 120

AAGCATAAGA GGTGGAAAGG AGGTGTGAGT AATTGAGCGG AGATGAGAGG ATAGGATAAG 180

GCGAGAGACG GAAGATAAGA AAGTGAAGGG AGTAAGGGTA AGGTGAGAGA GAGAAAGAGG 240 AGGATTATGT GATGGTTAGG GGAGAGAGAG GAATATGTGG AGAAATTGTG AGGAAGGAAA 300

AGAGAGAGAA GAGTGTGGGT ATAAAGGAGA TATGGATGGA ATAGAGTAAA TTGAAGAAGG 360

GAAGAGATGG TAAGAATGGA GTGAAGAGGA GGTAAAGAAT TTAGTAAAGG AGTGGTGATG 420

ATGGATAAAA AAGTGGAAAT GGGGTAAGAA AGAAGAGAGA GGAGGAGGAA AAAAAAAAAA 480 TAAAAAAAGG GCCTTGCCGC CGGCCCTGGC GTACGCGCTA TA AAGCCCA TGCGGTATTG 540

GATGAGTTCC CGCGCGCCCC GGAACTCCTC CACCGCCCAC GGGGCCAGGT CCGCGGCCGC 600

CGCGTCAAAC TCCGCCAGCA GGCGCCCCAG GGCGTCAAAG TTCATCTCCC AGGGCACCCT 660

GCGCACCACC TCATCCCGCA GCCGGGCGCA CAGGGCGGTG TGCTTGGTGA CGCGCGCGCC 720 CAGCTCCTCC ACGGCCTCCG CGCGCTCGGC GCCCTTGGCG CCCAGGACGC CCTGGTACCT 780

GGCGGAAAGG CGCTCGTAGG CCGGCTGGGC CCGCAGCCCC GACACCGTGT TGGTGGTGTC 840

CTGCAGGGCG CGCAGCTGCT CGTGCATGGC GCGGAACCCC TCGGGGGACT TCCAGGCGCC 900

CCCCCGGACG CGGCCAAAGC GACCCCAGAC CTCGTCCCAC TCCGCCTCGG CCTCCTCCAG 960

GGACCTCCGC AGGGCGTCGA CGCGGCGCCG AGTATCAAAG AGCGCCCCCA GGCGGCCGGC 1020 GTGCCGCGCC AGGGGGCCGG GGCCGTCGCC GCGGGCGGCG CTTAGCGGGT GCGTCTCGAA 1080

GGTGCGCTGG GCGTGCTCTA GCCAGATAAC CGCGGGCACG TCGAGCTCGC GCGTTTTCTC 1140

GGTCTGATCC AACAGAACCT CGACCTGGTC GGCGATCTCC GCCACCGAGC GCGCCTGGTC 1200

GAGCGTCTTG GCCACGGTCG CCGGGACGGC GACCACCTTC AGCATGGTCT TGAGGTTGGC 1260

CAGGCCCTCG GCCTCGATCT GGGCCCGGCG CTCGCGCGCG GCCAGCGCCT CCCGCAGGCC 1320 CGCCATGACC CGCTCGGTGG CCTCCGCGCG CTGCTGTTTG GCGCGCACCA CTGCGTCCTT 1380

GGTCTCGGCC GTGTCCTGCC GGGTCACGAA GGCGACATAC TCGGCGTACG CCGTGTTCTT 1440

CACGGGGCTC TGGTCCACGC GCTCCAACGC CGCCGCGCAC GCGACCAGCG CGTCCTCGCT 1500

GGGACACGGC AGGGTGACCC CGGTCCGGAC CAGCTCCGCG GTGGCCTCCG GGTCATTCCG 1560

GGCCGCGGAT ATCTGCTCCG CGGCGGCCGC CAGGTCCAGG GGCACGCCGC CGAGCGCCCG 1620 GTGCACGTCG GCCCGGATGG CGTCCAGGCG ATCGCGGAGC TCCACGTAGT CGGCGTAGCC 1680

ATGTTGGAAG AACGGCACGT ACCGGCGCAG GCCGGGCACG CTCGTCATGT CGTCCGCCAG 1740

GCGCCCCACG GCCTCGTGGT AGTCGATAAA CCCGTCGCCC GCCTGGGCCA TTTCCAGGAG 1800

CCCCTCCGCG ATGCGCAGCA GCCGCGCCAG GGGCTCGGCG TCGACCCGAA ACATGTCGGC 1860

GTAGGTTTCG GCGGCGGCGT GGAACGCCGC GCTCCAGCCG AGGCGGTGGA TGGCGGCGAG 1920 CGGGGGGAGC ATGGGGTGGC GCTGGTTCTC GGGGGTGTAG GGGTTAAACG CGAAGGCCGT 1980

ATCCAGGGCG AGGGTGACCG CCTCGGCGTT GGCCGCGAGC GCCTGCTCGG CGCGCTTGCG 2040

GAAGTCCCGG GGGTTGTAGC CGTGCGTGCC CGCCAGCGCC TGCAGGCGGC GCAGCTCGAC 2100

CACGTCGAAC TCGGCGCGGT TCTCGACGCG GTCCAGCGCC GCCTCGACGC CGGCGGCCCA 2160

GCGCTCGCTG CTGCCCCGGG CGCGCTGGGC CGCCATCTTC CCCGTCAGGT CGGCGACGGC 2220 GGCCTCAAGT TCCTCGGCGC GGCGTCGCGT GGCGCCGATG ACCTTGCCCA GCTCCTGCAG 2280

GGCGCGCCCG CTGGGGGAAT GGTCCCCGGC CGTCCCTTCG GCGTGCAGCA GGCCCCCGAA 2340

CCCAGCCTCG TGCCCCGCGA GGCTTTCCCG AGCAGCGGTG GTCGCGCGGG CCGCGGCATC 2400

GATGAGGGCG GCATGGTCCC CCTCCGGCTG GGCGCAGGCC CGGCGCGCAT GGAATACCAG 2460

GTCGGCGGCC GCCGACCCCA GGGTGGTGAG CTTGTCGATG GCCCCCCGCG CCTCCAGGGC 2520 CAGCCGAGTC GCCTTTACAT ACCCCGCGGC GCTATCGGCC AGCGCCGCGA GGAAGGACAG 2580

GGGCGAGGCC GGGTCGCGGG CGGCCGCGCC CAGGGCCGAC ACCGCGTCCG CCAGGGCGCC 2640

ATGCGCCCGC ACGGCCGCGT CCACCGTCGC CGCGGGACTT GCCGTCGCGA CGGCGGCGCT 2700

CCCGGCGTTG ATGGCGTTTG ACACGGCTTT GGCGATTGTG GGGGCGTGAT CGGAAAAGAA 2760

CTGCACGAGG ACCGGCGTCT CGGGGGCGTC NGCGAACATG GTCTTCAGCA CCACCACTAA 2820 GGCGGGATGC ATGCCGGCCA CAACCGTCTC GGTATCCGGG GTCTGGTGTT CCANGGCCTC 2880

CCGGTACTGC CCCATCACCC CCCACATGTC CGCCCGCAGC CCCGCCTTGA CTTCCGGGGG 2940

GGGGCCCCCG GACGGCATCG GCCAGGTCGG TCCACCCCGC GGGGCAGGGA GGCCCGCAGG 3000

GTCGCCAGCA CGGCCGGACA CGCCTTTAGC CCCACAAAGT CCGGGAGGGG CCGCAGGACC 3060 CCTTGGAGTT TGTGCAGGAA CTTCTCCCGG GCGTCGTGGG CCACCTTGGC GCGCTCCCGC 3120

GCGTCGTTGA GCATCGCCTC CAGGGCGTGG GCGCGCTCCC GAAGCCGGGA GCGCGCCTCC 3180

GGAGCGAGCT CCGCCGTCAT CTTGGCCGCC TCCATGGCCC TCGCCTGCCG CAGCGCGTCT 3240

TCGGCCATGC GCGTGGCCTC GGGGGACAGC CCGCCCCCGT CGACGTACGG CGCGGGGCCG 3300 GTCGCCGGGA CGAAGGCCGC GTCGCTGTCC AGCTGCTGCG CGAGCGCCGC GTCGAGGGCG 3360

TCGAAGCGCT GCAGTTCGGC CAGCCCCGAG CTGCGCCGCG CCTGCTGGTC GTTGATGCCG 3420

TGGATGCTGC GCGCCAGCTC TTCCAGGGGC TTGCGTTCGA TGAGCCCCTG GGTCGCGGCG 3480

TCGGTCAGGA CCGAGAGCCA GGCCGCCAGG TCCTCGGGGG CATCTAGGGT CTGGCCCCGC 3540

TGGAGCAGGT CCCGCAGCAG GATGGCCTGG GGGCTGGTGG CGAGGGGGGG CGGGGGGGGG 3600 AGCGCGGCGC GCTGAGCGAC GTCCCGCGTG TGTTGGTCAA AGGCCGGTAG CGATTCCAGC 3660

AACTGGACCA TGGGCACGAC CGCGGCCGAG GCCACGTGAA ACCGACAGTC GTGGCTGTCG 3720

CTGGCCTGCA GGGCCTTCGC GCTGTATACG GCTCCCCGGT GGAAGTACTC CTTGATCGCG 3780

CTTTCGATCG CCCGGCGGGC CTGGATCCGC ACGTCCTCCA GCCGCGCATG GATGGCCTCG 3840

GGGCCCAGGG CGGGCGGGCA CGGGGCCCTG CCGCCGGCGC CCCGGGGGGG GGGGGCAACG 3900 GGCATCACGG TCAGGGGGCC CGGCGCGCTG CGAGACCGAG TAGACCCCGC GGGCGAGGGC 3960

GTATAAGGCC TCGCGCATCT CGCGGGCCTC CGCCTCGACC CGCATCTTTT TGCCCCGGGC 4020

AAAATGGGCC AGCGCCTGGA TCCGATGGAG AAGCGGCTCC GGGTGCGTCG GGGTGGCGGG 4080

GGCGAACAGG GTGTTCGGGT GGGCGCGCGA GCGCTCCAGG AGCCACTTTC CGAGGCGTGC 4140

GTACAGATTG GCCGGCGGGG CGGCGCGCAG CTGCAGATCC AGGTCCGCGA GGTCCCCGTA 4200 AAAGGCGTCC GTCTCCCGAA TAAAGTCCCT GGCGACCAGG ACCAGCTTAG CGAGGGCCAG 4260

GCGCCCGATC TGCGAATTTT TGTCCAGCAC GTGCTGGATG AGGGGCCGGT GGGCGGCCAC 4320

GTCCGCCAGG CTCATGCGCG TGGACGCCAG GAAGTCCCCG ACGGCCGTTT TGCGGGGCGG 4380

CATGCGCAGG GTGAAGTCCA GCAGGGCCGC GGCCGGGCCG GCCACCCCGG CCTGCGTATG 4440

CGTGCGGGCC CCGTTCTCGA TCAAAAAGGC GAGGACGCGC TCAAAGAAGA AGATGACGCA 4500 GAGCTCCAAC AGCCCCGGGT GCGCCGGGTA CGGCGACCGC AGGGCGTTGA TGGTGAGCTG 4560

CGAACACGCG GCCACCTCGC GGGCCAGGGC GGCATCGCGC GCCGCGAGCC GGACCGCCGT 4620

GGCGGCCACA TTGGGGTGGA CCTCGAACAG CTGCGCCAGG TCGGCGCCGG GGGGCTCCGG 4680

GGGGCGGCGG GCCCCCAGCG TCTCGAGCAC GGACGGCGAC GACGGGCTCG CGGGCCCGTC 4740

ATCGCCGCCT CCCTGCCCGG ACTGCGGGGG GGTATCCGGT GCGGGAGGGA CCGTGGCGGC 4800 TATGGGCGTC GGGGAGGAGG CGGGGACCTC GGCGGCGACG GGGGCCTTCT TCTTGGGCGC 4860

GGACTTCTTC TTGGCCTTGG CGGGCGGGGC CTTGGGGGCG GGCCTCTCGC CCGAGGTCAG 4920

ATCCTCCACG CTGGACGGTG GGGTCCAGGT GGGCCGGCGG CGCTTGGGCA AGCCGGTAGA 4980

ATAGCGCGCC CGGTGGCAAC CCACCGGCAC TGCCCCCACC TCCAGGACCC GCAGGTCCTC 5040

GGCTTCTTCG GCCGCGTCCC CGGCGGGTGT CTGCGGGGGC GGGGCGGCGT GCGGTGGACC 5100 CGAGGCCGCG GCGTCCGGGG CCGAGGGCTT TGCGGGCGGG GTCCCCTCCA GGGCTGCTGC 5160

CCACACATCA TCGGGGGGGC GGTTTGGGTG CCCCGCCTGC GGTGTGTTGG GTGGGCCCGA 5220

GGCCCCCCGG GGGGCCTCGG GGGGCCGGTC GGCCCGAGGG GTCTGGACGT GGGTGGGCGC 5280

GGGGAGCGCG GGGACGACCG GGCCCGAGCC TTCTCCGTCC CCCCTGGGGA CCACACCGAC 5340

AAAGAGCGCC CCTAGCCCCC CGATCTCGCC CCGCAGGGGG TGGGTGATGG CCACGCGCCG 5400 CTCGACGAAC GGTTCGTCCT GCAGGTAAGT CTCGCTGGCC CCGTAGAGGT GCAGGGCCGC 5460

GGCGGTCAGG TCCGCCGGCG CCACGGCCCC CGGGCCGGAG GGCACAAAAA ACACCATGGC 5520

GCCCGCCCAC CGCACCTTGG GGCGGTCGTG GGCGTAATAC GTCAGGTACG GGTACACGTC 5580

GCCCGCCCGC ACCTTGGCGA TAAACGCGGG CGTTCCCGCG GGCAGGCCGT GCGGGTCAAA 5640 CAGATAGGCC GTGTCGCCGT CCCGGTAGAG CCCCATGCCC AGGGGGCCGA TGGTCAGGAG 5700

CGTGTAGGAC AGCGGCCGCA TGGCCCAGGG GCCGGCGAAG AACGTGTGCG CGGGGCATTG 5760

CGTCTCCAGC AGCCCCGCCG TGGGCTCCCC GAAGAAGCCC ACCTCGCCGT ACACCCGCGA 5820

AAACACGCAA CGCAGGCCGC CGCGCGCCGC CGGGTACTCC AGGAAGTTGG GGAGCTCGAT 5880 AATGGAACAC ATGCGCGGCG GCCCGGAGCC CGCGGCCGCG CGCGTCCACT CGCCCCCCTC 5940

CACCAGACAT CCCTCAATGG CCTCCGCGGA CAGCACGTCG CGGGGCCCCA CGTCGAAAAG 6000

AAGACTGAGA AACGACAGGG ACGAGCGCAT GCACGATACC GACCCCCCCG GCTCCAGATC 6060

GGTCGCGAAC TGGTTCCGAA CACCGGTGAC CACGATATCG CGATCCCCCT GGGCGCTTCA 6120

TCGTGGGGTG AGGTAGCGCG GCCGGAATCA TGTGTGCCGC GCCCGCCACG AGCGGGGCCT 6180 GTTTATGGGC CGGGCGTCCC GATGAGTACT GTTGTTTCCG CCGCCCGAAC CCCCCCCGCC 6240

CATCAACCGC CTGTTCGTCC CCCTAACCAC ACACCCGGTA TCGCGTGAGC TCGTCGTAAC 6300

TGAACAGGAG CACGCGGGCG CAGGTCGCCC ACGGGCCCCA CGCCAGGCGC AGCGCCGCAA 6360

CCGTGTACGG GTCGTACACG CCTTGGGCGT CGCACGCGAC CGGCAGGGAG ACGAACAGCC 6420

CGCCCGCGCT GGGGACGCGC GGCAGGAGGT CCGGGTGCGC CGGGATGACG GGGGCTAGGA 6480 TCGCCCCCAC CGCATCCGCC GGCACGTAGG CGGCAAACGC CGAACGCCAC GGGGTGCAGT 6540

CGCCGGGCGC GTGGGGCCGG GTCTGGGTTT CGACCCGGAA GTTCGCGGCC GCCCCGCCGT 6600

CGGGGCGGCC GCGCACGAGG GCGGACAGCG GGACCCCCGC CGCCGCCAGG CACTCGCTGG 6660

AGATGATGAC GTGAATCAGC GAGGCGGGGC TGCTCGGGTC CCGGGTGAGA TCGTATTGGA 6720

CCTCGTTGGC AAAGTGCGCG TTCATGGCCC GGCCGGCGGT GCGAGCCCTT CCCGGTGCCG 6780 GAAGGGGCGT GGGTGGGGGG TGCGTGTGCG CGTCCTCGGG GCCCGCGGGC GCACGTGCGC 6840

TTATACGCTG TGTGTTTCGT CTGTCCCCAG GGAATCCGGG GCCAGGACTT TAACCTGCTT 6900

TTCGTCGACG AGGCCAACTT TATTCGCCCG GATGCGGTCC AGACGATTAT GGGCTTTCTC 6960

AATCAGGCCA ACTGCAAGAT CATCTTCGTC TCGTCGACCA ACACCGGGAA GGCCAGCACG 7020

AGCTTTTTGT ACAACCTCCG CGGGGCCGCC GACGAGCTGC TCAACGTGGT CACCTATATA 7080 TGCGACGACC ACATGCCGCG GGTGGTGACG CACACCAACG CCACGGCCTG TTCCTGCTAT 7140

ATCCTGAACA AACCCGTGTT TATCACGATG GACGGCGCCG TTCGCCGGAC GGCCGATCTG 7200

TTTCTGCCCG ACTCCTTCAT GCAGGAGATC ATCGGGGGGC AGGCCCGCGA GACCGGCGAC 7260

GACCGGCCCG TCCTAACAAA GTCGGCGGGG GAGCGGTTTC TGCTGTACCG CCCCTCCACC 7320

ACCACCAACA GCGGCCTGAT GGCCCCCGAG CTGTACGTGT ACGTGGACCC GGCGTTCACG 7380 GCCAACACGC GCGCCTCCGG CACCGGCATC GCGGTCGTCG GGAGGTACCG CGACGATTTC 7440

ATTATCTTCG CCCTGGAGCA CTTTTTCCTC CGCGCGCTCA CGGGATCGGC CCCCGCGGAC 7500

ATCGCCCGCT GCGTCGTGCA CAGCCTCGCC CAGGTGCTGG CGCTGCACCC CGGGGCGTTT 7560

CGCAGCGTTC GCGTGGCGGT CGAGGGCAAC AGCAGCCAGG ACTCGGCCGT GGCCATCGCC 7620

ACACACGTGC ATACCGAGAT GCACCGCATC CTGGCCTCGG CGGGGGCCAA CGGCCCGGGG 7680 CCCGAGCTCC TCTTCTATCA CTGCGAGCCG CCCGGCGGCG CGGTATTGTA CCCCTTCTTT 7740

CTGCTCAACA AACAGAAGAC GCCCGCCTTC GAATACTTTA TCAAAAAGTT CAACTCCGGG 7800

GGCGTCATGG CGTCCCAGGA GCTCGTCTCC GTGACGGTGC GCCTGCAGAC CGACCCGGTC 7860

GAGTATCTGT CCGAGCAGCT CAACAACCTC ATCGAAACCG TCTCTCCCAA CACCGACGTC 7920

CGCATGTACT CCGGAAAACG CAACGGTGCC GCGGACGACC TCATGGTCGC GGTCATCATG 7980 GCCATTTACC TGGCGGCCCC GACCGGGATC CCCCCGGCCT TTTTTCCGAT CACGCGCACG 8040

TCTTGAGTCT TTCTTGCCGT TTCTTTTGTT TCTCTTTCTT TCCCCCCTCT CTCCGCAATA 8100

AACGCCTTCC CGGAACTGTG TTTTCCCCCC CTACAACAGT GTTGTCCGTT GGTTGGGTGG 8160

TTGGGGTGCG GGGGTGGGCG GGGGAAGCAA GAAAACGGTC GGCGAACACA ACATCGGGAA 8220 AACGGATTCC CGAACGTGCG TCTTCCCAGA TTCGACACAC ACCCCCCTTC TCCTTAAATA 8280

AACACAAACC ACACGCTCGT TGGTTGGTTA ATGCCGGCGC TTTATTTACG TCTTGTTTTT 8340

TTGCGTTTCC TCCGCGGGTC CCTTCCCAAC ACGCCTGCCC CCGCCTCAGG GGTAGCGGAT 8400

AACCGGGGCC ATGTCGCCGG ATTGCACAAC GGCGGCGCCG TCGAACGTAC ACACCCGAAC 8460 CGCCGGGGCC AGGGCCAGGA TGTCCCCGAG TTGGCCCGCG TGCGCCAGCC AGGCGACCAG 8520

CGCCTCGTAA AGCGGCAGCC TGCGCTCGCC GTCCTGCATC AGCATGGGGG CTTCGGGGTG 8580

GATGAGCTGG GCGGCTTCTC GCGTGACGCT CTGCATCTGC AGGAGCGCGT TCACGTATCC 8640

GTCCTGGGCG CTCAGCGCGA GCAGCCGGGG GATGAGCGTG AGGATGAGGG TGGTTCCTTC 8700

GGTTATGGAG TAGACCATGT TGAGGACGAG CGACCGCAGC TCGGTGTTTA CGGAGGCGAG 8760 TTGCTGGACG TCGGCCACGA GCGAGAGACG GGCCCCGTTG TAATACAGCA CGTTGAGGTC 8820

GGGGAGCTCC CCGGGCGTCC GGGGGTCGGG GTTGAGGTCC CGGATGCCCC GGGCGACCAG 8880

CCGCGCGACT ATCTCGCGGG CCAGGGGCGT TGGGAGCGGG ACCGGAAACC GCAGCGTGAG 8940

GTCCAGCGAC TCCAGGCGCA CGTCCGTCGC CTGGCCCTCG AAGACGGGCG GGACGAGGCT 9000

GACGGGATCC CCGTTGCAGA GGTCGACGGG GGAGGTGTTG CGGAGATTGA CGGTGCCGGC 9060 GTGCGTGAGC CCCAGGTCCA CGGGGCAGGC GACGATTCGC GTGGGCAGCA CCCGCGTGAT 9120

TACCGCGGGG AAGCGCCTGC GGTACGCCAG CAACAACCCC AACGTGTCGG GACTAACTCC 9180

TCCGGAGACG AACGATTCGT GCGCCACGTC CGCGAGCGCC AGCTGGCGGC GGATGGTCGG 9240

CAGAAAGACC ACTCGACCCT CGCACCGCTG CAGCGCCGCG GCATCGGGGC GCGAGATACC 9300

CGAGGGGATC GCGATGTCTG CTTCGAAACA ATCCGTGATC ATGGCGCCGG GCCGCGAGAC 9360 ACCGGAACGC GGGGGTGCGG GAGGGCCGGA AAGCGCAACG CAACCGGGAC GATGATGAAA 9420

CAGAGATGGG GGGCACCGAC CGTGTGGGAG AGGGGGCGGG GCAGGGCTCA GCAGCACGCA 9480

CGGGGAGGTC TGTCGTGCGC AGGAGCCCCA GGTGAGAATC AGTCCCCCGG AGCTCGGGTC 9540

TGGGTTTTAT TGGGACCTGC CCTCGGAATC GCGGCTCCCA GTCCAAGCCC CCCCGGGGGG 9600

GCGGGGACAG GGGGTGTGTG TGGGTAAAAG CAACGTCGGA AAATCAAACC CAATGCCCCA 9660 AACAGGAAAA AAAAAAAAGA CGGGCGGGTG GAGGGAAAGC TGGGGAAGAA GAAGCCAATT 9720

TTACAGAGAC AGGCCCTTTA GCGGGGAGGC GTCGTAGATG AGATACTGCG TAAAGTGGGT 9780

CTCTCGCGCG TGGGCCTCCC CATCGCGGGC GCTGCGTAGC AGGGCGGGGT CGCTGGCGCA 9840

GGTGATCGGG TAGGCTTCCT GAAACAGGCC GCACGGGTCT TCCACGAGCT CGCGGCACCC 9900

CGGCGGGCGC TTAAACTGCA CGTCGCTGGC AGCGGTGGCC GTGGATACCG CCGATCCCGT 9960 TTCCACGATA AGACGCTCCA GGCAGCGATG TTTGGCCGTG ATGTCGGCCG CGGTGAAGAA 10020

CTTGAAGCAG GGGCTGAGGA CGGGCGAGGC CCCGTTGAGG TGATAGGCCC CGTTGTACAG 10080

CAGGTCCCCG TACGAGAACC GCTGCGACGC CCACGGGTTG GCCGTGGCCG CGAAGGGCCG 10140

CGCCGGGTCG CTCTGGCCGT GGTCGTACAT GAGGGCTATG ACGTCCCCCT CCTTGTCCCC 10200

CGCGTACACG CCGCCGGCCG CGCGTCCCCG CGGGTTGCAG GGCCGGCGAA AGTAGTTGAT 10260 GTCCGTGGCC ACGGGGGTGG CGATGAACTC ACACACGGCA TCCTGCCCGT GGTCCATGCC 10320

GGCGCGCCGC GGCACCTGGG CGCAGCCAAA GACCGGGAGG GGCTGGGCCG GCCCCAGCCG 10380

GTTTCCCGCC ACGACCGCGT TGCGCAGGTA CACGGCGGCC GCGTTGTTTA GCAGCGGGGG 10440

GGCCCCGCGG CCGAGGTAAA AGTTTTGGGG GAGGTTGCCC ATGTCCGTAA CGGGGTTGCG 10500

GACGGTGGCC GTGGCCGCGA CGGCGGTGTA GCCCACACCC AGGTCCACGT TTCCGCGCGG 10560 CTGGGTGAGC GTGAAGCTGA CCCCCCCGCC CGTTTCGTGG CGGGCCACCT GGAGCTGGCC 10620

CAGAAAGTAC GCCTCCGACG CGCGCTCGGA AAACAGCACG TTTTCGGTCA CGAAGCGGTC 10680

CTGCCGCACG ACGGTGAACC CGAACCCGGG GTGGAGGCCC GTCTTGAGCT GGTGATACAG 10740

GGCCACGGGG CTCATCTTGA AGTACCCCGC CATGAGCGCG TAGGTCAGCG CGTTCTCCCC 10800 CGCCGCGCTC TCGCGGGCGT GCTGCACCAC GGGCTGGCGG ATGGAGGAGA AGTAGTTGGC 10860

CCCCAGGGCC GGGGGGACCA GGGGGACGTG GCGCGCCAGG TCGCGCAGGG CCGGGGGGAA 10920

GTTGGGCGCG TTGGCCACGT GGTCGGCGCC CGCAAACAGC GCGTGGACGG GCAGGACGTA 10980

GAAGTATTCG CCATTTTGGA TGGTGTGGTC CAGGTGCTGG GGGGCCATGA GCAGCACGCC 11040 GGCGTGCAGC GCCCCGTCAA AAATGCGCAT GTTGGCCGTC GACGCGGTGT TGGCGCCCGC 11100

GTCGGGCGCC GCGGAGCACA GCAGCGCCGT CGTGCGCTCG GCCATGTTGT GCGCCAGCAC 11160

CTGCAGCGTG AGCATGGCGG GCCCGTCAAC AACAACGCGC CCGTTGTGGA ACATGGCGTT 11220

GACCGTGTTG GCCACCAAAT TGGCGGGATG CAGCGGGTGG GCGGGGTCGG TCACGGGATC 11280

GCTCGGGCAC TCCTCGCCGG GGGCGATCTC CGGGACCACC ATGTTCTGCA GCGTGGCGTA 11340 CACGCGGTCG AAGCGGACCC CCGCGGTGCA GCAGCGCCCC CGCGAGAAGG CCGGCACCAG 11400

CACGTAATAG TAGATTTTGT GGTGGACGGT CCAGTCGGCC GGCCGGTGCG GCCGGTCGTC 11460

GGCGGCGTCG GCCGCGCGGG CCTGGGTGTT GTGCAGCAGC CGGCCGTCGT TGCGGTTAAA 11520

GTCGGCCGTC GCCACGTTGC ACGCCGCCGC GTAGACGGGC TCGTGTCCCC CCGCGTCAAT 11580

CCGGCAGTCT CGGTGGCGGT CCAGGGCCGC GTGTCGCATA AGGCCGTCGC AGTCCCACAC 11640 GAGGGGCGGC AGCAGCGCCG GGTCGCGCAT CAGGTGATTC AGCTCGGCCT GAGCCTGCCC 11700

GCCCAGCTCC GGGCCCGGCA GGGTAAAGTC GTCCACCAGC TGGGCCAGGG CCTCGACGTG 11760

GGCCACCAGG TCCCGATACA CGGCCATGCA CTCCTCGGGG AGGTCGCCCC CGAGGTAGGT 11820

CACGATGTAC GAGACCAGCG AGTAGTCGTT CACGAACGCC GCGCATCGCG TGTTGTTCCA 11880

GTAGCTGGTG ATGCACTGAG TCACGAGCCG CGCCAGGGCG CAGAACACGT GCTCGCTGCC 11940 GTGAATCGCG GCTTGCAGCA GGTAAAACAC CGCCGGGTAG CTGCGGTCCT CGAACGCCCC 12000

GCGGACGGCG GCTATGGTAG CCGGCGCCAT GGCGTGGCGG CCAACGCCGA GCTCCAGGCC 12060

CCGGGCGTCA CGAAACGCCA CCGGACACAG CGCCAGGGGC AGGTTGCCGT TGACCACGCG 12120

CCAGGTGGCC TGGATCGCCC CCGGACCGGC CGGGGGGACT TCGCCGCCGG GAAGCTCGAC 12180

GTCGGCCACG CCCGCGAAGA AGTCGAACGC GGGGTGCAGC TCCAGAGCCA GGTTGGCGTT 12240 GTCGGGCTGC ATGAACTGCT CCGCGGTCAT CTGGCACTCG GCGACCCACC GGACCCGGCC 12300

GTGGGCGAGG CGCTGCCGCC AGGCGTTCAG AAAACGCTGC TGCATGTCCG CGCCGGGGCC 12360

GGCCGGGGCC GCGACGTACG CCCCGTACGG ATTCGCGGCC TCGACGGGGT CGTGGTTCAC 12420

GCCCCCGACG GCCGCGTCGA TGTTCATGAG CGAAGGATGA CACACGGTCC CGACCGCGTT 12480

CTCCATGGAC AGCCGCAGAA CCTGGTGGTC CTTTCCCCAA AAAAACAGCT GCCGGGGAGG 12540 GAACGCGCGG GGCTCCGGGT GGCCGGGGGC GGGCACCAGG TCCCCGGCGT GCGCGGCGAA 12600

GCGCTCCATG GCCGGGTTGA ACAGCCCCAG GGGCAGGACG AACGTCAGGT CCATGGCGCC 12660

CACCAGGGGG TAGGGCACGT TGGTGGCGGC GTAGATGCGC TTCTCCAGGG CCTCCAGGAA 12720

GACCAGCCTG TCGCCTATGG CCACCAGATC CGCGCGCACG CGCGTTGTCT GGGGGGCGCT 12780

TTCGAGTTCA TCCAGCGTCT CCCGGTTCGC CTCGAGTTGC TCCTCCTGCA TCTCCAGCAG 12840 GTGGCGGCCC ACGTCGTCCA GGCTCCGCAC GGCCTTGCCC ATCACCAGCG CCGTGACGAG 12900

GTTGGCCCCG TTCAAGACCA TCTCGCCGTA GGTCACCGGC ACGTCGGCCT CGGTGTCCTC 12960

CACCTTCAGG AAGGACTGCA GGAGGCGCTG TTTGATGGCG GCGGTGGTGA CCAGCACCCC 13020

GTCGACCGGC CGCCCGCGCG TGTCGGCGTG CGTCAGGCGG GGCACGGCCA CGGACGGCTG 13080

CGTCGCCGTG GTCAGGTCCA CGAGCCAGGC CTCGATGGCC TCGCGGCGAT GGCCCGCCTT 13140 GCCCAGGAAG AAGCTCGTGT CGCAAAAGCT CCGCTTCAGC TCGGCGACCA GGGTCGCCCG 13200

GGCGACCCTG GTCGCCAGGC GCCCGTTGTC GAGATATCGT TGCATGGGCA ACAGCAGGGC 13260

CAGGGGAGGC GCCTTCTCCA ACAGCACGTG CAGCATCTGG TCGGCCGTGC CGCGCTCAAA 13320

CGCCCCCAGG ACGGCCTGGA CGTTGCGCGC GAGCTGCTGG ATGGCGCGCA GCTGGCGATG 13380 CAGGCTAATG CCCGTCCCGT CCAGGGCCTC CCCCGTGAGC AGGGCAATGG CCTCGGTGGC 13440

CAGGCTGAAG GCGGCGTTCA GGGCCCGGCG GTCGATGACC TTCGTCATGT AATTATGCAC 13500

GGGCTGCTCG ACGGGGTGCG GGCCGTCGCG GGCGATGAGG GGCTGGTGGA CCTCGAACTG 13560

, CACACGCCCT TCGTTCATGT AAGCCAGCTC CGGGAACTTG GTGCACACGC ACGCCACGGA 13620 CAGGCCGAGC TCCAGAAAGC GCACGAGCGA CAGGGTGTTG CAGTAGGACC CCAGCAGGGC 13680

GTCAAACTCT ACGTCATACA GGCTGTTTTC GTCGGAGCGC ACGCGGGCGA AAAAATCAAA 13740

GAGTCTGCGG TGGGACGCCA CCTCGATCGT ACTCAGGATG GAGCCGGTGG GCACCATGGC 13800

CGCGGCGTAC CGGTAACCCG GGGGGTCGCG GGCAGGAGCG GCCATTGGGT TCCTTGGGGG 13860

ATTCGCAGGC TCCATCAAGC CAAGCTCGGG AAGGCCAAGC CCCTCCCACA CAACGCCTCA 13 20 CCGCCGGCGG ACGCGACTAA CAACCCACGG GCCGCCAAAA ACCCCAAGGG GCAACCCGAC 13980

CAACAACAGG CGAGGGGAGG AAAGGCGTAA AGGGGGCGTT GGGAGGCAAA AAGAAAGAAA 14040

ACACCCAGAC GTAGGCCCGA GGACCGGCCG GCGTCCTCTG TCCCCGAGCA CCCACTGTGC 14100

CCAACAGGCA CGGGGGCGAG CTGCCCCTGC CTTATATACC CCCCCGCCAC ACCCCCGTTA 14160

GAACGCGACG GGTGCCTTCA AGATGGCCCT GGTCCAAAAG CGTGCTAGAA AAAAGTTGGT 14220 AAAGGCGGCA AAGCAGTCCG CCGCCGCCAC CCACATGGCG GCGCCGGCCG CGCAGGCGAT 14280

TCCCAGAGAA CGGGCGCGGA GGGGATCCGT GCGGGGCAGC AGCTGGCTGG CGGTGATCCA 14340

ATGGAAAAGC CCGTCGGGAC TGAACGTCTC ATGGGCGGCC GCCACCAGGG CGCACAGGGC 14400

CGCGCCGCCC ATGATCACGC ACAACCCCCA AAACACGGGT GGCGACAACG GCAGGCGATC 14460

CCGTTTGATG TTCACGTACA GGAGGAGCGC CCGTGCCAGC CACGTGACAT AGTAGGCGAG 14520 GACGGCGGCT ATAATACATG CCGGCGCCAC CGCCCGTCCG GTCCACCCGT AATACATGCC 14580

CGCGGCCACC AGCTCCAGCG GCTTGAGGAC CAGGAACGAC CAAGCAAACA TCACCACCCG 14640

CTTGGAAAAG ACCGGCTGGG TGTGGGGCGG AAGACGCGAG TAGGCCGAAC TGACAAAAAA 14700

ATCAGACGTG CCGTACGAGG ACAGCGAAAA CTGTTCATCG AGCGGCAGTT CGCCGTCCTC 14760

CCCGCCACAC GCGGCCTCGT ATACCAGCTC GCGATCCAAC AAAGGAACAT CATCCCGCAT 14820 TGTCATGGTC GGTGCGGGGA GCCGGCGAGG CAGCGAAACC GAAAGTAGTG CTGGCGGCGC 14880

GGGCCCGGGT CCGGACCCAA GCTTCAGGGA TGGGGGGCGG AGGCCAAAAT CAAACAAGCA 14940

CCGCGCGGGT TCTACACACA ACCCCCACCC GGGTAGTATC CGCGGATGCG AGTGCCTGGC 15000

GAAGTCACGT CCCAGCAGGA TATAAACCTC GGCCGTTGGG CCCGGAACCC CCGAAATTCA 15060

CACCCACGCC CTGACGCCCA AATCATGGGT GGATGTGGTT CGCGAGCCGC ACATCCGTGC 15120 GTCCGCCCTC CCCCGCGGGC TGATGACGTG GCGGTTAGTC AGTGGGAAGG CAGGGGGAAA 15180

GATGGGTTGG GGGAGGAAAC GAAAAAAACA CCCAGAGGGC CACGTCGGGA ATGCGCCCGG 15240

AGTTGTCCTT AAAAGGCCGG CCGTGCGTGA CGGAAGCCGT CGTTTGCCCA AGCACCGACG 15300

CCGCGATCCA CAGTGGGGGG AGTTCCTCCG TCCGGCCACA ACCCTACGCG CGGGCGGCAC 15360

GCGCGAGAGC AACCCACGGG TCCCGTTCGC GCCACCGCCA GCCCTTGCTC CCACCACCCT 15420 CCTCCCACCA CCCCACTATT CCCCCCCCCC CAAGTCCGCC CCGTGGCTCG CCGGCCATGG 15480

AGCTCACCTA TGCCACCACC CTGCACCACC GGGACGTTGT GTTTTACGTC ACGGCAGACA 15540

GAAACCGCGC CTACTTTGTG TGCGGGGGGT CCGTTTATTC CGTAGGGCGG CCTCGGGATT 15600

CTCAGCCGGG GGAAATTGCC AAGTTTGGCC TGGTGGTCCG GGGGACAGGC CCCAAAGACC 15660

GCATGGTCGC CAACTACGTA CGAAGCGAGC TCCGCCAGCG CGGCCTGCGG GAAGTGCGGC 15720 CCGTGGGGGA GGACGAGGTG TTCCTGGACA GCGTGTGTCT GCTAAACCCG AACGTGAGCT 15780

CCGAGCGAGA CGTGATTAAT ACCAACGACG TTGAAGTGCT GGACGAATGC CTGGCCGAAT 15840

ACTGCACCTC GCTGCAAACC AGCCCGGGGG TGCTGGTGAC CGGGGTGCGC GTGCGCGCGC 15900

GAGACAGGGT CATCGAGCTA TTTGAGCACC CGGCGATCGT CAACATTTCC TCGCGCTTCG 15960 CGTACACCCC CTCCCCCTAC GTATTCGCCC TGGCCCAGGC GCACCTCCCC CGGCTCCCGA 16020

GCTCGCTGGA GCCCCTGGTG AGCGGCCTGT TTGACGGCAT TCCCGCCCCG CGCCAGCCCC 16080

TGGACGCCCG CGACCGGCGC ACGGATGTTG TGATCACGGG CACCCGCGCC CCCAGACCGA 16140

TGGCCGGGAC CGGGGCCGGG GGCGCGGGGG CCAAGCGGGC CACCGTCAGC GAGTTCGTGC 16200 AAGTGAAGCA CATCGACCGT GTTGTGTCCC CGAGCGTCTC TTCCGCCCCC CCGCCGAGCG 16260

CCCCCGACGC GAGTCTGCCG CCCCCGGGGC TCCAGGAGGC CGCCCCGCCG GGCCCCCCGC 16320

TCAGGGAGCT GTGGTGGGTG TTCTACGCCG GCGACCGGGC GCTGGAGGAG CCCCACGCCG 16380

AGTCGGGATT GACGCGCGAG GAGGTCCGCG CCGTGCATGG GTTCCGGGAG CAGGCGTGGA 16440

AGCTGTTTGG GTCGGTGGGG GCTCCGCGGG CGTTTCTCGG GGCCGCGCTG GCCCTGAGCC 16500 CGACCCAAAA GCTCGCCGTC TACTACTATC TCATCCACCG GGAGCGGCGC ATGTCCCCCT 16560

TCCCCGCGCT CGTGCGGCTC GTCGGTCGGT ACATCCAGCG CCACGGCCTG TACGTTCCCG 16620

CGCCCGACGA ACCGACGTTG GCCGATGCCA TGAACGGGCT GTTCCGCGAC GCGCTGGCGG 16680

CCGGGACCGT GGCCGAGCAG CTCCTCATGT TCGACCTCCT CCCGCCCAAG GACGTGCCGG 16740

TGGGGAGCGA CGCGCGGGCC GACAGCGCCG CCCTGCTGCG CTTTGTGGAC TCGCAACGCC 16800 TGACCCCGGG GGGGTCCGTC TCGCCCGAGC ACGTCATGTA CCTCGGCGCG TTCCTGGGCG 16860

TGTTGTACGC CGGCCACGGA CGCCTGGCCG CGGCCACGCA TACCGCGCGC CTGACGGGCG 16920

TGACGTCCCT GGTCCTGACC GTGGGGGACG TCGACCGGAT GTCCGCGTTT GACCGCGGGC 16980

CGGCGGGGGC GGCTGGCCGC ACGCGAACCG CCGGGTACCT GGACGCGCTG CTTACCGTTT 17040

GCCTGGCTCG CGCCCAGCAC GGCCAGTCTG TGTGAGATAT CCCAATAAAG TGCAGTCGTT 17100 TTCTAACCCA CGGATGCCGT TGTATGCCTA TACGGGGGAC TATGGGGGGG GGGGGAAAGG 17160

AAAGGAAACA GGAATGGAGA AGGGAAAGGA ACAGAGGCGG TAGCGGACGC ACGGCGGACA 17220

CAATAACAAA CAGACCGCGG ACACGGAGGG AGTCGGTTGG GTTGGGCGTG GACGCCGCTG 17280

CGTCCACACA CCCGTTTATT CGCGTCTCCA CAAAAATGGG ACGCACGTTC GGACCACCCT 17340

GAGGATGCCC GCCAGGGCCG CGGTGATCAT AACGACCCCC AGCGCGGACG CGGCCAGAAA 17400 CCCGGGGGCG ATGGTGGCGA TGGGCAGCGT GTCAAAGGCC AGCAGATGAA TCACAGTTCC 17460

GTTGGGGAAC AACAACAGGG CCACGGACGG CACGTCGCTG GAAAACACGT TCGGGGTGCC 17520

CGCCACCGGC CCCTGGGCCA GCTGCTGTTG GGTGGCATCC GTGTCCACCA GCAGCACCGA 17580

CATGACCTCC CCGGCCGGGG TGTAGCGCAG AAACACGGCC CCCACGAGGC CGAGGTCGCG 17640

CCGGTTTTCG GTGCGCACCA GCCGCTTCGG CTCAATCTCC CGCGCGTGCC CTTCGCAGGT 17700 GGCGGTGAGA TAGGTGATAA ACAGCGGGCG GCGGACGTCA ACGCCCGTAA GCTTGTATCC 17760

GATCCCGCGG GGCAAGGGGG TGTGGGTGAC GACGTAGCTG GCGTTGTGGG TGATGGGCAC 17820

GAGGATCCGG GGCTCCGCGT TGTGCGACGG GCCGCTACAC TGGTGGGTGG CCTCCGGGAC 17880

GAAGGCGCGG ATCAGGGCGT TGTAGTGCGC CCAGCGCGTG AGAACGGAGG CCACGCCGCG 17940

GGTCTGTTGT GCCATGACGT CCGCCGGGAT GTCGGATCGG GTGGCCATGG CCAGCGCGTC 18000 CAGGATGAAC CCGCCCTCGG CGAGATCGAA GCGCAGGGAA GCTGCGCATG GGGAAAAGTG 18060

GTCCGGGAGC CAGAAGAGGT TTTTCTGGTG GTCGGTCCTG GCTAGCGCGG CCCGGAGATC 18120

GGCGTGGGTC GCCGCGGCGA CGTCGGACGT ACACAGGGCC GTGGTTATGA GGAGGCCCCG 18180

GCGGGCGCGT TCCCGCTGCT CGGCCGAGGG CGCGCCCGCC AGGAACGGCG CCCGGAGGAC 18240

GGCCGTGGCG TAAAACAGCG CTCGGCGGAC CATCGGGGCG GTTAGCGCGC GGCCGCCGAG 18300 AAACTCGGCG TACAGGGCGT CGATCAGGCG GGCCGCGCTC GGGGCCACCG CGCCATAGGC 18360

CGCGGGGCTG TCCAACACGA ACGCCAGCTG ATAGCCCAGC GCGTGCGCCG CCAGGCTCTG 18420

CTCTCGCTCG AGGATCGCGG CCACCAGATG CCCGAGGCGC GCCTCCAGCC GCAGGCGGGC 18480

CGCCGGGTCC AACACGGACA CGTTCAGGAA CACCGAGTCG GCCGCGCAGC CCGCTGCTCC 18540 CCGGGCGGCC AGGCCGGCCA GCACGCGCGA GTGGGCCAAA AAGCCCAGCA GGTCGGAGAG 18600

GCGAATCGCG TCGTGGGCGT GGGCCGCGTT GACGAACGCA AACCCCGACG AGGCGAGCAG 18660

CCCCGCGAGG CGCCAGAACA GGGACGGACG CGCGTCCGTG CCGGAGCCCG GGTCCTCCCC 18720

CAAAAACTCC GCATAGGCCC GCGACATATA CTGGGCGTAG TTCGTGCTCT CCTCGGGGTA 18780 GCCGGCCACC CGCCGGAGGG CGTCCAGCGC CGAGCCGTTG TCGGCGGGCG TCGGGGCCCC 18840

CAGGACAAAG ACGCGATACC TGGGGCCGGC CGGAGGCCCG GGGAGCACCG CGGGGGCGTT 18900

TTCGTCGGTC GGATTTCCGA CCCGAGCGAG GGTCTTGTCC GCAGGCACCA CTATGATCTC 18960

GGCCGGAGGG CTGTCCCGCA TCGATATCAC AACCCCCATG AAGCCCTTCC CGTATCGCGC 19020

GCGCACAAGC GCGGCGTCGC ACCCGAACGC CAGCCCGCCC GTCGTCCAAA CGCCCACGGG 19080 CCACTTCAAG GCCGACGGGG AGAGGTACAC TTACCGACCC GGAGTCCGTA GCAGGCCCCT 19140

GGCGGCCAGC CAGGTCACGG ATGCGTTGTG CAGATGCGCG ATGCTCAGGT TCGTCGTCGG 19200

ATGCCTCGGT GTCCCCGCGG GCGGCCCCGG GGGCGGCGCG TTGCGTCGGC CGTCCGGGTG 19260

CCTCTCGGTC GCCCCGTCGT CTCCCCGCGG GAACGTAAGC CCCTCGCGGT CCGGCGCGGC 19320

CGCGAATGTT ACCCAGGCCC GGGACCGCAA CAGCGCGGAG GCGCCGGGGT TGTGCGACAG 19380 TCCCTTGAGC TGGGTCACCT CGGCGGGGGG ACGGGACGTG GGCCCCGCCT CGGGGAGCTC 19440

GGGCAGGCTC GCGTTCCGAG GCCGGCCGAG CAGATAGGTC TTTGGGATGT AAAGCAGCTG 19500

CCCGGGGTCC CGAGGAAACT CGGCCGTGGT GACCAACACA AAACAAAAGC GCTCGGCGTA 19560

CCACCGAAGC ATGGGCACGG ATGCCGTAGT CAGGTTGAGT TCGCCCGGGG GCGCCAAGCG 19620

TCCGCGCTGG GGGTCGCTGG CGTCGGGGGT GTTGGGCAAC CACAGACGCC CGGTGTTTGT 19680 GTCGCGCCAG TACGTGCGGG CCAACCCCAG ACCGTGCAAA AACCACGGGT CGATTTGCTC 19740

CGTCCAGTAC GTGTCATGGC CCCCGGCAAC GCCCACCAGG ACCCCCATCA CCACCCACAG 19800

ACCGGGGCCC ATGGTCGTCC GTCCCGGCTG CCAGTCCGCA GATGGGGGGG TGTCCGTACC 19860

CACGGCCCAA AGAGGCTCCG CACCTCGGAG GCTATCGGAG GCCCTTTGTT GCCGTAAGCG 19920

CGGGCCAAAG GATGGGGTGG GGTGAGGGTA AAAGCACAAA GGGAGTACCA GACCGAAAAC 19980 AAGGACGGAT CGGCCCGCTC CGTTTTTCGG TGGGGTGCTG ATACGGTGCC AGCCCTGGCC 20040

CCGAACCCCC GCGCTTATGG ACACACCACA CGACAACAAT GCCTTTTATT CTGTTCTTTT 20100

ATTGCCGTCA TCGCCGGGAG GCCTTCCGTT CGGGCTTCCG TGTTTGAACT AAACTCCCCC 20160

CACCTCGCGG GCAAACGTGC GCGCCAGGTC GCGTATCTCG GCGATGGACC CGGCGGTTGT 20220

GACGCGGGTT GGGATCATCC CGGCGGTGAG GCGCAACAGG GCGTCTCGAC ACCCGACGGG 20280 CGACTGATCG TAATCCAGGA CAAATAGATG CATCGGAAGG AGGCGGTCGG CCAAGACGTC 20340

CAAGACCCAG GCAAAAATGT GGTACAAGTC CCCGTTGGGG GCCAGCAGCT CGGGAACGCG 20400

GAACAGGGCA AACAGCGTGT CCTCGATGCG GGGCAGAGAC CCCGCGCCGT CCTCGGGGTC 20460

GGGGCGCGGG GTCGCCGCGG CGACCCCCGT CAGCCGGCCC CAGTCCTCCC GCCACCTCCC 20520

GCCGCGCTGC AGGTACCGCA CCGTGTTGGC GAGTAGATCG TAGACACGGC GAATGGCGGA 20580 CAGCATGGCC AGGTCAAGCC GCTCGCCCGG GCGTTGGCGT CTGGCCAGGC GGTCGGCGTG 20640

TTCGGCCTCC GGAAGGACAC CCAGGACCAG GTTCGTGCCG GGCGCGGTCG GGGGCATGAG 20700

GGCCACGAAC GCCAACACGG CCTGGGGGGT CATGCTTCCC ATGAGGTACC GCGCGGCCGG 20760

GTAGCACAGC AGGGAGGCGA TAGGGTGCCG GTCGAAAACA AGGGTGAGGG CCGGGGGCGG 20820

GGCTTGCGGG CCCACAGCCT CCCCCCCGAT ATGAGGAGCC AAAACGGCGT CCGTCGCCGC 20880 ATAAGGCGTG CTCATTGTTA TCTGGGCGCT GGTCATTACC ACCGCCGCCT CCCCGGCCGA 20940

TATCTCGCCG CGGTCCAGAC GGTGCTGCGT GTTGTAGATG TTCGTCAGGG TCTCGGAGGC 21000

CCCCAGCACC TGCCAGTAAG TCATCGGCTC GGGGACGTAG ACGATATTGT CGCGCGGCCC 21060

CAGGGCCTCC ATCAGCTGCG CGGAGGTGGT GGTCTTCCCC ACCCCGTGGG GTCCGTCTAT 21120 ATAAACCCGC AGCAGCGTGG GCAGCTCCGG ATCCCCGCGG GCTTCGGAGG CCCCCTGGCG 21180

ATGGCTAGGA CGGGACGCCG CGCGGCCGTC GGTAGGCCCG CTCGCACGAG CAGCCTGACC 21240

GAACGCAGGC GCGTGCTGTT GGCCGGCGTG AGAAGCCATA CCCGCTTCTA CAAGGCGTTC 21300

GCCCGAGAGG TGCGGGAGTT CAACGCCACC AGGATTTGTG GAACGCTGCT GACGCTGATG 21360 AGCGGGTCGC TGCAGGGTCG CTCGCTGTTC GAGGCCACGC GCGTCACCTT AATATGCGAA 21420

GTGGACCTCG GGCCGCGCCG CCCAGACTGC ATCTGCGTGT TCGAATTCGC CAATGACAAA 21480

ACGTTGGGAG GTGTGTGCGT CATCCTGGAG CTAAAGACAT GCAAATCGAT TTCTTCCGGG 21540

GACACGGCCA GCAAACGCGA ACAGCGGACC ACGGGCATGA AGCAGCTGCG CCACTCCCTG 21600

AAGCTGCTGC AGTCGCTCGC GCCTCCGGGG GACAAGGTCG TCTACCTGTG TCCTATTTTG 21660 GTGTTTGTCG CGCAGCGTAC GCTGCGCGTC AGCCGCGTGA CCCGGCTCGT CCCGCAAAAG 21720

ATCTCCGGCA ACATCACCGC GGCCGTGCGG ATGCTCCAAA GCCTGTCCAC GTATGCCGTG 21780

CCGCCGGAAC CGCAGACCCG GCGGTCGCGG CGCCGGGTTG CCGCGACCGC CAGACCGCAA 21840

AGGCCCCCCT CCCCGACACG TGACCCGGAA GGCACGGCGG GTCATCCGGC CCCACCAGAG 21900

AGCGACCCCC CCTCCCCAGG GGTTGTAGGC GTCGCTGCGG AGGGTGGGGG TGTGCTTCAG 21960 AAAATCGCGG CGCTTTTTTG CGTGCCGGTG GCCGCCAAGA GCAGACCCCG GACCAAAACC 22020

GAGTGAGGTT CTGTGTGTTG TTTTTTTTCC TCGTTTTGTT TTCTCTTCTT TCCCCCCCCC 22080

CTCCCCCGCT TCTGGCCAAG CATCCTCACC TGCTTAAGCG GAACCCGCGG GCGCGCGGGG 22140

ACTCATTTGT CGCCGGCGAC ACCCACCCGA CAACAGCCCC TGGGTGTAGA CCGCTGTCGC 22200

CCCCGTCTGT CGCCTCTCCC TTTTTTCCCC CCCTCAAAAA ACGTGGTGTT GGGCGCCGGC 22260 CAATTCTTCC CGGAGCGCCG TCGTCGCCCG CCCGCCGCCC TCGAACATGG ACCCGTACTA 22320

CCCTTTCGAC GCGCTGGACG TTTGGGAACA CAGGCGCTTC ATCGTCGCCG ACTCCAGGAG 22380

CTTCATCACC CCCGAGTTCC CCCGGGACTT CTGGATGTTG CCCGTGTTCA ACATCCCCCG 22440

GGAGACGGCG GCGGAGCGGG CGGCAGTGAT GCAGGCCCAG CGCACCGCGG CCGCGGCGGC 22500

CCTGGAGAAC GCCGCCCTCC AGGCCGCCGA GCTGCCCGTC GACATCGAGC GCCGGATACG 22560 CCCGATCGAG CAGCAGGTGC ATCACATCGC CGACGCCCTG GAGGCGCTGG AGACCGCGGC 22620

GGCCGCGGCC GAAGAGGCGG ATGCCGCGCG GGACGCCGAG GCGAGGGGGG AGGGCGCTGC 22680

GGACGGGGCA GCGCCGTCGC CCACCGCGGG CCCCGCCGCC GCGGAGATGG AGGTTCAGAT 22740

CGTACGCAAC GACCCGCCGC TACGATACGA TACCAACCTC CCCGTGGATC TGCTACACAT 22800

GGTGTACGCG GGCCGCGGGG CCGCGGGTTC GTCGGGAGTC GTCTTTGGTA CCTGGTACCG 22860 CACGATCCAG GAACGCACCA TCGCGGACTT CCCCCTGACC ACCCGCAGCG CCGACTTTCG 22920

AGACGGGCGC ATGTCCAAAA CCTTCATGAC CGCGCTGGTC CTGTCTCTGC AGTCGTGCGG 22980

CCGGCTGTAC GTGGGCCAGC GCCACTATTC CGCCTTCGAG TGCGCCGTGC TGTGTCTGTA 23040

TCTGCTGTAC CGAACCACCC ACGAGTCCTC CCCCGATCGC GATCGCGCTC CCGTTGCGTT 23100

CGGGGACCTG CTGGCCCGCC TGCCGCGCTA CCTGGCGCGT CTGGCCGCGG TAATCGGCGA 23160 CGAGAGCGGA CGCCCGCAGT ACCGCTACCG CGACGACAAG CTGCCCAAAG CGCAGTTCGC 23220

GGCGGCCGGC GGCCGCTACG AGCACGGGGC CCTGGCCACC CACGTCGTGA TCGCCACGTT 23280

GGTGCGCCAC GGGGTGCTAC CGGCGGCCCC GGGCGACGTT CCCCGAGACA CCAGCACCCG 23340

CGTGAACCCC GACGACGTGG CCCACCGCGA CGACGTCAAC CGCGCCGCCG CCGCGTTTTT 23400

GGCACGCGGC CACAACCTCT TCCTGTGGGA GGACCAGACG CTGCTGCGGG CGACCGCCAA 23460 CACCATTACG GCCCTGGCCG TGCTTCGGCG GCTCCTCGCG AACGGCAACG TGTACGCGGA 23520

CCGCCTCGAC AACCGCCTGC AGCTGGGCAT GCTGATCCCG GGAGCCGTCC CGGCGGAGGC 23580

CATCGCTCGG GGGGCGTCCG GATTGGACTC GGGCGCCATA AAAAGCGGCG ACAACAACCT 23640

GGAGGCGCTG TGCGTTAACT ATGTACTTCC GCTGTATCAG GCAGACCCCA CGGTCGAGCT 23700 GACCCAGTTG TTTCCGGGGG CTGGCCGCCC TGTGCCTGGA CGCCCAGGCG GGGCGGCCAC 23760

TGGCGTTGAC GAGGCGCGTG GTGGATATGT TGTCGGGCGC CCGCCAGGCG GCGCTCGTGC 23820

GCCTCACCGC GCTGGAGCTC ATCAACCGCA CCCGCACAAA CACCACCCCT GTGGGGGAGA 23880

TTATTAACGC CCACGATGCC TTGGGGATAC AATACGAACA GGGCCTGGGG CTGCTCGCCC 23940 AGCAGGCACG CATCGGCTTG GCGTCGAACG CCAAGCGATT CGCCACGTTC AACGTGGGCA 24000

GCGACTACGA CCTGTTGTAC TTTTTGTGTC TCGGGTTCAT TCCCCAGTAC CTGTCCGTGG 24060

CCTAGGGAAG GGTGGGGGTG GTGGTGGTGG GGTGTTTTTC TGCTGTTGTT GTTTCTGGTC 24120

CGCCTGGTCA CAAAAGGCAC GGCGCCCCGA AACGCGGGCT TTAGTCCCGG CCCGGACGTC 24180

GGCGGACACA CAACAACGGC GGGCCCCGTG GGTGGGTAAG TTGGTTCGGG GGCATCGCTG 24240 TATTCCCTTG CCCGCTTCCA CCCCCCCTTC CCGTTTTGTT TGTTTGTGCG GGTGCCCATG 24300

GCGTCGGCGG AAATGCGCGA GCGGTTGGAG GCGCCTCTGC CCGACCGGGC GGTGCCCATC 24360

TACGTGGCCG GGTTTTTGGC CCTGTACGAC AGCGGGGACC CGGGCGAGCT GGCCCTGGAC 24420

CCAGACACGG TGCGTGCGGC CCTGCCTCCG GAGAACCCCC TGCCGATCAA CGTAGACCAC 24480

CGCGCTCGGT GCGAGGTGGG CCGGGTGCTC GCCGTGGTCA ACGACCCTCG GGGGCCGTTT 24540 TTTGTGGGGC TGATCGCGTG CGTGCAGCTG GAGCGCGTCC TCGAGACGGC CGCCAGCGCC 24600

GCTATTTTTG AGCGCCGCGG ACCCGCGCTC TCCCGGGAGG AGCGTCTGCT GTACCTGATC 24660

ACCAACTACC TGCCATCGGT CTCGCTGTCC ACAAAACGCC GGGGGGACGA GGTTCCGCCC 24720

GACCGCACCC TGTTTGCGCA CGTGGCCCTG TGCGCCATCG GGCGGCGCCT TGGAACCATC 24780

GTCACCTACG ACACCAGCCT AGACGCGGCC ATCGCTCCGT TTCGCCACCT GGACCCGGCG 24840 ACGCGCGAGG GGGTGCGACG CGAGGCCGCC GAGGCCGAGC TCGCGCTGGC CGGGCGCACC 24900

TGGGCCCCCG GCGTGGAGGC GCTCACACAC ACGCTGCTCT CCACCGCCGT CAACAACATG 24960

ATGCTGCGTG ACCGCTGGAG CCTCGTGGCC GAGCGGCGGC GGCAGGCCGG GATCGCCGGA 25020

CACACGTACC TTCAGGCGAG CGAAAAATTT AAAATATGGG GGGCGGAGTC TGCCCCTGCG 25080

CCGGAGCGCG GGTATAAAAC CGGCGCCCCG GGTGCCATGG ACACATCCCC CGCCGCGAGC 25140 GTTCCCGCGC CGCAGGTCGC CGTCCGTGCG CGTCAAGTCG CGTCGTCGTC GTCTTCTTCT 25200

TCTTCTTTTC CGGCACCGGC CGATATGAAC CCCGTTTCGG CATCGGGCGC CCCGGCCCCT 25260

CCGCCGCCCG GCGACGGGAG TTATTTGTGG ATCCCCGCCT TTCATTACAA TCAGCTCGTC 25320

ACCGGGCAAT CCGCGCCCCA CCACCCGCCG CTGACCGCGT GCGGCCTGCC GGCCGCGGGG 25380

ACGGTGGCCT ACGGACACCC CGGCGCCGGC CCGTCCCCGC ACTACCCGCC TCCTCCCGCC 25440 CACCCGTACC CGGGGTATGC TGTTCGCGGG CCCCAGTCCC CTGGAGGCCC AGATCGCCGC 25500

GCTGGTGGGG GCCATCGCCG CCGACCGCCA GGCGGGTGGG CTTCCGGCGG CCGCCGGAGA 25560

CCACGGGATC CGGGGGTCGG CGAACCGCCG CCGACACGAG GTGGAGCAGC CGGAGTACGA 25620

CTGCGGCCGT GACGAGCCGG ACCGGGACTT CCCGTATTAC CCGGGCGAGG CCCGCCCCGA 25680

GCCGCGCCCG GTCGACTCCC GGCGCGCCGC GCGCCAGGCT TCCGGGCCCC ACGAAACCAT 25740 CACGGCGCTG GTGGGGGCGG TGACGTCCCT GCAGCAGGAA CTGGCGCACA TGCGCGCGCG 25800

TACCCACGCC CCCTACGGGC CGTATCCGCC GGTGGGGCCC TACCACCACC CCCACGCAGA 25860

CACGGAGACC CCCGCCCAAC CACCCCGCTA CCCCGCCGAG GCCGTCTATC TGCCGCCGCC 25920

GCACATCGCC CCCCCGGGGC CTCCTCTATC CGGGGCGGTC CCCCCACCCT CGTATCCCCC 25980

AGTTGCGGTT ACCCCCGGTC CCGCCCCCCC GCTACATCAG CCCTCCCCCG CACACGCCCA 26040 CCCCCCTCCG CCGCCGCCGG GACCCACGCC TCCCCCCGCC GCGAGCTTAC CCCAACCCGA 26100

GGCGCCCGGC GCGGAGGCCG GCGCCTTAGT TAACGCCAGC AGCGCGGCCC ACGTGAACGT 26160

GGACACGGCC CGGGCCGCCG ATTTGTTTGT GTCACAGATG ATGGGGTCCC GCTAACTCGC 26220

CTCCAGGATC CGGACTTGGG GGGGGTGTGT GTTTTCATAT ATTTTAAATA AACAAACAAC 26280 CGGACAAAAG TATACCCACT TCGTGTGCTT GTGTTTTTGT TTGAGAGGGG GGGGGTGG 26339

(2) INFORMATION FOR SEQ ID NO: 38:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 897 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 38:

Val Ser Gly Arg Ala Gly Asp Pro Ala Gly Leu Pro Ala Pro Arg Gly 1 5 10 15

Gly Pro Thr Trp Pro Met Pro Ser Gly Gly Pro Pro Pro Glu Val Lys

20 25 30

Ala Gly Leu Arg Ala Asp Met Trp Gly Val Met Gly Gin Tyr Arg Glu 35 40 45

Ala Xaa Glu His Gin Thr Pro Asp Thr Glu Thr Val Val Ala Gly Met

50 55 60

His Pro Ala Leu Val Val Val Leu Lys Thr Met Phe Xaa Asp Ala Pro 65 70 75 80 Glu Thr Pro Val Leu Val Gin Phe Phe Ser Asp His Ala Pro Thr Ile

85 90 95

Ala Lys Ala Val Ser Asn Ala Ile Asn Ala Gly Ser Ala Ala Val Ala

100 105 110

Thr Asp Ala Ala Thr Val Asp Ala Ala Val Arg Ala His Gly Ala Asp 115 120 125

Ala Val Ser Ala Leu Gly Ala Ala Ala Arg Asp Pro Asp Leu Ser Phe

130 135 140

Leu Ala Ala Asp Ser Ala Ala Gly Tyr Val Lys Ala Thr Arg Leu Ala 145 150 155 160 Leu Glu Arg Ala Ile Asp Lys Leu Thr Thr Leu Gly Ser Ala Ala Ala

165 170 175

Asp Leu Val Phe His Ala Arg Arg Ala Cys Ala Gin Pro Glu Gly Asp

180 185 190

His Ala Ala Leu Ile Asp Ala Ala Ala Arg Ala Thr Thr Ala Ala Arg 195 200 205

Glu Ser Leu Ala Gly His Glu Ala Gly Phe Gly Gly Leu Leu His Ala

210 215 220

Glu Gly Thr Ala Gly Asp His Ser Pro Ser Gly Arg Ala Leu Gin Glu 225 230 235 240

Leu Gly Lys Val Ile Gly Ala Thr Arg Arg Arg Ala Glu Glu Leu Glu

245 _ 250 255

Ala Ala Val Ala Asp Leu Thr Gly Lys Met Ala Ala Gin Arg Arg Ser 260 265 270

Ser Trp Ala Ala Gly Val Glu Ala Ala Leu Asp Arg Val Glu Asn Arg

275 280 285

Ala Glu Phe Asp Val Val Glu Leu Arg Arg Leu Gin Ala Gly Thr His

290 295 300 Gly Tyr Asn Pro Arg Asp Phe Arg Lys Arg Ala Glu Gin Ala Ala Asn

305 310 315 320

Ala Glu Ala Val Thr Leu Ala Leu Asp Thr Ala Phe Ala Phe Asn Pro

325 330 335

Tyr Thr Pro Glu Asn Gin Arg His Pro Met Leu Pro Pro Leu Ala Ala 340 345 350

Ile His Arg Leu Gly Trp Ser Ala Ala Phe His Ala Ala Ala Glu Thr

355 360 365

Tyr Ala Asp Met Phe Arg Val Asp Ala Glu Pro Leu Ala Arg Leu Leu

370 375 380 Arg Ile Ala Glu Gly Leu Leu Glu Met Ala Gin Ala Gly Asp Gly Phe

385 390 395 400

Ile Asp Tyr His Glu Ala Val Gly Arg Leu Ala Asp Asp Met Thr Ser

405 410 415

Val Pro Gly Leu Arg Arg Tyr Val Pro Phe Phe Gin His Gly Tyr Ala 420 425 430

Asp Tyr Val Glu Leu Arg Asp Arg Leu Asp Ala Ile Arg Ala Asp Val

435 440 445

His Arg Ala Leu Gly Gly Val Pro Leu Asp Leu Ala Ala Ala Ala Glu

450 455 460 Gin Ile Ser Ala Ala Arg Asn Asp Pro Glu Ala Thr Ala Glu Leu Val

465 470 475 480

Arg Thr Gly Val Thr Leu Pro Cys Pro Ser Glu Asp Ala Leu Val Ala

485 490 495

Cys Ala Ala Ala Leu Glu Arg Val Asp Gin Ser Pro Val Lys Asn Thr 500 505 510

Ala Tyr Ala Glu Tyr Val Ala Phe Val Thr Arg Gin Asp Thr Ala Glu

515 520 525

Thr Lys Asp Ala Val Val Arg Ala Lys Gin Gin Arg Ala Glu Ala Thr 530 535 540 Glu Arg Val Met Ala Gly Leu Arg Glu Ala Ala Arg Glu Arg Arg Ala 545 550 555 560

Gin Ile Glu Ala Glu Gly Leu Ala Asn Leu Lys Thr Met Leu Lys Val 565 570 575 Val Ala Val Pro Ala Thr Val Ala Lys Thr Leu Asp Gin Ala Arg Ser

580 585 590

Val Ala Glu Ile Ala Asp Gin Val Glu Val Leu Leu Asp Gin Thr Glu 595 600 605 Lys Thr Arg Glu Leu Asp Val Pro Ala Val Ile Trp Leu Glu His Ala 610 615 620

Gin Arg Thr Phe Glu Thr His Pro Leu Ser Ala Arg Asp Gly Pro Gly 625 630 635 640

Pro Leu Ala Arg His Ala Gly Arg Leu Gly Ala Leu Phe Asp Thr Arg 645 650 655

Arg Arg Val Asp Ala Leu Arg Arg Ser Leu Glu Glu Ala Glu Ala Glu

660 665 670

Trp Asp Glu Val Trp Gly Arg Phe Gly Arg Val Arg Gly Gly Ala Trp 675 680 685 Lys Ser Pro Glu Gly Phe Arg Ala Met His Glu Gin Leu Arg Ala Leu 690 695 700

Gin Asp Thr Thr Asn Thr Val Ser Gly Leu Arg Ala Gin Pro Ala Tyr 705 710 715 720

Glu Arg Leu Ser Ala Arg Tyr Gin Gly Val Leu Gly Ala Lys Gly Ala 725 730 735

Glu Arg Ala Glu Ala Val Glu Glu Leu Gly Ala Arg Val Thr Lys His

740 745 750

Thr Ala Leu Cys Ala Arg Leu Arg Asp Glu Val Val Arg Arg Val Pro 755 760 765 Trp Glu Met Asn Phe Asp Ala Leu Gly Arg Leu Leu Ala Glu Phe Asp 770 775 780

Ala Ala Ala Ala Asp Leu Ala Pro Trp Ala Val Glu Glu Phe Arg Gly 785 790 795 800

Ala Arg Glu Leu Ile Gin Tyr Arg Met Gly Ser Ala Tyr Ala Arg Ala 805 810 815

Gly Gly Lys Ala Leu Phe Leu Phe Phe Phe Phe Pro Pro Pro Leu Ser

820 825 830

Ser Phe Leu Pro His Phe His Phe Phe Ile His His His His Ser Phe 835 840 845 Thr Lys Phe Phe Thr Ser Ser Ser Leu His Ser Tyr His Leu Phe Pro 850 855 860

Ser Ser Ile Tyr Ser Ile Pro Ser Ile Ser Pro Leu Tyr Pro His Ser 865 870 875 880

Ser Leu Ser Phe Pro Ser Ser Gin Phe Leu His Ile Phe Leu Ser Leu 885 890 895

Pro ( 2 ) INFORMATION FOR SEQ ID NO : 39 :

( i ) SEQUENCE CHARACTERISTICS : (A) LENGTH : 335 amino acids ( B ) TYPE : amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 39:

Val Met Pro Val Ala Pro Pro Pro Arg Gly Ala Gly Gly Arg Ala Pro

1 5 10 15

Cys Pro Pro Ala Leu Gly Pro Glu Ala Ile His Ala Arg Leu Glu Asp 20 25 30

Val Arg Ile Gin Ala Arg Arg Ala Ile Glu Ser Ala Ile Lys Glu Tyr 35 40 45

Phe His Arg Gly Ala Val Tyr Ser Ala Lys Ala Leu Gin Ala Ser Asp 50 55 60

Ser His Asp Cys Arg Phe His Val Ala Ser Ala Ala Val Val Pro Met

65 70 75 80

Val Gin Leu Leu Glu Ser Leu Pro Ala Phe Asp Gin His Thr Arg Asp 85 90 95

Val Ala Gin Arg Ala Ala Leu Pro Pro Pro Pro Pro Leu Ala Thr Ser 100 105 110

Pro Gin Ala Ile Leu Leu Arg Asp Leu Leu Gin Arg Gly Gin Thr Leu

115 120 125

Asp Ala Pro Glu Asp Leu Ala Ala Trp Leu Ser Val Leu Thr Asp Ala 130 135 140

Ala Thr Gin Gly Leu Ile Glu Arg Lys Pro Leu Glu Glu Leu Ala Arg

145 150 155 160

Ser Ile His Gly Ile Asn Asp Gin Gin Ala Arg Arg Ser Ser Gly Leu 165 170 175

Ala Glu Leu Gin Arg Phe Asp Ala Leu Asp Ala Ala Gin Gin Leu Asp 180 185 190

Ser Asp Ala Ala Phe Val Pro Ala Thr Gly Pro Ala Pro Tyr Val Asp 195 200 205

Gly Gly Gly Leu Ser Pro Glu Ala Thr Arg Met Ala Glu Asp Ala Leu 210 215 220

Arg Gin Ala Arg Ala Met Glu Ala Ala Lys Met Thr Ala Glu Leu Ala

225 230 235 240

Pro Glu Ala Arg Ser Arg Leu Arg Glu Arg Ala His Ala Leu Glu Ala 245 250 255

Met Leu Asn Asp Ala Arg Glu Arg Ala Lys Val Ala His Asp Ala Arg

260 265 270

Glu Lys Phe Leu His Lys Leu Gin Gly Val Leu Arg Pro Leu Pro Asp 275 280 285

Phe Val Gly Leu Lys Ala Cys Pro Ala Val Leu Ala Thr Leu Arg Ala

290 295 300

Ser Leu Pro Arg Gly Val Asp Arg Pro Gly Arg Cys Arg Pro Gly Ala 305 310 315 320 Pro Pro Arg Lys Ser Arg Arg Gly Cys Gly Arg Thr Cys Gly Gly

325 330 335

(2) INFORMATION FOR SEQ ID NO: 40:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 800 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 40:

Val Val Thr Gly Val Arg Asn Gin Phe Ala Thr Asp Leu Glu Pro Gly 1 5 10 15

Gly Ser Val Ser Cys Met Arg Ser Ser Leu Ser Phe Leu Ser Leu Leu

20 25 30

Phe Asp Val Gly Pro Arg Asp Val Leu Ser Ala Glu Ala Ile Glu Gly 35 40 45

Cys Leu Val Glu Gly Gly Glu Trp Thr Arg Ala Ala Ala Gly Ser Gly

50 55 60

Pro Pro Arg Met Cys Ser Ile Ile Glu Leu Pro Asn Phe Leu Glu Tyr 65 70 75 80 Pro Ala Arg Gly Leu Arg Cys Val Phe Ser Arg Val Tyr Gly Glu Val

85 90 95

Gly Phe Phe Gly Glu Pro Thr Ala Gly Leu Leu Glu Thr Gin Cys Pro

100 105 110

Ala His Thr Phe Phe Ala Gly Pro Trp Ala Met Arg Pro Leu Ser Tyr 115 120 125

Thr Leu Leu Thr lie Gly Pro Leu Gly Met Gly Arg Asp Gly Asp Thr

130 135 140

Ala Tyr Leu Phe Asp Pro His Gly Leu Pro Ala Gly Thr Pro Ala Phe 145 150 155 160

Ile Ala Lys Val Arg Ala Gly Asp Val Tyr Pro Tyr Leu Thr Tyr Tyr

165 170 175

Ala His Asp Arg Pro Lys Val Arg Trp Ala Gly Ala Met Val Phe Phe 180 185 190

Val Pro Ser Gly Pro Gly Ala Val Ala Pro Ala Asp Leu Thr Ala Ala

195 200 205

Ala Leu His Leu Tyr Gly Ala Ser Glu Thr Tyr Leu Gin Asp Glu Pro

210 215 220 Phe Val Glu Arg Arg Val Ala Ile Thr His Pro Leu Arg Gly Glu Ile

225 230 235 240

Gly Gly Leu Gly Ala Leu Phe Val Gly Val Val Pro Arg Gly Asp Gly

245 250 255

Glu Gly Ser Gly Pro Val Val Pro Ala Leu Pro Ala Pro Thr His Val 260 265 270

Gin Thr Pro Arg Ala Asp Arg Pro Pro Glu Ala Pro Arg Gly Ala Ser

275 280 285

Gly Pro Pro Asn Thr Pro Gin Ala Gly His Pro Asn Arg Pro Pro Asp

290 295 300 Asp Val Trp Ala Ala Ala Leu Glu Gly Thr Pro Pro Ala Lys Pro Ser

305 310 315 320

Ala Pro Asp Ala Ala Ala Ser Gly Pro Pro His Ala Ala Pro Pro Pro

325 330 335

Gin Thr Pro Ala Gly Asp Ala Ala Glu Glu Ala Glu Asp Leu Arg Val 340 345 350

Leu Glu Val Gly Ala Val Pro Val Gly Cys His Arg Ala Arg Tyr Ser

355 360 365

Thr Gly Leu Pro Lys Arg Arg Arg Pro Thr Trp Thr Pro Pro Ser Ser

370 375 380 Val Glu Asp Leu Thr Ser Gly Glu Arg Pro Ala Pro Lys Ala Pro Pro

385 390 395 400

Ala Lys Ala Lys Lys Lys Ser Ala Pro Lys Lys Lys Ala Pro Val Ala

405 410 415

Ala Glu Val Pro Ala Ser Ser Pro Thr Pro Ile Ala Ala Thr Val Pro 420 425 430

Pro Ala Pro Asp Thr Pro Pro Gin Ser Gly Gin Gly Gly Gly Asp Asp

435 440 445

Gly Pro Asp Ser Ser Pro Ser Val Leu Glu Thr Leu Gly Ala Arg Arg 450 455 460 Pro Pro Glu Pro Pro Gly Ala Asp Leu Ala Gin Leu Phe Glu Val His 465 470 475 480

Pro Asn Val Ala Ala Thr Ala Val Arg Leu Ala Ala Arg Asp Ala Ala 485 490 495 Arg Glu Val Ala Ala Cys Ser Gin Leu Thr Ile Asn Ala Leu Arg Ser

500 505 510

Pro Tyr Pro Ala His Pro Gly Leu Leu Glu Leu Cys Val Ile Phe Phe 515 520 525 Phe Glu Arg Val Leu Ala Phe Leu Ile Glu Asn Gly Ala Arg Thr His 530 535 540

Thr Gin Ala Gly Val Ala Gly Pro Ala Ala Ala Leu Leu Asp Phe Thr 545 550 555 560

Leu Arg Met Pro Pro Arg Lys Thr Ala Val Gly Asp Phe Leu Ala Ser 565 570 575

Thr Arg Met Ser Leu Ala Asp Val Ala Ala His Arg Pro Leu Ile Gin

580 585 590

His Val Leu Asp Lys Asn Ser Gin Ile Gly Arg Leu Ala Lys Leu Val 595 600 605 Leu Val Ala Arg Asp Phe Ile Arg Glu Thr Asp Ala Phe Tyr Gly Asp 610 615 620

Leu Ala Asp Leu Asp Leu Gin Leu Arg Ala Ala Pro Pro Ala Asn Leu 625 630 635 640

Tyr Ala Arg Leu Gly Lys Trp Leu Leu Glu Arg Ser Arg Ala His Pro 645 650 655

Asn Thr Leu Phe Ala Pro Ala Thr Pro Thr His Pro Glu Pro Leu Leu

660 665 670

His Arg Ile Gin Ala His Phe Arg Lys Lys Met Arg Val Glu Ala Glu 675 680 685 Ala Arg Glu Met Arg Glu Ala Leu Tyr Arg Val Tyr Ser Val Ser Gin 690 695 700

Arg Ala Gly Pro Pro Asp Arg Asp Ala Arg Cys Pro Pro Pro Pro Gly 705 710 715 720

Arg Arg Arg Gin Gly Pro Val Pro Ala Arg Pro Gly Pro Arg Gly His 725 730 735

Pro Cys Ala Ala Gly Gly Arg Ala Asp Pro Gly Pro Pro Gly Asp Arg

740 745 750

Lys Arg Asp Gin Gly Val Leu Pro Pro Gly Ser Arg Ile Gin Arg Glu 755 760 765 Gly Pro Ala Gly Gin Arg Gin Pro Arg Leu Ser Val Ser Arg Gly Leu 770 775 780

Gly Arg Gly Arg Ala His Gly Pro Val Ala Gly Ile Ala Thr Gly Leu 785 790 795 800

(2) INFORMATION FOR SEQ ID NO: 41:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 158 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ,

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 41:

Met Asn Ala His Phe Ala Asn Glu Val Gin Tyr Asp Leu Thr Arg Asp 1 5 10 15

Pro Ser Ser Pro Ala Ser Leu Ile His Val Ile Ile Ser Ser Glu Cys

20 25 30

Leu Ala Ala Ala Gly Val Pro Leu Ser Ala Leu Val Arg Gly Arg Pro 35 40 45 Asp Gly Gly Ala Ala Ala Asn Phe Arg Val Glu Thr Gin Trp His Ala 50 55 60

Pro Gly Asp Cys Thr Pro Trp Arg Ser Ala Phe Ala Ala Tyr Val Pro 65 70 75 80

Ala Asp Ala Val Gly Ala Ile Leu Ala Pro Val Ile Pro Ala His Pro 85 90 95

Asp Leu Leu Pro Arg Val Pro Ser Ala Gly Gly Leu Phe Val Ser Leu

100 105 110

Pro Val Ala Cys Asp Ala Gin Gly Val Tyr Asp Pro Tyr Thr Val Ala 115 120 125 Ala Leu Arg Leu Ala Trp Gly Pro Trp Ala Thr Cys Ala Arg Val Leu 130 135 140

Leu Phe Ser Tyr Asp Glu Leu Thr Arg Tyr Arg Val Cys Gly 145 150 155

(2) INFORMATION FOR SEQ ID NO: 42:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 423 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:42:

Val Pro Glu Gly Ala Trp Val Gly Gly Ala Cys Ala Arg Pro Arg Gly 1 5 10 15 Pro Arg Ala His Val Arg Leu Tyr Ala Val Cys Phe Val Cys Pro Gin

20 25 30

Gly Ile Arg Gly Gin Asp Phe Asn Leu Leu Phe Val Asp Glu Ala Asn 35 40 45 Phe Ile Arg Pro Asp Ala Val Gin Thr Ile Met Gly Phe Leu Asn Gin 50 55 60

Ala Asn Cys Lys Ile Ile Phe Val Ser Ser Thr Asn Thr Gly Lys Ala 65 70 75 80

Ser Thr Ser Phe Leu Tyr Asn Leu Arg Gly Ala Ala Asp Glu Leu Leu 85 90 95

Asn Val Val Thr Tyr Ile Cys Asp Asp His Met Pro Arg Val Val Thr

100 105 110

His Thr Asn Ala Thr Ala Cys Ser Cys Tyr Ile Leu Asn Lys Pro Val 115 120 125 Phe Ile Thr Met Asp Gly Ala Val Arg Arg Thr Ala Asp Leu Phe Leu 130 135 140

Pro Asp Ser Phe Met Gin Glu Ile Ile Gly Gly Gin Ala Arg Glu Thr 145 150 155 160

Gly Asp Asp Arg Pro Val Leu Thr Lys Ser Ala Gly Glu Arg Phe Leu 165 170 175

Leu Tyr Arg Pro Ser Thr Thr Thr Asn Ser Gly Leu Met Ala Pro Glu

180 185 190

Leu Tyr Val Tyr Val Asp Pro Ala Phe Thr Ala Asn Thr Arg Ala Ser 195 200 205 Gly Thr Gly Ile Ala Val Val Gly Arg Tyr Arg Asp Asp Phe Ile Ile 210 215 220

Phe Ala Leu Glu His Phe Phe Leu Arg Ala Leu Thr Gly Ser Ala Pro 225 230 235 240

Ala Asp Ile Ala Arg Cys Val Val His Ser Leu Ala Gin Val Leu Ala 245 250 255

Leu His Pro Gly Ala Phe Arg Ser Val Arg Val Ala Val Glu Gly Asn

260 265 270

Ser Ser Gin Asp Ser Ala Val Ala Ile Ala Thr His Val His Thr Glu 275 280 285 Met His Arg Ile Leu Ala Ser Ala Gly Ala Asn Gly Pro Gly Pro Glu 290 295 300

Leu Leu Phe Tyr His Cys Glu Pro Pro Gly Gly Ala Val Leu Tyr Pro 305 310 315 320

Phe Phe Leu Leu Asn Lys Gin Lys Thr Pro Ala Phe Glu Tyr Phe Ile 325 330 335

Lys Lys Phe Asn Ser Gly Gly Val Met Ala Ser Gin Glu Leu Val Ser

340 345 350

Val Thr Val Arg Leu Gin Thr Asp Pro Val Glu Tyr Leu Ser Glu Gin 355 360 365

Leu Asn Asn Leu Ile Glu Thr Val Ser Pro Asn Thr Asp Val Arg Met

370 375 - 380

Tyr Ser Gly Lys Arg Asn Gly Ala Ala Asp Asp Leu Met Val Ala Val 385 390 395 400

Ile Met Ala Ile Tyr Leu Ala Ala Pro Thr Gly Ile Pro Pro Ala Phe

405 410 415

Phe Pro Ile Thr Arg Thr Ser 420

(2) INFORMATION FOR SEQ ID NO: 43:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 355 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 43:

Val Leu Leu Ser Pro Ala Pro Pro Pro Leu Pro His Gly Arg Cys Pro

1 5 10 15

Pro Ser Leu Phe His His Arg Pro Gly Cys Val Ser Gly Pro Pro Ala 20 25 30

Pro Pro Arg Ser Gly Val Ser Arg Pro Gly Ala Met Ile Thr Asp Cys 35 40 45

Phe Glu Ala Asp Ile Ala Ile Pro Ser Gly Ile Ser Arg Pro Asp Ala 50 55 60

Ala Ala Leu Gin Arg Cys Glu Gly Arg Val Val Phe Leu Pro Thr Ile

65 70 75 80

Arg Arg Gin Leu Ala Asp Val Ala His Glu Ser Phe Val Ser Gly Gly

85 90 95

Val Ser Pro Asp Thr Leu Gly Leu Leu Leu Ala Tyr Arg Arg Arg Phe 100 105 110

Pro Ala Val Ile Thr Arg Val Leu Pro Thr Arg Ile Val Ala Cys Pro

115 120 125

Val Asp Leu Gly Leu Thr His Ala Gly Thr Val Asn Leu Arg Asn Thr 130 135 140

Ser Pro Val Asp Leu Cys Asn Gly Asp Pro Val Ser Leu Val Pro Pro

145 150 155 160

Val Phe Giu Gly Gin Ala Thr Asp Val Arg Leu Glu Ser Leu Asp Leu 165 170 175

Thr Leu Arg Phe Pro Val Pro Leu Pro Thr Pro Leu Ala Arg Glu Ile

180 _ 185 190

Val Ala Arg Leu Val Arg Ile Arg Asp Leu Asn Pro Asp Pro Arg Thr 195 200 205

Pro Gly Glu Leu Pro Asp Leu Asn Val Leu Tyr Tyr Asn Gly Ala Arg

210 215 220

Leu Ser Leu Val Ala Asp Val Gin Gin Leu Ala Ser Val Asn Thr Glu 225 230 235 240 Leu Arg Ser Leu Val Leu Asn Met Val Tyr Ser Ile Thr Glu Gly Thr

245 250 255

Thr Leu Ile Leu Thr Leu Ile Pro Arg Leu Leu Ala Leu Ser Ala Gin

260 265 270

Asp Gly Tyr Val Asn Ala Leu Leu Gin Met Gin Ser Val Thr Arg Glu 275 280 285

Ala Ala Gin Leu Ile His Pro Glu Ala Pro Met Leu Met Gin Asp Gly

290 295 300

Glu Arg Arg Leu Pro Leu Tyr Glu Ala Leu Val Ala Trp Leu Ala His 305 310 315 320 Ala Gly Gin Leu Gly Asp Ile Leu Ala Pro Ala Val Arg Val Cys Thr

325 330 335

Phe Asp Gly Ala Ala Val Val Gin Ser Gly Asp Met Ala Pro Val Ile

340 345 350

Arg Tyr Pro 355

(2) INFORMATION FOR SEQ ID NO: 44:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1382 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 44:

Val Trp Glu Gly Leu Gly Leu Pro Glu Leu Gly Leu Met Glu Pro Ala 1 5 10 15

Asn Pro Pro Arg Asn Pro Met Ala Ala Pro Ala Arg Asp Pro Pro Gly

20 25 30

Tyr Arg Tyr Ala Ala Ala Met Val Pro Thr Gly Ser Ile Leu Ser Thr 35 40 45

Ile Glu Val Ala Ser His Arg Arg Leu Phe Asp Phe Phe Ala Arg Val

50 55 _ 60

Arg Ser Asp Glu Asn Ser Leu Tyr Asp Val Glu Phe Asp Ala Leu Leu 65 70 75 80

Gly Ser Tyr Cys Asn Thr Leu Ser Leu Val Arg Phe Leu Glu Leu Gly

85 90 95

Leu Ser Val Ala Cys Val Cys Thr Lys Phe Pro Glu Leu Ala Tyr Met 100 105 110 Asn Glu Gly Arg Val Gin Phe Glu Val His Gin Pro Leu Ile Ala Arg 115 120 125

Asp Gly Pro His Pro Val Glu Gin Pro Val His Asn Tyr Met Thr Lys

130 135 140

Val Ile Asp Arg Arg Ala Leu Asn Ala Ala Phe Ser Leu Ala Thr Glu 145 150 155 160

Ala Ile Ala Leu Leu Thr Gly Glu Ala Leu Asp Gly Thr Gly Ile Ser

165 170 175

Leu His Arg Gin Leu Arg Ala Ile Gin Gin Leu Ala Arg Asn Val Gin 180 185 190 Ala Val Leu Gly Ala Phe Glu Arg Gly Thr Ala Asp Gin Met Leu His 195 200 205

Val Leu Leu Glu Lys Ala Pro Pro Leu Ala Leu Leu Leu Pro Met Gin

210 215 220

Arg Tyr Leu Asp Asn Gly Arg Leu Ala Thr Arg Val Ala Arg Ala Thr 225 230 235 240

Leu Val Ala Glu Leu Lys Arg Ser Phe Cys Asp Thr Ser Phe Phe Leu

245 250 255

Gly Lys Ala Gly His Arg Arg Glu Ala Ile Glu Ala Trp Leu Val Asp 260 265 270 Leu Thr Thr Ala Thr Gin Pro Ser Val Ala Val Pro Arg Leu Thr His 275 280 285

Ala Asp Thr Arg Gly Arg Pro Val Asp Gly Val Leu Val Thr Thr Ala

290 295 300

Ala Ile Lys Gin Arg Leu Leu Gin Ser Phe Leu Lys Val Glu Asp Thr 305 310 315 320

Glu Ala Asp Val Pro Val Thr Tyr Gly Glu Met Val Leu Asn Gly Ala

325 330 335

Asn Leu Val Thr Ala Leu Val Met Gly Lys Ala Val Arg Ser Leu Asp 340 345 350 Asp Val Gly Arg His Leu Leu Glu Met Gin Glu Glu Gin Leu Glu Ala 355 360 365

Asn Arg Glu Thr Leu Asp Glu Leu Glu Ser Ala Pro Gin Thr Thr Arg 370 375 380 Val Arg Ala Asp Leu Val Ala Ile Gly Asp Arg Leu Val Phe Leu Glu

385 390 395 400

Ala Leu Glu Lys Arg Ile Tyr Ala Ala Thr Asn Val Pro Tyr Pro Leu

405 410 415 Val Gly Ala Met Asp Leu Thr Phe Val Leu Pro Leu Gly Leu Phe Asn

420 425 430

Pro Ala Met Glu Arg Phe Ala Ala His Ala Gly Asp Leu Val Pro Ala

435 440 445

Pro Gly His Pro Glu Pro Arg Ala Phe Pro Pro Arg Gin Leu Phe Phe 450 455 460

Trp Gly Lys Asp His Gin Val Leu Arg Leu Ser Met Glu Asn Ala Val

465 470 475 480

Gly Thr Val Cys His Pro Ser Leu Met Asn Ile Asp Ala Ala Val Gly

485 490 495 Gly Val Asn His Asp Pro Val Glu Ala Ala Asn Pro Tyr Gly Ala Tyr

500 505 510

Val Ala Ala Pro Ala Gly Pro Gly Ala Asp Met Gin Gin Arg Phe Leu

515 520 525

Asn Ala Trp Arg Gin Arg Leu Ala His Gly Arg Val Arg Trp Val Ala 530 535 540

Glu Cys Gin Met Thr Ala Glu Gin Phe Met Gin Pro Asp Asn Ala Asn

545 550 555 560

Leu Ala Leu Glu Leu His Pro Ala Phe Asp Phe Phe Ala Gly Val Ala

565 570 575 Asp Val Glu Leu Pro Gly Gly Glu Val Pro Pro Ala Gly Pro Gly Ala

580 585 590

Ile Gin Ala Thr Trp Arg Val Val Asn Gly Asn Leu Pro Leu Ala Leu

595 600 605

Cys Pro Val Ala Phe Arg Asp Arg Leu Glu Leu Gly Val Gly Arg His 610 615 620

Ala Met Ala Pro Ala Thr Ile Ala Ala Val Arg Gly Ala Phe Glu Asp

625 630 635 640

Arg Ser Tyr Pro Ala Val Phe Tyr Leu Leu Gin Ala Ala Ile His Gly

645 650 655 Ser Glu His Val Phe Cys Ala Arg Leu Val Thr Gin Cys Ile Thr Ser

660 665 670

Tyr Trp Asn Asn Thr Arg Cys Ala Ala Phe Val Asn Asp Tyr Ser Leu

675 680 685

Val Ser Tyr Ile Val Thr Tyr Leu Gly Gly Asp Leu Pro Glu Glu Cys 690 695 700

Met Ala Val Tyr Arg Asp Leu Val Ala His Val Glu Ala Gin Leu Val 705 710 715 720

Asp Asp Phe Thr Leu Pro Gly Pro Glu Leu Gly Gly Gin Ala Gin Ala 725 730 735

Glu Leu Asn His Leu Met Arg Asp Pro Ala Leu Leu Pro Pro Leu Val

740 , 745 750

Trp Asp Cys Asp Gly Leu Met Arg His Ala Ala Leu Asp Arg His Arg 755 760 765

Asp Cys Arg Ile Asp Ala Gly Gly His Glu Pro Val Tyr Ala Ala Ala

770 775 780

Cys Asn Val Ala Thr Ala Asp Phe Asn Arg Asn Asp Gly Arg Leu Leu 785 790 795 800 His Asn Thr Gin Ala Arg Ala Ala Asp Ala Ala Asp Asp Arg Pro His

805 810 815

Arg Pro Ala Asp Trp Thr Val His His Lys Ile Tyr Tyr Tyr Val Leu

820 825 830

Val Pro Ala Phe Ser Arg Gly Arg Cys Cys Thr Ala Gly Val Arg Phe 835 840 845

Asp Arg Val Tyr Ala Thr Leu Gin Asn Met Val Val Pro Glu Ile Ala

850 855 860

Pro Gly Glu Glu Cys Pro Ser Asp Pro Val Thr Asp Pro Ala His Pro 865 870 875 880 Leu His Pro Ala Asn Leu Val Ala Asn Thr Val Asn Ala Met Phe His

885 890 895

Asn Gly Arg Val Val Val Asp Gly Pro Ala Met Leu Thr Leu Gin Val

900 905 910

Leu Ala His Asn Met Ala Glu Arg Thr Thr Ala Leu Leu Cys Ser Ala 915 920 925

Ala Pro Asp Ala Gly Ala Asn Thr Ala Ser Thr Ala Asn Met Arg Ile

930 935 940

Phe Asp Gly Ala Leu His Ala Gly Val Leu Leu Met Ala Pro Gin His 945 950 955 960 Leu Asp His Thr Ile Gin Asn Gly Glu Tyr Phe Tyr Val Leu Pro Val

965 970 975

His Ala Leu Phe Ala Gly Ala Asp His Val Ala Asn Ala Pro Asn Phe

980 985 990

Pro Pro Ala Leu Arg Asp Leu Ala Arg His Val Pro Leu Val Pro Pro 995 1000 1005

Ala Leu Gly Ala Asn Tyr Phe Ser Ser Ile Arg Gin Pro Val Val Gin

1010 1015 1020

His Ala Arg Glu Ser Ala Ala Gly Glu Asn Ala Leu Thr Tyr Ala Leu 1025 1030 1035 104 Met Ala Gly Tyr Phe Lys Met Ser Pro Val Tyr His Gin Leu Lys Thr

1045 1050 1055

Gly Leu His Pro Gly Phe Gly Phe Thr Val Val Arg Gin Asp Arg Phe 1060 1065 1070 Val Thr Glu Asn Val Leu Phe Ser Ala Ser Glu Ala Tyr Phe Leu Gly

1075 1080 1085

Gin Leu Gin Val Ala Arg His Glu Thr Gly Gly Gly Val Ser Phe Thr

1090 1095 1100 Leu Thr Gin Pro Arg Gly Asn Val Asp Leu Gly Val Gly Tyr Thr Ala

1105 1110 1115 112

Val Ala Ala Thr Ala Thr Val Arg Asn Pro Val Thr Asp Met Gly Asn

1125 1130 1135

Leu Pro Gin Asn Phe Tyr Leu Gly Arg Gly Ala Pro Pro Leu Leu Asn 1140 1145 1150

Asn Ala Ala Ala Val Tyr Leu Arg Asn Ala Val Val Ala Gly Asn Arg

1155 1160 1165

Leu Gly Pro Ala Gin Pro Leu Pro Val Phe Gly Cys Ala Gin Val Pro

1170 1175 1180 Arg Arg Ala Gly Met Asp His Gly Gin Asp Ala Val Cys Glu Phe Ile

1185 1190 1195 120

Ala Thr Pro Val Ala Thr Asp Ile Asn Tyr Phe Arg Arg Pro Cys Asn

1205 1210 1215

Pro Arg Gly Arg Ala Ala Gly Gly Val Tyr Ala Gly Asp Lys Glu Gly 1220 1225 1230

Asp Val Ile Ala Leu Met Tyr Asp His Gly Gin Ser Asp Pro Ala Arg

1235 1240 1245

Pro Phe Ala Ala Thr Ala Asn Pro Trp Ala Ser Gin Arg Phe Ser Tyr

1250 1255 1260 Gly Asp Leu Leu Tyr Asn Gly Ala Tyr His Leu Asn Gly Asp Val Leu

1265 1270 1275 128

Ser Pro Cys Phe Lys Phe Phe Thr Ala Ala Asp Ile Thr Ala Lys His

1285 1290 1295

Arg Cys Leu Glu Arg Leu Ile Val Glu Thr Gly Ser Ala Val Ser Thr 1300 1305 1310

Ala Thr Ala Ala Ser Asp Val Gin Phe Lys Arg Pro Pro Gly Cys Arg

1315 1320 1325

Glu Leu Val Glu Asp Pro Cys Gly Leu Phe Gin Glu Ala Tyr Pro Ile

1330 1335 1340 Thr Cys Ala Ser Asp Pro Ala Leu Leu Arg Ser Ala Arg Asp Gly Glu

1345 1350 1355 136

Ala His Ala Arg Glu Thr His Phe Thr Gin Tyr Leu Ile Tyr Asp Asp

1365 1370 1375

Leu Lys Gly Leu Ser Leu 1380

(2) INFORMATION FOR SEQ ID NO: 45: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 222 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 45:

Met Thr Met Arg Asp Asp Val Pro Leu Leu Asp Arg Glu Leu Val Tyr

1 5 10 15

Glu Ala Ala Cys Gly Gly Glu Asp Gly Glu Leu Pro Leu Asp Glu Gin 20 25 30 Phe Ser Leu Ser Ser Tyr Gly Thr Ser Asp Phe Phe Val Ser Ser Ala 35 40 45

Tyr Ser Arg Leu Pro Pro His Thr Gin Pro Val Phe Ser Lys Arg Val

50 55 60

Val Met Phe Ala Trp Ser Phe Leu Val Leu Lys Pro Leu Glu Leu Val 65 70 75 80

Ala Ala Gly Met Tyr Tyr Gly Trp Thr Gly Arg Ala Val Ala Pro Ala

85 90 95

Cys Ile Ile Ala Ala Val Leu Ala Tyr Tyr Val Thr Trp Leu Ala Arg 100 105 110 Ala Leu Leu Leu Tyr Val Asn Ile Lys Arg Asp Arg Leu Pro Leu Ser 115 120 125

Pro Pro Val Phe Trp Gly Leu Cys Val Ile Met Gly Gly Ala Ala Leu

130 135 140

Cys Ala Leu Val Ala Ala Ala His Glu Thr Phe Ser Pro Asp Gly Leu 145 150 155 160

Phe His Trp Ile Thr Ala Ser Gin Leu Leu Pro Arg Thr Asp Pro Leu

165 170 175

Arg Ala Arg Ser Leu Gly Ile Ala Cys Ala Ala Gly Ala Ala Met Trp 180 185 190 Val Ala Ala Ala Asp Cys Phe Ala Ala Phe Thr Asn Phe Phe Leu Ala 195 200 205

Arg Phe Trp Thr Arg Ala lie Leu Lys Ala Pro Val Ala Phe 210 215 220

(2) INFORMATION FOR SEQ ID NO: 46:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 627 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 46:

Val Gly Arg Gin Gly Glu Arg Trp Val Gly Gly Gly Asn Glu Lys Asn 1 5 10 15

Thr Gin Arg Ala Thr Ser Gly Met Arg Pro Glu Leu Ser Leu Lys Gly

20 25 30

Arg Pro Cys Val Thr Glu Ala Val Val Cys Pro Ser Thr Asp Ala Ala 35 40 45 Ile His Ser Gly Gly Ser Ser Ser Val Arg Pro Gin Pro Tyr Ala Arg 50 55 60

Ala Ala Arg Ala Arg Ala Thr His Gly Ser Arg Ser Arg His Arg Gin 65 70 75 80

Pro Leu Leu Pro Pro Pro Ser Ser His His Pro Thr Ile Pro Pro Pro 85 90 95

Pro Ser Pro Pro Arg Gly Ser Pro Ala Met Glu Leu Thr Tyr Ala Thr

100 105 110

Thr Leu His His Arg Asp Val Val Phe Tyr Val Thr Ala Asp Arg Asn 115 120 125 Arg Ala Tyr Phe Val Cys Gly Gly Ser Val Tyr Ser Val Gly Arg Pro 130 135 140

Arg Asp Ser Gin Pro Gly Glu Ile Ala Lys Phe Gly Leu Val Val Arg 145 150 155 160

Gly Thr Gly Pro Lys Asp Arg Met Val Ala Asn Tyr Val Arg Ser Glu 165 170 175

Leu Arg Gin Arg Gly Leu Arg Glu Val Arg Pro Val Gly Glu Asp Glu

180 185 190

Val Phe Leu Asp Ser Val Cys Leu Leu Asn Pro Asn Val Ser Ser Asp 195 200 205 Val Ile Asn Thr Asn Asp Val Glu Val Leu Asp Glu Cys Leu Ala Glu 210 215 220

Tyr Cys Thr Ser Leu Gin Thr Ser Pro Gly Val Leu Val Thr Gly Val 225 230 235 240

Arg Val Arg Ala Arg Asp Arg Val Ile Glu Leu Phe Glu His Pro Ala 245 250 255

Ile Val Asn Ile Ser Ser Arg Phe Ala Tyr Thr Pro Ser Pro Tyr Val

260 265 270

Phe Ala Gin Ala His Leu Pro Arg Leu Pro Ser Ser Leu Glu Pro Leu 275 280 285

Val Ser Gly Leu Phe Asp Gly Ile Pro Ala Pro Arg Gin Pro Leu Asp

290 295 300

Ala Arg Asp Arg Arg Thr Asp Val Val Ile Thr Gly Thr Arg Ala Pro 305 310 315 320

Arg Pro Met Ala Gly Thr Gly Ala Gly Gly Ala Gly Ala Lys Arg Ala

325 330 335

Thr Val Ser Glu Phe Val Gin Val Lys His Ile Asp Arg Val Val Ser 340 345 350 Pro Ser Val Ser Ser Ala Pro Pro Pro Ser Ala Pro Asp Ala Ser Leu 355 360 365

Pro Pro Pro Gly Leu Gin Glu Ala Ala Pro Pro Gly Pro Pro Leu Arg

370 375 380

Glu Leu Trp Trp Val Phe Tyr Ala Gly Asp Arg Ala Leu Glu Glu Pro 385 390 395 400

His Ala Glu Ser Gly Leu Thr Arg Glu Glu Val Arg Ala Val His Gly

405 410 415

Phe Arg Glu Gin Ala Trp Lys Leu Phe Gly Ser Val Gly Ala Pro Arg 420 425 430 Ala Phe Leu Gly Ala Ala Leu Ser Pro Thr Gin Lys Leu Ala Val Tyr 435 440 445

Tyr Tyr Leu Ile His Arg Glu Arg Arg Met Ser Pro Phe Pro Ala Leu

450 455 460

Val Arg Leu Val Gly Arg Tyr Ile Gin Arg His Gly Val Pro Ala Pro 465 470 475 480

Asp Glu Pro Thr Leu Ala Asp Ala Met Asn Gly Leu Phe Arg Asp Ala

485 490 495

Ala Gly Thr Val Ala Glu Gin Leu Leu Met Phe Asp Leu Leu Pro Pro 500 505 510 Lys Asp Val Pro Val Gly Ser Asp Ala Arg Ala Asp Ser Ala Ala Leu 515 520 525

Leu Arg Phe Val Asp Ser Gin Arg Leu Thr Pro Gly Gly Ser Val Ser

530 535 540

Pro Glu His Val Met Tyr Leu Gly Ala Phe Leu Gly Val Leu Tyr Ala 545 550 555 560

Gly His Gly Arg Leu Ala Ala Ala Thr His Thr Ala Arg Leu Thr Gly

565 570 575

Val Thr Ser Leu Val Leu Thr Val Gly Asp Val Asp Arg Met Ser Ala 580 585 590 Phe Asp Arg Gly Pro Ala Gly Ala Ala Gly Arg Thr Arg Thr Ala Gly 595 600 605

Tyr Leu Asp Ala Leu Leu Thr Val Cys Leu Ala Arg Ala Gin His Gly 610 615 620 Gin Ser Val 625

(2) INFORMATION FOR SEQ ID NO: 47:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 592 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 47:

Val Tyr Leu Ser Pro Ser Ala Leu Lys Trp Pro Val Gly Val Trp Thr

1 5 10 15

Thr Gly Gly Leu Ala Phe Gly Cys Asp Ala Ala Leu Val Arg Ala Arg 20 25 30 Tyr Gly Lys Gly Phe Met Gly Val Val Ile Ser Met Arg Asp Ser Pro 35 40 45

Pro Ala Glu lie Ile Val Val Pro Ala Asp Lys Thr Leu Ala Arg Val

50 55 60

Gly Asn Pro Thr Asp Glu Asn Ala Pro Ala Val Leu Pro Gly Pro Pro 65 70 75 80

Ala Gly Pro Arg Tyr Arg Val Phe Val Leu Gly Ala Pro Thr Pro Ala

85 90 95

Asp Asn Gly Ser Ala Leu Asp Ala Leu Arg Arg Val Ala Gly Tyr Pro 100 105 110 Glu Glu Ser Thr Asn Tyr Ala Gin Tyr Met Ser Arg Ala Tyr Ala Glu 115 120 125

Phe Leu Gly Glu Asp Pro Gly Ser Gly Thr Asp Ala Arg Pro Ser Leu

130 135 140

Phe Trp Arg Leu Ala Gly Leu Leu Ala Ser Ser Gly Phe Ala Phe Val 145 150 155 160

Asn Ala Ala His Ala His Asp Ala Ile Arg Leu Ser Asp Leu Leu Gly

165 170 175

Phe Leu Ala His Ser Arg Val Leu Ala Gly Leu Ala Arg Ala Ala Gly 180 185 190 Cys Ala Ala Asp Ser Val Phe Leu Asn Val Ser Val Leu Asp Pro Ala 195 200 205

Ala Arg Leu Arg Leu Glu Ala Arg Leu Gly His Leu Val Ala Ala Ile 210 215 220 Arg Glu Gin Ser Leu Ala Ala His Ala Leu Gly Tyr Gin Leu Ala Phe

225 230 235 240

Val Leu Asp Ser Pro Ala Ala Tyr Gly Ala Val Ala Pro Ser Ala Ala

245 250 255 Arg Leu Ile Asp Ala Leu Tyr Ala Glu Phe Leu Gly Gly Arg Ala Leu

260 265 270

Thr Ala Pro Met Val Arg Arg Ala Leu Phe Tyr Ala Thr Ala Val Leu

275 280 285

Arg Ala Pro Phe Leu Ala Gly Ala Pro Ser Ala Glu Gin Arg Glu Arg 290 295 300

Ala Arg Arg Gly Leu Leu Ile Thr Thr Ala Leu Cys Thr Ser Asp Val

305 310 315 320

Ala Ala Ala Thr His Ala Asp Leu Arg Ala Ala Arg Thr Asp His Gin

325 330 335 Lys Asn Leu Phe Trp Leu Pro Asp His Phe Ser Pro Cys Ala Ala Ser

340 345 350

Leu Arg Phe Asp Leu Ala Glu Gly Gly Phe Ile Leu Asp Ala Met Ala

355 360 365

Thr Arg Ser Asp Ile Pro Ala Asp Val Met Ala Gin Gin Thr Arg Gly 370 375 380

Val Ala Ser Val Leu Thr Arg Trp Ala His Tyr Asn Ala Leu Ile Arg

385 390 395 400

Ala Phe Val Pro Glu Ala Thr His Gin Cys Ser Gly Pro Ser His Asn

405 410 415 Ala Glu Pro Arg lie Leu Val Pro Ile Thr His Asn Ala Ser Tyr Val

420 425 430

Val Thr His Thr Pro Leu Pro Arg Gly Ile Gly Tyr Lys Leu Thr Gly

435 440 445

Val Asp Val Arg Arg Pro Leu Phe Ile Thr Tyr Leu Thr Ala Thr Cys 450 455 460

Glu Gly His Ala Arg Glu Ile Glu Pro Lys Arg Leu Val Arg Thr Glu

465 470 475 480

Asn Arg Arg Asp Leu Gly Leu Val Gly Ala Val Phe Leu Arg Tyr Thr

485 490 495 Pro Ala Gly Glu Val Met Ser Val Leu Leu Val Asp Thr Asp Ala Thr

500 505 510

Gin Gin Gin Leu Ala Gin Gly Pro Val Ala Gly Thr Pro Asn Val Phe

515 520 525

Ser Ser Asp Val Pro Ser Val Leu Leu Phe Pro Asn Gly Thr Val Ile 530 535 540

His Leu Leu Ala Phe Asp Thr Leu Pro Ile Ala Thr Ile Ala Pro Gly 545 550 555 560

Phe Leu Ala Ala Ser Ala Leu Gly Val Val Met Ile Thr Ala Ala Gly 565 570 575

Ile Leu Arg Val Val Arg Thr Cys Val Pro Phe Leu Trp Arg Arg Glu 580 585 590

(2) INFORMATION FOR SEQ ID NO: 48:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 315 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 48:

Val Ser Ile Ser Ala Gly Val Arg Gly Gin Gly Trp His Arg Ile Ser

1 5 10 15

Thr Pro Pro Lys Asn Gly Ala Gly Arg Ser Val Leu Val Phe Gly Leu 20 25 30

Val Leu Pro Leu Cys Phe Tyr Pro His Pro Thr Pro Ser Phe Gly Pro

35 40 45

Arg Leu Arg Gin Gin Arg Ala Ser Asp Ser Leu Arg Gly Ala Glu Pro 50 55 60 Leu Trp Ala Val Gly Thr Asp Thr Pro Pro Ser Ala Asp Trp Gin Pro 65 70 75 80

Gly Arg Thr Thr Met Gly Pro Gly Leu Trp Val Val Met Gly Val Leu

85 90 95

Val Gly Val Ala Gly Gly His Asp Thr Tyr Trp Thr Glu Gin Ile Asp 100 105 110

Pro Trp Phe Leu His Gly Leu Gly Leu Ala Arg Thr Tyr Trp Arg Asp

115 120 125

Thr Asn Thr Gly Arg Leu Trp Leu Pro Asn Thr Pro Asp Ala Ser Asp

130 135 140 Pro Gin Arg Gly Arg Leu Ala Pro Pro Gly Glu Leu Asn Leu Thr Thr

145 150' 155 160

Ala Ser Val Pro Met Leu Arg Trp Tyr Ala Glu Arg Phe Cys Phe Val

165 170 175

Leu Val Thr Thr Ala Glu Phe Pro Arg Asp Pro Gly Gin Leu Leu Tyr 180 185 190

Ile Pro Lys Thr Tyr Leu Leu Gly Arg Pro Arg Asn Ala Ser Leu Pro

195 200 205

Glu Leu Pro Glu Ala Gly Pro Thr Ser Arg Pro Pro Ala Glu Val Thr 210 215 220

Gin Leu Lys Gly Leu Ser His Asn Pro Gly Ala Ser Ala Leu Leu Arg 225 230 235 240

Ser Arg Ala Trp Val Thr Phe Ala Ala Ala Pro Asp Arg Glu Gly Leu 245 250 255

Thr Phe Pro Arg Gly Asp Asp Gly Ala Thr Glu Arg His Pro Asp Gly

260 265 270

Arg Arg Asn Ala Pro Pro Pro Gly Pro Pro Ala Gly Thr Pro Arg His 275 280 285 Pro Thr Thr Asn Leu Ser Ile Ala His Leu His Asn Ala Ser Val Thr 290 295 300

Trp Leu Ala Arg Leu Leu Arg Thr Pro Gly Arg 305 310 315

(2) INFORMATION FOR SEQ ID NO: 49:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 370 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 49:

Met Ala Ser His Ala Gly Gin Gin His Ala Pro Ala Phe Gly Gin Ala

1 5 10 15

Ala Arg Ala Ser Gly Pro Thr Asp Gly Arg Ala Ala Ser Arg Pro Ser 20 25 30

His Arg Gin Gly Ala Ser Asp Pro Glu Leu Pro Thr Leu Leu Arg Val

35 40 45

Tyr Ile Asp Gly Pro His Gly Val Gly Lys Thr Thr Thr Ser Ala Gin 50 55 60 Leu Met Glu Ala Leu Gly Pro Arg Asp Asn Ile Val Tyr Val Pro Glu 65 70 75 80

Pro Met Thr Tyr Trp Gin Val Leu Gly Ala Ser Glu Thr Leu Thr Asn

85 90 95

Ile Tyr Asn Thr Gin His Arg Leu Asp Arg Gly Glu Ile Ser Ala Gly 100 105 110

Glu Ala Ala Val Val Met Thr Ser Ala Gin Ile Thr Met Ser Thr Pro

115 120 125

Tyr Ala Ala Thr Asp Ala Val Leu Ala Pro His Ile Gly Gly Glu Ala 130 135 140

Val Gly Pro Gin Ala Pro Pro Pro Ala Leu Thr Leu Val Phe Asp Arg 145 150 155 160

His Pro Ile Ala Ser Leu Leu Cys Tyr Pro Ala Ala Arg Tyr Leu Met 165 170 175

Gly Ser Met Thr Pro Gin Ala Val Leu Ala Phe Val Met Pro Pro Thr

180 185 190

Ala Pro Gly Thr Asn Leu Val Leu Gly Val Leu Pro Glu Ala Glu His 195 200 205 Ala Asp Arg Leu Ala Arg Arg Gin Arg Pro Gly Glu Arg Leu Asp Leu 210 215 220

Ala Met Leu Ser Ala Ile Arg Arg Val Tyr Asp Leu Leu Ala Asn Thr 225 230 235 240

Val Arg Tyr Leu Gin Arg Gly Gly Arg Trp Arg Glu Asp Trp Gly Arg 245 250 255

Leu Thr Gly Val Ala Ala Ala Thr Pro Arg Pro Asp Pro Glu Asp Gly

260 265 270

Ala Gly Ser Leu Pro Arg Ile Glu Asp Thr Leu Phe Ala Leu Phe Arg 275 280 285 Val Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu Tyr His Ile Phe Ala 290 295 300

Trp Val Leu Asp Val Leu Ala Asp Arg Leu Leu Pro Met His Leu Phe 305 310 315 320

Val Leu Asp Tyr Asp Gin Ser Pro Val Gly Cys Arg Asp Ala Leu Leu 325 330 335

Arg Leu Thr Ala Gly Met Ile Pro Thr Arg Val Thr Thr Ala Gly Ser

340 345 350

Ile Ala Glu Ile Arg Asp Leu Ala Arg Thr Phe Ala Arg Glu Val Gly 355 360 365 Gly Val 370

(2) INFORMATION FOR SEQ ID NO: 50:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 352 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 50: Val Leu Arg Val Val Asp Val Arg Gin Gly Leu Gly Gly Pro Gin His

1 5 _, 10 15

Leu Pro Val Ser His Arg Leu Gly Asp Val Asp Asp Ile Val Ala Arg 20 25 30

Pro Gin Gly Leu His Gin Leu Arg Gly Gly Gly Gly Leu Pro His Pro

35 40 45

Val Gly Ser Val Tyr Ile Asn Pro Gin Gin Arg Gly Gin Leu Arg Ile 50 55 60 Pro Ala Gly Phe Gly Gly Pro Leu Ala Met Ala Arg Thr Gly Arg Arg 65 70 75 80

Ala Ala Val Gly Arg Pro Ala Arg Thr Ser Ser Leu Thr Glu Arg Arg

85 90 95

Arg Val Leu Leu Ala Gly Val Arg Ser His Thr Arg Phe Tyr Lys Ala 100 105 110

Phe Ala Arg Glu Val Arg Glu Phe Asn Ala Thr Arg Ile Cys Gly Thr

115 120 125

Leu Leu Thr Leu Met Ser Gly Ser Leu Gin Gly Arg Ser Leu Phe Glu

130 135 140 Ala Thr Arg Val Thr Leu Ile Cys Glu Val Asp Leu Gly Pro Arg Arg

145 150 155 160

Pro Asp Cys Ile Cys Val Phe Glu Phe Ala Asn Asp Lys Thr Leu Gly

165 170 175

Gly Val Cys Val Ile Leu Lys Thr Cys Lys Ser Ile Ser Ser Gly Asp 180 185 190

Thr Ala Ser Lys Arg Glu Gin Arg Thr Thr Gly Met Lys Gin Leu Arg

195 200 205

His Ser Leu Lys Leu Leu Gin Ser Leu Ala Pro Pro Gly Asp Lys Val

210 215 220 Val Tyr Leu Cys Pro Ile Leu Val Phe Val Ala Gin Arg Thr Leu Arg

225 230 235 240

Val Ser Arg Val Thr Arg Leu Val Pro Gin Lys Ile Ser Gly Asn Ile

245 250 255

Thr Ala Ala Val Arg Met Leu Gin Ser Leu Ser Thr Tyr Ala Val Pro 260 265 270

Pro Glu Pro Gin Thr Arg Arg Ser Arg Arg Arg Val Ala Ala Thr Ala

275 280 285

Arg Pro Gin Arg Pro Pro Ser Pro Thr Arg Asp Pro Glu Gly Thr Ala 290 295 300 Gly His Pro Ala Pro Pro Glu Ser Asp Pro Pro Ser Pro Gly Val Val 305 310 315 320

Gly Val Ala Ala Glu Gly Gly Gly Val Leu Gin Lys Ile Ala Ala Leu 325 330 335 Phe Cys Val Pro Val Ala Ala Lys Ser Arg Pro Arg Thr Lys Thr Glu 340 345 350

(2) INFORMATION FOR SEQ ID NO: 51:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 514 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 51:

Met Asp Pro Tyr Tyr Pro Phe Asp Ala Leu Asp Val Trp Glu His Arg

1 5 10 15

Arg Phe Ile Val Ala Asp Ser Arg Ser Phe Ile Thr Pro Glu Phe Pro 20 25 30 Arg Asp Phe Trp Met Leu Pro Val Phe Asn Ile Pro Arg Glu Thr Ala 35 40 45

Ala Glu Arg Ala Ala Val Met Gin Ala Gin Arg Thr Ala Ala Ala Ala

50 55 60

Ala Leu Glu Asn Ala Ala Leu Gin Ala Ala Glu Leu Pro Val Asp Ile 65 70 75 80

Glu Arg Arg Ile Arg Pro Ile Glu Gin Gin Val His His Ile Ala Asp

85 90 95

Ala Leu Glu Ala Leu Glu Thr Ala Ala Ala Ala Ala Glu Glu Ala Asp 100 105 110 Ala Ala Arg Asp Ala Glu Arg Glu Gly Ala Ala Asp Gly Ala Ala Pro 115 120 125

Ser Pro Thr Ala Gly Pro Ala Ala Ala Glu Met Glu Val Gin Ile Val

130 135 140

Arg Asn Asp Pro Pro Leu Arg Tyr Asp Thr Asn Leu Pro Val Asp Leu 145 150 155 160

Leu His Met Val Tyr Ala Gly Arg Gly Ala Ala Gly Ser Ser Gly Val

165 170 175

Val Phe Gly Thr Trp Tyr Arg Thr Ile Gin Glu Arg Thr Ile Ala Asp 180 185 190 Phe Pro Leu Thr Thr Arg Ser Ala Asp Phe Arg Asp Gly Arg Met Ser 195 200 205

Lys Thr Phe Met Thr Ala Leu Val Leu Ser Leu Gin Ser Cys Gly Arg 210 215 220 Leu Tyr Val Gly Gin Arg His Tyr Ser Ala Phe Glu Cys Ala Val Leu

225 230 235 240

Cys Leu Tyr Leu Leu Tyr Arg Thr Thr His Glu Ser Ser Pro Asp Arg 245 250 255

Asp Arg Ala Pro Val Ala Phe Gly Asp Leu Leu Ala Arg Leu Pro Arg

260 265 270

Tyr Leu Ala Arg Leu Ala Ala Val Ile Gly Asp Glu Ser Gly Arg Pro

275 280 285

Gin Tyr Arg Tyr Arg Asp Asp Lys Leu Pro Lys Ala Gin Phe Ala Ala 290 295 300

Ala Gly Gly Arg Tyr Glu His Gly Ala Thr His Val Val Ile Ala Thr

305 310 315 320

Leu Val Arg His Gly Val Leu Pro Ala Ala Pro Gly Asp Val Pro Arg 325 330 335

Asp Thr Ser Thr Arg Val Asn Pro Asp Asp Val Ala His Arg Asp Asp 340 345 350

Val Asn Arg Ala Ala Ala Ala Phe Leu Arg His Asn Leu Phe Leu Trp 355 360 365

Glu Asp Gin Thr Leu Leu Arg Ala Thr Ala Asn Thr Ile Thr Ala Val 370 375 380

Leu Arg Arg Leu Leu Ala Asn Gly Asn Val Tyr Ala Asp Arg Leu Asp

385 390 395 400

Asn Arg Leu Gin Leu Gly Met Leu Ile Pro Gly Ala Val Pro Ala Glu 405 410 415

Ala Ile Arg Ala Ser Gly Leu Asp Ser Gly Ala Ile Lys Ser Gly Asp 420 425 430

Asn Asn Leu Glu Ala Leu Cys Val Asn Tyr Val Leu Pro Leu Tyr Gin 435 440 445

Ala Asp Pro Thr Val Glu Leu Thr Gin Leu Phe Pro Gly Ala Gly Arg 450 455 460

Pro Val Pro Gly Arg Pro Gly Gly Ala Ala Thr Gly Val Asp Glu Arg

465 470 475 480

Gly Tyr Val Val Gly Arg Pro Pro Gly Gly Ala Arg Ala Pro His Arg

485 490 495

Ala Gly Ala His Gin Pro His Pro His Lys His His Pro Cys Gly Gly 500 505 510

Asp Tyr

(2) INFORMATION FOR SEQ ID NO: 52:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 91 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 52:

Val Val Asp Met Leu Ser Gly Ala Arg Gin Ala Ala Leu Val Arg Leu 1 5 10 15

Thr Ala Leu Glu Leu Ile Asn Arg Thr Arg Thr Asn Thr Thr Pro Val

20 25 30

Gly Glu Ile Ile Asn Ala His Asp Ala Leu Gly Ile Gin Tyr Glu Gin 35 40 45 Gly Leu Gly Leu Leu Ala Gin Gin Ala Arg Ile Gin Ala Lys Arg Phe 50 55 60

Ala Thr Phe Asn Val Gly Ser Asp Tyr Asp Leu Leu Tyr Phe Leu Cys 65 70 75 80

Leu Gly Phe Ile Pro Gin Tyr Leu Ser Val Ala 85 90

(2) INFORMATION FOR SEQ ID NO: 53:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 444 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 53:

Val Arg Val Pro Met Ala Ser Ala Glu Met Arg Glu Arg Leu Glu Ala 1 5 10 15

Pro Leu Pro Asp Arg Ala Val Pro Ile Tyr Val Ala Gly Phe Leu Ala

20 25 30

Leu Tyr Asp Ser Gly Asp Pro Gly Glu Leu Ala Leu Asp Pro Asp Thr 35 40 45 Val Arg Ala Ala Leu Pro Pro Glu Asn Pro Leu Pro Ile Asn Val Asp 50 55 60

His Arg Ala Arg Cys Glu Val Gly Arg Val Leu Ala Val Val Asn Asp 65 70 75 80 Pro Arg Gly Pro Phe Phe Val Gly Leu Ile Ala Cys Val Gin Leu Glu

85 90 95

Arg Val Leu Glu Thr Ala Ala Ser Ala Ala Ile Phe Glu Arg Arg Gly 100 105 110 Pro Ala Leu Ser Arg Glu Glu Arg Leu Leu Tyr Leu Ile Thr Asn Tyr 115 120 125

Leu Pro Ser Val Ser Leu Ser Thr Lys Arg Arg Gly Asp Glu Val Pro

130 135 140

Pro Asp Arg Thr Leu Phe Ala His Val Cys Ala Ile Gly Arg Arg Leu 145 150 155 160

Gly Thr Ile Val Thr Tyr Asp Thr Ser Leu Asp Ala Ala Ile Ala Pro

165 170 175

Phe Arg His Leu Asp Pro Ala Thr Arg Glu Gly Val Arg Arg Glu Ala 180 185 190 Ala Glu Ala Glu Leu Ala Gly Arg Thr Trp Ala Pro Gly Val Glu Ala 195 200 205

Leu Thr His Thr Leu Leu Ser Thr Ala Val Asn Asn Met Met Leu Arg

210 215 220

Asp Arg Trp Ser Leu Val Ala Glu Arg Arg Arg Gin Ala Gly Ile Ala 225 230 235 240

Gly His Thr Tyr Leu Gin Ala Ser Glu Lys Phe Lys Ile Trp Gly Ala

245 250 255

Glu Ser Ala Pro Ala Pro Glu Arg Gly Tyr Lys Thr Gly Ala Pro Gly 260 265 270 Ala Met Asp Thr Ser Pro Ala Ala Ser Val Pro Ala Pro Gin Val Ala 275 280 285

Val Arg Ala Arg Gin Val Ala Ser Ser Ser Ser Ser Ser Ser Ser Phe

290 295 300

Pro Ala Pro Ala Asp Met Asn Pro Val Ser Ala Ser Gly Ala Pro Ala 305 310 315 320

Pro Pro Pro Pro Gly Asp Gly Ser Tyr Leu Trp Ile Pro Ala Phe His

325 330 335

Tyr Asn Gin Leu Val Thr Gly Gin Ser Ala Pro His His Pro Pro Leu 340 345 350 Thr Ala Cys Gly Leu Pro Ala Ala Gly Thr Val Ala Tyr Gly His Pro 355 360 365

Gly Ala Gly Pro Ser Pro His Tyr Pro Pro Pro Pro Ala His Pro Tyr

370 375 380

Pro Gly Tyr Ala Val Arg Gly Pro Gin Ser Pro Gly Gly Pro Asp Arg 385 390 395 400

Arg Ala Gly Gly Gly His Arg Arg Arg Pro Pro Gly Gly Trp Ala Ser

405 410 415

Gly Gly Arg Arg Arg Pro Arg Asp Pro Gly Val Gly Glu Pro Pro Pro 420 425 430

Thr Arg Gly Gly Ala Ala Gly Val Arg Leu Arg Pro 435 440

(2) INFORMATION FOR SEQ ID NO: 54:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 250 amino acids

(B) TYPE: amino acid (C)^' STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 54:

Met Leu Phe Ala Gly Pro Ser Pro Leu Glu Ala Gin Ile Ala Ala Leu

1 5 10 15

Val Gly Ala Ile Ala Ala Asp Arg Gin Ala Gly Gly Leu Pro Ala Ala 20 25 30

Ala Gly Asp His Gly Ile Arg Gly Ser Ala Asn Arg Arg Arg His Glu

35 40 45

Val Glu Gin Pro Glu Tyr Asp Cys Gly Arg Asp Glu Pro Asp Arg Asp 50 55 60 Phe Pro Tyr Tyr Pro Gly Glu Ala Arg Pro Glu Pro Arg Pro Val Asp 65 70 75 80

Ser Arg Arg Ala Ala Arg Gin Ala Ser Gly Phe Thr Ile Thr Ala Leu

85 90 95

Val Gly Ala Val Thr Ser Leu Gin Gin Glu Leu Ala His Met Arg Ala 100 105 110

Arg Thr His Ala Pro Tyr Gly Pro Tyr Pro Pro Val Gly Pro Tyr His

115 120 125

His Pro His Ala Asp Thr Glu Thr Pro Ala Gin Pro Pro Arg Tyr Pro

130 135 140 Ala Glu Ala Val Tyr Leu Pro Pro Pro His Ile Ala Pro Pro Gly Pro

145 150 155 160

Pro Leu Ser Gly Ala Val Pro Pro Pro Ser Tyr Pro Pro Val Ala Val

165 170 175

Thr Pro Gly Pro Ala Pro Pro Leu His Gin Pro Ser Pro Ala His Ala 180 185 190

His Pro Pro Pro Pro Pro Pro Gly Pro Thr Pro Pro Pro Ala Ala Ser

195 200 205

Leu Pro Gin Pro Glu Ala Pro Gly Ala Glu Ala Gly Ala Leu Val Asn 210 215 220

Ala Ser Ser Ala Ala His Val Asn Val Asp Thr Ala Arg Ala Ala Asp 225 230 235 240

Leu Phe Val Ser Gin Met Met Gly Ser Arg 245 250

(2) INFORMATION FOR SEQ ID NO: 55:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1161 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 55:

CCTGGCACCT TGTAGCAGTC CACCTATAGG ATACCCCAGC ACTTTGGGAG GCCGAGGCAG 60

ACGGATCACA AGTTCAGGAG ATCGAAACCA TCCTGGCCAA CATGGTAAAA CCCCGTCTCT 120 ACTAAAAACG TAAAAATTAN CTGAGTGTGG TGGTGTGTGC CTGTACTCCC AGCTACTTGG 180

GAGGCTGAGG CAAAAAATTC ACTTGAACCT GGGAGGTGGA GGTTGCACTG AGCTGAGGTC 240

ATGCCACTGC ACTCCAGCCT AGCAACAGAG TGAGACTCCA TCTCAAAAAA ATAAATAAAT 300

AAATAAATAA ATAAATAAAG ACATATGGAG GCCTTACTCT GTGCCAAGCA CTATGATGGG 360

CACAGGGAAC AAACACACGG GCTCCCTGAG CACCAGCGGT GAGCCAGGCA CCGTGCCTGG 420 AGACCAACGT CTGGCGTTTT GTATGCGGAC ATGATACCCG GCACTCTCCC CTATGGCTAA 480 TGAATCATCG AGCTTCACCA GAGAAACGCG AACAGACCCC CTTGTCCATG AATTTGCTAA 540 TTGACCTCCC CCAACTCAGA CATCAACCCT GCATTACCAT AAATTACTGG CTAAGAAACA 600 CCCGTTCTCA ACCTGCTGGC CTCAATGGGT TACACGTCCC ACAAACCCCT TTCCCAAGGT 660 GAAATACCAA CCTCGAAAAC TCGGAAAATT CAAGTTCAAC AACCTCCGGG ATTGCGGGCT 720 TTACCAGCGA AGCCCTCTCC AAAAATTTGC TCGCTTAGAC ATCCAACCGC TTCTCCACTA 780 AAGACCCCGG CTTCTTCTCA CCTCGGCGTT CTCTTGCAAA AAATACGCGT CTGTTAATCC 840 GCGCCCCTCT TCCTCACACA CTTCTCCCCT GCCTACTCAT ACCTCATCTC TCCTATAACC 900 CTCTCGCGAA AGAGCCCCTG TCTCTCACCT GTTTAATACC ACCCATGCGG GCGGGTTGTC 960

CCTTAAATGG ATATTCTGAA CCTCAACCCT CCCCCCATTC TAATTTGGCG TGTTGGCCCC 1020 CTCACCTGCC CCCTCCTCTC CCAAAGTCCG GGAATATCCG TTCCCTGGCC ACCCTCCTTC 1080

TTTATGAAAC CCGGCTTACC CCCCCGGGGA AATAGGCCGT TTGGCTTTTG TGGCGCGCCC 1140

TTCCACCTTC CCCTCTACAA 1161

(2) INFORMATION FOR SEQ ID NO: 56:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 56:

Val Lys Tyr Gin Pro Arg Lys Leu Gly Lys Phe Lys Phe Asn Asn Leu 1 5 10 15 Arg Asp Cys Gly Gin Arg Ser Pro Leu Gin Lys Phe Ala Arg Leu Asp 20 25 30

Ile Gin Pro Leu Leu His 35

(2) INFORMATION FOR SEQ ID NO: 57:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 524 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 57:

GCAGGTCGAT CTAGAAGTCC CCAGGGGTCA GGGGTCTCAC TTGAGAAGGT AGTCTGTCCG 60

TTCTCCAATC TCAACCTCCG TGTTGGGAGA TCCACTGCTC ACTTCAAAGC TGTGAGACAG 120

AGTTGTTTGC GTCTGCAGAG GTTTCAGCTG CTTTTTGTTG TTGTAGTCGT CGTCGTTGTT 180

GTTGTTGTTG TTGTTTAGCT GTGCCCTGTC CCCAGAGGTG GAGTCTACAG AGACAGGCAG 240 GACTCCTTGA GCTGCTGTGA GCTCCACCCA GTTGGAGCTT CCCAGCTGCT TTGTTTATCT 300

ACTTAAGCCT CAGTAATGGC GGGCGCCCCT CCCCCAACCT CGCTGCTGCC TTGCCCCCAG 360

ATCGCAGACT GCTGTGCTAA CAACGAGGGA GGCCCTGTGG GCATGGGACC CTCCTGGCCA 420

NGTGTGGGAT ATANTCTCCT GGTTGTGCCC GTTGGTAAAA TTTCTGGGTA AACCCCATAT 480

TGGGGGTTTG AATTCCCCAA ATTTCCCAGT TTGTTTTGTG TCT 524

(2) INFORMATION FOR SEQ ID NO: 58:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 76 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 58:

Val Glu Leu Thr Ala Ala Gin Gly Val Leu Pro Val Ser Val Asp Ser 1 5 10 15

Thr Ser Gly Asp Arg Ala Gin Leu Asn Asn Asn Asn Asn Asn Asn Asp

20 25 30

Asp Asp Tyr Asn Asn Lys Lys Gin Leu Lys Pro Leu Gin Thr Gin Thr 35 40 45

Thr Leu Ser His Ser Phe Glu Val Ser Ser Gly Ser Pro Asn Thr Glu

50 55 60

Val Glu Ile Gly Glu Arg Thr Asp Tyr Leu Leu Lys 65 70 75

(2) INFORMATION FOR SEQ ID NO: 59:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 773 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 59:

GGAAGAGGGC GCTGTTGCCC GCGCTCCTTG CGCGGTGGCG GCGGGGGGCA GGCGGAGGCA 60

GGCGCGGCGT GCGGGGCCTC CGGCGCCTTC CCCCCGCCCT CGCTCGGGGG GCTGTTCGCC 120

CACTCTGCGT CGTCGTTGCC GGCGTAATCC GCGTCGTCGC TGTCGTCCGC CTGGGGCACC 180 AGCAGCCAGC GCCGCAGGAG CGATGACGCG GCCGGCGCGC TCTCGACCGC GGTTCCCGAG 240

TCGTACGCAG GGACCATTTG GGAGTCTGCG GTTGGGAACG CGCCGGGGCG CGGCACGGTT 300

GGACCGCCGG GGCGCGGCCG GCGCCGGGGA CCCCGGCGGC GGGGACTCCG GCGGGACATG 360

GAGGGCGGCT GGGCTCGGCC TATGCCCGGA TCCGGATCGC GTCTGGGCGG GAGATTTCAC 420

TCGGCACGCA TGCACGTCTC CCCCCCCCCC CGTGGTTGCC TATGAAACTA CCCCGTCCCG 480 CTGGTGTGCG CATTTCTGTC CGCGTTGCCG GCCTTCTTTG CGGCGCGTGG CTTGACTGGG 540

ATCCCCTCCC CTCTCCCTTC CCCTCCGGGA TTCACCCCCG GGGGGGGTTT TTCTGGGGGG 600

GGGGTTAATA GCTGTCTGTC CCCTCCCCAC CGTTTCCTCC CTGGACTCCA CGGCGCTCCA 660

TAACTCTCTC CTGGTCCACC CCCCATTCCC CACATGGCCT TTGCTTTTCA ACCCCCCCCT 720

CCGGTTGGGC TGCATATCAA TTTCCTTCTC CCCCGGGGGA TCCCCTATTA CG 773

(2) INFORMATION FOR SEQ ID NO: 60:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 121 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 60:

Met Ser Arg Arg Ser Pro Arg Arg Arg Gly Pro Arg Arg Arg Pro Arg 1 5 10 15

Pro Gly Gly Pro Thr Val Pro Arg Pro Gly Ala Phe Pro Thr Ala Asp

20 25 30

Ser Gin Met Val Pro Ala Tyr Asp Ser Gly Thr Ala Val Glu Ser Ala 35 40 45

Pro Ala Ala Ser Ser Leu Leu Arg Arg Trp Leu Leu Val Pro Gin Ala

50 55 60

Asp Asp Ser Asp Asp Ala Asp Tyr Ala Gly Asn Asp Asp Ala Glu Trp 65 70 75 80 Ala Asn Ser Pro Pro Ser Glu Gly Gly Gly Lys Ala Pro Glu Ala Pro

85 90 95

His Ala Ala Pro Ala Ser Ala Cys Pro Pro Pro Pro Pro Arg Lys Glu

100 105 110

Arg Gly Gin Gin Arg Pro Leu Pro Xaa 115 120

(2) INFORMATION FOR SEQ ID NO: 61:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 981 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 61:

CCCGGCGGAG AATGAGCCCA CACCCAGATT GTTCACCGCC CCCCATTTCC CCCCCCCCGG 60

GTATACACCN AGGGAAAAGG TTTTTCCCCC CCCCCCCGGA TCAAATTTCC CCCACAAGAA 120 CCGAGTTCCA GGTTAAGTTT AGTTGGGTGC CCTTCCCAGG TTGACGGGGG TCGCCAATGT 180

CCCAGCGGGG GTTGGCGCCC TCAGGGGGGG NGGGGCCAGC CCCCGCGGGC GGTCGCCCAC 240

CAACTTCCAA GCCGCGGCCC GCCGAGGCCA GCACGGTCCC CGGGGGGCCG GTGGCAGACG 300

CCCAGCGTAT CTGCGGGGGC GGGCCCGCGT CCGCGTCGTC GCGCAGCACC AGCGGGGGCG 360 CGTCGCCGTC GGGCTAGAGC AGCGCCCGCG CGCAGAACTC CCGCCGCGGC CCGAGCAGAT 420

CAGCCGGGCC GCCGCGCACG GTGTCGCGCC CCAGCGCCAC GTAGACGGGC CGCAGCGGCG 480

CGCCCAGGCC CCAGCGCGCG CAGGCGCGGT GCGAGTGCGC CTCGTCCTCG CAGAAGTCCG 540

GCGCGCCGGG CGCCATGGCG TCGCCCGCGC CCGAGGCGGC GGCCCGGCCG TCCAGCGCCG 600 GGAGCACGGC GCGGCGGTAC TCGCGCGGGG ACATGGGCAC CAGCGTGTCG GGGCCGAAGC 660

GCGTGCGCAC GCGGTACCGC ACGTTGGCCC CGCGGCAGAG GCGCAGCGGC GGCGCGTCGG 720

GGTACATGCG CGCGTGCGCG GTCTCCACGC GCGCGAATAC CCCGGCCCTA ACACTCTGCC 780

GGATGCCATC ACGGTGCTGC GCTTGTTCCG CGCCCCCGGT CTTCGCACGG CGCTCTGTCT 840

TGGCGGGCTC CTCCTCCCTA GGTTATTTTT GGGTTCTTTC CTCTAAAAAA CCCGGGGCCT 900 CTTTTGGGGG GGCCTTTTCC TCCCGGTCCC CTCCCCGGTT TGTGAACCAA CTAAATATAG 960

GCCGGTGGTT CCCCCAGGCC 981

(2) INFORMATION FOR SEQ ID NO: 62:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 122 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 62:

Val Glu Thr Ala His Ala Arg Met Tyr Pro Asp Ala Pro Pro Leu Arg 1 5 10 15

Leu Cys Arg Gly Ala Asn Val Arg Tyr Arg Val Arg Thr Arg Phe Gly

20 25 30

Pro Asp Thr Leu Val Pro Met Ser Pro Arg Glu Tyr Arg Arg Ala Val 35 40 45

Leu Pro Ala Leu Asp Gly Arg Ala Ala Ala Ser Gly Ala Gly Asp Ala

50 55 60

Met Ala Pro Gly Ala Pro Asp Phe Cys Glu Asp Glu Ala His Ser His 65 70 75 80 Arg Ala Cys Ala Arg Trp Gly Leu Gly Ala Pro Leu Arg Pro Val Tyr

85 90 95

Val Gly Arg Asp Thr Val Arg Gly Gly Pro Ala Asp Leu Leu Gly Pro

100 105 110

Arg Arg Glu Phe Cys Ala Arg Ala Leu Leu 115 120

(2) INFORMATION FOR SEQ ID NO: 63: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 644 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 63:

GCATGCCTGC AGGTCGACTC TAAAGGATCC CCCAGCTGCC TCTCCCNTGG AAGACATATA 60

TCTTCTTGTG CCGGACCAGC TTCAGTGGGG CCAGTGGGCC CTCTAGGGCA ACGGTCACTT 120

GTATCGTGGC ATCCGTGTGC ACTGGCCCCA TTTCCATTGA AAAAATCAGG GTGTCACGGG 180

TTCTGAGGCT GCCATTGAGG CGGTAAAAAA TGGCCCCGTC TAGCAGGTCC TCCTGGGAGA 240

AGGCTGTGAC TGACTGAGTG GCCCAAAGCA ACTGCCCCCA GCGACGGCCG GCTGTGACAT 300 GGTAGTGCAC CTCATCCCCA CTGCGGATGT CAAGGTTGGT GTCCANGTGG AGCTCANCTG 360

TGTCAATGGT GCCCTGACCT CCTTGAGGGA CCACAAGGCC AAAACCGTTG GCCACACGGA 420

TGTAGGGCTC CGAGGCCTGC ACCTCCANCA NCACAGTGGC CTGGTGTTGC CCATCGGACA 480

CACCTGCAGC TGGATCCAGC CATGATCAGC CCAAGTGCAT GAACAGGACT CGCCTCTTTC 540

TGAGGTCCTC CTGGGTGAAG CGGTAAATGG GCCACGTGGG CTCATCCACG GCCACGATAC 600 TGCCAAAAAA GAAGTCCTTG CGGGTCAGGG TACCGANCTC AAA 644

(2) INFORMATION FOR SEQ ID NO: 64:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 151 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 64:

Val Ser Asp Gly Gin His Gin Ala Thr Val Xaa Xaa Glu Val Gin Ala 1 5 10 15

Ser Glu Pro Tyr Ile Arg Val Ala Asn Gly Phe Gly Leu Val Val Pro

20 25 30

Gin Gly Gly Gin Gly Thr Ile Asp Thr Xaa Glu Leu His Xaa Asp Thr 35 40 45 Asn Leu Asp Ile Arg Ser Gly Asp Glu Val His Tyr His Val Thr Ala 50 55 60

Gly Arg Arg Trp Gly Gin Leu Leu Trp Ala Thr Gin Ser Val Thr Ala 65 70 75 80 Phe Ser Gin Glu Asp Leu Leu Asp Gly Ala Ile Phe Tyr Arg Leu Asn

85 90 95

Gly Ser Leu Arg Thr Arg Asp Thr Leu Ile Phe Ser Met Glu Met Gly 100 105 110 Pro Val His Thr Asp Ala Thr Ile Gin Val Thr Val Glu Gly Pro Leu 115 120 125

Ala Pro Leu Lys Leu Val Arg His Lys Lys Ile Tyr Val Phe Xaa Gly

130 135 140

Arg Gly Ser Trp Gly Ile Leu 145 150

(2) INFORMATION FOR SEQ ID NO: 65:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 52 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 65:

Val Glu Leu Xaa Cys Val Asn Gly Ala Leu Thr Ser Leu Arg Asp His 1 5 10 15

Lys Ala Lys Thr Val Gly His Thr Asp Val Gly Leu Arg Gly Leu His

20 25 30

Leu Xaa Xaa His Ser Gly Leu Val Leu Pro Ile Gly His Thr Cys Ser 35 40 45 Trp Ile Gin Pro 50

(2) INFORMATION FOR SEQ ID NO: 66:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 585 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 66: GCTCAATCCT CGAATTCAGA AAACAGTTGC CATTTATCCC TTCTTGTCAG ACTTCAGACG 60

GGTGATTGAG ATTGGTAATA CTAGCGAGGC TTACGACGAA CTTTTCCGTT ATTTCAAGTT 120

TCACGACCCC TTCCATGAAA CAGAGGAGGA AATCATGGCG ACCCTTGCCT ATATCGATGT 180

CAAAAATCTT GCCCATCGTA TCCAAGGTGA GGTTAAAATG ATTACGGGCT TGGACAACAA 240 TGTTTGCTAT CCCATTACCC AGTTTGCGAT TTATAATCGT CTGACCTGCG ATAAAACCTA 300

TCGCATCATG CCTGAGTATG CTCACGAAGC CATGAATGTA TTTGTCAATG ACCAAGTCTA 360

CAACTGGCTC TGTGGAAGTG AGATTCCTTT TAAATATCTA AAATAAGGAG TCGACTCTAA 420

GCACAAAATC TTAAAAATTA CAAACACGCA TAGTATCAGG GGATTAAAAA AACTTGATAC 480

TATGCGTTTT ATCATGGACA TATATTATAA TGAAACAAGA ACAGGACAAA TCGATCCGGA 540 CAGTCCAATC GATTTCTAAC AATGTTTTAA AAGTAAATGT GTCT 585

(2) INFORMATION FOR SEQ ID NO: 67:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 60 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 67:

Met Ile Thr Gly Leu Asp Asn Asn Val Cys Tyr Pro Ile Thr Gin Phe 1 5 10 15

Ala Ile Tyr Asn Arg Leu Thr Cys Asp Lys Tyr Ile Met Pro Glu Tyr

20 25 30

Ala His Glu Ala Met Asn Val Phe Val Asn Asp Gin Val Tyr Asn Trp 35 40 45 Leu Cys Gly Ser Glu Ile Pro Phe Lys Tyr Leu Lys 50 55 60

(2) INFORMATION FOR SEQ ID NO: 68:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1237 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 68: ACTGTATCGA TAAGCTTGAT CCATGGCGGT GGCCGACACA GGGAGGGGCG TCTTCTCCGG 60

AGCGGACGTA GGCGAATCGG AGGACGCGTC CTCGGTCAAG GCCATGAGGC GCCGCCCGGT 120

TAGGGGGGCC CGAACGTCGG GGTCAACCCC CTCGGGGTCT GTCCGCAGGG CGCGTCAAAA 180

CCGCGGGCGG GGTGGGAAGG GGGCGTACGG ACCGTCATCT AGGGCCCCGG GGGCCCAATG 240 GGGTGGCAGG ACCCCGACGT CTTCCGTGGG TCGTGCCATC CGAATAAACG TGCGGCCCGT 300

AATCCCCACC AGCAGGCTCT GGGGAGCAAA ACCGACGCGT GGTAGGTCGC TGGGGGCGGC 360

GGGCGTCTGT GGGGGCAAAC AGCGCTCCCG GAAACGCAGG CCACAAAACC CGGGGTTGGG 420

GGCGGAATAC CATACCGGGG GCACCTATCG CCACGGGCGG CCCGCGGGGA CCGGGGGGAC 480

TCACGGGCCG CCCTCCGCAC GCGCCTCCTG TGGGGGGGCG GTGGGGTTTT CTGCCTATTC 540 CCTTCCTTTC CTCATCCTCT TCCTTCCCTA CTTCCCCCCT TCTCATTTCT CCTCTCTTCT 600

GTTCACCCCT TACTCCGCTT CACTTGCTCT CTCTCTATTC ATTCCGTCCT CTACTTTTCT 660

CGTCCTTTCC TCTCTCTCCC CTCATCTATC TTCTCTTCAT CTCTTTTTCT CTCGCTCCCT 720

CTCTTTCCCA TCTTCCGTTC TTCTCTCACT TTCATATCAT TCTTGCCTCA CCCCGACACT 780

CGCTATTCTC TCTTTCTCGC CACCAATCCT GTGTGTGTTT CTCGTTTTCT TCACACCTCG 840 TTCTATAGCT CACCACATCA TGTGCTTTCT CGTATCTCCT ATCCTCCTTA TCCTTCTCTT 900

TTCTTTCTCT CTCAACCGCT CCCTTCTGTT CCACAGACAC TCTCTCTGCT CTCTCTCATT 960

CTTGCGCTCT TGTATTCACT TCTCATCATT CTTACACTTT TCTCTCTCAT TCGCACCCAT 1020

CTACCGCTAC GTCATTCACA CCGCGATTTT TTCTAGCTCT ACCTATTCCT CCTCGACTTC 1080

TCTGTGCGAC TATACTCCCC TCTTCTTTCT GTCCTACACG TCTGAGATCA CATTGATCTT 1140 CCCTCACCCC TCTGCTCCTG ACTATACCTT ATTCTATTTA TTTCTCGACC CTTCCTTCCC 1200

ATTCTCTATT CTCGACTTCT CTGCACCTCT CCTCAC 1237

(2) INFORMATION FOR SEQ ID NO: 69:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 69:

Met Ala Leu Thr Glu Asp Ala Ser Ser Asp Ser Pro Thr Ser Ala Pro 1 5 10 15

Glu Lys Thr Pro Leu Pro Val Ser Ala Thr Ala Met Asp Gin Ala Tyr

20 25 30

Arg Tyr Ser Xaa Xaa 35

(2) INFORMATION FOR SEQ ID NO: 70: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2057 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 70:

GGCGACACGA GAAGAGAGCA AGGAGGGGAG AGCGACAGAG TAACTACACA TCGGAGCGCA 60

TAATGAAGGA CAGTCATAAG ATGAGAGCAA GAAGAGATGA GCAGAGTCAG AAGATATAGC 120

GACATAGAAG TCAGAGGCGA CACGGGGTAC GTGAGAATGT CGAACGCAGG ACGGGCGGAG 180

GAGAGGAAGG GGGCCCGAGC GCAGAACGAA ACAGGGGAAC ACAGGAGAAC GGAAGGAGCG 240

AGCAAAGGGG AACAGACAGA AGGGCGCGCA NAGCGGAACG CCGCGAGAGC CGAGAGCCAC 300 AACACGGCCA ACGCGGCGAG AGCGACAGGG CAGACAGGGC AACGCGCCAG ACGGAAGCGG 360

CGAGGGACGA AGCGNAGAGC NGGAGAGGCA AGGACAAAGC AAAGGAGGAG GAGAGCGCAC 420

AGAAACGAAG AAGACGAGCG CGACAAGCCA CGGGAACGGA ACGAAACCGA GGCCACGGAG 480

GGAGCAAAGC GAAGGGAGGC CTCCTTCCTC ATCATATTCG GCATCATCAT CGTCTTCATC 540

CGCATATTCC TCTGCGGGCG GGGCTGGTGG GAGCGTCGCG TCCGCGTCCG GCGCTGGGGA 600 GAGACGAGAA ACCTCCCTCG GCCCCCGCGC TGCTGCGCCG CGGGGGCCGA GGAAGTGTGC 660

CAGGAAGACG CGCCACGCGG AGGGCGGCCC CGAGCCCGGG GCCCGCGACC CGGCGCCCGG 720

CCTCACGCGC TACCTGCCCA TCGCGGGGGT CTCGAGCGTC GTGGCCCTGG CGCCTTACGT 780

GAACAAGACG GTCACGGGGG ACTGCCTGCC CGTCCTGGAC ATGGAGACGG GCCACATAGG 840

GGCCTACGTG GTCCTCGTGG ACCAGACGGG GAACGTGGCG GACCTGCTGC GGGCCGCGGC 900 CCCCGCGTGG AGCCGCCGCA CCCTGCTCCC CGAGCACGCG CGCAACTGCG TGAGGCCCCC 960

CGACTACCCG ACGCCCCCCG CGTCGGAGTG GAACAGCCTC TGGATGACCC CGGTGGGCAA 1020

CATGCTCTTT GACCAGGGCA CCCTGGTGGG CGCGCTGGAC TTCCACGGCC TCCGGTCGCG 1080

CCACCCGTGG TCTCGGGAGC AGGGCGCGCC CGCGCCGGCC GGCGACGCCC CCGCGGGCCA 1140

CGGGGAGTAG GGGGAGCTAA CACTCGGCTT GCTGCCCGAA GGGAAGCCGC CCCCCACCGG 1200 ACCACCGGCC GAGGCGCCTC GGGGGCATGG GGATGTGGGG GGGGGGGGAA AACNGGGATC 1260

ATATCCGGAT TGCGGGTGGG ATTGGGGGGG GTATGTTTTT TGTTTNTTTT TGTTTTTTTT 1320

TTTTTNTTTT GGTGTTGGTT TTTTTGGTTT TTGTTTTTTT TTNGGGGGAT TTTTGTTTTT 1380 _{ττττττττττ} TTNTTTTTTC GTTTTTTTTT TTGTGTTTTT NTTTGGTNTT TGGTTTGTTT 1440

TGTGTTTTTT TTTTTTTTNT TNTTTTTTTT TTTTGGGNTT TNTGTTTTTT TTGTTTGTTT 1500 CTTTGTTTTT TTTTNTTTTG TTTCGTGTTT TTCTTTTTTT TTTCCTTCCT TTTCCCCCCG 1560

CTTTCCCCCC CCTNCTCCCC CTCCTCTTCT CTTTCTCTNN TTTTCCTCTT CCCTTTTTCT 1620

TCCCGTCTCC CCTCTGCGTT TCCCTCTCCC TTTTCTTCCC TTCCCGCTTC TCCGTCCCTC 1680

CTCTTTTCCC TCCTTCCTCT TTCTTCCCCT GCTGCCTCCC TCTCTCCTCC TGTCCTTTTC 1740

CCTCTTTTTC CCCTCCCTCT GCCCTTTCTT CCCTTCTCCT CTTCCCTCCC CTCCTTTCTT 1800 TCCTTCCTCG CGTCGTTCCT CCCTCTTCTC TCTCTCTCTC CTCTNGTCCC CCCCCTCTTT 1860

CTCTTCCCCC CTCTTTTTCT CTCCTCTCGT CCTCCTTCCC CCTCATTTTA GCCTCATCCC 1920

CTCCATCCTA TTACTCCTCT ATTCTCCTCT CTCTCCCTCT TCCATCCCTT CCGCTCCTCC 1980

CATTATTCCT CTAAGCTTGC CCTCCTCCAC CTTCTCTCTA TCTCAAGTCC TCCTCCCTCT 2040 CACTATTCGG TTCCCT 2057

(2) INFORMATION FOR SEQ ID NO: 71:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 125 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 71:

Val Ala Pro Tyr Val Asn Lys Thr Val Thr Gly Asp Cys Leu Pro Val 1 5 10 15

Leu Asp Met Gly His Ile Gly Ala Tyr Val Val Leu Val Asp Gin Thr

20 25 30

Gly Asn Val Ala Asp Leu Leu Arg Ala Ala Ala Pro Ala Trp Ser Arg 35 40 45

Arg Thr Leu Leu Pro Glu His Ala Arg Asn Cys Val Arg Pro Pro Asp

50 55 60

Tyr Pro Thr Pro Pro Ala Ser Glu Trp Asn Ser Leu Trp Met Thr Pro 65 70 75 80 Val Gly Asn Met Leu Phe Asp Gin Gly Thr Leu Val Gly Ala Leu Asp

85 90 95

Phe His Gly Leu Arg Ser Arg His Pro Trp Ser Arg Glu Gin Gly Ala

100 105 110

Pro Ala Pro Ala Gly Asp Ala Pro Ala Gly His Gly Glu 115 120 125

(2) INFORMATION FOR SEQ ID NO:72:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1468 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:72:

GCACCGCCCG GAAAGGGATC CCGGGGGGAA CCCCGCCCCC GAGAGGCGAC CGGGGCAGAA 60 CCCCCGGCAC GGTGAGAGGN GACCCCCGGT TATCAGGCCC CCCTTTTTCC CCGACCACCC 120

AGGAGGGGGG TTGGGGGTGT TGCGGGGCGT GGGGTTTGGG GGCGGGGACG CTTGACGGGG 180

CAGACCCCCG CCCCGCTTAA GCGGTCGGGG GACCCCCATG GGCCGTGCGC CGCCCCCCGA 240

CCCTTTGGGG GGGGCGAGGG AGGCAGGGAG CCCTGAGCCC GAGAGCGGGG GACAGGGGGG 300 GGGAGACGAG GGGTAGGAAT CCAAAGGACG CAGACCACCT TTGGTTACGG ACCCCTTTCT 360

CCCCCCCTTC CGAACAAAAA GCAGCGGGCG GGGGGCCGGG GTGAGGGAGG GACACGGGGG 420

ACACGGCACG GGGGTCCCGC CTCACGCCCC GCGCCCTCTA AATCCCCCCC CGTTTCTTTG 480

TCAAGCAGCC CGCCGCCCCG CACGCCTGGG GGATGCTCAA CGACATGCAG TGGCTCGCCA 540

GCAGCGACTC GGAGGAGGAG ACCGAGGTGG GAATCTCTGA CGACGACCTT CACCGCGACT 600 CCACCTCCGA GGCGGGCAGC ACGGACACGG AGATGTTCGA GGCGGGCCTG ATGGACGCGG 660

CCACGCCCCC GGCCCGGCCC CCGGCCGAGC GCCAGGGCAG CCCCACGCCC GCCGACGCGC 720

AGGGATCCTG CGGGGGTGGG CCCGTGGGTG AGGAGGAAGC GGAAGCGGGA GGGGGGGGCG 780

ACGTGTGTGC CGTGTGCACG GACGAGATCG CCCCGCCCCT GCGCTGCCAG AGTTTTCCCT 840

GCCTGCACCC CTTCTGCATC CCGTGCATGA AGACCTGGAT TCCGTTGCGC AACACGTGTC 900 CCCTGTGCAA CACCCCGGTG GCGTACCTGA TAGTGGGCGT GACCGCCAGC GGGTCGTTCA 960

GCACCATCCC GATAGTGAAC GACCCCCGGA CCCGCGTGGA GGCCGAGGCG GCCGTGCGGT 1020

CCGGCACGGC CGTGGACTTT ATCTGGACGG GCAACCCGCG GACGGCCCCG CGCTCCCTGT 1080

CGCTGGGGGG ACACACGGTC CGCGCCCTGT CGCCCACCCC CCCGTGGCCC GGCACGGACG 1140

ACGAGGACGA TGACCCGCCC GACGGTGAGG GCGGGCGGGG GTCTGGCACT GGGCGGGGGT 1200 CCGGCACTGG GCGGGGGTCT GGCACTGGGC GGGGGTCCGG CACTGGGCGG GGGTCTGGCG 1260

GGGGTCAGGC ACTAACCGGG GGTTCCCGTC TCTGTCTCCC TCTGCAACCG GAACTAATTT 1320

CCCGCCCCCC CCCTAATACC TCCCCGCCCG GGGCTGCTGT GCCGGGGCCA CCCCTGGTAA 1380

CTCCACCCCC CCTTTTACCT AACCTGCGCC CCCCGGCCCC CCCCGGGACT ACACTCACCC 1440

GTGGCCCCCC CTTCCTGGGC CGGGGTT 1468

(2) INFORMATION FOR SEQ ID NO: 73:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 319 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 73:

Met Leu Asn Asp Met Gin Trp Leu Ala Ser Ser Asp Ser Glu Glu Glu 1 5 10 15 Thr Glu Val Gly Ile Ser Asp Asp Asp Leu His Arg Asp Ser Thr Ser 20 25 30

Glu Ala Gly Ser Thr Asp Thr Glu Met Phe Glu Ala Gly Leu Met Asp 35 40 45 Ala Ala Thr Pro Pro Ala Arg Pro Pro Ala Glu Arg Gin Gly Ser Pro

50 55 60

Thr Pro Ala Asp Ala Gin Gly Ser Cys Gly Gly Gly Pro Val Gly Glu 65 70 75 80 Glu Glu Ala Glu Ala Gly Gly Gly Gly Asp Val Cys Ala Val Cys Thr

85 90 95

Asp Glu Ile Ala Pro Pro Leu Arg Cys Gin Ser Phe Pro Cys Leu His

100 105 110

Pro Phe Cys Ile Pro Cys Met Lys Thr Trp Ile Pro Leu Arg Asn Thr 115 120 125

Cys Pro Leu Cys Asn Thr Pro Val Ala Tyr Leu Ile Val Gly Val Thr

130 135 140

Ala Ser Gly Ser Phe Ser Thr Ile Pro Ile Val Asn Asp Pro Arg Thr 145 150 155 160 Arg Val Glu Ala Glu Ala Ala Val Arg Ser Gly Thr Ala Val Asp Phe

165 170 175

Ile Trp Thr Gly Asn Pro Arg Thr Ala Pro Arg Ser Leu Ser Leu Gly

180 185 190

Gly His Thr Val Arg Ala Leu Ser Pro Thr Pro Pro Trp Pro Gly Thr 195 200 205

Asp Asp Glu Asp Asp Asp Pro Pro Asp Gly Glu Gly Gly Arg Gly Ser

210 215 220

Gly Thr Gly Arg Gly Ser Gly Thr Gly Arg Gly Ser Gly Thr Gly Arg 225 230 235 240 Gly Ser Gly Thr Gly Arg Gly Ser Gly Gly Gly Gin Ala Leu Thr Gly

245 250 255

Gly Ser Arg Leu Cys Leu Pro Leu Gin Pro Glu Leu Ile Ser Arg Pro

260 265 270

Pro Pro Asn Thr Ser Pro Pro Gly Ala Ala Val Pro Gly Pro Pro Leu 275 280 285

Val Thr Pro Pro Pro Leu Leu Pro Asn Leu Arg Pro Pro Ala Pro Pro

290 295 300

Gly Thr Thr Leu Thr Arg Gly Pro Pro Phe Leu Gly Arg Gly Phe 305 310 315

(2) INFORMATION FOR SEQ ID NO: 74:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 620 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 74:

AAAACGCACG AGTATTGCAC GAATAACCAA CCAAACAACC ACTCAGACCA TGTGGATCCA 60 TACCCTTACT TGGCAAAATG GGGCATTAGC CGTGAGCAGT TTAAGCATGA TATTGAGAAC 120

GGCTTGACGA TTGAAACAGG CTGGCAGAAG AATGACACTG GCTACTGGTA CGTACACTCA 180

GACGGCTCTT ATCCAAAAGA CAAGTTTGAG AAAATCAATG GCACTTGGTA CTACTTTGAC 240

AGTTCAGGCT ATATGCTTGC AGACCGCTGG AGGAAGCACA CAGACGGCAA CTGGTACTGG 300

TTCGACAACT CAGGCGAAAT GGCTACAGGC TGGAAGAAAA TCGCTGATAA GTGGTACTAT 360 TTCAACGAAG AAGGTGCCAT GAAGACAGGC TGGGTCAAGT ACAAGGACAC TTGGTACTAC 420

TTAAACGCTA AAGAAGGCGC CATGGTATCA AATGCCTTTA TCCACTCAGC CGGACGGAAC 480

AGGCTGGTAC TACCTCAAAC CAGACCGAAC ACTGGCAGAC AAGCCAGAAT TCACAGTAGA 540

CCCAGATGGC TTGATTACGT TAAAATAATA ATGGAATGTC TTTCAAATCA AAACCCCGCA 600

TATTATTAGG TCTTGAAAA 620

(2) INFORMATION FOR SEQ ID NO: 75:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 116 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 75:

Met Leu Ala Asp Arg Trp Arg Lys His Thr Asp Gly Asn Trp Tyr Trp 1 5 10 15 Phe Asp Asn Ser Gly Glu Met Ala Thr Gly Trp Lys Lys Ile Ala Asp 20 25 30

Lys Trp Tyr Tyr Phe Asn Glu Glu Gly Ala Met Lys Thr Gly Trp Val

35 40 45

Lys Tyr Lys Asp Thr Trp Tyr Tyr Leu Asn Ala Lys Glu Gly Ala Met 50 55 60

Val Ser Asn Ala Phe Ile His Ser Ala Gly Arg Asn Arg Leu Val Leu 65 70 75 80

Pro Gin Trp Asn Thr Gly Arg Gin Ala Arg Ile His Ser Arg Pro Arg 85 90 95 Trp Leu Asp Tyr Val Lys Ile Ile Met Glu Cys Leu Ser Asn Gin Asn 100 105 110

Pro Ala Tyr Tyr 115 (2) INFORMATION FOR SEQ ID NO: 76:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2695 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 76:

GGGAGAGAAG AGAGAGAGAG AGAGAGAAGG AGTAGGAGAG CGAGGAGAGG AGAATAAGGA 60

GTGAATGGAA GCAGTAAGCT AGATAGGCAG AGAGAGAGAG AACGGAGAGT AGGAGTGGAA 120 GAAGTGGAAG TTGAGAACGA CAAGGAGAGA GAAAGGAAGA AAAGTAGAGA GACTAGAGAA 180

TAGAAGAGGA GAACAGAGAG GTAGGAGAAA GAGGAAAAGA AGAGAGAGAG AAGGCAGCGA 240

GAAAGAGAGG AGCAGGCGGA CAAGGAGAAG AGGGAGGAAG AGGAAAAGAG GAAGAGAGAA 300

GAAGAATGGT GGAGAGAGAA GAGGAAAGAG CACCCGCGCC ACCGAGGATT GGGAGATGAA 360

TTAGGGGCCC CTAAGAGGAC CGAAGACCCG GGCGTAGATT ATTCGCCCCG GAGGGCAAGG 420 GAGGTCGACC GCAAAGTAAA TACACCACCA GGGAGGAGGG AAATATGAAC GCCGGCGGAG 480

ACCCGGGGCC CTAGATACTG GTGAAGACGA TCAAAAGTAT GGATATGCCG GTCGCCACCA 540

GCTTTTTGGC CCCGGACGGA ACGCCGCTGC AGTACGCGCT ATGCTTCCCG GCCGTCACCG 600

ACAAACTCGG CGCGCTGCTG ATGCGTCCCG AGGCGGCCTG CGTGCGGCCC CCGCTTCCGA 660

CGGACGTCCT CGAATCGGCC CCGACGGTCA CGGCCATGTA CGTGCTGACC GTCGTGAACC 720 GGCTCCAGCT GGCCCTCAGC GACGCCCAGG CCGCCAACTT TCAGCTGTTC GGTCGCTTCG 780

TGCGCCATCG CCAGGCGACG TGGGGCGCCT CGATGGACGC GGCGGCCGAG CTGTACGTCG 840

CCCTCGTCGC CACCACCCTC ACGCGCGAGT TTGGGTGTCG CTGGGCCCAG CTGGGCTGGG 900

CGTCCGGAGC GGCGGCGCCG CGTCCGCCGC CGGGCCCCCG GGGGTCCCAG CGCCACTGCG 960

TCGCCTTCAA CGAGAACGAC GTGCTGGTCG CGCTGGTGGC CGGCGTTCCG GAACACATCT 1020 ACAACTTCTG GCGCCTGGAC CTCGTTCGCC AGCACGAGTA CATGCACCTC ACCCTCGAAC 1080

GCGCGTTCGA GGACGCAGCG GAGTCCATGC TGTTCGTCCA GCGCCTGACC CCGCATCCCG 1140

ACGCCCGCAT CCGCGTGTTG CCGACGTTTT TGGACGGAGG CCCCCCGACC CGGGGCCTCC 1200

TGTTCGGCAC GCGGCTGGCC GACTGGCGCC GGGGCAAGCT GTCCGAAACC GACCCGCTGG 1260

CGCCCTGGCG CTCGGCCTTG GAGCTCGGGA CCCAGCGCCG GGACGCCCCG GCGCTCGGGA 1320 AGCTCAGTCC GGCCCAGGCC CTGGCGGCGG TGAGCGTCCT CGGGCGCATG TGTCTGCCGA 1380

GCGCCGCTTT GGCCGCGCTG TGGACCTGCA TGTTTCCCGA CGACTACACC GAGTACGACA 1440

GCTTCGACGC CCTCCTGGCC GCACGCCTGG AGTCTGGCCA GACGCTCGGC CCGGCGGGGG 1500

GGCGCGAGGC GTCCCTCCCC GAGGCCCCCC ACGCCCTCTA CCGACCCACG GGCCAGCACG 1560

TGGCCGTGCT GGCCGCCGCG ACCCACCGCA CCCCCGCCGC GCGCGTTACG GCCATGGACC 1620 TGGTTCTGGC CGCGGTGCTC CTCGGCGCGC CCGTCGTGGT GGCGCTCCGC AACACCACGG 1680

CCTTCTCCCG CGAGTCGGAA CTGGAACTGT GCCTGACGCT CTTCGACTCG CGCCCCGGCG 1740

GGCCGGACGC CGCCCTGCGC GACGTCGTGT CGTCCGACAT CGAGACGTGG GCCGTCGGCC 1800

TCCTCCACAC CGATCTCAAC CCGATCGAAA ACGCGTGTCT GGCGGCGCAG CTCCCGCGCC 1860 TGTCGGCGCT CATCGCCGAG CGCCCTCTCG CCGACGGGCC CCCGTGCCTG GTCCTCGTGG 1920

ACATCTCCAT GACCCCGGTC GCGGTCTTGT GGGAAGCCCC GGAGCCCCCC GGCCCCCCTG 1980

ACGTGCGGTT TGTGGGCAGC GAGGCCACCG AGGAGCTTCC GTTTGTGGCT ACCGCGGGGG 2040

ACGTTCTTGC GGCGAGCGCC GCCGACGCGG ACCCCTTCTT CGCGCGGGCC ATCCTCGGGC 2100 GGCCCTTCGA CGCCTCCCTC CTGACGGGGG AGCTGTTCCC GGGACACCCG GTTTACCAGC 2160

GCCCCCTCGC CGACGAGGCA GGTCCCTCTG CCCCGACCGC CGCCCGCGAC CCGCGGGACC 2220

TTGCGGGGGG GGATGGCGGA TCGGGTCCCG AGGACCCCGC TGCCCCCCCC GCGCGGCAGG 2280

CGGACCCGGG GGTCCTCGCC CCCACTTTCC TCACCGACGC CACCACCGGC GAGCCCGTCC 2340

CCCCTCGCAT GTGGGCCTGG ATCCACGGCC TGGAGGAGCT GGCGTCCGAG GACGCCGGCG 2400 GCCCCACGCC CAATCCGGCC CCGGCCTTAC TTCCCCCCCC CGCCACCGAT CAGTCCGTCC 2460

CCACGTCCCA GTACGCACCG CGGCCCATCG GGCCGGCAGN TACGGCTCGC GAAACACGAC 2520

CGAGTGTCCC GCCTCAACAA AACACGGGGC GCGTGCCCGT GGCCCCTCGG GANGACCCAC 2580

GGCCCTCGCC ACCCACACCG AGTCCCCCCG CGGATGCCGC GGTTCCTCCC CCGGCCTTTT 2640

CCGGGTTTGC CGCCGCTTTT TCCGCCGCCG TGCCGCGCGT GCGCAGATCC CGCC 2695

(2) INFORMATION FOR SEQ ID NO: 77:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 718 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 77:

Val Lys Thr Ile Lys Ser Met Asp Met Pro Val Ala Thr Ser Phe Leu

1 5 10 15

Ala Pro Asp Gly Thr Pro Leu Gin Tyr Ala Leu Cys Phe Pro Ala Val 20 25 30

Thr Asp Lys Leu Gly Ala Leu Leu Met Arg Pro Glu Ala Ala Cys Val 35 40 45

Arg Pro Pro Leu Pro Thr Asp Val Leu Glu Ser Ala Pro Thr Val Thr

50 55 60

Ala Met Tyr Val Leu Thr Val Val Asn Arg Leu Gin Leu Ala Leu Ser

65 70 75 80

Asp Ala Gin Ala Ala Asn Phe Gin Leu Phe Gly Arg Phe Val Arg His

85 90 95

Arg Gin Ala Thr Trp Gly Ala Ser Met Asp Ala Ala Ala Glu Leu Tyr 100 105 110

Val Val Ala Thr Thr Leu Thr Arg Glu Phe Gly Cys Arg Trp Ala Gin 115 120 125 Leu Gly Trp Ala Ser Gly Ala Ala Ala Pro Arg Pro Pro Pro Gly Pro

130 135 140

Arg Gly Ser Gin Arg His Cys Val Ala Phe Asn Glu Asn Asp Val Leu

145 150 155 160

Val Val Ala Gly Val Pro Glu His Ile Tyr Asn Phe Trp Arg Leu Asp

165 170 175

Leu Val Arg Gin His Glu Tyr Met His Leu Thr Leu Glu Arg Ala Phe

180 185 190

Glu Asp Ala Ala Glu Ser Met Leu Phe Val Gin Arg Leu Thr Pro His 195 200 205

Pro Asp Ala Arg Ile Arg Val Leu Pro Thr Phe Leu Asp Gly Gly Pro

210 215 220

Pro Thr Arg Gly Leu Leu Phe Gly Thr Arg Leu Ala Asp Trp Arg Arg

225 230 235 240

Gly Lys Leu Ser Glu Thr Asp Pro Leu Ala Pro Trp Arg Ser Ala Leu

245 250 255

Glu Leu Gly Thr Gin Arg Arg Asp Ala Pro Ala Leu Gly Lys Leu Ser

260 265 270

Pro Ala Gin Ala Ala Val Ser Val Leu Gly Arg Met Cys Leu Pro Ser 275 280 285

Ala Ala Ala Leu Trp Thr Cys Met Phe Pro Asp Asp Tyr Thr Glu Tyr

290 295 300

Asp Ser Phe Asp Ala Leu Leu Ala Ala Arg Leu Glu Ser Gly Gin Thr

305 310 315 320

Leu Gly Pro Ala Gly Gly Arg Glu Ala Ser Leu Pro Glu Ala Pro His

325 330 335

Ala Leu Tyr Arg Pro Thr Gly Gin His Val Ala Val Leu Ala Ala Ala

340 345 350

Thr Thr Pro Ala Ala Arg Val Thr Ala Met Asp Leu Val Leu Ala Ala 355 360 365

Val Leu Leu Gly Ala Pro Val Val Val Arg Asn Thr Thr Ala Phe Ser

370 375 380

Arg Glu Ser Glu Leu Glu Leu Cys Leu Thr Leu Phe Asp Ser Arg Pro

385 390 395 400

Gly Gly Pro Asp Ala Ala Leu Arg Asp Val Val Ser Ser Asp Ile Glu

405 410 415

Thr Trp Ala Val Gly Leu Leu His Thr Asp Leu Asn Pro Ile Glu Asn

420 425 430

Ala Cys Leu Ala Ala Gin Leu Pro Arg Leu Ser Ala Leu Ile Ala Glu 435 440 445

Arg Pro Leu Ala Asp Gly Pro Pro Cys Leu Val Leu Val Asp Ile Ser

450 455 460

Met Thr Pro Val Ala Val Leu Trp Glu Ala Pro Glu Pro Pro Gly Pro 465 470 475 480

Pro Asp Val Arg Phe Val Gly Ser Glu Ala Thr Glu Glu Leu Pro Phe

485 490 495

Val Ala Thr Ala Gly Asp Val Leu Ala Ala Ser Ala Ala Asp Ala Asp 500 505 510

Pro Phe Phe Ala Arg Ala Ile Leu Gly Arg Pro Phe Asp Ala Ser Leu

515 520 525

Leu Thr Gly Glu Leu Phe Pro Gly His Pro Val Tyr Gin Arg Pro Leu

530 535 540 Ala Asp Glu Ala Gly Pro Ser Ala Pro Thr Ala Ala Arg Asp Pro Arg

545 550 555 560

Asp Leu Ala Gly Gly Asp Gly Gly Ser Gly Pro Glu Asp Pro Ala Ala

565 570 575

Pro Pro Ala Arg Gin Ala Asp Pro Gly Val Leu Ala Pro Thr Phe Leu 580 585 590

Thr Asp Ala Thr Thr Gly Glu Pro Val Pro Pro Arg Met Trp Ala Trp

595 600 605

Ile His Gly Leu Glu Glu Leu Ala Ser Glu Asp Ala Gly Gly Pro Thr

610 615 620 Pro Asn Pro Ala Pro Ala Leu Leu Pro Pro Pro Ala Thr Asp Gin Ser

625 630 635 640

Val Pro Thr Ser Gin Tyr Ala Pro Arg Pro Ile Gly Pro Ala Xaa Thr

645 650 655

Ala Arg Glu Trp Ser Val Pro Pro Gin Gin Asn Thr Gly Arg Val Pro 660 665 670

Val Ala Pro Arg Xaa Asp Pro Arg Pro Ser Pro Pro Thr Pro Ser Pro

675 680 685

Pro Ala Asp Ala Ala Val Pro Pro Pro Ala Phe Ser Gly Phe Ala Ala 690 695 700 Ala Phe Ser Ala Ala Val Pro Arg Val Arg Arg Ser Arg Arg 705 710 715

(2) INFORMATION FOR SEQ ID NO: 78:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2842 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 7! GGGGGGAGGG AAACAAGCCC GATAGAGCGC TAATGAGAAG GGAGGATATA ATGAGGGACA 60

TTGGGGGAGG GAAGGTAACA GGAAGGTTTT AGGAGCCCAA GAAGACCGGA GGACCCCCAA 120

GACATTGGAG GAAATGGCCG AGGCCGTTAA GGAGGGAAGA GGTTCAGACA TCCCGGCCCC 180

CACCCGTACA AGAGCCCAGG AGCCACCAAG CCCCGGGAGC GGGAAAACAA AAAGCCGCCC 240 AAGCGGCCCG AGGCGACCCC GCCCCCCGAC GCCAACGCGA CCGTCGCCGC CGGCCACGCC 300

ACGCTGCGCG CGCACCTGCG GGAAATCAAG GTCGAGAACG CCGATGCCCA GTTTTACGTG 360

TGCCCGCCCC CGACGGGCGC CACGGTGGTG CAGTTTGAGC AGCCGCGCCG CTGCCCGACG 420

CGCCCGGAGG GGCAGAACTA CACGGAGGGC ATCGCGGTGG TCTTCAAGGA GAACATCGCC 480

CCGTACAAAT TCAAGGCCAC CATGTACTAC AAAGACGTGA CCGTGTCGCA GGTGTGGTTC 540 GGCCACCGCT ACTCCCAGTT TATGGGGATA TTCGAGGACC GCGCCCCCGT TCCCTTCGAG 600

GAGGTGATCG ACAAGATTAA CGCCAAGGGG GTCTGCCGCT CCACGGCCAA GTACGTGCGG 660

AACAACATGG AGACCACCGC GTTTCACCGG GACGACCACG AGACCGACAT GGAGCTCAAG 720

CCGGCGAAGG TCGCCACGCG CACGAGCCGG GGGTGGCACA CCACCGACCT CAAGTACAAC 780

CCCTCGCGGG TGGAGGCGTT CCATCGGTAC GGCACGACGG TCAACTGCAT CGTCGAGGAG 840 GTGGACGCGC GGTCGGTGTA CCCGTACGAT GAGTTTGTGT TGGCGACGGG CGACTTTGTG 900

TACATGTCCC CGTTTTACGG CTACCGGGAG GGGTCGCACA CCGAGCACAC CAGCTACGCC 960

GCCGACCGCT TCAAGCAGGT CGACGGCTTC TACGCGCGCG ACCTCACCAC GAAGGCCCGG 1020

GCCACGTCGC CGACGACCCG CAACTTGCTG ACGACCCCCA AGTTTACCGT GGCCTGGGAC 1080

TGGGTGCCGA AGCGACCGGC GGTCTGCACC ATGACCAAGT GGCAGGAGGT GGACGAGATG 1140 CTCCGCGCCG AGTACGGCGG CTCCTTCCGC TTCTCCTCCG ACGCCATCTC GACCACCTTC 1200

ACCACCAACC TGACCCAGTA CTCGCTCTCG CGCGTCGACC TGGGCGACTG CATTGGCCGG 1260

GATGCCCGCG AGGCCATCGA CCGCATGTTT GCGCGCAAGT ACAACGCCAC GCACATCAAG 1320

GTGGGCCAGC CGCAGTACTA CCTGGCCACG GGGGGCTTCC TCATCGCGTA CCAGCCCCTC 1380

CTCAGCAACA CGCTCGCCGA GCTGTACGTG CGGGAGTACA TGCGGGAGCA GGACCGCAAG 1440 CCCCGGAATG CCACGCCCGC GCCACTGCGG GAGGCGCCCA GCGCCAACGC GTCCGTGGAG 1500

CGCATCAAGA CCACCTCCTC GATCGAGTTC GCCCGGCTGC AGTTTACGTA TAACCACATA 1560

CAGCGCCACG TGAACGACAT GCTGGGGCGC ATCGCCGTCG CGTGGTGCGA GCTGCAGAAC 1620

CACGAGCTGA CTCTCTGGAA CGAGGCCCGC AAGCTCAACC CCAACGCCAT CGCCTCCGCC 1680

ACCGTCGGCC GGCGGGTGAG CGCGCGCATG CTCGGAGACG TCATGGCCGT CTCCACGTGC 1740 GTGCCCGTCG CCCCGGACAA CGTGATCGTG CAGAACTCGA TGCGCGTCAG CTCGCGGCCG 1800

GGGACGTGCT ACAGCCGCCC CCTGGTCAGC TTTCGGTACG AAGACCAGGG CCCGCTGATC 1860

GAGGGGCAGC TGGGCGAGAA CAACGAGCTG CGCCTCACCC GCGACGCGCT CGAGCCGTGC 1920

ACCGTGGGCC ACCGGCGCTA CTTCATCTTC GGCGGGGGCT ACGTGTACTT CGAGGAGTAC 1980

GCGTACTCTC ACCAGCTGAG TCGCGCCGAC GTCACCACCG TCAGCACCTT CATCGACCTG 2040 AACATCACCA TGCTGGAGGA CCACGAGTTT GTGCCCCTGG AGGTCTACAC GCGCCACGAG 2100

ATCAAGGACA GCGGCCTGCT GGACTACACG GAGGTCCAGC GCCGCAACCA GCTGCACGAC 2160

CTGCGCTTTG CCGACATCGA CACGGTCATC CGCGCCGACG CCAACGCCGC CATGTTCGCG 2220

GGGCTGTGCG CGTTCTTCGA GGGGATGGGG GACTTGGGGC GCGCGGTCGG CAAGGTAGTC 2280

ATGGGAGTAG TGGGGGGCGT GGTGTCGGCC GTCTCGGGCG TGTCCTCCTT TATGTCCAAC 2340 CCCTTCGGGG CGCTTGCCGT GGGGCTGCTG GTCCTGGCCG GCCTGGTCGC GGCCTTCTTC 2400

GCCTTCCGCT ACGTCCTGCA ACTGCAACGC AATCCCATGA AGGCCCTGTA TCCGCTCACC 2460

ACCAAGGAAC TCAAGACTTC CGACCCCGGG GGCGTGGGCG GGGAGGGGGA GGAAGGCGCG 2520

GAGGGGGGCG GGTTTGACGA GGCCAAGTTG GCCGAGGCCC GAGAAATGAT CCGATATATG 2580 GNTTTGGTGT CGGCCATGGA GCGCACGGAA CACAAGGCCA GAAAGAAGGG CACGAGCGCC 2640

CTGCTCAGCT CCAAGGTCAC CAACATGGTT CTGCGCAAGC GCAACAAAGC CAGGTACTCT 2700

CCGCTCCACA ACGAGGACGA GGCCGGAGAC GAAGACGAGC TCTAAGGGAG GGGAGGGGAG 2760

CTGGGCTTGT GTATAAATAA AAAGACACCG ATGTTCAAAA ATACACATGA CTTCTNGGTA 2820 TGTNTGGGTA CCGAGCTCGA A 2842

(2) INFORMATION FOR SEQ ID NO: 79:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 787 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 79:

Val Cys Pro Pro Pro Thr Gly Ala Thr Val Val Gin Phe Glu Gin Pro 1 5 10 15

Arg Arg Cys Pro Trp Glu Gly Gin Asn Tyr Thr Glu Gly Ile Ala Val

20 25 30

Val Phe Lys Glu Asn Ile Ala Pro Tyr Lys Phe Lys Ala Thr Met Tyr 35 40 45 Tyr Lys Asp Val Thr Val Ser Gin Val Trp Phe Gly His Arg Tyr Ser 50 55 60

Gin Phe Met Gly Ile Phe Glu Asp Arg Ala Pro Val Pro Phe Glu Glu 65 70 75 80

Val Ile Asp Lys Ile Asn Ala Lys Gly Val Cys Arg Ser Thr Ala Lys 85 90 95

Tyr Val Arg Asn Asn Met Thr Ala Phe His Arg Asp Asp His Glu Thr

100 105 110

Asp Met Glu Leu Lys Pro Ala Lys Val Ala Thr Arg Thr Ser Arg Gly 115 120 125 Trp His Thr Thr Asp Leu Lys Tyr Asn Pro Ser Arg Val Glu Ala Phe 130 135 140

His Arg Tyr Gly Thr Thr Val Asn Cys Ile Val Glu Glu Val Asp Ala 145 150 155 160

Arg Ser Val Tyr Pro Tyr Asp Glu Phe Val Leu Ala Thr Gly Asp Phe 165 170 175

Val Tyr Met Ser Pro Phe Tyr Gly Tyr Arg Glu Gly Ser His Thr Glu

180 185 190

His Thr Ser Tyr Ala Ala Asp Arg Phe Lys Gin Val Asp Gly Phe Tyr 195 200 205

Ala Arg Asp Leu Thr Thr Lys Ala Arg Ala Thr Ser Pro Thr Thr Arg 210 215 220

Asn Leu Leu Thr Thr Pro Lys Phe Thr Val Ala Trp Asp Trp Val Pro

225 230 235 240

Lys Arg Pro Ala Val Cys Thr Met Thr Lys Trp Gin Glu Val Asp Glu 245 250 255

Met Leu Arg Ala Glu Tyr Gly Gly Ser Phe Arg Phe Ser Ser Asp Ala 260 265 270

Ile Ser Thr Thr Phe Thr Thr Asn Leu Thr Gin Tyr Ser Leu Ser Arg 275 280 285

Val Asp Leu Gly Asp Cys Ile Gly Arg Asp Ala Arg Glu Ala Ile Asp

290 295 300

Arg Met Phe Ala Arg Lys Tyr Asn Ala Thr His Ile Lys Val Gly Gin

305 310 315 320

Pro Gin Tyr Tyr Leu Ala Thr Gly Gly Phe Leu Ile Ala Tyr Gin Pro 325 330 335

Leu Leu Ser Asn Thr Leu Ala Glu Leu Tyr Val Arg Glu Tyr Met Arg 340 345 350

Glu Gin Asp Arg Lys Pro Arg Asn Ala Thr Pro Ala Pro Leu Arg Glu 355 360 365

Ala Pro Ser Ala Asn Ala Ser Val Glu Arg Ile Lys Thr Thr Ser Ser 370 375 380

Ile Glu Phe Ala Arg Leu Gin Phe Thr Tyr Asn His Ile Gin Arg His

385 390 395 400

Val Asn Asp Met Leu Gly Arg Ile Ala Val Ala Trp Cys Glu Leu Gin

405 410 415

Asn His Glu Leu Thr Leu Trp Asn Glu Ala Arg Lys Leu Asn Pro Asn 420 425 430

Ala lie Ala Ser Ala Thr Val Gly Arg Arg Val Ser Ala Arg Met Leu 435 440 445

Gly Asp Val Met Ala Val Ser Thr Cys Val Pro Val Ala Pro Asp Asn 450 455 460

Val lie Val Gin Asn Ser Met Arg Val Ser Ser Arg Pro Gly Thr Cys

465 470 475 480

Arg Pro Leu Val Ser Phe Arg Tyr Glu Asp Gin Gly Pro Leu Ile Glu 485 490 495

Gly Gin Leu Gly Glu Asn Asn Glu Leu Arg Leu Thr Arg Asp Ala Leu 500 505 510

Glu Pro Cys Thr Val Gly His Arg Arg Tyr Phe Ile Phe Gly Gly Gly 515 520 525

Tyr Val Tyr Phe Glu Glu Tyr Ala Tyr Ser His Gin Leu Ser Arg Ala 530 535 540 Asp Val Thr Thr Val Ser Thr Phe Ile Asp Leu Asn Ile Thr Met Leu

545 550 555 560

Glu Asp His Glu Phe Val Pro Leu Glu Val Tyr Thr Arg His Glu Ile

565 570 575 Lys Asp Ser Gly Leu Leu Asp Tyr Thr Glu Val Gin Arg Arg Asn Gin

580 585 590

Leu His Asp Leu Arg Phe Ala Asp Ile Asp Thr Val Ile Arg Ala Asp

595 600 605

Ala Asn Ala Ala Met Phe Ala Gly Leu Cys Ala Phe Phe Glu Gly Met 610 615 620

Gly Asp Leu Gly Arg Ala Val Gly Lys Val Val Met Gly Val Val Gly

625 630 635 640

Gly Val Val Ser Ala Val Ser Gly Val Ser Ser Phe Met Ser Asn Pro

645 650 655 Phe Gly Ala Val Gly Leu Leu Val Leu Ala Gly Leu Val Ala Ala Phe

660 665 670

Phe Ala Phe Arg Tyr Val Leu Gin Leu Gin Arg Asn Pro Met Lys Ala

675 680 685

Leu Tyr Pro Leu Thr Thr Lys Glu Leu Lys Thr Ser Asp Pro Gly Gly 690 695 700

Val Gly Gly Glu Gly Glu Glu Gly Ala Glu Gly Gly Gly Phe Asp Glu

705 710 715 720

Ala Lys Leu Ala Glu Ala Arg Glu Met Ile Arg Tyr Met Xaa Leu Val

725 730 735 Ser Ala Met Glu Arg Thr Glu His Lys Ala Arg Lys Lys Gly Thr Ser

740 745 750

Ala Leu Leu Ser Ser Lys Val Thr Asn Met Val Leu Arg Lys Arg Asn

755 760 765

Lys Ala Arg Tyr Ser Pro Leu His Asn Glu Asp Glu Ala Gly Asp Glu 770 775 780

Asp Glu Leu 785

(2) INFORMATION FOR SEQ ID NO: 80:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4290 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 80: GAGGAAGAGA GGGGGGAGGG GAAGAGAAAA GAGAAAAGGA AGAGGAGGGA GGAGAAGAAG 60

GGAAGGGTAA GAGGGGAAGA AGGGAANAAG GAAAAAGGAG TGTGAGAGGA GGTAGGAGAT 120

GAAGAGAAAA GAGGGGGAGA GAGAAGGGAA AAAGAAGTGG AAGGGAGGGA GAAATAGGGG 180 AGAGGAGAAA AGTAAGATTA GGAGGTGGAG AGGGGAGGAA GAGGAATAAG ATAGGTAGAG 240

TAGGTGAAGG TGGGAGAAGG AGAGATGTAG GGATAGGGAA AAGGGGGGGG AGGGGAGATG 300

AGATAGAGAG GAGGGGGGAA AGGAAGGGGA TGAAGAGGAG GGGAGAGGGA GGGGGGGAGA 360

AAGGAGGTGA GGGGGGAGGG GGAAGAGGGG GGAGGGGAGG GGGGAGAGAA GAANAGAAAA 420

NNAAGNNNCC CCGGCCGCGT CCCCGNTGGA GCCCCTGGGG GACCCGACCC TGTGGCGGGC 480 GCTGTATGCG TGCGTCCTGG CGGCCCTGGA GCGCCAGACG GGGCCGGTGG CCCTCTTCGT 540

CCCGCTGCGC CTGGGCTGGG ACCCGCAGAC GGGTCTGGTC GTGAGGGTCG AAAGGGCGTC 600

GTGGGGCCCG CCGGCCGCTC CTCGCGCCGC CCTCCTGGAC GTGGAGGCCA AGGTCAACTT 660

CAACCCGCTG GCCCTGGCCG CGCGCGTCGC CGAGCACCCC GGCGCGCGGT TGGCGTGGGC 720

GCGCCTGGCC GCCATTCGCA ACAGCCCCCA GTGCGCGTCC TCCGCCTCGC TCGCCGTCAC 780 CATCACGACG AGGACCGCGC GTTTCGCGCG CGAATACACC ACCCTGGCGT TTCCGCCGAC 840

CAGCAAGGAG GGCGCCTTCG CGGACCTGGT CGAGGTGTGC GAGGTATGCC TGCGGCCCCG 900

CGGACACCCG CATCGGGTCA CGGCGCGGGT GCTGCTGCCG CGCGGCTACA ACTACTTCGT 960

GAGCGCCGGC GACGGGTTCT CCGCCCCGGC GCTGGTCGCC CTCTTCCGGC AGTGGCATAC 1020

CACGGTCCAC CCCGCCCCCG GAGCCCTGGC CCCCGTCTTC GCTTTTCTGG GGCCCGGGTT 1080 TGAGGTCCGG GGAGGGCCCC TCCAATACTT TGCCGTGCTG GGATTTCCGG GCTGGCCCCC 1140

CTTTACCGTG CCGGCCGCCG CCGCCGCCGA ATCGGTGCGT GACCTGCTGC GGGGCGCCGC 1200

GTGCACCCAT CCCCTTTGCC CTGGGGGCCC TGGCCCGCGG TGGGCGCCTA GGTCTTCCTG 1260

CCCCCGCGGG CATGGCCGGC CGTGGCCTCG GAGGCGGCCG GCCGCCTCCT GCCCGCCTTT 1320

CGGGAAGCGG TGGCGCGGTG GCACCCCACG GCCACCACCA TCCAACTACT CGACCCCCCG 1380 GCGGCCGTCG GGCCGGTCTG GACGGCGCGG TTTTGTTTCT CCGGGCTCCA GGCCCAGCTC 1440

CTGGCCGCCC TCGCGGGCCT CGGGGAGGCC GGGCTGCCGG AAGCCCGGGG GCGGGCGGGC 1500

CTGGAAAGGC TGGACGCGCT GGTGGCGGCC GCCCCCTCGG AGCCCTGGGC CCGGGCCGTG 1560

CTGGAGCGCC TGGTGCCGGA CGCGTGCGAC GCCTGCCCCG CGCTCCGGCA GCTGCTCGGC 1620

GGGGTCATGG CCGCCGTCTG CCTGCAGATC GAGCAGACGG CCAGCTCGGT GAAGTTTGCG 1680 GTCTGCGGCG GCACCGGGGC TGCGTTCTGG GGGCTGTTCA ACGTGGACCC CGGGGACGCG 1740

GACGCCGCGC ACGGCGCGAT CCATGACGCC CGCCGGGCCC TCGAGGCGTC CGTGCGCGCC 1800

GTACTTTCGG CCAACGGCAT ACGCCCGCGC CTCGCCCCCT CCCTGGCGCT AGAGGGCGTC 1860

TACACCCACG TCGTCACCTG GAGCCAGACC GGGGCGTGGT TCTGGAACTC CCGCGATGAC 1920

ACCGACTTCC TGCAGGGATT TCCTCTCCGC GGGCCCGCGT ACGCCGCGGC GGCCGAGGTT 1980 ATGCGCGACG CGCTGAGACG AATCCTCCGG CGGCCGGCCG CCGGCCCGCC GGAGGAGGCC 2040

GTGTGCGCGG CCCGGGGCAT CATGGAGGAC GCCTGTGACC GCTTTGTCCT GGATGCCTTC 2100

GGGAGGCGTC TGGACGCGGA GTACTGGAGC GTTCTGACCC CCCCGGGCGA GGCCGACGAC 2160

CCCCTGCCCC AAACGGCCTT CCGCGGAGGC GCCCTGCTGG ACGCGGAGCA ATACTGGAGA 2220

CGCGTCGTGC GCGTATGTCC CGGGGGCGGG GAGTCGGTCG GCGTCCCCGT GGATCTGTAC 2280 CCGCGGCCCT TGGTGCTCCC CCCCGTGGAC TGCGCCCATC ACCTGCGCGA GATCCTGCGC 2340

GAGATTCAAC TGGTGTTTAC GGGGGTTCTG GAAGGCGTGT GGGGCGAGGG CGGGAGCTTT 2400

GTGTACCCTT TCGAGGAAAA GATGCGGTTT CTGTTTCCCT GAATTTGGTC AATAAACTGG 2460

GGCCCCGTGC TCCAACTTAC CCCCGCGTGT GCGCGCGTCC GTATTTACTG ACACGCGCCG 2520 GTTGTGGTTT TCTTCTATTT CTTTGTTCCC TCTATCATGT CTTTCCACCA CCAGCACCAC 2580

CACCCCCCCA CTTTCCTCCT TCGGTGCACA AGACACACAC ACAGGCCCAC CACCATCCCC 2640

CGAGAGATGA CACGACAGGT AGGGAACGTT CCATAAAAAA CACGTTTATT TTCCGGAGTT 2700

AGCAAAACCG ATAGAAAAGC GACGAGGTCC GTCGTTTGGG GCTCCCCGAA AGCCACCAAT 2760 ACACCAGAGC CGAACGCAGG TCCTTGGATT TCCAGCAGCT TCCCATGACG CCGGCCGGGT 2820

TATAGGCCAC ACAGTCCGTG CGGGGGACGG GCCCGGGCAA CTGCAACGCA AAGCTCTGCG 2880

GGGTGGCGCA AAACAGGGCC GAAAGGACGG GGGGCGGATT GTTGGCCAGC AGGTAGTGGG 2940

CCATGTACCA GTGGGGCAGG ACTAGCTCGT CGTCGAAGGG CTTCACGCCC GCCATGCACA 3000

TTAGCGTGTT CAGGATCCAG TGGCAGCTGC GGAGGAGAAG GCAGCGGACG CGCTCGAAGG 3060 GAGACGCGTG GCGGGCCACA ACCCCCAACC ACGCCGACAC CTTGACAAAC AGCGAGGGCG 3120

TGGCGTGGCT CCGGGGACAG TTCTCCAGGT ACATCAGCAG GCAGACGAGC TCGAAGTCCC 3180

GGAGGTCCGT GGGGCGAAAC AAGGAGAGCC GGTGCAGCAG AACGAGGGGG GGCACGGCCA 3240

GGCTGTGCAC GTGGTCCTCG TTGGCCGTGA GGACGACGAC CGCAAAACCG CGATACGTCG 3300

GCTGGTCCCC GCAGCGCTTA AAGTAATCCT CCGACGCCAC GTACGCGTCG TCGGAACTCC 3360 CGTCCAGAAC GAACCGCAAC CGCCCCCTGG GGGTGACGTC AACGCGCAGG ACGCTGGTCG 3420

CGGTAAACCG CGGCTGGCGA TCGCTGACCT GGCGCACCTC GCAGGCCATG CGCAGCAGCG 3480

CCTGGTTGCT GATCCCCTCC GCCACCTCGA CCAGACTGCG GTCCCCGGCG ATGGCCTGTT 3540

TGAGGATGGC GGCGGCCGTT CCCTCATCGG CGGGCGTGGG GTCGGCCATC CCTGCGTTGG 3600

ACGCCCCAGC CCTGGTCCGG CGCACCCCTC GGCGTTCTCC CGGGCGACCG GGATCGGGTC 3660 CGGGTCCGGG ACCGGGACCC GCCCCGCGGG GACGCGCTCG CCCGGAAATC GGCGGGGGTT 3720

GGGGAGGGGG GCCGGGGCAG AGCCGCGTGC TGTACGTCCG CCACGAACAG GGCCGCGACG 3780

TCTGTCAGGT ACGTCTGCAG GCGGGTTTTT TTAAAGACCG CCTCCCATAA CTCCTCCTCC 3840

CCTAGGATGA CATCGGAGCC GGTGATGAGC GCGCCCGCTC GGGGGGCGCG AAGCACGTAC 3900

TCGAAATACG GGGCCACGAA GGAGGCGATC GCCCCGCTAG AGTACGAGAT CGACGTTTCC 3960 TGGCCCTGGT TGTTGCGGTG GCGCAGAATC TTGAAGCAGC GCACCAGCTC GTGCTCCCAG 4020

AGGCGCGACA GGCGCTCGAG GTCCTGGCCG TACGCGGGGA TGTACTGGTG CTGGAAACTG 4080

TTGGCCACGT ACGTGTCGTC GTCCATGGAC TTGCTGACGT CGATAATGTC GTAGTCGGCC 4140

CGGAGAAGAT CCGCCTCCGC CGGGCGGCCC GCGCCTCCCC CGGCCGCCCG GTCCGCCGCG 4200

CGATGCTCCC GCTCCAGCGC CCCCGCCTGG GCGCGCCGCA GCTCGCGGTC GCGCGCCTGC 4260 AGCTGGGTCG CCGGGGACAT CTAGAGTCG 4290

(2) INFORMATION FOR SEQ ID NO: 81:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 373 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 81: Val Phe Val Pro Leu Arg Leu Gly Trp Asp Pro Gin Thr Gly Leu Val

1 5 10 15

Val Arg Val Glu Arg Ala Ser Trp Gly Pro Pro Ala Ala Pro Arg Ala 20 25 30 Ala Leu Leu Asp Val Glu Ala Lys Val Asn Phe Asn Pro Leu Ala Ala 35 40 45

Arg Val Ala Glu His Pro Gly Ala Arg Leu Ala Trp Ala Arg Leu Ala

50 55 60

Ala Ile Arg Asn Ser Pro Gin Cys Ala Ser Ser Ala Ser Leu Ala Val 65 70 75 80

Thr Ile Thr Thr Arg Thr Ala Arg Phe Ala Arg Glu Tyr Thr Thr Leu

85 90 95

Ala Phe Pro Pro Thr Ser Lys Glu Gly Ala Phe Ala Asp Leu Val Glu 100 105 110 Val Cys Glu Val Cys Leu Arg Pro Arg Gly His Pro His Arg Val Thr 115 120 125

Ala Arg Val Leu Leu Pro Arg Gly Tyr Asn Tyr Phe Val Ser Ala Gly

130 135 140

Asp Gly Phe Ser Ala Pro Ala Leu Val Phe Arg Gin Trp His Thr Thr 145 150 155 160

Val His Pro Ala Pro Gly Ala Pro Val Phe Ala Phe Leu Gly Pro Gly

165 170 175

Phe Glu Val Arg Gly Gly Pro Leu Gin Tyr Phe Ala Val Leu Gly Phe 180 185 190 Pro Gly Trp Pro Pro Phe Thr Val Pro Ala Ala Ala Ala Ala Glu Ser 195 200 205

Val Arg Asp Leu Leu Arg Gly Ala Ala Cys Thr His Pro Leu Cys Pro

210 215 220

Gly Gly Pro Gly Pro Arg Trp Ala Pro Arg Ser Ser Cys Pro Arg Gly 225 230 235 240

His Gly Arg Pro Trp Pro Arg Arg Arg Pro Ala Ala Ser Cys Pro Pro

245 250 255

Phe Gly Lys Arg Trp Arg Gly Gly Thr Pro Arg Pro Pro Pro Ser Asn 260 265 270 Tyr Ser Thr Pro Arg Arg Pro Ser Gly Arg Ser Gly Arg Arg Gly Phe 275 280 285

Val Ser Pro Gly Ser Arg Pro Ser Ser Trp Pro Pro Ser Arg Ala Ser

290 295 300

Gly Arg Pro Gly Cys Arg Lys Pro Gly Gly Gly Arg Ala Trp Lys Gly 305 310 315 320

Trp Thr Arg Trp Trp Arg Pro Pro Pro Arg Ser Pro Gly Pro Gly Pro

325 330 335

Cys Trp Ser Ala Trp Cys Arg Thr Arg Ala Thr Pro Ala Pro Arg Ser 340 345 350

Gly Ser Cys Ser Ala Gly Ser Trp Pro Pro Ser Ala Cys Arg Ser Ser

355 360 365

Arg Arg Pro Ala Arg 370

(2) INFORMATION FOR SEQ ID NO: 82:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 380 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 82:

Val Ala Ser Glu Ala Ala Gly Arg Leu Leu Pro Ala Phe Arg Glu Ala 1 5 10 15

Val Ala Arg Trp His Pro Thr Ala Thr Thr Ile Gin Leu Leu Asp Pro

20 25 30

Pro Ala Ala Val Gly Pro Val Trp Thr Ala Arg Phe Cys Phe Ser Gly 35 40 45 Leu Gin Ala Gin Leu Leu Ala Ala Gly Leu Gly Glu Ala Gly Leu Pro 50 55 60

Glu Arg Arg Ala Gly Leu Glu Arg Leu Asp Ala Leu Val Ala Ala Ala 65 70 75 80

Pro Ser Glu Pro Trp Ala Arg Ala Val Leu Glu Arg Leu Val Pro Asp 85 90 95

Ala Cys Asp Ala Cys Pro Ala Leu Arg Gin Leu Leu Gly Gly Val Met

100 105 110

Ala Ala Val Cys Leu Gin Ile Glu Gin Thr Ala Ser Ser Val Lys Phe 115 120 125 Ala Val Cys Gly Gly Thr Gly Ala Ala Phe Trp Gly Leu Phe Asn Val 130 135 140

Asp Pro Gly Asp Ala Asp Ala Ala His Gly Ala Ile His Asp Ala Arg 145 150 155 160

Arg Ala Leu Glu Ala Ser Val Arg Ala Val Leu Ser Ala Asn Gly Ile 165 170 175

Arg Pro Arg Leu Ala Pro Ser Leu Ala Leu Glu Gly Val Tyr Thr His

180 185 190

Val Val Thr Trp Ser Gin Thr Gly Ala Trp Phe Trp Asn Ser Arg Asp 195 200 205

Asp Thr Asp Phe Leu Gin Gly Phe Pro Leu Arg Gly Pro Ala Tyr Ala

210 215 _ 220

Ala Ala Ala Glu Val Met Arg Asp Ala Leu Arg Arg Ile Leu Arg Arg 225 230 235 240

Pro Ala Ala Gly Pro Pro Glu Glu Ala Val Cys Ala Arg Ile Met Glu

245 250 255

Asp Ala Cys Asp Arg Phe Val Leu Asp Ala Phe Gly Arg Arg Leu Asp 260 265 270 Ala Glu Tyr Trp Ser Val Leu Thr Pro Pro Gly Glu Ala Asp Asp Pro 275 280 285

Leu Pro Gin Thr Ala Phe Arg Gly Gly Ala Leu Leu Asp Ala Glu Gin

290 295 300

Tyr Trp Arg Arg Val Val Arg Val Cys Pro Gly Gly Gly Glu Ser Val 305 310 315 320

Gly Val Pro Val Asp Leu Tyr Pro Arg Pro Leu Val Leu Pro Pro Val

325 330 335

Asp Cys Ala His His Leu Arg Glu Ile Leu Arg Glu Ile Gin Leu Val 340 345 350 Phe Thr Gly Val Leu Glu Gly Val Trp Gly Glu Gly Gly Ser Phe Val 355 360 365

Tyr Pro Phe Glu Glu Lys Met Arg Phe Leu Phe Pro 370 375 380

(2) INFORMATION FOR SEQ ID NO: 83:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 302 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 83:

Val Arg Arg Thr Arg Ala Gly Asn Ala Gly Met Ala Asp Pro Thr Pro

1 5 10 15

Ala Asp Glu Gly Thr Ala Ala Ala Ile Leu Lys Gin Ala Ile Ala Gly 20 25 30

Asp Arg Ser Leu Val Glu Val Ala Glu Gly Ile Ser Asn Gin Ala Leu

35 40 45

Leu Arg Met Ala Cys Glu Val Arg Gin Val Ser Asp Arg Gin Pro Arg 50 55 60

Phe Thr Ala Thr Ser Val Leu Arg Val Asp Val Thr Pro Arg Gly Arg 65 70 . 75 80

Leu Arg Phe Val Leu Asp Gly Ser Ser Asp Asp Ala Tyr Val Ala Ser 85 90 95

Glu Asp Tyr Phe Lys Arg Cys Gly Asp Gin Pro Tyr Gly Phe Ala Val

100 105 110

Val Val Leu Thr Ala Asn Glu Asp His Val His Ser Leu Ala Val Pro 115 120 125 Pro Leu Val Leu Leu His Arg Leu Ser Leu Phe Arg Pro Thr Asp Leu 130 135 140

Arg Asp Phe Glu Leu Val Cys Leu Leu Met Tyr Leu Glu Asn Cys Pro 145 150 155 160

Arg Ser His Ala Thr Pro Ser Leu Phe Val Lys Val Ser Ala Trp Leu 165 170 175

Gly Val Val Ala Arg His Asp Phe Glu Arg Val Arg Cys Leu Leu Leu

180 185 190

Arg Ser Cys His Trp Ile Leu Asn Thr Leu Met Cys Met Ala Gly Val 195 200 205 Lys Pro Phe Asp Asp Glu Leu Val Leu Pro His Trp Tyr Met Ala His 210 215 220

Tyr Leu Leu Ala Asn Asn Pro Pro Pro Val Leu Ser Ala Leu Phe Cys 225 230 235 240

Ala Thr Pro Gin Ser Phe Ala Leu Gin Leu Pro Gly Pro Val Pro Arg 245 250 255

Thr Asp Cys Val Ala Tyr Asn Pro Ala Gly Val Met Gly Ser Cys Trp

260 265 270

Lys Ser Lys Asp Leu Arg Ser Ala Leu Val Tyr Trp Trp Leu Ser Gly 275 280 285 Ser Pro Lys Arg Arg Thr Ser Ser Leu Phe Tyr Arg Phe Cys 290 295 300

(2) INFORMATION FOR SEQ ID NO: 84:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 236 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 84: Met Ser Pro Ala Thr Gin Leu Gin Ala Arg Asp Arg Glu Leu Arg Arg

1 5 . 10 15

Ala Gin Ala Gly Ala Leu Glu Arg Glu His Arg Ala Ala Asp Arg Ala 20 25 30

Ala Gly Gly Gly Ala Gly Arg Pro Ala Glu Ala Asp Leu Leu Arg Ala

35 40 45

Asp Tyr Asp Ile Ile Asp Val Ser Lys Ser Met Asp Asp Asp Thr Tyr 50 55 60 Val Ala Asn Ser Phe Gin His Gin Tyr Ile Pro Ala Tyr Gly Gin Asp 65 70 75 80

Leu Glu Arg Leu Ser Arg Leu Trp Glu His Glu Leu Val Arg Cys Phe

85 90 95

Lys Ile Leu Arg His Arg Asn Asn Gin Gly Gin Glu Thr Ser Ile Ser 100 105 110

Tyr Ser Ser Gly Ala Ile Ala Ser Phe Val Ala Pro Tyr Phe Glu Tyr

115 120 125

Val Leu Arg Ala Pro Arg Ala Gly Ala Leu Ile Thr Gly Ser Asp Val

130 135 140 Ile Leu Gly Glu Glu Glu Leu Trp Glu Ala Val Phe Lys Lys Thr Arg

145 150 155 160

Leu Gin Thr Tyr Leu Thr Asp Val Ala Ala Leu Phe Val Ala Asp Val

165 170 175

Gin His Ala Ala Leu Pro Arg Pro Pro Ser Pro Thr Pro Ala Asp Phe 180 185 190

Arg Ala Ser Asp Arg Gly Gly Ser Arg Ser Arg Thr Arg Thr Arg Ser

195 200 205

Arg Ser Pro Gly Arg Thr Pro Arg Gly Ala Pro Asp Gin Gly Trp Gly 210 215 220 Val Gin Arg Arg Asp Gly Arg Pro His Ala Arg Arg 225 230 235

(2) INFORMATION FOR SEQ ID NO: 85:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3664 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 85: GTGTGTTTTT GTTTGTCTCC ACTTGAAGAG GCGTAAATTT GAGTTTCTAG GGGGGGGCCA 60

GAGGAAAACC ANCAAGGCCC TTTAGGTTTT CGCCCTTNGN GGCCCNTGGT AACGTTTTAT 120

CCGGNGTTAT CCAGATAGGG GAGACCCANA CCCCCTTGAG GAGGNAAACC TTTCCCCACC 180

CGNACCCGCG CCCCAGATTT AGTGAGGGGG ANGGAAGAGC CCCAAACACC NACCCCCTTT 240 CCGGNGGGTN GCGATTTAAT ATGCANTGCA GACAGTTCTC GATTGGAACG GGCATGGCGC 300

AACCANTNAT GGGTNGTCAT CTTGCACCCC GCTACATTAA GTTCGTTTGA AGTGGGGATG 360

GGGGTAACAT TAACAGAACA GTTAGCCAGA TACGCCAGGG GCATTACCTC ATAAAGGACA 420

AAGTGAGTTC CACGCGTGCG CCGTTTTAGA TTAGTGATCC CCCGGCTGCA GGATTCGATN 480

GGGAGACAGT CACGAGTCNN GGACCACGTC GGNGACCCAG GCCCCAGNNT GTGTCCNCCC 540 AGCCCCCCAG TCATGACGTT TGTGAGCACG ACGAGTCTGC GGCCGGGCTG GGGGCGCGTC 600

TTCGTTCGCG TGGGCCATCA CTTCCTGAAT GGCTGCGGTG CGCTGATCGC CCGAGCTGGC 660

GAAGGGCGCC ACAACCAGCG CGCGCTCCGT CTGCAGGCCC TTCCACGTGT CGTGGAGTTC 720

CTGAACGAAC TCGGCCACCC GCTCGGGGCC CGTGGCCGCG CGCGCGGCCT GATAGCCGGC 780

CGAGAGGCGC CGCCAGCGCG CCAGGAACTG ACTCATGTAA CAGAACCCGG GGACCTGGTC 840 CCCCGACATC AACTTTGACG CCCTGGCGTG GATGCCCGAC ACGATGGCCA GGAACCCGTG 900

GATTTCCCGC CGCACGACGG CCAGCACGTT ACCCTCGTGC GAGACCTGGG CCGCCAGCTC 960

GTCGCATACC CCGAGGTGCG CCGTCGTCTC GGTGACGACG GACCGCAGCC CCGCGAGGGA 1020

CGCGACCAGC GCGCGCTTGG CGTCGTGATA CATGCCGCAG TACTGGCTCA CCGCGTCGCC 1080

CATGGCCTCG GGGCGCCAGG GCCCCAGGCG CTCGTGGGCG TCTGCGACCA CGGCGTACAG 1140 GCGGTGCCCG TCGCTCTCGA ACCGGCACTC AAAGAAGGCG GCGAGCGTGC GCATGTGCAG 1200

CCGCAGCAGC ACGATCGCGT CCTCCAGCTG GCGGACCAGG GGGTCGGCGC GCTCGGCAAA 1260

CTCCTGCATC ACCCCCCGGG CCGCCAGGGC GTACATGCTG ATCAGCAGCA GGCTGCTGCC 1320

CACCTCGGGA GGCTGGGGGG GAGGCAGCTG GACCGCGGGC CGCAGCTGCT CGACGGCCCC 1380

CCTGGCGATC ACGTACAGCT CGCGCAGCAG CTGCTCGATG TTGTCGGCCA TCTGCATCGT 1440 GGGCCCGACG CCGGCCCGGG TGGCCGGTTC GAGGAGGGTG ATCAGCGCGC CCAATTTTGT 1500

GCGGTGCCCC TCGACGGTGG GGAGATAGCC CAGGCCGAAG TCGCGCGCCC AGGCCAGCAC 1560

CCGCAGGGCA AACTCGATGG GGCGGGGCAG GTAGGCAGCG TTGCACGTGG CCCTCAGCGC 1620

GTCCCCGACC ACCAGGGCCA GCACGTAAGG GACGAACCCC GGGTCGGCGA GGACGTTGGG 1680

GTGGATGCCC TCCAGGGCCG GGAAGCGGAT CTTGGTGGCC GCGGCCAGGT GAACCGAGGG 1740 GGCGTGGCTA GGCGGCCCGA CGGGGAGCAG CGCGGACAGC GGCGTGGCCG GGGTGGTGGG 1800

GGTCAGGTCC CAGTGGGTCT GGCCGTACAC GTCGAGCCAG ATGAGCGCCG TCTCGCGCAG 1860

GAGGCTGGGC TGGCCGGCGC TGAAGCGGCG CTCGGCCGTC TCAAACTCCC CCACGAGCGT 1920

GCGCCGCAGG CTCGCCAGGT GTTCCGTCGG CACGGCCGGG CCCATGATGC GCGCCAGCGT 1980

CTGGCTGAGG ACGCCGCCCG ACAGGCCGAC CGCCTCACAG AGCCGCCCGT GCGTGTGCTC 2040 GCTGGCGCCC TGGATCCGCC GGAACGTTTT CACGTAGCCG GCGTAGTGCC CGTACTCCCG 2100

CGCGAGCCCG AACACGTTCG CCCCCGCAAG GGCAATGCAC CCAAAGAGCT GCTGGATCTC 2160

GCTGAGCCCG TGGCCGGGGG GCGTCCGCGC GGGCACCCCC GCCACCAAAA ACCCCTCCAG 2220

GGCCGATATG TACTGGGTGC AGTGCGCGGG CGTGAACCCC GCGTCGGTAA GCGTGTTGAT 2280

CACCACGGAG GGCGAGTTGC TGTTTTGGAC CAAAGCCCAC GTCTGCTGCA GCAGCGCGAG 2340 GAGCCGTTGC TGGGCCCCGG CGGAGGGCGG CTCCCCTAGC TGCAGCAGGC CGGTGACGGC 2400

CGGACGGAAG ATGGCCAGCG CCGACGCACT CAGAAACGGC ACGTCGGGGT CGAAGACGGC 2460

CGCGTCCGTC CGCACGCGCG CCATCAGCGT CCCCGGGGGC GCGCACGCCG ACCGCGGGCT 2520

GACGCGGCTT AGGGCGGTCG ACACGCGCAC CTCCTCGCGA CTGCGAACCA TTTTGGTGGC 2580 CTCGAGGGGC GGGATCATGA TAGCCGGGTC GATCTCCCGC ACCGTGTGCT GAAACTGGGC 2640

CAGCAGCGGC GGCGGGACCA CCGCGCCCCG ATCGGGGGTC GTCAGGTACT CGTCCACCAG 2700

CGCCAGCGTA AACAGGGCCC GCGTGAGGGG GGTCAGGGCG GCGTCGTCGA TGCGCTGTAG 2760

GTGCGCCGAG AACAGCGTCA CCCAATTGCT GACCAGGGCC AAGAACCGGA GACCCTCTTG 2820 CACGATCGGG GACGGGAAGA GCAGGCTGTA CGCCGGGGTG GTCAGGTTGG CGCCGGGTTG 2880

CCCCAGGGGA ACCGGGGACA TCTTAAGCGA CATCTCCCCG AGGGCCTCCA GGGAGGTCCG 2940

CGGGTTCATG GCCAGGCAGC TCTGGGTGAC GGTCCGCCAG CGGTCGATCC ACTCCACGGC 3000

ACACTGGCGG ACGCGCACCG GCCCCAGGGC CGCCGTGGTG CGCAGCCCGG CGGCCTCCAG 3060

CGCGTGGGTC GTGTCGGAGC CGGTGATCGC CAGGACCGTG TCCTTGATGA CGTCCATCTC 3120 CCGGAAGGCC GCCTCGGGGG TCTCGGGGAG CGCCACCGCC ATGCGGTGCA CCAGCAGCCC 3180

GGGGAGGTTC TCGGCCAAGA GCGCCGTCTC CGGAAGCCCG TGGGCCCGGT GCAAGGCGCA 3240

CAGTTGCTCC AGGAGCGGGT GCCAGCACGC CCGCGCCTCC GCCGGGCCGA CCGCCGCGCC 3300

CGACAACAGA AACGCCGCCG TGGCGGCGCG CAGTTTGGCC GCGGACAGAA ACGCCGGCTC 3360

GTCCGCGCTG CCCGCCGGCT CGCTCGAGGG GGAGGGCGGC CGGCGGAGGT TGGTCAGGCT 3420 CCCCAACAGG ACCTGCAACG GTCCGTTTGG GGGTGGAGCG GACGGGGGGG TCATGCCGGC 3480

GGGCGCCGGG ACCTGGAGCG CGCTGTCCGA CATGGCGACC GGCGTGCGCG CTCGGCGACG 3540

CGGCGCGGAG ACCGCGGGCC CAAACGGGAA TGACTGCCGC CGCCCTATAC GGAGGGGGTA 3600

AGTATCGCCC GGGGACCCTT CGAAACCCCG GGCGTGTCGC AAGTACGCCC GCGAAAGGCG 3660

CGG 3664

(2) INFORMATION FOR SEQ ID NO: 86:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1043 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 86:

Pro Arg Leu Ser Arg Ala Tyr Leu Arg His Arg Phe Glu Gly Ser Pro 1 5 10 15 Gly Asp Thr Tyr Pro Leu Arg Ile Gly Arg Arg Gin Ser Phe Pro Phe 20 25 30

Gly Pro Ala Val Ser Ala Pro Arg Arg Arg Ala Arg Thr Pro Val Ala

35 40 45

Met Ser Asp Ser Ala Leu Gin Val Pro Ala Pro Ala Gly Met Thr Pro 50 55 60

Pro Ser Ala Pro Pro Pro Asn Gly Pro Leu Gin Val Leu Leu Gly Ser 65 70 75 80

Leu Thr Asn Leu Arg Arg Pro Pro Ser Pro Ser Ser Glu Pro Ala Gly 85 90 95

Ser Ala Asp Glu Pro Ala Phe Leu Ser Ala Ala Lys Leu Arg Ala Ala

100 . 105 110

Thr Ala Ala Phe Leu Leu Ser Gly Ala Ala Val Gly Pro Ala Glu Ala 115 120 125

Arg Ala Cys Trp His Pro Leu Leu Glu Gin Leu Cys Ala Leu His Arg

130 135 140

Ala His Gly Leu Pro Glu Thr Ala Leu Leu Ala Glu Asn Leu Pro Gly 145 150 155 160 Leu Leu Val His Arg Met Ala Val Pro Glu Thr Pro Glu Ala Ala Phe

165 170 175

Arg Glu Met Asp Val Ile Lys Asp Thr Val Leu Ala Ile Thr Gly Ser

180 185 190

Asp Thr Thr His Ala Leu Glu Ala Ala Gly Leu Arg Thr Thr Ala Ala 195 200 205

Leu Gly Pro Val Arg Val Arg Gin Cys Ala Val Glu Trp Ile Asp Arg

210 215 220

Trp Arg Thr Val Thr Gin Ser Cys Leu Ala Met Asn Pro Arg Thr Ser 225 230 235 240 Leu Glu Ala Leu Gly Glu Met Ser Leu Lys Met Ser Pro Val Pro Leu

245 250 255

Gly Gin Pro Gly Ala Asn Leu Thr Thr Pro Ala Tyr Ser Leu Leu Phe

260 265 270

Pro Ser Pro Ile Val Gin Glu Gly Leu Arg Phe Leu Ala Leu Val Ser 275 280 285

Asn Trp Val Thr Leu Phe Ser Ala His Leu Gin Arg Ile Asp Asp Ala

290 295 300

Ala Leu Thr Pro Leu Thr Arg Ala Leu Phe Thr Leu Ala Leu Val Asp 305 310 315 320 Glu Tyr Leu Thr Thr Pro Asp Arg Gly Ala Val Val Pro Pro Pro Leu

325 330 335

Leu Ala Gin Phe Gin His Thr Val Arg Glu Ile Asp Pro Ala Ile Met

340 345 350

Ile Pro Pro Leu Glu Ala Thr Lys Met Val Arg Ser Arg Glu Glu Val 355 360 365

Arg Val Ser Thr Ala Leu Ser Arg Val Ser Pro Arg Ser Ala Cys Ala

370 375 380

Pro Pro Gly Thr Leu Met Ala Arg Val Arg Thr Asp Ala Ala Val Phe 385 390 395 400 Asp Pro Asp Val Pro Phe Leu Ser Ala Ser Ala Ile Phe Arg Pro Ala

405 410 415

Val Thr Gly Leu Leu Gin Leu Gly Glu Pro Pro Ser Ala Gly Ala Gin 420 425 430 Gin Arg Leu Leu Ala Leu Leu Gin Gin Thr Trp Ala Leu Val Gin Asn

435 440 445

Ser Asn Ser Pro Ser Val Val lie Asn Thr Leu Thr Asp Ala Gly Phe

450 455 460 Thr Pro Ala His Cys Thr Gin Tyr Ile Ser Ala Leu Glu Gly Phe Leu

465 470 475 480

Val Ala Gly Val Pro Ala Arg Thr Pro Pro Gly His Gly Leu Ser Glu

485 490 495

Ile Gin Gin Leu Phe Gly Cys Ile Ala Gly Ala Asn Val Phe Gly Leu 500 505 510

Ala Arg Glu Tyr Gly His Tyr Ala Gly Tyr Val Lys Thr Phe Arg Arg

515 520 525

Ile Gin Gly Ala Ser Glu His Thr His Gly Arg Leu Cys Glu Ala Val

530 535 540 Gly Leu Ser Gly Gly Val Leu Ser Gin Thr Leu Ala Arg lie Met Gly

545 550 555 560

Pro Ala Val Pro Thr Glu His Leu Ala Ser Leu Arg Arg Thr Leu Val

565 570 575

Gly Glu Phe Glu Thr Ala Glu Arg Arg Phe Ser Ala Gly Gin Pro Ser 580 585 590

Leu Leu Arg Glu Thr Ala Leu Ile Trp Leu Asp Val Tyr Gly Gin Thr

595 600 605

His Trp Asp Leu Thr Pro Thr Thr Pro Ala Thr Pro Leu Ser Ala Leu

610 615 620 Leu Pro Val Gly Pro Pro Ser His Ala Pro Ser Val His Leu Ala Ala

625 630 635 640

Ala Thr Lys Ile Arg Phe Pro Ala Leu Glu Gly Ile His Pro Asn Val

645 650 655

Leu Ala Asp Pro Gly Phe Val Pro Tyr Val Leu Ala Leu Val Val Gly 660 665 670

Asp Ala Leu Arg Ala Thr Cys Asn Ala Ala Tyr Leu Pro Arg Pro Ile

675 680 685

Glu Phe Ala Leu Arg Val Leu Ala Trp Ala Arg Asp Phe Gly Leu Gly

690 695 700 Tyr Leu Pro Thr Val Glu Gly His Arg Thr Lys Leu Gly Ala Leu Ile

705 710 715 720

Thr Leu Leu Glu Pro Ala Thr Arg Ala Gly Val Gly Pro Thr Met Gin

725 730 735

Met Ala Asp Asn Ile Glu Gin Leu Leu Arg Glu Leu Tyr Val Ile Arg 740 745 750

Ala Val Glu Gin Leu Arg Pro Ala Val Gin Leu Pro Pro Pro Gin Pro

755 760 765

Pro Glu Val Gly Ser Ser Leu Leu Leu Ile Ser Met Tyr Ala Arg Val 770 775 780

Met Gin Glu Phe Ala Glu Arg Ala Asp Pro Leu Val Arg Gin Leu Glu 785 790 795 800

Asp Ala Ile Val Leu Leu Arg Leu His Met Arg Thr Leu Ala Ala Phe 805 810 815

Phe Glu Cys Arg Phe Glu Ser Asp Gly His Arg Leu Tyr Ala Val Val

820 825 830

Ala Asp Ala His Glu Arg Leu Gly Pro Trp Arg Pro Glu Ala Met Gly 835 840 845 Asp Ala Val Ser Gin Tyr Cys Gly Met Tyr His Asp Ala Lys Arg Ala 850 855 860

Leu Val Ala Ser Leu Ala Gly Leu Arg Ser Val Val Thr Glu Thr Thr 865 870 875 880

Ala His Leu Gly Val Cys Asp Glu Leu Ala Ala Gin Val Ser His Glu 885 890 895

Gly Asn Val Leu Ala Val Val Arg Arg Glu Ile His Gly Phe Leu Ala

900 905 910

Ile Val Ser Gly Ile His Ala Arg Ala Ser Lys Leu Met Ser Gly Asp 915 920 925 Gin Val Pro Gly Phe Cys Tyr Met Ser Gin Phe Leu Ala Arg Trp Arg 930 935 940

Arg Leu Ser Ala Gly Tyr Gin Ala Ala Arg Ala Ala Thr Gly Pro Glu 945 950 955 960

Arg Val Ala Glu Phe Val Gin Glu Leu His Asp Thr Trp Lys Gly Leu 965 970 975

Gin Thr Glu Arg Ala Leu Val Val Ala Pro Phe Ala Ser Ser Gly Asp

980 985 990

Gin Arg Thr Ala Ala Ile Gin Glu Val Met Ala His Ala Asn Glu Asp 995 1000 1005 Ala Pro Pro Ala Arg Pro Gin Thr Arg Arg Ala His Lys Arg His Asp 1010 1015 1020

Trp Gly Ala Gly Xaa Thr Xaa Xaa Gly Ala Trp Val Xaa Asp Val Val 1025 1030 1035 104

Xaa Asp Ser

(2) INFORMATION FOR SEQ ID NO: 87:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5033 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 87:

CGCGGTCGAC TCTAGAGGAT CCCCTGCGCC GCGTCGGGAT TCACCAACTC GTTCGCGCGC 60

TGCAGGAGGT TCTTGCCCTC GCAGACCGTC ACGCGAATGG TGGTGAGGTC GAGGAGCTCG 120

TTGAGGTCTC CGTCGGTGTG CGGCCGCGAC ATGTCCCACA GCTGTACCGC CGCCAGCCGG 180

GCGTGCGTGG CCGCCAGGCG CCCGACCGCG GCGCAAAAAA CGCGCTTGTT GAACCCGGCC 240

ACCCGGGGGG TCCACGGCGC CGTGGGGCTC GGTGGGGCGG TGCTGAATTG CACCTCCTTG 300 GCCAGTCCCT GGGCGGGTGT CTTGGTTCTT CCCGAGGCCG TGGGAGCGGG GGCGTCTAGG 360

AGCACGGCGG TATCGGCCTG GGCGGGTCGC CTGCCGCGGG CAGGGTCGGT CGCCGGGGTC 420

GCGGGGGCCT TAGGGCGCCC CGCGCGTCAT TTTGGGGGTC CGCGCGGGAG GGGCGTGCGA 480

GCGCCCGCCG GCGCCCACGG GGCCCCCGGG GGGTGGAGGA GCGCGCGCGG GGCCGGGGCC 540

GTGAGAGCCC GCGACGGACG CCGAACGACG CGGTCGCGCG GTATCCCGGG ACTCGTCGTT 600 GTCTTCGGAC GACGACGAGT CCCGGTAGAG GGCATACCCA GCCTCGTCAT AATGGAGAAA 660

GCGAACCTCG CCCCTTGGGC GCGCGCGCAT CGGGCCAGCG CCGCGGCGGA AGTCGTCGCG 720

CGGACTCTCT GGATCCGCCG GGGAGACCGG GCCATAGTAC AGCTCCTCGT GGGTCCCGCG 780

CGGCGCTTCC CGCGGACACG ACTTGACGGA GCGGCGAGAG GTCATGGTCT ATCGGAGACA 840

CCGGGGACGC CCGTGCGGAT CACAGGGAAG GCGTCGGCGA AGCAGGCAGA GAGCGTCGGA 900 AGGCGGCGAG GGAGGGAAAG AGGGAGACCG GCGGGGTACG GGAGAGCAGC GAGGGCCTGC 960

GTAACCCACG GGGGCCGCGG GAGTGGCTCC CTGCGGGTTG CGGGGGAGAG TTTATAGGAA 1020

GTGGATATAA CCGCAGGCGA CGGGACTAAC CAATCCCCGG GGGGGCAACG GACAGACACG 1080

CCCCGAACCG GCCCGACTTC CGCGAGGAAG CAAAGGCCGG GGGCCGCCCA ACGACACGCC 1140

CACCCCTTCC CAACAGGGCG GGCTCAGGCT GACCCGGCGG CCAGTGCCCG CTGGCATATC 1200 TGATACACGT GCGCGATCAT ACATACGCCC ATCGAGGTCA TGCCTAGATA AAAGGGCACC 1260

AGGACCCCCG GGACGGACAC CACACCGGCG CTGTCGCCCC GGCATTGCGC GTCCCCGATA 1320

ACGCCGCGTG CGCCTGCCGC GTTCGGCGGC TCCCCGGGCA CGCCCGCGAC GAGCGCGACG 1380

AACAACAGCA CCACCCAGCG GCCCAGTCTT GCGGGTTTCC CCGTCATCGC GGCGATGAGT 1440

CAGTGGGGGC CCAGGGCGAT CCTTGTCCAG ACGGACAGCA CCAACCGGAA TGCCGATGGG 1500 GACTGGCAAG CGGCCGTAGC TATTCGCGGG GGCGGAGTCG TTCAACTGAA CATGGTCAAC 1560

AAACGCGCCG TGGATTTTAC CCCGGCAGAA TGCGGGGACT CCGAATGGGC CGTGGGCCGC 1620

GTCTCTCTGG GCCTGCGAAT GGCAATGCCG CGTGACTTCT GCGCGATTAT TCACGCCCCC 1680

GCGGTATCCG GCCCCGGGCC CCACGTGATG CTCGGTCTCG TCCACTCGGG CTACCGCGGA 1740

ACCGTCCTGG CCGTGGTCGT ATCCCCGAAC GGGACGCGCG GGTTTGCCCC CGGGGCCCTC 1800 CGGGTCGACG TGACGTTTCT GGACATCCGG GCCACCCCCC CGACCCTCAC CGAGCCGAGC 1860

TCCCTGCACC GGTTTCCGCA GTTGGCGCCG TCCCCGCTGG CAGGGTTACG AGAAGATCCT 1920

TGGTTGGACG GGGCGCTCGC GACCGCCGGG GGGGCGGTGG CCCTGCCGGC CAGACGGCGC 1980

GGGGGATCGC TGGTCTACGC GGGCGAGCTA ACGCAGGTGA CCACCGAGCA CGGCGACTGC 2040

GTGCACGAGG CGCCCGCCTT TCTGCCAAAG CGCGAGGAGG ACGCAGGCTT TGACATTCTC 2100 ATCCACCGAG CCGTGACCGT CCCGGCCAAC GGCGCCACGG TCATACAGCC GTCCCTCCGC 2160

GTATTGCGCG CGGCCGACGG ACCAGAGGCC TGCTATGTGC TGGGGCGGTC GTCGCTCAAT 2220

GCCAGGGGCC TCCTGGTCAT GCCTACGCGC TGGCCCTCCG GGCACGCCTG TGCGTTTGTT 2280

GTATGTAACC TGACCGGAGT CCCGGTGACC CTACAAGCCG GGTCCAAGGT CGCCCAGCTG 2340 CTCGTCGCGG GGACCCACGC CCTCCCCTGG ATCCCCCCCG ACAACATCCA CGAGGACGGC 2400

GCATTCCGGG CCTACCCCAG AGGGGTTCCG GACGCGACCG CCACCCCCCG AGACCCGCCG 2460

ATTTTGGTGT TTACGAACGA GTTTGACGCG GACGCCCCCC CAAGCAAGCG GGGGGCCGGG 2520

GGGTTTGGCT CCACTGGCAT CTAAACCGCG CCTCGCGTCG GGCCAGATGG GGCCCCGGTC 2580 AATAAAGAGC TCTGTTTCGC ATATGCCCTG GTGTTGGCGG TTTTTTTTTT GTTGTCTGTC 2640

TGCCCGGCAC TCGGTTGTCC GTTCTGTCGT CGCTATCACA TACGCACAAA CACACGGGTA 2700

GAGTGGAACC GAAACCGGTC GACGTTTATT CACCACACAG AAACACAAGC TAAGCGAGAA 2760

GGAGGGGGGC CTCGGTCGAC GAGGCCTGGC GTTTGGGGGC GGACGTGCGA TGACGTGGGT 2820

CCGGTGTAGG GTCCGCGGGG GGCACGGGCC CGGGGCGAAC GGGGGATCTG TCGCCGGCGT 2880 GGGTGACTGG GACCGACGCA ACCTCCGGGG CTTGTGCCCT CGTAGGCCCG GGGGGGGCCT 2940

CGGTCGCTCC GAGCCCCGCG GTGCGGGTCC CTCCGGCCAG AGCCGAGGTG GAGAGACCAA 3000

GGGCCCGCTC CGCGATCGCC ACGTCCTCCA TGACCACGTC GCTTTCGGCC ATGCTCCGAA 3060

TGGCCTGGGA GACGAGCACG TCCGCCGACT TGTCCGCGGC CCCCACCGAC ATGTACATCT 3120

GCAGGATGGT GGCCATGCAC GTGTCCGCCA GGCGGCGCAT CTTGTCCCGA TGCGCCGCAA 3180 CGGCCCCGTC GATGGTGGAG CCCTCGAGTC CCGGGTGGTG GCGCGCCAGC CTCTCGAGGT 3240

TGACCATGCA GGCGTGGTAT GTGCGGGCCA GGGCGCGCGC CTTCACGAGG CGCCGGGTGT 3300

CGTCCAGCGA CTCTAGGGCG TCATCAAGCG TGATGGGGGC GGGCAAAAGC GCATTGACCA 3360

CCGCCAGGGC CTCCTGCAGC CGCGGCTCCG CCTCCGAGGG CGGATCCGCG GCCCGAATCA 3420

TCTCATATTG TTGTTCCTCG GGGCGCGTGC CCCAACCGCA CAGCACCCCG AGCAGGGACG 3480 CCATCCCGGA ACACGCGCGC GGCTCTGCGC CGGCTTTCCC CCACCCCACC CCCTCCGGGT 3540

TCGCAGGGGC GATGGGGACG GAAGACTGCG ATCACGAAGG GCGGTCGGTT GCGGCTCCCG 3600

TGGAGGTTAT GGCGCTGTAT GCGACCGACG GGTGCGTTAT CACCTCCTCG CTCGCCCTCC 3660

TCACAAACTG CCTGCTGGGG GCCGAGCCGT TGTATATATT CAGCTACGAC GCGTACCGGC 3720

CCGATGCGCC CAATGGCCCC ACGGGCGCGC CCACCGAACA GGAGAGGTTC GAGGGGAGCC 3780 GGGCGCTCTA CCGGGATGCG GGGGGGCTAA ATGGCGATTC ATTTCGGGTG ACCTTTTGTT 3840

TATTGGGGAC GGAAGTGGGC GTGACCCACC ACCCGAAAGG GCGCACCCGG CCCATGTTTG 3900

TGTGCCGCTT CGAGCGAGCG GACGACGTCG CCGTGCTCCA AGACGCCCTG GGCCGCGGGA 3960

CCCCATTGCT CCCGGCCCAC ATCACAGCAA CTCTGGACTT GGAGGCGACG TTTGCGCTCC 4020

ACGCTAACAT CATCATGGCT CTCACCGTGG CCATAGTCCA CAACGCCCCC GCCCGCATCG 4080 GCAGCGGCAG CACCGCTCCC CTGTATGAGC CCGGCGAATC GATGCGCTCG GTCGTCGGGC 4140

GCATGTCCCT GGGGCAGCGC GGCCTCACCA CGCTGTTCGT GCACCACAAG GCGCGCGTGC 4200

TGGCGGCGTA CCGCCGGGCG TATTATGGGA GCGCCCAAAG CCCCTTTTGG TTTCTGAGCA 4260

AATTCGGCCC GGACAAAAAG AGCCTGGTGC TGGCCGCTAG GTACTACCTA CTCCAGGCTC 4320

CGCGCTTGGG GGGCGCCGGA GCCACGTACG ATCTGCAGGC CGTGAAAGAC ATCTGCGCGA 4380 CCTACGCGAT CCCCCACGAC CCACGCCCCG ACACCCTCAG TGCCGCGTCC TTGACCTCGT 4440

TCGCCGCCAT CACTCGGTTC TGTTGCACGA GCCAGTACTC CCGCGGGGCC GCGGCCGCTG 4500

GGTTTCCGCT GTATGTGGAG CGCCGCATCG CCGCCGACGT ACGCGAGACC GGCGCGCTGG 4560

AGAAGTTCAT CGCCCACGAT CGCAGTTGCC TGCGCGTGTC CGACCGGGAA TTCATTACGT 4620

ACATCTACCT GGCCCACTTT GAGTGCTTCA GCCCCCCGCG CCTGGCCACG CATCTCCGGG 4680 CCGTGACCAC CCACGACCCC AGCCCCGCGG CCAGCACGGA GCAGCCCTCG CCCCTGGGTC 4740

GGGAGGCGGT GGAACAGTTC TTCCGGCACG TGCGCGCCCA GCTGAACATC CGCGAGTACG 4800

TAAAGCAAAA CGTCACCCCC AGGGAAACCG CCCTGGCGGG AGACGCGGCC GCCGCCTACC 4860

TGCGCGCGCG CACGTATGCC CCGGCGGCCC TCACGCCCGC CCCCGCGTAC TGCGGGGTCG 4920 CAGACTCGTC CACCAAAATG ATGGGACGTC TGGCGGAAGC AGAAAGGCTC CTAGTCCCCC 4980 ACGGCTGGCC CGCGTTCGCA CCAACAACCC CCGGGGACGA CGCGGGGGGC GG 5033

(2) INFORMATION FOR SEQ ID NO: 88:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 117 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 88:

Val Leu Leu Asp Ala Pro Ala Pro Thr Ala Ser Gly Arg Thr Lys Thr

1 5 10 15

Pro Ala Gin Gly Leu Ala Lys Glu Val Gin Phe Ser Thr Ala Pro Pro 20 25 30 Ser Pro Thr Ala Pro Trp Thr Pro Arg Val Ala Gly Phe Asn Lys Arg 35 40 45

Val Phe Cys Ala Ala Val Gly Arg Leu Ala Ala Thr His Ala Arg Leu

50 55 60

Ala Ala Val Gin Leu Trp Asp Met Ser Arg Pro His Thr Asp Gly Asp 65 70 75 80

Leu Asn Glu Leu Leu Asp Leu Thr Thr Ile Arg Val Thr Val Cys Glu

85 90 95

Gly Lys Asn Leu Leu Gin Arg Ala Asn Glu Leu Val Asn Pro Asp Ala 100 105 110 Ala Gin Gly Ile Leu 115

(2) INFORMATION FOR SEQ ID NO: 89:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 131 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 89: Met Thr Ser Arg Arg Ser Val Lys Ser Cys Pro Arg Glu Ala Pro Arg

1 5 10 15

Gly Thr His Glu Glu Leu Tyr Tyr Gly Pro Val Ser Pro Ala Asp Pro 20 25 30

Glu Ser Pro Arg Asp Asp Phe Arg Arg Gly Ala Gly Pro Met Arg Ala

35 40 45 Arg Pro Arg Gly Glu Val Arg Phe Leu His Tyr Asp Glu Ala Gly Tyr 50 55 60 Ala Leu Tyr Arg Asp Ser Ser Ser Ser Glu Asp Asn Asp Glu Ser Arg 65 70 75 80

Asp Thr Ala Arg Pro Arg Arg Ser Ala Ser Val Ala Gly Ser His Gly

85 90 95 Pro Gly Pro Ala Arg Ala Pro Pro Pro Pro Gly Gly Pro Val Gly Ala 100 105 110

Gly Gly Arg Ser His Ala Pro Pro Ala Arg Thr Pro Lys Met Thr Arg

115 120 125 Gly Ala Pro 130

(2) INFORMATION FOR SEQ ID NO: 90:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 363 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 90:

Met Ser Gin Trp Gly Pro Arg Ala Ile Leu Val Gin Thr Asp Ser Thr 1 5 10 15 Asn Arg Asn Ala Asp Gly Asp Trp Gin Ala Ala Val Ala Ile Arg Gly 20 25 30

Gly Gly Val Val Gin Leu Asn Met Val Asn Lys Arg Ala Val Asp Phe

35 40 45

Thr Pro Ala Glu Cys Gly Asp Ser Glu Trp Ala Val Gly Arg Val Ser 50 55 60

Leu Gly Leu Arg Met Ala Met Pro Arg Asp Phe Cys Ala Ile Ile His 65 70 75 80

Ala Pro Ala Val Ser Gly Pro Gly Pro His Val Met Leu Gly Leu Val 85 90 95

His Ser Gly Tyr Arg Gly Thr Val Leu Ala Val Val Val Ser Pro Asn

100 . 105 110

Gly Thr Arg Gly Phe Ala Pro Gly Ala Leu Arg Val Asp Val Thr Phe 115 120 125

Leu Asp Ile Arg Ala Thr Pro Pro Thr Leu Thr Glu Pro Ser Ser Leu

130 135 140

His Arg Phe Pro Gin Leu Ala Pro Ser Pro Leu Ala Gly Leu Arg Glu 145 150 155 160 Asp Pro Trp Leu Asp Gly Ala Thr Ala Gly Gly Ala Val Pro Ala Arg

165 170 175

Arg Arg Gly Gly Ser Leu Val Tyr Ala Gly Glu Leu Thr Gin Val Thr

180 185 190

Thr Glu His Gly Asp Cys Val His Glu Ala Pro Ala Phe Leu Pro Lys 195 200 205

Arg Glu Glu Asp Ala Gly Phe Asp Ile Leu Ile His Arg Ala Val Thr

210 215 220

Val Pro Ala Asn Gly Ala Thr Val Ile Gin Pro Ser Leu Arg Val Leu 225 230 235 240 Arg Ala Ala Asp Gly Pro Glu Ala Cys Tyr Val Leu Gly Arg Ser Ser

245 250 255

Leu Asn Arg Leu Leu Val Met Pro Thr Arg Trp Pro Ser Gly His Ala

260 265 270

Cys Ala Phe Val Val Cys Asn Leu Thr Gly Val Pro Val Thr Leu Gin 275 280 285

Ala Gly Ser Lys Val Ala Gin Leu Leu Val Ala Gly Thr His Ala Leu

290 295 300

Pro Trp Ile Pro Pro Asp Asn Ile His Glu Asp Gly Ala Phe Arg Ala 305 310 315 320 Tyr Pro Arg Gly Val Pro Asp Ala Thr Ala Thr Pro Arg Asp Pro Pro

325 330 335

Ile Leu Val Phe Thr Asn Glu Phe Asp Ala Asp Ala Pro Pro Ser Lys

340 345 350

Arg Gly Ala Gly Gly Phe Gly Ser Thr Gly Ile 355 360

(2) INFORMATION FOR SEQ ID NO: 91:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 251 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 91:

Val Gly Trp Gly Lys Ala Gly Ala Glu Pro Arg Ala Cys Ser Gly Met

1 5 10 15

Ala Ser Leu Leu Gly Val Leu Cys Gly Trp Gly Trp Glu Glu Gin Gin 20 25 30 Tyr Glu Met Ile Arg Ala Ala Asp Pro Pro Ser Glu Ala Glu Pro Arg 35 40 45

Leu Gin Glu Ala Val Val Asn Ala Leu Leu Pro Ala Pro Ile Thr Leu

50 55 60

Asp Asp Ala Leu Glu Ser Leu Asp Asp Thr Arg Arg Leu Val Lys Ala 65 70 75 80

Arg Ala Arg Thr Tyr His Ala Cys Met Val Asn Leu Glu Arg Leu Ala

85 90 95

Arg His His Pro Gly Leu Glu Gly Ser Thr Ile Asp Gly Ala Val Ala 100 105 110 Ala His Arg Asp Lys Met Arg Arg Leu Ala Asp Thr Cys Met Ala Thr 115 120 125

Ile Leu Gin Met Tyr Met Ser Val Gly Ala Ala Asp Lys Ser Ala Asp

130 135 140

Val Leu Val Ser Gin Ala Ile Arg Ser Met Ala Glu Ser Asp Val Val 145 150 155 160

Met Glu Asp Val Ala Ile Ala Glu Arg Ala Leu Gly Leu Ser Thr Ser

165 170 175

Ala Gly Gly Thr Arg Thr Ala Gly Leu Gly Ala Thr Glu Ala Pro Pro 180 185 190 Gly Pro Thr Arg Ala Gin Ala Pro Glu Val Ala Ser Val Pro Val Thr 195 200 205

His Ala Gly Asp Arg Ser Pro Val Arg Pro Gly Pro Val Pro Pro Ala

210 215 220

Asp Pro Thr Pro Asp Pro Arg His Arg Thr Ser Ala Pro Lys Arg Gin 225 230 235 240

Ala Ser Ser Thr Glu Ala Pro Leu Leu Leu Ala 245 250

(2) INFORMATION FOR SEQ ID NO: 92:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 710 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 92:

Val Thr Gly Thr Asp Ala Thr Ser Gly Ala Cys Ala Leu Val Gly Pro 1 5 10 15 Gly Gly Ala Ser Val Ala Pro Ser Pro Ala Val Arg Val Pro Pro Ala 20 25 30

Arg Ala Glu Val Glu Arg Pro Arg Ala Arg Ser Ala Ile Ala Thr Ser

35 40 45

Ser Met Thr Thr Ser Leu Ser Ala Met Leu Arg Met Ala Trp Glu Thr 50 55 60

Ser Thr Ser Ala Asp Leu Ser Ala Ala Pro Thr Asp Met Tyr Ile Cys 65 70 75 80

Arg Met Val Ala Met His Val Ser Ala Arg Arg Arg Ile Leu Ser Arg 85 90 95 Cys Ala Ala Thr Ala Pro Ser Met Val Glu Pro Ser Ser Pro Gly Trp 100 105 110

Trp Arg Ala Ser Leu Ser Arg Leu Thr Met Gin Ala Trp Tyr Val Arg

115 120 125

Ala Arg Ala Arg Ala Phe Thr Arg Arg Arg Val Ser Ser Ser Asp Ser 130 135 140

Arg Ala Ser Ser Ser Val Met Gly Ala Gly Lys Ser Ala Leu Thr Thr

145 150 155 160

Ala Arg Ala Ser Cys Ser Arg Gly Ser Ala Ser Glu Gly Gly Ser Ala

165 170 175 Ala Arg Ile Ile Ser Tyr Cys Cys Ser Ser Gly Arg Val Pro Gin Pro

180 185 190

His Ser Thr Pro Ser Arg Asp Ala Ile Pro Glu His Arg Ser Ala Pro

195 200 205

Ala Phe Pro His Pro Thr Pro Ser Gly Phe Ala Gly Ala Met Gly Thr 210 215 220

Glu Asp Cys Asp His Glu Gly Arg Ser Val Ala Ala Pro Val Glu Val 225 230 235 240

Met Ala Leu Tyr Ala Thr Asp Gly Cys Val Ile Thr Ser Ser Leu Ala 245 250 255 Leu Leu Thr Asn Cys Leu Leu Gly Ala Glu Pro Leu Tyr Ile Phe Ser 260 265 270

Tyr Asp Ala Tyr Arg Pro Asp Ala Pro Asn Gly Pro Thr Gly Ala Pro 275 280 285 Thr Glu Gin Glu Arg Phe Glu Gly Ser Arg Ala Leu Tyr Arg Asp Ala

290 295 300

Gly Gin Gly Asp Ser Phe Arg Val Thr Phe Cys Leu Leu Gly Thr Glu 305 310 315 320 Val Gly Val Thr His His Pro Lys Gly Arg Trp Met Phe Val Cys Arg

325 330 335

Phe Glu Arg Ala Asp Asp Val Ala Val Leu Gin Asp Ala Leu Gly Arg

340 345 350

Gly Thr Pro Leu Leu Pro Ala His Ile Thr Ala Thr Leu Asp Leu Glu 355 360 365

Ala Thr Phe Ala Leu His Ala Asn Ile Ile Met Ala Leu Thr Val Ala

370 375 380

Ile Val His Asn Ala Pro Ala Arg Ile Gly Ser Gly Ser Thr Ala Pro 385 390 395 400 Leu Tyr Glu Pro Gly Glu Ser Met Arg Ser Val Val Gly Arg Met Ser

405 410 415

Leu Gly Gin Arg Gly Leu Thr Thr Leu Phe Val His His Lys Ala Arg

420 425 430

Val Leu Ala Ala Tyr Arg Arg Ala Tyr Tyr Gly Ser Ala Gin Ser Pro 435 440 445

Phe Trp Phe Leu Ser Lys Phe Gly Pro Asp Lys Lys Ser Leu Val Leu

450 455 460

Ala Ala Arg Tyr Tyr Leu Leu Gin Ala Pro Arg Leu Gly Gly Ala Gly 465 470 475 480 Ala Thr Tyr Asp Leu Gin Ala Val Lys Asp Ile Cys Ala Thr Tyr Ala

485 490 495

Ile Pro His Asp Pro Arg Pro Asp Thr Leu Ser Ala Ala Ser Leu Thr

500 505 510

Ser Phe Ala Ala Ile Thr Arg Phe Cys Cys Thr Ser Gin Tyr Ser Arg 515 520 525

Gly Ala Ala Ala Ala Gly Phe Pro Leu Tyr Val Glu Arg Arg Ile Ala

530 535 540

Ala Asp Val Arg Glu Thr Gly Ala Leu Glu Lys Phe Ile Ala His Asp 545 550 555 560 Arg Ser Cys Leu Arg Val Ser Asp Arg Glu Phe Ile Thr Tyr Ile Tyr

565 570 575

Leu Ala His Phe Glu Cys Phe Ser Pro Pro Arg Leu Ala Thr His Leu

580 585 590

Arg Ala Val Thr Thr His Asp Pro Ser Pro Ala Ala Ser Thr Glu Gin 595 600 605

Pro Ser Pro Leu Gly Arg Glu Ala Val Glu Gin Phe Phe Arg His Val

610 615 620

Arg Ala Gin Leu Asn Ile Arg Glu Tyr Val Lys Gin Asn Val Thr Pro 625 630 635 640

Arg Glu Thr Ala Gly Asp Ala Ala Ala Ala Tyr Leu Arg Ala Arg Thr

645 - 650 655

Tyr Ala Pro Ala Ala Leu Thr Pro Ala Pro Ala Tyr Cys Gly Val Ala 660 665 670

Asp Ser Ser Thr Lys Met Met Gly Arg Leu Ala Glu Ala Glu Arg Leu

675 680 685

Leu Val Pro His Gly Trp Pro Ala Phe Ala Pro Thr Thr Pro Gly Asp 690 695 700 Asp Ala Gly Gly Gly Ile 705 710

(2) INFORMATION FOR SEQ ID NO: 93:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5742 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 93:

AGAGGAGTAG AATAGAGAAG AGGATAGAGA GGAGTAGAGT GATCAATAAG ATGTGAAATA 60 TGAGAGAGTA GTAAAGTAGT AAAGAATTTG GGACGGAGCG TAGACAGATA GATATAGAGA 120

TATGGCCGTC TAGGAAGAAG AAATGTGTGA GAGATATAAA GTGGGTAAGA GGTCTATATG 180

AAGAGTAACG AGTAAGGGAT GGGTAGAAGA AGCCTGATGG GGAAGGTGAG AAGAAGTGTT 240

AAAGGGGATA GAATGGAGGT TAGCGAGGTG GTAGAAACAA GAAGGGGAAT AGGAAGGAAC 300

GGCCAATAGG AGAAAGAAGA GGAATGATGG AGGGAAGATG AGGTAGGAGC CATCCCGGCC 360 CACATTTACG GAAAACAGAC CAACGTGCAG GTCGCGACGG AGTTCGATAT GGAAGTAGAA 420

GTTCTCCGCG GCGCGGTCCC AAATCGGCAC CAGCAGGGAA GCATTTACAA AAGCGTACCG 480

GGTCGGAGGC CCGCCGCCCT GGTACGTGTA CGTGTACAAC CCGCACGTCT TTGGGGACGG 540

CGGCTCGCCG CCGCGACACC CTCCATACTG CCGAAGGAGG ATGGGCTGAC GGCAGGCGCG 600

GGTGAGCCGG TATTACGTCA CACGGGCCGC ATACGTTGCG TTGGGTGCGC CAAATCCGCG 660 TACCGGCGGC GCCAGCAAAA CCAGCCCCCC CGTGAGGAAC GAGCGGCCCA GGGGCTCGTG 720

ACGGACGACG CGCCGGGGCA GGTCTTGCCG CCCGGCGTCC GCGGAACCCA AGGGCCCGGG 780

ATCGTCCAAC CGGGGATAGG CATAACAATA TTGAGCCACG GGGGAACCTC CCGGGAAAAC 840

AACATCGTTG TTGGGGGGAT TAATTGGTCC GGGGACACCC GACCCGCCGC GTGTCCCCGG 900

AAGACCAGAA AGAACAAAAA GAAGAAGCAA CCTGGGAGCG ATGGCGTGCA TGACGCCGGG 960 CGGCAAGGTG CCAAAAACAC CAAAGCCCGA GGGCCGCGTC TTTTTGTGCA AAAACATCCA 1020

ACCAGCCCCC CCTCCACGCC CCCCGGGGGG AGCGGGGTCA CTTAGGGTGA AATAGCGGCA 1080

GGCGCAGCAA CTCCGCGGCG CTTGGGCGGA GCGCCGCGTC AAAGGTAAGG GCTTTGCAGA 1140

TGAGATATTC GACGTCTGTG TGGATCTTGT AGTAGCGGGT CCATGCCGGT CGGGTCCACG 1200 CCGGACGATT GTTCCCGGCC GCCCGCGAGC GGTAGTGCGC GGTGAGGCGC GATTCCGCGT 1260

GCGTTGGAAA CTCGTCGACG TGTACCTGGG CCTGTCGGAT GATGCGCGCG ATCTGGTTGT 1320

CGCACGGCCG CCTTTCGGGG TCGCGCGGGG CCGAGAACAA GGACGCGGTG TGGACGGCGG 1380

TCTCAAAGAT CACCAGGCCG GCGCTCCAGA TGTCGATTAC CTGGGTGTAC GGATCCCCGG 1440 CCAGGACCTC GGGGGCGTTT GTATCGATGG TGCCTGCGAT CCCGTAATGG AAGGGGCTCG 1500

ATCGACACCC GCGCACAAAG CACGCCGCCC CAAAGTCCCC CAGACAGATG TTCTCGGGGG 1560

TGTTGATGAG GATGTTCTCG GTCTTAATAT CGCGGTGGAT GATGCCTTCG CAGTGGACGT 1620

AGTCGATGGC GCTCAAGAGC TGCCGGGAGA CCGCGGTTAT CTGTAGGTGG CCCAACGGAG 1680

ACGGGCGCTT GCTCAGATAG GTATACAGGT CGCAGTGATA CTTGGGGAGG ACCAGACACG 1740 TGACCCCAGA AACGACGTGC AGGTCCAGGA GGGGTAGGAT CGCGGGGTGG TTCAGGCGTC 1800

TCAGCAGCCG CGCCTCGTGG TTTGTGCTGG CGTACCACCC CGCCTTGACG ATTACCCGAT 1860

GAGGGTAGTT CGGGTGGCTG CTATCAAAGA CACACCCCTC CGACCCCGGG ATGAGCGTTC 1920

CGTGGATCGC GAATCCCAGC CCCGTCACCA GTTTTGCCAG GGTCGAAGGG GGCTTGCACC 1980

CGCGGCTGAT GGCCCGAAGT GCCTCCCGGT CCATGGTGTC GAGCTCTTCC GGGGTGAACC 2040 CCGTGGCCCC CATCTTACCG CTGTCGCAGG TCCGGACGTC GGGGGGGGCT GCGCGGCCCG 2100

GAACAGGAGG ATGGCCGCTG GCTCCGGGCA GGGGGGCGGC CGAAACCATG GACAGAAAAC 2160

GCCCCTCCGC GTAGTCCTCC GGGTAGGCCA CGTCATCCGG GGCGTCATCG TCGGCCTCGT 2220

CTTCCTCCTC CGCACCCGCG GCGTCCACGA TGGGGTAGTC CTCGTCGCTG TGCATCTGGG 2280

CCAAGATCTC CTGCAGCTGA CACAGGCGCG CAGCCTCGCC GGGGGACGGT GGGCGGGAAG 2340 GGTGGATGGT TTCCGGGGGC CCGGGGGCCA GGTACGCATC CTCCGCGGGG GTATAAAAGG 2400

TGCTCGCCGG GAAGGCCGGG GCCGTGTTTG TCTCCGGCGG GACGGACGCC TCCTGTCTCT 2460

TGTCGGGTCT ACGGTAGACC CCACAGAACT TACGACAGGC CATTCGCCGC GTCGCGCGTG 2520

CCAACCAACG AGCACCCCGA GCGACGGGCC CCGGTGTTTT AAGAAGCGGC AGTTTGTCGA 2580

CACACCCCCC CACTACCCCC GCCCCCTATA TCCGGAACGT CAGATTATCC GGGATACCTA 2640 GCCAACCAAA CAAGGCTGAA AAAATCGAAC GTGCGAACGG GCCGTGTGAT AGCAAGCAGC 2700

CCCCCCGGGT CCGCGCGCCG TCCCGCCGTG CATAGGTCCG CAGACAGGCG AGTGAGTGAA 2760

GATCGGACCA CGGGCCTAAT ATACCGACAT GGGCGTTGTT GTTGTAAGTG TGGTTACCCT 2820

CCTAAACCAA CGAAACGCCC TGCCGCGGAC TTCCGCTGAC GCAAGCCCGG CTCTGTGGAG 2880

TTTTCTGCTT CGGCAATGCC GGATCCTGGC CTCCGAGCCT CTGGGAACCC CGGTGGTGGT 2940 TCGCCCGGCG AACCTTCGCA GGCTGGCCGA GCCTCTGATG GACTTGCCCA AATTCACCCG 3000

ACCGATCGTG CGAACCCGCT CCTGTCGCTG TCCCCCAAAC ACCACGACGG GCCTGTTTGC 3060

GGAGGACGAC CCCCTGGAAA GCATCGAGAT TCTGGATGCC CCTGCGTGTT TTCGGCTCCT 3120

GCATCAAGAG CGCCCCGGCC CCCACCGGCT ATACCACCTG TGGGTGGTCG GGGCGGCGGA 3180

CCTGTGTGTG CCGTTTTTAG AGTACGCACA AAAAACCCGG CTGGGGTTTC GCTTCATCGC 3240 CATGAAGACC AACGACGCGT GGGTGGGGGA ACCGTGGCCC CTGCCCGATC GGTTTTTGCC 3300

CGAGCGGACC GTGTCGTGGA CCCCGTTCCC CGCAGCGCCT AATCACCCCC TGGGAAAATC 3360

TCCTTAGCCG ATACGAATAC CAATACGGCG TGGTGGTGCC CGGCGACCGG GAACGCAGCT 3420

GTCTTCGCTG GCTACGGTCC CTCGTGGCTC CTCACAACAA ACCCCGCCCC GCATCATCCC 3480

GCCCGCATCC GGCGACCCAC CCCACGCAGC GCCCGTGTTT TACGTGCATG GGGCGACCCG 3540 AGATTCCCGA TGAGCCCTCC TGGCAGACGG GGGACGATGA CCCCCAGAAC CCCGGGCCCC 3600

CGCTGGCCGT TGGCGACGAG TGGCCTCCGT CATCCCACGT TTGCTATCCA ATCACCAACC 3660

TCTAACCCCC CCCCGATGCT AATAAAAAAC ACTGCGCCCC ATTACACGTA CGAGCGGTGT 3720

CGCGTTTGTT TCTTTTTTTG TCGTTCCTTC CTCCACCCCC AGAAAAACCA GACACTCAGA 3780 CACAAAAGCT TTCTTGTAGG GCGTTTATTT TCGTTTGGCA AACACACCGG GCTGGGGGTC 3840

CCGCGCTCAT GGCCGGAGAA ATGTGTGGCC GCAGGGATAG GGGCAGGCGG CGGGGAAGCG 3900

CATTTTTCGG CACCCGTCCT CGCGTTCTGG GGCTTCCGTT GCGCGACACG CGCCCGGGGC 3960

GGGTAGGCCA GAGCGTTCGG CGGAGCTGGT ATCGGCGACC ACCGCGGACA GCCAGGGCTG 4020 GGAGCCCTCC TCGGACGTCC AGTCAAACGT CCCAAACTCA CACTCCAGCC GAGCCGCGAT 4080

AGCCCCGCCG GACGCGGATT CCGGGTTCTC CCGGCCGGCC GGGGAGGGCC CCCCCTCCGT 4140

GTCGGAATGG GACGCGAGGG TATCGTCCGA GTCCGTCGCA TCCGATATCT CATCATCGCT 4200

CGTCGAGCCG CCGTTGGTCT CGAGATTGCC AACATCACAC TCGGGGCCGT AACGCCTGGC 4260

GTTCAGACAG GGCAGCTCGC ACACGGGCTC GGCGGCGGGT TCAAAACGCG CCTCGACCTC 4320 CCGGATTGCG TTTCGCAGGC GCACGTCCCA GGTTCCGCCC GAGATCTGCA GCAGGCGGCC 4380

CCACGTGCGC GGCCCCAGGC GGGTCCGGCA GTAGCCCATA AGGTAGCAGT CTCGCACCAG 4440

GTGGCGCAGG CGGTTGGCGC TGCCGGGCGG GTTCGGGGCG GCACGCAGGA TCCGAAAGAG 4500

CTGGTTGACG CACTGGCGTA TGTAATGCAG ATCAAGCGTC CAGGCGGCTC CGCTCCGCAT 4560

CTGGGCCTGG CGAGCAGAGC GCCGCGGTGC GGCTGCGCGA TCCCCGGAAG ACTGGGCCGG 4620 GGCCTGGGGT TGCGCCGCGC GGATAGGTCT GTCGTTTCTC CACACCTCGG GGAAAACCAC 4680

ACCCGCGCGC CGGTCGGGGG AGCTCGTTAA TCGCAGGTTG ATTCGGGGTC GCTTGGATTT 4740

ACGGGGGGGG GTGTCAACCA ACCAGCCGTC TGACGCATCA TCATCATCGT CGTCCGACGG 4800

CCCCGTTCCC TCCGATTCCG TCCCCGTGGT CGATTCTGCC GACAGATCCA AAAAATACCT 4860

CCCCCCGAGC TCCCGCGGGG AGCGACGGCG CCCGCCGCGT AGGTCTCCCG CCTCATCCTC 4920 GGACGACTCG GTCGAGGAGG ATTCCGATTC TGTGTCGGGC TTACCCTCAG ATTCCGACGA 4980

GCTGGGGAGG ACGGGGCGTC TGCGCTTCCG TGAACCCGGG GGTGGGGATG GGGGAGCATG 5040

ATTCGCAGGC GTCGTGTTGA CCGCGGGCGG GTCCGGGGGG ATGTCTGCCA TAGTGGCGAC 5100

GCCTTGTCGC CAGTTACCAC ACCGGTGTCC CGTCCACGAA GGCGGCGCCC GGCCTGCGAT 5160

AAAGCGCGGA TGTTGGGATC GGGGCCCCCC CCCCCCGTCT CCCTTTTCCC CTCTCTTCTC 5220 TCTCCCTCCT CCCTCCCCCC CTCCTCTGTC TCTCTCCCCT TTTTCCCTCA CCTCCCCCTC 5280

TTCTCCTCCC TCCTCCTCCT TCCCTTTCCC CTCCCCTCCC TCTCTCTTCC TCCTTCTCCT 5340

CCCCTCTTTC TTCTTCTTCC CTCTCTCCCT TTCCCCCACT CTCATTCTTC CCACTTCGCT 5400

CCCTTTTCTC TCTCTTCCCT TCTTTTCCTT TTCCCTACCC TCTCCCTTCT TCTTCCGTCT 5460

CCCCTCCCCT TCTCTCCTCT CTCTCTCCTC GTCTTTGTAT CCACGCTACC TCCTCTTCAT 5520 CTCATCTCTT TCTTCCTCTC TTCTCCTCCC TCTCCCCTCT TTTATCTCCC CATTCCTTAC 5580

TCTCTCCTTA TCTCTACCTT TATCTCAACA GCTCTCTCAC GCTCCTCCCA TGGCCATCTC 5640

CTCTCCTTCC TCTCCCCTCC TCTCACATCT CATCCTCTCT TCTCCTTCCA TCTCATCTCC 5700

CATCTCCTGC CCCCACGCTT CTCCCCCTCT CTCTTCTCAC T 5742

(2) INFORMATION FOR SEQ ID NO: 94:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 507 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 94:

Val Gly Gly Cys Val Asp Lys Leu Pro Leu Leu Lys Thr Pro Gly Pro 1 5 10 15

Val Arg Ala Arg Trp Leu Ala Arg Ala Thr Arg Arg Met Ala Cys Arg

20 25 30

Lys Phe Cys Gly Val Tyr Arg Arg Pro Asp Lys Arg Gin Glu Ala Ser 35 40 45 Val Pro Pro Glu Thr Asn Thr Ala Pro Ala Phe Pro Ala Ser Thr Phe 50 55 60

Tyr Thr Pro Ala Glu Asp Ala Tyr Leu Ala Pro Gly Pro Pro Glu Thr 65 70 75 80

Ile His Pro Ser Arg Pro Pro Ser Pro Gly Glu Ala Ala Arg Leu Cys 85 90 95

Gin Leu Gin Glu Ile Leu Ala Gin Met His Ser Asp Glu Asp Tyr Pro

100 105 110

Ile Val Asp Ala Ala Gly Ala Glu Glu Glu Asp Glu Ala Asp Asp Asp 115 120 125 Ala Pro Asp Asp Val Ala Tyr Pro Glu Asp Tyr Ala Glu Gly Arg Phe 130 135 140

Leu Ser Met Val Ser Ala Ala Pro Leu Pro Gly Ala Ser Gly His Pro 145 150 155 160

Pro Val Pro Gly Arg Ala Ala Pro Pro Asp Val Arg Thr Cys Asp Ser 165 170 175

Gly Lys Met Gly Ala Thr Gly Phe Thr Pro Glu Glu Leu Asp Thr Met

180 185 190

Asp Arg Glu Ala Leu Arg Ala Ile Ser Arg Gly Cys Lys Pro Pro Ser 195 200 205 Thr Leu Ala Lys Leu Val Thr Gly Leu Gly Phe Ala Ile His Gly Thr 210 215 220

Leu Ile Pro Gly Ser Glu Gly Cys Val Phe Asp Ser Ser His Pro Asn 225 230 235 240

Tyr Pro His Arg Val Ile Val Lys Ala Gly Trp Tyr Ala Ser Thr Asn 245 250 255

His Glu Ala Arg Leu Leu Arg Arg Leu Asn His Pro Ala Ile Leu Pro

260 265 270

Leu Leu Asp Leu His Val Val Ser Gly Val Thr Cys Leu Val Leu Pro 275 280 285 Lys Tyr His Cys Asp Leu Tyr Thr Tyr Leu Ser Lys Arg Pro Ser Pro 290 295 300

Leu Gly His Leu Gin Ile Thr Ala Val Ser Arg Gin Leu Leu Ser Ala 305 310 315 320 He Asp Tyr Val His Cys Glu Gly Ile Ile His Arg Asp Ile Lys Thr 325 330 335

Glu Asn Ile Leu Ile Asn Thr Pro Glu Asn Ile Cys Leu Gly Asp Phe

340 345 350

Gly Ala Ala Cys Phe Val Arg Gly Cys Arg Ser Ser Pro Phe His Tyr 355 360 365

Gly lie Ala Gly Thr Ile Asp Thr Asn Ala Pro Glu Val Leu Ala Gly 370 375 380

Asp Pro Tyr Thr Gin Val Ile Asp Ile Trp Ser Ala Gly Leu Val Ile

385 390 395 400

Phe Glu Thr Ala Val His Thr Ala Ser Leu Phe Ser Ala Pro Arg Asp 405 410 415

Pro Glu Arg Arg Pro Cys Asp Asn Gin Ile Ala Arg Ile Ile Arg Gin 420 425 430

Ala Gin Val His Val Asp Glu Phe Pro Thr His Ala Glu Ser Arg Leu

435 440 445

Thr Ala His Tyr Arg Ser Arg Ala Ala Gly Asn Asn Arg Pro Ala Trp 450 455 460

Trp Ala Trp Thr Arg Tyr Tyr Lys Ile His Thr Asp Val Glu Tyr Leu

465 470 475 480

Ile Cys Lys Ala Leu Thr Phe Asp Ala Ala Leu Arg Pro Ser Ala Ala 485 490 495

Glu Leu Leu Arg Leu Pro Leu Phe His Pro Lys 500 505

(2) INFORMATION FOR SEQ ID NO: 95:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 188 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 95:

Met Gly Val Val Val Val Ser Val Val Thr Leu Leu Asn Gin Arg Asn 1 5 10 15 Ala Leu Pro Arg Thr Ser Ala Asp Asp Ala Leu Trp Ser Phe Leu Leu 20 25 30

Arg Gin Cys Arg Ile Leu Ala Ser Glu Pro Leu Gly Thr Pro Val Val 35 40 45 Val Arg Pro Ala Asn Leu Arg Arg Leu Ala Glu Pro Leu Met Asp Leu

50 55 60

Pro Lys Phe Trp Ile Val Arg Thr Arg Ser Cys Arg Cys Pro Pro Asn 65 70 75 80 Thr Thr Thr Gly Leu Phe Ala Glu Asp Asp Pro Leu Glu Ser Ile Glu

85 90 95

Ile Leu Asp Ala Pro Ala Cys Phe Arg Leu Leu His Gin Glu Arg Pro

100 105 110

Gly Pro His Arg Leu Tyr His Leu Trp Val Val Gly Ala Ala Asp Leu 115 120 125

Cys Val Pro Phe Leu Glu Tyr Ala Gin Lys Thr Arg Leu Gly Phe Arg

130 135 140

Phe Ile Ala Met Lys Thr Asn Asp Ala Trp Val Gly Glu Pro Trp Pro 145 150 155 160 Leu Pro Asp Arg Phe Leu Pro Glu Arg Thr Val Ser Trp Thr Pro Phe

165 170 175

Pro Ala Ala Pro Asn His Pro Leu Gly Lys Ser Pro 180 185

(2) INFORMATION FOR SEQ ID NO: 96:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 96:

Met Gly Arg Pro Glu Ile Pro Asp Glu Pro Ser Trp Gin Thr Gly Asp

1 5 10 15

Asp Asp Pro Gin Asn Pro Gly Pro Pro Leu Ala Val Gly Asp Glu Trp 20 25 30

Pro Pro Ser Ser His Val Cys Tyr Pro Ile Thr Asn Leu 35 40 45

(2) INFORMATION FOR SEQ ID NO: 97:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 515 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 97:

Val Gly Arg Met Arg Val Gly Glu Arg Glu Arg Gly Lys Lys Lys Lys 1 5 10 15 Glu Gly Arg Arg Arg Arg Lys Arg Glu Gly Gly Glu Gly Lys Gly Lys 20 25 30

Glu Glu Glu Gly Gly Glu Glu Gly Glu Val Arg Glu Lys Gly Glu Arg

35 40 45

Asp Arg Gly Gly Gly Glu Gly Gly Gly Arg Glu Lys Arg Gly Glu Lys 50 55 60

Gly Asp Gly Gly Gly Gly Pro Arg Ser Gin His Pro Arg Phe Ile Ala 65 70 75 80

Gly Arg Ala Pro Pro Ser Trp Thr Gly His Arg Cys Gly Asn Trp Arg 85 90 95 Gin Gly Val Ala Thr Met Ala Asp Ile Pro Pro Asp Pro Pro Ala Val 100 105 110

Asn Thr Thr Pro Ala Asn His Ala Pro Pro Ser Pro Pro Pro Gly Ser

115 120 125

Arg Lys Arg Arg Arg Pro Val Leu Pro Ser Ser Ser Glu Ser Glu Gly 130 135 140

Lys Pro Asp Thr Glu Ser Glu Ser Ser Ser Thr Glu Ser Ser Glu Asp

145 150 155 160

Glu Ala Gly Asp Leu Arg Gly Gly Arg Arg Arg Ser Pro Arg Glu Leu

165 170 175 Gly Gly Arg Tyr Phe Leu Asp Leu Ser Ala Glu Ser Thr Thr Gly Thr

180 185 190

Glu Ser Glu Gly Thr Gly Pro Ser Asp Asp Asp Asp Asp Asp Ala Ser

195 200 205

Asp Gly Trp Leu Val Asp Thr Pro Pro Arg Lys Ser Lys Arg Pro Arg 210 215 220

Ile Asn Leu Arg Leu Thr Ser Ser Pro Asp Arg Arg Ala Gly Val Val 225 230 235 240

Phe Pro Glu Val Trp Arg Asn Asp Arg Pro Ile Arg Ala Ala Gin Pro 245 250 255 Gin Ala Pro Ala Gin Ser Ser Gly Asp Arg Ala Ala Ala Pro Arg Arg 260 265 270

Ser Ala Arg Gin Ala Gin Met Arg Ser Gly Ala Ala Trp Thr Leu Asp 275 280 285 Leu His Tyr Ile Arg Gin Cys Val Asn Gin Leu Phe Arg Ile Leu Arg

290 295 300

Ala Ala Pro Asn Pro Pro Gly Ser Ala Asn Arg Leu Arg His Leu Val 305 310 315 320 Arg Asp Cys Tyr Leu Met Gly Tyr Cys Arg Thr Arg Leu Gly Pro Arg

325 330 335

Thr Trp Gly Arg Leu Leu Gin Ile Ser Gly Gly Thr Trp Asp Val Arg

340 345 350

Leu Arg Asn Ala Ile Arg Glu Val Glu Ala Arg Phe Glu Pro Ala Ala 355 360 365

Glu Pro Val Cys Glu Leu Pro Cys Leu Asn Ala Arg Arg Tyr Gly Pro

370 375 380

Glu Cys Asp Val Gly Asn Leu Glu Thr Asn Gly Gly Ser Thr Ser Asp 385 390 395 400 Asp Glu Ile Ser Asp Ala Thr Asp Ser Asp Asp Thr Leu Ala Ser His

405 410 415

Ser Asp Thr Glu Gly Gly Pro Ser Pro Ala Gly Arg Glu Asn Pro Glu

420 425 430

Ser Ala Ser Gly Gly Ala Ile Ala Ala Arg Leu Glu Cys Glu Phe Gly 435 440 445

Thr Phe Asp Trp Thr Ser Glu Glu Gly Ser Gin Pro Trp Leu Ser Ala

450 455 460

Val Val Ala Asp Thr Ser Ser Ala Glu Arg Ser Gly Leu Pro Ala Pro 465 470 475 480 Gly Ala Cys Arg Ala Thr Glu Ala Pro Glu Arg Glu Asp Gly Cys Arg

485 490 495

Lys Met Arg Phe Pro Ala Ala Cys Pro Tyr Pro Cys Gly His Thr Phe

500 505 510

Leu Arg Pro 515

(2) INFORMATION FOR SEQ ID NO: 98:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6328 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 98:

TGCGGTCGAC TCTAGAAGAC CCTGTGCACG GGACTCGGTT GGGCGACGTC TGCGGTCTAN 60 TGGTCGGCGT GGGGACCGGC TGTGTGGTGG GTGGGGGAAG CACGTTGGAC TACAACCGAC 120

CACACGACAT GCAGGCTTCT GAGCCGCGAA TCCCCACCAT GGCGTTGGGG GCTGGGCATG 180

CCCACGCATG CAGGGATGAC GGAGATGATA GCGTGATTGA CGCCCCGCCC CCATACGAAA 240

TTGTGGCCGG CGCGAGCGCG GGCCANTTTG TCGTTATTGA TATCGACACC CCCACGGACT 300 CGCCTCCACC GTACTCTGCA GGGACGTCTC CCGTTGGGCT TGTTTCACCG GCTTCTTCCG 360

GTGACGGCGA GGTGTGTGAG CGTGGCCGCT CGCGCCGCGC CGCCTGGCGG GCCGCTCGGC 420

GCGCCAGGCG CCGCGCCGAA CGACGGGCGC GGCGCCGGAG CTTTGGCCCA GGGGGGTTGT 480

TTGTGGAGAC CCCCCTGTTT CTACCGGAAA CTATGATTGG GGCCCACCCT GGCGTGGGAG 540

GCGACCTCCC GTCGGGCCTC CCTACTTACG CAAAGGCGAC CTCGGATCGC CCCCCCACCT 600 ACGCCATGGT CATGGCCGCA TGTCCGACCG AGCCACCGGG CGGGTCCGTG GGGCCGGCCG 660

ACCAACCCCG CGTGCAAAGC TCGCGCACGT GGCGACCCCC GCTCGTCAAT TCGCGAGAGC 720

TGTACCGGGC CCAACGCGCG GCCCGCTGTG CGTCAAGCTC CGACACGCCC CAAGCCCCAG 780

GGTGGTGTGG CGGGACGTGT CGTCATGCGG TTTTTGGGGT GGTCGCGGTG GTCGTCGTTA 840

TCATCTTGGC CTTCCTTTGG CGGTAAGCTT CCCCCCTCCC GCGATACAAC GAATAAAAGT 900 CGCGTTAACA CACACGCTGG TTCGTCGCGT GGTATTTACC GGGTTCCTAT AACCCACAAA 960

CTCACACCGC GTCTGTTTTG GTTGGTTCTC ACTCTTTATT AATGAGGTTG CA ACGGACT 1020

CGGAGGGAAG GGGGTGGGTT ATACCTTGAT TTTGATTTTG ATTTTGTGGC GTCGCTGTTC 1080

TGCCGCGCGA GCGGCCGTGC CGCTTGAGCT TATAAAGCGA AGGTGTTGTA GGGCCGCGGA 1140

TGCCCCGAGC CAGCAGGTTT TGGAGAACGG ATACCGACAG TGACAGTGGT ACACGATACC 1200 GTTTATCGTG TATTCCCCCG CGGGGGATGC ACCGGAGACG TCCTTGATGG TTCCGCAGCT 1260

GAATGGGCCC GTGCACCGCA GCCGCCCCCC ACGCTTATCC TCTAGTTCGC GCAAGACGGG 1320

CGGGTGGTTG ACCAGGTCCG CGAAGTTGCG GAGCTCGGTA ACCAGCGGAA GGGAGTGCTG 1380

CGAGTCCTTG TACACCGCAA AGAAAAAACA GTGGATGGGG CCGCTGGTCG AGCAGGAGGC 1440

GCGGACTAAA TAACTCCGCG CGGCCAGGCA CGCGGGGTCC GTTTTGGTCG TGTGCAGGGC 1500 GTTTTCGGCC TGCCACGTGG CATTCAGACA GTACGGGGGG GCGACGTGGG TGATGTCCGG 1560

GGCCCGTAAA AACAGGTTCG AGAGGGGCGT CGTTGTCATG TTGCGAGGGG GGGGGTCGGT 1620

GAATACGCGT CTGCCGTGAG TTCCTGGACG CGCTATGAAG CGGGCCGGGC CGGGGCCCCA 1680

CATTTATCCG GTGGGTCATC GCCCTCCTCC CACGCGCACG CCGGCATCGC CCCGGAGTCT 1740

CCGCCCCACC CGCCGCGCGC GCCAAGAACA TCACACGGAA CCACTTGGGT TGACGTCAAT 1800 ATGTTTATTC TTGCCTAAAA TAGGGAGTTG CAGTAGAAGT ATTTGCCGTG CACATATAAG 1860

GGGGCGATAG TGTGACTGGC CGTCAGCTCG CACACGCGAC TGGAACACTC CTGGCGGTGC 1920

GTGTCCAGTA TTTCAATGAG ACCCGCCATG CAGGCCCCCG GGATGTAAAA GTGCATCGTC 1980

TCGCCGGCCC CAACCCCCAC GGTCGTGTAG TCGATCTCCG ACACGCCGCG CTCGACGCGG 2040

TTGGCGAGGC GGGCCAGGAT GACCAACACA AAGGAGGCAA TATCCTTAAT GTCCGACAGG 2100 CGTCGCCGCG AGCACAGGTC GTCCAGCCCG CACAGGCCTC GGGCCTTCAG GTAGCACTGC 2160

AGAAAGGGGC GCAGGCGCGT GGCGAGGTTT TCCAGCACGG CGGCCGCCGT TCCGATGATA 2220

GGGTCCTGGG GGCGGAGCGG CAGATTGTGG TGAATGCACA TCTTGCACCA CGCCAGCGTC 2280

TCATCCGCGG ACGCCAGGGC CTCGATGAGA TTTTCCTGGC GCAGCACGCA GTCGCGCATG 2340

GCCTTGGCTG TCGACGCGGC CCGCGGGTTG GCTGCGAATG TGCGGTAGAG GCTCGGGCCG 2400 TGAGCGACCA GGGTTTCCCA GGAAACCCGA CGGGTCTCGG CGTCAAACCC CCCCGCTTGG 2460

GTGGCCAGCA CGGGAGCCCA GGGGCTGTTC GCGGCGGGAA ACGGCATCCC GCCAAAGGGG 2520

TCTTGCATGA CCAGGGCACT GCGTCCAAAG CTTTCGCTGA TGCGCTCGAC CGCCGCGCGC 2580

TCGGATATGG ATCGCAGAAC CGCCCGAACG GCGGGGTCGA TGGTGTCGGC AGAGGGCGCC 2640 TTTCGCTCCG GGACCGGGGC GCGGCCGTCC GCGTGCGGGG GGGTCAGGGA CAGCGCCATC 2700

AGCGGAGGGG GGGCCTGGCG CGTGCCTCGT GGCCGCGGGG CCCCCGGAGA CGTCGAGCTG 2760

CTCCCCTCCG CGCCGCGCCT CGCCGTGGGT GGCGCCGGGG CCGTCCGTCC GCGCCGACGC 2820

GGGGTGGCAA CCCCCTTGGT TGTGGGCGTT TCTGGAGACG CGCCGGCGGG GGTTTGGTGT 2880 GGAGTCGGCG CCGCCGGGGC CGTATTGACC CCGGCCCCGG CGGCGACCTC GCCGCCCGCC 2940

TCGGGGATGC GGTGCCTTGG TCGACGGGGG TTGGATGCGG GCCACCTTCC CCCCGTGCGG 3000

TTCCCGGGGG GAAGCCGACC GCCTGGTCCC GAGGCGCGAC CACACGCCGG TGGTCGCGGG 3060

TGGCGGATCG TCGGCTCCCC GCCGCGCTGC CGGGCGAGGC GTCAAGGCTT CGGGGGTGCC 3120

GGCGTCCTCG GGGCGGGCCG GGGGACCTTT GGGAATCGCC GCGTAGATGG CCTCCGCCCC 3180 TCCGTCTCCG CAGGGGTCTT CCATGTCCTC GTCCGACAAG GAACACTCCC CGCTGCTGTC 3240

GGACTCGGGG TCGTCGCGGC GGCCCTCCTC GTCCCGCTCC AGAGCGTCCT CCTCGAGCTC 3300

GCTGTCGGAC AGGTCCAATC CTAGGTCGAT TAGCATATCA ATGTCGGTAG CCATGTTGTA 3360

GGTCGCCGGG GCTGGGATGG CGGGTGTCCT CCGAGGGGGC GCGTGTCGGA AGAGAGTGGC 3420

CGGGTCCGAA TCGAGGAGCG GCACCGACGC GCAACCGGGG TCGGCACACG GCAGCACACA 3480 GCGCCCAGTG GGCCGGTGGC TGCCCTTATA CCCGCACGAC CGGGGCCGGC TTTCCGAAAC 3540

TCCTCCTTGT CCCTCCCCGT CGGGCGTCAC CGCCCCCGCC CCCGCCGTCC CCAGAAACCA 3600

ATCGGACGCC GAGGGTGGGT TTTATGTATT TAATTAGCAT ACGGCAGGTC TGGGTCCGCC 3660

TTCGCGTACA CGCGTAGGCG GGGGTGCGGA AGCACGCGGT AGGGTGGGGT GTATGCGGAA 3720

GTCGGACGAG CCTGCCTGTG CTGGACCGGG GGAGGGGCAA GCAGACCCGA GGCCGGATCG 3780 GCTCTGTGCA CGATTTTAAT TTGCATGCGA CGTGCGAGGG TGCGTAGGCC CGAGGCGGGT 3840

CGTGTATTTA ATTTGCATGG GCGACTGGGT CCGCCTCTTC CAACGGAAGA GGCGTTACGT 3900

CACAGATCAA ACAGGCGCCG CTGAATCTCC TGTTCGTAGC GAAGCGCCAT AAGCACCACC 3960

CCGGCCACGA CGGCGATATA GCACAGGCGC ACGGCGATAC CGGAGAGGAT GATGGAACAG 4020

CAGCGCCCGC AGACGCCCGA CCACCCTTTG GAGCGCCCCC TGGGGGCCGC TGGTTCCGCG 4080 TTTTTGGGGG CCGAGTCCCG CCGCAGGATG AAATACAGCT CCGTCAGGGC GATGATGGAC 4140

ACGAAACACC AGGTGGTGAT TGTTAGAAAC AGGGGGTATG TGATCGCGCA GGCGCCCCGG 4200

GAGATGAGAG CGGTGCCGAC GATGAGACCG AGGGCCACGA AGCGGAGCAG CAGCTCGCAG 4260

CCCACGATGA CGCCAACGGC CGGGCGGTGG TACAAGAAGG TGACCGGATC CGCCTCGAAC 4320

AGCTGCACCA GGGTCTGGCG TTGAACGGAT AGCTCGCAGA GGAGGCGGGT GATTTTCGTG 4380 TAGGGGTATT GCAAGAACAC GCTCGACACT ATGCGGCCGG CGTAGTTCAA AAGATAGGTC 4440

GCCGGGGCCA CCATGCTGTG CGCGGGACTC ACGACGCCGA ACATGCATCG TCGTTGGTGA 4500

AGGGCGACGA ACGCTAGATA CAGAAACCAA CCGACGACCA CCAGGCGCAT CTGGGTGTCC 4560

CAGAGGGCCT CCAAGCAGTT TACGGCCTCG TGCACGTTCA TGACCCGGCG GCTCATGGCG 4620

CCGGGGATGG CCGGGAGGGA CACGGCCCGA CCTTCGATGA TATTGGCGTA GCAGACGTGG 4680 GCGTGGGGGG TCCATGCCCC GCCGGGGGGG GCGGTCGGCG GGCCCAGAAA CAACAGCGTC 4740

TGGTTTATCT TCATCCACAC GAGGGCGGTA TCGTTGTGTG CCCCGGCGGG GCGCACCGCG 4800

TAAATACATC GGTGGAGCGG ACTGGCACCA AAGACGATGT ACCACGCGAG CACGAGGCCG 4860

TAGGCCGTTA TGAAGATGAC GGTCGTGAGG TGCTGGAGGG AGCGGACCGC GAGCATGGCG 4920

TGCCCGCATC GACGGTAAAC AGCGTGTGCA GGCGGTTGTT ATCGCATTTA GTGGCAAAGC 4980 ACTGCTGACA CAGGGACGCG CATAGGCGGT TGTTGGTCCC GACGCTCAGC GCGAGAAAGG 5040

TCCGGGCCGT CGCGCGACTT GCCCTGCCGT GCTTGAAGCG CAGACACGAG AGGCTTTGGT 5100

TCAGGGCGCC GCGGCCGGGG ATCAGCTGCA GCAGGACCCA GTCGTCCTTA ATGACGGCCC 5160

GGCGAACGGA CACGGCCTGA TATTCCCGCG CGTGCTCGGG AAAGTGGGCC TCGATGCACG 5220 CGACTATTCG CCCCAGCAGT TCTGACGCGA ACCCCTCCAC GGTCTCCCCG GCGTCGGGCC 5280

GCACATCGTA GCGGCCCAGA ACCTCCGTCA GGGTCTCGCG TCGCCCAAAG TGCTCCAGGG 5340

CGTTGCGCGA CGCCTTCTTC TCGAAAAAGC TGACATAGTC CCCGCCCAGG CTGTGGAGGA 5400

CGCGGATCTC CCGCGGGGCC GCGGAAAACA TGGGCGGGGC GTGAAAGTGG AAGCGCCGCG 5460 GGTCGGCGTG CGCGGCGACG AACGCCGGAA CGTCCTCGCA CGCGGGGGGG ATCACGAAGA 5520

CGGGCAATAA CCGGCCGCAC GCGGAGCCGT CGGGGCCGAT TTTGGCGAAA TACGGCAAGC 5580

GCAGGCTGTG GCCGTGGGCG TACACGCCCG TATCGATCAG CAAAAAGTTC TTTACGTGGC 5640

TCCCTACGGC CTCCACGAAG TTGCGGTCCA ACAGCACCGC CTGCTGGATC ACCCTCGCCA 5700

CCCCACGCAT TGTCAGGGAG CCGTGCACAA CGTACGGGGC GGGGACCGGT AGGCACACGC 5760 GCAGCCCGAT CTTGTCGGCG CAGGAACACA CGACGGAGTC CGGTTCGCTG GGCGTCGCCG 5820

CTGGTATCTG TTCGTGTAGC AGGTCGAGGT ACGCGGCCTC GTCGTCCGGG AGGGGGCCGT 5880

GGGTCGTGTC CATGGGGTCC GTGTCCTCCT CCCACTCCTC GTCGCCGTCG TCGCCACCGG 5940

CGTCGGGGAA CCAGTCCCCG TCGCCGTCGT CGCCACCGGC CGAGGGCCCG TCGCCCGCAC 6000

AGACGGGCGG CGCGCGGGGC CGACAGGCGC TTTTGAAAAA ATAACAGGGA TAGGCGTCGG 6060 GGTTTACGCG GGCCGCGGGA AACAACAGNT GAACCGCCGC CAGCGCCCCG CGCATAAAGT 6120

GACCCAGGGC CTCGTGGAGC CGGGGAAAGG GGACGGGCTC CTTCAGGGCG ATGTCCAGAT 6180

CCAGGATGAT GTTCGTAACG GCCAGCGCGG CGTTGAAGAT CTCGTTGCGG TTCACGTACA 6240

TATGGCCCCC GACGGCCAGG CCGCCCGGGG GGAGCGCGGG CCCCGGCGCA AAAGGGCGGT 6300

GACCGGGGAC TTCTAGATCG AATGCAG 6328

(2) INFORMATION FOR SEQ ID NO: 99:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 86 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 99:

Met Val Met Ala Ala Cys Pro Thr Glu Pro Pro Gly Gly Ser Val Gly 1 5 10 15 Pro Ala Asp Gin Pro Arg Val Gin Ser Ser Arg Thr Trp Arg Pro Pro 20 25 30

Leu Val Asn Ser Arg Glu Leu Tyr Arg Ala Gin Arg Ala Ala Arg Cys

35 40 45

Ala Ser Ser Ser Asp Thr Pro Gin Ala Pro Gly Trp Cys Gly Gly Thr 50 55 60

Cys Arg His Ala Val Phe Gly Val Val Ala Val Val Val Val Ile Ile 65 70 75 80

Leu Ala Phe Leu Trp Arg 85

(2) INFORMATION FOR SEQ ID NO: 100:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 212 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 100:

Met Trp Gly Pro Gly Pro Ala Arg Phe Ile Ala Arg Pro Gly Thr His 1 5 10 15

Gly Arg Arg Val Phe Thr Asp Pro Pro Pro Arg Asn Met Thr Thr Thr

20 25 30

Pro Leu Ser Asn Leu Phe Leu Arg Ala Pro Asp Ile Thr His Val Ala 35 40 45

Pro Pro Tyr Cys Leu Asn Ala Thr Trp Gin Ala Glu Asn Ala Leu His

50 55 60

Thr Thr Lys Thr Asp Pro Ala Cys Leu Ala Ala Arg Ser Tyr Leu Val 65 70 75 80 Arg Ala Ser Cys Ser Thr Ser Gly Pro Ile His Cys Phe Phe Phe Ala

85 90 95

Val Tyr Lys Asp Ser Gin His Ser Leu Pro Leu Val Thr Glu Leu Arg

100 105 110

Asn Phe Ala Asp Leu Val Asn His Pro Pro Val Leu Arg Glu Leu Glu 115 120 125

Asp Lys Arg Gly Gly Arg Leu Arg Cys Thr Gly Pro Phe Ser Cys Gly

130 135 140

Thr Ile Lys Asp Val Ser Gly Asp Ala Gly Glu Tyr Thr Ile Asn Gly 145 150 155 160 Ile Val Tyr His Cys His Cys Arg Tyr Pro Phe Ser Lys Thr Cys Trp

165 170 175

Leu Gly Ala Ser Ala Ala Leu Gin His Leu Arg Phe Ile Ser Ser Ser

180 185 190

Gly Thr Ala Ala Arg Ala Ala Glu Gin Arg Arg His Lys Ile Lys Ile 195 200 205

Lys Ile Lys Val 210 ( 2 ) INFORMATION FOR SEQ ID NO : 101 :

( i ) SEQUENCE CHARACTERISTICS : (A) LENGTH : 286 amino acids ( B ) TYPE : amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 101:

Met Ala Leu Ser Leu Thr Pro Pro His Ala Asp Gly Arg Ala Pro Val 1 5 10 15 Pro Glu Arg Lys Ala Pro Ser Ala Asp Thr Ile Asp Pro Ala Val Arg 20 25 30

Ala Val Leu Arg Ser Ile Ser Ala Ala Val Glu Arg Ile Ser Glu Ser

35 40 45

Phe Gly Arg Ser Ala Leu Val Met Gin Asp Pro Phe Gly Gly Met Pro 50 55 60

Phe Pro Ala Ala Asn Ser Pro Trp Ala Pro Val Leu Ala Thr Gin Ala 65 70 75 80

Gly Gly Phe Asp Ala Glu Thr Arg Arg Val Ser Trp Glu Thr Leu Val 85 90 95 Ala His Gly Pro Ser Leu Tyr Arg Thr Phe Ala Ala Asn Pro Arg Ala 100 105 110

Ala Ser Thr Ala Lys Ala Met Arg Asp Cys Val Leu Arg Gin Glu Asn

115 120 125

Leu Ile Glu Ala Ser Ala Asp Glu Thr Leu Ala Trp Cys Lys Met Cys 130 135 140

Ile His His Asn Leu Pro Leu Arg Pro Gin Asp Pro Ile Ile Gly Thr

145 150 155 160

Ala Ala Ala Val Leu Glu Asn Leu Ala Thr Arg Leu Arg Pro Phe Leu

165 170 175 Gin Cys Tyr Leu Lys Arg Leu Cys Gly Leu Asp Asp Leu Cys Ser Arg

180 185 190

Arg Arg Leu Ser Asp Ile Lys Asp Ile Ala Ser Phe Val Leu Val Ile

195 200 205

Leu Ala Arg Leu Ala Asn Arg Val Glu Arg Gly Val Ser Glu Ile Asp 210 215 220

Tyr Thr Thr Val Gly Val Gly Ala Gly Glu Thr Met His Phe Tyr Ile 225 230 235 240

Pro Gly Ala Cys Met Ala Gly Leu lie Glu Ile Leu Asp Thr Gin Glu 245 250 255

Cys Ser Ser Arg Val Cys Glu Leu Thr Ala Ser His Thr Ile Ala Pro

260 265 270

Leu Tyr Val His Gly Lys Tyr Phe Tyr Cys Asn Ser Leu Phe 275 280 285

(2) INFORMATION FOR SEQ ID NO: 102:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 332 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 102:

Met Leu Ala Val Arg Ser Leu Gin His Leu Thr Thr Val Ile Phe Ile 1 5 10 15

Thr Ala Tyr Gly Leu Val Leu Ala Trp Tyr Ile Val Phe Gly Asp Leu

20 25 30

His Arg Cys Ile Tyr Ala Val Arg Pro Ala Gly Ala His Asn Asp Thr 35 40 45 Ala Leu Val Trp Met Lys Ile Asn Gin Thr Leu Leu Phe Leu Gly Pro 50 55 60

Pro Thr Ala Pro Pro Gly Gly Ala Trp Thr Pro His Ala His Val Cys 65 70 75 80

Tyr Ala Asn Ile Ile Glu Gly Arg Ala Val Ser Leu Pro Ala Ile Pro 85 90 95

Gly Ala Met Ser Arg Arg Val Met Asn Val His Glu Ala Val Asn Cys

100 105 110

Leu Glu Ala Leu Trp Asp Thr Gin Met Arg Leu Val Val Val Gly Trp 115 120 125 Phe Leu Tyr Leu Ala Phe Val His Gin Arg Arg Cys Met Phe Gly Val 130 135 140

Val Ser Pro Ala His Ser Met Val Ala Pro Ala Thr Tyr Leu Leu Asn 145 150 155 160

Tyr Ala Gly Arg Ile Val Ser Ser Val Phe Leu Gin Tyr Pro Tyr Thr 165 170 175

Lys Ile Thr Arg Leu Leu Cys Glu Leu Ser Val Gin Arg Gin Thr Leu

180 185 190

Val Gin Leu Phe Glu Ala Asp Pro Val Thr Phe Leu Tyr His Arg Pro 195 200 205

Ala Val Gly Val Ile Val Gly Cys Glu Leu Leu Leu Arg Phe Val Gly 210 215 220

Leu Ile Val Gly Thr Ala Leu Ile Ser Arg Gly Ala Cys Ala Ile Thr

225 230 235 240

Tyr Pro Leu Phe Leu Thr Ile Thr Thr Trp Cys Phe Val Ser Ile Ile 245 250 255

Ala Leu Thr Glu Leu Tyr Phe Ile Leu Arg Arg Asp Ser Ala Pro Lys 260 265 270

Asn Ala Glu Pro Ala Ala Pro Arg Gly Arg Ser Lys Gly Trp Ser Gly

275 280 285

Val Cys Gly Arg Cys Cys Ser Ile Ile Leu Ser Gly Ile Ala Val Arg

290 295 300

Leu Cys Tyr Ile Ala Val Val Ala Gly Val Val Leu Met Ala Leu Arg

305 310 315 320

Tyr Glu Gin Glu Ile Gin Arg Arg Leu Phe Asp Leu 325 330

(2) INFORMATION FOR SEQ ID NO: 103

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 482 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 103:

Ala Ala Phe Asp Leu Glu Val Pro Gly His Arg Pro Phe Ala Pro Gly

1 5 10 15

Pro Ala Leu Pro Pro Gly Gly Leu Ala Val Gly Gly His Met Tyr Val 20 25 30 Asn Arg Asn Glu Ile Phe Asn Ala Ala Val Thr Asn Ile Ile Leu Asp 35 40 45

Leu Asp Ile Ala Leu Lys Glu Pro Val Pro Phe Pro Arg Leu His Glu

50 55 60

Ala Leu Gly His Phe Met Arg Gly Ala Ala Val Xaa Leu Leu Phe Pro 65 70 75 80

Ala Ala Arg Val Asn Pro Asp Ala Tyr Pro Cys Tyr Phe Phe Lys Ser

85 90 95

Ala Cys Arg Pro Arg Ala Pro Pro Val Cys Ala Gly Asp Gly Pro Ser 100 105 110

Ala Gly Gly Asp Asp Gly Asp Gly Asp Trp Phe Pro Asp Ala Gly Gly

115 120 125

Asp Asp Gly Asp Glu Glu Trp Glu Glu Asp Thr Asp Pro Met Asp Thr 130 135 140

Thr His Gly Pro Leu Pro Asp Asp Glu Ala Ala Tyr Leu Asp Leu Leu

145 150 155 160

His Glu Gin Ile Pro Ala Ala Thr Pro Ser Glu Pro Asp Ser Val Val 165 170 175

Cys Ser Cys Ala Asp Lys Ile Gly Leu Arg Val Cys Leu Pro Val Pro 180 185 190

Ala Pro Tyr Val Val His Gly Ser Leu Thr Met Arg Gly Val Ala Arg 195 200 205

Val Ile Gin Gin Ala Val Leu Leu Asp Arg Asn Phe Val Glu Ala Val 210 215 220

Gly Ser His Val Lys Asn Phe Leu Leu Ile Asp Thr Gly Val Tyr Ala

225 230 235 240

His Gly His Ser Leu Arg Leu Pro Tyr Phe Ala Lys Ile Gly Pro Asp 245 250 255

Gly Ser Ala Cys Gly Arg Leu Leu Pro Val Phe Val Ile Pro Pro Ala 260 265 270

Cys Glu Asp Val Pro Ala Phe Val Ala Ala His Ala Asp Pro Arg Arg 275 280 285

Phe His Phe His Ala Pro Pro Met Phe Ser Ala Ala Pro Arg Glu Ile 290 295 300

Arg Val Leu His Ser Leu Gly Gly Asp Tyr Val Ser Phe Phe Glu Lys

305 310 315 320

Lys Ala Ser Arg Asn Ala Leu Glu His Phe Gly Arg Arg Glu Thr Leu 325 330 335

Thr Glu Val Leu Gly Arg Tyr Asp Val Arg Pro Asp Ala Gly Glu Thr 340 345 350

Val Glu Gly Phe Ala Ser Glu Leu Leu Gly Arg Ile Val Ala Cys Ile 355 360 365

Glu Ala His Phe Pro Glu His Ala Arg Glu Tyr Gin Ala Val Ser Val 370 375 380

Arg Arg Ala Val Ile Lys Asp Asp Trp Val Leu Leu Gin Leu Ile Pro

385 390 395 400

Gly Arg Gly Ala Leu Asn Gin Ser Leu Ser Cys Leu Arg Phe Lys His

405 410 415

Gly Arg Ala Ser Arg Ala Thr Ala Arg Thr Phe Leu Ala Leu Ser Val

420 425 430

Gly Thr Asn Asn Arg Leu Cys Ala Ser Leu Cys Gin Gin Cys Phe Ala 435 440 445 Thr Lys Cys Asp Asn Asn Arg Leu His Thr Leu Phe Thr Val Asp Ala

450 455 460

Gly Thr Pro Cys Ser Arg Ser Ala Pro Ser Ser Thr Ser Arg Pro Ser 465 470 475 480

Ser Ser

(2) INFORMATION FOR SEQ ID NO: 104:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10212 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 104:

GAAAGTGGAG GGAAGGGGGG GAGGAGTGGG AGTGGTTAAG GAGGTGGGAG GAGAGAGAGA 60 AGGGAGGGGA GGTGGTGGAG AGTGTGGAGT AAGGAAGGAG AAAGGAGGAG AAGGGAGGGA 120

GTTTGATTGT AGAGGAAAAG AGGTGGGAGA GGAGAGGGGG ATGATGGATG GAGGGTATGG 180

GAGTGGAGGG GGGGGGTGGA GGTGGAGTGG GGGTGGGAGT TAGGGGGTGG GGGGGTGGGG 240

GNTGTGGTGG GTTGGTGGTG GGGGGGTGGT GTTGGGTGGG NTGGGGTGGG TGGGTGGGGG 300

TTTTTTTTTG TTTTTTTTTG TTTTGTTNTT NNTTTTNNNT NNNNNTNNTN NNNNNTTTTT 360 TGGCGCCGGA CCTCACGGAC CCGCTGCTGT TTGCGTACGT CGGATTCCAG GTCGTGAACC 420

ACGGGCTGAT GTTTGTGGTC CCCGACATCG CCGTATACGC GATGCTGGGG GGCGCCGTGT 480

GGATCTCGCT GACGCAGGTG CTTGGGCTCC GGCGCCGCCT TCACAAGGAC CCAGACGCCG 540

GGCCCTGGGC GGCCGCGACC CTGCGGGGCC TCTTTTTCTC CGTCTACGCA TTGGGGTTTG 600

CGGCGGGGGT GCTGGTGCGG CCGCGGATGG CGGCGAGCCG GCGGTCGGGG TGATCGCCAT 660 TTCAAATAAA AGGCACGAGT TCCCCGAATA CCACCGGCGT GTGATGATTT CGCCCTACCG 720

CTCCGATCCC CGGGGGGAGG GGGGAAGGAA ATGGGGGCGG GGGTGCCGTG GACGGGTATA 780

AAGGCCAGGG GGGCAGGCGG GCCCATCACT GTTAGGGTGT TAGGTTGGGA GGTGGCACAA 840

AAAGCGACAC ACCCGTGTTG TAGTTGTCCG CGGGAGGCGG TGGTTTCCGG CAACCCTCCT 900

CGCTGCGCCG GGCGCGCCCA CCGGTCCTTC GCGGGGGCCG GGGCTCTTCT GGTCATGGCC 960 CTTGGACGGG TGGGCCTAGC CGTGGGCCTG TGGGGCCTGC TGTGGGTGGG TGTGGTCGTG 1020

GTGCTGGCCA ATGCCTCCCC CGGACGCACG ATAACGGTGG GCCCGCGGGG GAAAGAGAGC 1080

AATGCCGCCC CCTCCGCGTC CCCGCGGAAC GCATCCGCCC CCCGAACCAC ACCCACGCCC 1140

CCCCAACCCC GCAAGGCGAC AAAAAGTAAG GCCTCCACCG CCAAACCGGC CCCGCCCCCC 1200

AAGACCGGGC CCCCGAAGAC ATCCTCGGAG CCCGTGCGAT GCAACCGCCA CAACCCGCTG 1260 GCCCGGTACG GCTTGCGGGT GCAAATCCGA TGCCGGTTTC CCAACTCCAC CCGCACGGAG 1320

TCCCGCCTCC AGATCTGGCG TTATGCCACG GCGACGGACG CCGAGATCGG AACGGCGCCT 1380

AGCTTAGAGG AGGTGATGGT AAACGTGTCG GCCCCGCCCG GGGGCCAACT GGTGTATGAC 1440

AGCGCCCCCA ACCGAACGGA CCCGCACGTG ATCTGGGCGG AGGGCGCCGG CCCGGGCGCC 1500 AGCCCGCGGC TGTACTCGGT CGTCGGGCCG CTGGGTCGGC AGCGGCTCAT CATCGAAGAG 1560

CTGACCCTGG AGACCCAGGG CATGTACTAC TGGGTGTGGG GCCGGACGGA CCGCCCGTCC 1620

GCGTACGGGA CCTGGGTGCG CGTTCGCGTG TTCCGCCCTC CGTCGCTGAC CATCCACCCC 1680

CACGCGGTGC TGGAGGGCCA GCCGTTTAAG GCGACGTGCA CGGCCGCCAC CTACTACCCG 1740 GGCAACCGCG CGGAGTTCGT CTGGTTCGAG GACGGTCGCC GGGTATTCGA TCCGGCCCAG 1800

ATACACACGC AGACGCAGGA GAACCCCGAC GGCTTTTCCA CCGTCTCCAC CGTGACCTCC 1860

GCGGCCGTCG GCGGCCAGGG CCCCCCGCGC ACCTTCACCT GCCAGCTGAC GTGGCACCGC 1920

GACTCCGTGT CGTTCTCTCG GCGCAACGCC AGCGGCACGG CATCGGTGCT GCCGCGGCCA 1980

ACCATTACCA TGGAGTTTAC GGGCGACCAT GCGGTCTGCA CGGCCGGCTG TGTGCCCGAG 2040 GGGGTGACGT TTGCCTGGTT CCTGGGGGAC GACTCCTCGC CGGCGGAGAA GGTGGCCGTC 2100

GCGTCCCAGA CATCGTGCGG GCGCCCCGGC ACCGCCACGA TCCGCTCCAC CCTGCCGGTC 2160

TCGTACGAGC AGACCGAGTA CATCTGCCGG CTGGCGGGAT ACCCGGACGG AATTCCGGTC 2220

CTAGAGCACC ACGGCAGCCA CCAGCCCCCG CCGCGGGACC CCACCGAGCG GCAGGTGATC 2280

CGGGCGGTGG AGGGGGCGGG GATCGGAGTG GCTGTCCTTG TCGCGGTGGT TCTGGCCGGG 2340 ACCGCGGTAG TGTACCTCAC CCACGCCTCC TCGGTGCGCT ATCGTCGGCT GCGGTAACTC 2400

CGGGGCCGGG CCCGGCCGCC GGTTGTCTTC TTTTCCACCC CTTCCGTCCC CCGTACCCAC 2460

CACACCCCAC CCCACCCCCC CGCCGTCCCC CGGGCGTTAT AAGCCGCCGC ACTCGCTTTT 2520

CCCACCGGAA AATCCTCGGC CCGATCCGAA CGGCGCACGC CGCGTGGGCT CCAAACGCCT 2580

CCGCGAAGAG AGCGCCCCGC CCCGATATTC AAGCCCGCGG TGGTGCTATG GCTTTCCGTG 2640 CTTCGGGACC CGCCTACCAG CCCCTCGCCC CCGCGGCCTC CCCGGCGCGG GCTCGTGTTC 2700

CGGCCGTGGC CTGGATCGGC GTCGGAGCGA TCGTCGGGGC CTTTGCGCTC GTCGCCGCGT 2760

TGGTTCTCGT ACCCCCTCGG TCCTCGTGGG GACTCTCGCC GTGCGACAGC GGCTGGCAGG 2820

AATTCAACGC GGGATGCGTC GCGTGGGACC CCACCCCCGT CGAGCACGAG CAGGCGGTCG 2880

GCGGCTGCAG CGCGCCGGCC ACCCTTATCC CCCGTGCGGC CGCCAAGCAC CTGGCCGCTC 2940 TGACACGCGT CCAGGCGGAG AGATCGTCGG GTTACTGGTG GGTGAACGGA GACGGCATCC 3000

GGACCTGTCT GAGACTCGTC GACAGCGTCA GTGGCATCGA CGAGTTTTGC GAGGAGCTCG 3060

CGATCCGCAT ATGCTACTAC CCACGAAGCC CCGGCGGGTT TGTCCGCTTC GTAACTTCAA 3120

TACGTAACGC CCTGGGGTTG CCGTGAGGCG CGCGTCCGAC GGTCCCGCTT CTCGCCTCTC 3180

TTCTTCCCCC TCCCCACCCC ACCCACCGAC CAACGACGGC GTTTGGCCAA TACCCTCCTT 3240 TTTTCTTTTT CTCTTCCCCC CCCAAAAAAA AAAACAATAA ACAGCTAATT GCGTACGACA 3300

AACCATGCGG AACTCGCTGT TTTTTTTCCC CTGTTTGTTA CTTTTTATTG AAAACAGACA 3360

TACGGGGAAA GGGGCCGGAA ACCGAGACGG TGGGGCCGGC GGTCGCATTT TTTTAATGGC 3420

TCTGGTGTCG GCCGCGTTTG AGCTTCGTCA ACAGGGCGCT GAGGGCGGCG ACGTTTGTCG 3480

GGCCGTCGTT GGCCAGCGCG TTGGTCCGGG GGCGGGCGGG CATGGGCGAC AGGCTTAGTC 3540 CCGGGTCCGG GGCGCGTGTG GCCCCCGGAG GGGAGAAGAG GGCAGACCCG CCCCAGTCGT 3600

ACAGGGGATT TTCCGCCTCG ATGTACGGGG AGTCCGGGGC GTCTCCCGGC GGGGCCGCCC 3660

CGCCGGCGTC TTGCCGGCGA AGGCAGATGT TTTCGTATAC CCGAACCCAG GGGATCTCCT 3720

CGTAGACGCG CCCCCCATCC TCGCTCACCG ACTCGTAAAT GGAATCTGCC TCCTCGGAGG 3780

GGGCGCGGGG GGCGTGGCTT TCGGCCGGCC AGGCGGCGGC GGTGGTGTCG GCGGCGGGGG 3840 TGGAGCCAAG CCCGACGCCC GCGGGCATGG CGGCGTCATC CTCCGGCAGC AGATACGTGT 3900

TTTCCATCTG GTCCGGTTCG GCCTCCGCGT CTGGCCCCCA GGTCCGCACT GCGTTGTAAA 3960

CCCCGGCGGC CTCGCGATGA GCCGCGAGCG GGCGCGCCGC GGCTGCCGGC CGCTGCTCGG 4020

GGGGCGCGGG GTTGCGGGGC GGGAGGCGCG GGGGCGCCCC GGCCATATGC GTGTAATAAG 4080 TGGCCGGCCG GCCGGCGCAG GGCTCGGGAC CCCGGTCGGC CGCGTCAACG TGCGGGGGCT 4140

CGGGGAGGTC CTCGCGGTGG CGCCTGAACC TCCGAGGGGC CGCGGGGGTC AATTGGGGGC 4200

CACCCCGGGG GAGCGGCGGG GGTGCGTTAT CGCGCCGGGT CCGTTGTATC TTGTCCCGGC 4260

AGCTCCCGCC GACCGCGCCG CGGCCCCCCG GTGGGCCGGA CGCCGCGAGG CGCAGGATGG 4320 ACTCGTAGTG GGGCGACGGG GTTCCGCTCC GAAGCAGGTC CGGGGCCAGG GCGGCCCCTA 4380

ACCACTACTT GATGCTGAGT TCCATCCGGG CCCAGCTCGG GGCGGTCATC GTGGGGAACA 4440

GGGGGGCGGC GGTCCTGCAG AAGCGCTCCT GGCTGTCCAC CGCCGCCCGT AGGTACTCGT 4500

TGTTCAGGCT GTCGGAGGCC CAAACAACAT ACCCGGTAAG CGTCGCGTTA ATTATATACT 4560

GGGCGTGGTG GTGGACTATG GATAGAACCT CGACGGTCGA GACGATGGCG TCCACGATCC 4620 CGTACGTGCC GCCGCTGCGC TTGCCGGTCT CCCACAGGTG GGCCAGGCGC GTCAGGTGGC 4680

CCAGGACGTC GCTGACCGCC GCCCGCAGGG CCATGCACTG CATCGAGCCC GTGGTGCCGC 4740

TGGGCCCGCG GTCCAGGTGG CGCGCAAACG TCTCCGCGGG CGCCTCCAGA CTCCCGCTGA 4800

GCGCCACGAA CCGGCGATCG GCGGGGCCCA GGCGGCGACA CACGTACTTG TCCGCCGTCC 4860

ACAGCATCCA CGAGGCCCAA TGGTACAACA CGGAGACGTA GGCCAGGAGC TCGCTCAGCC 4920 GCAGTGCGGT GTCCGTGCTC GGCCGGCTCG GGTCTGCGGG GCGCATAAAA AACATGTACT 4980

GCTGGAGCCT GTGGGCCGCG TCGCGCAACC CCGCCACCGC GGCGGCGTAC TTGGCCGCGG 5040

CGGCCCCGCT CTTGAACGGG GCGCGCACCA CCAGCTTCGG GAGCAGGGTG GGCCGCATCA 5100

ACACGTGCAG GCTGGGGTCG CANTCGCCCG CCGGGTCGTC GGGGATGTCC AGGCCGCTGG 5160

GCACAACCGT CTGGAGGTAC TTCCAGTACT GCGCTAGGAT GGCGCGGCTC AGCTGGCCGC 5220 CCGACAGCTC CACCTCGCCG AGCGCCTGCT TGGCGGCCGA CGCGTAGTGC CGGATGTAGT 5280

CGTAGTGCGG GTCGCTGGCG AGCCCGTCTA CGATCAGGCT CTCGGGGACG GTGTTATGGT 5340

GCCGCGCCGC CAGCCGGACG CTGCGATCGG CGCCGGTCAG AAACGCCGGC TGCAGGTCGT 5400

CGGCGCGCTG CCGCAGGACG CCCACGGCCG CGCTGAGGAG CCCCTCCGGG GTGGGGAGCA 5460

GACACCCGGC GAAGATGCGC CGCTCGGGGA CGCCCGCGTT GGCGCCGCGG ATGAGGTTGG 5520 CCGGCGTCAG GCACCGCGCC AGCCGCAGGG AGCTCGCGCC GCGCGCCCGG CGTTGCATGG 5580

CGGAGACCGT TCGGTCGGGG GCCCGCCGGT CGGAGGTATG CCGCGTCCCG GGATATAGGG 5640

TTGCTTTTTA TGGGGAGGCG CCTATGGGCG TGGCGGGCCG CCCAGCCCGG TCGCGCGCCT 5700

CCCGGACACG TGCGCCCGGA GGGCGGCGGT CTCCTCGTCG CCCATGAGCA GTTTCCGAAA 5760

CTGCGCCATG ATGTCCACGA CGCGGACCCG CGGCCCCAGC ACGGACTCGC TATTCAGGGG 5820 GGCGGGGGGG AAGGCCGCCA GGTCTTCGAG CAGGAAGGCG GGGTCTGCCG TCCCGCTCAC 5880

GGGCGCCCGG GGCGCCGAGG ACGCGGGGCG AAGGTCCACG TGTTCCGCGG CGGCGCGCAC 5940

GTCCGCCCAA AATTTGGCGG GGGTGGTCCG CGCGTACAGG GGCTGGGTCG CGCGGAGGAC 6000

GCACGCGTAG CGCAGGGGGG TGTACGTGCC CACCTCGGGG GCCGTCGACC CGCCGTCAAA 6060

CGCGGCCAGG GCCACGCACG CGACCACCGT GTCGGCCAGG CCCAGCAGCC GCTGCAGGAT 6120 GAGCCCCGTC GCCAGCACGG CGCGCGCGGC CGCCGCGTTG TCCCTGCGCC GGCGCGCGTC 6180

CCCGCAGGCC AGGGCGTATT TCAGGGTAAC GGTCGCCAGG GCCGTGTGCA GCGCGTACAC 6240

GGCCGCGCCC AGCACGGCGT TCAGCCCGCT GGTGGCGAGC AGGCGGCGCG CCGCGGTGTC 6300

GCCCAGCGCC TCGTGCTCGG CCGCCACGAC CCCGGGGCTA CCCAGGGGCA GGGCGCGAAA 6360

CAGCGCCTCC TGCTCCACGT CCGCAAACGC GGGGTGGGCG GAGTGCGGGT GCAGGCGCGC 6420 CCCCACGACC ACCGAGAGCC ACTGGACCGT CTGCTCCGCC AGGACCGCCA GCACGTCCAG 6480

GACGCGCCCC GCAAACGCGG CCTCCCGCGG GAGCACGCAT TTGACGGCGC CGGGGTTGAA 6540

GCGGGCGAGC AGAGCCCCGG TGGCGATGTA CGTCATGCGC CCCGCGTAGC GGGCGGCCAC 6600

GCGACAGTCG CGCCCCAGGA GCGCGCGCAC CCCGGGCCAG TACAGCAGGG ACCCCAGCGA 6660 ACTGCGAAAG ACCGCGGCGT CGGGGCCGGG GTGGGGGGGC GCGGCCCCTC CCGCGCTGAG 6720

CAGCGGCACG GCGGCGGCCC CCACGGGCCG CAACGCCGTG AGGCTCGCGA ACTGCCGTCG 6780

GAGCTCGGCC GCCCTGTCGT CGAGCTCCGA GCCGCGCCCC TCCGTGTGCA GGCGCGTCCC 6840

GCAGACCCAC CCGTTGATCG CCACCCGCAC GATGGCGTCC ACCAGAAAGC CCATCGCGCG 6900 GGAGGGGCTG GTTTTTGCCC GCCGATCCGT CAGGTCGAGG ATCGCGTCGC CCGTGACGTA 6960

CCAGGCCAGC GCCTCGCCCT GCTGCAGCGT CTGGCGGAAA AACACCTTTG GGTCGGCCGG 7020

GGAGGCAAAG TGCATGACCC CCACGCGCGA CAGCCCGAAC GCGCTATCCG GACACGGGTA 7080

GAACCCGGCC GGATGTCCCA GGGCCAGGGC CGAGCGCACG GACTCGTCCC ACGCGGCGAC 7140

TCGGGGGGTC AGGCGGTCCA GGGGGAATGC CGCCTGCAGC TCCGGGCCCG ACACGCGGCC 7200 CTCTATAATC TCGACCGTCG CGGGAGGCCG CGCCCCGGCG CCGTCATCGT GCGCGACGGC 7260

GGCGGGGTAG TCGTCCTCCT CGTAGCTGAG CTCGTCCAGG AACAGCGGCG AGGGCACCAC 7320

CCGCGAACCG CCCACCCGCC CCAAAACGTC GCGTGGGTCC ATCGGGCCCA GGTAGCCTCC 7380

CCGCGGGGCC CGCGTGATGG CGCTGTCCCG GCGTCCGCGA ACGGACTGGC TCCTGGCCGT 7440

AACGGACCTG GGGCGCGGAA AGGACGCCCG GCGGGGGGGC GCCGCCGCCC GGGCCTCGGA 7500 CGCGCGTCGG GACCCGGGGT GACCGCGGGC CTCCCGGCGA CGGCGCGGGG GCGGCTCTTC 7560

GCTCGCCATC TCCCCCGCGG CCTCGACCTC GCTGTCGTCG TCCACGTTAA ACACCGCCCG 7620

CAGGTACCCC ATTAACCCGA CTCCACCGCC CTCGGGCTCG TCCTCCACGG GCGATTCGGC 7680

GCGATGCGCG GACGGGGCAT GGGACCGGGT GGAGGCGCGC CTCCGGCGTA CGGCATGCCC 7740

GCGCACGGAC ATGGTGGCCG GAGGCCCGAT TTTTTACACA CCCCCTCCCC GCAAACGGAC 7800 AAGGAAAGGG GTGGTGCGAG GGGGGAGGCC CAAACGGGGA GGTGGGGGGT AGGGGGCGGT 7860

CCCAGGGAGC GGGGGGTACG AACCGGCACG ACGGGAACAG AGAAACGCGA CCGCTCCAAC 7920

AAGGGTGGGG GGTGGGCCTC ATCCCCACGC AAACCCGCGG GCAAATGCGA GAACGGGACC 7980

CGCGCGCCTG CCTTTATACG CGGACCCCAG CACCACGAGC CGTTCTGTGA CCCGAATCTA 8040

CACGACCGCG GGCTCGTAGG CGCGACTAAC GCCCAACCCA ACGGCACACA CCCCCCACCC 8100 CGCGCGTAAC CCCATTTCTT TCATGGTCCC GTAATAAACA GCCAACGCAC GCCGCGTATG 8160

ATGAGTTGCT TGCCAATGTT TATTGCTGTG GTTGCGAACC CTCTATCGCG ATACAGACGG 8220

AGGTGAGGCG GGGCGGTGGT GGGGGGGGGG GCGCCCCCCC CGGTCGCACA TCCTACCCCC 8280

CAAAGTCGTC AATGCCCATG GCATCGGTAA ACATCTGTTC AAACTCAAAA TCGTCCACGT 8340

CCAAAGCCCC ATACAAAACG GGGTCGTGGG TCATTCCCGG GGAGGGGGAC TCCACGTCCC 8400 CCAGCATCTC CAAGTCGAAG TCGTCCAGGG CGTCGGCGGG CGTCATATCC ACCTCCTCGC 8460

CGTCCAGGCG GAGTTCGTCT CCCAGGCTGA CGTCGGTAAT GGGGGCGGTG GTGGACAGTC 8520

TGCGGGGGCG TTGTCCCGCG GAGAGAAACG ACATGCGCGG CGCCACCAGC CCGGCCTCCG 8580

CGGGAGCGTC ATCGTCGTCC GGGAGGTCGA GCAGGCCCTC GATTGTCGAT CCGTAATTAT 8640

TTCTGGTCCG CCCGCGGCTA TACGCGTGCT CCCGCATGAC GGACTCGCCC TCCGAGGTCG 8700 CAACGCTGGA GTACGAGTCC AACTTGGCCC GGATCAGCAG CATAAAGTAC CCAGAGGAGC 8760

GGGCCTGGTT GCCCTGCAGG ACGGGCGGGG TCGTGAGGGG CGCCCCGGGT TCCTCCGCCG 8820

CCGCACTTCG CACCAGCGGG AGGTTCAGGT GCTCGCGAAT GTGGTTTAGC TCCCGCAGTC 8880

GCCGGGCCTC CACGGGAACT CCCCGCACGG TGAGCGATCC GTTGATAAAC ATCAGGGGCT 8940

GAAACAGACA CGCCAACTGG CGCCAGCTCT CCAGGTCGCA GCAGAGGCCG TCGAACAGAT 9000 CGGGCCGCAT CATCTGCTCG GCGTACGCGG CCCATAGGAT CTCGCGGCTC AGAAAGAGGT 9060

ATAGATGCAG AAACAGGACG CGCGCCAGGC GCGCGGTCTC GCGGTAGTAC CTGTCCGCGA 9120

TCGTGGTGCG CAGCATCTCC CGCAGGTCGC GGTTGCGGCC CCGCATGTGT GCCTGGCGGT 9180

GTAGCTGCCG AACGCTGGCG CGCAGGTACC GGTACAGGGC CGAGCAAAAA TTTGCCAACA 9240 CGGTCCGGTA GCTCTCCTCC CGCGCCCGCA GCTCACCGCG GAAAAACTGC GCCATGGCCT 9300

CGTAGTACGA AGGCAGCTCG TCGCGGGTGG CGGGCAGGGT GGGGAACGCC ACGTCGCCGT 9360

GGGCGCGAAT GTCGATCGGG GAGCGCTCGG GGACGTGCGC ATCCCCCCAG TCGATCACGT 9420

CGCTGGGCAG CGTCGACAGA AACTTGCACT CCCGGTACAT GTCGGCGTTG GTCGGGAACC 9480 CAGAGAACAG GTCCTCGTTC CAGGTATCTA GCATGGTACA CAGCGCGGGA CCCGCGCTGA 9540

AGCCCAGATC GTCGAGGAGA CGGTTAAACA GGGCCGCGGG GGGGACGGGC ATGGGCGGCG 9600

AGGGCATCAG CTGGGCCTGA CTCAGCCGAC CGGTGGCGTA CAGCGGAGGG GCGGCTGGGG 9660

TGTTCTTGGG ACCCCCGGCT GGCCTGGGGG GCGGTGGCGA AACCCCGTCC GCGTCCGCAA 9720

ACAGATTGTT GACCAACAGG TCCATGGGGG CGGTTGGGTC CGGGGATAAC GATTTTGAGA 9780 GGCGAATGAG AAGTGCCCGA GCGCCCGGCG GCGGAGAGGG GGGGAGGGAT CCGGGACCCG 9840

CGACAGAAAA AGGCCGGGGC CCTTGCGAAG GGAATTGCCG GGGGTGCCGT GCGTCCCCGA 9900

TGACTGACAT CTCTCTTCCT CCCCCCCGCA TTTTTAGTAT CACCCCAATT GCCGCCCCAA 9960

AACCTTCTTG ACTTCCCCCA CCCGTTTCCG TGGCGGCCCC TTCCCCCCTG CTCCTCTGTA 10020

ACGGGATGGT CTTATTCCCT CCTTCCCCTG GCCCTTCCCC CTCCTCTCTT CCTTTTTCCT 10080 TCCCCTTCTT CCGTCACTCC TTCCTCCCCT CTCTCGATTC CTCCCTTCTT CCCCATCTCT 10140

TCCTTCTCCT CTCACTCTCA TATCCTTCAA TACTCTCCTC CTCTCTATCT TTCCCCCCGC 10200

TTCTTCTCTC T 10212

(2) INFORMATION FOR SEQ ID NO: 105:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 148 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 105:

Val Gly Val Gly Val Arg Gly Trp Gly Gly Gly Xaa Cys Gly Gly Leu

1 5 10 15

Val Val Gly Gly Trp Cys Trp Val Xaa Trp Gly Gly Trp Val Gly Val 20 25 30 Phe Phe Cys Phe Phe Leu Phe Cys Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa 35 40 45

Xaa Xaa Phe Leu Ala Pro Asp Leu Thr Asp Pro Leu Leu Phe Ala Tyr

50 55 60

Val Gly Phe Gin Val Val Asn His Gly Leu Met Phe Val Val Pro Asp 65 70 75 80

Ile Ala Val Tyr Ala Met Leu Gly Gly Ala Val Trp Ile Ser Leu Thr

85 90 95

Gin Val Leu Gly Leu Arg Arg Arg Leu His Lys Asp Pro Asp Ala Gly 100 105 110

Pro Trp Ala Ala Ala Thr Leu Arg Gly Leu Phe Phe Ser Val Tyr Ala

115 120 125

Leu Gly Phe Ala Ala Gly Val Leu Val Arg Pro Arg Met Ala Ala Ser

130 135 140

Arg Arg Ser Gly 145

(2) INFORMATION FOR SEQ ID NO: 106:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 538 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 106:

Met Gly Ala Gly Val Pro Trp Thr Gly Ile Lys Arg Ala Gly Gly Pro

1 5 10 15

Ile Thr Val Arg Val Leu Gly Trp Glu Val Ala Gin Lys Ala Thr His 20 25 30 Pro Cys Cys Ser Cys Pro Arg Glu Ala Val Val Ser Gly Asn Pro Pro 35 40 45

Arg Cys Ala Gly Arg Ala His Arg Ser Phe Ala Gly Ala Gly Ala Leu

50 55 60

Leu Val Met Ala Leu Gly Arg Val Gly Leu Ala Val Gly Leu Trp Gly 65 70 75 80

Leu Leu Trp Val Gly Val Val Val Val Leu Ala Asn Asp Gly Arg Thr

85 90 95

Ile Thr Val Gly Pro Arg Gly Lys Glu Ser Asn Ala Ala Pro Ser Asp 100 105 110 Arg Asn Ala Ser Ala Pro Arg Thr Thr Pro Thr Pro Pro Gin Pro Arg 115 120 125

Lys Ala Thr Lys Ser Lys Ala Ser Thr Ala Lys Pro Ala Pro Pro Pro

130 135 140

Lys Thr Gly Pro Pro Lys Thr Ser Ser Glu Pro Val Arg Cys Asn Arg 145 150 155 160

His Asn Pro Leu Ala Arg Tyr Gly Leu Arg Val Gin Ile Arg Cys Arg

165 170 175

Phe Pro Asn Ser Thr Arg Thr Glu Ser Arg Leu Gin Ile Trp Arg Tyr 180 185 190

Ala Thr Ala Thr Asp Ala Glu Ile Gly Thr Ala Pro Ser Leu Glu Glu

195 200 205

Val Met Val Asn Val Ser Ala Pro Pro Gly Gly Gin Leu Val Tyr Asp 210 215 220

Ser Ala Pro Asn Arg Thr Asp Pro His Val Ile Trp Ala Glu Gly Ala

225 230 235 240

Gly Pro Gly Asp Arg Lys Val Val Gly Pro Leu Gly Arg Gin Arg Leu

245 250 255 Ile Ile Glu Glu Leu Thr Leu Glu Thr Gin Gly Met Tyr Tyr Trp Val

260 265 270

Trp Gly Arg Thr Asp Arg Pro Ser Ala Tyr Gly Thr Trp Val Arg Val

275 280 285

Arg Val Phe Arg Pro Pro Ser Leu Thr Ile His Pro His Ala Val Leu 290 295 300

Glu Gly Gin Pro Phe Lys Ala Thr Cys Thr Ala Ala Thr Tyr Tyr Pro

305 310 315 320

Gly Asn Arg Ala Glu Phe Val Trp Phe Glu Asp Gly Arg Arg Val Phe

325 330 335 Asp Pro Ala Gin Ile His Thr Gin Thr Gin Glu Asn Pro Asp Gly Phe

340 345 350

Ser Thr Val Ser Thr Val Thr Ser Ala Ala Val Gly Gly Gin Gly Pro

355 360 365

Pro Arg Thr Phe Thr Cys Gin Leu Thr Trp His Arg Asp Ser Val Ser 370 375 380

Phe Ser Arg Arg Asn Ala Ser Gly Thr Ala Ser Val Leu Pro Arg Pro

385 390 395 400

Thr Ile Thr Met Glu Phe Thr Gly Asp His Ala Val Cys Thr Ala Gly

405 410 415 Cys Val Pro Glu Gly Val Thr Phe Ala Trp Phe Leu Gly Asp Asp Ser

420 425 430

Ser Pro Ala Glu Lys Val Ala Val Ala Ser Gin Thr Ser Cys Gly Arg

435 440 445

Pro Gly Thr Ala Thr Ile Arg Ser Thr Leu Pro Val Ser Tyr Glu Gin 450 455 460

Thr Glu Tyr Ile Cys Arg Leu Ala Gly Tyr Pro Asp Gly Ile Pro Val 465 470 475 480

Leu Glu His His Gly Ser His Gin Pro Pro Pro Arg Asp Pro Thr Glu 485 490 495 Arg Gin Val Ile Arg Ala Val Glu Gly Ala Gly Ile Gly Val Ala Val 500 505 510

Leu Val Ala Val Val Leu Ala Gly Thr Ala Val Val Tyr Leu Thr His 515 520 525 Ala Ser Ser Val Arg Tyr Arg Arg Leu Arg 530 535

(2) INFORMATION FOR SEQ ID NO: 107:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 170 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 107:

Met Ala Phe Arg Ala Ser Gly Pro Ala Tyr Gin Pro Leu Ala Pro Ala

1 5 10 15

Asp Ala Arg Ala Arg Val Pro Ala Val Ala Trp Ile Gly Val Gly Ala 20 25 30 Ile Val Gly Ala Phe Ala Leu Val Ala Ala Leu Val Leu Val Pro Pro 35 40 45

Arg Ser Ser Trp Gly Leu Ser Pro Cys Asp Ser Gly Trp Gin Glu Phe

50 55 60

Asn Ala Gly Cys Val Ala Trp Asp Pro Thr Pro Val Glu His Glu Gin 65 70 75 80

Ala Val Gly Gly Cys Ser Ala Pro Ala Thr Leu Ile Pro Arg Ala Ala

85 90 95

Ala Lys His Leu Ala Ala Leu Thr Arg Val Gin Ala Glu Arg Ser Ser 100 105 110 Gly Tyr Trp Trp Val Asn Gly Asp Gly Ile Arg Thr Cys Leu Arg Leu 115 120 125

Val Asp Ser Val Ser Gly Ile Asp Glu Phe Cys Glu Glu Leu Ala Ile

130 135 140

Arg Ile Cys Tyr Tyr Pro Arg Ser Pro Gly Gly Phe Val Arg Phe Val 145 150 155 160

Thr Ser Ile Arg Asn Ala Leu Gly Leu Pro 165 170

(2) INFORMATION FOR SEQ ID NO:10E

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 215 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 108:

Met Ala Gly Ala Pro Pro Arg Leu Pro Pro Arg Asn Pro Ala Pro Pro 1 5 10 15 Glu Gin Arg Pro Ala Ala Ala Ala Arg Pro Leu Ala Ala His Arg Glu 20 25 30

Ala Ala Gly Val Tyr Asn Ala Val Arg Thr Trp Gly Pro Asp Ala Glu

35 40 45

Ala Glu Pro Asp Gin Met Glu Asn Thr Tyr Leu Leu Pro Glu Asp Asp 50 55 60

Ala Ala Met Pro Ala Gly Val Gly Leu Gly Ser Thr Pro Ala Ala Asp 65 70 75 80

Thr Thr Ala Ala Ala Trp Pro Ala Glu Ser His Ala Pro Arg Ala Pro 85 90 95 Ser Glu Glu Ala Asp Ser Ile Tyr Glu Ser Val Ser Glu Asp Gly Gly 100 105 110

Arg Val Tyr Glu Glu Ile Pro Trp Val Arg Val Tyr Glu Asn Ile Cys

115 120 125

Leu Arg Arg Gin Asp Ala Gly Gly Ala Ala Pro Pro Gly Asp Ala Pro 130 135 140

Asp Ser Pro Tyr Ile Glu Ala Glu Asn Pro Leu Tyr Asp Trp Gly Gly

145 150 155 160

Ser Ala Leu Phe Ser Pro Pro Gly Ala Thr Arg Ala Pro Asp Pro Gly

165 170 175 Leu Ser Leu Ser Pro Met Pro Ala Arg Pro Arg Thr Asn Ala Asn Asp

180 185 190

Gly Pro Thr Asn Val Ala Ala Leu Ser Ala Leu Leu Thr Lys Leu Lys

195 200 205

Arg Gly Arg His Gin Ser His 210 215

(2) INFORMATION FOR SEQ ID NO: 109:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 393 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 109:

Met Gin Arg Arg Arg Ala Ser Ser Leu Arg Leu Ala Arg Cys Leu Thr

1 5 10 15

Pro Ala Asn Leu Ile Arg Gly Ala Asn Ala Gly Val Pro Glu Arg Arg 20 25 30 Ile Phe Ala Gly Cys Leu Leu Pro Thr Pro Glu Gly Leu Leu Ser Ala 35 40 45

Ala Val Gly Val Leu Arg Gin Arg Ala Asp Asp Leu Gin Pro Ala Phe

50 55 60

Leu Thr Gly Ala Asp Arg Ser Val Arg Leu Ala Ala Arg His His Asn 65 70 75 80

Thr Val Pro Glu Ser Leu Ile Val Asp Gly Leu Ala Ser Asp Pro His

85 90 95

Tyr Asp Tyr Ile Arg His Tyr Ala Ser Ala Ala Lys Gin Ala Leu Gly 100 105 110 Glu Val Glu Leu Ser Gly Gly Gin Leu Ser Arg Ala Ile Leu Ala Gin 115 120 125

Tyr Trp Lys Tyr Leu Gin Thr Val Val Pro Ser Gly Leu Asp Ile Pro

130 135 140

Asp Asp Pro Ala Gly Xaa Cys Asp Pro Ser Leu His Val Leu Met Arg 145 150 155 160

Pro Thr Leu Leu Pro Lys Leu Val Val Arg Ala Pro Phe Lys Ser Gly

165 170 175

Ala Ala Ala Ala Lys Tyr Ala Ala Ala Val Ala Gly Leu Arg Asp Ala 180 185 190 Ala His Arg Leu Gin Gin Tyr Met Phe Phe Met Arg Pro Ala Asp Pro 195 200 205

Ser Arg Pro Ser Thr Asp Thr Ala Leu Arg Leu Ser Glu Leu Leu Ala

210 215 220

Tyr Val Ser Val Leu Tyr His Trp Ala Ser Trp Met Leu Trp Thr Ala 225 230 235 240

Asp Lys Tyr Val Cys Arg Arg Leu Gly Pro Ala Asp Arg Arg Phe Val

245 250 255

Ser Gly Ser Leu Glu Ala Pro Ala Glu Thr Phe Ala Arg His Leu Asp 260 265 270 Arg Gly Pro Ser Gly Thr Thr Gly Ser Met Gin Cys Met Ala Leu Arg 275 280 285

Ala Ala Val Ser Asp Val Leu Gly His Leu Thr Arg Leu Ala His Leu 290 295 300 Trp Glu Thr Gly Lys Arg Ser Gly Gly Thr Tyr Gly Ile Val Asp Ala 305 310 315 320

Ile Val Ser Thr Val Glu Val Leu Ser Ile Val His His His Ala Gin

325 330 335

Tyr Ile Ile Asn Ala Thr Leu Thr Gly Tyr Val Val Trp Ala Ser Asp

340 345 350

Ser Leu Asn Asn Glu Tyr Leu Arg Ala Ala Val Asp Ser Gin Glu Arg

355 360 365

Phe Cys Arg Thr Ala Ala Pro Leu Phe Pro Thr Met Thr Ala Pro Ser

370 375 380

Trp Ala Arg Met Glu Leu Ser Ile Lys 385 390

(2) INFORMATION FOR SEQ ID NO: 110:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 680 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 110:

Met Ser Val Arg Gly His Ala Val Arg Arg Arg Arg Ala Ser Thr Arg

1 5 10 15

Ser His Ala Pro Ser Ala His Arg Ala Glu Ser Pro Val Glu Asp Glu 20 25 30 Pro Glu Gly Gly Gly Val Gly Leu Met Gly Tyr Leu Arg Ala Val Phe 35 40 45

Asn Val Asp Asp Asp Ser Glu Val Glu Ala Ala Gly Glu Met Ala Ser

50 55 60

Glu Glu Pro Pro Pro Arg Arg Arg Arg Glu Arg His Pro Gly Ser Arg 65 70 75 80

Arg Ala Ser Glu Ala Arg Ala Ala Ala Pro Pro Arg Arg Ala Ser Phe

85 90 95

Pro Arg Pro Arg Ser Val Thr Ala Arg Ser Gin Ser Val Arg Gly Arg 100 105 110 Arg Asp Ser Ala Ile Thr Arg Ala Pro Arg Gly Gly Tyr Leu Gly Pro 115 120 125

Met Asp Pro Arg Asp Val Leu Gly Arg Val Gly Gly Ser Arg Val Val 130 135 140 Pro Ser Pro Leu Phe Leu Asp Glu Leu Ser Tyr Glu Glu Asp Asp Tyr

145 150 155 160

Pro Ala Ala Val Ala His Asp Asp Gly Ala Gly Ala Arg Pro Pro Ala

165 170 175 Thr Val Glu Ile Ile Glu Gly Arg Val Ser Gly Pro Glu Leu Gin Ala

180 185 190

Ala Phe Pro Leu Asp Arg Leu Thr Pro Arg Val Ala Ala Trp Asp Glu

195 200 205

Ser Val Arg Ser Ala Leu Gly His Pro Ala Gly Phe Tyr Pro Cys Pro 210 215 220

Asp Ser Ala Phe Gly Leu Ser Arg Val Gly Val Met His Phe Asp Ala

225 230 235 240

Asp Pro Lys Val Phe Phe Arg Gin Thr Leu Gin Gin Gly Glu Ala Trp

245 250 255 Tyr Val Thr Gly Asp Ala Ile Leu Asp Leu Thr Asp Arg Arg Ala Lys

260 265 270

Thr Ser Pro Ser Arg Ala Met Gly Phe Leu Val Asp Ala Ile Val Arg

275 280 285

Val Ala Ile Asn Gly Trp Val Cys Gly Thr Arg Leu His Thr Glu Gly 290 295 300

Arg Gly Ser Glu Leu Asp Asp Arg Ala Ala Glu Leu Arg Arg Gin Phe

305 310 315 320

Ala Ser Leu Thr Ala Leu Arg Pro Val Gly Ala Ala Ala Val Pro Leu

325 330 335 Leu Ser Ala Gly Gly Ala Ala Pro Pro His Pro Gly Pro Asp Ala Ala

340 345 350

Val Phe Arg Ser Ser Leu Gly Ser Leu Leu Tyr Trp Pro Gly Val Arg

355 360 365

Ala Leu Leu Gly Arg Asp Cys Arg Val Ala Ala Arg Tyr Ala Gly Arg 370 375 380

Met Thr Tyr Ile Ala Thr Gly Ala Leu Leu Ala Arg Phe Asn Pro Gly

385 390 395 400

Ala Val Lys Cys Val Leu Pro Arg Glu Ala Ala Phe Ala Gly Arg Val

405 410 415 Leu Asp Val Leu Ala Val Leu Ala Glu Gin Thr Val Gin Trp Leu Ser

420 425 430

Val Val Val Gly Ala Arg Leu His Pro His Ser Ala His Pro Ala Phe

435 440 445

Ala Asp Val Glu Gin Glu Ala Leu Phe Arg Ala Leu Pro Leu Gly Ser 450 455 460

Pro Gly Val Val Ala Ala Glu His Glu Ala Leu Gly Asp Thr Ala Ala 465 470 475 480

Arg Arg Leu Leu Ala Thr Ser Gin Ala Val Leu Gly Ala Ala Val Tyr 485 490 495

Ala Leu His Thr Ala Thr Val Thr Leu Lys Tyr Ala Cys Gly Asp Ala

500 _ 505 510

Arg Arg Arg Arg Asp Asn Ala Ala Ala Ala Arg Ala Val Leu Ala Thr 515 520 525

Gly Leu Ile Leu Gin Arg Leu Leu Gly Leu Ala Asp Thr Val Val Ala

530 535 540

Cys Val Ala Ala Phe Asp Gly Gly Ser Thr Ala Pro Glu Val Gly Thr 545 550 555 560 Tyr Thr Pro Leu Arg Tyr Ala Cys Val Leu Arg Ala Thr Gin Pro Leu

565 570 575

Tyr Ala Arg Thr Thr Pro Ala Lys Phe Trp Ala Asp Val Arg Ala Ala

580 585 590

Ala Glu His Val Asp Leu Arg Pro Ala Ser Ser Ala Pro Arg Ala Pro 595 600 605

Val Ser Gly Thr Ala Asp Pro Ala Phe Leu Leu Glu Asp Leu Ala Ala

610 615 620

Phe Pro Pro Ala Pro Leu Asn Ser Glu Ser Val Leu Gly Pro Arg Val 625 630 635 640 Arg Val Val Asp Ile Met Ala Gin Phe Arg Lys Leu Leu Met Gly Asp

645 650 655

Glu Glu Thr Ala Ala Leu Arg Ala His Val Ser Gly Arg Arg Ala Thr

660 665 670

Gly Leu Gly Gly Pro Pro Arg Pro 675 680

(2) INFORMATION FOR SEQ ID NO: 111:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 556 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 111:

Val Ile Leu Lys Met Arg Gly Gly Gly Arg Glu Met Ser Val Ile Gly 1 5 10 15

Asp Ala Arg His Pro Arg Gin Phe Pro Ser Gin Gly Pro Arg Pro Phe

20 25 30

Ser Val Ala Gly Pro Gly Ser Leu Pro Pro Ser Pro Pro Pro Gly Ala 35 40 45

Arg Ala Leu Leu Ile Arg Leu Ser Lys Ser Leu Ser Pro Asp Pro Thr

50 55 _. 60

Ala Pro Met Asp Leu Leu Val Asn Asn Leu Phe Ala Asp Ala Asp Gly 65 70 75 80

Val Ser Pro Pro Pro Pro Arg Pro Ala Gly Gly Pro Lys Asn Thr Pro

85 90 95

Ala Ala Pro Pro Leu Tyr Ala Thr Gly Arg Leu Ser Gin Ala Gin Leu 100 105 110 Met Pro Ser Pro Pro Met Pro Val Pro Pro Ala Ala Leu Phe Asn Arg 115 120 125

Leu Leu Asp Asp Leu Gly Phe Ser Ala Gly Pro Ala Leu Cys Thr Met

130 135 140

Leu Asp Thr Trp Asn Glu Asp Leu Phe Ser Gly Phe Pro Thr Asn Ala 145 150 155 160

Asp Met Tyr Arg Glu Cys Lys Phe Leu Ser Thr Leu Pro Ser Asp Val

165 170 175

Ile Asp Trp Gly Asp Ala His Val Pro Glu Arg Ser Pro Ile Asp Ile 180 185 190 Arg Ala His Gly Asp Val Ala Phe Pro Thr Leu Pro Ala Thr Arg Asp 195 200 205

Glu Leu Pro Ser Tyr Tyr Glu Ala Met Ala Gin Phe Phe Arg Gly Glu

210 215 220

Leu Arg Ala Arg Glu Glu Ser Tyr Arg Thr Val Leu Ala Asn Phe. Cys 225 230 235 240

Ser Ala Leu Tyr Arg Tyr Leu Arg Ala Ser Val Arg Gin Leu His Arg

245 250 255

Gin Ala His Met Arg Gly Arg Asn Arg Asp Leu Arg Glu Met Leu Arg 260 265 270 Thr Thr Ile Ala Asp Arg Tyr Tyr Arg Glu Thr Ala Arg Leu Ala Arg 275 280 285

Val Leu Phe Leu His Leu Tyr Leu Phe Leu Ser Arg Glu Ile Leu Trp

290 295 300

Ala Ala Tyr Ala Glu Gin Met Met Arg Pro Asp Leu Phe Asp Gly Leu 305 310 315 320

Cys Cys Asp Leu Glu Ser Trp Arg Gin Leu Ala Cys Leu Phe Gin Pro

325 330 335

Leu Met Phe Ile Asn Gly Ser Leu Thr Val Arg Gly Val Pro Val Glu 340 345 350 Ala Arg Arg Leu Arg Glu Leu Asn His Ile Arg Glu His Leu Asn Leu 355 360 365

Pro Leu Val Arg Ser Ala Ala Ala Glu Glu Pro Gly Ala Pro Leu Thr 370 375 380 Thr Pro Pro Val Leu Gin Gly Asn Gin Ala Arg Ser Ser Gly Tyr Phe 385 390 395 400

Met Leu Leu Ile Arg Ala Lys Leu Asp Ser Tyr Ser Ser Val Ala Thr 405 410 415 Ser Glu Gly Glu Ser Val Met Arg Glu His Ala Tyr Ser Arg Gly Arg 420 425 430

Thr Arg Asn Asn Tyr Gly Ser Thr Ile Glu Gly Leu Leu Asp Leu Pro

435 440 445

Asp Asp Asp Asp Ala Pro Ala Glu Ala Gly Leu Val Ala Pro Arg Met 450 455 460

Ser Phe Leu Ser Ala Gly Gin Arg Pro Arg Arg Leu Ser Thr Thr Ala 465 470 475 480

Pro Ile Thr Asp Val Ser Leu Gly Asp Glu Leu Arg Leu Asp Gly Glu 485 490 495 Glu Val Asp Met Thr Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Glu 500 505 510

Met Leu Gly Asp Val Glu Ser Pro Ser Pro Gly Met Thr His Asp Pro

515 520 525

Val Leu Tyr Gly Ala Leu Asp Val Asp Asp Phe Glu Phe Glu Gin Met 530 535 540

Phe Thr Asp Ala Met Gly Ile Asp Asp Phe Gly Gly 545 550 555

(2) INFORMATION FOR SEQ ID NO: 112:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7362 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 112:

CGCGGGGGAG GGGACGACGC GGGGGAGGGG ACGACGCGGG GGAGGGGAGG ACGCGGGGGA 60

TATATAAAGC GGTACAAAGC GCGGGAATGG GCATATTGGA CCCGCGTGAT TCGGTTGCTC 120

GCGGTTGTCT TGTTTGGACG TTTTTTATGC GGGAACAAGG GGGCTTACCG GTTACACTGT 180

CCGCTCGCTA TGGGGTTCGT CTGTCTGTTT GGGCTTGTCG TTATGGGAGC CTGGGGGGCG 240

TGGGGTGGGT CACAGGCAAC CGAATATGTT CTTCGTAGTG TTATTGCCAA AGAGGTGGGG 300 GACATACTAA GAGTGCCTTG CATGCGGACC CCCGCGGACG ATGTTTCTTG GCGCTACGAG 360

GCCCCGTCCG TTATTGACTA TGCCCGCATA GACGGAATAT TTCTTCGCTA TCACTGCCCG 420

GGGTTGGACA CGTTTTTGTG GGATAGGCAC GCCCAGAGGG CGTATCTGGT TAACCCCTTT 480

CTCTTTGCGG CGGGATTTTT GGAGGACTTG AGTCACTCTG TGTTTCCGGC CGACACCCAG 540 GAAACAACGA CGCGCCGGGC CCTTTATAAA GAGATACGCG ATGCGTTGGG CAGTCGAAAA 600

CAGGCCGTCA GCCACGCACC CGTCAGGGCC GGGTGTGTAA ACTTTGACTA CTCACGCACT 660

CGCCGCTGCG TCGGGCGACG CGATTTACGG CCTGCCAACA CCACGTCAAC GTGGGAACCG 720

CCTGTGTCGT CGGACGATGA AGCGAGCTCG CAGTCGAAGC CCCTCGCCAC CCAGCCGCCC 780 GTCCTCGCCC TTTCGAACGC CCCCCCACGG CGGGTCTCCC CGACGCGAGG TCGGCGCCGG 840

CATACTCGCC TCCGACGCAA CTAGCCACGT CTGCATCGCA AGCCACCCTG GGTCGGGAGC 900

AGGATATCCG ACCCGTCTAG CGGCCGGGTC GGCTGTCCAG CGTCGTCGCC CTAGAGGCTG 960

TCCGCCGGGC GTGATGTTTT CCGCATCTAC GACCCCCGAA CAGCCCCTGG GGCTGTCGGG 1020

CGATGCGACG CCGCCCCTGC CGACTTCCGT GCCCCTGGAC TGGGCCGCGT TTCGGCGCGC 1080 GTTTCTGATC GACGACGCCT GGCGGCCCCT GTTGGAGCCG GAGCTCGCGA ACCCCCTAAC 1140

CGCGCGCCTC CTCGCGGAGT ATGACCGTCG GTGCCAGACC GAAGAGGTGC TGCCGCCGCG 1200

GGAGGATGTG TTCTCCTGGA CGCGGTATTG TACCCCCGAC GACGTGCGCG TGGTTATCAT 1260

CGGGCAGGAC CCGTACCACC ATCCCGGCCA GGCGCACGGC CTGGCGTTTA GCGTGCGTGC 1320

GGATGTGCCG GTGCCTCCGA GTCTACGGAA CGTGCTGGCG GCGGTAAAAA ATTGTTACCC 1380 CGACGCGCGC ATGAGCGGCC GCGGCTGCCT GGAAAAGTGG GCTCGCGACG GCGTGCTGTT 1440

GTTGAACACG ACCCTGACCG TCAAGCGCGG GGCGGCGGCG TCCCACTCCA AGCTTGGATG 1500

GGACCGCTTT GTGGGCGGGG TGGTCCGACG GCTGGCCGCG CGCCGCCCGG GCCTGGTCTT 1560

TATGCTCTGG GGCGCCCATG CCCAGAACGC GATCAGGCCC GACCCTCGCC AACACTACGT 1620

CCTCAAGTTT TCTCACCCGT CGCCCCTCTC CAAGGTCCCG TTTGGGACGT GCCAGCATTT 1680 CCTCGCCGCG AATCGCTACC TCGAAACCCG GGACATTATG CCTATCGACT GGTCGGTATA 1740

AGATGCCGAC ATCCGGGGTC TTGATTTACG AGGGGGCAAT TAATAAAGAC TGTTGATGGT 1800

TAAATCTCGG GTCTCATACC GGTCCGTGAT GTCGGGCGTG GGGGAAGAGA GGGTCCCCTC 1860

TGCGTTTACT ATCCTTGCCT CGTGGGGCTG GACGTTTGCA CCCCAGAACC ATGATCCTGG 1920

CGCGTCGCCG AATACGACGC CCATAGAGTC GATTGCGGGG ACCGCACCGG ACGCGCACGT 1980 GGGGCCTCTC GACGGAGAGC CGGACCGGGA TGCGATCTCC CCGCTTACGT CGAGCGTGGC 2040

CGGCGACCCG CCGGGGGCGG ACGGCCCCTA CGTCACCTTT GATACTCTGT TTATGGTATC 2100

TTCGATCGAC GAACTGGGGC GCCGCCAGCT CACGGATACG ATCCGTAAGG ACCTGCGGCT 2160

GTCGCTGGCC AAGTTCAGCA TCGCGTGTAC CAAGACCTCG TCGTTTTCGG GGACGGCCGC 2220

GCGCCAGCGC AAGCGCGGAG CACCGCCGCA ACGCACATGC GTACCACGCA GCAACAAGAG 2280 CCTCCAGATG TTCGTTTTGT GCAAGCGCGC CAACGCCGCG CAGGTGCGCG AGCAGCTGCG 2340

GGCGGTTATT CGGTCGCGCA AGCCGCGCAA GTATTACACG CGGTCCTCGG ATGGGCGGCT 2400

CTGCCCGGCC GTCCCCGTGT TTGTACACGA GTTTGTTTCG TCCGAACCCA TGCGCCTCCA 2460

TCGAGATAAC GTCATGCTGT CTACGGAACC AGACTAAGCA CCCCCGCCGT CCCCTTTCTT 2520

TTCCCCCTAC CCTTCCCCCC GTTACTGATG TGTTGTGACG TTTCAATAAA TAACACGTAG 2580 CTTATTTTGT TGGATGATGG ATTGATTGAT TTTATTGACC GTTCGTTCGC CCGGCGGTGC 2640

CGTCGCCGCG CGCAGAGGGA ATATGCAAGC GGGCGGGGTG GGGAGGAAAG AAGGTTTCAG 2700

GTTCCGGGGG TTGGGTCTGC GTCGTCCAGG GTGGGGCTGA TCTGAATTTC CCGCAGAACC 2760

TCGACCAGTA GGTCTGTTGT GTTTGCTGGG AACTCGCCCG CCGTTGGGGA TACGGGGGCG 2820

GGGGGTGTGG TTGGGCGGAC GTCCAGGGGT GCGTTATCGC ACCCCCGCGC CGCCTCGGGG 2880 GCCGTCCCGT AGATCGTTGC GGTGATGTAG ATGGTGTCCG GGGTCCACAC CACCGTCAGG 2940

ATGCCGGCCG TCGCACTCCG GACGCTTTCG CCGTGCGATG AGCTGACCCA GGAGTCAAAG 3000

GGGTACGCGT ACATATGGGC GTCCCACCAG CGCTCCAGCC TCTGGGTACT AGCGCGTCCT 3060

ATAAAGCGGT ATGCGCAAAA TTCGGCACGA CAGTCGATAA TCACCAGCAG CCCGATGGGG 3120 GTGTGTTGTA TCACCACGCC TCCGCGGGGC AGGCGGTCCT GGCGCGCTCG ACCCCGCGTC 3180

AGAACCGCGC GCGTCCCTGA CTCAAACACG TGCACCACCT GTGCCGCGTC CGGCAGCGCG 3240

CTCGTTAGCG ACGCCCTGGG GTGATGTAGG CTGTACGCGA TGGTCGTCTG GGGGTTCCCC 3300

ATGTCTCGGG GGGGTGGGGG TGAATGTCAC CCGGCCCGGG TGCGGTGGGA ACGCGAGGGA 3360 ATGGAGGGTT AATAGACAAT GACCACATTC GGATCGCGTA GAGCAGATAG TATGTGCTCG 3420

CTAATGACGT CATCGCGTTC GTGGCGCTCC CGGAGCGGGT TTAGATTCAT GTGCAGGAAC 3480

TCGGATGAGG TGGTGCGGGA CATGGCTACG TACGCGCTGT TTAGGCGCAG GTTTCCGGGC 3540

GTGAAGCATA TGGCGACCTT GTCCAGACTG AGCCCCTGGG AGCGCGTGAT GGTCATCGCG 3600

AGTTTGGAGC TGATGCCGTA GTCGGCGTTG ATGGCCATGG CCAGCTCCGT GGAGTCGATC 3660 GACTCGACAA ACTCACTGAT GTTGGTATTG ACGACAGACA TGAAGCCGTG CTGGTCCCGC 3720

AGGACGATGT AGGGCAGGGG GGACTCCTCC AAGAACTCGG CCACGCCGGC CGTCGCGTGC 3780

CGCCGCCGCA GCTCCTCCGC GAACGCGAAC ACCCGGGTGT ACGTGTACCC CATCAGCGTG 3840

TAGTTGTCCG TCTGCAGGGC CACGGACATC AGCCCCCCGC GCGGCGAGCC GGTCAGCAGC 3900

TCGCAGCCCC GGAAGATGAC ATTGTCCACG TAGGTGCTGA AGGGGGCGCT CTCAAACACC 3960 TCCCCGAAGA GCTCCCGTAG GATAAGGTAT CGCCCCAGAA AGGCCCTCTT CAGGAGCCCA 4020

AACTGGGCGT GGACGGCCGC GGTGGTCTCC GGCTCTTCGA GGGCGTAGTG GCAGTAGAAC 4080

ACGTCCAGCT GCTGTTCGTC CAGCCCGGCG AAGATAACGT CAAGGTCGTC GTCGGGGAAG 4140

TCGTCCGGGC CCCCGTCCCG CGGGCCCAGG TGCTTAAAAT TGAACGCACG CTCCCCCGGA 4200

GAGCGGTCGC TGGTGTCGGC GGCCCTGGTT GCCGATGCGC CGGCGGCGTC CCGGCGTAGC 4260 GACAGGAGTT CTGCCGTCAG CTCCCCTAGG CGGCCGTAGG CCAGGGTCCT CTGGGTCGCG 4320

TCCAGGCCGG GGCGCTGGAG AAAGTTGTAA AAGTGAATCA GCCCGCCGAA CATGAGCCGC 4380

GACAGGAACC GGTAGGCGAA CTCCACCGAG GTCTCCCCCT GGGTCTTCAC GAAGCTGTCG 4440

TCGCGCAGCA CAGCCTCGAA GGTCCGAAAC GTCCCGTCGA ACCCAAACAC CATCTTTCGG 4500

AGGCGCGCGG TCACCGCGAC CTGGCTGTTG AGGACGTACG TGATGTCGTT CCGGGCCACG 4560 ACTAGCTGTT GCTTGCTGTG CACCTCACAG CGCACGTGCC CCGCGTCCTG GTCCTGACTC 4620

TGGGAGTAGT TGGTGATGCG ACTGGCGTTG GCCGTGATCC ACTTTTCCAT GGTCAGCGTG 4680

GGTTGCTGCG TGAGCCGTCG ATACTCGTCA AACTCTTTGA CCGACACAAA CGTAAGCACG 4740

GGGAGGGTAA ACACAACAAA CTCCCCCTCG CGAGTCACCT TTAGGTAGGC GTGGAGCTTG 4800

GCCATGTACG CGCTGACCTC CTTGTGGGAC GAGAACAGCC GCGTCCACCC CGGAAGGTTG 4860 GCCGGGTTGG TGATGTAACT TTCCGGGACG ACAAAGCGGT CCACAAACTG CATGTGCTCC 4920

TCGGTGATGG GAAGGCCGTA CTCCAGCACC TTCATGAGGT TCCCGAACTC GTGCTCCACA 4980

CATCGCTTGT TGTTAATGAA AATGGCCCAG CTGTGCGAGA GGCGCGTGTA CTCGCGTAGG 5040

GTGCGGTTGC AGATGAGGTA CGTGAGCACG TTTTCGCTCT GCCGGACGGA GCATCGCAGT 5100

TTTTGGTGTT CGAAGGTGGA CTCCAGCGAG GCCGTCTGGG TCGGCGACCC CACGCACACC 5160 AGCACCGGCC GCAGGCGGCC CGCGTACTGG GGGGTGTGGT ACAGGGCGTT AATCATCCAC 5220

CAGCAATACA CCACGGTCGT GAGTAGGTGC CGCCCCAGGA GCCCGGCCTC GTCGATGACG 5280

ATAATGTTGC TGCGGGTGAA AGCCGGCAGC GCCCCGTGTG TGACCGAGGC CAGGCGCGTG 5340

AGGGCACCCT GGCCCAGCCC CAAAGTCTGC TCTAGGGCGG TGAGGGCGTG GAACTCGTTT 5400

CGCGCGTCTT CGCCCCCGTG CGCCGCCAGG GCCCGCTTGG TGATGTCGAG GATCACCTCC 5460 CAGTAGTACG TCAGGTCTCG CCGCTGCAGG TCTTCCAGCG AGGCGGGGCT GCTGGCCAGG 5520

GTGTACGGGT GCTGCCCCAG CTGGGCCTGG ACGTGATTCC CGCGAAACCC GAACTCGTGA 5580

AAGATGGTGT TGATGGGTCG ACTCAGAAAC GCCCCCGAGA GCTTAACGTA CATGTTCTGC 5640

GCCGCGATTC GCGTGGCGCC CGTGACCACG CAGTCCAGGA CCTCGTTGAG GGTCTGCACG 5700 CACGTACTCT TTCCGGATCC GGCGTTGCCG GTGATGAGAT ACGCCGCGAA CGGAAACTCC 5760

CGGAGCGGCA GGCCGGTCGG GACCTCCAAG GCCGCCACGT CCCGGAACCA CTGCAGGCGC 5820

GGCACCTGCG TGACGTCGAG CTGCTGCTGC GAGAGCTCTC GGATGCGTGC GATGATTGGT 5880

TGGACCCCGT GCATGGACGT AAAATTTAAA AACGCCTCGT CCCTGAACCG CACGGCGGGT 5940 CTGGCCCCGG GCTGCTGTGG GGGCGGACCT GGTGCCCGGA CGTCCCGCGA GCCCTCCCCG 6000

CCGGACGCCG CCATGGCCGC ACAGCGCGCG CGGGCGCCGG CGATGCGGAC GCGGGGCGGC 6060

GACGCGGCGC TATGCGCCCC CGAGGACGGC TGGGTGAAGG TTCACCCCAC CCCCGGGACG 6120

ATGTTGTTCC GCGAGATTCT CCTCGGGCAG ATGGGGTACA CCGAGGGTCA GGGGGTGTAC 6180

AACGTCGTCC GGTCCAGCGA GGCCGCCACC CGACAGCTGC AGGCGGCGAT CTTCCACGCG 6240 CTCCTCAACG CCACAACGTA CCGGGACCTG GAGGAGGACT GGCGCCGCCA CGTGGTGGCC 6300

CGCGGCCTCC AGCCGCAGCG GCTGGTTCGC AGGTACCGGA ACGCCCGGGA GGGCGATATC 6360

GCCGGGGTGG CCGAGCGGGT GTTCGACACG TGGCGATGCA CGCTCAGGAC GACGCTGCTG 6420

GACTTTGCCC ACGGGGTGGT AGACTGCTTT GCGCCGGGCG GCCCAAGCGG ACCGACCAGC 6480

TTCCCCAAAT ATATCGACTG GCTGACGTGT CTGGGGCTGG TTCCCATATT GCGCAAGACG 6540 CGCGAGGGGG AGGCGACGCA GCGCCTGGGG GCGTTTCTCA GGCAGCACAC GCTGCCCCGG 6600

CAGCTGGCCA CGGTCGCCGG GGCCGCGGAG CGCGCCGGCC CGGGGCTTCT GGAGCTGGCC 6660

GTCGCGTTCG ACTCCACGCG CATGGCGGAA TACGACCGTG TGCACATCTA CTACAACCAT 6720

CGCCGGGGGG AGTGGCTGGT GCGCGACCCG GTCAGCGGGC AGCGCGGCGA GTGCCTGGTG 6780

CTGTGCCCCC CCCTGTGGAC CGGCGACCGC CTGGTCTTCG ATTCGCCCGT TCAGCGGCTG 6840 TGCCCCGAGA TCGTCGCGTG CCACGCCCTC CGGGAACACG CGCACATCTG CCGTCTGCGC 6900

AACACCGCGT CCGTCAAGGT GCTGTTGGGG CGCAAGAGCG ACAGCGAGCG CGGGGTGGCT 6960

GGCGCCGCGC GGGTCGTCAA TAAGGCGCTG GGGGAGGATG ACGAGACGAA GGCCGGCTCG 7020

GCCGCCTCGC GTCTCGTGCG GCTCATCATC AACATGAAGG GCATGCGCCA CGTGGGCGAC 7080

ATCAACGACA CGGTACGCGC CTACTTGGAC GAGGCGGGGG GGCACCTGAT CGACACCCCC 7140 GCCGTCGACC ACACCCTCCC TGGGTTCGGC AAGGGCGGCA CCGGCCGCGG GTCGGCGGCC 7200

CAGGACCCGG GGGCGCGACC GCAGCAGCTT CGCCAGGCGT TTCAGACGGC CGTGGTCAAC 7260

AACATCAACG GCATGCTGGA GGGCTATATC AATAATCTCT TTGGAACCAT AGAACGCCTG 7320

CGAGAGACGA ACGCGGGTCT GGCGACCCAG CTGCAGGCGC G 7362

(2) INFORMATION FOR SEQ ID NO: 113:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 180 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 113:

Met Arg Thr Pro Ala Asp Asp Val Ser Trp Arg Tyr Glu Ala Pro Ser 1 5 10 15 Val Ile Asp Tyr Ala Arg Ile Asp Gly Ile Phe Leu Arg Tyr His Cys

20 25 30

Pro Gly Leu Asp Thr Phe Leu Trp Asp Arg His Ala Gin Arg Ala Tyr 35 40 45 Leu Val Asn Pro Phe Leu Phe Ala Ala Gly Phe Leu Glu Asp Leu Ser 50 55 60

His Ser Val Phe Pro Ala Asp Thr Gin Glu Thr Thr Thr Arg Arg Ala 65 70 75 80

Leu Tyr Lys Glu Ile Arg Asp Ala Leu Gly Ser Arg Lys Gin Ala Val 85 90 95

Ser His Ala Pro Val Arg Ala Gly Cys Val Asn Phe Asp Tyr Ser Arg 100 105 110

Thr Arg Arg Cys Val Gly Arg Arg Asp Leu Arg Pro Ala Asn Thr Thr 115 120 125 Ser Thr Trp Glu Pro Pro Val Ser Ser Asp Asp Glu Ala Ser Ser Gin 130 135 140

Ser Lys Pro Leu Ala Thr Gin Pro Pro Val Leu Ala Leu Ser Asn Ala 145 150 155 160

Pro Pro Arg Arg Val Ser Pro Thr Arg Gly Arg Arg Arg His Thr Arg 165 170 175

Leu Arg Arg Asn 180

(2) INFORMATION FOR SEQ ID NO: 114:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 334 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 114:

Met Lys Arg Ala Arg Ser Arg Ser Pro Ser Pro Pro Ser Arg Pro Ser

1 5 10 15

Ser Pro Phe Arg Thr Pro Pro His Gly Gly Ser Pro Arg Arg Glu Val 20 25 30 Gly Ala Gly Ile Leu Ala Ser Asp Ala Thr Ser His Val Cys Ile Ala 35 40 45

Ser His Pro Gly Ser Gly Ala Gly Tyr Pro Thr Arg Leu Ala Ala Gly 50 55 60 Ser Ala Val Gin Arg Arg Arg Pro Arg Gly Cys Pro Pro Gly Val Met

65 70 75 80

Phe Ser Ala Ser Thr Thr Pro Glu Gin Pro Leu Gly Leu Ser Gly Asp

85 90 95 Ala Thr Pro Pro Leu Pro Thr Ser Val Pro Leu Asp Trp Ala Ala Phe 100 105 110

Arg Arg Ala Phe Leu Ile Asp Asp Ala Trp Arg Pro Leu Leu Glu Pro 115 120 125 Glu Leu Ala Asn Pro Leu Thr Ala Arg Leu Leu Ala Glu Tyr Asp Arg 130 135 140

Arg Cys Gin Thr Glu Glu Val Leu Pro Pro Arg Glu Asp Val Phe Ser

145 150 155 160

Trp Thr Arg Tyr Cys Thr Pro Asp Asp Val Arg Val Val Ile Ile Gly 165 170 175 Gin Asp Pro Tyr His His Pro Gly Gin Ala His Gly Leu Ala Phe Ser 180 185 190

Val Arg Ala Asp Val Pro Val Pro Pro Ser Leu Arg Asn Val Leu Ala 195 200 205 Ala Val Lys Asn Cys Tyr Pro Asp Ala Arg Met Ser Gly Arg Gly Cys 210 215 220

Leu Glu Lys Trp Ala Arg Asp Gly Val Leu Leu Leu Asn Thr Thr Leu

225 230 235 240

Thr Val Lys Arg Gly Ala Ala Ala Ser His Ser Lys Leu Gly Trp Asp 245 250 255 Arg Phe Val Gly Gly Val Val Arg Arg Leu Ala Ala Arg Arg Pro Gly 260 265 270

Leu Val Phe Met Leu Trp Gly Ala His Ala Gin Asn Ala Ile Arg Pro 275 280 285 Asp Pro Arg Gin His Tyr Val Leu Lys Phe Ser His Pro Ser Pro Leu 290 295 300

Ser Lys Val Pro Phe Gly Thr Cys Gin His Phe Leu Ala Ala Asn Arg

305 310 315 320

Tyr Leu Glu Thr Arg Asp Ile Met Pro Ile Asp Trp Ser Val 325 330

(2) INFORMATION FOR SEQ ID NO: 115:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 231 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 115:

Met Val Lys Ser Arg Val Ser Tyr Arg Ser Val Met Ser Gly Val Gly 1 5 10 15

Glu Glu Arg Val Pro Ser Ala Phe Thr Ile Leu Ala Ser Trp Gly Trp

20 25 30

Thr Phe Ala Pro Gin Asn His Asp Pro Gly Asp Asn Thr Thr Pro Ile 35 40 45

Glu Ser Ile Ala Gly Thr Ala Pro Asp Ala His Val Gly Pro Leu Asp

50 55 60

Gly Glu Pro Asp Arg Asp Ala Ile Ser Pro Leu Thr Ser Ser Val Ala 65 70 75 80 Gly Asp Pro Pro Gly Ala Asp Gly Pro Tyr Val Thr Phe Asp Thr Leu

85 90 95

Phe Met Val Ser Ser Ile Asp Glu Leu Gly Arg Arg Gin Leu Thr Asp

100 105 110

Thr lie Arg Lys Asp Leu Arg Leu Ser Leu Ala Lys Phe Ser Ile Ala 115 120 125

Cys Thr Lys Thr Ser Ser Phe Ser Gly Thr Ala Ala Arg Gin Arg Lys

130 135 140

Arg Gly Ala Pro Pro Gin Arg Thr Cys Val Pro Arg Ser Asn Lys Ser 145 150 155 160 Leu Gin Met Phe Val Leu Cys Lys Arg Ala Asn Ala Ala Gin Val Arg

165 170 175

Glu Gin Leu Arg Ala Val Ile Arg Ser Arg Lys Pro Arg Lys Tyr Tyr

180 185 190

Thr Arg Ser Ser Asp Gly Arg Leu Cys Pro Ala Val Pro Val Phe Val 195 200 205

His Glu Phe Val Ser Ser Glu Pro Met Arg Leu His Arg Asp Asn Val

210 215 220

Met Leu Ser Thr Glu Pro Asp 225 230

(2) INFORMATION FOR SEQ ID NO: 116:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 199 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 116:

Met Gly Asn Pro Gin Thr Thr Ile Ala Tyr Ser Leu His His Pro Arg 1 5 10 15

Ala Ser Leu Thr Ser Ala Leu Pro Asp Ala Ala Gin Val Val His Val

20 25 30

Phe Glu Ser Gly Thr Arg Ala Val Leu Thr Arg Gly Arg Ala Arg Gin 35 40 45

Asp Arg Leu Pro Arg Gly Gly Val Val Ile Gin His Thr Pro Ile Gly

50 55 60

Leu Leu Val Ile Ile Asp Cys Arg Ala Glu Phe Cys Ala Tyr Arg Phe 65 70 75 80 Ile Gly Arg Ala Ser Thr Gin Arg Leu Glu Arg Trp Trp Asp Ala His

85 90 95

Met Tyr Ala Tyr Pro Phe Asp Ser Trp Val Ser Ser Ser His Gly Glu

100 105 110

Ser Val Arg Ser Ala Thr Ala Gly Ile Leu Thr Val Val Trp Thr Pro 115 120 125

Asp Thr Ile Tyr Ile Thr Ala Thr Ile Tyr Gly Thr Ala Pro Glu Ala

130 135 140

Arg Cys Asp Asn Ala Pro Leu Asp Val Arg Pro Thr Thr Pro Pro Ala 145 150 155 160 Pro Val Ser Pro Thr Ala Gly Glu Phe Pro Ala Asn Thr Thr Asp Leu

165 170 175

Leu Val Glu Val Leu Arg Glu Ile Gin Ile Ser Pro Thr Leu Asp Asp

180 185 190

Ala Asp Pro Thr Pro Gly Thr 195

(2) INFORMATION FOR SEQ ID NO: 117:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 877 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 117: Met Ala Ala Ser Gly Gly Glu Gly Ser Arg Asp Val Arg Ala Pro Gly

1 5 10 15

Pro Pro Pro Gin Gin Pro Gly Ala Arg Pro Ala Val Arg Phe Arg Asp 20 25 30 Glu Ala Phe Leu Asn Phe Thr Ser Met His Gly Val Gin Pro Ile Ile 35 40 45

Ala Arg Ile Arg Glu Leu Ser Gin Gin Gin Leu Asp Val Thr Gin Val

50 55 60

Pro Arg Leu Gin Trp Phe Arg Asp Val Ala Ala Leu Glu Val Pro Thr 65 70 75 80

Gly Leu Pro Leu Arg Glu Phe Pro Phe Ala Ala Tyr Leu Ile Thr Gly

85 90 95

Asn Ala Gly Ser Gly Lys Ser Thr Cys Val Gin Thr Leu Asn Glu Val 100 105 110 Leu Asp Cys Val Val Thr Gly Ala Thr Arg Ile Ala Ala Gin Asn Met 115 120 125

Tyr Val Lys Leu Ser Gly Ala Phe Leu Ser Arg Pro Ile Asn Thr Ile

130 135 140

Phe His Glu Phe Gly Phe Arg Gly Asn His Val Gin Ala Gin Leu Gly 145 150 155 160

Gin His Pro Tyr Thr Leu Ala Ser Ser Pro Ala Ser Leu Glu Asp Leu

165 170 175

Gin Arg Arg Asp Leu Thr Tyr Tyr Trp Glu Val Ile Leu Asp Ile Thr 180 185 190 Lys Arg Ala Ala His Gly Gly Glu Asp Ala Arg Asn Glu Phe His Ala 195 200 205

Leu Thr Ala Leu Glu Gin Thr Leu Gly Leu Gly Gin Gly Ala Leu Thr

210 215 220

Arg Leu Ala Ser Val Thr His Gly Ala Leu Pro Ala Phe Thr Arg Ser 225 230 235 240

Asn Ile Ile Val Ile Asp Glu Ala Gly Leu Leu Gly Arg His Leu Leu

245 250 255

Thr Thr Val Val Tyr Cys Trp Trp Met Ile Asn Ala Leu Tyr His Thr 260 265 270 Pro Gin Tyr Ala Gly Arg Leu Arg Pro Val Leu Val Cys Val Gly Ser 275 280 285

Pro Thr Gin Thr Ala Ser Leu Glu Ser Thr Phe Glu His Gin Lys Leu

290 295 300

Arg Cys Ser Val Arg Gin Ser Glu Asn Val Leu Thr Tyr Leu Ile Cys 305 310 315 320

Asn Arg Thr Leu Arg Glu Tyr Thr Arg Leu Ser His Ser Trp Ala Ile

325 330 335

Phe lie Asn Asn Lys Arg Cys Val Glu His Glu Phe Gly Asn Leu Met 340 345 350

Lys Val Leu Glu Tyr Gly Leu Pro Ile Thr Glu Glu His Met Gin Phe

355 360 365

Val Asp Arg Phe Val Val Pro Glu Ser Tyr Ile Thr Asn Pro Ala Asn 370 375 380

Leu Pro Gly Trp Thr Arg Leu Phe Ser Ser His Lys Glu Val Ser Ala

385 390 395 400

Tyr Met Ala Lys Leu His Ala Tyr Leu Lys Val Thr Arg Glu Gly Glu

405 410 415 Phe Val Val Phe Thr Leu Pro Val Leu Thr Phe Val Ser Val Lys Glu

420 425 430

Phe Asp Glu Tyr Arg Arg Leu Thr Gin Gin Pro Thr Leu Thr Met Glu

435 440 445

Lys Trp Ile Thr Ala Asn Ala Ser Arg Ile Thr Asn Tyr Ser Gin Ser 450 455 460

Gin Asp Gin Asp Ala Gly His Val Arg Cys Glu Val His Ser Lys Gin

465 470 475 480

Gin Leu Val Val Ala Arg Asn Asp Ile Thr Tyr Val Leu Asn Ser Gin

485 490 495 Val Ala Val Thr Ala Arg Leu Arg Lys Met Val Phe Gly Phe Asp Gly

500 505 510

Thr Phe Arg Thr Phe Glu Ala Val Leu Arg Asp Asp Ser Phe Val Lys

515 520 525

Thr Gin Gly Glu Thr Ser Val Glu Phe Ala Tyr Arg Phe Leu Ser Arg 530 535 540

Leu Met Phe Gly Gly Leu Ile His Phe Tyr Asn Phe Leu Gin Arg Pro

545 550 555 560

Gly Leu Asp Ala Thr Gin Arg Thr Leu Ala Tyr Gly Arg Leu Gly Glu

565 570 575 Leu Thr Ala Glu Leu Leu Ser Leu Arg Arg Asp Ala Ala Gly Ala Ser

580 585 590

Ala Thr Arg Ala Ala Asp Thr Ser Asp Arg Ser Pro Gly Glu Arg Ala

595 600 605

Phe Asn Phe Lys His Leu Gly Pro Arg Asp Gly Gly Pro Asp Asp Phe 610 615 620

Pro Asp Asp Asp Leu Asp Val Ile Phe Ala Gly Leu Asp Glu Gin Gin 625 630 635 640

Leu Asp Val Phe Tyr Cys His Tyr Ala Leu Glu Glu Pro Glu Thr Thr 645 650 655 Ala Ala Val His Ala Gin Phe Gly Leu Leu Lys Arg Ala Phe Leu Gly 660 665 670

Arg Tyr Leu Ile Leu Arg Glu Leu Phe Gly Glu Val Phe Glu Ser Ala 675 680 685 Pro Phe Ser Thr Tyr Val Asp Asn Val Ile Phe Arg Gly Cys Glu Leu

690 695 700

Leu Thr Gly Ser Pro Arg Gly Gly Leu Met Ser Val Gin Thr Asp Asn 705 710 715 720 Tyr Thr Leu Met Gly Tyr Thr Tyr Thr Arg Val Phe Ala Phe Ala Glu

725 730 735

Glu Leu Arg Arg Arg His Ala Thr Ala Gly Val Ala Glu Phe Leu Glu

740 745 750

Glu Ser Pro Leu Pro Tyr Ile Val Leu Arg Asp Gin His Gly Phe Met 755 760 765

Ser Val Val Asn Thr Asn Ile Ser Glu Phe Val Glu Ser Ile Asp Ser

770 775 780

Thr Glu Leu Ala Met Ala Ile Asn Ala Asp Tyr Gly Ile Ser Ser Lys 785 790 795 800 Leu Ala Met Thr Ile Thr Arg Ser Gin Gly Leu Ser Leu Asp Lys Val

805 810 815

Ala Ile Cys Phe Thr Pro Gly Asn Leu Arg Leu Asn Ser Ala Tyr Val

820 825 830

Ala Met Ser Arg Thr Thr Ser Ser Glu Phe Leu His Met Asn Leu Asn 835 840 845

Pro Leu Arg Glu Arg His Glu Arg Asp Asp Val Ile Ser Glu His Ile

850 855 860

Leu Ser Ala Leu Arg Asp Pro Asn Val Val Ile Val Tyr 865 870 875

(2) INFORMATION FOR SEQ ID NO: 118:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 588 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: H i

Met Val Leu Met Gly Arg Leu Arg Asn Ala Pro Glu Ser Leu Thr Tyr 1 5 10 , 15 Met Phe Cys Ala Ala Ile Arg Val Ala Pro Val Thr Thr Gin Ser Arg 20 25 30

Thr Ser Leu Arg Val Cys Thr His Val Leu Phe Pro Asp Pro Ala Leu 35 40 45 Pro Val Met Arg Tyr Ala Ala Asn Gly Asn Ser Arg Ser Gly Arg Pro

50 55 60

Val Gly Thr Ser Lys Ala Ala Thr Ser Arg Asn His Cys Arg Arg Gly 65 70 75 80 Thr Cys Val Thr Ser Ser Cys Cys Cys Glu Ser Ser Arg Met Arg Ala

85 90 95

Met lie Gly Trp Thr Pro Cys Met Asp Val Lys Phe Lys Asn Ala Ser

100 105 110

Ser Leu Asn Arg Thr Ala Gly Leu Ala Pro Gly Cys Cys Gly Gly Gly 115 120 125

Pro Gly Ala Arg Thr Ser Arg Glu Pro Ser Pro Pro Asp Ala Ala Met

130 135 140

Ala Ala Gin Arg Ala Arg Ala Pro Ala Met Arg Thr Arg Gly Gly Asp 145 150 155 160 Ala Ala Leu Cys Ala Pro Glu Asp Gly Trp Val Lys Val His Pro Thr

165 170 175

Pro Gly Thr Met Leu Phe Arg Glu Ile Leu Leu Gly Gin Met Gly Tyr

180 185 190

Thr Glu Gly Gin Gly Val Tyr Asn Val Val Arg Ser Ser Glu Ala Ala 195 200 205

Thr Arg Gin Leu Gin Ala Ala Ile Phe His Ala Leu Leu Asn Ala Thr

210 215 220

Tyr Asp Leu Glu Glu Asp Trp Arg Arg His Val Val Arg Leu Gin Pro 225 230 235 240 Gin Arg Leu Val Arg Arg Tyr Arg Asn Ala Arg Glu Gly Asp Ile Ala

245 250 255

Gly Val Ala Glu Arg Val Phe Asp Thr Trp Arg Cys Thr Leu Arg Thr

260 265 270

Thr Leu Leu Asp Phe Ala His Gly Val Val Asp Cys Phe Ala Pro Gly 275 280 285

Gly Pro Ser Gly Pro Thr Ser Phe Pro Lys Tyr Ile Asp Trp Leu Thr

290 295 300

Cys Leu Gly Leu Val Pro Ile Leu Arg Lys Thr Arg Glu Gly Glu Ala 305 310 315 320 Thr Gin Arg Leu Gly Ala Phe Leu Arg Gin His Thr Leu Pro Arg Gin

325 330 335

Leu Ala Thr Val Ala Gly Ala Ala Glu Arg Ala Gly Pro Gly Leu Leu

340 345 350

Glu Leu Ala Val Ala Phe Asp Ser Thr Arg Met Ala Glu Tyr Asp Arg 355 360 365

Val His Ile Tyr Tyr Asn His Arg Arg Gly Glu Trp Leu Val Arg Asp

370 375 380

Pro Val Ser Gly Gin Arg Gly Glu Cys Leu Val Leu Cys Pro Pro Leu 385 390 395 400

Trp Thr Gly Asp Arg Leu Val Phe Asp Ser Pro Val Gin Arg Leu Cys

405 - 410 415

Pro Glu Ile Val Ala Cys His Ala Leu Arg Glu His Ala His Ile Cys 420 425 430

Arg Leu Arg Asn Thr Ala Ser Val Lys Val Leu Leu Gly Arg Lys Ser

435 440 445

Asp Ser Gly Val Ala Gly Ala Ala Arg Val Val Asn Lys Ala Leu Gly

450 455 460 Glu Asp Asp Glu Thr Lys Ala Gly Ser Ala Ala Ser Arg Leu Val Arg

465 470 475 480

Leu Ile Ile Asn Met Lys Gly Met Arg His Val Gly Asp Ile Asn Asp

485 490 495

Thr Val Arg Ala Tyr Leu Asp Glu Ala Gly Gly His Leu Ile Asp Thr 500 505 510

Pro Ala Val Asp His Thr Leu Pro Gly Phe Gly Lys Gly Gly Thr Gly

515 520 525

Arg Gly Ser Ala Ala Gin Asp Pro Gly Ala Arg Pro Gin Gin Leu Arg

530 535 540 Gin Ala Phe Gin Thr Ala Val Val Asn Asn Ile Asn Gly Met Leu Glu

545 550 555 560

Gly Tyr Ile Asn Asn Leu Phe Gly Thr Ile Glu Arg Leu Arg Glu Thr

565 570 575

Asn Ala Gly Leu Ala Thr Gin Leu Gin Ala Arg Val 580 585

(2) INFORMATION FOR SEQ ID NO: 119:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21035 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 119:

GTCTGGCCGC CGGCCCTGGC GTACGCGCTA TATAAGCCCA TGCGGTATTG GATGAGTTCC 60

CGCGCGCCCC GGAACTCCTC CACCGCCCAC GGGGCCAGGT CCGCGGCCGC CGCGTCGAAC 120 TCCGCCAGCA GGCGCCCCAG GGCGTCAAAG TTCATCTCCC AGGGCACCCT GCGCACCACC 180

TCATCCCGCA GCCGGGCGCA CAGGGCGGTG TGCTTGGTGA CGCGCGCGCC CAGCTCCTCC 240

ACGGCCTCCG CGCGCTCGGC GCCCTTGGCG CCCAGGACGC CCTGGTACCT GGCGGAAAGG 300

CGCTCGTAGG CCGGCTGGGC CCGCAGCCCC GACACCGTGT TGGTGGTGTC CTGCAGGGCG 360 CGCAGCTGCT CGTGCATGGC GCGGAACCCC TCGGGGGACT TCCAGGCGCC CCCCCGGACG 420

CGGCCAAAGC GACCCCAGAC CTCGTCCCAC TCCGCCTCGG CCTCCTCCAG GGACCTCCGC 480

AGGGCGTCGA CGCGGCGCCG AGTATCAAAG AGCGCCCCCA GGCGGCCGGC GTGCCGCGCC 540

AGGGGGCCGG GGCCGTCGCC GCGGGCGGCG CTTAGCGGGT GCGTCTCGAA GGTGCGCTGG 600 GCGTGCTCTA GCCAGATAAC CGCGGGCACG TCGAGCTCGC GCGTTTTCTC GGTCTGATCC 660

AACAGAACCT CGACCTGGTC GGCGATCTCC GCCACCGAGC GCGCCTGGTC GAGCGTCTTG 720

GCCACGGTCG CCGGGACGGC GACCACCTTC AGCATGGTCT TGAGGTTGGC CAGGCCCTCG 780

GCCTCGATCT GGGCCCGGCG CTCGCGCGCG GCCAGCGCCT CCCGCAGGCC CGCCATGACC 840

CGCTCGGTGG CCTCCGCGCG CTGCTGTTTG GCGCGCACCA CTGCGTCCTT GGTCTCGGCC 900 GTGTCCTGCC GGGTCACGAA GGCGACATAC TCGGCGTACG CCGTGTTCTT CACGGGGCTC 960

TGGTCCACGC GCTCCAACGC CGCCGCGCAC GCGACCAGCG CGTCCTCGCT GGGACACGGC 1020

AGGGTGACCC CGGTCCGGAC CAGCTCCGCG GTGGCCTCCG GGTCATTCCG GGCCGCGGAT 1080

ATCTGCTCCG CGGCGGCCGC CAGGTCCAGG GGCACGCCGC CGAGCGCCCG GTGCACGTCG 1140

GCCCGGATGG CGTCCAGGCG ATCGCGGAGC TCCACGTAGT CGGCGTAGCC ATGTTGGAAG 1200 AACGGCACGT ACCGGCGCAG GCCGGGCACG CTCGTCATGT CGTCCGCCAG GCGCCCCACG 1260

GCCTCGTGGT AGTCGATAAA CCCGTCGCCC GCCTGGGCCA TTTCCAGGAG CCCCTCCGCG 1320

ATGCGCAGCA GCCGCGCCAG GGGCTCGGCG TCGACCCGAA ACATGTCGGC GTAGGTTTCG 1380

GCGGCGGCGT GGAACGCCGC GCTCCAGCCG AGGCGGTGGA TGGCGGCGAG CGGGGGGAGC 1440

ATGGGGTGGC GCTGGTTCTC GGGGGTGTAG GGGTTAAACG CGAAGGCCGT ATCCAGGGCG 1500 AGGGTGACCG CCTCGGCGTT GGCCGCGAGC GCCTGCTCGG CGCGCTTGCG GAAGTCCCGG 1560

GGGTTGTAGC CGTGCGTGCC CGCCAGCGCC TGCAGGCGGC GCAGCTCGAC CACGTCGAAC 1620

TCGGCGCGGT TCTCGACGCG GTCCAGCGCC GCCTCGACGC CGGCGGCCCA GCGCTCGCTG 1680

CTGCCCCGGG CGCGCTGGGC CGCCATCTTC GCCGTCAGGT CGGCGACGGC GGCCTCAAGT 1740

TCGTCGGCGC GGCGTCGCGT GGCGCCGATG ACCTTGCCCA GCTCCTGCAG GGCGCGCCCG 1800 CTGGGGGAAT GGTCCCCGGC CGTCCCTTCG GCGTGCAGCA GGCCCCCGAA CCCAGCCTCG 1860

TGCCCCGCGA GGCTTTCCCG AGCAGCGGTC GTCGCGCGGG CCGCGGCATC GATGAGGGCG 1920

GCATGGTCCC CCTCCGGCTG GGCGCAGGCC CGGCGCGCCT GGACTACCAG GTCGGCGGCC 1980

GCCGACCCCA GGGTCGTGAG CTCGTCGATG GCCCCCCGCG CCTCCAGGGC CAGCCGAGTC 2040

GCCTTTACAT ACCCCGCGGC GCTATCGGCC AGCGCCGCGA GGAAGGACAG GGGCGAGGCC 2100 GGGTCGCGGG CGGCCGCGCC CAGGGCCGAC ACCGCGTCCG CCAGGGCGCC ATGCGCCCGC 2160

ACGGCCGCGT CCACCGTCGC CGCGGGACTT GCCGTCGCGA CGGCGGCGCT CCCGGCGTTG 2220

ATGGCGTTTG ACACGGCTTT GGCGATTGTG GGGGCGTGAT CGGAAAAGAA CTGCACGAGG 2280

ACCGGCGTCT CGGGGGCGTC GGCGAACAGG GTCTTCAGCA CCACCACGAA GGCGGGATGC 2340

AGGCCGGCCA GAGCCGTCGC GGTATCCGGG GTCGGGTGTT CCAGGGCCTC CCGGTACTGC 2400 CCCAGCAGCC CCCACAGGTC CGCCCGCAGC GCCGCCGTGA CTTCCGGGGG GGGGCCCCGG 2460

ACGGCATCGG CCAGGTCGGT CCACCCCGCG GGCAGGGAGG CCCGCAGGGT CGCCAGCACG 2520

GCCGGACACG CCTTTAGCCC CACAAAGTCC GGGAGGGGCC GCAGGACCCC TTGGAGTTTG 2580

TGCAGGAACT TCTCCCGGGC GTCGTGGGCC ACCTTGGCGC GCTCCCGCGC GTCGTTGAGC 2640

ATCGCCTCCA GGGCGTGGGC GCGCTCCCGA AGCCGGGAGC GCGCCTCCGG AGCGAGCTCC 2700 GCCGTCATCT TGGCCGCCTC CATGGCCCTC GCCTGCCGCA GCGCGTCTTC GGCCATGCGC 2760

GTGGCCTCGG GGGACAGCCC GCCCCCGTCG ACGTACGGCG CGGGGCCGGT CGCCGGGACG 2820

AAGGCCGCGT CGCTGTCCAG CTGCTGCGCG AGCGCCGCGT CGAGGGCGTC GAAGCGCTGC 2880

AGTTCGGCCA GCCCCGAGCT GCGCCGCGCC TGCTGGTCGT TGATGCCGTG GATGCTGCGC 2940 GCCAGCTCTT CCAGGGGCTT GCGTTCGATG AGCCCCTGGG TCGCGGCGTC GGTCAGGACC 3000

GAGAGCCAGG CCGCCAGGTC CTCGGGGGCA TCTAGGGTCT GGCCCCGCTG GAGCAGGTCC 3060

CGCAGCAGGA TGGCCTGGGG GCTGGTGGCG AGGGGGGGCG GGGGGGGGAG CGCGGCGCGC 3120

TGAGCGACGT CCCGCGTGTG TTGGTCAAAG GCCGGTAGCG ATTCCAGCAA CTGGACCATG 3180 GGCACGACCG CGGCCGAGGC CACGTGAAAC CGACAGTCGT GGCTGTCGCT GGCCTGCAGG 3240

GCCTTCGCGC TGTATACGGC TCCCCGGTGG AAGTACTCCT TGATCGCGCT CTCGATCGCC 3300

CGGCGGGCCT GGATCCGCAC GTCCTCCAGC CGCGCCTGGA TGGCCTCGGG GCCCAGGGCG 3360

GGCGGGCACG GGGCCCTGCC GCCGGCGCCC GGGGCGGCGG GCACGGGCAT CACGGTCAGG 3420

GGCCCGGCGC GCTGCGAGAC CGAGTCGACC CCGCGGGCGA GGGCGTCTAA GGCCTCGCGC 3480 ATCTCGCGGG CCTCCGCCTC GACCCGCATC TCTTCGCCCC GGGCAAACTG GGCCAGCGCC 3540

TGGATCCGAT GGAGAAGCGG CTCCGGGTGC GTCGGGGTGG CGGGGGCGAA CAGGGTGTTC 3600

GGGTGGGCGC GCGAGCGCTC CAGGAGCCAC TCTCCGAGGC GTGCGTACAG ATTGGCCGGC 3660

GGGGCGGCGC GCAGCTGCAG ATCCAGGTCC GCGAGGTCCC CGTAAAAGGC GTCCGTCTCC 3720

CGAATAACGT CCCTGGCGAC CAGGACCAGC TTAGCGAGGG CCAGGCGCCC GATCTGCGAA 3780 TTTTCGTCCA GCACGTGCTG GATGAGGGGC CGGTGGGCGG CCACGTCCGC CAGGCTCATG 3840

CGCGTGGACG CCAGGAAGTC CCCGACGGCC GTTTTGCGGG GCAGCATGCG CAGGGTGAAG 3900

TCCAGCAGGG CCGCGGCCGG GCCGGCCACC CCGGCCTGCG TATGCGTGCG GGCCCCGTTC 3960

TCGATCAAAA AGGCGAGGAC GCGCTCAAAG AAGAAGATGA CGCAGAGCTC CAACAGCCCC 4020

GGGTGCGCCG GGTACGGCGA CCGCAGGGCG TTGATGGTGA GCTGCGAACA CGCGGCCACC 4080 TCGCGGGCCA GGGCGGCATC GCGCGCCGCG AGCCGGACCG CCGTGGCGGC CACATTGGGG 4140

TGGACCTCGA ACAGCTGCGC CAGGTCGGCG CCGGGGGGCT CCGGGGGGCG GCGGGCCCCC 4200

AGCGTCTCGA GCACGGACGG CGACGACGGG CTCGCGGGCC CGTCATCGCC GCCTCCCTGC 4260

CCGGACTGCG GGGGGGTATC CGGTGCGGGA GGGACCGTGG CGGCTATGGG CGTCGGGGAG 4320

GAGGCGGGGA CCTCGGCGGC GACGGGGGCC TTCTTCTTGG GCGCGGACTT CTTCTTGGCC 4380 TTGGCGGGCG GGGCCTTGGG GGCGGGCCTC TCGCCCGAGG TCAGATCCTC CACGCTGGAC 4440

GGTGGGGTCC AGGTGGGCCG GCGGCGCTTG GGCAAGCCGG TAGAATAGCG CGCCCGGTGG 4500

CGACCCACCG GCACTGCCCC CACCTCCAGG ACCCGCAGGT CCTCGGCTTC TTCGGCCGCG 4560

TCCCCGGCGG GTGTCTGCGG GGGCGGGGCG GCGTGCGGTG GACCCGAGGC CGCGGCGTCC 4620

GGGGCCGAGG GCTTTGCGGG CGGGGTCCCC TCCAGGGCTG CTGCCCACAC ATCATCGGGG 4680 GGGCGGTTTG GGTGCCCCGC CTGCGGTGTG TTGGGTGGGC CCGAGGCCCC CCGGGGGGCC 4740

TCGGGGGGCC GGTCGGCCCG AGGGGTCTGG ACGTGGGTGG GCGCGGGGAG CGCGGGGACG 4800

ACCGGGCCCG AGCCTTCTCC GTCCCCCCTG GGGACCACAC CGACAAAGAG CGCCCCTAGC 4860

CCCCCGATCT CGCCCCGCAG GGGGTGGGTG ATGGCCACGC GCCGCTCGAC GAACGGTTCG 4920

TCCTGCAGGT AAGTCTCGCT GGCCCCGTAG AGGTGCAGGG CCGCGGCGGT CAGGTCCGCC 4980 GGCGCCACGG CCCCCGGGCC GGAGGGCACA AAAAACACCA TGGCGCCCGC CCACCGCACC 5040

TTGGGGCGGT CGTGGGCGTA ATACGTCAGG TACGGGTACA CGTCGCCCGC CCGCACCTTG 5100

GCGATAAACG CGGGCGTTCC CGCGGGCAGG CCGTGCGGGT CAAACAGATA GGCCGTGTCG 5160

CCGTCCCGGT AGAGCCCCAT GCCCAGGGGG CCGATGGTCA GGAGCGTGTA GGACAGCGGC 5220

CGCATGGCCC AGGGGCCGGC GAAGAACGTG TGCGCGGGGC ATTGCGTCTC CAGCAGCCCC 5280 GCCGTGGGCT CCCCGAAGAA GCCCACCTCG CCGTACACCC GCGAAAACAC GCAACGCAGG 5340

CCGCCGCGCG CCGCCGGGTA CTCCAGGAAG TTGGGGAGCT CGATAATGGA ACACATGCGC 5400

GGCGGCCCGG AGCCCGCGGC CGCGCGCGTC CACTCGCCCC CCTCCACCAG ACATCCCTCA 5460

ATGGCCTCCG CGGACAGCAC GTCGCGGGGC CCCACGTCGA AAAGAAGACT GAGAAACGAC 5520 AGGGACGAGC GCATGCACGA TACCGACCCC CCCGGCTCCA GATCGGTCGC GAACTGGTTC 5580

CGAACACCGG TGACCACGAT ATCGCGATCC CCCTGGCGCT TCATCGTGGG GTGAGGTAGC 5640

GCGGCCGGAA TCATGTGTGC CGCGCCCGCC ACGAGCGGGG CCTGTTTATG GGCCGGGCGT 5700

CCCGATGAGT ACTGTTGTTT CCGCCGCCCG AACCCCCCCC GCCCATCAAC CGCCTGTTCG 5760 TCCCCCTAAC CACACACCCG GTATCGCGTG TGTGGTTTCC CGGGAAGCCA CATCCCACCC 5820

CATGAAGTTT TGCCCTTTTT TTCCGTCCCG CACTACGCCA CCTTTCCACC CCCCCCCCCC 5880

AAAAAAAAAA AAACAACAAC CAACTCCCAG ATGGATGGGT GCGATAATAA AGCTTTATTA 5940

TTGTTTAACC AAAGGCGAGT CCTACGGGTG TACCGGTGGT GTCTCCTGCG GCGTCATCTC 6000

GTCGTCCTCC ACGGGGGTGT TGGGCCAAGG GACCGTCTCG CGGCCCGCCG GGCGCGTCGA 6060 CGGCGCGCGG GCCTGCGTGT CCTGTGGGCC GGGTGTCGTG GGTTCGGGGG TGCTACCGCC 6120

GGCATCTTGG GCCTCCAGGT CCCCGGGGGC CTCCGGGCCG GCGGAAGGCC GAAACGCCGA 6180

GGCGCGAAAC ACGCCGTCGG TGACCTGCAG GAGCTCGTTT ATTAATAGCC AGTCCATGCT 6240

CAGCGTAGCG GCCAGCCCCT GGGGAGACAG GTCCACGGAG TCCGGAACCA CCGTCGGCTG 6300

ACCCAGGGGC CCCAGGCTGT AGTCCCCCCA GGCCCCCAGG TCATGACGGT TCGTGAGCAC 6360 GACGAGGTCT GCGGCCGGGC TGGGGGGCGC GTCCTCGGTC GCGTGGGCCA TCACCTCCTG 6420

AATGGCTGCG GTGCGCTGAT CGGCCGAGCT GGCGAAGGGC GCCACGACCA GCGCGCGCTC 6480

CGTCTGCAGG CCCTTCCACG TGTCGTGGAG TTCCTGAACG AACTCGGCCA CCCGCTCGGG 6540

GCCCGTGGCC GCGCGCGCGG CCTGATAGCC GGCCGAGAGG CGCCGCCAGC GCGCCAGGAA 6600

CTGACTCATG TAACAGAACC CGGGGACCTG GTCCCCCGAC ATCAACTTTG ACGCCCTGGC 6660 GTGGATGCCC GACACGATGG CCAGGAACCC GTGGATTTCC CGCCGCACGA CGGCCAGCAC 6720

GTTACCCTCG TGCGAGACCT GGGCCGCCAG CTCGTCGCAT ACCCCGAGGT GCGCCGTCGT 6780

CTCGGTGACG ACGGACCGCA GCCCCGCGAG GGACGCGACC AGCGCGCGCT TGGCGTCGTG 6840

ATACATGCCG CAGTACTGGC TCACCGCGTC GCCCATGGCC TCGGGGCGCC AGGGCCCCAG 6900

GCGCTCGTGG GCGTCTGCGA CCACGGCGTA CAGGCGGTGC CCGTCGCTCT CGAACCGGCA 6960 CTCAAAGAAG GCGGCGAGCG TGCGCATGTG CAGCCGCAGC AGCACGATCG CGTCCTCCAG 7020

CTGGCGGACC AGGGGGTCGG CGCGCTCGGC GAGCTCCTGC AGCACCCCCC GGGCCGCCAG 7080

GGCGTACATG CTGATCAGCA GCAGGCTGCT GCCCACCTCG GGAGGCTGGG GGGGAGGCAG 7140

CTGGACCGCG GGCCGCAGCT GCTCGACGGC CCCCCTGGCG ATCACGTACA GCTCGCGCAG 7200

CAGCTGCTCG ATGTTGTCGG CCATCTGCAT CGTGGGCCCG ACGCCGGCCC GGGTGGCCGG 7260 TTCGAGGAGG GTGATCAGCG CGCCCAATTT TGTGCGGTGC CCCTCGACGG TGGGGAGATA 7320

GCCCAGGCCG AAGTCGCGCG CCCAGGCCAG CACCCGCAGG GCAAACTCGA TGGGGCGGGG 7380

CAGGTAGGCA GCGTTGCACG TGGCCCTCAG CGCGTCCCCG ACCACCAGGG CCAGCACGTA 7440

AGGGACGAAC CCCGGGTCGG CGAGGACGTT GGGGTGGATG CCCTCCAGGG CCGGGAAGCG 7500

GATCTTGGTG GCCGCGGCCA GGTGAACCGA GGGGGCGTGG CTAGGCGGCC CGACGGGGAG 7560 CAGCGCGGAC AGCGGCGTGG CCGGGGTGGT GGGGGTCAGG TCCCAGTGGG TCTGGCCGTA 7620

CACGTCGAGC CAGATGAGCG CCGTCTCGCG CAGGAGGCTG GGCTGGCCGG CGCTGAAGCG 7680

GCGCTCGGCC GTCTCAAACT CCCCCACGAG CGTGCGCCGC AGGCTCGCCA GGTGTTCCGT 7740

CGGCACGGCC GGGCCCATGA TGCGCGCCAG CGTCTGGCTG AGGACGCCGC CCGACAGGCC 7800

GACCGCCTCA CAGAGCCGCC CGTGCGTGTG CTCGCTGGCG CCCTGGATCC GCCGGAACGT 7860 TTTCACGTAG CCGGCGTAGT GCCCGTACTC CCGCGCGAGC CCGAACACGT TCGCCCCCGC 7920

AAGGGCAATG CACCCAAAGA GCTGCTGGAT CTCGCTGAGC CCGTGGCCGG GGGGCGTCCG 7980

CGCGGGCACC CCCGCCACCA AAAACCCCTC CAGGGCCGAT ATGTACTGGG TGCAGTGCGC 8040

GGGCGTGAAC CCCGCGTCGG TAAGCGTGTT GATCACCACG GAGGGCGAGT TGCTGTTCTG 8100 GACCAAAGCC CACGTCTGCT GCAGCAGCGC GAGGAGCCGT TGCTGGGCCC CGGCGGAGGG 8160

CGGCTCCCCT AGCTGCAGCA GGCCGGTGAC GGCCGGACGG AAGATGGCCA GCGCCGACGC 8220

ACTCAGAAAC GGCACGTCGG GGTCGAAGAC GGCCGCGTCC GTCCGCACGC GCGCCATCAG 8280

CGTCCCCGGG GGCGCGCACG CCGACCGCGG GCTGACGCGG CTTAGGGCGG TCGACACGCG 8340 CACCTCCTCG CGACTGCGAA CCATTTTGGT GGCCTCGAGG GGCGGGATCA TGATAGCCGG 8400

GTCGATCTCC CGCACCGTGT GCTGAAACTG GGCCAGCAGC GGCGGCGGGA CCACCGCGCC 8460

CCGATCGGGG GTCGTCAGGT ACTCGTCCAC CAGCGCCAGC GTAAACAGGG CCCGCGTGAG 8520

GGGGGTCAGG GCGGCGTCGT CGATGCGCTG TAGGTGCGCC GAGAACAGCG TCACCCAATT 8580

GCTGACCAGG GCCAAGAACC GGAGACCCTC TTGCACGATC GGGGACGGGA AGAGCAGGCT 8640 GTACGCCGGG GTGGTCAGGT TGGCGCCGGG TTGCCCCAGG GGAACCGGGG ACATCTTAAG 8700

CGACATCTCC CCGAGGGCCT CCAGGGAGGT CCGCGGGTTC ATGGCCAGGC AGCTCTGGGT 8760

GACGGTCCGC CAGCGGTCGA TCCACTCCAC GGCACACTGG CGGACGCGCA CCGGCCCCAG 8820

GGCCGCCGTG GTGCGCAGCC CGGCGGCCTC CAGCGCGTGG GTCGTGTCGG AGCCGGTGAT 8880

CGCCAGGACC GTGTCCTTGA TGACGTCCAT CTCCCGGAAG GCCGCCTCGG GGGTCTCGGG 8940 GAGCGCCACC GCCATGCGGT GCACCAGCAG CCCGGGGAGG TTCTCGGCCA AGAGCGCCGT 9000

CTCCGGAAGC CCGTGGGCCC GGTGCAAGGC GCACAGTTGC TCCAGGAGCG GGTGCCAGCA 9060

CGCCCGCGCC TCCGCCGGGC CGACCGCCGC GCCCGACAAC AGAAACGCCG CCGTGGCGGC 9120

GCGCAGTTTG GCCGCGGACA GAAACGCCGG CTCGTCCGCG CTGCCCGCCG GCTCGCTCGA 9180

GGGGGAGGGC GGCCGGCGGA GGTTGGTCAG GCTCCCCAAC AGGACCTGCA ACGGTCCGTT 9240 TGGGGGTGGA GCGGACGGGG GGGTCATGCC GGCGGGCGCC GGGACCTGGA GCGCGCTGTC 9300

CGACATGGCG ACCGGCGTGC GCGCTCGGCG ACGCGGCGCG GAGACCGCGG GCCCAAACGG 9360

GAATGACTGC CGCCGCCCTA TACGGAGGGG CTAAGTATCG CCCGGGGACC CTTCGAAACC 9420

CCGGGCGTGT CGCAAGTACG CCGCGAAGGC GCGGCGTGTT ATACGGCGCG TTATGTCCCG 9480

GCATTCCGTT CGTGGGTTCG GGCCCGGGTG CTGTCGGGTG GGAGTGTGTG TGTGTGGGGG 9540 GGGGGCGGCG CGACGGCGGC CCGGACCAAG TGTATCGCGG CCGTTCCGTG GGGCGGCCCA 9600

ACAGGCCCTT TAAACATTTG CGTATGCACC GGCCCAGCCA GTCGGACACC GGAACCCACC 9660

AGAGGCGGAA GCCGCCTTCG CCCGTGAGGG TGCGTGTGTT TTCTGGTGGC GTGTTTTTCC 9720

TTTCCGCCCT CCTCCCTCCC CACCTCCACC ACCCCCCCCC CACAACTCGC CCGTTGGCGA 9780

TCGGCGGGAA AACCATGAAA ACCAAGCCAC TCCCGACAGC CCCGATGGCG TGGGCCGAGA 9840 GTGCCGTGGA AACCACCACC AGCCCGCGCG AGCTCGCGGG CCACGCCCCG CTCCGGCGCG 9900

TCCTGCGCCC GCCCATCGCT CGCCGCGACG GCCCGGTGCT TTTGGGGGAC AGGGCCCCCA 9960

GGAGGACGGC CAGTACGATG TGGCTGCTGG GGATCGACCC CGCGGAGTCG TCTCCGGGAA 10020

CGCGCGCTAC CCGAGACGAT ACCGAGCAGG CCGTGGACAA GATCCTCAGG GGAGCCCGGC 10080

GCGCGGGAGG GCTGACCGTC CCCGGCGCCC CCCGCTATCA CCTGACCCGC CAGGTAACCC 10140 TGACGGATCT CTGCCAACCA AACGCGGAGC GGGCCGGGGC GCTCCTTTTG GCCCTGCGGC 10200

ACCCCACCGA CCTCCCCCAC CTGGCCCGCC ATCGGGCTCC GCCCGGCCGG CAGACCGAGC 10260

GACTGGCCGA GGCCTGGGGC CAGCTCCTGG AGGCCTCCGC CCTGGGGTCC GGGCGGGCCG 10320

AGAGCGGCTG CGCGCGCGCG GGCCTTGTGT CGTTTAACTT TCTGGTGGCC GCGTGCGCCG 10380

CCGCCTACGA TGCGCGCGAC GCCGCCGAGG CGGTCCGGGC CCACATCACG ACCAACTACG 10440 GCGGGACGCG GGCCGGGGCG CGGCTGGACC GGTTTTCCGA ATGCCTGCGC GCCATGGTCC 10500

ACACGCACGT GTTTCCCCAC GAGGTCATGC GGTTTTTCGG GGGGCTAGTG TCGTGGGTCA 10560

CACAGGACGA GCTGGCTAGC GTCACCGCCG TCTGCAGCGG ACCCCAGGAG GCCACACACA 10620

CCGGCCACCC GGGCAGGCCC TGTTCGGCCG TTACCATCCC GGCCTGCGCC TTCGTGGACC 10680 TGGACGCCGA GCTGTGCCTG GGGGGCCCTG GGGCGGCGTT CCTGTACTTG GTCTTCACCT 10740

ACCGACAGTG CCGGGACCAG GAGCTCTGTT GCGTGTACGT GGTCAAGAGC CAGCTCCCCC 10800

CGCGCGGACT GGAGGCGGCC CTCGAGCGGC TGTTCGGGCG CCTCCGGATA ACCAACACGA 10860

TTCACGGGGC CGAGGACATG ACGCCCCCTC CCCCGAACCG AAACGTTGAC TTTCCGCTCG 10920 CCGTCCTGGC CGCGAGCTCG CAATCCCCGC GGTGCTCGGC GAGCCAAGTC ACGAACCCCC 10980

AGTTTGTCGA CAGGCTGTAC CGCTGGCAGC CGGATCTGCG GGGGCGCCCT ACCGCACGCA 11040

CCTGCACATA CGCCGCCTTC GCAGAGCTGG GTGTCATGCC AGACAACAGC CCCCGCTGTC 11100

TGCACCGCAC CGAGCGGTTT GGGGCGGTCG GCGTTCCGGT TGTCATCCTG GAGGGCGTGG 11160

TGTGGCGCCC CGGCGGGTGG CGGGCCTGCG CGTGATCGTC TATTGACGAC GGCCGCCCAA 11220 CCCGAGCGAC CTTCCCCTCC CACTTTCCCC CCCCCCCCTC CTACACACCA ACTCCGCCCT 11280

CGCCGTCTTG GCCGTGCGCG GCCCCGTGCG TCCGTCTCAA TAAAGCCAGG TTAAATCCGT 11340

GACGTGGTGT GTTTGGCGTG TGTCTCTGAA ATGGCGGAAA CCGACATGCA AATGGGATTC 11400

ATGGACACGT TACACCCCCC TGACTCAGGA GATAGGCATA TCCTCCTTAG ATTGACTCAG 11460

CACACGATCG CACCCCACCC CTGTGTGCCG GGGATAAAAG CCAACGCGGG CGGTCTGGGT 11520 TACCACAACA GGTGGGTGCT TCGGGGACTT GACGGTCGCC ACTCTCCTGC GAGCCCTCAC 11580

GTCTTCGCCC ACCGATTCCT GTTGCGTTCC TGTCGGCCGG TGCTGTCCTG TCGACAGATT 11640

GTTGGCGACT GCCCGGGTGA TTCGTCGGCC GGTGCGTCCT TTCGGTCGTA CCGCCCACCC 11700

CGCCTCCCAC GGGCCCGCCG CTGTTTCCGT TCATCGCGTC CGAGCCACCG TCACCTTGGT 11760

TCCAATGGCC AACCGCCCTG CCGCATCCGC CCTCGCCGGA GCGCGGTCTC CGTCCGAACG 11820 ACAGGAACCC CGGGAGCCCG AGGTCGCCCC CCCTGGCGGC GACCACGTGT TTTGCAGGAA 11880

AGTCAGCGGC GTGATGGTGC TTTCCAGCGA TCCCCCCGGC CCCGCGGCCT ACCGCATTAG 11940

CGACAGCAGC TTTGTTCAAT GCGGCTCCAA CTGCAGTATG ATAATCGACG GAGACGTGGC 12000

GCGCGGTCAT TTGCGTGACC TCGAGGGCGC TACGTCCACC GGCGCCTTCG TCGCGATCTC 12060

AAACGTCGCA GCCGGCGGGG ATGGCCGAAC CGCCGTCGTG GCGCTCGGCG GAACCTCGGG 12120 CCCGTCCGCG ACTACATCCG TGGGGACCCA GACGTCCGGG GAGTTCCTCC ACGGGAACCC 12180

AAGGACCCCC GAACCCCAAG GACCCCAGGC TGTCCCCCCG CCCCCTCCTC CCCCCTTTCC 12240

ATGGGGCCAC GAGTGCTGCG CCCGTCGCGA TGCCAGGGGC GGCGCCGAGA AGGACGTCGG 12300

GGCCGCGGAG TCATGGTCAG ACGGCCCGTC GTCCGACTCC GAAACGGAGG ACTCGGACTC 12360

CTCGGACGAG GATACGGGCT CGGGTTCGGA GACGCTGTCT CGATCCTCTT CGATCTGGGC 12420 CGCAGGGGCG ACTGACGACG ATGACAGCGA CTCCGACTCG CGGTCGGACG ACTCCGTGCA 12480

GCCCGACGTT GTCGTTCGTC GCAGATGGAG CGACGGCCCT GCCCCCGTGG CCTTTCCCAA 12540

GCCCCGGCGC CCCGGCGACT CCCCCGGAAA CCCCGGCCTG GGCGCCGGCA CCGGGCCGGG 12600

CTCCGCGACG GACCCGCGCG CGTCGGCCGA CTCCGATTCC GCGGCCCACG CCGCCGCACC 12660

CCAGGCGGAC GTGGCGCCGG TTCTGGACAG CCAGCCCACT GTGGGAACGG ACCCCGGCTA 12720 CCCAGTCCCC CTAGAACTCA CGCCCGAGAA CGCGGAGGCG GTGGCGCGGT TTCTGGGGGA 12780

CGCCGTCGAC CGCGAGCCCG CGCTCATGCT GGAGTACTTC TGTCGGTGCG CCCGCGAGGA 12840

GAGCAAGCGC GTGCCCCCAC GAACCTTCGG CAGCGCCCCC CGCCTCACGG AGGACGACTT 12900

TGGGCTCCTG AACTACGCGC TCGCTGAGAT GCGACGCCTG TGCCTGGACC TTCCCCCGGT 12960

CCCCCCCAAC GCATACACGC CCTATCATCT GAGGGAGTAT GCGACGCGGC TGGTTAACGG 13020 GTTCAAACCC CTGGTGCGGC GGTCCGCCCG CCTGTATCGC ATCCTGGGGA TTCTGGTTCA 13080

CCTGCGCATC CGTACCCGGG AGGCCTCCTT TGAGGAATGG ATGCGCTCCA AGGAGGTGGA 13140

CCTGGACTTC GGGCTGACGG AAAGGCTTCG CGAACACGAG GCCCAGCTAA TGATCCTGGC 13200

CCAGGCCCTG AACCCCTACG ACTGTCTGAT CCACAGCACC CCGAACACGC TCGTCGAGCG 13260 GGGGCTGCAG TCGGCGCTGA AGTACGAAGA GTTTTACCTC AAGCGCTTCG GCGGGCACTA 13320

CATGGAGTCC GTCTTCCAGA TGTACACCCG CATCGCCGGG TTCCTGGCGT GCCGGGCGAC 13380

CCGCGGCATG CGCCACATCG CCCTGGGGCG ACAGGGGTCG TGGTGGGAAA TGTTCAAGTT 13440

CTTTTTCCAC CGCCTCTACG ACCACCAGAT CGTGCCGTCC ACCCCCGCCA TGCTGAACCT 13500 CGGAACCCGC AACTACTACA CGTCCAGCTG CTACCTGGTA AACCCCCAGG CCACCACTAA 13560

CCAGGCCACC CTCCGGGCCA TCACCGGCAA CGTGAGCGCC ATCCTCGCCC GCAACGGGGG 13620

CATCGGGCTG TGCATGCAGG CGTTCAACGA CGCCAGCCCC GGCACCGCCA GCATCATGCC 13680

GGCCCTGAAG GTCCTGGACT CCCTGGTGGC GGCGCACAAC AAACAGAGCA CGCGCCCCAC 13740

CGGGGCGTGC GTGTACCTGG AACCCTGGCA CAGCGACGTT CGGGCCGTGC TCAGAATGAA 13800 GGGCGTCCTC GCCGGCGAGG AGGCCCAGCG CTGCGACAAC ATCTTCAGCG CCCTCTGGAT 13860

GCCGGACCTG TTCTTCAAGC GCCTGATCCG CCACCTCGAC GGCGAGAAAA ACGTCACCTG 13920

GTCCCTGTTC GACCGGGACA CCAGCATGTC GCTCGCCGAC TTTCACGGCG AGGAGTTCGA 13980

GAAGCTGTAC GAGCACCTCG AGGCCATGGG GTTCGGCGAA ACGATCCCCA TCCAGGACCT 14040

GGCGTACGCC ATCGTGCGCA GCGCGGCCAC CACCGGAAGC CCCTTCATCA TGTTTAAGGA 14100 CGCGGTAAAC CGCCACTACA TCTACGACAC GCAAGGGGCG GCCATTGCCG GCTCCAACCT 14160

CTGCACGGAG ATCGTCCACC CGTCCTCCAA ACGCTCCAGC GGGGTCTGCA ACCTGGGCAG 14220

CGTGAATCTG GCCCGATGCG TCTCCCGGCG GACGTTCGAT TTTGGCATGC TCCGCGACGC 14280

CGTGCAGGCG TGCGTGCTAA TGGTTAATAT CATGATAGAC AGCACGCTGC AGCCGACGCC 14340

CCAGTGCGCC CGCGGCCACG ACAACCTGCG GTCCATGGGC ATTGGCATGC AGGGCCTGCA 14400 CACGGCGTGC CTGAAGATGG GCCTGGATCT GGAGTCGGCC GAGTTCCGGG ACCTGAACAC 14460

ACACATCGCC GAGGTGATGC TGCTCGCGGC CATGAAGACC AGTAACGCGC TGTGCGTTCG 14520

CGGGGCGCGT CCCTTCAGCC ACTTTAAGCG CAGCATGTAC CGGGCCGGCC GCTTTCACTG 14580

GGAGCGCTTT TCGAACGCCA GCCCGCGGTA CGAGGGCGAG TGGGAGATGC TACGCCAGAG 14640

CATGATGAAA CACGGCCTGC GCAACAGCCA GTTCATCGCG CTCATGCCCA CCGCCGCCTC 14700 GGCCCAGATC TCGGACGTCA GCGAGGGCTT TGCCCCCCTG TTCACCAACC TGTTCAGCAA 14760

GGTGACCAGG GACGGCGAGA CGCTGCGCCC CAACACGCTC TTGCTGAAGG AACTCGAGCG 14820

CACGTTCGGC GGGAAGCGGC TCCTGGACGC GATGGACGGG CTCGAGGCCA AGCAGTGGTC 14880

TGTGGCCCAG GCCCTGCCTT GCCTGGACCC CGCCCACCCC CTCCGGCGGT TCAAGACGGC 14940

CTTCGACTAC GACCAGGAAC TGCTGATCGA CCTGTGTGCA GACCGCGCCC CCTATGTTGA 15000 TCACAGCCAA TCCATGACTC TGTATGTCAC AGAGAAGGCG GACGGGACGC TCCCCGCCTC 15060

CACCCTGGTC CGCCTTCTCG TCCACGCATA TAAGCGCGGC CTGAAGACGG GGATGTACTA 15120

CTGCAAGGTT CGCAAGGCGA CCAACAGCGG GGTGTTCGCC GGCGACGACA ACATCGTCTG 15180

CACAAGCTGC GCGCTGTAAG CAACAGCGCT CCGATCGGGG TCAGGCGTCG CTCTCGGTCC 15240

CGCATATCGC CATGGATCCC GCCGTCTCCC CCGCGAGCAC CGACCCCCTA GATACCCACG 15300 CGTCGGGGGC CGGGGCGGCC CCGATTCCGG TGTGCCCCAC CCCCGAGCGG TACTTCTACA 15360

CCTCCCAGTG CCCCGACATC AACCACCTTC GCTCCCTCAG CATCCTGAAC CGCTGGCTGG 15420

AGACCGAGCT CGTGTTCGTG GGGGACGAGG AGGACGTCTC CAAGCTCTCC GAGGGCGAGC 15480

TCGGCTTCTA CCGCTTTCTG TTTGCCTTCC TGTCGGCCGC GGACGACCTG GTGACGGAAA 15540

ACCTGGGCGG CCTCTCCGGC CTCTTCGAAC AGAAGGACAT TCTTCACTAC TACGTGGAGC 15600 AGGAATGCAT CGAGGTCGTC CACTCGCGCG TCTACAACAT CATCCAGCTG GTGCTCTTTC 15660

ACAACAACGA CCAGGCGCGC CGCGCCTATG TGGCCCGCAC CATCAACCAC CCGGCCATTC 15720

GCGTCAAGGT GGACTGGCTG GAGGCGCGGG TGCGGGAATG CGACTCGATC CCGGAGAAGT 15780

TCATCCTCAT GATCCTCATC GAGGGCGTCT TTTTTGCCGC CTCGTTCGCC GCCATCGCGT 15840 ACCTGCGCAC CAACAACCTC CTGCGGGTCA CCTGCCAGTC GAACGACCTC ATCAGCCGCG 15900

ACGAGGCCGT GCATACGACA GCCTCGTGCT ACATCTACAA CAACTACCTC GGGGGCCACG 15960

CCAAGCCCGA GGCGGCGCGC GTGTACCGGC TGTTTCGGGA GGCGGTGGAT ATCGAGATCG 16020

GGTTCATCCG ATCCCAGGCC CCGACGGACA GCTCTATCCT GAGTCCGGGG GCCCTGGCGG 16080 CCATCGAGAA CTACGTGCGA TTCAGCGCGG ATCGCCTGCT GGGCCTGATC CATATGCAGC 16140

CCCTGTATTC CGCCCCCGCC CCCGACGCCA GCTTTCCCCT CAGCCTCATG TCCACCGACA 16200

AACACACCAA CTTCTTCGAG TGCCGCAGCA CCTCGTACGC CGGGGCCGTC GTCAACGATC 16260

TGTGAGGGTC TGGGCGCCCT TGTAGCGATG TCTAACCGAA ATAAAGGGGT CGAAACGGAC 16320

TGTTGGGTCT CCGGTGTGAT TATTACGCAG GGGAGGGGGG TGGCGGCTGG GGAAAGGGAA 16380 GGAACGCCCG AAACCAGAGA AAAGGACCAA AAGGGAAACG CGTCCAACCG ATAAATCAAG 16440

CGCCGACCAG AACCCCGAGA TGCATAATAA CAAACGATTT TATTACTCTT ATTATTAACA 16500

GGTCGGGCAT CGGGAGGGGA TGGGGGCGCG CGTTTCCTCC GTTCCGGCTA CTCGTCCCAG 16560

AATTTAGCCA GGACGTCCTT GTAAAACGCG GGCGGGGGCG CGTGGGCCCA CAGCTGCGCC 16620

AGAAACCGGT CGGCGATGTC CGGGGCGGTG ATATGCCGAG TCACGATGGA GCGCGCTAAA 16680 TCTTCGTCGC GGAGGTCCTG ATAGATGGGC AGTCTTTTTA GAAGAGTCCA GGGTCCCCGC 16740

TCCTTGGGGC TGATAAGCGA TATGACGTAC TTGACGTATC TGTGCTCCAC CAGCTCGGCG 16800

ATGGTCATCG GATCGGGCAG CCAGTCCAGG GCCTCCGGGG CGTCGTGGAT GACGTGGCGG 16860

CGACGTCCGG CGACATAGCC GCGGTGTTCC GCGACCCGCT GCGCGTTGGG GACCTGCACG 16920

AGCTCGGGCG GGGTGAGTAT CTCCGAGGAG GACGACCGGG CGCCGTCGCG CGGCCCACCG 16980 GCGACGTCCG GGGGCTGGAG GGGGGGGTCT TCTTCGTAGT CGTCCTCGCC CGCGATCTGT 17040

TGGGCCAGAA TTTCGGTCCA CGAGATGCGC GTCTCGAGGC CGACCGGGGC CGCGGTCAGC 17100

GTAGGCATGC TCTCCAGGGA GCGCGAGTTG GCGCGCTCCC GCCGGGCCGC CCGGCGGGCC 17160

TGGGATCGGC TCGGGGCGGT CCAGTGACAC TCGCGCAGCA CGTCCTCGAC GGACGCGTAG 17220

GTGTTATTGG GGTGCAGGTC TGTGTGGCAG CGGACGAACA GCGCCAGGAA CTGCGGGTAA 17280 CTCATCTTGA AGTACTGCAG CAGGTCGCGG CAGTGAATCG TCGGAATGTA GCCGGTGCTG 17340

ATGTCCAACA CGATATCGCA GCCCATCAGC AGGAGATCGG TATCCGTGGT ATGCACGTAC 17400

GCGACCGTGT TGGTATGATA GAGGTTCGCG CAGGCGTCGT CGGCCTCCAG CTGACCCGAG 17460

TTGATGTAGG CGTACCCCAG CGCCCGCAGA ACGCGGATAC AGAACAGGTG AGCCAGGCGC 17520

AGGGCCGGCT TCGAGGGCGC GCCCCAGGGG GCCGCCGGGC CTGGGCCGGC GGCCCGCGTT 17580 CCCCGGTCCC CCGGGGCGAA GGCGTGCCCG CGGCGGCGCA TGTTGGAAAA AGGCGAAACT 17640

GGGCCTGGAG TCGGTGATGG GGGAAGGCGG CGGCGAGGCG TCTACGTCAC TGGCCTCCTC 17700

GTCCGTGCGG CACTGGGCCG TCGTGCGGGC CAGGATCGCC TTGGCCCCGA ACACAACCGG 17760

CTCGGTACAC TCGACCCCGC GATCGGTCAC GAAGATGGGG AACAGGGACT TTTGGGTAAA 17820

CACCCGTAAC ATACTACAGA GACAGTGTAG CGTGATTGCC TCGCGGTCGT AACTTGGGTA 17880 GCGGCGCTGA TATTTAACCA CCAGGGTATA CATGACATTC CACAGGTCCA CGGCGATGGG 17940

GGTAAAGTAG CCCTCCGGGG CCCGGAGGCC CCGGCGCTTC ACCAGATGGT GAGTCTGGGC 18000

AAACTTCATC ATGCCAAACA GACCCATTCC GGCACGATTG TAGGTGCGGA TAGGTCTCTC 18060

TACAGAGCTG TATAGGTGTG ACGGTCCGGG ACACCCAAGC CCGCCGCCCC TGTGTACAGT 18120

GGCTGCGGCG ACGACCCCGC TCCAACAAGA CGCTATCCCG GGAAAGGCAC GCTCTTTATA 18180 ATTCTTTTTT ATTTCCCATC TACGTGCGGA TTGGTGCAAC CGCCGGCGCG CGCCGGTGCA 18240

GGCCGACCAT CTCTCTCTTC CCCCCCTCCC CCTCCCCCGA GCCCTCAAAG AGGGTGTGGC 18300

CTAACTAGCG GAAGGCGTAT TTAACCAGAC TAGGGCGGCG GGTCCGCCGT AGTCCTTGGC 18360

TCGGGTAGCC ACTGCTCTGT GGCTCGGGTC CCCCGGCCCC CCTAACCCCC ATCCGGTCCG 18420 CGTCATCCGC CCCCTCCGCC TGCGACACAA ACGGCCGCGC CTCCGGGCCC GGTGACACGA 18480

CGCGCCTCGT CTCTGCGGAT TGTCCCGGGA GCGTCGCGGC ATGGCTCATC TTCCCGGCGG 18540

TGCGGCCGCC GCCCCCCTTT CGGAGGACGC GATCCCGTCG CCGCGCGAGC GGACGGAAGA 18600

CTGGCCGCCC TGCCAGATAG TGCTGCAGGG CGCCGAGCTG AACGGGATCC TGCAGGCCTT 18660 TGCGCCGCTT CGCACGAGCC TTTTGGACTC GCTCCTGGTC GTGGGCGACC GAGGCATCCT 18720

TGTACATAAC GCGATTTTCG GCGAGCAGGT GTTTCTGCCC CTCGACCATT CGCAGTTCAG 18780

TCGCTATCGA TGGGGCGGAC CCACCGCGGC GTTCCTGTCT CTCGTGGACC AGAAGCGATC 18840

CCTGCTGAGC GTGTTTCGCG CCAACCAGTA CCCTGACCTG CGGCGGGTGG AGCTGACGGT 18900

CACGGGCCAG GCCCCGTTTC GCACGCTGGT GCAGCGCATA TGGACGACCG CGTCCGACGG 18960 AGAGGCCGTG GAGCTTGCCA GCGAGACGCT CATGAAACGC GAGTTGACGA GCTTCGCGGT 19020

ACTACTCCCC CAGGGCGACC CCGACGTCCA GCTGCGCCTC ACGAAGCCCC AGCTCACGAA 19080

GGTGGTGAAC GCCGTCGGGG ACGAGACCGC CAAACCCACC ACGTTCGAGC TCGGCCCCAA 19140

CGGCAAGTTT TCCGTGTTTA ACGCGCGCAC CTGCGTCACC TTTGCCGCCC GCGAGGAGGG 19200

CGCGTCGTCC AGCACCAGCG CCCAGGTCCA GATTCTGACC AGCGCGCTGA AGAAGGCGGG 19260 CCAGGCGGCC GCCAACGCCA AGACGGTCTA CGGGGAAAAC ACACACCGCA CATTCTCGGT 19320

GGTCGTCGAC GACTGCAGCA TGCGGGCGGT CCTCCGGCGG CTCCAGGTCG GCGGGGGGAC 19380

CCTCAAGTTC TTCCTCACGG CCGACGTCCC CAGCGTGTGT GTCACCGCCA CCGGCCCCAA 19440

CGCGGTGTCG GCGGTGTTTC TTTTAAAACC CCAGCGGGTC TGCCTGAACT GGCTCGGCCG 19500

GACCCCGGGT TCCTCGACCG GGAGCTTGGC GTCCCAGGAC TCTCGGGCCG GCCCGACCGA 19560 CAGCCAGGAC TTCTCCTCCG AGCCGGACGC GGGCGACCGC GGCGCCCCAG AAGAAGAAGG 19620

CCTCGAGGGC CAGGCCCGGG TCCCGCCCGC GTTCCCGGAA CCGCCGGGAA CCAAGCGGAG 19680

GCACGCCGGG GCCGAAGTTG TCCCCGCGGA CGACGCCACC AAGCGCCCGA AGACGGGCGT 19740

GCCCGCCGCC CCCACGCGAG CCGAGTCGCC CCCCCTCTCC GCGAGATACG GACCCGAGGC 19800

GGCGGAGGGT GGTGGGGACG GCGGCCGCTA CGCGTGCTAC TTTCGCGACC TCCAGACCGG 19860 CGACGCGAGC CCCAGCCCCC TCTCCGCCTT CCGGGGTCCC CAAAGACCCC CATACGGCTT 19920

TGGGTTGCCC TGACGGCGAC GGGTGGTGGC CGAACGCTTC ACCGCGCCCG GGCACGCGGG 19980

GTGCGTTGTG TTAAAAAAAT AAATAAATGG GGTAGTGTGT CCCCCCCCTC CAACCAATAT 20040

GGCTGTCGTG TGTGGTTCCG GGTTGCGCCT CCGTCCTTTC CACCCCCCTT CCCCCTCCTT 20100

TTTTGTTTTG CGTGCGCTTA TAAGAGCGGG CCCGGGGCCC TTCGCAGCTT CACCGAGAGC 20160 GCCGTCGGGC CCCGGGTGCG GGATGTGTCG CGGGGACAGC CCCGGGGTCG CGGGCGGGAG 20220

CGGCGAACAC TGCCTCGGAG GGGATGATGG GGACGACGGG CGCCCCCGCC TCGCCTGCGT 20280

GGGTGCCATC GCTCGGGGGT TCGCGCATCT CTGGCTCCAG GCCACCACGC TGGGCTTCGT 20340

GGGGTCTGTC GTTCTGTCGC GCGGCCCGTA TGCGGACGCC ATGTCGGGGG CGTTCGTGAT 20400

CGGGAGCACC GGCCTGGGGT TCCTCCGCGC CCCCCCCGCG TTCGCCCGGC CGCCGACGCG 20460 TGTGTGCGCG TGGCTGAGGC TGGTCGGCGG GGGAGCGGCC GTGGCCCTGT GGAGCCTCGG 20520

GGAGGCCGGC GCGCCTCCGG GGGTTCCGGG CCCGGCGACC CAGTGCCTGG CGCTCGGGGC 20580

CGCCTACGCG GCGCTGCTGG TGCTGGCCGA CGACGTCCAT CCCCTTTTCC TCCTCGCCCC 20640

GCGGCCCCTG TTTGTCGGCA CCCTGGGGGT TGTCGTCGGC GGGCTGACGA TAGGCGGCAG 20700

TGCGCGCTAC TGGTGGATCG ACCCCCGCGC CGCCGCGGCC CTGACGGCGG CGGTGGTGGC 20760 GGGCCTCGGG ACAACCGCCG CCGGGGACAG CTTTTCCAAG GCCTGTCCCC GCCACCGCCG 20820

CTTTTGCGTC GTCTCCGCGG TCGAGTCTCC CCCGCCCCGA TACGCCCCGG AGGACGCCGA 20880

GCGGCCAACA GACCACGGAC CCCTGTTACC GTCGACGCAC CACCAGCGAT CTCCGCGGGT 20940

CTGCGGCGAC GGGGCCGCAC GGCCCGAAAA CATCTGGGTT CCCGTGGTGA CCTTTGCGGG 21000 CGCGCTCGCG CTGGCCGCCT GCGCCGCGCG AGGG 21035

(2) INFORMATION FOR SEQ ID NO: 120:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1850 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 120:

Val Ala Gly Ala Ala His Met Ile Pro Ala Ala Leu Pro His Pro Thr 1 5 10 15

Met Lys Arg Gin Gly Asp Arg Asp Ile Val Val Thr Gly Val Arg Asn

20 25 30

Gin Phe Ala Thr Asp Leu Glu Pro Gly Gly Ser Val Ser Cys Met Arg 35 40 45

Ser Ser Leu Ser Phe Leu Ser Leu Leu Phe Asp Val Gly Pro Arg Asp

50 55 60

Val Leu Ser Ala Glu Ala Ile Glu Gly Cys Leu Val Glu Gly Gly Glu 65 70 75 80 Trp Thr Arg Ala Ala Ala Gly Ser Gly Pro Pro Arg Met Cys Ser Ile

85 90 95

Ile Glu Leu Pro Asn Phe Leu Glu Tyr Pro Ala Arg Gly Leu Arg Cys

100 105 110

Val Phe Ser Arg Val Tyr Gly Glu Val Gly Phe Phe Gly Glu Pro Thr 115 120 125

Ala Gly Leu Leu Glu Thr Gin Cys Pro Ala His Thr Phe Phe Ala Gly

130 135 140

Pro Trp Ala Met Arg Pro Leu Ser Tyr Thr Leu Leu Thr Ile Gly Pro 145 150 155 160 Leu Gly Met Gly Arg Asp Gly Asp Thr Ala Tyr Leu Phe Asp Pro His

165 170 175

Gly Leu Pro Ala Gly Thr Pro Ala Phe Ile Ala Lys Val Arg Ala Gly

180 185 190

Asp Val Tyr Pro Tyr Leu Thr Tyr Tyr Ala His Asp Arg Pro Lys Val 195 200 205

Arg Trp Ala Gly Ala Met Val Phe Phe Val Pro Ser Gly Pro Gly Ala

210 215 220

Val Ala Pro Ala Asp Leu Thr Ala Ala Ala Leu His Leu Tyr Gly Ala 225 230 235 240

Ser Glu Thr Tyr Leu Gin Asp Glu Pro Phe Val Glu Arg Arg Val Ala

245 - 250 255

Ile Thr His Pro Leu Arg Gly Glu Ile Gly Gly Leu Gly Ala Leu Phe 260 265 270

Val Gly Val Val Pro Arg Gly Asp Gly Glu Gly Ser Gly Pro Val Val

275 280 285

Pro Ala Leu Pro Ala Pro Thr His Val Gin Thr Pro Arg Ala Asp Arg

290 295 300 Pro Pro Glu Ala Pro Arg Gly Ala Ser Gly Pro Pro Asn Thr Pro Gin

305 310 315 320

Ala Gly His Pro Asn Arg Pro Pro Asp Asp Val Trp Ala Ala Ala Leu

325 330 335

Glu Gly Thr Pro Pro Ala Lys Pro Ser Ala Pro Asp Ala Ala Ala Ser 340 345 350

Gly Pro Pro His Ala Ala Pro Pro Pro Gin Thr Pro Ala Gly Asp Ala

355 360 365

Ala Glu Glu Ala Glu Asp Leu Arg Val Leu Glu Val Gly Ala Val Pro

370 375 380 Val Gly Arg His Arg Ala Arg Tyr Ser Thr Gly Leu Pro Lys Arg Arg

385 390 395 400

Arg Pro Thr Trp Thr Pro Pro Ser Ser Val Glu Asp Leu Thr Ser Gly

405 410 415

Glu Arg Pro Ala Pro Lys Ala Pro Pro Ala Lys Ala Lys Lys Lys Ser 420 425 430

Ala Pro Lys Lys Lys Ala Pro Val Ala Ala Glu Val Pro Ala Ser Ser

435 440 445

Pro Thr Pro Ile Ala Ala Thr Val Pro Pro Ala Pro Asp Thr Pro Pro

450 455 460 Gin Ser Gly Gin Gly Gly Gly Asp Asp Gly Pro Asp Ser Ser Pro Ser

465 470 475 480

Val Leu Glu Thr Leu Gly Ala Arg Arg Pro Pro Glu Pro Pro Gly Ala

485 490 495

Asp Leu Ala Gin Leu Phe Glu Val His Pro Asn Val Ala Ala Thr Ala 500 505 510

Val Arg Leu Ala Ala Arg Asp Ala Ala Arg Glu Val Ala Ala Cys Ser

515 520 525

Gin Leu Thr Ile Asn Ala Leu Arg Ser Pro Tyr Pro Ala His Pro Gly 530 535 540 Leu Leu Glu Leu Cys Val Ile Phe Phe Phe Glu Arg Val Leu Ala Phe 545 550 555 560

Leu Ile Glu Asn Gly Ala Arg Thr His Thr Gin Ala Gly Val Ala Gly 565 570 575 Pro Ala Ala Ala Leu Leu Asp Phe Thr Leu Arg Met Leu Pro Arg Lys

580 585 590

Thr Ala Val Gly Asp Phe Leu Ala Ser Thr Arg Met Ser Leu Ala Asp 595 600 605 Val Ala Ala His Arg Pro Leu Ile Gin His Val Leu Asp Glu Asn Ser 610 615 620

Gin Ile Gly Arg Leu Ala Lys Leu Val Leu Val Ala Arg Asp Val Ile 625 630 635 640

Arg Glu Thr Asp Ala Phe Tyr Gly Asp Leu Ala Asp Leu Asp Leu Gin 645 650 655

Leu Arg Ala Ala Pro Pro Ala Asn Leu Tyr Ala Arg Leu Gly Glu Trp

660 665 670

Leu Leu Glu Arg Ser Arg Ala His Pro Asn Thr Leu Phe Ala Pro Ala 675 680 685 Thr Pro Thr His Pro Glu Pro Leu Leu His Arg Ile Gin Ala Gin Phe 690 695 700

Arg Glu Glu Met Arg Val Glu Ala Glu Ala Arg Glu Met Arg Glu Ala 705 710 715 720

Leu Asp Arg Val Asp Ser Val Ser Gin Arg Ala Gly Pro Leu Thr Val 725 730 735

Met Pro Val Pro Ala Ala Pro Gly Ala Gly Gly Arg Ala Pro Cys Pro

740 745 750

Pro Ala Leu Gly Pro Glu Ala Ile Gin Ala Arg Leu Glu Asp Val Arg 755 760 765 Ile Gin Ala Arg Arg Ala Ile Glu Ser Ala Ile Lys Glu Tyr Phe His 770 775 780

Arg Gly Ala Val Tyr Ser Ala Lys Ala Leu Gin Ala Ser Asp Ser His 785 790 795 800

Asp Cys Arg Phe His Val Ala Ser Ala Ala Val Val Pro Met Val Gin 805 810 815

Leu Leu Glu Ser Leu Pro Ala Phe Asp Gin His Thr Arg Asp Val Ala

820 825 830

Gin Arg Ala Ala Leu Pro Pro Pro Pro Pro Leu Ala Thr Ser Pro Gin 835 840 845 Ala Ile Leu Leu Arg Asp Leu Leu Gin Arg Gly Gin Thr Leu Asp Ala 850 855 860

Pro Glu Asp Leu Ala Ala Trp Leu Ser Val Leu Thr Asp Ala Ala Thr 865 870 875 880

Gin Gly Leu Ile Glu Arg Lys Pro Leu Glu Glu Leu Ala Arg Ser Ile 885 890 895

His Gly Ile Asn Asp Gin Gin Ala Arg Arg Ser Ser Gly Leu Ala Glu

900 905 910

Leu Gin Arg Phe Asp Ala Leu Asp Ala Ala Gin Gin Leu Asp Ser Asp 915 920 925

Ala Ala Phe Val Pro Ala Thr Gly Pro Ala Pro Tyr Val Asp Gly Gly

930 935 - 940

Gly Leu Ser Pro Glu Ala Thr Arg Met Ala Glu Asp Ala Leu Arg Gin 945 950 955 960

Ala Arg Ala Met Glu Ala Ala Lys Met Thr Ala Glu Leu Ala Pro Glu

965 970 975

Ala Arg Ser Arg Leu Arg Glu Arg Ala His Ala Leu Glu Ala Met Leu 980 985 990 Asn Asp Ala Arg Glu Arg Ala Lys Val Ala His Asp Ala Arg Glu Lys 995 1000 1005

Phe Leu His Lys Leu Gin Gly Val Leu Arg Pro Leu Pro Asp Phe Val

1010 1015 1020

Gly Leu Lys Ala Cys Pro Ala Val Leu Ala Thr Leu Arg Ala Ser Leu 1025 1030 1035 104

Pro Ala Gly Trp Thr Asp Leu Ala Asp Ala Val Arg Gly Pro Pro Pro

1045 1050 1055

Glu Val Thr Ala Ala Leu Arg Ala Asp Leu Trp Gly Leu Leu Gly Gin 1060 1065 1070 Tyr Arg Glu Ala Leu Glu His Pro Thr Pro Asp Thr Ala Thr Ala Gly 1075 1080 1085

Leu His Pro Ala Phe Val Val Val Leu Lys Thr Leu Phe Ala Asp Ala

1090 1095 1100

Pro Glu Thr Pro Val Leu Val Gin Phe Phe Ser Asp His Ala Pro Thr 1105 1110 1115 112

Ile Ala Lys Ala Val Ser Asn Ala Ile Asn Ala Gly Ser Ala Ala Val

1125 1130 1135

Ala Thr Asp Ala Ala Thr Val Asp Ala Ala Val Arg Ala His Gly Ala 1140 1145 1150 Asp Ala Val Ser Ala Leu Gly Ala Ala Ala Arg Asp Pro Asp Leu Ser 1155 1160 1165

Phe Leu Ala Ala Asp Ser Ala Ala Gly Tyr Val Lys Ala Thr Arg Leu

1170 1175 1180

Ala Leu Glu Arg Ala Ile Asp Glu Leu Thr Thr Leu Gly Ser Ala Ala 1185 1190 1195 120

Ala Asp Leu Val Val Gin Ala Arg Arg Ala Cys Ala Gin Pro Glu Gly

1205 1210 1215

Asp His Ala Ala Leu Ile Asp Ala Ala Ala Arg Ala Thr Thr Ala Ala 1220 1225 1230 Arg Glu Ser Leu Ala Gly His Glu Ala Gly Phe Gly Gly Leu Leu His 1235 1240 1245

Ala Glu Gly Thr Ala Gly Asp His Ser Pro Ser Gly Arg Ala Leu Gin 1250 1255 1260 Glu Leu Gly Lys Val Ile Gly Ala Thr Arg Arg Arg Ala Asp Glu Leu

1265 1270 1275 128

Glu Ala Ala Val Ala Asp Leu Thr Ala Lys Met Ala Ala Gin Arg Arg

1285 1290 1295 Ser Ser Trp Ala Ala Gly Val Glu Ala Ala Leu Asp Arg Val Glu Asn

1300 1305 1310

Arg Ala Glu Phe Asp Val Val Glu Leu Arg Arg Leu Gin Ala Gly Thr

1315 1320 1325

His Gly Tyr Asn Pro Arg Asp Phe Arg Lys Arg Ala Glu Gin Ala Ala 1330 1335 1340

Asn Ala Glu Ala Val Thr Leu Ala Leu Asp Thr Ala Phe Ala Phe Asn

1345 1350 1355 136

Pro Tyr Thr Pro Glu Asn Gin Arg His Pro Met Leu Pro Pro Leu Ala

1365 1370 1375 Ala Ile His Arg Leu Gly Trp Ser Ala Ala Phe His Ala Ala Ala Glu

1380 1385 1390

Thr Tyr Ala Asp Met Phe Arg Val Asp Ala Glu Pro Leu Ala Arg Leu

1395 1400 1405

Leu Arg Ile Ala Glu Gly Leu Leu Glu Met Ala Gin Ala Gly Asp Gly 1410 1415 1420

Phe Ile Asp Tyr His Glu Ala Val Gly Arg Leu Ala Asp Asp Met Thr

1425 1430 1435 144

Ser Val Pro Gly Leu Arg Arg Tyr Val Pro Phe Phe Gin His Gly Tyr

1445 1450 1455 Ala Asp Tyr Val Glu Leu Arg Asp Arg Leu Asp Ala Ile Arg Ala Asp

1460 1465 1470

Val His Arg Ala Leu Gly Gly Val Pro Leu Asp Leu Ala Ala Ala Ala

1475 1480 1485

Glu Gin Ile Ser Ala Ala Arg Asn Asp Pro Glu Ala Thr Ala Glu Leu 1490 1495 1500

Val Arg Thr Gly Val Thr Leu Pro Cys Pro Ser Glu Asp Ala Leu Val

1505 1510 1515 152

Ala Cys Ala Ala Ala Leu Glu Arg Val Asp Gin Ser Pro Val Lys Asn

1525 1530 1535 Thr Ala Tyr Ala Glu Tyr Val Ala Phe Val Thr Arg Gin Asp Thr Ala

1540 1545 1550

Glu Thr Lys Asp Ala Val Val Arg Ala Lys Gin Gin Arg Ala Glu Ala

1555 1560 1565

Thr Glu Arg Val Met Ala Gly Leu Arg Glu Ala Ala Arg Glu Arg Arg 1570 1575 1580

Ala Gin Ile Glu Ala Glu Gly Leu Ala Asn Leu Lys Thr Met Leu Lys 1585 1590 1595 160

Val Val Ala Val Pro Ala Thr Val Ala Lys Thr Leu Asp Gin Ala Arg 1605 1610 1615

Ser Val Ala Glu Ile Ala Asp Gin Val Glu Val Leu Leu Asp Gin Thr

1620 - 1625 1630

Glu Lys Thr Arg Glu Leu Asp Val Pro Ala Val Ile Trp Leu Glu His 1635 1640 1645

Ala Gin Arg Thr Phe Glu Thr His Pro Leu Ser Ala Arg Asp Gly Pro

1650 1655 1660

Gly Pro Leu Ala Arg His Ala Gly Arg Leu Gly Ala Leu Phe Asp Thr 1665 1670 1675 168 Arg Arg Arg Val Asp Ala Leu Arg Arg Ser Leu Glu Glu Ala Glu Ala

1685 1690 1695

Glu Trp Asp Glu Val Trp Gly Arg Phe Gly Arg Val Arg Gly Gly Ala

1700 1705 1710

Trp Lys Ser Pro Glu Gly Phe Arg Ala Met His Glu Gin Leu Arg Ala 1715 1720 1725

Leu Gin Asp Thr Thr Asn Thr Val Ser Gly Leu Arg Ala Gin Pro Ala

1730 1735 1740

Tyr Glu Arg Leu Ser Ala Arg Tyr Gin Gly Val Leu Gly Ala Lys Gly 1745 1750 1755 176 Ala Glu Arg Ala Glu Ala Val Glu Glu Leu Gly Ala Arg Val Thr Lys

1765 1770 1775

His Thr Ala Leu Cys Ala Arg Leu Arg Asp Glu Val Val Arg Arg Val

1780 1785 1790

Pro Trp Glu Met Asn Phe Asp Ala Leu Gly Arg Leu Leu Ala Glu Phe 1795 1800 1805

Asp Ala Ala Ala Ala Asp Leu Ala Pro Trp Ala Val Glu Glu Phe Arg

1810 1815 1820

Gly Ala Arg Glu Leu Ile Gin Tyr Arg Met Gly Ser Ala Tyr Ala Arg 1825 1830 1835 184 Ala Gly Gly Gin Thr Xaa Xaa Xaa Xaa Xaa

1845 1850

(2) INFORMATION FOR SEQ ID NO: 121:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1100 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 121: Met Ser Asp Ser Ala Leu Gin Val Pro Ala Pro Ala Gly Met Thr Pro

1 5 - 10 15

Pro Ser Ala Pro Pro Pro Asn Gly Pro Leu Gin Val Leu Leu Gly Ser 20 25 30

Leu Thr Asn Leu Arg Arg Pro Pro Ser Pro Ser Ser Glu Pro Ala Gly

35 40 45

Ser Ala Asp Glu Pro Ala Phe Leu Ser Ala Ala Lys Leu Arg Ala Ala 50 55 60 Thr Ala Ala Phe Leu Leu Ser Gly Ala Ala Val Gly Pro Ala Glu Ala 65 70 75 80

Arg Ala Cys Trp His Pro Leu Leu Glu Gin Leu Cys Ala Leu His Arg

85 90 95

Ala His Gly Leu Pro Glu Thr Ala Leu Leu Ala Glu Asn Leu Pro Gly 100 105 110

Leu Leu Val His Arg Met Ala Val Pro Glu Thr Pro Glu Ala Ala Phe

115 120 125

Arg Glu Met Asp Val Ile Lys Asp Thr Val Leu Ala Ile Thr Gly Ser

130 135 140 Asp Thr Thr His Ala Leu Glu Ala Ala Gly Leu Arg Thr Thr Ala Ala

145 150 155 160

Leu Gly Pro Val Arg Val Arg Gin Cys Ala Val Glu Trp Ile Asp Arg

165 170 175

Trp Arg Thr Val Thr Gin Ser Cys Leu Ala Met Asn Pro Arg Thr Ser 180 185 190

Leu Glu Ala Leu Gly Glu Met Ser Leu Lys Met Ser Pro Val Pro Leu

195 200 205

Gly Gin Pro Gly Ala Asn Leu Thr Thr Pro Ala Tyr Ser Leu Leu Phe

210 215 220 Pro Ser Pro Ile Val Gin Glu Gly Leu Arg Phe Leu Ala Leu Val Ser

225 230 235 240

Asn Trp Val Thr Leu Phe Ser Ala His Leu Gin Arg Ile Asp Asp Ala

245 250 255

Ala Leu Thr Pro Leu Thr Arg Ala Leu Phe Thr Leu Ala Leu Val Asp 260 265 270

Glu Tyr Leu Thr Thr Pro Asp Arg Gly Ala Val Val Pro Pro Pro Leu

275 280 285

Leu Ala Gin Phe Gin His Thr Val Arg Glu Ile Asp Pro Ala Ile Met 290 295 300 Ile Pro Pro Leu Glu Ala Thr Lys Met Val Arg Ser Arg Glu Glu Val 305 310 315 320

Arg Val Ser Thr Ala Leu Ser Arg Val Ser Pro Arg Ser Ala Cys Ala 325 330 335 Pro Pro Gly Thr Leu Met Ala Arg Val Arg Thr Asp Ala Ala Val Phe

340 345 350

Asp Pro Asp Val Pro Phe Leu Ser Ala Ser Ala Ile Phe Arg Pro Ala 355 360 365 Val Thr Gly Leu Leu Gin Leu Gly Glu Pro Pro Ser Ala Gly Ala Gin 370 375 380

Gin Arg Leu Leu Ala Leu Leu Gin Gin Thr Trp Ala Leu Val Gin Asn 385 390 395 400

Ser Asn Ser Pro Ser Val Val Ile Asn Thr Leu Thr Asp Ala Gly Phe 405 410 415

Thr Pro Ala His Cys Thr Gin Tyr Ile Ser Ala Leu Glu Gly Phe Leu

420 425 430

Val Ala Gly Val Pro Ala Arg Thr Pro Pro Gly His Gly Leu Ser Glu 435 440 445 lie Gin Gin Leu Phe Gly Cys Ile Ala Gly Ala Asn Val Phe Gly Leu 450 455 460

Ala Arg Glu Tyr Gly His Tyr Ala Gly Tyr Val Lys Thr Phe Arg Arg 465 470 475 480 lie Gin Gly Ala Ser Glu His Thr His Gly Arg Leu Cys Glu Ala Val 485 490 495

Gly Leu Ser Gly Gly Val Leu Ser Gin Thr Leu Ala Arg Ile Met Gly

500 505 510

Pro Ala Val Pro Thr Glu His Leu Ala Ser Leu Arg Arg Thr Leu Val 515 520 525 Gly Glu Phe Glu Thr Ala Glu Arg Arg Phe Ser Ala Gly Gin Pro Ser 530 535 540

Leu Leu Arg Glu Thr Ala Leu Ile Trp Leu Asp Val Tyr Gly Gin Thr 545 550 555 560

His Trp Asp Leu Thr Pro Thr Thr Pro Ala Thr Pro Leu Ser Ala Leu 565 570 575

Leu Pro Val Gly Pro Pro Ser His Ala Pro Ser Val His Leu Ala Ala

580 585 590

Ala Thr Lys Ile Arg Phe Pro Ala Leu Glu Gly Ile His Pro Asn Val 595 600 605 Leu Ala Asp Pro Gly Phe Val Pro Tyr Val Leu Ala Leu Val Val Gly 610 615 620

Asp Ala Leu Arg Ala Thr Cys Asn Ala Ala Tyr Leu Pro Arg Pro Ile 625 630 635 640

Glu Phe Ala Leu Arg Val Leu Ala Trp Ala Arg Asp Phe Gly Leu Gly 645 650 655

Tyr Leu Pro Thr Val Glu Gly His Arg Thr Lys Leu Gly Ala Leu Ile

660 665 670

Thr Leu Leu Glu Pro Ala Thr Arg Ala Gly Val Gly Pro Thr Met Gin 675 680 685

Met Ala Asp Asn Ile Glu Gin Leu Leu Arg Glu Leu Tyr Val Ile Arg

690 695 - 700

Ala Val Glu Gin Leu Arg Pro Ala Val Gin Leu Pro Pro Pro Gin Pro 705 710 715 720

Pro Glu Val Gly Ser Ser Leu Leu Leu Ile Ser Met Tyr Ala Arg Val

725 730 735

Leu Gin Glu Leu Ala Glu Arg Ala Asp Pro Leu Val Arg Gin Leu Glu 740 745 750 Asp Ala Ile Val Leu Leu Arg Leu His Met Arg Thr Leu Ala Ala Phe 755 760 765

Phe Glu Cys Arg Phe Glu Ser Asp Gly His Arg Leu Tyr Ala Val Val

770 775 780

Ala Asp Ala His Glu Arg Leu Gly Pro Trp Arg Pro Glu Ala Met Gly 785 790 795 800

Asp Ala Val Ser Gin Tyr Cys Gly Met Tyr His Asp Ala Lys Arg Ala

805 810 815

Leu Val Ala Ser Leu Ala Gly Leu Arg Ser Val Val Thr Glu Thr Thr 820 825 830 Ala His Leu Gly Val Cys Asp Glu Leu Ala Ala Gin Val Ser His Glu 835 840 845

Gly Asn Val Leu Ala Val Val Arg Arg Glu Ile His Gly Phe Leu Ala

850 855 860

Ile Val Ser Gly Ile His Ala Arg Ala Ser Lys Leu Met Ser Gly Asp 865 870 875 880

Gin Val Pro Gly Phe Cys Tyr Met Ser Gin Phe Leu Ala Arg Trp Arg

885 890 895

Arg Leu Ser Ala Gly Tyr Gin Ala Ala Arg Ala Ala Thr Gly Pro Glu 900 905 910 Arg Val Ala Glu Phe Val Gin Glu Leu His Asp Thr Trp Lys Gly Leu 915 920 925

Gin Thr Glu Arg Ala Leu Val Val Ala Pro Phe Ala Ser Ser Ala Asp

930 935 940

Gin Arg Thr Ala Ala lie Gin Glu Val Met Ala His Ala Thr Glu Asp 945 950 955 960

Ala Pro Pro Ser Pro Ala Ala Asp Leu Val Val Leu Thr Asn Arg His

965 970 975

Asp Leu Gly Ala Trp Gly Asp Tyr Ser Leu Gly Pro Leu Gly Gin Pro 980 985 990 Thr Val Val Pro Asp Ser Val Asp Leu Ser Pro Gin Gly Leu Ala Ala 995 1000 1005

Thr Leu Ser Met Asp Trp Leu Leu Ile Asn Glu Leu Leu Gin Val Thr 1010 1015 1020 Asp Gly Val Phe Arg Ala Ser Ala Phe Arg Pro Ser Ala Gly Pro Glu

1025 1030 1035 104

Ala Pro Gly Asp Leu Glu Ala Gin Asp Ala Gly Gly Ser Thr Pro Glu

1045 1050 1055 Pro Thr Thr Pro Gly Pro Gin Asp Thr Gin Ala Arg Ala Pro Ser Trp

1060 1065 1070

Ala Gly Arg Glu Thr Val Pro Trp Pro Asn Thr Pro Val Glu Asp Asp

1075 1080 1085

Glu Met Thr Pro Gin Glu Thr Pro Pro Val His Pro 1090 1095 1100

(2) INFORMATION FOR SEQ ID NO: 122:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 641 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:122:

Val Glu Arg Thr Gly Gly Ser Cys Arg Arg Ala Pro Gly Pro Gly Ala 1 5 10 15

Arg Cys Pro Thr Trp Arg Pro Ala Cys Ala Leu Gly Asp Ala Ala Arg

20 25 30

Arg Pro Arg Ala Gin Thr Gly Met Thr Ala Ala Ala Leu Tyr Gly Gly 35 40 45 Ala Lys Tyr Arg Pro Gly Thr Leu Arg Asn Pro Gly Arg Val Ala Ser 50 55 60

Thr Pro Arg Arg Arg Gly Val Leu Tyr Gly Ala Leu Cys Pro Gly Ile 65 70 75 80

Pro Phe Val Gly Ser Gly Pro Gly Ala Val Gly Trp Glu Cys Val Cys 85 90 95

Val Gly Gly Gly Arg Arg Asp Gly Gly Pro Asp Gin Val Tyr Arg Gly

100 105 110

Arg Ser Val Gly Arg Pro Asn Arg Pro Phe Lys His Leu Arg Met His 115 120 125 Arg Pro Ser Gin Ser Asp Thr Gly Thr His Gin Arg Arg Lys Pro Pro 130 135 140

Ser Pro Val Arg Val Arg Val Phe Ser Gly Gly Val Phe Phe Leu Ser 145 150 155 160 Ala Leu Leu Pro Pro His Leu His His Pro Pro Pro Thr Trp Leu Ala

165 170 175

Ile Gly Gly Lys Thr Met Lys Thr Lys Pro Leu Pro Thr Ala Pro Met 180 185 190 Ala Trp Ala Glu Ser Ala Val Glu Thr Thr Thr Ser Pro Arg Glu Leu 195 200 205

Ala Gly His Ala Pro Leu Arg Arg Val Leu Arg Pro Pro Ile Ala Arg

210 215 220

Arg Asp Gly Pro Val Leu Leu Gly Asp Arg Ala Pro Arg Arg Thr Ala 225 230 235 240

Ser Thr Met Trp Leu Leu Gly Ile Asp Pro Ala Glu Ser Ser Pro Gly

245 250 255

Thr Arg Ala Thr Arg Asp Asp Thr Glu Gin Ala Val Asp Lys Ile Leu 260 265 270 Arg Gly Ala Arg Arg Ala Gly Gly Leu Thr Val Pro Gly Ala Pro Arg 275 280 285

Tyr His Leu Thr Arg Gin Val Thr Leu Thr Asp Leu Cys Gin Pro Asn

290 295 300

Ala Glu Arg Ala Gly Ala Leu Leu Leu Ala Leu Arg His Pro Thr Asp 305 310 315 320

Leu Pro His Leu Ala Arg His Arg Ala Pro Pro Gly Arg Gin Thr Glu

325 330 335

Arg Leu Ala Glu Ala Trp Gly Gin Leu Leu Glu Ala Ser Ala Leu Gly 340 345 350 Ser Gly Arg Ala Glu Ser Gly Cys Ala Arg Ala Gly Leu Val Ser Phe 355 360 365

Asn Phe Leu Val Ala Ala Cys Ala Ala Ala Tyr Asp Ala Arg Asp Ala

370 375 380

Ala Glu Ala Val Arg Ala His Ile Thr Thr Asn Tyr Gly Gly Thr Arg 385 390 395 400

Ala Gly Ala Arg Leu Asp Arg Phe Ser Glu Cys Leu Arg Ala Met Val

405 410 415

His Thr His Val Phe Phe Val Met Arg Phe Phe Gly Gly Leu Val Ser 420 425 430 Trp Val Thr Gin Asp Glu Leu Ala Ser Val Thr Ala Val Cys Ser Gly 435 440 445

Pro Gin Glu Ala Thr His Thr Gly His Pro Gly Arg Pro Cys Ser Ala

450 455 460

Val Thr Ile Pro Ala Cys Ala Phe Val Asp Leu Asp Ala Glu Leu Cys 465 470 475 480

Leu Gly Gly Pro Gly Ala Ala Phe Leu Tyr Leu Val Phe Tyr Gin Cys

485 490 495

Arg Asp Gin Glu Leu Cys Cys Val Tyr Val Val Lys Ser Gin Leu Pro 500 505 510

Pro Arg Gly Leu Glu Ala Ala Leu Glu Arg Leu Phe Gly Arg Leu Arg

515 520 525

Ile Thr Asn Thr Ile His Gly Ala Glu Asp Met Thr Pro Pro Pro Pro 530 535 540

Asn Arg Asn Val Asp Phe Pro Leu Ala Val Leu Ala Ala Ser Ser Gin

545 550 555 560

Ser Pro Arg Cys Ser Ala Ser Gin Val Thr Asn Pro Gin Phe Val Asp

565 570 575 Arg Leu Tyr Arg Trp Gin Pro Asp Leu Arg Gly Arg Pro Thr Ala Arg

580 585 590

Thr Cys Thr Tyr Ala Ala Phe Ala Glu Leu Gly Val Met Pro Asp Asn

595 600 605

Ser Pro Arg Cys Leu His Arg Thr Glu Arg Phe Gly Ala Val Gly Val 610 615 620

Pro Val Val Ile Gly Val Val Trp Arg Pro Gly Gly Trp Arg Ala Cys 625 630 635 640

Ala

(2) INFORMATION FOR SEQ ID NO: 123:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1160 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 123

Val Ile Arg Arg Pro Val Arg Pro Phe Gly Arg Thr Ala His Pro Ala 1 5 10 15 Ser His Gly Pro Ala Ala Val Ser Val His Arg Val Arg Ala Thr Val 20 25 30

Thr Leu Val Pro Met Ala Asn Arg Pro Ala Ala Ser Ala Gly Ala Arg

35 40 45

Ser Pro Ser Gin Glu Pro Arg Glu Pro Glu Val Ala Pro Pro Gly Gly 50 55 60

Asp His Val Phe Cys Arg Lys Val Ser Gly Val Met Val Leu Ser Ser 65 70 75 80

Asp Pro Pro Gly Pro Ala Ala Tyr Arg Ile Ser Asp Ser Ser Phe Val 85 90 95

Gin Cys Gly Ser Asn Cys Ser Met Ile Ile Asp Gly Asp Val Arg His

100 " 105 110

Leu Arg Asp Leu Glu Gly Ala Thr Ser Thr Gly Ala Phe Val Ala Ile 115 120 125

Ser Asn Val Ala Ala Gly Gly Asp Gly Arg Thr Ala Val Val Gly Gly

130 135 140

Thr Ser Gly Pro Ser Ala Thr Thr Ser Val Gly Thr Gin Thr Ser Gly 145 150 155 160 Glu Phe Leu His Gly Asn Pro Arg Thr Pro Glu Pro Gin Gly Pro Gin

165 170 175

Ala Val Pro Pro Pro Pro Pro Pro Pro Phe Pro Trp Gly His Glu Cys

180 185 190

Cys Ala Arg Arg Asp Arg Gly Ala Glu Lys Asp Val Gly Ala Ala Glu 195 200 205

Ser Trp Ser Asp Gly Pro Ser Ser Asp Ser Glu Thr Glu Asp Ser Asp

210 215 220

Ser Ser Asp Glu Asp Thr Gly Ser Gly Ser Glu Thr Leu Ser Arg Ser 225 230 235 240 Ser Ser Ile Trp Ala Ala Gly Ala Thr Asp Asp Asp Asp Ser Asp Ser

245 250 255

Asp Ser Arg Ser Asp Asp Ser Val Gin Pro Asp Val Val Val Arg Arg

260 265 270

Arg Trp Ser Asp Gly Pro Ala Pro Val Ala Phe Pro Lys Pro Arg Arg 275 280 285

Pro Gly Asp Ser Pro Gly Asn Pro Gly Leu Gly Ala Gly Thr Gly Pro

290 295 300

Gly Ser Ala Thr Asp Pro Arg Ala Ser Ala Asp Ser Asp Ser Ala Ala 305 310 315 320 His Ala Ala Ala Pro Gin Ala Asp Val Ala Pro Val Leu Asp Ser Gin

325 330 335

Pro Thr Val Gly Thr Asp Pro Gly Tyr Pro Val Pro Leu Glu Leu Thr

340 345 350

Pro Glu Asn Ala Glu Ala Val Ala Arg Phe Leu Gly Asp Ala Val Asp 355 360 365

Arg Glu Pro Ala Leu Met Leu Glu Tyr Phe Cys Arg Cys Ala Arg Glu

370 375 380

Glu Ser Lys Arg Val Pro Pro Arg Thr Phe Gly Ser Ala Pro Arg Leu 385 390 395 400 Thr Glu Asp Asp Phe Gly Leu Leu Asn Tyr Ala Glu Met Arg Arg Leu

405 410 415

Cys Leu Asp Leu Pro Pro Val Pro Pro Asn Ala Tyr Thr Pro Tyr His 420 425 430 Leu Arg Glu Tyr Ala Thr Arg Leu Val Asn Gly Phe Lys Pro Leu Val

435 440 445

Arg Arg Ser Ala Arg Leu Tyr Arg Ile Leu Gly lie Leu Val His Leu

450 455 460 Arg Ile Arg Thr Arg Glu Ala Ser Phe Glu Glu Trp Met Arg Ser Lys

465 470 475 480

Glu Val Asp Leu Asp Phe Gly Leu Thr Glu Arg Leu Arg Glu His Glu

485 490 495

Ala Gin Leu Met Ile Leu Ala Gin Ala Leu Asn Pro Tyr Asp Cys Leu 500 505 510

Ile His Ser Thr Pro Asn Thr Leu Val Glu Arg Gly Leu Gin Ser Ala

515 520 525

Leu Lys Tyr Glu Glu Phe Tyr Leu Lys Arg Phe Gly Gly His Tyr Met

530 535 540 Glu Ser Val Phe Gin Met Tyr Thr Arg Ile Ala Gly Phe Leu Ala Cys

545 550 555 560

Arg Ala Thr Arg Gly Met Arg His Ile Ala Leu Gly Arg Gin Gly Ser

565 570 575

Trp Trp Glu Met Phe Lys Phe Phe Phe His Arg Leu Tyr Asp His Gin 580 585 590

Ile Val Pro Ser Thr Pro Ala Met Leu Asn Leu Gly Thr Arg Asn Tyr

595 600 605

Tyr Thr Ser Ser Cys Tyr Leu Val Asn Pro Gin Ala Thr Thr Asn Gin

610 615 620 Ala Thr Leu Arg Ala Ile Thr Gly Asn Val Ser Ala Ile Leu Ala Arg

625 630 635 640

Asn Gly Gly Ile Gly Leu Cys Met Gin Ala Phe Asn Asp Asp Gly Thr

645 650 655

Ala Ser Ile Met Pro Ala Leu Lys Val Leu Asp Ser Leu Val Ala Ala 660 665 670

His Asn Lys Gin Ser Trp Thr Gly Ala Cys Val Tyr Leu Glu Pro Trp

675 680 685

His Ser Asp Val Arg Ala Val Leu Arg Met Lys Gly Val Leu Ala Gly

690 695 700 Glu Glu Ala Gin Arg Cys Asp Asn Ile Phe Ser Ala Leu Trp Met Pro

705 710 715 720

Asp Leu Phe Phe Lys Arg Leu Ile Arg His Leu Asp Gly Glu Lys Asn

725 730 735

Val Thr Trp Ser Leu Phe Asp Arg Asp Thr Ser Met Ser Leu Ala Asp 740 745 750

Phe His Gly Glu Glu Phe Glu Lys Leu Tyr Glu His Leu Glu Ala Met

755 760 765

Gly Phe Gly Glu Thr Ile Pro Ile Gin Asp Leu Ala Tyr Ala Ile Val 770 775 780

Arg Ser Ala Ala Thr Thr Gly Ser Pro Phe Ile Met Phe Lys Asp Ala 785 790 ^" 795 800

Val Asn Arg His Tyr Ile Tyr Asp Thr Gin Gly Ala Ala Ile Ala Gly 805 810 815

Ser Asn Leu Cys Thr Glu Ile Val His Pro Ser Ser Lys Arg Ser Ser

820 825 830

Gly Val Cys Asn Leu Gly Ser Val Asn Leu Ala Arg Cys Val Ser Arg 835 840 845 Arg Thr Phe Asp Phe Gly Met Leu Arg Asp Ala Val Gin Ala Cys Val 850 855 860

Leu Met Val Asn Ile Met Ile Asp Ser Thr Leu Gin Pro Thr Pro Gin 865 870 875 880

Cys Arg His Asp Asn Leu Arg Ser Met Gly Ile Gly Met Gin Gly Leu 885 890 895

His Thr Ala Cys Leu Lys Met Gly Leu Asp Leu Glu Ser Ala Glu Phe

900 905 910

Arg Asp Leu Asn Thr His Ile Ala Glu Val Met Leu Leu Ala Ala Met 915 920 925 Lys Thr Ser Asn Ala Leu Cys Val Arg Gly Ala Arg Pro Phe Ser His 930 935 940

Phe Lys Arg Ser Met Tyr Arg Ala Gly Arg Phe His Trp Glu Arg Phe 945 950 955 960

Ser Asn Asp Arg Tyr Glu Gly Glu Trp Glu Met Leu Arg Gin Ser Met 965 970 975

Met Lys His Gly Leu Arg Asn Ser Gin Phe Ile Ala Leu Met Pro Thr

980 985 990

Ala Ala Ser Ala Gin Ile Ser Asp Val Ser Glu Gly Phe Ala Pro Leu 995 1000 1005 Phe Thr Asn Leu Phe Ser Lys Val Thr Arg Asp Gly Glu Thr Leu Arg 1010 1015 1020

Pro Asn Thr Leu Leu Leu Lys Glu Leu Glu Arg Thr Phe Gly Gly Lys 1025 1030 1035 104

Arg Leu Leu Asp Ala Met Asp Gly Leu Glu Ala Lys Gin Trp Ser Val 1045 1050 1055

Ala Gin Ala Leu Pro Cys Leu Asp Pro Ala His Pro Leu Arg Arg Phe

1060 1065 1070

Lys Thr Ala Phe Asp Tyr Asp Gin Glu Leu Leu Ile Asp Leu Cys Ala 1075 1080 1085 Asp Arg Ala Pro Tyr Val Asp His Ser Gin Ser Met Thr Leu Tyr Val 1090 1095 1100

Thr Glu Lys Ala Asp Gly Thr Leu Pro Ala Ser Thr Leu Val Arg Leu 1105 1110 1115 112 Leu Val His Ala Tyr Lys Arg Gly Leu Lys Thr Gly Met Tyr Tyr Cys

1125 1130 1135

Lys Val Arg Lys Ala Thr Asn Ser Gly Val Phe Ala Gly Asp Asp Asn 1140 1145 1150 Ile Val Cys Thr Ser Cys Ala Leu 1155 1160

(2) INFORMATION FOR SEQ ID NO: 124:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 333 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 124:

Met Asp Pro Ala Val Ser Pro Ala Ser Thr Asp Pro Leu Asp Thr His 1 5 10 15

Ala Ser Gly Ala Gly Ala Ala Pro Ile Pro Val Cys Pro Thr Pro Glu

20 25 30

Arg Tyr Phe Tyr Thr Ser Gin Cys Pro Asp Ile Asn His Leu Arg Ser 35 40 45

Leu Ser Ile Leu Asn Arg Trp Leu Glu Thr Glu Leu Val Phe Val Gly

50 55 60

Asp Glu Glu Asp Val Ser Lys Leu Ser Glu Gly Glu Leu Gly Phe Tyr 65 70 75 80 Arg Phe Leu Phe Ala Phe Leu Ser Ala Ala Asp Asp Leu Val Thr Glu

85 90 95

Asn Leu Gly Gly Leu Ser Gly Leu Phe Glu Gin Lys Asp Ile Leu His

100 105 110

Tyr Tyr Val Glu Gin Glu Cys Ile Glu Val Val His Ser Arg Val Tyr 115 120 125

Asn Ile Ile Gin Leu Val Leu Phe His Asn Asn Asp Gin Ala Arg Arg

130 135 140

Ala Tyr Val Ala Arg Thr Ile Asn His Pro Ala Ile Arg Val Lys Val 145 150 155 160 Asp Trp Leu Glu Ala Arg Val Arg Glu Cys Asp Ser Ile Pro Glu Lys

165 170 175

Phe Ile Leu Met Ile Leu Ile Glu Gly Val Phe Phe Ala Ala Ser Phe 180 185 190 Ala Ala Ile Ala Tyr Leu Arg Thr Asn Asn Leu Leu Arg Val Thr Cys

195 200 205

Gin Ser Asn Asp Leu Ile Ser Arg Asp Glu Ala Val His Thr Thr Ala

210 215 220 Ser Cys Tyr Ile Tyr Asn Asn Tyr Leu Gly Gly His Ala Lys Pro Glu

225 230 235 240

Ala Ala Arg Val Tyr Arg Leu Phe Arg Glu Ala Val Asp Ile Glu Ile

245 250 255

Gly Phe Ile Arg Ser Gin Ala Pro Thr Asp Ser Ser Ile Leu Ser Pro 260 265 270

Gly Ala Ala Ile Glu Asn Tyr Val Arg Phe Ser Ala Asp Arg Leu Leu

275 280 285

Gly Leu Ile His Met Gin Pro Lys Ala Pro Ala Pro Asp Ala Ser Phe 290 295 300 Pro Leu Ser Leu Met Ser Thr Asp Lys His Thr Asn Phe Phe Glu Cys 305 310 315 320

Arg Ser Thr Ser Tyr Ala Gly Ala Val Val Asn Asp Leu 325 330

(2) INFORMATION FOR SEQ ID NO: 125:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 357 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 125:

Met Arg Arg Arg Gly His Ala Phe Ala Pro Gly Asp Arg Gly Thr Arg

1 5 10 15

Ala Ala Gly Pro Gly Pro Ala Ala Pro Trp Gly Ala Pro Ser Lys Pro 20 25 30

Ala Leu Arg Leu Ala His Leu Phe Cys Ile Arg Val Leu Arg Ala Leu

35 40 45

Gly Tyr Ala Tyr Ile Asn Ser Gly Gin Leu Glu Ala Asp Asp Ala Cys 50 55 60 Ala Asn Leu Tyr His Thr Asn Thr Val Ala Tyr Val His Thr Thr Asp 65 70 75 80

Thr Asp Leu Leu Leu Met Gly Cys Asp Ile Val Leu Asp Ile Ser Thr 85 90 95 Gly Tyr Ile Pro Thr Ile His Cys Arg Asp Leu Leu Gin Tyr Phe Lys

100 105 110

Met Ser Tyr Pro Gin Phe Leu Ala Leu Phe Val Arg Cys His Thr Asp 115 120 125 Leu His Pro Asn Asn Thr Tyr Ala Ser Val Glu Asp Val Leu Arg Glu 130 135 140

Cys His Trp Thr Ala Pro Ser Arg Ser Gin Ala Arg Arg Ala Ala Arg 145 150 155 160

Arg Glu Arg Ala Asn Ser Arg Ser Leu Glu Ser Met Pro Thr Leu Thr 165 170 175

Ala Ala Pro Val Gly Leu Glu Thr Arg Ile Ser Trp Thr Glu Ile Leu

180 185 190

Ala Gin Gin Ile Ala Gly Glu Asp Asp Tyr Glu Glu Asp Pro Pro Leu 195 200 205 Gin Pro Pro Asp Val Ala Gly Gly Pro Arg Asp Gly Ala Arg Ser Ser 210 215 220

Ser Ser Glu Ile Leu Thr Pro Pro Glu Leu Val Gin Val Pro Asn Ala 225 230 235 240

Gin Arg Val Ala Glu His Arg Gly Tyr Val Ala Gly Arg Arg Arg His 245 250 255

Val Ile His Asp Ala Pro Glu Ala Leu Asp Trp Leu Pro Asp Pro Met

260 265 270

Thr Ile Ala Glu Leu Val Glu His Arg Tyr Val Lys Tyr Val Ile Ser 275 280 285 Leu Ile Ser Pro Lys Glu Arg Gly Pro Trp Thr Leu Leu Lys Arg Leu 290 295 300

Pro Ile Tyr Gin Asp Leu Arg Asp Glu Asp Leu Ala Arg Ser Ile Val 305 310 315 320

Thr Arg His Ile Thr Ala Pro Asp Ile Ala Asp Arg Phe Leu Ala Gin 325 330 335

Leu Trp Ala His Ala Pro Pro Pro Ala Phe Tyr Lys Asp Val Leu Ala

340 345 350

Lys Phe Trp Asp Glu 355

(2) INFORMATION FOR SEQ ID NO: 126:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 466 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 126:

Met Ala His Leu Pro Gly Gly Ala Ala Ala Ala Pro Leu Ser Glu Asp 1 5 10 15

Ala Ile Pro Ser Pro Arg Glu Arg Thr Glu Asp Trp Pro Pro Cys Gin

20 25 30

Ile Val Leu Gin Gly Ala Glu Leu Asn Gly Ile Leu Gin Ala Phe Ala 35 40 45

Pro Leu Arg Thr Ser Leu Leu Asp Ser Leu Leu Val Val Gly Asp Arg

50 55 60

Gly Ile Leu Val His Asn Ala Ile Phe Gly Glu Gin Val Phe Leu Pro 65 70 75 80 Leu Asp His Ser Gin Phe Ser Arg Tyr Arg Trp Gly Gly Pro Thr Ala

85 90 95

Ala Phe Leu Ser Leu Val Asp Gin Lys Arg Ser Leu Leu Ser Val Phe

100 105 110

Arg Ala Asn Gin Tyr Pro Asp Leu Arg Arg Val Glu Leu Thr Val Thr 115 120 125

Gly Gin Ala Pro Phe Arg Thr Leu Val Gin Arg Ile Trp Thr Thr Ala

130 135 140

Ser Asp Gly Glu Ala Val Glu Leu Ala Ser Glu Thr Leu Met Lys Arg 145 150 155 160 Glu Leu Thr Ser Phe Ala Val Leu Leu Pro Gin Gly Asp Pro Asp Val

165 170 175

Gin Leu Arg Leu Thr Lys Pro Gin Leu Thr Lys Val Val Asn Ala Val

180 185 190

Gly Asp Glu Thr Ala Lys Pro Thr Thr Phe Glu Leu Gly Pro Asn Gly 195 200 205

Lys Phe Ser Val Phe Asn Ala Arg Thr Cys Val Thr Phe Ala Ala Arg

210 215 220

Glu Glu Gly Ala Ser Ser Ser Thr Ser Ala Gin Val Gin Ile Leu Thr 225 230 235 240 Ser Ala Leu Lys Lys Ala Gly Gin Ala Ala Ala Asn Ala Lys Thr Val

245 250 255

Tyr Gly Glu Asn Thr Thr Phe Ser Val Val Val Asp Asp Cys Ser Met

260 265 270

Arg Ala Val Leu Arg Arg Leu Gin Val Gly Gly Gly Thr Leu Lys Phe 275 280 285

Phe Leu Thr Ala Asp Val Pro Ser Val Cys Val Thr Ala Thr Gly Pro

290 295 300

Asn Ala Val Ser Ala Val Phe Leu Leu Lys Pro Gin Arg Val Cys Leu 305 310 315 320

Asn Trp Leu Gly Arg Thr Pro Gly Ser Ser Thr Gly Ser Leu Ala Ser

325 " 330 335

Gin Asp Ser Arg Ala Gly Pro Thr Asp Ser Gin Asp Phe Ser Ser Glu 340 345 350

Pro Asp Ala Gly Asp Arg Gly Ala Pro Glu Glu Glu Gly Leu Glu Gly

355 360 365

Gin Ala Arg Val Pro Pro Ala Phe Pro Glu Pro Pro Gly Thr Lys Arg

370 375 380 Arg His Ala Gly Ala Glu Val Val Pro Ala Asp Asp Ala Thr Lys Arg

385 390 395 400

Pro Lys Thr Gly Val Pro Ala Ala Pro Thr Arg Ala Glu Ser Pro Pro

405 410 415

Leu Ser Ala Arg Tyr Gly Pro Glu Ala Ala Glu Gly Gly Gly Asp Gly 420 425 430

Gly Arg Tyr Ala Cys Tyr Phe Arg Asp Leu Gin Thr Gly Asp Asp Ser

435 440 445

Pro Leu Ser Ala Phe Arg Gly Pro Gin Arg Pro Pro Tyr Gly Phe Gly 450 455 460 Leu Pro 465

(2) INFORMATION FOR SEQ ID NO: 127:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 331 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 127:

Val Cys Pro Pro Pro Pro Thr Asn Met Ala Val Val Cys Gly Ser Gly

1 5 10 15

Leu Arg Leu Arg Pro Phe His Pro Pro Ser Pro Ser Phe Phe Val Leu

20 25 30

Arg Ala Leu Ile Arg Ala Gly Pro Gly Pro Phe Ala Asp Arg Ala Pro 35 40 45

Ser Gly Pro Gly Cys Gly Met Cys Arg Gly Asp Ser Pro Gly Val Ala

50 55 60

Gly Gly Ser Gly Glu His Cys Leu Gly Gly Asp Asp Gly Asp Asp Gly 65 70 75 80

Arg Pro Arg Leu Ala Cys Val Gly Ala Ile Arg Phe Ala His Leu Trp

85 - 90 95

Leu Gin Ala Thr Thr Leu Gly Phe Val Gly Ser Val Val Leu Ser Arg 100 105 110

Gly Pro Tyr Ala Asp Ala Met Ser Gly Ala Phe Val Ile Gly Ser Thr

115 120 125

Gly Leu Gly Phe Leu Arg Ala Pro Pro Ala Phe Ala Arg Pro Pro Thr

130 135 140 Arg Val Cys Ala Trp Leu Arg Leu Val Gly Gly Gly Ala Ala Val Trp

145 150 155 160

Ser Leu Gly Glu Ala Gly Ala Pro Pro Gly Val Pro Gly Pro Ala Thr

165 170 175

Gin Cys Leu Ala Leu Gly Ala Ala Tyr Ala Ala Leu Leu Val Leu Ala 180 185 190

Asp Asp Val His Pro Leu Phe Leu Leu Ala Pro Arg Pro Leu Phe Val

195 200 205

Gly Thr Leu Gly Val Val Val Gly Gly Leu Thr Ile Gly Gly Ser Ala

210 215 220 Arg Tyr Trp Trp Ile Asp Pro Arg Ala Ala Ala Ala Leu Thr Ala Ala

225 230 235 240

Val Val Ala Gly Leu Gly Thr Thr Ala Ala Gly Asp Ser Phe Ser Lys

245 250 255

Ala Cys Pro Arg His Arg Arg Phe Cys Val Val Ser Ala Val Glu Ser 260 265 270

Pro Pro Pro Arg Tyr Ala Pro Glu Asp Ala Glu Arg Pro Thr Asp His

275 280 285

Gly Pro Leu Leu Pro Ser Thr His His Gin Arg Ser Pro Arg Val Cys 290 295 300 Gly Asp Gly Ala Ala Arg Pro Glu Asn Ile Trp Val Pro Val Val Thr 305 310 315 320

Phe Ala Gly Ala Leu Ala Ala Cys Ala Arg Ser 325 330

(2) INFORMATION FOR SEQ ID NO: 128:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2342 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 128:

GGCGGGATCT GCGCACGCGC GGCACGGCGG CGGAGAAAGC GGCGGCAGAG CCGGAAAAGG 60

CCGGGGGAGG AAGCGCGGCA TCCGCGGGGG GACTCGGTGT GGGTGGCGAG GGCCGTGGGT 120 CGTCGCGAGG GGCCACGGGC ACGCGCCCCG TGTTTTGTTG AGGCGGGACA CTCGGTCGTG 180

TTTCGCGAGC CGTAGCTGCC GGCCCGATGG GCCGCGGTGC GTACTGGGAC GTGGGGACGG 240

ACTGATCGGT GGCGGGGGGG GGAAGAAGGG CCGGGGCCGG ATTGGGCGTG GGGCCGCCGG 300

CGTCGTCGGA CGCCAGCTCC TCCAGGCCGT GGATCCAGGC CCACATGCGA GGGGGGACGG 360

GCTCGCCGGT GGTGGCGTCG GTGAGGAGAG TGGGGGCGAG GACCCCCGGG TCCGCCTGCC 420 GCGCGGGGGG GGCAGCGGGG TCCTCGGGAC CCGATCCGCC ATCCCCCCCC GCAAGGTCCC 480

GCGGGTCGCG GGCGGCGGTC GGGGCAGAGG GACCTGCCTC GTCGGCGAGG GGGCGCTGGT 540

AAACCGGGTG TCCCGGGAAC AGCTCCCCCG TCAGGAGGGA GGCGTCGAAG GGCCGCCCGA 600

GGATGGCCCG CGCGAAGAAG GGGTCCGCGT CGGCGGCGCT CGCCGCGAGA ACGTCCCCCG 660

CGGTAGCCAC AAACGGAAGC TCCTCGGTGG CCTCGCTGCC CACAAACCGC ACGTCAGGGG 720 GGCCGGGGGG CTCCGGGGCT TCCCACAAGA CCGCGACCGG GGTCATGGAG ATGTCCACGA 780

GGACCAGGCA CGGGGGCCCG TCGGCGAGAG GGCGCTCGGC GATGAGCGCC GACAGGCGCG 840

GGAGCTGCGC CGCCAGACAC GCGTTTTCGA TCGGGTTGAG ATCGGTGTGG AGGAGGCCGA 900

CGGCCCACGT CTCGATGTCG GACGACACGA CGTCGCGCAG GGCGGCGTCC GGCCCGCCGG 960

GGCGCGAGTC GAAGAGCGTC AGGCACAGTT CCAGTTCCGA CTCGCGGGAG AAGGCCGTGG 1020 TGTTGCGGAG CGCCACCACG ACGGGCGCGC CGAGGAGCAC CGCGGCCAGA ACCAGGTCCA 1080

TGGCCGTAAC GCGCGCGGCG GGGGTGCGGT GGGTCGCGGC GGCCAGCACG GCCACGTGCT 1140

GGCCCGTGGG TCGGTAGAGG GCGTGGGGGG CCTCGGGGAG GGACGCCTCG CGCCCCCCCG 1200

CCGGGCCGAG CGTCTGGCCA GACTCCAGGC GTGCGGCCAG GAGGGCGTCG AAGCTGTCGT 1260

ACTCGGTGTA GTCGTCGGGA AACATGCAGG TCCACAGCGC GGCCAAAGCG GCGCTCGGCA 1320 GACACATGCG CCCGAGGACG CTCACCGCCG CCAGGGCCTG GGCCGGACTG AGCTTCCCGA 1380

GCGCCGGGGC GTCCCGGCGC TGGGTCCCGA GCTCCAAGGC CGAGCGCCAG GGCGCCAGCG 1440

GGTCGGTTTC GGACAGCTTG CCCCGGCGCC AGTCGGCCAG CCGCGTGCCG AACAGGAGGC 1500

CCCGGGTCGG GGGGCCTCCG TCCAAAAACG TCGGCAACAC GCGGATGCGG GCGTCGGGAT 1560

GCGGGGTCAG GCGCTGGACG AACAGCATGG ACTCCGCTGC GTCCTCGAAC GCGCGTTCGA 1620 GGGTGAGGTG CATGTACTCG TGCTGGCGAA CGAGGTCCAG GCGCCAGAAG TTGTAGATGT 1680

GTTCCGGAAC GCCGGCCACC AGCGCGACCA GCACGTCGTT CTCGTTGAAG GCGACGCAGT 1740

GGCGCTGGGA CCCCCGGGGG CCCGGCGGCG GACGCGGCGC CGCCGCTCCG GACGCCCAGC 1800

CCAGCTGGGC CCAGCGACAC CCAAACTCGC GCGTGAGGGT GGTGGCGACG AGGGCGACGT 1860

ACAGCTCGGC CGCCGCGTCC ATCGAGGCGC CCCACGTCGC CTGGCGATGG CGCACGAAGC 1920 GACCGAACAG CTGAAAGTTG GCGGCCTGGG CGTCGCTGAG GGCCAGCTGG AGCCGGTTCA 1980

CGACGGTCAG CACGTACATG GCCGTGACCG TCGGGGCCGA TTCGAGGACG TCCGTCGGAA 2040

GCGGGGGCCG CACGCAGGCC GCCTCGGGAC GCATCAGCAG CGCGCCGAGT TTGTCGGTGA 2100

CGGCCGGGAA GCATAGCGCG TACTGCAGCG GCGTTCCGTC CGGGGCCAAA AAGCTGGTGG 2160

CGAACGGCAG ATCCAGAGCG CTGACGGCCT CACGCAGCAC CAGGGGCCCC GGGTCTCCGC 2220 CGGCGCGCAG ATACGCCTCG CCCCGGCGGC GCAGCAGCTG CGGGTCGACC TCGTGGCCCT 2280

CGGGGGAAGA AGAGGCCCGG GCGCGGGCGT CGAGGGCGCG AAGATCAACG AGCAGGGGCG 2340

C 2342 ( 2 ) INFORMATION FOR SEQ ID NO : 129 :

( i ) SEQUENCE CHARACTERISTICS : (A) LENGTH : 771 amino acids ( B ) TYPE : amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 129:

Ala Pro Leu Leu Val Asp Leu Arg Ala Leu Asp Ala Arg Ala Arg Ala 1 5 10 15 Ser Ser Ser Pro Glu Gly His Glu Val Asp Pro Gin Leu Leu Arg Arg 20 25 30

Arg Gly Glu Ala Tyr Leu Arg Ala Gly Gly Asp Pro Gly Pro Leu Val

35 40 45

Leu Arg Glu Ala Val Ser Ala Leu Asp Leu Pro Phe Ala Thr Ser Phe 50 55 60

Leu Ala Pro Asp Gly Thr Pro Leu Gin Tyr Ala Leu Cys Phe Pro Ala 65 70 75 80

Val Thr Asp Lys Leu Gly Ala Leu Leu Met Arg Pro Glu Ala Ala Cys 85 90 95 Val Arg Pro Pro Leu Pro Thr Asp Val Leu Glu Ser Ala Pro Thr Val 100 105 110

Thr Ala Met Tyr Val Leu Thr Val Val Asn Arg Leu Gin Leu Ala Leu

115 120 125

Ser Asp Ala Gin Ala Ala Asn Phe Gin Leu Phe Gly Arg Phe Val Arg 130 135 140

His Arg Gin Ala Thr Trp Gly Ala Ser Met Asp Ala Ala Ala Glu Leu

145 150 155 160

Tyr Val Val Ala Thr Thr Leu Thr Arg Glu Phe Gly Cys Arg Trp Ala

165 170 175 Gin Leu Gly Trp Ala Ser Gly Ala Ala Ala Pro Arg Pro Pro Pro Gly

180 185 190

Pro Arg Gly Ser Gin Arg His Cys Val Ala Phe Asn Glu Asn Asp Val

195 200 205

Leu Val Val Ala Gly Val Pro Glu His Ile Tyr Asn Phe Trp Arg Leu 210 215 220

Asp Leu Val Arg Gin His Glu Tyr Met His Leu Thr Leu Glu Arg Ala 225 230 235 240

Phe Glu Asp Ala Ala Glu Ser Met Leu Phe Val Gin Arg Leu Thr Pro 245 250 255

His Pro Asp Ala Arg Ile Arg Val Leu Pro Thr Phe Leu Asp Gly Gly 260 265 270

Pro Pro Thr Arg Gly Leu Leu Phe Gly Thr Arg Leu Ala Asp Trp Arg 275 280 285

Arg Gly Lys Leu Ser Glu Thr Asp Pro Leu Ala Pro Trp Arg Ser Ala 290 295 300

Leu Glu Leu Gly Thr Gin Arg Arg Asp Ala Pro Ala Leu Gly Lys Leu

305 310 315 320

Ser Pro Ala Gin Ala Ala Val Ser Val Leu Gly Arg Met Cys Leu Pro 325 330 335

Ser Ala Ala Ala Leu Trp Thr Cys Met Phe Pro Asp Asp Tyr Thr Glu 340 345 350

Tyr Asp Ser Phe Asp Ala Leu Leu Ala Ala Arg Leu Glu Ser Gly Gin 355 360 365

Thr Leu Gly Pro Ala Gly Gly Arg Glu Ala Ser Leu Pro Glu Ala Pro 370 375 380

His Ala Leu Tyr Arg Pro Thr Gly Gin His Val Ala Val Leu Ala Ala

385 390 395 400

Ala Thr Thr Pro Ala Ala Arg Val Thr Ala Met Asp Leu Val Leu Ala 405 410 415

Ala Val Leu Leu Gly Ala Pro Val Val Val Arg Asn Thr Thr Ala Phe 420 425 430

Ser Arg Glu Ser Glu Leu Glu Leu Cys Leu Thr Leu Phe Asp Ser Arg 435 440 445

Pro Gly Gly Pro Asp Ala Ala Leu Arg Asp Val Val Ser Ser Asp Ile

450 455 460

Glu Thr Trp Ala Val Gly Leu Leu His Thr Asp Leu Asn Pro Ile Glu

465 470 475 480

Asn Ala Cys Leu Ala Ala Gin Leu Pro Arg Leu Ser Ala Leu Ile Ala 485 490 495

Glu Arg Pro Leu Ala Asp Gly Pro Pro Cys Leu Val Leu Val Asp Ile 500 505 510

Ser Met Thr Pro Val Ala Val Leu Trp Glu Ala Pro Glu Pro Pro Gly 515 520 525

Pro Pro Asp Val Arg Phe Val Gly Ser Glu Ala Thr Glu Glu Leu Pro 530 535 540

Phe Val Ala Thr Ala Gly Asp Val Leu Ala Ala Ser Ala Ala Asp Ala

545 550 555 560

Asp Pro Phe Phe Ala Arg Ala Ile Leu Gly Arg Pro Phe Asp Ala Ser

565 570 575

Leu Leu Thr Gly Glu Leu Phe Pro Gly His Pro Val Tyr Gin Arg Pro 580 585 590 Leu Ala Asp Glu Ala Gly Pro Ser Ala Pro Thr Ala Ala Arg Asp Pro

595 600 605

Arg Asp Leu Ala Gly Gly Asp Gly Gly Ser Gly Pro Glu Asp Pro Ala

610 615 620 Ala Pro Pro Ala Arg Gin Ala Asp Pro Gly Val Leu Ala Pro Thr Leu

625 630 635 640

Leu Thr Asp Ala Thr Thr Gly Glu Pro Val Pro Pro Arg Met Trp Ala

645 650 655

Trp Ile His Gly Leu Glu Glu Leu Ala Ser Asp Asp Ala Gly Gly Pro 660 665 670

Thr Pro Asn Pro Ala Pro Ala Leu Leu Pro Pro Pro Ala Thr Asp Gin

675 680 685

Ser Val Pro Thr Ser Gin Tyr Ala Pro Arg Pro Ile Gly Pro Ala Ala

690 695 700 Thr Ala Arg Glu Trp Ser Val Pro Pro Gin Gin Asn Thr Gly Arg Val

705 710 715 720

Pro Val Ala Pro Arg Asp Asp Pro Arg Pro Ser Pro Pro Thr Pro Ser

725 730 735

Pro Pro Ala Asp Ala Ala Leu Pro Pro Pro Ala Phe Ser Gly Ser Ala 740 745 750

Ala Ala Phe Ser Ala Ala Val Pro Arg Val Arg Arg Ser Arg Xaa Xaa

755 760 765

Xaa Xaa Xaa 770

(2) INFORMATION FOR SEQ ID NO: 130:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14927 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 130:

GCACGTCAGC GGCGGCCCGC GTCGCGATGT CGCCCCAGCT CTCCGGCCCC TGCGCCCCTG 60

GCTCGGGGCC GCGCTCCCCG TCCTCGCTCG CGGGCGTCCC CGCGCCACGC CTCCGCCCCC 120

CCTCCTCCGC GGCGGCCCGG GGCTCTTCCT CCTCGGCCCC CCCGGTCGCG CCGCCGGCCC 180 CCAGCCGCGC CAGCACGCGG CGCAGCGCCT CCTCGTCGCA CTGCTCGGGG CTGACGAGCC 240

GCCGCAGCAG CGGCGTCGTC AGGTGGTGGT CGTAGCACGC GCGTATCAGC GCCTCGATCT 300

GATCGTCGGG CGACGTCGCC TGGCCGCCGA TGATCAGGGC GTCCACCATG TCCAGCGCCG 360

CCAGGTGGCC CCCGAACGCG CGATCGAAGT GCTCCGCCCG CCGCCCGAAC AGCGCCAGCT 420 CCACGGCCAC CGCGGCGGTC TCCTGCTGCA GCTCGCGCTG CGCCAGCGCG TTCAGGTTGT 480

CGGCGAAGGC GTCCATGGTG GAGTGGCGGG CGCGATCGCC GGACGCCAGC CAGAAGCGCA 540

GCTCGCTGAT GGCGTACAGG CCGGGCGTAG TGGCCTGAAA CACGTCATGC GCCTCCAGCA 600

GGGCGTCGGC CTCCTCGCGG ACAGAAGAGC TATCGGCGGG CGGCGGGCCG GCCCGGGCCC 660 CGCCGCCCGC CGCGGTCCGC GCCAGCGCCT GGTCCAGCAC ACAGAGCGCT CGCGCGCGGG 720

CGGCGTCCGA CAGCCCGGCG GCGTGGGGCA GGTACCGTCG CAGCTCGTTG GCGTCCAGCC 780

GCACCTGGGC CTGTTGGGTG ACGTGGTTAC AGATGCGGTC CGCCAGGCGG CGGGCGATGG 840

TCGCCCCCTG GTTCGCGGTG ACGCACAGCT CCTCGAAACA GACCGCGCAC GGGTGGGACG 900

GGTCGCTCAG CTCCGGGGGC ACGATGAGGC CCGACCCCAC CGCCGCCACC ATAAACTCCC 960 GGACGCGCTC CAGCGCGGCC GTGGCGCCGC TCGGGGGGGT GATGAGGTGG CAGTAGTTCA 1020

GCTGCTTGAG AAAATTCTCG ACATCATGCA GGAAGCACAG CTCCATGCGG ACGTCCCCGC 1080

CGTACGTCTC CAGCCGGATC TGCTGGTGGT ACGGACAGGG TCGGGCCAGA CCCATGGTCT 1140

CGGTGAAAAA GGCAGAGACG TCACCCGTGG TCGCGAACGT TTCCAGGTGG CCCAGGAGCC 1200

GCTCCCCCTC GCGCCACGCG TACTCCAGGA GCAACTCCAG GGTGACCGAC AGCGGGGTGA 1260 GAAAGGCGGC GGCCTGAGCC TCCAGCCCCG GCCGCAGGTG CCGCCGCAGC ACGCGCACCT 1320

GGAGCGCGTT GAGCTTTAGC TGGGCGAGCT TCCCCAGGCC GATCTGGGGG TCGCATCGTC 1380

GAAGCAGCTC TAGCTGAAAA ACGTACGTCT GTACCTGCCC GAGCAGGGCC AACAGTTTCT 1440

GTCGGGCCGC AGTGGGCTCG GAAACCGCGG CCGGGGGCGC GGCCGCCATG GCGAGTCGCC 1500

CGGCCGTGCT GTGGTTTAGT TAAGGTTTGG GGGGGTGGGT CAGAGGCGCG CCCCGCGCGG 1560 ACTGATGCGG CGGCGGGCCC CTGACATCCC CTCTTTATGC CCGTCGCCCG CCCGCCCGCC 1620

CCGCCGGTGT GCCGTGATTC GCGGAGTCGG GGCCTTGTGT TTCTTTCTTT CCCCCCCCGA 1680

ATCCGTTCTT TCTTCCTCAC CCCCCCTCCC CACACACCCA CCCAGGACTC GCCACCACAA 1740

GGAGGCGAGA GCCCGTCGCT AACCCAAAGA CACAGTCACG AGACACGATA TCGACTGTAG 1800

TTGCGATCGT TTATTTTATA CACAACACCA ACCTTTCCTT CGACCCCCCC CACCCCCGCC 1860 CCTAGAGCAT ATCCAACGTC AGGTCCTTTT TCTCCGGTGG TCCCTCCCCA AACGGATCGT 1920

CGCCGTGAAA CGCCCGCTTT CGGGCGACGC CGGCCGCCCC CGCCGCCGCC GCCAAACCGC 1980

CGAACGACGC CGCGTGGTCA TCCTCGTCGC CGAAATCCCC AAAGTTAAAC ACCTCCCCGG 2040

CGGCGCCGAG CTGGCTGACC AGGGCCTCCG CCTCGTGGGC CACCTCCAGG GCCGCGTCGG 2100

TCGACCACTC GCCGTGCCCG CGCTCCAGGG CGCGGGTGGT AAACTCCATC ATTTCCTCGC 2160 TCAGGTACTC GTCCTCCAGC AGCGCCAGCC AGTCCTCGAT CTGCAGCTGC TGGGTGCGGG 2220

GGCCCAGGCT CTTGACGGTC GCCACAAACA CGCTGCTGGC GACCGCCGCC CCGCCCTCCG 2280

CAATGATGCC CCGGAGCTGC TCGCACAGCG AATGCTCGTG GGCCCCGCCC CCGAGACTCG 2340

ACGCCGCGCA CACAAACCCG GCCCTGGGGC AGGCCAGGAC AAACTTGCGG GTGCGGTCAA 2400

AGATCAGCAG CGGGCACGCG TTTTTGCCGC CCAGCAGGCT GGCCCAGTTC CCGGCCTGAA 2460 ACACGCGGTC GTTGCCGGCC ATGCCGTAGT ATTTGCTGAT GCTGAGGCCC AGCACGACCA 2520

TCGGGCGCGC GGCCATCACG GGCCGCAGCA GGTTGCAGCT CGCGAACATG GACGTCCAGG 2580

CGCCGGGGTG CGCGTCGAGG GAGTCCATCA GCGCGCGGGC CCCGGCCTCC AGGCCCGCGC 2640

CGCCCTGCGG GGCCCAGGCG GCGGCCGCCT GCACGCCGGG GGGACGGCGG GACCCGGCGA 2700

TGACGGCCGT GAGGGTGTTT ATGAAGTACG TCGAGTGGTC GCAGTACCTC AAGATCTGGT 2760 TGGCCATGTA GTACATGGCC AGTTCGCTCA CGTTATTGGG GGCCAGGTTG ATAAAGTTAA 2820

TCGCGCCGTA GTCCAGGGAG AACCTCTTAA TGAACGCGAT GGTCTCTATG TCCTCGCGCG 2880

ACAAGAGCCG GGCGGGGAGC TGGTTGCGCT GGAGGGCGGT CCAGAACCAC TGCGGGTTCG 2940

GCTGGTTCGA CCCCGGGGGC TTGCCGTTGG GAAAGATGAC CGCGTGGAAC TGCTTCAGCA 3000 GGAAGCCCAG CGGTCCGAGG AGGATGTCCA CGCGCTTGTC GGGCTTCTGG TAGGCGCTCT 3060

GGAGGCTGGC GACCCGCGCC TTGGCGGCCT CGGACGCGTT GGCGCTCGCG CCCGCGAACA 3120

ACACGCGGCT CTTGACGCGC AGCTCCTTGG GAAACCCCAG GGTCACGCGG GCAACGTCGC 3180

CCTCGAAGCT GCTCTCGGCG GGGGCCGTCT GGCCGGCCGT TAGGCTGGGG GCGCAGATAG 3240 CCGCCCCCTC CGAGAGCGCG ACCGTCAGCG TCTTCGCCGA CAGGAACCCG TTGTTGAACA 3300

GGTCCATGAC GCGCCGCCGC AGCACCGGTT GGAATTGATT GCGAAAGTTG CGCCCCTCGA 3360

CCGACTGCCC GGCGAACACC CCGTGGCACT GGCTCAGGGC CAGGTCCTGG TACACGGCGA 3420

GGTTGGACCG CCGCGCGAGG AGCTGCAGCA GGGGGCACGG CCCGCAGGTG TACGGGTCCA 3480

GCGACAGCGA CATGGCGTGG TTGGCCTCGG CCAGACCGTC GCGGAACTTA AAGTTGCGCC 3540 CCTCGATCAG GTTGCGCATC AGCTGTTCCA CCTCGCGATC CACCAGCTGC TTGATGTTGT 3600

TCACCACCGT GTGCAGGGCC TCGCGGGTGC CGATAATCGT CTCCAGCCTC CCCAGGGCCG 3660

TGGGCACCGC CTGGTCCACG TACTGCAGGG CCTCGAGCTC GGCCATGACG CGCTCGGTGG 3720

CCGCGCGGTA CGTCTCCTGC ATGATGGTCC GGGTGTTCTC GGACCCGTCC GCGCGCTTCA 3780

GGGCCGAGAA GGCGGCGTAG TTCCCCAGCA CGTCGCAGTC GCTGTACGCG CTGTTCATCG 3840 TTCCGAAGAC CCCAATGGCC CCCCGGGCGG CGCTCGCGAA CTTGGGGTGG CGGGCCCGCA 3900

GCCGCATCAG CGTCGTGTGC GCGCAGGCGT GGCGGGTCTC GAAGGTACAC AGGTTGCAGG 3960

GCACGTCGGT CTGGCCCGAG TCCGCGACGT AGCGAAACAC GTCCATCTCC TGGCGCCCGA 4020

CGATGACTCC GCCGTCGCAG CGCTCCAGGT AAAACAGCAT CTTGGCCAGC AGGGCCGGAG 4080

AGAACCCGCA CAGCATGGCC AGGTGCTCGC CGGCGAACTC CTGGGTTCCG CCGACGAGGG 4140 GCGCCGTGGG GCGCCCCTCG TACCCGGGCA CCACGTGGCC CTCGCGGTCC AGCTGCGGGT 4200

TGGCCGCCAC GTGCGTGCCG GGCACGAGAA AGAAGCGGTA AAAGGAGGGC TTGCTGTGGT 4260

CCTTGGGGTC CGCCGGCCCG GCGTCGTCCA CCTCGGTCAG GTGGAGGGCC GAGTTGGTGC 4320

TGAACACCAT GGCGCCCACG AGGCCCGCGG CGCGCGCCAG GTACGCCCCG ACGGCGCCGG 4380

CACGGGCCGC GGGCGTTTCC TGGCCCTCAA GCAGGGGCCA CGTGGTGATG TCGGGGGGCG 4440 GCTCGTCAAA GACCGCCATC GACACGATGG ACTCCAGGGC CAGGGCGGCG TCGCCCGCCA 4500

TCACCGAGGC CAGGCGCTGC TCAAACCCGC CCGCCGGGCC CTTGTTCCCG GCGTCGCGCG 4560

CGCCCCGCTG GGGCTTACCC TGGCTGGCCT CGAAGGCCGT GAACGTAATG TCGGCGGGGA 4620

GGGCCGCGCC CTCGTGGTTT TCGTCGAACG CCAGGTGGGC GGCCGCGCGG GCCACGGCGT 4680

CCACGTTCCG AGCACGCAGG GCCACGGCGG CGGGCCCGAC GACCGCCTCG AACAGCAGGC 4740 GGGCGAGGGG GCGGTTGAAA AACGGAAGGG GGTAGTTGAA ATTCTCCCCG ATCGATCGGT 4800

GGTTGCAGTT AAACGGATCG GCGATGACCC GGCTAAAATC CGGCATAAAC ATCTGCAGCG 4860

GATACACGGG GATGCGGTGA ACCTCCGCGT CCCCGATGGT TACCTTGTCC ATCCCGCCCA 4920

GGTGCAGGAA GGTGTTGCTG ATGCACACGG CCTCCCGGAA GCCCTCCGTG ATCACCAGAT 4980

ACAGCAAGGC CCGGTCCGGG TCCAGTCCGA GCCGCTCGCA CAGCGCGTCC CCCGTCGTCT 5040 CGTGCTTTAG GTCGCAGGGC CGGGGCGCGT AGTCCGAGAA GCCAAAATGG CGGCGCGCCC 5100

GCTCGCAGAG CCGCGTCAGG TTGGGGGCCT GGGTGCTGGG GGCCAGGTGG CGGCCGCCGT 5160

GAAAGACGTA GACGGACGGG CTGTAGTGCG AGGGCATAAG CTTGAGGGAC ACCGCGGTCC 5220

CCCCAAGGCC CGTCGTGCGG GACCCGACGA CCGCGGCCAC GTTGGCCTCA AACCCGCTCT 5280

CCACGGTCAG GCCGACGATG AGGGGCGCGA CGGCGACGTC CGCGTCGCCG CTGCGCGCCG 5340 ACAGTAGCGA CAGCAGCTCC AGGCCTTCGG CCGGACAGGC GCGGCCATAC ACGTACCCCA 5400

TCGGCCCCGG AGGAACCTTG ACGGTGGTCG TCGTTTTGGG CTTGGTGTCC ATGGCTTTCG 5460

GGAGATTGGC GACCGGCAGG AACGGGGGCC CGGCAAGACG ACCGGGGGCA GACGGGGGAG 5520

GCCGCGCGTG GTCGACGGCT GCTGCCCGCC GTCGTCTCTC CGATGGGGTC GAATGCCGGC 5580 GCTGGGGGTG GGGTCTACAC CCGCCCGTTC ACCGAGCGGC CCCTGGTGGG GGTGGGATGG 5640

GTGGGATGGG GTGGGCGAGA ATGGCCCGCC ACCGGATCGC GCCGGACGGG GGGGCCCGGG 5700

GTTGGGCAAG GTTTGGGCGC AAGGCTCCAG CGGCGATTCG AGAGGCCTGC GGATGGCGGC 5760

CCAGAGCTGG GTATGCTCGG CCGGGGCGGC CGGTATATGT ACGGCGTGCT GGGAGGGGCG 5820 GCGTCGGGCC CCGCCCACGG TCCGCCACGC CCCGCGCGTC ATCGGCAGGG GGCGTGGCCG 5880

CCCTTCTAAA AAAAGTGAGA ACGCGAAGCG TTCGCACTTT GTCCTAATAG TATATATATT 5940

ATTAGGACAA AGTGCGAACG CTTCGCGTTC TCACTTTTTT TAGAAGGGCG GCCACGCCCC 6000

CTTTGACGTC ACGCTCACCC GGGCGGCCGG CCGCCCATAA GCGCGGCCTG CCGGGCCGAT 6060

AAAAAGAAAC CGCGGCGCCC CCGCGGACAC CACACACTGG CTCTCGAACC CCGGACGCGC 6120 AGAAGGGACC CGGGCGCGGG TCCGCCGGTA AGAGCCGGGG GGAACATCGG CACCGCCATC 6180

CCACCCCGAG CTGTTGGGTG GGCGGGTGGG GGGGCTGGTG AGGCGGTGGT GGGAGGGGGC 6240

GGCGTATAGC AGGACAACGA CCGGCGGCGA TGTTTTGTGC CGCGGGCGGC CCGACTTCCC 6300

CCGGGGGGAA GTCGGCGGCT CGGGCGGCGT CTGGGTTTTT TGCCCCCCAC AACCCCCGGG 6360

GAGCCACCCA GACGGCACCG CCGCCTTGCC GCCGGCAGAA CTTCTACAAC CCCCACCTCG 6420 CTCAGACCGG AACGCAGCCA AAGGCCCCCG GGCCGGCTCA GCGCCATACG TACTACAGCG 6480

AGTGCGACGA ATTTCGATTT ATCGCCCCGC GTTCGCTGGA CGAGGACGCC CCCGCGGAGC 6540

AGCGCACCGG GGTCCACGAC GGCCGCCTCC GGCGCGCCCC TAAGGTGTAC TGCGGGGGGG 6600

ACGAGCGCGA CGTCCTCCGC GTGGGCCCGG AGGGCTTCTG GCCGCGTCGC TTGCGCCTGT 6660

GGGGCGGTGC GGACCATGCC CCCGAGGGGT TCGACCCCAC CGTCACCGTC TTCCACGTGT 6720 ACGACATCCT GGAGCACGTG GAACACGCGT ACAGCATGCG CGCCGCCCAG CTCCACGAGC 6780

GATTTATGGA CGCCATCACG CCCGCCGGGA CCGTCATCAC GCTTCTGGGT CTGACCCCCG 6840

AAGGCCATCG CGTCGCCGTT CACGTCTACG GCACGCGGCA GTACTTTTAC ATGAACAAGG 6900

CAGAGGTGGA TCGGCACCTG CAGTGCCGTG CCCCGCGCGA TCTCTGCGAG CGCCTGGCGG 6960

CGGCCCTGCG CGAGTCGCCG GGGGCGTCGT TCCGCGGCAT CTCCGCGGAC CACTTCGAGG 7020 CGGAGGTGGT GGAGCGCGCC GACGTGTACT ATTACGAAAC GCGCCCGACC CTGTACTACC 7080

GCGTCTTCGT GCGAAGCGGG CGCGCGCTGG CCTACCTGTG CGACAACTTT TGCCCCGCGA 7140

TCAGGAAGTA CGAGGGGGGC GTCGACGCCA CCACCCGGTT TATCCTGGAC AACCCGGGGT 7200

TTGTCACCTT CGGCTGGTAC CGCCTCAAGC CCGGCCGCGG GAACGCGCCG GCCCAACCGC 7260

GCCCCCCGAC GGCGTTCGGA ACCTCGAGCG ACGTCGAGTT TAACTGCACG GCGGACAACC 7320 TGGCCGTCGA GGGGGCCATG TGTGACCTGC CGGCCTACAA GCTCATGTGC TTCGATATCG 7380

AATGCAAGGC CGGGGGGGAG GACGAGCTGG CCTTTCCGGT CGCGGAACGC CCGGAAGACC 7440

TCGTCATCCA GATCTCCTGT CTGCTCTACG ACCTGTCCAC CACCGCCCTC GAGCACATCC 7500

TCCTGTTTTC GCTCGGATCC TGCGACCTCC CCGAGTCCCA CCTCAGCGAT CTCGCCTCCA 7560

GGGGCCTGCC GGCCCCCGTC GTCCTGGAGT TTGACAGCGA ATTCGAGATG CTGCTGGCCT 7620 TCATGACCTT CGTCAAGCAG TACGGCCCCG AGTTCGTGAC CGGGTACAAC ATCATCAACT 7680

TCGACTGGCC CTTCGTCCTG ACCAAGCTGA CGGAGATCTA CAAGGTCCCG CTCGACGGGT 7740

ACGGGCGCAT GAACGGCCGG GGTGTGTTCC GCGTGTGGGA CATCGGCCAG AGCCACTTTC 7800

AGAAGCGCAG CAAGATCAAG GTGAACGGGA TGGTGAACAT CGACATGTAC GGCATCATCA 7860

CCGACAAGGT CAAACTCTCC AGCTACAAGC TGAACGCCGT CGCCGAGGCC GTCTTGAAGG 7920 ACAAGAAGAA GGATCTGAGC TACCGCGACA TCCCCGCCTA CTACGCCTCC GGGCCCGCGC 7980

AGCGCGGGGT GATCGGCGAG TATTGTGTGC AGGACTCGCT GCTGGTCGGG CAGCTGTTCT 8040

TCAAGTTTCT GCCGCACCTG GAGCTTTCCG CCGTCGCGCG CCTGGCGGGC ATCAACATCA 8100

CCCGCACCAT CTACGACGGC CAGCAGATCC GCGTCTTCAC GTGCCTCCTG CGCCTTGCGG 8160 GCCAGAAGGG CTTCATCCTG CCGGACACCC AGGGGCGGTT TCGGGGCCTC GACAAGGAGG 8220

CGCCCAAGCG CCCGGCCGTG CCTCGGGGGG AAGGGGAGCG GCCGGGGGAC GGGAACGGGG 8280

ACGAGGATAA GGACGACGAC GAGGACGGGG ACGAGGACGG GGACGAGCGC GAGGAGGTCG 8340

CGCGCGAGAC CGGGGGCCGG CACGTTGGGT ACCAGGGGGC CCGGGTCCTC GACCCCACCT 8400 CCGGGTTTCA CGTCGACCCC GTGGTGGTGT TTGACTTTGC CAGCCTGTAC CCCAGCATCA 8460

TCCAGGCCCA CAACCTGTGC TTCAGTACGC TCTCCCTGCG GCCCGAGGCC GTCGCGCACC 8520

TGGAGGCGGA CCGGGACTAC CTGGAGATCG AGGTGGGGGG CCGACGGCTG TTCTTCGTGA 8580

AGGCCCACGT ACGCGAGAGC CTGCTGAGCA TCCTGCTGCG CGACTGGCTG GCCATGCGAA 8640

AGCAGATCCG CTCGCGGATC CCCCAGAGCA CCCCCGAGGA GGCCGTCCTC CTCGACAAGC 8700 AACAGGCCGC CATCAAGGTG GTGTGCAACT CGGTGTACGG GTTCACCGGG GTGCAGCACG 8760

GTCTTCTGCC CTGCCTGCAC GTGGCCGCCA CCGTGACGAC CATCGGCCGC GAGATGCTCC 8820

TCGCGACGCG CGCGTACGTG CACGCGCGCT GGGCGGAGTT CGATCAGCTG CTGGCCGACT 8880

TTCCGGAGGC GGCCGGCATG CGCGCCCCCG GTCCGTACTC CATGCGCATC ATCTACGGGG 8940

ACACGGACTC CATTTTCGTT TTGTGCCGCG GCCTCACGGC CGCGGGCCTG GTGGCCATGG 9000 GCGACAAGAT GGCGAGCCAC ATCTCGCGCG CGCTGTTCCT CCCCCCGATC AAGCTCGAGT 9060

GCGAAAAAAC GTTCACCAAG CTGCTGCTCA TCGCCAAGAA AAAGTACATC GGCGTCATCT 9120

GCGGGGGCAA GATGCTCATC AAGGGCGTGG ATCTGGTGCG CAAAAACAAC TGCGCGTTTA 9180

TCAACCGCAC CTCCAGGGCC CTGGTCGACC TGCTGTTTTA CGACGATACC GTATCCGGAG 9240

CGGCCGCCGC GTTAGCCGAG CGCCCCGCAG AGGAGTGGCT GGCGCGACCC CTGCCCGAGG 9300 GACTGCAGGC GTTCGGGGCC GTCCTCGTAG ACGCCCATCG GCGCATCACC GACCCGGAGA 9360

GGGACATCCA GGACTTTGTC CTCACCGCCG AACTGAGCAG ACACCCGCGC GCGTACACCA 9420

ACAAGCGCCT GGCCCACCTG ACGGTGTATT ACAAGCTCAT GGCCCGCCGC GCGCAGGTCC 9480

CGTCCATCAA GGACCGGATC CCGTACGTGA TCGTGGCCCA GACCCGCGAG GTAGAGGAGA 9540

CGGTCGCGCG GCTGGCCGCC CTCCGCGAGC TAGACGCCGC CGCCCCAGGG GACGAGCCCG 9600 CCCCCCCAGC GGCCCTGCCC TCCCCGGCCA AGCGCCCCCG GGAGACGCCG TCGCATGCCG 9660

ACCCCCCGGG AGGCGCGTCC AAGCCCCGCA AGCTGCTGGT GTCCGAGCTG GCGGAGGATC 9720

CCGGGTACGC CATCGCCCGG GGCGTTCCGC TCAACACGGA CTATTACTTC TCGCACCTGC 9780

TGGGGGCGGC CTGCGTGACG TTCAAGGCCC TGTTTGGAAA TAACGCCAAG ATCACCGAGA 9840

GTCTGTTAAA GAGGTTTATT CCCGAGACGT GGCACCCCCC GGACGACGTG GCCGCGCGGC 9900 TCAGGGCCGC GGGGTTCGGG CCGGCGGGGG CCGGCGCTAC GGCGGAGGAA ACTCGTCGAA 9960

TGTTGCATAG AGCCTTTGAT ACTCTAGCAT GAGCCCCCCG TCGAAGCTGA TGTCCCGCAT 10020

CTTGCAATAA ATGTCTGCGG CCGACACGGT CGGAATTTCC GCGTCCGCTG GTTTCTCTGC 10080

GTTGCGTCTG ACCACGAGCA CAAACGTGCT CTGCCACACG TGGGCGGCGA ACCGGTAGCC 10140

GGGGCACGCG GTCAGCATCC GATCGATGAG CCGGTAGTGC AGGTGGGCCG ACGTGCCGGG 10200 GAAGATGACG TACAGCATGT GGCCCCCGTA CGTGGGGTCC GGGTAAAAAA GAAACCGGGG 10260

GTCGCACGCC CCCCCTCCGC GCAGGATCGT GTGCACGAAA AAGAGCTCGG GCTGGCCGAG 10320

CGTATCGGCC AGGAGGTCCT GGAGGGGGGT GCTGTGGCGG TCGGCCAGCA CGACCAGGGA 10380

GGCCAGAAAG GTGCGGTGCT CAAAGATCGT ATTGATCTGC TGCACGAAGG CCAGGATGAG 10440

GGCCTCGCGG CTGACGGTGG CCAGCCGCCC GTCGCCCGCG CTGCACGCGG GGCAGCAGCC 10500 CCCGATCCCC AGGTAGTAGC CCATGCCCGA GAGGGTCAGG CAGTTGTCGG CCACGGTCTG 10560

GTCCAGGCTG AAGGGGAGCG ACACGGGGGT CGTCTTCACC AGGGGCACGG ATAGCGAGCG 10620

CACGATGGCG ATCTCCTCGG AGGGCGTCTG GGCGAGGGCG GCGAAGAAGC CGCGGTAGCG 10680

ACGGCGCTCG TGCAGGCAGA GCTCCAGCCT GCGCGCGTGC GACGGCAGGC TCTTGCGGGA 10740 GGCCCGGCGC TCCACGCCGG GGTTCCCGGC GGCGGAAAAG CGCGACCGCC GCCGGGTCTT 10800

GTCGCGGCCG GGCCCGGGCC GGGAGCCGGA GCGACGGGGG GCGATGTCAT ACATAGGTAC 10860

AGAGGGTGTG CTCCAGGGAC AGGAGAGAGA TCGAGTGTCG TCTGAGCAGC GCGCCGGCCT 10920

CGCGGACAAA TGTGGCCAGC GCGGTGGGCT TCGGCACAAA TACCTGGTAC GTCTTGAAGG 10980 TGTAGATGAG GGCCCGCAGG GCTATACAGA CCCGCCCCTC GAACTCGTTG CCGCAGGCCA 11040

ACTTGGCCTT GTGAAGCTGC AGCTCGTCGC GATGGTCGGC GCGGGGGTGG CCAAACAGGA 11100

CCCAGGGGTC GACTTCCATC TCCGTGATGG CGCACATGGG ATCGCAGAAC ATGTGCTTGA 11160

AGATGGCCTC GGGGCCCGCG GCCCGAAGCA GGCTCACGAA CCGGCCCCCG TCCCCGGGCT 11220

GCGCCTCGGG GTCCGCCTCG AGCTGGTCCA CGACCGGCAC TATGCAGTCG AAGAGGCTGG 11280 TGTTGTTCTC CGAGTAGCGG ACGACGGACG CCCTCAGGCG TCGCATGGCC AGCCAGTAGG 11340

CCCGCACCAG CAACAGATTG CACAGCAGGC ATTCCCCGCC GGTGCGCCCG CGGCCCCGGC 11400

CGTGCTTCAG CACGGTGGCC ATCAGCGGGC CCAGGTCCAG GTCGGGCTGG GCCTTGGGCT 11460

CGGCGAACTG CGCAAAGCGC GGGGCCGCGT CGCGCATGCG CGCCCCGCGG TGCGCTTCCC 11520

AGGACTCGCT GACCGCGGCG CGGCGGGCGT CCGCGGCGGC GCGCAGCCGG GGCCCCGACT 11580 CCCAGACGGC GGGGGTGCCG GCGAGCAGCA GCAGGATCAG GTCGGCGTAC GCCCACGTCT 11640

CCGGCTCACC CCCCTGCGCC AGCGCCCCGG CGGCGGCCTC GAACTCCCCG TTGCGGGCGG 11700

CGGCGCGCGT GCAGCAGCTG TCTCCGCCCC CGCGCTTGCC CTCGGTGCAG TCGAGCAGGC 11760

GGGCGCAGTC CTTCCAGTTC ATCAGGGCGG TGGTGAGGGA GGGTTGCGTT CCCGAGCCCC 11820

CGCCCGCCCC CGCCCCGTCA TCGCCCCCGG AGGCCAGGGT CCCGATGAGG GCCCGGGTTG 11880 CGGACTGCGC GAGGAAGGAA TAGTTGGAGT ACTGCACCTT GGCGGCGCCC GGGGAGGGCG 11940

TCGGCCTGGG TTGCTTCTGG GCGTGGCGCC CGGGCACCCC GCCGTCGGTC CGGAAGCAGC 12000

AGTGGAGAAA GAAATGCCGG TGGATGTCGT TGATGGTCAG GGCGAAGCGC GCGAAGGAGC 12060

CGACAAGGGT CGCCTTCTTG GTGCGCAGGA AGTGGTGGTC CATGACGTAG ACGAACTCGA 12120

AGGCGGCCAC GAAGATGCTC GCGGCGCAGT GGGGCGCGCC CAGGCACTTG GCGCAGAGGA 12180 ACGCGTAATC GGCCACCCAC TGGGGCGAGA GGCGGTAGGC CTGCTTGTAC AGCTCGATGG 12240

TGCGGCAGAC CAGACAGGGG CGGTCCAGCG CGAAGGTGTC GACGGACGCC GCGGCGAAGG 12300

GCCCCGTGTC CAAGAGTCCC TCTGCCGTGG GGTCTGCGGG CGGGCCGCGG GCGGACCCCG 12360

GCCCCCGCCC CCCCGAAGCC TCGCGCGCGG CCCCGCGCGG CCGCGGGGGG GCGGGCGCGA 12420

CGTCGCTCTC CACGTCCTCG TCGAGCGCGC TCGCGGGCGG CACGCCTACC ACGTGACAGG 12480 CCGCCAGGAG CTCGGCGCAC AGGGCCTCGT TAAGAGCCAG AAGGTCGGGA TCGAAGGCCA 12540

CATACGGACG CTCGAACGCG CCCTCCTTCC AGCTGCTGCC CGGCGACTCT TCGCGCACGG 12600

CGGCGCTCGA CGGCACCCCC GGGGCGGACG TCGCCATGGC CGGTCGAGCG GGGCGCACGC 12660

GTCCGCGAAC GTTACGGGAC GCGATCCCCG ACTGCGCGCT GCGGTCCCAG ACCCTGGAAA 12720

GTCTAGACGC GCGCTACGTC TCGCGAGACG GCGCGGGGGA CGCGGCCGTC TGGTTCGAGG 12780 ACATGACCCC CGCCGAACTA GAGGTTATAT TCCCGACCAC GGACGCCAAG CTGAACTACC 12840

TCTCGCGGAC GCAGCGGCTG GCCTCCCTCC TGACGTACGC CGGGCCTATA AAAGCGCCCG 12900

ACGGCCCCGC CGCCCCACAT ACGCAGGACA CCGCGTGCGT GCACGGCGAG CTGCTCGCCC 12960

GAAAGCGCGA ACGGTTCGCG GCGGTCATTA ACCGGTTCCT GGACCTGCAC CAGATCCTGC 13020

GGGGCTGACG CGCGCTTCGG CGGGGCACCG GCACCGGGAC CGACTTGTTT TACATAACAG 13080 TAGGGGGTGG GGGAACGCGC ACCCTTGCCC GGTCGCGATG GCGGGGATGG GGAAGCCCTA 13140

CGGCGGCCGC CCGGGGGACG CGTTCGAGGG TCTCGTTCAG CGCATCAGGC TCATTGTTCC 13200

CACCACGCTG CGCGGCGGGG GTGGGGAGTC GGGCCCCTAC TCGCCATCCA ACCCGCCCTC 13260

GAGATGTGCC TTCCAGTTCC ACGGCCAGGA TGGGTCCGAC GAGGCCTTCC CGATCGAGTA 13320 CGTCCTGCGG CTCATGAACG ACTGGGCCGA TGTGCCCTGC AACCCCTACC TGCGCGTGCA 13380

GAACACCGGC GTTTCGGTGC TGTTTCAGGG GTTTTTTAAC CGGCCCCACG GCGCCCCGGG 13440

GGGCGCGATC ACGGCGGAGC AGACCAAGGT GATTCTGCAC TCCACCGAGA CGACGGGACT 13500

GTCCCTCGGA GACCTGGACG ACGTCAAGGG GCGCCTCGGC CTGGACGCCC GGCCGATGAT 13560 GGCCAGCATG TGGATCAGCT GCTTTGTGCG CATGCCCCGG GTGCAGCTCG CGTTTCGGTT 13620

CATGGGCCCC GAGGACGCCG TTCGCACGCG GCGGATCCTG TGTCGCGCCG CCGAGCAGGC 13680

CCTCGCCCGT CGCCGCCGGT CCAGGCGGTC CCAGGATGAC TACGGGGCGG TGGCGGTGGC 13740

GGCGGCGCAC CACTCTTCCG GAGCGCCCGG GCCGGGGGTC GCCGCCTCGG GCCCGCCAGC 13800

GCCGCCCGGA CGGGGACCGG CCCGTCCGTG GCATCAGGCC GTGCAGTTGT TCCGGGCCCC 13860 GCGTCCGGGC CCCCCGGCGC TTCTGTTGCT GGTGGCGGGG CTGTTTCTGG GGGCCGCTAT 13920

CTGGTGGGCG GTTGGCGCGC GCCTATGAAA GGGGGCGAGC CACCGTCCCG CCCGCCAGTG 13980

CATCCCAGAC GCCCGCGAGC CGCACATCCC CTCCGCTCCC GCCTCCGGCC CGATTCTTAC 14040

GGCGCGACCC AAGGTCCCGA TGGCCGCCCC GCAGTTTCAC CGCCCCAGCA CCATTACCGC 14100

CGACAACGTC CGGGCGCTCG GCATGCGCGG GCTCGTGTTG GCCACCAACA ACGCTCAGTT 14160 CATCATGGAT AACAGCTACC CGCATCCGCA CGGAACGCAG GGTGCGGTGC GAGAGTTTCT 14220

TCGCGGGCAG GCCGCGGCGC TGACGGACCT CGGGGTGACC CACGCCAACA ACACGTTCGC 14280

CCCGCAGCCT ATGTTCGCGG GCGACGCCGC GGCCGAATGG CTGCGGCCCT CGTTCGGTCT 14340

TAAGCGCACG TATTCCCCCT TTGTCGTTCG CGACCCCAAG ACCCCCAGCA CCCCGTGAGT 14400

CCTCGGCGGG TCCCTCCGCG GCCGTCTCTC GTTGCCCCCC CTTTCCCCCT TCCCGGGTGG 14460 TTCAATAAAA AACACCAACA TACGATATTC GCGTTTGATA CGTTTATTGG GGGGGTGTAG 14520

GGCCCAACGA TCGGCGATTA ACAACACCAA ACAATCGAGC GCGTCTAACC CAGTAACATG 14580

CGCACGTGAT GTAGGCTGGT CAGCACGGCG TTGCTGCGCT GAAACAGCGC CCTGCGGGTC 14640

CGCTGCAGCT GTTGTTGTAT GCGGCGGCAT GCGCGGATCA AAACCGCCAG GGCGCTACGA 14700

CCGGTGCTTC GTACGTAGCG TCGCGACAAG ACGGCATTTG CCTGTACGGG CAAGGGGCCA 14760 AATTGCGAGT GTGGTGACTG GAGGTGGTCG GCGGCCAATG GGCCGGGTGG TTCGTCGGCG 14820

GGGGGCAAGT GCGGTTCCGG TGGGAGGGGG TCGAGCGCCT CGGTATCATC CGAGTCCGAG 14880

AAACGCAGGG AGTCTGCGTC GGAGTGTTCA TCATCGGAGG AGATGT 14927

(2) INFORMATION FOR SEQ ID NO: 131:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 495 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 131:

Met Ala Ala Ala Pro Pro Ala Ala Val Ser Glu Pro Thr Ala Ala Arg

1 5 10 15

Gin Lys Leu Leu Ala Leu Leu Gly Gin Val Gin Thr Tyr Val Phe Gin 20 25 30

Leu Glu Leu Leu Arg Arg Cys Asp Pro Gin Ile Gly Leu Gly Lys Leu 35 40 45

Ala Gin Leu Lys Leu Asn Ala Leu Gin Val Arg Val Leu Arg Arg His

50 55 60

Leu Arg Pro Gly Leu Glu Ala Gin Ala Ala Ala Phe Leu Thr Pro Leu

65 70 75 80

Ser Val Thr Leu Glu Leu Leu Leu Glu Tyr Ala Trp Arg Glu Gly Glu

85 90 95

Arg Leu Leu Gly His Leu Glu Thr Phe Ala Thr Thr Gly Asp Val Ser

100 105 110

Ala Phe Phe Thr Glu Thr Met Gly Leu Ala Arg Pro Cys Pro Tyr His 115 120 125

Gin Gin Ile Arg Leu Glu Thr Tyr Gly Gly Asp Val Arg Met Glu Leu

130 135 140

Cys Phe Leu His Asp Val Glu Asn Phe Leu Lys Gin Leu Asn Tyr Cys

145 150 155 160

His Leu Ile Thr Pro Pro Ser Gly Ala Thr Ala Ala Leu Glu Arg Val 165 170 175

Arg Glu Phe Met Val Ala Ala Val Gly Ser Gly Leu Ile Val Pro Pro

180 185 190

Glu Leu Ser Asp Pro Ser His Pro Cys Ala Val Cys Phe Glu Glu Leu 195 200 205

Cys Val Thr Ala Asn Gin Gly Ala Thr Ile Ala Arg Arg Leu Ala Asp

210 215 220

Arg Ile Cys Asn His Val Thr Gin Gin Ala Gin Val Arg Leu Asp Ala

225 230 235 240

Asn Glu Leu Arg Arg Tyr Leu Pro His Ala Ala Gly Leu Ser Asp Ala 245 250 255

Ala Arg Ala Arg Ala Leu Cys Val Leu Asp Gin Ala Arg Thr Ala Ala

260 265 270

Gly Gly Gly Ala Arg Ala Gly Pro Pro Pro Ala Asp Ser Ser Ser Val 275 280 285

Arg Glu Glu Ala Asp Ala Leu Leu Glu Ala His Asp Val Phe Gin Ala

290 295 300

Thr Thr Pro Gly Ala Ile Ser Glu Leu Arg Phe Trp Leu Ala Ser Gly

305 310 315 320

Asp Arg Ala Arg His Ser Thr Met Asp Ala Phe Ala Asp Asn Leu Asn 325 330 335

Ala Gin Arg Glu Leu Gin Gin Glu Thr Ala Ala Val Ala Val Glu Leu

340 345 350

Ala Leu Phe Gly Arg Arg Ala Glu His Phe Asp Arg Ala Phe Gly Gly 355 360 365 His Leu Ala Ala Leu Asp Met Val Asp Ala Leu Ile Ile Gly Gly Gin

370 375 380

Ala Thr Ser Pro Asp Asp Gin Ile Glu Ala Leu Ile Arg Ala Cys Tyr 385 390 395 400 Asp His His Leu Thr Thr Pro Leu Leu Arg Arg Leu Val Ser Pro Glu

405 410 415

Gin Cys Asp Glu Glu Ala Leu Arg Arg Val Leu Ala Arg Leu Gly Ala

420 425 430

Gly Gly Ala Thr Gly Gly Ala Glu Glu Glu Glu Pro Arg Ala Ala Ala 435 440 445

Glu Glu Gly Gly Arg Arg Arg Gly Ala Gly Thr Pro Ala Ser Glu Asp

450 455 460

Gly Glu Arg Gly Pro Glu Pro Gly Ala Gin Gly Pro Glu Ser Trp Gly 465 470 475 480 Asp Ile Ala Thr Arg Ala Ala Ala Asp Val Xaa Xaa Xaa Xaa Xaa

485 490 495

(2) INFORMATION FOR SEQ ID NO: 132:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1186 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 132:

Met Asp Thr Lys Pro Lys Thr Thr Thr Thr Val Lys Val Pro Pro Gly 1 5 10 15

Pro Met Gly Tyr Val Tyr Gly Arg Ala Cys Pro Ala Glu Gly Leu Glu

20 25 30

Leu Leu Ser Leu Leu Ser Ala Arg Ser Gly Asp Ala Asp Val Ala Val 35 40 45

Ala Pro Leu Ile Val Gly Leu Thr Val Glu Ser Gly Phe Glu Ala Asn

50 55 60

Val Ala Ala Val Val Gly Ser Arg Thr Thr Gly Leu Gly Gly Thr Ala 65 70 75 80 Val Ser Leu Lys Leu Met Pro Ser His Tyr Ser Pro Ser Val Tyr Val

85 90 95

Phe His Gly Gly Arg His Leu Ala Pro Ser Thr Gin Ala Pro Asn Leu 100 105 110 Thr Arg Leu Cys Glu Arg Ala Arg Arg His Phe Gly Phe Ser Asp Tyr

115 120 125

Ala Pro Arg Pro Cys Asp Leu Lys His Glu Thr Thr Gly Asp Ala Leu

130 135 140 Cys Glu Arg Leu Gly Leu Asp Pro Asp Arg Ala Leu Leu Tyr Leu Val

145 150 155 160

Ile Thr Glu Gly Phe Arg Glu Ala Val Cys Ile Ser Asn Thr Phe Leu

165 170 175

His Leu Gly Gly Met Asp Lys Val Thr Ile Gly Asp Ala Glu Val His 180 185 190

Arg Ile Pro Val Tyr Pro Leu Gin Met Phe Met Pro Asp Phe Ser Arg

195 200 205

Val Ile Ala Asp Pro Phe Asn Cys Asn His Arg Ser Ile Gly Glu Asn

210 215 220 Phe Asn Tyr Pro Leu Pro Phe Phe Asn Arg Pro Leu Ala Arg Leu Leu

225 230 235 240

Phe Glu Ala Val Val Gly Pro Ala Ala Val Arg Ala Arg Asn Val Asp

245 250 255

Ala Val Ala Arg Ala Ala Ala His Leu Ala Phe Asp Glu Asn His Glu 260 265 270

Gly Ala Ala Leu Pro Ala Asp Ile Thr Phe Thr Ala Phe Glu Ala Ser

275 280 285

Gin Gly Lys Pro Gin Arg Gly Ala Arg Asp Ala Gly Asn Lys Gly Pro

290 295 300 Ala Gly Gly Phe Glu Gin Arg Leu Ala Ser Val Met Ala Gly Asp Ala

305 310 315 320

Ala Leu Glu Ser Ile Val Ser Met Ala Val Phe Asp Glu Pro Pro Pro

325 330 335

Asp Ile Thr Thr Trp Pro Leu Leu Glu Gly Gin Glu Thr Pro Ala Ala 340 345 350

Arg Ala Gly Ala Val Gly Ala Tyr Leu Ala Arg Ala Ala Gly Leu Val

355 360 365

Gly Ala Met Val Phe Ser Thr Asn Ser Ala Leu His Leu Thr Glu Val

370 375 380 Asp Asp Ala Gly Pro Ala Asp Pro Lys Asp His Ser Lys Pro Ser Phe

385 390 395 400

Tyr Arg Phe Phe Leu Val Pro Gly Thr His Val Ala Ala Asn Pro Gin

405 410 415

Leu Asp Arg Glu Gly His Val Val Pro Gly Tyr Glu Gly Arg Pro Thr 420 425 430

Ala Pro Leu Val Gly Gly Thr Gin Glu Phe Ala Gly Glu His Leu Ala

435 440 445

Met Leu Cys Gly Phe Ser Pro Ala Leu Leu Ala Lys Met Leu Phe Tyr 450 455 460

Leu Glu Arg Cys Asp Gly Gly Val Ile Val Gly Arg Gin Glu Met Asp 465 470 " 475 480

Val Phe Arg Tyr Val Ala Asp Ser Gly Gin Thr Asp Val Pro Cys Asn 485 490 495

Leu Cys Thr Phe Glu Thr Arg His Ala Cys Ala His Thr Thr Leu Met

500 505 510

Arg Leu Arg Ala Arg His Pro Lys Phe Ala Ser Ala Arg Ala Ile Gly 515 520 525 Val Phe Gly Thr Met Asn Ser Ala Tyr Ser Asp Cys Asp Val Leu Gly 530 535 540

Asn Tyr Ala Ala Phe Ser Ala Leu Lys Arg Ala Asp Gly Ser Glu Asn 545 550 555 560

Thr Arg Thr Ile Met Gin Glu Tyr Ala Ala Thr Glu Arg Val Met Ala 565 570 575

Glu Leu Glu Ala Leu Gin Tyr Val Asp Gin Ala Val Pro Thr Ala Leu

580 585 590

Gly Arg Leu Glu Thr Ile Ile Gly Thr Arg Glu Ala Leu His Thr Val 595 600 605 Val Asn Asn Ile Lys Gin Leu Val Asp Arg Glu Val Glu Gin Leu Met 610 615 620

Arg Asn Leu Ile Glu Gly Arg Asn Phe Lys Phe Arg Asp Gly Leu Ala 625 630 635 640

Glu Ala Asn His Ala Met Ser Leu Ser Leu Asp Pro Tyr Thr Cys Gly 645 650 655

Pro Cys Pro Leu Leu Gin Leu Leu Ala Arg Arg Ser Asn Leu Ala Val

660 665 670

Tyr Gin Asp Leu Ala Leu Ser Gin Cys His Gly Val Phe Ala Gly Gin 675 680 685 Ser Val Glu Gly Arg Asn Phe Arg Asn Gin Phe Gin Pro Val Leu Arg 690 695 700

Arg Arg Val Met Asp Leu Phe Asn Asn Gly Phe Leu Ser Ala Lys Thr 705 710 715 720

Leu Thr Val Ser Glu Gly Ala Ala Ile Cys Ala Pro Ser Leu Thr Ala 725 730 735

Gly Gin Thr Ala Pro Ala Glu Ser Ser Phe Glu Gly Asp Val Ala Arg

740 745 750

Val Thr Leu Gly Phe Pro Lys Glu Leu Arg Val Lys Ser Arg Val Leu 755 760 765 Phe Ala Gly Ala Ser Ala Asn Ala Ser Glu Ala Ala Lys Ala Arg Val 770 775 780

Ala Ser Leu Gin Ser Ala Tyr Gin Lys Pro Asp Lys Arg Val Asp Ile 785 790 795 800 Leu Leu Gly Pro Leu Gly Phe Leu Leu Lys Gin Phe His Ala Val Ile

805 810 815

Phe Pro Asn Gly Lys Pro Pro Gly Ser Asn Gin Pro Asn Pro Gin Trp 820 825 830 Phe Trp Thr Ala Leu Gin Arg Asn Gin Leu Pro Ala Arg Leu Leu Ser 835 840 845

Arg Glu Asp Ile Glu Thr Ile Ala Phe Ile Lys Arg Phe Ser Leu Asp

850 855 860

Tyr Gly Ala Ile Asn Phe Ile Asn Leu Ala Pro Asn Asn Val Ser Glu 865 870 875 880

Leu Ala Met Tyr Tyr Met Ala Asn Gin Ile Leu Arg Tyr Cys Asp His

885 890 895

Ser Thr Tyr Phe Ile Asn Thr Leu Thr Ala Val Ile Ala Gly Ser Arg 900 905 910 Arg Pro Pro Gly Val Gin Ala Ala Ala Ala Trp Ala Pro Gin Gly Gly 915 920 925

Ala Gly Leu Glu Ala Gly Ala Arg Ala Leu Met Asp Ser Leu Asp Ala

930 935 940

His Pro Gly Ala Trp Thr Ser Met Phe Ala Ser Cys Asn Leu Leu Arg 945 950 955 960

Pro Val Met Ala Ala Arg Pro Met Val Val Leu Gly Leu Ser Ile Ser

965 970 975

Lys Tyr Tyr Gly Met Ala Gly Asn Asp Arg Val Phe Gin Ala Gly Asn 980 985 990 Trp Ala Ser Leu Leu Gly Gly Lys Asn Ala Cys Pro Leu Leu Ile Phe 995 1000 1005

Asp Arg Thr Arg Lys Phe Val Leu Ala Cys Pro Arg Ala Gly Phe Val

1010 1015 1020

Cys Ala Ala Ser Ser Leu Gly Gly Gly Ala His Glu His Ser Leu Cys 1025 1030 1035 104

Glu Gin Leu Arg Gly Ile Ile Ala Glu Gly Gly Ala Ala Val Ala Ser

1045 1050 1055

Ser Val Phe Val Ala Thr Val Lys Ser Leu Gly Pro Arg Thr Gin Gin 1060 1065 1070 Leu Gin Ile Glu Asp Trp Leu Ala Leu Leu Glu Asp Glu Tyr Leu Ser 1075 1080 1085

Glu Glu Met Met Glu Phe Thr Thr Arg Ala Leu Glu Arg Gly His Gly

1090 1095 1100

Glu Trp Ser Thr Asp Ala Ala Leu Glu Val Ala His Glu Ala Glu Ala 1105 1110 1115 112

Leu Val Ser Gin Leu Gly Ala Ala Gly Glu Val Phe Asn Phe Gly Asp

1125 1130 1135

Phe Gly Asp Glu Asp Asp His Ala Ala Ser Phe Gly Gly Leu Ala Ala 1140 1145 1150

Ala Ala Gly Ala Ala Gly Val Ala Arg Lys Arg Ala Phe His Gly Asp

1155 1160 1165

Asp Pro Phe Gly Glu Gly Pro Pro Glu Lys Lys Asp Leu Thr Leu Asp

1170 1175 1180

Met Leu 1185

(2) INFORMATION FOR SEQ ID NO: 133:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1228 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 133:

Met Phe Cys Ala Ala Gly Gly Pro Thr Ser Pro Gly Gly Lys Ser Ala

1 5 10 15

Ala Arg Ala Ala Ser Gly Phe Phe Ala Pro His Asn Pro Arg Gly Ala 20 25 30 Thr Gin Thr Ala Pro Pro Pro Cys Arg Arg Gin Asn Phe Tyr Asn Pro 35 40 45

His Leu Ala Gin Thr Gly Thr Gin Pro Lys Ala Pro Gly Pro Ala Gin

50 55 60

Arg His Thr Tyr Tyr Ser Glu Cys Asp Glu Phe Arg Phe Ile Ala Pro 65 70 75 80

Arg Ser Leu Asp Glu Asp Ala Pro Ala Glu Gin Arg Thr Gly Val His

85 90 95

Asp Gly Arg Leu Arg Arg Ala Pro Lys Val Tyr Cys Gly Gly Asp Glu 100 105 110 Arg Asp Val Leu Arg Val Gly Pro Glu Gly Phe Trp Pro Arg Arg Leu 115 120 125

Arg Leu Trp Gly Gly Ala Asp His Ala Pro Glu Gly Phe Asp Pro Thr

130 135 140

Val Thr Val Phe His Val Tyr Asp Ile His Val Glu His Ala Tyr Ser 145 150 155 160

Met Arg Ala Ala Gin Leu His Glu Arg Phe Met Asp Ala Ile Thr Pro

165 170 175

Ala Gly Thr Val Ile Thr Leu Leu Gly Leu Thr Pro Glu Gly His Arg 180 185 190

Val Ala Val His Val Tyr Gly Thr Arg Gin Tyr Phe Tyr Met Asn Lys

195 200 205

Ala Glu Val Asp Arg His Leu Gin Cys Arg Ala Pro Arg Asp Leu Cys 210 215 220

Glu Arg Leu Ala Ala Ala Leu Arg Glu Ser Pro Gly Ala Ser Phe Arg

225 230 235 240

Gly Ile Ser Ala Asp His Phe Glu Ala Glu Val Val Glu Arg Ala Asp

245 250 255 Val Tyr Tyr Tyr Glu Trp Thr Leu Tyr Tyr Arg Val Phe Val Arg Ser

260 265 270

Gly Arg Ala Tyr Leu Cys Asp Asn Phe Cys Pro Ala Ile Arg Lys Tyr

275 280 285

Glu Gly Gly Val Asp Ala Thr Thr Arg Phe Ile Leu Asp Asn Pro Gly 290 295 300

Phe Val Thr Phe Gly Trp Tyr Arg Leu Lys Pro Gly Arg Gly Asn Ala

305 310 315 320

Pro Ala Gin Pro Arg Pro Pro Thr Ala Phe Gly Thr Ser Ser Asp Val

325 330 335 Glu Phe Asn Cys Thr Ala Asp Asn Leu Ala Val Glu Gly Ala Met Cys

340 345 350

Asp Leu Pro Ala Tyr Lys Leu Met Cys Phe Asp Ile Glu Cys Lys Ala

355 360 365

Gly Gly Glu Asp Glu Leu Ala Phe Pro Val Ala Glu Arg Pro Glu Asp 370 375 380

Leu Val Ile Gin Ile Ser Cys Leu Leu Tyr Asp Leu Ser Thr Thr Ala

385 390 395 400

Leu Glu His Ile Leu Leu Phe Ser Leu Gly Ser Cys Asp Leu Pro Glu

405 410 415 Ser His Leu Ser Asp Leu Ala Ser Arg Gly Leu Pro Ala Pro Val Val

420 425 430

Leu Glu Phe Asp Ser Glu Phe Glu Met Leu Leu Ala Phe Met Thr Phe

435 440 445

Val Lys Gin Tyr Gly Pro Glu Phe Val Thr Gly Tyr Asn Ile Ile Asn 450 455 460

Phe Asp Trp Pro Phe Val Leu Thr Lys Leu Thr Glu Ile Tyr Lys Val 465 470 475 480

Pro Leu Asp Gly Tyr Gly Arg Met Asn Gly Arg Gly Val Phe Arg Val 485 490 495 Trp Asp Ile Gly Gin Ser His Phe Gin Lys Arg Ser Lys Ile Lys Val 500 505 510

Asn Gly Met Val Asn Ile Asp Met Tyr Gly Ile Ile Thr Asp Lys Val 515 520 525 Lys Leu Ser Ser Tyr Lys Leu Asn Ala Val Ala Glu Ala Val Leu Lys

530 535 540

Asp Lys Lys Lys Asp Leu Ser Tyr Arg Asp Ile Pro Ala Tyr Tyr Ala 545 550 555 560 Ser Gly Pro Ala Gin Arg Gly Val Ile Gly Glu Tyr Cys Val Gin Asp

565 570 575

Ser Leu Leu Val Gly Gin Leu Phe Phe Lys Phe Leu Pro His Leu Glu

580 585 590

Leu Ser Ala Val Ala Arg Leu Ala Gly Ile Asn Ile Thr Arg Thr Ile 595 600 605

Tyr Asp Gly Gin Gin Ile Arg Val Phe Thr Cys Leu Leu Arg Leu Ala

610 615 620

Gly Gin Lys Gly Phe Ile Leu Pro Asp Thr Gin Gly Arg Phe Arg Gly 625 630 635 640 Leu Asp Lys Glu Ala Pro Lys Arg Pro Ala Val Pro Arg Gly Glu Gly

645 650 655

Glu Arg Pro Gly Asp Gly Asn Gly Asp Glu Asp Lys Asp Asp Asp Glu

660 665 670

Asp Gly Asp Glu Asp Gly Asp Glu Arg Glu Glu Val Ala Arg Glu Thr 675 680 685

Gly Gly Arg His Val Gly Tyr Gin Gly Ala Arg Val Leu Asp Pro Thr

690 695 700

Ser Gly Phe His Val Asp Pro Val Val Val Phe Asp Phe Ala Ser Leu 705 710 715 720 Tyr Pro Ser Ile Ile Gin Ala His Asn Leu Cys Phe Ser Thr Leu Ser

725 730 735

Leu Arg Pro Glu Ala Val Ala His Leu Glu Ala Asp Arg Asp Tyr Leu

740 745 750

Glu Ile Glu Val Gly Gly Arg Arg Leu Phe Phe Val Lys Ala His Val 755 760 765

Arg Glu Ser Leu Leu Ser Ile Leu Leu Arg Asp Trp Leu Ala Met Arg

770 775 780

Lys Gin Ile Arg Ser Arg Ile Pro Gin Ser Thr Pro Glu Glu Ala Val 785 790 795 800 Leu Leu Asp Lys Gin Gin Ala Ala Ile Lys Val Val Cys Asn Ser Val

805 810 815

Tyr Gly Phe Thr Gly Val Gin His Gly Leu Leu Pro Cys Leu His Val

820 825 830

Ala Ala Thr Val Thr Thr Ile Gly Arg Glu Met Leu Leu Ala Thr Arg 835 840 845

Ala Tyr Val His Ala Arg Trp Ala Glu Phe Asp Gin Leu Leu Ala Asp

850 855 860

Phe Pro Glu Ala Ala Gly Met Arg Ala Pro Gly Pro Tyr Ser Met Arg 865 870 875 880

Ile Ile Tyr Gly Asp Thr Asp Ser Ile Phe Val Leu Cys Arg Gly Leu

885 - 890 895

Thr Ala Ala Gly Leu Val Ala Met Gly Asp Lys Met Ala Ser His Arg 900 905 910

Ala Leu Phe Leu Pro Pro Ile Lys Leu Glu Cys Glu Lys Thr Phe Thr

915 920 925

Lys Leu Leu Leu Ile Ala Lys Lys Lys Tyr Ile Gly Val Ile Cys Gly

930 935 940 Gly Lys Met Leu Ile Lys Gly Val Asp Leu Val Arg Lys Asn Asn Cys

945 950 955 960

Ala Phe Ile Asn Arg Thr Ser Arg Ala Leu Val Asp Leu Leu Phe Tyr

965 970 975

Asp Asp Thr Val Ser Gly Ala Ala Ala Ala Glu Arg Pro Ala Glu Glu 980 985 990

Trp Leu Ala Arg Pro Leu Pro Glu Gly Leu Gin Ala Phe Gly Ala Val

995 1000 1005

Leu Val Asp Ala His Arg Arg Ile Thr Asp Pro Glu Arg Asp Ile Gin

1010 1015 1020 Asp Phe Val Leu Thr Ala Glu Leu Ser Arg His Pro Arg Ala Tyr Thr

1025 1030 1035 104

Asn Lys Arg Leu Ala His Leu Thr Val Tyr Tyr Lys Leu Met Ala Arg

1045 1050 1055

Arg Ala Gin Val Pro Ser Ile Lys Asp Arg Ile Pro Tyr Val Ile Val 1060 1065 1070

Ala Gin Thr Arg Glu Val Glu Glu Thr Val Ala Arg Leu Ala Ala Leu

1075 1080 1085

Arg Glu Leu Asp Ala Ala Ala Pro Gly Asp Glu Pro Ala Pro Pro Ala

1090 1095 1100 Ala Leu Pro Ser Pro Ala Lys Arg Pro Arg Glu Thr Pro Ser His Ala

1105 1110 1115 112

Asp Pro Pro Gly Gly Ala Ser Lys Pro Arg Lys Leu Leu Val Ser Glu

1125 1130 1135

Leu Ala Glu Asp Pro Gly Tyr Ala Ile Arg Val Pro Leu Asn Thr Asp 1140 1145 1150

Tyr Tyr Phe Ser His Leu Leu Gly Ala Ala Cys Val Thr Phe Lys Ala

1155 1160 1165

Leu Phe Gly Asn Asn Ala Lys Ile Thr Glu Ser Leu Leu Lys Arg Phe 1170 1175 1180 Ile Pro Glu Thr Trp His Pro Pro Asp Asp Val Ala Ala Arg Leu Arg 1185 1190 1195 120

Ala Ala Gly Phe Gly Pro Ala Gly Ala Gly Ala Thr Ala Glu Glu Thr 1205 1210 1215 Arg Arg Met Leu His Arg Ala Phe Asp Thr Leu Ala 1220 1225

(2) INFORMATION FOR SEQ ID NO: 134:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 303 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 134:

Met Tyr Asp Ile Ala Pro Arg Arg Ser Gly Ser Arg Pro Gly Pro Gly

1 5 10 15

Arg Asp Lys Thr Arg Arg Arg Ser Arg Phe Ser Ala Ala Gly Asn Pro 20 25 30 Gly Val Glu Arg Arg Ala Ser Arg Lys Ser Leu Pro Ser His Ala Arg 35 40 45

Arg Leu Glu Leu Cys Leu His Glu Arg Arg Arg Tyr Arg Gly Phe Phe

50 55 60

Ala Ala Gin Thr Pro Ser Glu Glu Ile Ala Ile Val Arg Ser Leu Ser 65 70 75 80

Val Pro Leu Val Lys Thr Thr Pro Val Ser Leu Pro Phe Ser Leu Asp

85 90 95

Gin Thr Val Ala Asp Asn Cys Leu Thr Leu Ser Gly Met Gly Tyr Tyr 100 105 110 Leu Gly Ile Gly Gly Cys Cys Pro Ala Cys Ser Ala Gly Asp Gly Arg 115 120 125

Leu Ala Thr Val Ser Arg Glu Ala Leu Ile Leu Ala Phe Val Gin Gin

130 135 140

Ile Asn Thr Ile Phe Glu His Arg Thr Phe Leu Ala Ser Leu Val Val 145 150 155 160

Leu Ala Asp Arg His Ser Thr Pro Leu Gin Asp Leu Leu Ala Asp Thr

165 170 175

Leu Gly Gin Pro Glu Leu Phe Phe Val His Thr Ile Leu Arg Gly Gly 180 185 190 Gly Ala Cys Asp Pro Arg Phe Leu Phe Tyr Pro Asp Pro Thr Tyr Gly 195 200 205

Gly His Met Leu Tyr Val Ile Phe Pro Gly Thr Ser Ala His Leu His 210 215 220 Tyr Arg Leu Ile Asp Arg Met Leu Thr Ala Cys Pro Gly Tyr Arg Phe

225 230 235 240

Ala Ala His Val Trp Gin Ser Thr Phe Val Leu Val Val Arg Arg Asn

245 250 255 Ala Glu Lys Pro Ala Asp Ala Glu Ile Pro Thr Val Ser Ala Ala Asp

260 265 270

Ile Tyr Cys Lys Met Arg Asp Ile Ser Phe Asp Gly Gly Leu Met Leu

275 280 285

Glu Tyr Gin Arg Leu Tyr Ala Thr Phe Asp Glu Phe Pro Pro Pro 290 295 300

(2) INFORMATION FOR SEQ ID NO: 135:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 597 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 135:

Val Arg Pro Ala Arg Pro Ala Met Ala Thr Ser Ala Pro Gly Val Pro 1 5 10 15

Ser Ser Ala Ala Val Arg Glu Glu Ser Pro Gly Ser Ser Trp Lys Glu

20 25 30

Gly Ala Phe Glu Arg Pro Tyr Val Ala Phe Asp Pro Asp Leu Leu Ala 35 40 45 Leu Asn Glu Ala Leu Cys Ala Glu Leu Leu Ala Ala Cys His Val Val 50 55 60

Gly Val Pro Pro Ala Ser Ala Leu Asp Glu Asp Val Glu Ser Asp Val 65 70 75 80

Ala Pro Ala Pro Pro Arg Pro Arg Gly Ala Ala Arg Glu Ala Ser Gly 85 90 95

Gly Arg Gly Pro Gly Ser Arg Pro Pro Ala Asp Pro Thr Ala Glu Gly

100 105 110

Leu Leu Asp Thr Gly Pro Phe Ala Ala Ala Ser Val Asp Thr Phe Ala 115 120 125 Leu Asp Arg Pro Cys Leu Val Cys Arg Thr Ile Glu Leu Tyr Lys Gin 130 135 140

Ala Tyr Arg Leu Ser Pro Gin Trp Val Ala Asp Tyr Ala Phe Leu Cys 145 150 155 160 Ala Lys Cys Leu Gly Ala Pro His Cys Ala Ala Ser Ile Phe Val Ala

165 170 175

Ala Phe Glu Phe Val Tyr Val Met Asp His His Phe Leu Arg Thr Lys 180 185 190 Lys Ala Thr Leu Val Gly Ser Phe Ala Arg Phe Ala Leu Thr Ile Asn 195 200 205

Asp Ile His Arg His Phe Phe Leu His Cys Cys Phe Arg Thr Asp Gly

210 215 220

Gly Val Pro Gly Arg His Ala Gin Lys Gin Pro Arg Pro Thr Pro Ser 225 230 235 240

Pro Gly Ala Ala Lys Val Gin Tyr Ser Asn Tyr Ser Phe Leu Ala Gin

245 250 255

Ser Ala Thr Arg Ala Leu Ile Gly Thr Leu Ala Ser Gly Gly Asp Asp 260 265 270 Gly Ala Gly Ala Gly Gly Gly Ser Gly Thr Gin Pro Ser Leu Thr Thr 275 280 285

Ala Leu Met Asn Trp Lys Asp Cys Ala Arg Leu Leu Asp Cys Thr Glu

290 295 300

Gly Lys Arg Gly Gly Gly Asp Ser Cys Cys Thr Arg Ala Ala Ala Arg 305 310 315 320

Asn Gly Glu Phe Glu Ala Ala Ala Gly Ala Gin Gly Gly Glu Pro Glu

325 330 335

Thr Trp Ala Tyr Ala Asp Leu Ile Leu Leu Leu Leu Ala Gly Thr Pro 340 345 350 Ala Val Trp Glu Ser Gly Pro Arg Leu Arg Ala Ala Ala Asp Ala Arg 355 360 365

Arg Ala Ala Val Ser Glu Ser Trp Glu Ala His Arg Gly Ala Arg Met

370 375 380

Arg Asp Ala Ala Pro Arg Phe Ala Gin Phe Ala Glu Pro Lys Ala Gin 385 390 395 400

Pro Asp Leu Asp Leu Gly Pro Leu Met Ala Thr Val Leu Lys His Gly

405 410 415

Arg Gly Arg Gly Arg Thr Gly Gly Glu Cys Leu Leu Cys Asn Leu Leu 420 425 430 Leu Val Arg Ala Tyr Trp Leu Ala Met Arg Arg Leu Arg Ala Ser Val 435 440 445

Val Arg Tyr Ser Glu Asn Asn Thr Ser Leu Phe Asp Cys Ile Val Pro

450 455 460

Val Val Asp Gin Leu Glu Ala Asp Pro Glu Ala Gin Pro Gly Asp Gly 465 470 475 480

Gly Arg Phe Val Ser Leu Leu Arg Ala Ala Gly Pro Glu Ala Ile Phe

485 490 495

Lys His Met Phe Cys Asp Pro Met Cys Ala Ile Thr Glu Met Glu Val 500 505 510 ^■

Asp Pro Trp Val Leu Phe Gly His Pro Arg Ala Asp His Arg Asp Glu

515 520 525

Leu Gin Leu His Lys Ala Lys Leu Ala Cys Gly Asn Glu Phe Glu Gly 530 535 540

Arg Val Cys Ile Ala Leu Arg Ala Leu Ile Tyr Thr Phe Lys Thr Tyr 545 550 555 560

Gin Val Phe Val Pro Lys Pro Thr Ala Thr Phe Val Arg Glu Ala Gly 565 570 575 Ala Leu Leu Arg Arg His Ser Ile Ser Leu Leu Ser Leu Glu His Thr 580 585 590

Leu Cys Thr Tyr Val 595

(2) INFORMATION FOR SEQ ID NO: 136:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 128 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 136:

Met Ala Gly Arg Ala Gly Arg Trp Arg Thr Leu Arg Asp Ala Ile Pro

1 5 10 15

Asp Cys Ala Leu Arg Ser Gin Thr Leu Glu Ser Leu Asp Ala Arg Tyr 20 25 30

Val Ser Arg Asp Gly Ala Gly Asp Ala Ala Val Trp Phe Glu Asp Met

35 40 45

Thr Pro Ala Glu Leu Glu Val Ile Phe Pro Thr Thr Asp Ala Lys Leu 50 55 60 Asn Tyr Leu Ser Arg Thr Gin Arg Leu Ala Ser Leu Leu Thr Tyr Ala 65 70 75 80

Gly Pro Ile Lys Ala Pro Asp Gly Pro Ala Ala Pro His Thr Gin Asp

85 90 95

Thr Ala Cys Val His Gly Glu Leu Asp Ala Thr Glu Arg Glu Arg Phe 100 105 110

Ala Ala Val Ile Asn Arg Phe Leu Asp Leu His Gin Ile Leu Arg Gly 115 120 125 ( 2 ) INFORMATION FOR SEQ ID NO : 137 :

( i ) SEQUENCE CHARACTERISTICS : (A) LENGTH : 274 amino acids ( B ) TYPE : amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 137:

Met Ala Gly Met Gly Lys Pro Tyr Gly Gly Arg Pro Gly Asp Ala Phe 1 5 10 15 Glu Gly Leu Val Gin Arg Ile Arg Leu Ile Val Pro Thr Thr Leu Arg 20 25 30

Gly Gly Gly Gly Glu Ser Gly Pro Tyr Ser Pro Ser Asn Pro Pro Ser

35 40 45

Arg Cys Ala Phe Gin Phe His Gly Gin Asp Gly Ser Asp Glu Ala Phe 50 55 60

Pro Ile Glu Tyr Val Leu Arg Leu Met Asn Asp Trp Ala Asp Val Pro 65 70 75 80

Cys Asn Pro Tyr Leu Arg Val Gin Asn Thr Gly Val Ser Val Leu Phe 85 90 95 Gin Gly Phe Phe Asn Arg Pro His Gly Ala Pro Gly Gly Ala Ile Thr 100 105 110

Ala Glu Gin Thr Asn Val Ile Leu His Ser Thr Glu Thr Thr Gly Leu

115 120 125

Ser Leu Gly Asp Leu Asp Asp Val Lys Gly Arg Leu Gly Leu Asp Ala 130 135 140

Arg Pro Met Met Ala Ser Met Trp Ile Ser Cys Phe Val Arg Met Pro

145 150 155 160

Arg Val Gin Leu Ala Phe Arg Phe Met Gly Pro Glu Asp Ala Val Arg

165 170 175 Thr Arg Arg Ile Leu Cys Arg Ala Ala Glu Gin Ala Arg Arg Arg Arg

180 185 190

Ser Arg Arg Ser Gin Asp Asp Tyr Gly Ala Val Ala Val Ala Ala Ala

195 200 205

His His Ser Ser Gly Ala Pro Gly Pro Gly Val Ala Ala Ser Gly Pro 210 215 220

Pro Ala Pro Pro Gly Arg Gly Pro Ala Arg Pro Trp His Gin Ala Val 225 230 235 240

Gin Leu Phe Arg Ala Pro Arg Pro Gly Pro Pro Ala Leu Leu Leu Leu 245 250 255

Val Ala Gly Leu Phe Leu Gly Ala Ala Ile Trp Trp Ala Val Gly Ala

260 - 265 270

Arg Leu

(2) INFORMATION FOR SEQ ID NO: 138:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 112 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 138:

Met Ala Ala Pro Gin Phe His Arg Pro Ser Thr Ile Thr Ala Asp Asn 1 5 10 15

Val Arg Ala Leu Gly Met Arg Gly Leu Val Leu Ala Thr Asn Asn Ala

20 25 30

Gin Phe Ile Met Asp Asn Ser Tyr Pro His Pro His Gly Thr Gin Gly 35 40 45 Ala Val Arg Glu Phe Leu Arg Gly Gin Ala Ala Ala Leu Thr Asp Leu 50 55 60

Gly Val Thr His Ala Asn Asn Thr Phe Ala Pro Gin Pro Met Phe Ala 65 70 75 80

Gly Asp Ala Ala Ala Glu Trp Leu Arg Pro Ser Phe Gly Leu Lys Arg 85 90 95

Thr Tyr Ser Pro Phe Val Val Arg Asp Pro Lys Thr Pro Ser Thr Pro 100 105 110

(2) INFORMATION FOR SEQ ID NO: 139:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 837 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 139: CCCGCTAGTC TGGGGGCGAG GTGCTGCAGG ACCGAGTAGA GGATGGAAAA AACGTCTCGG 60

TCGTAAACCA CGACCGAGCG GGGTCCGATG CAGCCGTCGG GGCCGCTCTC GACGATGGCC 120

ACCAGCGGAC AGTCGGAGTT GTACGTGAGG TACACGCCCG GCGGGTAGCG GTACAGACCT 180 TCGGAGGTCG GGCGGCTGCA GTCGGGGCGG CGCAACTCAA GCTCCCCGCA CCGGTAGACC 240

GACGCAAAGA GTGTGGTGGC GATAATGAGC TCGCGAATAT ATCGCCAGGC GGCGCGCTGG 300

GTGGGCGTGA TTCCGGAAAC ACCGTCAAAA CAGTAGAACT TTTGAAACTC GCTGACGGCC 360

CAATCAGCGC CCGAACCCCC CGCGCCCATG ATGAAGCGGG CGAGTTCCTC CTTGAGGTGC 420

GGCAGGAGCC CCACGTTCTC GACGCTGTAG TACAGCGCGG TGTTGGGGGG CTGGGCGAAG 480 CTGTGGGTGG AGTGGTCGAA CAGGGGCCCG TTGACGAGCT CGAAGAAGCG ATGGGTGATG 540

CTGGGGAGCA GGGCCGGGTC CACCTGGTGG CGCAGCAGCG ACGCTCGCAT GAACCGGTGC 600

GCGTCAAACA CGCCCGGGGC GGCGCGGTTG TCGATGACCG TGCCCGCGCC CGCCGTCAGG 660

GCGCAGAAGC GCGCGCGCGC CGCGAAGCCG TTGGCGACCG CGGCGAAGGT CGCGGGCAGC 720

ACCTCGCCGT GGACGCTGAC CCGCAGCATC TTCTCGAGCT CCCCGCGCTG CTCGCGCACG 780 CAGCGCCCGA GGCTGGCCAG CGACCGCTTG GTCAGGCGGT CCGCGTACAG CCGCCG 837

(2) INFORMATION FOR SEQ ID NO: 140:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 278 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 140:

Arg Arg Leu Tyr Ala Asp Arg Leu Thr Lys Arg Ser Leu Ala Ser Leu 1 5 10 15

Gly Arg Cys Val Arg Glu Gin Arg Gly Glu Leu Glu Lys Met Leu Arg

20 25 30

Val Ser Val His Gly Glu Val Leu Pro Ala Thr Phe Ala Ala Val Ala 35 40 45 Asn Gly Phe Ala Ala Arg Ala Arg Phe Cys Ala Leu Thr Ala Gly Ala 50 55 60

Gly Thr Val Ile Asp Asn Arg Ala Ala Pro Gly Val Phe Asp Ala His 65 70 75 80

Arg Phe Met Arg Ala Ser Leu Leu Arg His Gin Val Asp Pro Ala Leu 85 90 95

Leu Pro Ser Ile Thr Phe Phe Glu Leu Val Asn Gly Pro Leu Phe Asp

100 105 110

His Ser Thr His Ser Phe Ala Gin Pro Pro Asn Thr Ala Leu Tyr Tyr 115 120 125

Ser Val Glu Asn Val Gly Leu Leu Pro His Leu Lys Glu Glu Leu Ala

130 135 - 140

Arg Phe Ile Met Gly Ala Gly Gly Ser Gly Ala Asp Trp Ala Val Ser 145 150 155 160

Glu Phe Gin Lys Phe Tyr Cys Phe Asp Gly Val Ser Gly Ile Thr Pro

165 170 175

Thr Gin Arg Ala Ala Trp Arg Tyr Ile Arg Glu Leu Ile Ile Ala Thr 180 185 190 Thr Leu Phe Ala Ser Val Tyr Arg Cys Gly Glu Leu Glu Leu Arg Arg 195 200 205

Pro Asp Cys Ser Arg Pro Thr Ser Glu Gly Arg Tyr Pro Pro Gly Val

210 215 220

Tyr Leu Thr Tyr Asn Ser Asp Cys Pro Leu Val Ala Ile Val Glu Ser 225 230 235 240

Gly Pro Asp Gly Cys Ile Gly Pro Arg Ser Val Val Val Tyr Asp Arg

245 250 255

Asp Val Phe Ser Ile Lys Val Leu Gin His Leu Ala Pro Arg Leu Ala 260 265 270 Gly Xaa Xaa Xaa Xaa Xaa 275

(2) INFORMATION FOR SEQ ID NO: 141:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2646 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 141:

AAACAATACC AGAAGTCATG TGTATTTTTG AACATCGGTG TCTTTTTATT TATACACAAG 60 CCCAGCTCCC CTCCCCTCCC TTAGAGCTCG TCTTCGTCTC CGGCCTCGTC CTCGTTGTGG 120

AGCGGAGAGT ACCTGGCTTT GTTGCGCTTG CGCAGAACCA TGTTGGTGAC CTTGGAGCTG 180

AGCAGGGCGC TCGTGCCCTT CTTTCTGGCC TTGTGTTCCG TGCGCTCCAT GGCCGACACC 240

AAAGCCATAT ATCGGATCAT TTCTCGGGCC TCGGCCAACT TGGCCTCGTC AAACCCGCCC 300

CCCTCCGCGC CTTCCTCCCC CTCCCCGCCC ACGCCCCCGG GGTCGGAAGT CTTGAGTTCC 360 TTGGTGGTGA GCGGATACAG GGCCTTCATG GGATTGCGTT GCAGTTGCAG GACGTAGCGG 420

AAGGCGAAGA AGGCCGCGAC CAGGCCGGCC AGGACCAGCA GCCCCACGGC AAGCGCCCCG 480

AAGGGGTTGG ACATAAAGGA GGACACGCCC GAGACGGCCG ACACCACGCC CCCCACTACT 540

CCCATGACTA CCTTGCCGAC CGCGCGCCCC AAGTCCCCCA TCCCCTCGAA GAACGCGCAC 600 AGCCCCGCGA ACATGGCGGC GTTGGCGTCG GCGCGGATGA CCGTGTCGAT GTCGGCAAAG 660

CGCAGGTCGT GCAGCTGGTT GCGGCGCTGG ACCTCCGTGT AGTCCAGCAG GCCGCTGTCC 720

TTGATCTCGT GGCGCGTGTA GACCTCCAGG GGCACAAACT CGTGGTCCTC CAGCATGGTG 780

ATGTTCAGGT CGATGAAGGT GCTGACGGTG GTGACGTCGG CGCGACTCAG CTGGTGAGAG 840 TACGCGTACT CCTCGAAGTA CACGTAGCCC CCGCCGAAGA TGAAGTAGCG CCGGTGGCCC 900

ACGGTGCACG GCTCGAGCGC GTCGCGGGTG AGGCGCAGCT CGTTGTTCTC GCCCAGCTGC 960

CCCTCGATCA GCGGGCCCTG GTCTTCGTAC CGAAAGCTGA CCAGGGGGCG GCTGTAGCAC 1020

GTCCCCGGCC GCGAGCTGAC GCGCATCGAG TTCTGCACGA TCACGTTGTC CGGGGCGACG 1080

GGCACGCACG TGGAGACGGC CATGACGTCT CCGAGCATGC GCGCGCTCAC CCGCCGGCCG 1140 ACGGTGGCGG AGGCGATGGC GTTGGGGTTG AGCTTGCGGG CCTCGTTCCA GAGAGTCAGC 1200

TCGTGGTTCT GCAGCTCGCA CCACGCGACG GCGATGCGCC CCAGCATGTC GTTCACGTGG 1260

CGCTGTATGT GGTTATACGT AAACTGCAGC CGGGCGAACT CGATCGAGGA GGTGGTCTTG 1320

ATGCGCTCCA CGGACGCGTT GGCGCTGGGC GCCTCCCGCA GTGGCGCGGG CGTGGCATTC 1380

CGGGGCTTGC GGTCCTGCTC CCGCATGTAC TCCCGCACGT ACAGCTCGGC GAGCGTGTTG 1440 CTGAGGAGGG GCTGGTACGC GATGAGGAAG CCCCCCGTGG CCAGGTAGTA CTGCGGCTGG 1500

CCCACCTTGA TGTGCGTGGC GTTGTACTTG CGCGCAAACA TGCGGTCGAT GGCCTCGCGG 1560

GCATCCCGGC CAATGCAGTC GCCCAGGTCG ACGCGCGAGA GCGAGTACTG GGTCAGGTTG 1620

GTGGTGAAGG TGGTCGAGAT GGCGTCGGAG GAGAAGCGGA AGGAGCCGCC GTACTCGGCG 1680

CGGAGCATCT CGTCCACCTC CTGCCACTTG GTCATGGTGC AGACCGCCGG TCGCTTCGGC 1740 ACCCAGTCCC AGGCCACGGT AAACTTGGGG GTCGTCAGCA AGTTGCGGGT CGTCGGCGAC 1800

GTGGCCCGGG CCTTCGTGGT GAGGTCGCGC GCGTAGAAGC CGTCGACCTG CTTGAAGCGG 1860

TCGGCGGCGT AGCTGGTGTG CTCGGTGTGC GACCCCTCCC GG AGCCGTA AAACGGGGAC 1920

ATGTACACAA AGTCGCCCGT CGCCAACACA AACTCATCGT ACGGGTACAC CGACCGCGCG 1980

TCCACCTCCT CGACGATGCA GTTGACCGTC GTGCCGTACC GATGGAACGC CTCCACCCGC 2040 GAGGGGTTGT ACTTGAGGTC GGTGGTGTGC CACCCCCGGC TCGTGCGCGT GGCGACCTTC 2100

GCCGGCTTGA GCTCCATGTC GGTCTCGTGG TCGTCCCGGT GAAACGCGGT GGTCTCCATG 2160

TTGTTCCGCA CGTACTTGGC CGTGGAGCGG CAGACCCCCT TGGCGTTAAT CTTGTCGATC 2220

ACCTCCTCGA AGGGAACGGG GGCGCGGTCC TCGAATATCC CCATAAACTG GGAGTAGCGG 2280

TGGCCGAACC ACACCTGCGA CACGGTCACG TCTTTGTAGT ACATGGTGGC CTTGAATTTG 2340 TACGGGGCGA TGTTCTCCTT GAAGACCACC GCGATGCCCT CCGTGTAGTT CTGCCCCTCC 2400

GGGCGCGTCG GGCAGCGGCG CGGCTGCTCA AACTGCACCA CCGTGGCGCC CGTCGGGGGC 2460

GGGCACACGT AAAACTGGGC ATCGGCGTTC TCGACCTTGA TTTCCCGCAG GTGCGCGCGC 2520

AGCGTGGCGT GGCCGGCGGC GACGGTCGCG TTGGCGTCGG GGGGCGGGGT CGCCTCGGGC 2580

CGCTTGGGCG GCTTTTTGGT TTTCCGCTTC CGGGCCTTGG TGGTCGCGGG GCTCGGGACG 2640 GGGGG 2646

(2) INFORMATION FOR SEQ ID NO: 142:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 846 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ( ii ) MOLECULE TYPE : peptide

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 142 :

Pro Pro Val Pro Ser Pro Ala Thr Thr Lys Ala Arg Lys Arg Lys Thr

1 5 10 15

Lys Lys Pro Pro Lys Arg Pro Glu Ala Thr Pro Pro Pro Asp Ala Asn 20 25 30 Ala Thr Val Ala Ala Gly His Ala Thr Leu Arg Ala His Leu Arg Glu 35 40 45

Ile Lys Val Glu Asn Ala Asp Ala Gin Phe Tyr Val Cys Pro Pro Pro

50 55 60

Thr Gly Ala Thr Val Val Gin Phe Glu Gin Pro Arg Arg Cys Pro Trp 65 70 75 80

Glu Gly Gin Asn Tyr Thr Glu Gly Ile Ala Val Val Phe Lys Glu Asn

85 90 95

Ile Ala Pro Tyr Lys Phe Lys Ala Thr Met Tyr Tyr Lys Asp Val Thr 100 105 110 Val Ser Gin Val Trp Phe Gly His Arg Tyr Ser Gin Phe Met Gly Ile 115 120 125

Phe Glu Asp Arg Ala Pro Val Pro Phe Glu Glu Val Ile Asp Lys Ile

130 135 140

Asn Ala Lys Gly Val Cys Arg Ser Thr Ala Lys Tyr Val Arg Asn Asn 145 150 155 160

Met Thr Ala Phe His Arg Asp Asp His Glu Thr Asp Met Glu Leu Lys

165 170 175

Pro Ala Lys Val Ala Thr Arg Thr Ser Arg Gly Trp His Thr Thr Asp 180 185 190 Leu Lys Tyr Asn Pro Ser Arg Val Glu Ala Phe His Arg Tyr Gly Thr 195 200 205

Thr Val Asn Cys Ile Val Glu Glu Val Asp Ala Arg Ser Val Tyr Pro

210 215 220

Tyr Asp Glu Phe Val Leu Ala Thr Gly Asp Phe Val Tyr Met Ser Pro 225 230 235 240

Phe Tyr Gly Tyr Arg Glu Gly Ser His Thr Glu His Thr Ser Tyr Ala

245 250 255

Ala Asp Arg Phe Lys Gin Val Asp Gly Phe Tyr Ala Arg Asp Leu Thr 260 265 270 Thr Lys Ala Arg Ala Thr Ser Pro Thr Thr Arg Asn Leu Leu Thr Thr 275 280 285

Pro Lys Phe Thr Val Ala Trp Asp Trp Val Pro Lys Arg Pro Ala Val 290 295 300 Cys Thr Met Thr Lys Trp Gin Glu Val Asp Glu Met Leu Arg Ala Glu

305 310 315 320

Tyr Gly Gly Ser Phe Arg Phe Ser Ser Asp Ala Ile Ser Thr Thr Phe

325 330 335 Thr Thr Asn Leu Thr Gin Tyr Ser Leu Ser Arg Val Asp Leu Gly Asp

340 345 350

Cys Ile Gly Arg Asp Ala Arg Glu Ala Ile Asp Arg Met Phe Ala Arg

355 360 365

Lys Tyr Asn Ala Thr His Ile Lys Val Gly Gin Pro Gin Tyr Tyr Leu 370 375 380

Ala Thr Gly Gly Phe Leu Ile Ala Tyr Gin Pro Leu Leu Ser Asn Thr

385 390 395 400

Leu Ala Glu Leu Tyr Val Arg Glu Tyr Met Arg Glu Gin Asp Arg Lys

405 410 415 Pro Arg Asn Ala Thr Pro Ala Pro Leu Arg Glu Ala Pro Ser Ala Asn

420 425 430

Ala Ser Val Glu Arg Ile Lys Thr Thr Ser Ser Ile Glu Phe Ala Arg

435 440 445

Leu Gin Phe Thr Tyr Asn His Ile Gin Arg His Val Asn Asp Met Leu 450 455 460

Gly Arg Ile Ala Val Ala Trp Cys Glu Leu Gin Asn His Glu Leu Thr

465 470 475 480

Leu Trp Asn Glu Ala Arg Lys Leu Asn Pro Asn Ala Ile Ala Ser Ala

485 490 495 Thr Val Gly Arg Arg Val Ser Ala Arg Met Leu Gly Asp Val Met Ala

500 505 510

Val Ser Thr Cys Val Pro Val Ala Pro Asp Asn Val Ile Val Gin Asn

515 520 525

Ser Met Arg Val Ser Ser Arg Pro Gly Thr Cys Arg Pro Leu Val Ser 530 535 540

Phe Arg Tyr Glu Asp Gin Gly Pro Leu Ile Glu Gly Gin Leu Gly Glu

545 550 555 560

Asn Asn Glu Leu Arg Leu Thr Arg Asp Ala Leu Glu Pro Cys Thr Val

565 570 575 Gly His Arg Arg Tyr Phe Ile Phe Gly Gly Gly Tyr Val Tyr Phe Glu

580 585 590

Glu Tyr Ala Tyr Ser His Gin Leu Ser Arg Ala Asp Val Thr Thr Val

595 600 605

Ser Thr Phe Ile Asp Leu Asn Ile Thr Met Leu Glu Asp His Glu Phe 610 615 620

Val Pro Leu Glu Val Tyr Thr Arg His Glu Ile Lys Asp Ser Gly Leu 625 630 635 640

Leu Asp Tyr Thr Glu Val Gin Arg Arg Asn Gin Leu His Asp Leu Arg 645 650 655

Phe Ala Asp Ile Asp Thr Val Ile Arg Ala Asp Ala Asn Ala Ala Met

660 - 665 670

Phe Ala Gly Leu Cys Ala Phe Phe Glu Gly Met Gly Asp Leu Gly Arg 675 680 685

Ala Val Gly Lys Val Val Met Gly Val Val Gly Gly Val Val Ser Ala

690 695 700

Val Ser Gly Val Ser Ser Phe Met Ser Asn Pro Phe Gly Ala Val Gly 705 710 715 720 Leu Leu Val Leu Ala Gly Leu Val Ala Ala Phe Phe Ala Phe Arg Tyr

725 730 735

Val Leu Gin Leu Gin Arg Asn Pro Met Lys Ala Leu Tyr Pro Leu Thr

740 745 750

Thr Lys Glu Leu Lys Thr Ser Asp Pro Gly Gly Val Gly Gly Glu Gly 755 760 765

Glu Glu Gly Ala Glu Gly Gly Gly Phe Asp Glu Ala Lys Leu Ala Glu

770 775 780

Ala Arg Glu Met Ile Arg Tyr Met Ala Leu Val Ser Ala Met Glu Arg 785 790 795 800 Thr Glu His Lys Ala Arg Lys Lys Gly Thr Ser Ala Leu Leu Ser Ser

805 810 815

Lys Val Thr Asn Met Val Leu Arg Lys Arg Asn Lys Ala Arg Tyr Ser

820 825 830

Pro Leu His Asn Glu Asp Glu Ala Gly Asp Glu Asp Glu Leu 835 840 845

(2) INFORMATION FOR SEQ ID NO: 143:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20388 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 143:

GGATCTCCTC GTTCTCTTGC GTGATGGACA CGTCCTCCGC GGTGGCCGTG TCGCCTCCCG 60

GGGCCGTGAG CTGCTCCTCC GGGGAGATGG GGGGGTCTGG GGTGCCGACA ACGGCCGGCC 120 CGGCCCCGCC CGAGACCGAG GACGCCTGGG GAGTGGGGGT GCCGCTTTCC CCCATCCCCA 180

GGGACAGGTG GGCCGCCGCC TCCGTCGCGG CGGCGGGAGC CGCGGCCCCC AGCCGCGCGA 240

CGTAGCGACA AAAGTGGCGA CAGAGGCGCA TGAGGCGCGC GCCGTCGGCC GCGTATCGCG 300

TGTTTGGCGG GACGAGCTCG TCGTAACTGA ACAGGAGCAC GCGGGCGCAG GTCGCCCACG 360 GGCCCCACGC CAGGCGCAGC GCCGCGACCG TGTACGGGTC GTACACGCCT TGGGCGTCGC 420

ACGCGACCGG CAGGGAGACG AACAGCCCGC CCGCGCTGGG GACGCGCGGC AGGAGGTCCG 480

GGTGCGCCGG GATGACGGGG GCTAGGATCG CCCCCACCGC ATCCGCCGGC ACGTAGGCGG 540

CAAACGCCGA ACGCCACGGG GTGCAGTCGC CGGTCGCGTG GGCCCGGGTC TGGGTTTCGA 600 CCCGGAAGTT CGCGGCCGCC CCGCCGTCGG GGCGGCCGCG CACGAGGGCG GACAGCGGGA 660

CCCCCGCCGC CGCCAGGCAC TCGCTGGAGA TGATGACGTG AATCAGCGAG GCGGGGCTGC 720

TCGGGTCCCG GGTGAGATCG TATTGGACCT CGTTGGCAAA GTGCGCGTTC ATGGCCCGGC 780

CGGCGGTGCG AGCCCTTCCC GGTGCCGGAA GGGGCGTGGG TGGGGGGTGC GTGTGCGCGT 840

CCTCGGGGCC CGCGGGCGCA CGTGCGCTTA TACGCTGTGT GTTTCGTCTG TCCCCAGGGA 900 ATCCGGGGCC AGGACTTTAA CCTGCTTTTC GTCGACGAGG CCAACTTTAT TCGCCCGGAT 960

GCGGTCCAGA CGATTATGGG CTTTCTCAAT CAGGCCAACT GCAAGATCAT CTTCGTCTCG 1020

TCGACCAACA CCGGGAAGGC CAGCACGAGC TTTTTGTACA ACCTCCGCGG GGCCGCCGAC 1080

GAGCTGCTCA ACGTGGTCAC CTATATATGC GACGACCACA TGCCGCGGGT GGTGACGCAC 1140

ACCAACGCCA CGGCCTGTTC CTGCTATATC CTGAACAAAC CCGTGTTTAT CACGATGGAC 1200 GGCGCCGTTC GCCGGACGGC CGATCTGTTT CTGCCCGACT CCTTCATGCA GGAGATCATC 1260

GGGGGGCAGG CCCGCGAGAC CGGCGACGAC CGGCCCGTCC TAACAAAGTC GGCGGGGGAG 1320

CGGTTTCTGC TGTACCGCCC CTCCACCACC ACCAACAGCG GCCTGATGGC CCCCGAGCTG 1380

TACGTGTACG TGGACCCGGC GTTCACGGCC AACACGCGCG CCTCCGGCAC CGGCATCGCG 1440

GTCGTCGGGA GGTACCGCGA CGATTTCATT ATCTTCGCCC TGGAGCACTT TTTCCTCCGC 1500 GCGCTCACGG GATCGGCCCC CGCGGACATC GCCCGCTGCG TCGTGCACAG CCTCGCCCAG 1560

GTGCTGGCGC TGCACCCCGG GGCGTTTCGC AGCGTTCGCG TGGCGGTCGA GGGCAACAGC 1620

AGCCAGGACT CGGCCGTGGC CATCGCCACA CACGTGCATA CCGAGATGCA CCGCATCCTG 1680

GCCTCGGCGG GGGCCAACGG CCCGGGGCCC GAGCTCCTCT TCTATCACTG CGAGCCGCCC 1740

GGCGGCGCGG TATTGTACCC CTTCTTTCTG CTCAACAAAC AGAAGACGCC CGCCTTCGAA 1800 TACTTTATCA AAAAGTTCAA CTCCGGGGGC GTCATGGCGT CCCAGGAGCT CGTCTCCGTG 1860

ACGGTGCGCC TGCAGACCGA CCCGGTCGAG TATCTGTCCG AGCAGCTCAA CAACCTCATC 1920

GAAACCGTCT CTCCCAACAC CGACGTCCGC ATGTACTCCG GAAAACGCAA CGGTGCCGCG 1980

GACGACCTCA TGGTCGCGGT CATCATGGCC ATTTACCTGG CGGCCCCGAC CGGGATCCCC 2040

CCGGCCTTTT TTCCGATCAC GCGCACGTCT TGAGTCTTTC TTGCCGTTTC TTTTGTTTCT 2100 CTTTCTTTCC CCCCTCTCTC CGCAATAAAC GCCTTCCCGG AACTGTGTTT TCCCCCCCTA 2160

CAACAGTGTT GTCCGTTGGT TGGGTGGTTG GGGTGCGGGG GTGGGCGGGG GAAGCAAGAA 2220

AACGGTCGGC GAACACAACA TCGGGAAAAC GGATTCCCGA ACGTGCGTCT TCCCAGATTC 2280

GACACACACC CCCCTTCTCC TTAAATAAAC ACAAACCACA CGCTCGTTGG TTGGTTAATG 2340

CCGGCGCTTT ATTTACGTCT TGTTTTTTTG CGTTTCCTCC GCGGGTCCCT TCCCAACACG 2400 CCTGCCCCCG CCTCAGGGGT AGCGGATAAC CGGGGCCATG TCGCCGGATT GCACAACGGC 2460

GGCGCCGTCG AACGTACACA CCCGAACCGC CGGGGCCAGG GCCAGGATGT CCCCGAGTTG 2520

GCCCGCGTGC GCCAGCCAGG CGACCAGCGC CTCGTAAAGC GGCAGCCTGC GCTCGCCGTC 2580

CTGCATCAGC ATGGGGGCTT CGGGGTGGAT GAGCTGGGCG GCTTCTCGCG TGACGCTCTG 2640

CATCTGCAGG AGCGCGTTCA CGTATCCGTC CTGGGCGCTC AGCGCGAGCA GCCGGGGGAT 2700 GAGCGTGAGG ATGAGGGTGG TTCCTTCGGT TATGGAGTAG ACCATGTTGA GGACGAGCGA 2760

CCGCAGCTCG GTGTTTACGG AGGCGAGTTG CTGGACGTCG GCCACGAGCG AGAGACGGGC 2820

CCCGTTGTAA TACAGCACGT TGAGGTCGGG GAGCTCCCCG GGCGTCCGGG GGTCGGGGTT 2880

GAGGTCCCGG ATGCCCCGGG CGACCAGCCG CGCGACTATC TCGCGGGCCA GGGGCGTTGG 2940 GAGCGGGACC GGAAACCGCA GCGTGAGGTC CAGCGACTCC AGGCGCACGT CCGTCGCCTG 3000

GCCCTCGAAG ACGGGCGGGA CGAGGCTGAC GGGATCCCCG TTGCAGAGGT CGACGGGGGA 3060

GGTGTTGCGG AGATTGACGG TGCCGGCGTG CGTGAGCCCC AGGTCCACGG GGCAGGCGAC 3120

GATTCGCGTG GGCAGCACCC GCGTGATTAC CGCGGGGAAG CGCCTGCGGT ACGCCAGCAA 3180 CAACCCCAAC GTGTCGGGAC TAACTCCTCC GGAGACGAAC GATTCGTGCG CCACGTCCGC 3240

GAGCGCCAGC TGGCGGCGGA TGGTCGGCAG AAAGACCACT CGACCCTCGC ACCGCTGCAG 3300

CGCCGCGGCA TCGGGGCGCG AGATACCCGA GGGGATCGCG ATGTCTGCTT CGAAACAATC 3360

CGTGATCATG GCGCCGGGCC GCGAGACACC GGAACGCGGG GGTGCGGGAG GGCCGGAAAG 3420

CGCAACGCAA CCGGGACGAT GATGAAACAG AGATGGGGGG CACCGACCGT GTGGGAGAGG 3480 GGGCGGGGCA GGGCTCAGCA GCACGCACGG GGAGGTCTGT CGTGCGCAGG AGCCCCAGGT 3540

GAGAATCAGT CCCCCGGAGC TCGGGTCTGG GTTTTATTGG GACCTGCCCT CGGAATCGCG 3600

GCTCCCAGTC CAAGCCCCCC CGGGGGGGCG GGGACAGGGG GTGTGTGTGG GTAAAAGCAA 3660

CGTCGGAAAA TCAAACCCAA TGCCCCAAAC AGGAAAAAAA AAAAAGACGG GCGGGTGGAG 3720

GGAAAGCTGG GGAAGAAGAA GCCAATTTTA CAGAGACAGG CCCTTTAGCG GGGAGGCGTC 3780 GTAGATGAGA TACTGCGTAA AGTGGGTCTC TCGCGCGTGG GCCTCCCCAT CGCGGGCGCT 3840

GCGTAGCAGG GCGGGGTCGC TGGCGCAGGT GATCGGGTAG GCTTCCTGAA ACAGGCCGCA 3900

CGGGTCTTCC ACGAGCTCGC GGCACCCCGG CGGGCGCTTA AACTGCACGT CGCTGGCAGC 3960

GGTGGCCGTG GATACCGCCG ATCCCGTTTC CACGATAAGA CGCTCCAGGC AGCGATGTTT 4020

GGCCGTGATG TCGGCCGCGG TGAAGAACTT GAAGCAGGGG CTGAGGACGG GCGAGGCCCC 4080 GTTGAGGTGA TAGGCCCCGT TGTACAGCAG GTCCCCGTAC GAGAACCGCT GCGACGCCCA 4140

CGGGTTGGCC GTGGCCGCGA AGGGCCGCGC CGGGTCGCTC TGGCCGTGGT CGTACATGAG 4200

GGCTATGACG TCCCCCTCCT TGTCCCCCGC GTACACGCCG CCGGCCGCGC GTCCCCGCGG 4260

GTTGCAGGGC CGGCGAAAGT AGTTGATGTC CGTGGCCACG GGGGTGGCGA TGAACTCACA 4320

CACGGCATCC TGCCCGTGGT CCATGCCGGC GCGCCGCGGC ACCTGGGCGC AGCCAAAGAC 4380 CGGGAGGGGC TGGGCCGGCC CCAGCCGGTT TCCCGCCACG ACCGCGTTGC GCAGGTACAC 4440

GGCGGCCGCG TTGTCTAGCA GCGGGGGGGC CCCGCGGCCG AGGTAAAAGT TTTGGGGGAG 4500

GTTGCCCATG TCCGTAACGG GGTTGCGGAC GGTGGCCGTG GCCGCGACGG CGGTGTAGCC 4560

CACACCCAGG TCCACGTTTC CGCGCGGCTG GGTGAGCGTG AAGCTGACCC CCCCGCCCGT 4620

TTCGTGGCGG GCCACCTGGA GCTGGCCCAG AAAGTACGCC TCCGACGCGC GCTCGGAAAA 4680 CAGCACGTTC TCGGTCACGA AGCGGTCCTG CCGCACGACG GTGAACCCGA ACCCGGGGTG 4740

GAGGCCCGTC TTGAGCTGGT GATACAGGGC CACGGGGCTC ATCTTGAAGT ACCCCGCCAT 4800

GAGCGCGTAG GTCAGCGCGT TCTCCCCCGC CGCGCTCTCG CGGGCGTGCT GCACCACGGG 4860

CTGGCGGATG GAGGAGAAGT AGTTGGCCCC CAGGGCCGGG GGGACCAGGG GGACGTGGCG 4920

CGCCAGGTCG CGCAGGGCCG GGGGGAAGTT GGGCGCGTTG GCCACGTGGT CGGCGCCCGC 4980 AAACAGCGCG TGGACGGGCA GGACGTAGAA GTATTCGCCA TTTTGGATGG TGTGGTCCAG 5040

GTGCTGGGGG GCCATGAGCA GCACGCCGGC GTGCAGCGCC CCGTCGAAGA TGCGCATGTT 5100

GGCCGTCGAC GCGGTGTTGG CGCCCGCGTC GGGCGCCGCG GAGCACAGCA GCGCCGTCGT 5160

GCGCTCGGCC ATGTTGTGCG CCAGCACCTG CAGCGTGAGC ATGGCGGGCC CGTCGACGAC 5220

GACGCGCCCG TTGTGGAACA TGGCGTTGAC CGTGTTGGCC ACCAGATTGG CGGGATGCAG 5280 CGGGTGGGCG GGGTCGGTCA CGGGATCGCT CGGGCACTCC TCGCCGGGGG CGATCTCCGG 5340

GACCACCATG TTCTGCAGCG TGGCGTACAC GCGGTCGAAG CGGACCCCCG CGGTGCAGCA 5400

GCGCCCCCGC GAGAAGGCCG GCACCAGCAC GTAATAGTAG ATTTTGTGGT GGACGGTCCA 5460

GTCGGCCGGC CGGTGCGGCC GGTCGTCGGC GGCGTCGGCC GCGCGGGCCT GGGTGTTGTG 5520 CAGCAGCCGG CCGTCGTTGC GGTTAAAGTC GGCCGTCGCC ACGTTGCACG CCGCCGCGTA 5580

GACGGGCTCG TGTCCCCCCG CGTCAATCCG GCAGTCTCGG TGGCGGTCCA GGGCCGCGTG 5640

TCGCATAAGG CCGTCGCAGT CCCACACGAG GGGCGGCAGC AGCGCCGGGT CGCGCATCAG 5700

GTGATTCAGC TCGGCCTGAG CCTGCCCGCC CAGCTCCGGG CCCGGCAGGG TAAAGTCGTC 5760 CACCAGCTGG GCCAGGGCCT CGACGTGGGC CACCAGGTCC CGATACACGG CCATGCACTC 5820

CTCGGGGAGG TCGCCCCCGA GGTAGGTCAC GATGTACGAG ACCAGCGAGT AGTCGTTCAC 5880

GAACGCCGCG CATCGCGTGT TGTTCCAGTA GCTGGTGATG CACTGAGTCA CGAGCCGCGC 5940

CAGGGCGCAG AACACGTGCT CGCTGCCGTG AATCGCGGCT TGCAGCAGGT AAAACACCGC 6000

CGGGTAGCTG CGGTCCTCGA ACGCCCCGCG GACGGCGGCT ATGGTAGCCG GCGCCATGGC 6060 GTGGCGGCCA ACGCCGAGCT CCAGGCCCCG GGCGTCACGA AACGCCACCG GACACAGCGC 6120

CAGGGGCAGG TTGCCGTTGA CCACGCGCCA GGTGGCCTGG ATCGCCCCCG GACCGGCCGG 6180

GGGGACTTCG CCGCCGGGAA GCTCGACGTC GGCCACGCCC GCGAAGAAGT CGAACGCGGG 6240

GTGCAGCTCC AGAGCCAGGT TGGCGTTGTC GGGCTGCATG AACTGCTCCG CGGTCATCTG 6300

GCACTCGGCG ACCCACCGGA CCCGGCCGTG GGCGAGGCGC TGCCGCCAGG CGTTCAGAAA 6360 ACGCTGCTGC ATGTCCGCGC CGGGGCCGGC CGGGGCCGCG ACGTACGCCC CGTACGGATT 6420

CGCGGCCTCG ACGGGGTCGT GGTTCACGCC CCCGACGGCC GCGTCGATGT TCATGAGCGA 6480

AGGATGACAC ACGGTCCCGA CCGCGTTCTC CATGGACAGC CGCAGAACCT GGTGGTCCTT 6540

TCCCCAAAAA AACAGCTGCC GGGGAGGGAA CGCGCGGGGC TCCGGGTGGC CGGGGGCGGG 6600

CACCAGGTCC CCGGCGTGCG CGGCGAAGCG CTCCATGGCC GGGTTGAACA GCCCCAGGGG 6660 CAGGACGAAC GTCAGGTCCA TGGCGCCCAC CAGGGGGTAG GGCACGTTGG TGGCGGCGTA 6720

GATGCGCTTC TCCAGGGCCT CCAGGAAGAC CAGCCTGTCG CCTATGGCCA CCAGATCCGC 6780

GCGCACGCGC GTTGTCTGGG GGGCGCTTTC GAGTTCATCC AGCGTCTCCC GGTTCGCCTC 6840

GAGTTGCTCC TCCTGCATCT CCAGCAGGTG GCGGCCCACG TCGTCCAGGC TCCGCACGGC 6900

CTTGCCCATC ACCAGCGCCG TGACGAGGTT GGCCCCGTTC AAGACCATCT CGCCGTAGGT 6960 CACCGGCACG TCGGCCTCGG TGTCCTCCAC CTTCAGGAAG GACTGCAGGA GGCGCTGTTT 7020

GATGGCGGCG GTGGTGACCA GCACCCCGTC GACCGGCCGC CCGCGCGTGT CGGCGTGCGT 7080

CAGGCGGGGC ACGGCCACGG ACGGCTGCGT CGCCGTGGTC AGGTCCACGA GCCAGGCCTC 7140

GATGGCCTCG CGGCGATGGC CCGCCTTGCC CAGGAAGAAG CTCGTGTCGC AAAAGCTCCG 7200

CTTCAGCTCG GCGACCAGGG TCGCCCGGGC GACCCTGGTC GCCAGGCGCC CGTTGTCGAG 7260 ATATCGTTGC ATGGGCAACA GCAGGGCCAG GGGAGGCGCC TTCTCCAACA GCACGTGCAG 7320

CATCTGGTCG GCCGTGCCGC GCTCAAACGC CCCCAGGACG GCCTGGACGT TGCGCGCGAG 7380

CTGCTGGATG GCGCGCAGCT GGCGATGCAG GCTAATGCCC GTCCCGTCCA GGGCCTCCCC 7440

CGTGAGCAGG GCAATGGCCT CGGTGGCCAG GCTGAAGGCG GCGTTCAGGG CCCGGCGGTC 7500

GATGACCTTC GTCATGTAAT TATGCACGGG CTGCTCGACG GGGTGCGGGC CGTCGCGGGC 7560 GATGAGGGGC TGGTGGACCT CGAACTGCAC ACGCCCTTCG TTCATGTAAG CCAGCTCCGG 7620

GAACTTGGTG CACACGCACG CCACGGACAG GCCGAGCTCC AGAAAGCGCA CGAGCGACAG 7680

GGTGTTGCAG TAGGACCCCA GCAGGGCGTC AAACTCTACG TCATACAGGC TGTTTTCGTC 7740

GGAGCGCACG CGGGCGAAAA AATCAAAGAG TCTGCGGTGG GACGCCACCT CGATCGTACT 7800

CAGGATGGAG CCGGTGGGCA CCATGGCCGC GGCGTACCGG TAACCCGGGG GGTCGCGGGC 7860 AGGAGCGGCC ATTGGGTTCC TTGGGGGATT CGCAGGCTCC ATCAAGCCAA GCTCGGGAAG 7920

GCCAAGCCCC TCCCACACAA CGCCTCACCG CCGGCGGACG CGACTAACAA CCCACGGGCC 7980

GCCAAAAACC CCAAGGGGCA ACCCGACCAA CAACAGGCGA GGGGAGGAAA GGCGTAAAGG 8040

GGGCGTTGGG AGGCAAAAAG AAAGAAAACA CCCAGACGTA GGCCCGAGGA CCGGCCGGCG 8100 TCCTCTGTCC CCGAGCACCC ACTGTGCCCA ACAGGCACGG GGGCGAGCTG CCCCTGCCTT 8160

ATATACCCCC CCGCCACACC CCCGTTAGAA CGCGACGGGT GCCTTCAAGA TGGCCCTGGT 8220

CCAAAAGCGT GCTAGAAAAA AGTTGGTAAA GGCGGCAAAG CAGTCCGCCG CCGCCACCCA 8280

CATGGCGGCG CCGGCCGCGC AGGCGATTCC CAGAGAACGG GCGCGGAGGG GATCCGTGCG 8340 GGGCAGCAGC TGGCTGGCGG TGATCCAATG GAAAAGCCCG TCGGGACTGA ACGTCTCATG 8400

GGCGGCCGCC ACCAGGGCGC ACAGGGCCGC GCCGCCCATG ATCACGCACA ACCCCCAAAA 8460

CACGGGTGGC GACAACGGCA GGCGATCCCG TTTGATGTTC ACGTACAGGA GGAGCGCCCG 8520

TGCCAGCCAC GTGACATAGT AGGCGAGGAC GGCGGCTATA ATACATGCCG GCGCCACCGC 8580

CCGTCCGGTC CACCCGTAAT ACATGCCCGC GGCCACCAGC TCCAGCGGCT TGAGGACCAG 8640 GAACGACCAA GCAAACATCA CCACCCGCTT GGAAAAGACC GGCTGGGTGT GGGGCGGAAG 8700

ACGCGAGTAG GCCGAACTGA CAAAAAAATC AGACGTGCCG TACGAGGACA GCGAAAACTG 8760

TTCATCGAGC GGCAGTTCGC CGTCCTCCCC GCCACACGCG GCCTCGTATA CCAGCTCGCG 8820

ATCCAACAAA GGAACATCAT CCCGCATTGT CATGGTCGGT GCGGGGAGCC GGCGAGGCAG 8880

CGAAACCGAA AGTAGTGCTG GCGGCGCGGG CCCGGGTCCG GACCCAAGCT TCAGGGATGG 8940 GGGGCGGAGG CCAAAATCAA ACAAGCACCG CGCGGGTTCT ACACACAACC CCCACCCGGG 9000

TAGTATCCGC GGATGCGAGT GCCTGGCGAA GTCACGTCCC AGCAGGATAT AAACCTCGGC 9060

CGTTGGGCCC GGAACCCCCG AAATTCACAC CCACGCCCTG ACGCCCAAAT CATGGGTGGA 9120

TGTGGTTCGC GAGCCGCACA TCCGTGCGTC CGCCCTCCCC CGCGGGCTGA TGACGTGGCG 9180

GTTAGTCAGT GGGAAGGCAG GGGGAAAGAT GGGTTGGGGG AGGAAACGAA GAAAACACCC 9240 AGAGGGCCAC GTCGGGAATG CGCCCGGAGT TGTCCTTAAA AGGCCGGCCG TGCGTGACGG 9300

AAGCCGTCGT TTGCCCAAGC ACCGACGCCG CGATCCACAG TGGGGGGAGT TCCTCCGTCC 9360

GGCCACAACC CTACGCGCGG GCGGCACGCG CGAGAGCAAC CCACGGGTCC CGTTCGCGCC 9420

ACCGCCAGCC CTTGCTCCCA CCACCCTCCT CCCACCACCC CACTATTCCC CCCCCCCCAA 9480

GTCCGCCCCG TGGCTCGCCG GCCATGGAGC TCAGCTATGC CACCACCCTG CACCACCGGG 9540 ACGTTGTGTT TTACGTCACG GCAGACAGAA ACCGCGCCTA CTTTGTGTGC GGGGGGTCCG 9600

TTTATTCCGT AGGGCGGCCT CGGGATTCTC AGCCGGGGGA AATTGCCAAG TTTGGCCTGG 9660

TGGTCCGGGG GACAGGCCCC AAAGACCGCA TGGTCGCCAA CTACGTACGA AGCGAGCTCC 9720

GCCAGCGCGG CCTGCGGGAC GTGCGGCCCG TGGGGGAGGA CGAGGTGTTC CTGGACAGCG 9780

TGTGTCTGCT AAACCCGAAC GTGAGCTCCG AGCGAGACGT GATTAATACC AACGACGTTG 9840 AAGTGCTGGA CGAATGCCTG GCCGAATACT GCACCTCGCT GCGAACCAGC CCGGGGGTGC 9900

TGGTGACCGG GGTGCGCGTG CGCGCGCGAG ACAGGGTCAT CGAGCTATTT GAGCACCCGG 9960

CGATCGTCAA CATTTCCTCG CGCTTCGCGT ACACCCCCTC CCCCTACGTA TTCGCCCTGG 10020

CCCAGGCGCA CCTCCCCCGG CTCCCGAGCT CGCTGGAGCC CCTGGTGAGC GGCCTGTTTG 10080

ACGGCATTCC CGCCCCGCGC CAGCCCCTGG ACGCCCGCGA CCGGCGCACG GATGTCGTGA 10140 TCACGGGCAC CCGCGCCCCC AGACCGATGG CCGGGACCGG GGCCGGGGGC GCGGGGGCCA 10200

AGCGGGCCAC CGTCAGCGAG TTCGTGCAAG TGAAGCACAT CGACCGTGTT GTGTCCCCGA 10260

GCGTCTCTTC CGCCCCCCCG CCGAGCGCCC CCGACGCGAG TCTGCCGCCC CCGGGGCTCC 10320

AGGAGGCCGC CCCGCCGGGC CCCCCGCTCA GGGAGCTGTG GTGGGTGTTC TACGCCGGCG 10380

ACCGGGCGCT GGAGGAGCCC CACGCCGAGT CGGGATTGAC GCGCGAGGAG GTCCGCGCCG 10440 TGCATGGGTT CCGGGAGCAG GCGTGGAAGC TGTTTGGGTC GGTGGGGGCT CCGCGGGCGT 10500

TTCTCGGGGC CGCGCTGGCC CTGAGCCCGA CCCAAAAGCT CGCCGTCTAC TACTATCTCA 10560

TCCACCGGGA GCGGCGCATG TCCCCCTTCC CCGCGCTCGT GCGGCTCGTC GGTCGGTACA 10620

TCCAGCGCCA CGGCCTGTAC GTTCCCGCGC CCGACGAACC GACGTTGGCC GATGCCATGA 10680 ACGGGCTGTT CCGCGACGCG CTGGCGGCCG GGACCGTGGC CGAGCAGCTC CTCATGTTCG 10740

ACCTCCTCCC GCCCAAGGAC GTGCCGGTGG GGAGCGACGC GCGGGCCGAC AGCGCCGCCC 10800

TGCTGCGCTT TGTGGACTCG CAACGCCTGA CCCCGGGGGG GTCCGTCTCG CCCGAGCACG 10860

TCATGTACCT CGGCGCGTTC CTGGGCGTGT TGTACGCCGG CCACGGACGC CTGGCCGCGG 10920 CCACGCATAC CGCGCGCCTG ACGGGCGTGA CGTCCCTGGT CCTGACCGTG GGGGACGTCG 10980

ACCGGATGTC CGCGTTTGAC CGCGGGCCGG CGGGGGCGGC TGGCCGCACG CGAACCGCCG 11040

GGTACCTGGA CGCGCTGCTT ACCGTTTGCC TGGCTCGCGC CCAGCACGGC CAGTCTGTGT 11100

GAGATATCCC AATAAAGTGC AGTCGTTTTC TAACCCACGG ATGCCGTTGT ATGCCTATAC 11160

GGGGGACTAT GGGGGGGGGG GGAAAGGAAA GGAAACAGGA ATGGAGAAGG GAAAGGAACA 11220 GAGGCGGTAG CGGACGCACG GCGGACACAA TAACAAACAG ACCGCGGACA CGGAGGGAGT 11280

CGGTTGGGTT GGGCGTGGAC GCCGCTGCGT CCACACACCC GTTTATTCGC GTCTCCACAA 11340

AAATGGGACG CACGTTCGGA CCACCCTGAG GATGCCCGCC AGGGCCGCGG TGATCATAAC 11400

GACCCCCAGC GCGGACGCGG CCAGAAACCC GGGGGCGATG GTGGCGATGG GCAGCGTGTC 11460

AAAGGCCAGC AGATGAATCA CAGTTCCGTT GGGGAACAAC AACAGGGCCA CGGACGGCAC 11520 GTCGCTGGAA AACACGTTCG GGGTGCCCGC CACCGGCCCC TGGGCCAGCT GCTGTTGGGT 11580

GGCATCCGTG TCCACCAGCA GCACCGACAT GACCTCCCCG GCCGGGGTGT AGCGCAGAAA 11640

CACGGCCCCC ACGAGGCCGA GGTCGCGCCG GTTTTCGGTG CGCACCAGCC GCTTCGGCTC 11700

AATCTCCCGC GCGTGCCCTT CGCAGGTGGC GGTGAGATAG GTGATAAACA GCGGGCGGCG 11760

GACGTCAACG CCCGTAAGCT TGTATCCGAT CCCGCGGGGC AAGGGGGTGT GGGTGACGAC 11820 GTAGCTGGCG TTGTGGGTGA TGGGCACGAG GATCCGGGGC TCCGCGTTGT GCGACGGGCC 11880

GCTACACTGG TGGGTGGCCT CCGGGACGAA GGCGCGGATC AGGGCGTTGT AGTGCGCCCA 11940

GCGCGTGAGA ACGGAGGCCA CGCCGCGGGT CTGTTGTGCC ATGACGTCCG CCGGGATGTC 12000

GGATCGGGTG GCCATGGCCA GCGCGTCCAG GATGAACCCG CCCTCGGCGA GATCGAAGCG 12060

CAGGGAAGCT GCGCATGGGG AAAAGTGGTC CGGGAGCCAG AAGAGGTTTT TCTGGTGGTC 12120 GGTCCTGGCT AGCGCGGCCC GGAGATCGGC GTGGGTCGCC GCGGCGACGT CGGACGTACA 12180

CAGGGCCGTG GTTATGAGGA GGCCCCGGCG GGCGCGTTCC CGCTGCTCGG CCGAGGGCGC 12240

GCCCGCCAGG AACGGCGCCC GGAGGACGGC CGTGGCGTAA AACAGCGCTC GGCGGACCAT 12300

CGGGGCGGTT AGCGCGCGGC CGCCGAGAAA CTCGGCGTAC AGGGCGTCGA TCAGGCGGGC 12360

CGCGCTCGGG GCCACCGCGC CATAGGCCGC GGGGCTGTCC AACACGAACG CCAGCTGATA 12420 GCCCAGCGCG TGCGCCGCCA GGCTCTGCTC TCGCTCGAGG ATCGCGGCCA CCAGATGCCC 12480

GAGGCGCGCC TCCAGCCGCA GGCGGGCCGC CGGGTCCAAC ACGGACACGT TCAGGAACAC 12540

CGAGTCGGCC GCGCAGCCCG CTGCTCCCCG GGCGGCCAGG CCGGCCAGCA CGCGCGAGTG 12600

GGCCAAAAAG CCCAGCAGGT CGGAGAGGCG AATCGCGTCG TGGGCGTGGG CCGCGTTGAC 12660

GAACGCAAAC CCCGACGAGG CGAGCAGCCC CGCGAGGCGC CAGAACAGGG ACGGACGCGC 12720 GTCCGTGCCG GAGCCCGGGT CCTCCCCCAA AAACTCCGCA TAGGCCCGCG ACATATACTG 12780

GGCGTAGTTC GTGCTCTCCT CGGGGTAGCC GGCCACCCGC CGGAGGGCGT CCAGCGCCGA 12840

GCCGTTGTCG GCGGGCGTCG GGGCCCCCAG GACAAAGACG CGATACCTGG GGCCGGCCGG 12900

AGGCCCGGGG AGCACCGCGG GGGCGTTTTC GTCGGTCGGA TTTCCGACCC GAGCGAGGGT 12960

CTTGTCCGCA GGCACCACTA TGATCTCGGC CGGAGGGCTG TCCCGCATCG ATATCACGAG 13020 CCCCATGAAG CCCTTCCCGT ATCGCGCGCG CACGAGCGCG GCGTCGCACC CGAACGCCAG 13080

CCCGCCCGTC GTCCAGACGC CCACGGGCCA CGTCGAGGCC GACGGGGAGA GGTACACGTA 13140

CCGACCCGGA GTCCGTAGCA GGCCCCTGGC GGCCAGCCAG GTCACGGATG CGTTGTGCAG 13200

ATGCGCGATG CTCAGGTTCG TCGTCGGATG CCTCGGTGTC CCCGCGGGCG GCCCCGGGGG 13260 CGGCGCGTTG CGTCGGCCGT CCGGGTGCCT CTCGGTCGCC CCGTCGTCTC CCCGCGGGAA 13320

CGTAAGCCCC TCGCGGTCCG GCGCGGCCGC GAATGTTACC CAGGCCCGGG ACCGCAACAG 13380

CGCGGAGGCG CCGGGGTTGT GCGACAGTCC CTTGAGCTGG GTCACCTCGG CGGGGGGACG 13440

GGACGTGGGC CCCGCCTCGG GGAGCTCGGG CAGGCTCGCG TTCCGAGGCC GGCCGAGCAG 13500 ATAGGTCTTT GGGATGTAAA GCAGCTGCCC GGGGTCCCGA GGAAACTCGG CCGTGGTGAC 13560

CAACACGAAA CAAAAGCGCT CGGCGTACCA CCGAAGCATG GGCACGGATG CCGTAGTCAG 13620

GTTGAGTTCG CCCGGGGGCG CCAAGCGTCC GCGCTGGGGG TCGCTGGCGT CGGGGGTGTT 13680

GGGCAACCAC AGACGCCCGG TGTTTGTGTC GCGCCAGTAC GTGCGGGCCA ACCCCAGACC 13740

GTGCAAAAAC CACGGGTCGA TTTGCTCCGT CCAGTACGTG TCATGGCCCC CGGCAACGCC 13800 CACCAGGACC CCCATCACCA CCCACAGACC GGGGCCCATG GTCGTCCGTC CCGGCTGCCA 13860

GTCCGCAGAT GGGGGGGTGT CCGTACCCAC GGCCCAAAGA GGCTCCGCAC CTCGGAGGCT 13920

ATCGGAGGCC CTTTGTTGCC GTAAGCGCGG GCCAAAGGAT GGGGTGGGGT GAGGGTAAAA 13980

GCACAAAGGG AGTACCAGAC CGAAAACAAG GACGGATCGG CCCGCTCCGT TTTTCGGTGG 14040

GGTGCTGATA CGGTGCCAGC CCTGGCCCCG AACCCCCGCG CTTATGGACA CACCACACGA 14100 CAACAATGCC TTTTATTCTG TTCTTTTATT GCCGTCATCG CCGGGAGGCC TTCCGTTCGG 14160

GCTTCCGTGT TTGAACTAAA CTCCCCCCAC CTCGCGGGCA AACGTGCGCG CCAGGTCGCG 14220

TATCTCGGCG ATGGACCCGG CGGTTGTGAC GCGGGTTGGG ATCATCCCGG CGGTGAGGCG 14280

CAACAGGGCG TCTCGACACC CGACGGGCGA CTGATCGTAA TCCAGGACAA ATAGATGCAT 14340

CGGAAGGAGG CGGTCGGCCA AGACGTCCAA GACCCAGGCA AAAATGTGGT ACAAGTCCCC 14400 GTTGGGGGCC AGCAGCTCGG GAACGCGGAA CAGGGCAAAC AGCGTGTCCT CGATGCGGGG 14460

CAGAGACCCC GCGCCGTCCT CGGGGTCGGG GCGCGGGGTC GCCGCGGCGA CCCCCGTCAG 14520

CCGGCCCCAG TCCTCCCGCC ACCTCCCGCC GCGCTGCAGG TACCGCACCG TGTTGGCGAG 14580

TAGATCGTAG ACACGGCGAA TGGCGGACAG CATGGCCAGG TCAAGCCGCT CGCCCGGGCG 14640

TTGGCGTCTG GCCAGGCGGT CGGCGTGTTC GGCCTCCGGA AGGACACCCA GGACCAGGTT 14700 CGTGCCGGGC GCGGTCGGGG GCATGAGGGC CACGAACGCC AACACGGCCT GGGGGGTCAT 14760

GCTTCCCATG AGGTACCGCG CGGCCGGGTA GCACAGCAGG GAGGCGATAG GGTGCCGGTC 14820

GAAAACAAGG GTGAGGGCCG GGGGCGGGGC TTGCGGGCCC ACAGCCTCCC CCCCGATATG 14880

AGGAGCCAAA ACGGCGTCCG TCGCCGCATA AGGCGTGCTC ATTGTTATCT GGGCGCTGGT 14940

CATTACCACC GCCGCCTCCC CGGCCGATAT CTCGCCGCGG TCCAGACGGT GCTGCGTGTT 15000 GTAGATGTTC GTCAGGGTCT CGGAGGCCCC CAGCACCTGC CAGTAAGTCA TCGGCTCGGG 15060

GACGTAGACG ATATTGTCGC GCGGCCCCAG GGCCTCCATC AGCTGCGCGG AGGTGGTGGT 15120

CTTCCCCACC CCGTGGGGTC CGTCTATATA AACCCGCAGC AGCGTGGGCA GCTCCGGATC 15180

CCCGCGGGCT TCGGAGGCCC CCTGGCGATG GCTAGGACGG GACGCCGCGC GGCCGTCGGT 15240

AGGCCCGCTC GCACGAGCAG CCTGACCGAA CGCAGGCGCG TGCTGTTGGC CGGCGTGAGA 15300 AGCCATACCC GCTTCTACAA GGCGTTCGCC CGAGAGGTGC GGGAGTTCAA CGCCACCAGG 15360

ATTTGTGGAA CGCTGCTGAC GCTGATGAGC GGGTCGCTGC AGGGTCGCTC GCTGTTCGAG 15420

GCCACGCGCG TCACCTTAAT ATGCGAAGTG GACCTCGGGC CGCGCCGCCC AGACTGCATC 15480

TGCGTGTTCG AATTCGCCAA TGACAAAACG TTGGGAGGTG TGTGCGTCAT CCTGGAGCTA 15540

AAGACATGCA AATCGATTTC TTCCGGGGAC ACGGCCAGCA AACGCGAACA GCGGACCACG 15600 GGCATGAAGC AGCTGCGCCA CTCCCTGAAG CTGCTGCAGT CGCTCGCGCC TCCGGGGGAC 15660

AAGGTCGTCT ACCTGTGTCC TATTTTGGTG TTTGTCGCGC AGCGTACGCT GCGCGTCAGC 15720

CGCGTGACCC GGCTCGTCCC GCAAAAGATC TCCGGCAACA TCACCGCGGC CGTGCGGATG 15780

CTCCAAAGCC TGTCCACGTA TGCCGTGCCG CCGGAACCGC AGACCCGGCG GTCGCGGCGC 15840 CGGGTCGCCG CGACCGCCAG ACCGCAAAGG CCCCCCTCCC CGACACGTGA CCCGGAAGGC 15900

ACGGCGGGTC ATCCGGCCCC ACCAGAGAGC GACCCCCCCT CCCCAGGGGT CGTAGGCGTC 15960

GCTGCGGAGG GTGGGGGTGT GCTTCAGAAA ATCGCGGCGC TTTTTTGCGT GCCGGTGGCC 16020

GCCAAGAGCA GACCCCGGAC CAAAACCGAG TGAGGTTCTG TGTGTTGTTT TTTTTCCTCG 16080 TTTTGTTTTC TCTTCTTTCC CCCCCCCCTC CCCCGCTTCT GGCCAAGCAT CCTCACCTGC 16140

TTAAGCGGAA CCCGCGGGCG CGCGGGGACT CATTTGTCGC CGGCGACACC CACCCGACAA 16200

CAGCCCCTGG GTGTAGACCG CTGTCGCCCC CGTCTGTCGC CTCTCCCTTT TTTCCCCCCC 16260

TCAAAGAACG TGGTGTTGGG CGCCGGCCAA TTCTTCCCGG AGCGCCGTCG TCGCCCGCCC 16320

GCCGCCCTCG AACATGGACC CGTACTACCC TTTCGACGCG CTGGACGTTT GGGAACACAG 16380 GCGCTTCATC GTCGCCGACT CCAGGAGCTT CATCACCCCC GAGTTCCCCC GGGACTTCTG 16440

GATGTTGCCC GTGTTCAACA TCCCCCGGGA GACGGCGGCG GAGCGGGCGG CAGTGCTGCA 16500

GGCCCAGCGC ACCGCGGCCG CGGCGGCCCT GGAGAACGCC GCCCTCCAGG CCGCCGAGCT 16560

GCCCGTCGAC ATCGAGCGCC GGATACGCCC GATCGAGCAG CAGGTGCATC ACATCGCCGA 16620

CGCCCTGGAG GCGCTGGAGA CCGCGGCGGC CGCGGCCGAA GAGGCGGATG CCGCGCGGGA 16680 CGCCGAGGCG AGGGGGGAGG GCGCTGCGGA CGGGGCAGCG CCGTCGCCCA CCGCGGGCCC 16740

CGCCGCCGCG GAGATGGAGG TTCAGATCGT ACGCAACGAC CCGCCGCTAC GATACGATAC 16800

CAACCTCCCC GTGGATCTGC TACACATGGT GTACGCGGGC CGCGGGGCCG CGGGTTCGTC 16860

GGGAGTCGTC TTTGGTACCT GGTACCGCAC GATCCAGGAA CGCACCATCG CGGACTTCCC 16920

CCTGACCACC CGCAGCGCCG ACTTTCGAGA CGGGCGCATG TCCAAGACCT TCATGACCGC 16980 GCTGGTCCTG TCTCTGCAGT CGTGCGGCCG GCTGTACGTG GGCCAGCGCC ACTATTCCGC 17040

CTTCGAGTGC GCCGTGCTGT GTCTGTATCT GCTGTACCGA ACCACCCACG AGTCCTCCCC 17100

CGATCGCGAT CGCGCTCCCG TTGCGTTCGG GGACCTGCTG GCCCGCCTGC CGCGCTACCT 17160

GGCGCGTCTG GCCGCGGTAA TCGGCGACGA GAGCGGACGC CCGCAGTACC GCTACCGCGA 17220

CGACAAGCTG CCCAAAGCGC AGTTCGCGGC GGCCGGCGGC CGCTACGAGC ACGGGGCCCT 17280 GGCCACCCAC GTCGTGATCG CCACGTTGGT GCGCCACGGG GTGCTACCGG CGGCCCCGGG 17340

CGACGTTCCC CGAGACACCA GCACCCGCGT GAACCCCGAC GACGTGGCCC ACCGCGACGA 17400

CGTCAACCGC GCCGCCGCCG CGTTTTTGGC ACGCGGCCAC AACCTCTTCC TGTGGGAGGA 17460

CCAGACGCTG CTGCGGGCGA CCGCCAACAC CATTACGGCC CTGGCCGTGC TTCGGCGGCT 17520

CCTCGCGAAC GGCAACGTGT ACGCGGACCG CCTCGACAAC CGCCTGCAGC TGGGCATGCT 17580 GATCCCGGGA GCCGTCCCGG CGGAGGCCAT CGCTCGGGGG GCGTCCGGAT TGGACTCGGG 17640

CGCCATAAAA AGCGGCGACA ACAACCTGGA GGCGCTGTGC GTTAACTATG TACTTCCGCT 17700

GTATCAGGCA GACCCCACGG TCGAGCTGAC CCAGTTGTTT CCGGGGCTGG CCGCCCTGTG 17760

CCTGGACGCC CAGGCGGGGC GGCCACTGGC GTCGACGAGG CGCGTGGTGG ATATGTCGTC 17820

GGGCGCCCGC CAGGCGGCGC TCGTGCGCCT CACCGCGCTG GAGCTCATCA ACCGCACCCG 17880 CACAAACACC ACCCCTGTGG GGGAGATTAT TAACGCCCAC GATGCCTTGG GGATACAATA 17940

CGAACAGGGC CTGGGGCTGC TCGCCCAGCA GGCACGCATC GGCTTGGCGT CGAACGCCAA 18000

GCGATTCGCC ACGTTCAACG TGGGCAGCGA CTACGACCTG TTGTACTTTT TGTGTCTCGG 18060

GTTCATTCCC CAGTACCTGT CCGTGGCCTA GGGAAGGGTG GGGGTGGTGG TGGTGGGGTG 18120

TTTTTCTGCT GTTGTTGTTT CTGGTCCGCC TGGTCACAAA AGGCACGGCG CCCCGAAACG 18180 CGGGCTTTAG TCCCGGCCCG GACGTCGGCG GACACACAAC AACGGCGGGC CCCGTGGGTG 18240

GGTAAGTTGG TTCGGGGGCA TCGCTGTATT CCCTTGCCCG CTTCCACCCC CCCTTCCCGT 18300

TTTGTTTGTT TGTGCGGGTG CCCATGGCGT CGGCGGAAAT GCGCGAGCGG TTGGAGGCGC 18360

CTCTGCCCGA CCGGGCGGTG CCCATCTACG TGGCCGGGTT TTTGGCCCTG TACGACAGCG 18420 GGGACCCGGG CGAGCTGGCC CTGGACCCAG ACACGGTGCG TGCGGCCCTG CCTCCGGAGA 18480

ACCCCCTGCC GATCAACGTA GACCACCGCG CTCGGTGCGA GGTGGGCCGG GTGCTCGCCG 18540

TGGTCAACGA CCCTCGGGGG CCGTTTTTTG TGGGGCTGAT CGCGTGCGTG CAGCTGGAGC 18600

GCGTCCTCGA GACGGCCGCC AGCGCCGCTA TTTTTGAGCG CCGCGGACCC GCGCTCTCCC 18660 GGGAGGAGCG TCTGCTGTAC CTGATCACCA ACTACCTGCC ATCGGTCTCG CTGTCCACAA 18720

AACGCCGGGG GGACGAGGTT CCGCCCGACC GCACCCTGTT TGCGCACGTG GCCCTGTGCG 18780

CCATCGGGCG GCGCCTTGGA ACCATCGTCA CCTACGACAC CAGCCTAGAC GCGGCCATCG 18840

CTCCGTTTCG CCACCTGGAC CCGGCGACGC GCGAGGGGGT GCGACGCGAG GCCGCCGAGG 18900

CCGAGCTCGC GCTGGCCGGG CGCACCTGGG CCCCCGGCGT GGAGGCGCTC ACACACACGC 18960 TGCTCTCCAC CGCCGTCAAC AACATGATGC TGCGTGACCG CTGGAGCCTC GTGGCCGAGC 19020

GGCGGCGGCA GGCCGGGATC GCCGGACACA CGTACCTTCA GGCGAGCGAA AAATTTAAAA 19080

TATGGGGGGC GGAGTCTGCC CCTGCGCCGG AGCGCGGGTA TAAAACCGGC GCCCCGGGTG 19140

CCATGGACAC ATCCCCCGCC GCGAGCGTTC CCGCGCCGCA GGTCGCCGTC CGTGCGCGTC 19200

AAGTCGCGTC GTCGTCGTCT TCTTCTTCTT CTTTTCCGGC ACCGGCCGAT ATGAACCCCG 19260 TTTCGGCATC GGGCGCCCCG GCCCCTCCGC CGCCCGGCGA CGGGAGTTAT TTGTGGATCC 19320

CCGCCTTTCA TTACAATCAG CTCGTCACCG GGCAATCCGC GCCCCACCAC CCGCCGCTGA 19380

CCGCGTGCGG CCTGCCGGCC GCGGGGACGG TGGCCTACGG ACACCCCGGC GCCGGCCCGT 19440

CCCCGCACTA CCCGCCTCCT CCCGCCCACC CGTACCCGGG TATGCTGTTC GCGGGCCCCA 19500

GTCCCCTGGA GGCCCAGATC GCCGCGCTGG TGGGGGCCAT CGCCGCCGAC CGCCAGGCGG 19560 GTGGGCTTCC GGCGGCCGCC GGAGACCACG GGATCCGGGG GTCGGCGAAG CGCCGCCGAC 19620

ACGAGGTGGA GCAGCCGGAG TACGACTGCG GCCGTGACGA GCCGGACCGG GACTTCCCGT 19680

ATTACCCGGG CGAGGCCCGC CCCGAGCCGC GCCCGGTCGA CTCCCGGCGC GCCGCGCGCC 19740

AGGCTTCCGG GCCCCACGAA ACCATCACGG CGCTGGTGGG GGCGGTGACG TCCCTGCAGC 19800

AGGAACTGGC GCACATGCGC GCGCGTACCC ACGCCCCCTA CGGGCCGTAT CCGCCGGTGG 19860 GGCCCTACCA CCACCCCCAC GCAGACACGG AGACCCCCGC CCAACCACCC CGCTACCCCG 19920

CCGAGGCCGT CTATCTGCCG CCGCCGCACA TCGCCCCCCC GGGGCCTCCT CTATCCGGGG 19980

CGGTCCCCCC ACCCTCGTAT CCCCCAGTTG CGGTTACCCC CGGTCCCGCC CCCCCGCTAC 20040

ATCAGCCCTC CCCCGCACAC GCCCACCCCC CTCCGCCGCC GCCGGGACCC ACGCCTCCCC 20100

CCGCCGCGAG CTTACCCCAA CCCGAGGCGC CCGGCGCGGA GGCCGGCGCC TTAGTTAACG 20160 CCAGCAGCGC GGCCCACGTG AACGTGGACA CGGCCCGGGC CGCCGATCTG TTTGTGTCAC 20220

AGATGATGGG GTCCCGCTAA CTCGCCTCCA GGATCCGGAC TTGGGGGGGG TGTGTGTTTT 20280

CATATATTTT AAATAAACAA ACAACCGGAC AAAAGTATAC CCACTTCGTG TGCTTGTGTT 20340

TTTGTTTGAG AGGGGGGGGG TGGAGTGGGG GGGAAAGTGG GCCGAAT 20388

(2) INFORMATION FOR SEQ ID NO: 144:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 262 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 144:

Met Asn Ala His Phe Ala Asn Glu Val Gin Tyr Asp Leu Thr Arg Asp 1 5 10 15

Pro Ser Ser Pro Ala Ser Leu Ile His Val Ile Ile Ser Ser Glu Cys

20 25 30

Leu Ala Ala Ala Gly Val Pro Leu Ser Ala Leu Val Arg Gly Arg Pro 35 40 45 Asp Gly Gly Ala Ala Ala Asn Phe Arg Val Glu Thr Gin Thr Arg Ala 50 55 60

His Ala Thr Gly Asp Cys Thr Pro Trp Arg Ser Ala Phe Ala Ala Tyr 65 70 75 80

Val Pro Ala Asp Ala Val Gly Ala Ile Leu Ala Pro Val Ile Pro Ala 85 90 95

His Pro Asp Leu Leu Pro Arg Val Pro Ser Ala Gly Gly Leu Phe Val

100 105 110

Ser Leu Pro Val Ala Cys Asp Ala Gin Gly Val Tyr Asp Pro Tyr Thr 115 120 125 Val Ala Ala Leu Arg Leu Ala Trp Gly Pro Trp Ala Thr Cys Ala Arg 130 135 140

Val Leu Leu Phe Ser Tyr Asp Glu Leu Val Pro Pro Asn Thr Arg Tyr 145 150 155 160

Ala Ala Asp Gly Ala Arg Leu Met Arg Leu Cys Arg His Phe Cys Arg 165 170 175

Tyr Val Ala Arg Leu Gly Ala Ala Ala Pro Ala Ala Ala Thr Glu Ala

180 185 190

Ala Ala His Leu Ser Leu Gly Met Gly Glu Ser Gly Thr Pro Thr Pro 195 200 205 Gin Ala Ser Ser Val Ser Gly Gly Ala Gly Pro Ala Val Val Gly Thr 210 215 220

Pro Asp Pro Pro Ile Ser Pro Glu Glu Gin Leu Thr Ala Pro Gly Gly 225 230 235 240

Asp Thr Ala Thr Ala Glu Asp Val Ser Ile Thr Gin Glu Asn Glu Glu 245 250 255

Ile Xaa Xaa Xaa Xaa Xaa 260

(2) INFORMATION FOR SEQ ID NO: 145:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 423 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 145:

Val Pro Glu Gly Ala Trp Val Gly Gly Ala Cys Ala Arg Pro Arg Gly 1 5 10 15 Pro Arg Ala His Val Arg Leu Tyr Ala Val Cys Phe Val Cys Pro Gin 20 25 30

Gly Ile Arg Gly Gin Asp Phe Asn Leu Leu Phe Val Asp Glu Ala Asn

35 40 45

Phe Ile Arg Pro Asp Ala Val Gin Thr Ile Met Gly Phe Leu Asn Gin 50 55 60

Ala Asn Cys Lys Ile Ile Phe Val Ser Ser Thr Asn Thr Gly Lys Ala 65 70 75 80

Ser Thr Ser Phe Leu Tyr Asn Leu Arg Gly Ala Ala Asp Glu Leu Leu 85 90 95 Asn Val Val Thr Tyr Ile Cys Asp Asp His Met Pro Arg Val Val Thr 100 105 110

His Thr Asn Ala Thr Ala Cys Ser Cys Tyr Ile Leu Asn Lys Pro Val

115 120 125

Phe Ile Thr Met Asp Gly Ala Val Arg Arg Thr Ala Asp Leu Phe Leu 130 135 140

Pro Asp Ser Phe Met Gin Glu Ile Ile Gly Gly Gin Ala Arg Glu Thr

145 150 155 160

Gly Asp Asp Arg Pro Val Leu Thr Lys Ser Ala Gly Glu Arg Phe Leu

165 170 175 Leu Tyr Arg Pro Ser Thr Thr Thr Asn Ser Gly Leu Met Ala Pro Glu

180 185 190

Leu Tyr Val Tyr Val Asp Pro Ala Phe Thr Ala Asn Thr Arg Ala Ser

195 200 205

Gly Thr Gly Ile Ala Val Val Gly Arg Tyr Arg Asp Asp Phe Ile Ile 210 215 220

Phe Ala Leu Glu His Phe Phe Leu Arg Ala Leu Thr Gly Ser Ala Pro 225 230 235 240

Ala Asp Ile Ala Arg Cys Val Val His Ser Leu Ala Gin Val Leu Ala 245 250 255 Leu His Pro Gly Ala Phe Arg Ser Val Arg Val Ala Val Glu Gly Asn 260 265 270

Ser Ser Gin Asp Ser Ala Val Ala Ile Ala Thr His Val His Thr Glu 275 280 285 Met His Arg Ile Leu Ala Ser Ala Gly Ala Asn Gly Pro Gly Pro Glu

290 295 300

Leu Leu Phe Tyr His Cys Glu- Pro Pro Gly Gly Ala Val Leu Tyr Pro 305 310 315 320 Phe Phe Leu Leu Asn Lys Gin Lys Thr Pro Ala Phe Glu Tyr Phe Ile

325 330 335

Lys Lys Phe Asn Ser Gly Gly Val Met Ala Ser Gin Glu Leu Val Ser

340 345 350

Val Thr Val Arg Leu Gin Thr Asp Pro Val Glu Tyr Leu Ser Glu Gin 355 360 365

Leu Asn Asn Leu lie Glu Thr Val Ser Pro Asn Thr Asp Val Arg Met

370 375 380

Tyr Ser Gly Lys Arg Asn Gly Ala Ala Asp Asp Leu Met Val Ala Val 385 390 395 400 Ile Met Ala Ile Tyr Leu Ala Ala Pro Thr Gly Ile Pro Pro Ala Phe

405 410 415

Phe Pro Ile Thr Arg Thr Ser 420

(2) INFORMATION FOR SEQ ID NO: 146:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 355 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 146:

Val Leu Leu Ser Pro Ala Pro Pro Pro Leu Pro His Gly Arg Cys Pro

1 5 10 15

Pro Ser Leu Phe His His Arg Pro Gly Cys Val Ser Gly Pro Pro Ala 20 25 30

Pro Pro Arg Ser Gly Val Ser Arg Pro Gly Ala Met Ile Thr Asp Cys

35 40 45

Phe Glu Ala Asp Ile Ala Ile Pro Ser Gly Ile Ser Arg Pro Asp Ala 50 55 60 Ala Ala Leu Gin Arg Cys Glu Gly Arg Val Val Phe Leu Pro Thr Ile 65 70 75 80

Arg Arg Gin Leu Ala Asp Val Ala His Glu Ser Phe Val Ser Gly Gly 85 90 95 Val Ser Pro Asp Thr Leu Gly Leu Leu Leu Ala Tyr Arg Arg Arg Phe

100 105 110

Pro Ala Val Ile Thr Arg Val -Leu Pro Thr Arg Ile Val Ala Cys Pro 115 120 125 Val Asp Leu Gly Leu Thr His Ala Gly Thr Val Asn Leu Arg Asn Thr 130 135 140

Ser Pro Val Asp Leu Cys Asn Gly Asp Pro Val Ser Leu Val Pro Pro 145 150 155 160

Val Phe Glu Gly Gin Ala Thr Asp Val Arg Leu Glu Ser Leu Asp Leu 165 170 175

Thr Leu Arg Phe Pro Val Pro Leu Pro Thr Pro Leu Ala Arg Glu Ile

180 185 190

Val Ala Arg Leu Val Arg Ile Arg Asp Leu Asn Pro Asp Pro Arg Thr 195 200 205 Pro Gly Glu Leu Pro Asp Leu Asn Val Leu Tyr Tyr Asn Gly Ala Arg 210 215 220

Leu Ser Leu Val Ala Asp Val Gin Gin Leu Ala Ser Val Asn Thr Glu 225 230 235 240

Leu Arg Ser Leu Val Leu Asn Met Val Tyr Ser Ile Thr Glu Gly Thr 245 250 255

Thr Leu Ile Leu Thr Leu Ile Pro Arg Leu Leu Ala Leu Ser Ala Gin

260 265 270

Asp Gly Tyr Val Asn Ala Leu Leu Gin Met Gin Ser Val Thr Arg Glu 275 280 285 Ala Ala Gin Leu Ile His Pro Glu Ala Pro Met Leu Met Gin Asp Gly 290 295 300

Glu Arg Arg Leu Pro Leu Tyr Glu Ala Leu Val Ala Trp Leu Ala His 305 310 315 320

Ala Gly Gin Leu Gly Asp Ile Leu Ala Pro Ala Val Arg Val Cys Thr 325 330 335

Phe Asp Gly Ala Ala Val Val Gin Ser Gly Asp Met Ala Pro Val Ile

340 345 350

Arg Tyr Pro 355

(2) INFORMATION FOR SEQ ID NO: 147:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1382 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 147:

Val Trp Glu Gly Leu Gly Leu Pro Glu Leu Gly Leu Met Glu Pro Ala 1 5 10 15

Asn Pro Pro Arg Asn Pro Met Ala Ala Pro Ala Arg Asp Pro Pro Gly

20 25 30

Tyr Arg Tyr Ala Ala Ala Met Val Pro Thr Gly Ser Ile Leu Ser Thr 35 40 45

Ile Glu Val Ala Ser His Arg Arg Leu Phe Asp Phe Phe Ala Arg Val

50 55 60

Arg Ser Asp Glu Asn Ser Leu Tyr Asp Val Glu Phe Asp Ala Leu Leu 65 70 75 80 Gly Ser Tyr Cys Asn Thr Leu Ser Leu Val Arg Phe Leu Glu Leu Gly

85 90 95

Leu Ser Val Ala Cys Val Cys Thr Lys Phe Pro Glu Leu Ala Tyr Met

100 105 110

Asn Glu Gly Arg Val Gin Phe Glu Val His Gin Pro Leu Ile Ala Arg 115 120 125

Asp Gly Pro His Pro Val Glu Gin Pro Val His Asn Tyr Met Thr Lys

130 135 140

Val Ile Asp Arg Arg Ala Leu Asn Ala Ala Phe Ser Leu Ala Thr Glu 145 150 155 160 Ala Ile Ala Leu Leu Thr Gly Glu Ala Leu Asp Gly Thr Gly Ile Ser

165 170 175

Leu His Arg Gin Leu Arg Ala Ile Gin Gin Leu Ala Arg Asn Val Gin

180 185 190

Ala Val Leu Gly Ala Phe Glu Arg Gly Thr Ala Asp Gin Met Leu His 195 200 205

Val Leu Leu Glu Lys Ala Pro Pro Leu Ala Leu Leu Leu Pro Met Gin

210 215 220

Arg Tyr Leu Asp Asn Gly Arg Leu Ala Thr Arg Val Ala Arg Ala Thr 225 230 235 240 Leu Val Ala Glu Leu Lys Arg Ser Phe Cys Asp Thr Ser Phe Phe Leu

245 250 255

Gly Lys Ala Gly His Arg Arg Glu Ala Ile Glu Ala Trp Leu Val Asp

260 265 270

Leu Thr Thr Ala Thr Gin Pro Ser Val Ala Val Pro Arg Leu Thr His 275 280 285

Ala Asp Thr Arg Gly Arg Pro Val Asp Gly Val Leu Val Thr Thr Ala

290 295 300

Ala Ile Lys Gin Arg Leu Leu Gin Ser Phe Leu Lys Val Glu Asp Thr 305 310 315 320

Glu Ala Asp Val Pro Val Thr Tyr Gly Glu Met Val Leu Asn Gly Ala

325 - 330 335

Asn Leu Val Thr Ala Leu Val Met Gly Lys Ala Val Arg Ser Leu Asp 340 345 350

Asp Val Gly Arg His Leu Leu Glu Met Gin Glu Glu Gin Leu Glu Ala

355 360 365

Asn Arg Glu Thr Leu Asp Glu Leu Glu Ser Ala Pro Gin Thr Thr Arg

370 375 380 Val Arg Ala Asp Leu Val Ala Ile Gly Asp Arg Leu Val Phe Leu Glu

385 390 395 400

Ala Leu Glu Lys Arg Ile Tyr Ala Ala Thr Asn Val Pro Tyr Pro Leu

405 410 415

Val Gly Ala Met Asp Leu Thr Phe Val Leu Pro Leu Gly Leu Phe Asn 420 425 430

Pro Ala Met Glu Arg Phe Ala Ala His Ala Gly Asp Leu Val Pro Ala

435 440 445

Pro Gly His Pro Glu Pro Arg Ala Phe Pro Pro Arg Gin Leu Phe Phe

450 455 460 Trp Gly Lys Asp His Gin Val Leu Arg Leu Ser Met Glu Asn Ala Val

465 470 475 480

Gly Thr Val Cys His Pro Ser Leu Met Asn Ile Asp Ala Ala Val Gly

485 490 495

Gly Val Asn His Asp Pro Val Glu Ala Ala Asn Pro Tyr Gly Ala Tyr 500 505 510

Val Ala Ala Pro Ala Gly Pro Gly Ala Asp Met Gin Gin Arg Phe Leu

515 520 525

Asn Ala Trp Arg Gin Arg Leu Ala His Gly Arg Val Arg Trp Val Ala

530 535 540 Glu Cys Gin Met Thr Ala Glu Gin Phe Met Gin Pro Asp Asn Ala Asn

545 550 555 560

Leu Ala Leu Glu Leu His Pro Ala Phe Asp Phe Phe Ala Gly Val Ala

565 570 575

Asp Val Glu Leu Pro Gly Gly Glu Val Pro Pro Ala Gly Pro Gly Ala 580 585 590

Ile Gin Ala Thr Trp Arg Val Val Asn Gly Asn Leu Pro Leu Ala Leu

595 600 605

Cys Pro Val Ala Phe Arg Asp Arg Leu Glu Leu Gly Val Gly Arg His 610 615 620 Ala Met Ala Pro Ala Thr Ile Ala Ala Val Arg Gly Ala Phe Glu Asp 625 630 635 640

Arg Ser Tyr Pro Ala Val Phe Tyr Leu Leu Gin Ala Ala Ile His Gly 645 650 655 Ser Glu His Val Phe Cys Ala Arg Leu Val Thr Gin Cys Ile Thr Ser

660 665 670

Tyr Trp Asn Asn Thr Arg Cys -Ala Ala Phe Val Asn Asp Tyr Ser Leu 675 680 685 Val Ser Tyr Ile Val Thr Tyr Leu Gly Gly Asp Leu Pro Glu Glu Cys 690 695 700

Met Ala Val Tyr Arg Asp Leu Val Ala His Val Glu Ala Gin Leu Val 705 710 715 720

Asp Asp Phe Thr Leu Pro Gly Pro Glu Leu Gly Gly Gin Ala Gin Ala 725 730 735

Glu Leu Asn His Leu Met Arg Asp Pro Ala Leu Leu Pro Pro Leu Val

740 745 750

Trp Asp Cys Asp Gly Leu Met Arg His Ala Ala Leu Asp Arg His Arg 755 760 765 Asp Cys Arg Ile Asp Ala Gly Gly His Glu Pro Val Tyr Ala Ala Ala 770 775 780

Cys Asn Val Ala Thr Ala Asp Phe Asn Arg Asn Asp Gly Arg Leu Leu 785 790 795 800

His Asn Thr Gin Ala Arg Ala Ala Asp Ala Ala Asp Asp Arg Pro His 805 810 815

Arg Pro Ala Asp Trp Thr Val His His Lys Ile Tyr Tyr Tyr Val Leu

820 825 830

Val Pro Ala Phe Ser Arg Gly Arg Cys Cys Thr Ala Gly Val Arg Phe 835 840 845 Asp Arg Val Tyr Ala Thr Leu Gin Asn Met Val Val Pro Glu Ile Ala 850 855 860

Pro Gly Glu Glu Cys Pro Ser Asp Pro Val Thr Asp Pro Ala His Pro 865 870 875 880

Leu His Pro Ala Asn Leu Val Ala Asn Thr Val Asn Ala Met Phe His 885 890 895

Asn Gly Arg Val Val Val Asp Gly Pro Ala Met Leu Thr Leu Gin Val

900 905 910

Leu Ala His Asn Met Ala Glu Arg Thr Thr Ala Leu Leu Cys Ser Ala 915 920 925 Ala Pro Asp Ala Gly Ala Asn Thr Ala Ser Thr Ala Asn Met Arg Ile 930 935 940

Phe Asp Gly Ala Leu His Ala Gly Val Leu Leu Met Ala Pro Gin His 945 950 955 960

Leu Asp His Thr Ile Gin Asn Gly Glu Tyr Phe Tyr Val Leu Pro Val 965 970 975

His Ala Leu Phe Ala Gly Ala Asp His Val Ala Asn Ala Pro Asn Phe

980 985 990

Pro Pro Ala Leu Arg Asp Leu Ala Arg His Val Pro Leu Val Pro Pro 995 1000 1005

Ala Leu Gly Ala Asn Tyr Phe Ser Ser Ile Arg Gin Pro Val Val Gin

1010 1015 1020

His Ala Arg Glu Ser Ala Ala Gly Glu Asn Ala Leu Thr Tyr Ala Leu 1025 1030 1035 104

Met Ala Gly Tyr Phe Lys Met Ser Pro Val Tyr His Gin Leu Lys Thr

1045 1050 1055

Gly Leu His Pro Gly Phe Gly Phe Thr Val Val Arg Gin Asp Arg Phe 1060 1065 1070 Val Thr Glu Asn Val Leu Phe Ser Ala Ser Glu Ala Tyr Phe Leu Gly 1075 1080 1085

Gin Leu Gin Val Ala Arg His Glu Thr Gly Gly Gly Val Ser Phe Thr

1090 1095 1100

Leu Thr Gin Pro Arg Gly Asn Val Asp Leu Gly Val Gly Tyr Thr Ala 1105 1110 1115 112

Val Ala Ala Thr Ala Thr Val Arg Asn Pro Val Thr Asp Met Gly Asn

1125 1130 1135

Leu Pro Gin Asn Phe Tyr Leu Gly Arg Gly Ala Pro Pro Leu Leu Asp 1140 1145 1150 Asn Ala Ala Ala Val Tyr Leu Arg Asn Ala Val Val Ala Gly Asn Arg 1155 1160 1165

Leu Gly Pro Ala Gin Pro Leu Pro Val Phe Gly Cys Ala Gin Val Pro

1170 1175 1180

Arg Arg Ala Gly Met Asp His Gly Gin Asp Ala Val Cys Glu Phe Ile 1185 1190 1195 120

Ala Thr Pro Val Ala Thr Asp Ile Asn Tyr Phe Arg Arg Pro Cys Asn

1205 1210 1215

Pro Arg Gly Arg Ala Ala Gly Gly Val Tyr Ala Gly Asp Lys Glu Gly 1220 1225 1230 Asp Val Ile Ala Leu Met Tyr Asp His Gly Gin Ser Asp Pro Ala Arg 1235 1240 1245

Pro Phe Ala Ala Thr Ala Asn Pro Trp Ala Ser Gin Arg Phe Ser Tyr

1250 1255 1260

Gly Asp Leu Leu Tyr Asn Gly Ala Tyr His Leu Asn Gly Asp Val Leu 1265 1270 1275 128

Ser Pro Cys Phe Lys Phe Phe Thr Ala Ala Asp Ile Thr Ala Lys His

1285 1290 1295

Arg Cys Leu Glu Arg Leu Ile Val Glu Thr Gly Ser Ala Val Ser Thr 1300 1305 1310 Ala Thr Ala Ala Ser Asp Val Gin Phe Lys Arg Pro Pro Gly Cys Arg 1315 1320 1325

Glu Leu Val Glu Asp Pro Cys Gly Leu Phe Gin Glu Ala Tyr Pro Ile 1330 1335 1340 Thr Cys Ala Ser Asp Pro Ala Leu Leu Arg Ser Ala Arg Asp Gly Glu 1345 1350 1355 136

Ala His Ala Arg Glu Thr His- Phe Thr Gin Tyr Leu Ile Tyr Asp Asp 1365 1370 1375 Leu Lys Gly Leu Ser Leu 1380

(2) INFORMATION FOR SEQ ID NO: 148:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 222 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 148:

Met Thr Met Arg Asp Asp Val Pro Leu Leu Asp Arg Glu Leu Val Tyr 1 5 10 15

Glu Ala Ala Cys Gly Gly Glu Asp Gly Glu Leu Pro Leu Asp Glu Gin

20 25 30

Phe Ser Leu Ser Ser Tyr Gly Thr Ser Asp Phe Phe Val Ser Ser Ala 35 40 45

Tyr Ser Arg Leu Pro Pro His Thr Gin Pro Val Phe Ser Lys Arg Val

50 55 60

Val Met Phe Ala Trp Ser Phe Leu Val Leu Lys Pro Leu Glu Leu Val 65 70 75 80 Ala Ala Gly Met Tyr Tyr Gly Trp Thr Gly Arg Ala Val Ala Pro Ala

85 90 95

Cys Ile Ile Ala Ala Val Leu Ala Tyr Tyr Val Thr Trp Leu Ala Arg

100 105 110

Ala Leu Leu Leu Tyr Val Asn Ile Lys Arg Asp Arg Leu Pro Leu Ser 115 120 125

Pro Pro Val Phe Trp Gly Leu Cys Val Ile Met Gly Gly Ala Ala Leu

130 135 140

Cys Ala Leu Val Ala Ala Ala His Glu Thr Phe Ser Pro Asp Gly Leu 145 150 155 160 Phe His Trp Ile Thr Ala Ser Gin Leu Leu Pro Arg Thr Asp Pro Leu

165 170 175

Arg Ala Arg Ser Leu Gly Ile Ala Cys Ala Ala Gly Ala Ala Met Trp 180 185 190 Val Ala Ala Ala Asp Cys Phe Ala Ala Phe Thr Asn Phe Phe Leu Ala

195 200 205

Arg Phe Trp Thr Arg Ala He- Leu Lys Ala Pro Val Ala Phe 210 215 220

(2) INFORMATION FOR SEQ ID NO: 149:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 627 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 149:

Val Gly Arg Gin Gly Glu Arg Trp Val Gly Gly Gly Asn Glu Glu Asn 1 5 10 15 Thr Gin Arg Ala Thr Ser Gly Met Arg Pro Glu Leu Ser Leu Lys Gly 20 25 30

Arg Pro Cys Val Thr Glu Ala Val Val Cys Pro Ser Thr Asp Ala Ala

35 40 45

Ile His Ser Gly Gly Ser Ser Ser Val Arg Pro Gin Pro Tyr Ala Arg 50 55 60

Ala Ala Arg Ala Arg Ala Thr His Gly Ser Arg Ser Arg His Arg Gin 65 70 75 80

Pro Leu Leu Pro Pro Pro Ser Ser His His Pro Thr Ile Pro Pro Pro 85 90 95 Pro Ser Pro Pro Arg Gly Ser Pro Ala Met Glu Leu Ser Tyr Ala Thr 100 105 110

Thr Leu His His Arg Asp Val Val Phe Tyr Val Thr Ala Asp Arg Asn

115 120 125

Arg Ala Tyr Phe Val Cys Gly Gly Ser Val Tyr Ser Val Gly Arg Pro 130 135 140

Arg Asp Ser Gin Pro Gly Glu Ile Ala Lys Phe Gly Leu Val Val Arg 145 150 155 160

Gly Thr Gly Pro Lys Asp Arg Met Val Ala Asn Tyr Val Arg Ser Glu 165 170 175 Leu Arg Gin Arg Gly Leu Arg Asp Val Arg Pro Val Gly Glu Asp Glu 180 185 190

Val Phe Leu Asp Ser Val Cys Leu Leu Asn Pro Asn Val Ser Ser Asp 195 200 205 Val Ile Asn Thr Asn Asp Val Glu Val Leu Asp Glu Cys Leu Ala Glu

210 215 220

Tyr Cys Thr Ser Leu Arg Thr Ser Pro Gly Val Leu Val Thr Gly Val 225 230 235 240 Arg Val Arg Ala Arg Asp Arg Val Ile Glu Leu Phe Glu His Pro Ala

245 250 255

Ile Val Asn Ile Ser Ser Arg Phe Ala Tyr Thr Pro Ser Pro Tyr Val

260 265 270

Phe Ala Gin Ala His Leu Pro Arg Leu Pro Ser Ser Leu Glu Pro Leu 275 280 285

Val Ser Gly Leu Phe Asp Gly Ile Pro Ala Pro Arg Gin Pro Leu Asp

290 295 300

Ala Arg Asp Arg Arg Thr Asp Val Val Ile Thr Gly Thr Arg Ala Pro 305 310 315 320 Arg Pro Met Ala Gly Thr Gly Ala Gly Gly Ala Gly Ala Lys Arg Ala

325 330 335

Thr Val Ser Glu Phe Val Gin Val Lys His Ile Asp Arg Val Val Ser

340 345 350

Pro Ser Val Ser Ser Ala Pro Pro Pro Ser Ala Pro Asp Ala Ser Leu 355 360 365

Pro Pro Pro Gly Leu Gin Glu Ala Ala Pro Pro Gly Pro Pro Leu Arg

370 375 380

Glu Leu Trp Trp Val Phe Tyr Ala Gly Asp Arg Ala Leu Glu Glu Pro 385 390 395 400 His Ala Glu Ser Gly Leu Thr Arg Glu Glu Val Arg Ala Val His Gly

405 410 415

Phe Arg Glu Gin Ala Trp Lys Leu Phe Gly Ser Val Gly Ala Pro Arg

420 425 430

Ala Phe Leu Gly Ala Ala Leu Ser Pro Thr Gin Lys Leu Ala Val Tyr 435 440 445

Tyr Tyr Leu Ile His Arg Glu Arg Arg Met Ser Pro Phe Pro Ala Leu

450 455 460

Val Arg Leu Val Gly Arg Tyr Ile Gin Arg His Gly Val Pro Ala Pro 465 470 475 480 Asp Glu Pro Thr Leu Ala Asp Ala Met Asn Gly Leu Phe Arg Asp Ala

485 490 495

Ala Gly Thr Val Ala Glu Gin Leu Leu Met Phe Asp Leu Leu Pro Pro

500 505 510

Lys Asp Val Pro Val Gly Ser Asp Ala Arg Ala Asp Ser Ala Ala Leu 515 520 525

Leu Arg Phe Val Asp Ser Gin Arg Leu Thr Pro Gly Gly Ser Val Ser

530 535 540

Pro Glu His Val Met Tyr Leu Gly Ala Phe Leu Gly Val Leu Tyr Ala 545 550 555 560

Gly His Gly Arg Leu Ala Ala Ala Thr His Thr Ala Arg Leu Thr Gly

565 ^" 570 575

Val Thr Ser Leu Val Leu Thr Val Gly Asp Val Asp Arg Met Ser Ala 580 585 590

Phe Asp Arg Gly Pro Ala Gly Ala Ala Gly Arg Thr Arg Thr Ala Gly

595 600 605

Tyr Leu Asp Ala Leu Leu Thr Val Cys Leu Ala Arg Ala Gin His Gly 610 615 620 Gin Ser Val 625

(2) INFORMATION FOR SEQ ID NO: 150:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 908 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 150:

Val Ser Ile Ser Ala Gly Val Arg Gly Gin Gly Trp His Arg Ile Ser 1 5 10 15

Thr Pro Pro Lys Asn Gly Ala Gly Arg Ser Val Leu Val Phe Gly Leu

20 25 30

Val Leu Pro Leu Cys Phe Tyr Pro His Pro Thr Pro Ser Phe Gly Pro 35 40 45

Arg Leu Arg Gin Gin Arg Ala Ser Asp Ser Leu Arg Gly Ala Glu Pro

50 55 60

Leu Trp Ala Val Gly Thr Asp Thr Pro Pro Ser Ala Asp Trp Gin Pro 65 70 75 80 Gly Arg Thr Thr Met Gly Pro Gly Leu Trp Val Val Met Gly Val Leu

85 90 95

Val Gly Val Ala Gly Gly His Asp Thr Tyr Trp Thr Glu Gin Ile Asp

100 105 110

Pro Trp Phe Leu His Gly Leu Gly Leu Ala Arg Thr Tyr Trp Arg Asp 115 120 125

Thr Asn Thr Gly Arg Leu Trp Leu Pro Asn Thr Pro Asp Ala Ser Asp

130 135 140

Pro Gin Arg Gly Arg Leu Ala Pro Pro Gly Glu Leu Asn Leu Thr Thr 145 150 155 160

Ala Ser Val Pro Met Leu Arg Trp Tyr Ala Glu Arg Phe Cys Phe Val

165 - 170 175

Leu Val Thr Thr Ala Glu Phe Pro Arg Asp Pro Gly Gin Leu Leu Tyr 180 185 190

Ile Pro Lys Thr Tyr Leu Leu Gly Arg Pro Arg Asn Ala Ser Leu Pro

195 200 205

Glu Leu Pro Glu Ala Gly Pro Thr Ser Arg Pro Pro Ala Glu Val Thr

210 215 220 Gin Leu Lys Gly Leu Ser His Asn Pro Gly Ala Ser Ala Leu Leu Arg

225 230 235 240

Ser Arg Ala Trp Val Thr Phe Ala Ala Ala Pro Asp Arg Glu Gly Leu

245 250 255

Thr Phe Pro Arg Gly Asp Asp Gly Ala Thr Glu Arg His Pro Asp Gly 260 265 270

Arg Arg Asn Ala Pro Pro Pro Gly Pro Pro Ala Gly Thr Pro Arg His

275 280 285

Pro Thr Thr Asn Leu Ser Ile Ala His Leu His Asn Ala Ser Val Thr

290 295 300 Trp Leu Ala Arg Leu Leu Arg Thr Pro Gly Arg Tyr Val Tyr Leu Ser

305 310 315 320

Pro Ser Ala Ser Thr Trp Pro Val Gly Val Trp Thr Thr Gly Gly Leu

325 330 335

Ala Phe Gly Cys Asp Ala Ala Leu Val Arg Ala Arg Tyr Gly Lys Gly 340 345 350

Phe Met Gly Leu Val Ile Ser Met Arg Asp Ser Pro Pro Ala Glu Ile

355 360 365

Ile Val Val Pro Ala Asp Lys Thr Leu Ala Arg Val Gly Asn Pro Thr

370 375 380 Asp Glu Asn Ala Pro Ala Val Leu Pro Gly Pro Pro Ala Gly Pro Arg

385 390 395 400

Tyr Arg Val Phe Val Leu Gly Ala Pro Thr Pro Ala Asp Asn Gly Ser

405 410 415

Ala Leu Asp Ala Leu Arg Arg Val Ala Gly Tyr Pro Glu Glu Ser Thr 420 425 430

Asn Tyr Ala Gin Tyr Met Ser Arg Ala Tyr Ala Glu Phe Leu Gly Glu

435 440 445

Asp Pro Gly Ser Gly Thr Asp Ala Arg Pro Ser Leu Phe Trp Arg Leu 450 455 460 Ala Gly Leu Leu Ala Ser Ser Gly Phe Ala Phe Val Asn Ala Ala His 465 470 475 480

Ala His Asp Ala Ile Arg Leu Ser Asp Leu Leu Gly Phe Leu Ala His 485 490 495 Ser Arg Val Leu Ala Gly Leu Ala Arg Ala Ala Gly Cys Ala Ala Asp

500 505 510

Ser Val Phe Leu Asn Val Ser -Val Leu Asp Pro Ala Ala Arg Leu Arg 515 520 525 Leu Glu Ala Arg Leu Gly His Leu Val Ala Ala Ile Arg Glu Gin Ser 530 535 540

Leu Ala Ala His Ala Leu Gly Tyr Gin Leu Ala Phe Val Leu Asp Ser 545 550 555 560

Pro Ala Ala Tyr Gly Ala Val Ala Pro Ser Ala Ala Arg Leu Ile Asp 565 570 575

Ala Leu Tyr Ala Glu Phe Leu Gly Gly Arg Ala Leu Thr Ala Pro Met

580 585 590

Val Arg Arg Ala Leu Phe Tyr Ala Thr Ala Val Leu Arg Ala Pro Phe 595 600 605 Leu Ala Gly Ala Pro Ser Ala Glu Gin Arg Glu Arg Ala Arg Arg Gly 610 615 620

Leu Leu Ile Thr Thr Ala Leu Cys Thr Ser Asp Val Ala Ala Ala Thr 625 630 635 640

His Ala Asp Leu Arg Ala Ala Arg Thr Asp His Gin Lys Asn Leu Phe 645 650 655

Trp Leu Pro Asp His Phe Ser Pro Cys Ala Ala Ser Leu Arg Phe Asp

660 665 670

Leu Ala Glu Gly Gly Phe Ile Leu Asp Ala Met Ala Thr Arg Ser Asp 675 680 685 Ile Pro Ala Asp Val Met Ala Gin Gin Thr Arg Gly Val Ala Ser Val 690 695 700

Leu Thr Arg Trp Ala His Tyr Asn Ala Leu Ile Arg Ala Phe Val Pro 705 710 715 720

Glu Ala Thr His Gin Cys Ser Gly Pro Ser His Asn Ala Glu Pro Arg 725 730 735

Ile Leu Val Pro Ile Thr His Asn Ala Ser Tyr Val Val Thr His Thr

740 745 750

Pro Leu Pro Arg Gly Ile Gly Tyr Lys Leu Thr Gly Val Asp Val Arg 755 760 765 Arg Pro Leu Phe Ile Thr Tyr Leu Thr Ala Thr Cys Glu Gly His Ala 770 775 780

Arg Glu Ile Glu Pro Lys Arg Leu Val Arg Thr Glu Asn Arg Arg Asp 785 790 795 800

Leu Gly Leu Val Gly Ala Val Phe Leu Arg Tyr Thr Pro Ala Gly Glu 805 810 815

Val Met Ser Val Leu Leu Val Asp Thr Asp Ala Thr Gin Gin Gin Leu

820 825 830

Ala Gin Gly Pro Val Ala Gly Thr Pro Asn Val Phe Ser Ser Asp Val 835 840 845

Pro Ser Val Leu Leu Phe Pro Asn Gly Thr Val Ile His Leu Leu Ala

850 855 860

Phe Asp Thr Leu Pro Ile Ala Thr Ile Ala Pro Gly Phe Leu Ala Ala 865 870 875 880

Ser Ala Leu Gly Val Val Met Ile Thr Ala Ala Gly Ile Leu Arg Val

885 890 895

Val Arg Thr Cys Val Pro Phe Leu Trp Arg Arg Glu 900 905

(2) INFORMATION FOR SEQ ID NO: 151:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 370 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 151

Met Ala Ser His Ala Gly Gin Gin His Ala Pro Ala Phe Gly Gin Ala

1 5 10 15

Ala Arg Ala Ser Gly Pro Thr Asp Gly Arg Ala Ala Ser Arg Pro Ser

20 25 30

His Arg Gin Gly Ala Ser Asp Pro Glu Leu Pro Thr Leu Leu Arg Val 35 40 45

Tyr Ile Asp Gly Pro His Gly Val Gly Lys Thr Thr Thr Ser Ala Gin

50 55 60

Leu Met Glu Ala Leu Gly Pro Arg Asp Asn Ile Val Tyr Val Pro Glu

65 70 75 80

Pro Met Thr Tyr Trp Gin Val Leu Gly Ala Ser Glu Thr Leu Thr Asn

85 90 95

Ile Tyr Asn Thr Gin His Arg Leu Asp Arg Gly Glu Ile Ser Ala Gly

100 105 110

Glu Ala Ala Val Val Met Thr Ser Ala Gin Ile Thr Met Ser Thr Pro 115 120 125

Tyr Ala Ala Thr Asp Ala Val Leu Ala Pro His Ile Gly Gly Glu Ala

130 135 140

Val Gly Pro Gin Ala Pro Pro Pro Ala Leu Thr Leu Val Phe Asp Arg

145 150 155 160

His Pro Ile Ala Ser Leu Leu Cys Tyr Pro Ala Ala Arg Tyr Leu Met 165 170 175

Gly Ser Met Thr Pro Gin Ala Val Leu Ala Phe Val Met Pro Pro Thr 180 185 190

Ala Pro Gly Thr Asn Leu Val Leu Gly Val Leu Pro Glu Ala Glu His 195 200 205

Ala Asp Arg Leu Ala Arg Arg Gin Arg Pro Gly Glu Arg Leu Asp Leu 210 215 220

Ala Met Leu Ser Ala Ile Arg Arg Val Tyr Asp Leu Leu Ala Asn Thr

225 230 235 240

Val Arg Tyr Leu Gin Arg Gly Gly Arg Trp Arg Glu Asp Trp Gly Arg

245 250 255

Leu Thr Gly Val Ala Ala Ala Thr Pro Arg Pro Asp Pro Glu Asp Gly 260 265 270

Ala Gly Ser Leu Pro Arg Ile Glu Asp Thr Leu Phe Ala Leu Phe Arg 275 280 285

Val Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu Tyr His Ile Phe Ala

290 295 300

Trp Val Leu Asp Val Leu Ala Asp Arg Leu Leu Pro Met His Leu Phe

305 310 315 320

Val Leu Asp Tyr Asp Gin Ser Pro Val Gly Cys Arg Asp Ala Leu Leu 325 330 335

Arg Leu Thr Ala Gly Met Ile Pro Thr Arg Val Thr Thr Ala Gly Ser 340 345 350

Ile Ala Glu Ile Arg Asp Leu Ala Arg Thr Phe Ala Arg Glu Val Gly 355 360 365

Gly Val 370

(2) INFORMATION FOR SEQ ID NO: 152:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 352 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 152:

Val Leu Arg Val Val Asp Val Arg Gin Gly Leu Gly Gly Pro Gin His

1 5 10 15

Leu Pro Val Ser His Arg Leu Gly Asp Val Asp Asp Ile Val Ala Arg 20 25 30

Pro Gin Gly Leu His Gin Leu Arg Gly Gly Gly Gly Leu Pro His Pro

35 -40 45

Val Gly Ser Val Tyr Ile Asn Pro Gin Gin Arg Gly Gin Leu Arg Ile 50 55 60

Pro Ala Gly Phe Gly Gly Pro Leu Ala Met Ala Arg Thr Gly Arg Arg 65 70 75 80

Ala Ala Val Gly Arg Pro Ala Arg Thr Ser Ser Leu Thr Glu Arg Arg 85 90 95 Arg Val Leu Leu Ala Gly Val Arg Ser His Thr Arg Phe Tyr Lys Ala 100 105 110

Phe Ala Arg Glu Val Arg Glu Phe Asn Ala Thr Arg Ile Cys Gly Thr

115 120 125

Leu Leu Thr Leu Met Ser Gly Ser Leu Gin Gly Arg Ser Leu Phe Glu 130 135 140

Ala Thr Arg Val Thr Leu Ile Cys Glu Val Asp Leu Gly Pro Arg Arg

145 150 155 160

Pro Asp Cys Ile Cys Val Phe Glu Phe Ala Asn Asp Lys Thr Leu Gly

165 170 175 Gly Val Cys Val Ile Leu Lys Thr Cys Lys Ser Ile Ser Ser Gly Asp

180 185 190

Thr Ala Ser Lys Arg Glu Gin Arg Thr Thr Gly Met Lys Gin Leu Arg

195 200 205

His Ser Leu Lys Leu Leu Gin Ser Leu Ala Pro Pro Gly Asp Lys Val 210 215 220

Val Tyr Leu Cys Pro Ile Leu Val Phe Val Ala Gin Arg Thr Leu Arg

225 230 235 240

Val Ser Arg Val Thr Arg Leu Val Pro Gin Lys Ile Ser Gly Asn Ile

245 250 255 Thr Ala Ala Val Arg Met Leu Gin Ser Leu Ser Thr Tyr Ala Val Pro

260 265 270

Pro Glu Pro Gin Thr Arg Arg Ser Arg Arg Arg Val Ala Ala Thr Ala

275 280 285

Arg Pro Gin Arg Pro Pro Ser Pro Thr Arg Asp Pro Glu Gly Thr Ala 290 295 300

Gly His Pro Ala Pro Pro Glu Ser Asp Pro Pro Ser Pro Gly Val Val

305 310 315 320

Gly Val Ala Ala Glu Gly Gly Gly Val Leu Gin Lys Ile Ala Ala Leu

325 330 335 Phe Cys Val Pro Val Ala Ala Lys Ser Arg Pro Arg Thr Lys Thr Glu

340 345 350

(2) INFORMATION FOR SEQ ID NO: 153: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 571 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 153:

Met Asp Pro Tyr Tyr Pro Phe Asp Ala Leu Asp Val Trp Glu His Arg

1 5 10 15

Arg Phe Ile Val Ala Asp Ser Arg Ser Phe Ile Thr Pro Glu Phe Pro 20 25 30

Arg Asp Phe Trp Met Leu Pro Val Phe Asn Ile Pro Arg Glu Thr Ala

35 40 45

Ala Glu Arg Ala Ala Val Leu Gin Ala Gin Arg Thr Ala Ala Ala Ala 50 55 60 Ala Leu Glu Asn Ala Ala Leu Gin Ala Ala Glu Leu Pro Val Asp lie 65 70 75 80

Glu Arg Arg Ile Arg Pro Ile Glu Gin Gin Val His His Ile Ala Asp

85 90 95

Ala Leu Glu Ala Leu Glu Thr Ala Ala Ala Ala Ala Glu Glu Ala Asp 100 105 110

Ala Ala Arg Asp Ala Glu Arg Glu Gly Ala Ala Asp Gly Ala Ala Pro

115 120 125

Ser Pro Thr Ala Gly Pro Ala Ala Ala Glu Met Glu Val Gin Ile Val

130 135 140 Arg Asn Asp Pro Pro Leu Arg Tyr Asp Thr Asn Leu Pro Val Asp Leu

145 150 155 160

Leu His Met Val Tyr Ala Gly Arg Gly Ala Ala Gly Ser Ser Gly Val

165 170 175

Val Phe Gly Thr Trp Tyr Arg Thr Ile Gin Glu Arg Thr Ile Ala Asp 180 185 190

Phe Pro Leu Thr Thr Arg Ser Ala Asp Phe Arg Asp Gly Arg Met Ser

195 200 205

Lys Thr Phe Met Thr Ala Leu Val Leu Ser Leu Gin Ser Cys Gly Arg 210 215 220 Leu Tyr Val Gly Gin Arg His Tyr Ser Ala Phe Glu Cys Ala Val Leu 225 230 235 240

Cys Leu Tyr Leu Leu Tyr Arg Thr Thr His Glu Ser Ser Pro Asp Arg 245 250 255 Asp Arg Ala Pro Val Ala Phe Gly Asp Leu Leu Ala Arg Leu Pro Arg

260 265 270

Tyr Leu Ala Arg Leu Ala Ala, Val Ile Gly Asp Glu Ser Gly Arg Pro 275 280 285 Gin Tyr Arg Tyr Arg Asp Asp Lys Leu Pro Lys Ala Gin Phe Ala Ala 290 295 300

Ala Gly Gly Arg Tyr Glu His Gly Ala Thr His Val Val Ile Ala Thr 305 310 315 320

Leu Val Arg His Gly Val Leu Pro Ala Ala Pro Gly Asp Val Pro Arg 325 330 335

Asp Thr Ser Thr Arg Val Asn Pro Asp Asp Val Ala His Arg Asp Asp

340 345 350

Val Asn Arg Ala Ala Ala Ala Phe Leu Arg His Asn Leu Phe Leu Trp 355 360 365 Glu Asp Gin Thr Leu Leu Arg Ala Thr Ala Asn Thr Ile Thr Ala Val 370 375 380

Leu Arg Arg Leu Leu Ala Asn Gly Asn Val Tyr Ala Asp Arg Leu Asp 385 390 395 400

Asn Arg Leu Gin Leu Gly Met Leu Ile Pro Gly Ala Val Pro Ala Glu 405 410 415

Ala Ile Arg Ala Ser Gly Leu Asp Ser Gly Ala Ile Lys Ser Gly Asp

420 425 430

Asn Asn Leu Glu Ala Leu Cys Val Asn Tyr Val Leu Pro Leu Tyr Gin 435 440 445 Ala Asp Pro Thr Val Glu Leu Thr Gin Leu Phe Pro Gly Leu Ala Ala 450 455 460

Leu Cys Leu Asp Ala Gin Ala Gly Arg Pro Leu Ala Ser Thr Arg Arg 465 470 475 480

Val Val Asp Met Ser Ser Gly Ala Arg Gin Ala Ala Leu Val Arg Leu 485 490 495

Thr Ala Leu Glu Leu Ile Asn Arg Thr Arg Thr Asn Thr Thr Pro Val

500 505 510

Gly Glu Ile Ile Asn Ala His Asp Ala Leu Gly Ile Gin Tyr Glu Gin 515 520 525 Gly Leu Gly Leu Leu Ala Gin Gin Ala Arg Ile Gin Ala Lys Arg Phe 530 535 540

Ala Thr Phe Asn Val Gly Ser Asp Tyr Asp Leu Leu Tyr Phe Leu Cys 545 550 555 560

Leu Gly Phe Ile Pro Gin Tyr Leu Ser Val Ala 565 570

(2) INFORMATION FOR SEQ ID NO: 154: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 571 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 154:

Met Asp Pro Tyr Tyr Pro Phe Asp Ala Leu Asp Val Trp Glu His Arg

1 5 10 15

Arg Phe Ile Val Ala Asp Ser Arg Ser Phe Ile Thr Pro Glu Phe Pro 20 25 30 Arg Asp Phe Trp Met Leu Pro Val Phe Asn Ile Pro Arg Glu Thr Ala 35 40 45

Ala Glu Arg Ala Ala Val Leu Gin Ala Gin Arg Thr Ala Ala Ala Ala

50 55 60

Ala Leu Glu Asn Ala Ala Leu Gin Ala Ala Glu Leu Pro Val Asp Ile 65 70 75 80

Glu Arg Arg Ile Arg Pro Ile Glu Gin Gin Val His His Ile Ala Asp

85 90 95

Ala Leu Glu Ala Leu Glu Thr Ala Ala Ala Ala Ala Glu Glu Ala Asp 100 105 110 Ala Ala Arg Asp Ala Glu Arg Glu Gly Ala Ala Asp Gly Ala Ala Pro 115 120 125

Ser Pro Thr Ala Gly Pro Ala Ala Ala Glu Met Glu Val Gin Ile Val

130 135 140

Arg Asn Asp Pro Pro Leu Arg Tyr Asp Thr Asn Leu Pro Val Asp Leu 145 150 155 160

Leu His Met Val Tyr Ala Gly Arg Gly Ala Ala Gly Ser Ser Gly Val

165 170 175

Val Phe Gly Thr Trp Tyr Arg Thr Ile Gin Glu Arg Thr Ile Ala Asp 180 185 190 Phe Pro Leu Thr Thr Arg Ser Ala Asp Phe Arg Asp Gly Arg Met Ser 195 200 205

Lys Thr Phe Met Thr Ala Leu Val Leu Ser Leu Gin Ser Cys Gly Arg

210 215 220

Leu Tyr Val Gly Gin Arg His Tyr Ser Ala Phe Glu Cys Ala Val Leu 225 230 235 240

Cys Leu Tyr Leu Leu Tyr Arg Thr Thr His Glu Ser Ser Pro Asp Arg

245 250 255

Asp Arg Ala Pro Val Ala Phe Gly Asp Leu Leu Ala Arg Leu Pro Arg 260 265 270

Tyr Leu Ala Arg Leu Ala Ala Val Ile Gly Asp Glu Ser Gly Arg Pro

275 - 280 285

Gin Tyr Arg Tyr Arg Asp Asp Lys Leu Pro Lys Ala Gin Phe Ala Ala 290 295 300

Ala Gly Gly Arg Tyr Glu His Gly Ala Thr His Val Val Ile Ala Thr

305 310 315 320

Leu Val Arg His Gly Val Leu Pro Ala Ala Pro Gly Asp Val Pro Arg

325 330 335 Asp Thr Ser Thr Arg Val Asn Pro Asp Asp Val Ala His Arg Asp Asp

340 345 350

Val Asn Arg Ala Ala Ala Ala Phe Leu Arg His Asn Leu Phe Leu Trp

355 360 365

Glu Asp Gin Thr Leu Leu Arg Ala Thr Ala Asn Thr Ile Thr Ala Val 370 375 380

Leu Arg Arg Leu Leu Ala Asn Gly Asn Val Tyr Ala Asp Arg Leu Asp

385 390 395 400

Asn Arg Leu Gin Leu Gly Met Leu Ile Pro Gly Ala Val Pro Ala Glu

405 410 415 Ala Ile Arg Ala Ser Gly Leu Asp Ser Gly Ala Ile Lys Ser Gly Asp

420 425 430

Asn Asn Leu Glu Ala Leu Cys Val Asn Tyr Val Leu Pro Leu Tyr Gin

435 440 445

Ala Asp Pro Thr Val Glu Leu Thr Gin Leu Phe Pro Gly Leu Ala Ala 450 455 460

Leu Cys Leu Asp Ala Gin Ala Gly Arg Pro Leu Ala Ser Thr Arg Arg

465 470 475 480

Val Val Asp Met Ser Ser Gly Ala Arg Gin Ala Ala Leu Val Arg Leu

485 490 495 Thr Ala Leu Glu Leu Ile Asn Arg Thr Arg Thr Asn Thr Thr Pro Val

500 505 510

Gly Glu Ile Ile Asn Ala His Asp Ala Leu Gly Ile Gin Tyr Glu Gin

515 520 525

Gly Leu Gly Leu Leu Ala Gin Gin Ala Arg Ile Gin Ala Lys Arg Phe 530 535 540

Ala Thr Phe Asn Val Gly Ser Asp Tyr Asp Leu Leu Tyr Phe Leu Cys 545 550 555 560

Leu Gly Phe Ile Pro Gin Tyr Leu Ser Val Ala 565 570

(2) INFORMATION FOR SEQ ID NO: 155:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11706 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 155:

GGACGAACCA ACGGACACCT CCGCAAAGCG CGCGCGCGCC TCCCCCGCGG CGTCGCGACA 60 GACCAGATAC AGCAGGGCGT GGAGGCAGTC GCGCGTGCGC GGGGGCAGCC ATACCGCGTA 120

TAGGGTAATG GCGCTGACGC TCTCCTCCAC CCAAACGATG CCGGGGGCTT CCATGCCACG 180

ACGCCCGGGG GTTGCCGTGT ATCGAACGAG CGCGGCCCCA GACTTATAGG GTGCTAAAGT 240

TCACCGCCCC CTGCATCATG GGCCAGGCCT CGGTGGGAAG CTCCGACAGA GCCGCCTCGA 300

GAATGATGTC AGTGTTGGGC TGGGCGCCGG AGGCGTGCGT GCGCAAGCAG CGCCCCCACG 360 CGGGCGCGCG CAGCTTGAAG CGCGCGCCCG CAAACTCCCG CTTATGGGCC ATCAGCAGCG 420

CGTACAGCTG TCTGTGCGTC CGGCAGGCGC TGTGGTCGAT GCGGTGGGCG TCCAGCAGCT 480

CCACGATGGC TCGCTTGGTG AGGTTTTTAA CGCGCCCCGC CCCGGGAAAC GTCTGCGTGC 540

TCTTGGCCAG CTGCACCCCG AACAGTTCGC CCCAGATGAT CTTGAACAGC GACAGCGCGT 600

GCTCCGTCTC GCTCACGGAC CCGCGCGGGG GGCAGCCGCT CAGGGCGTCG GCCACGCGCT 660 TAACCGCGTC CTCCGACAGC AAGGGGCCGT CGGTCACGTT ACAGTGGCCC AGTTCGAACA 720

CCAGCTGCAT GTAGCGGTCG TAGTGGGGGT TCAGCAGCTC CAGCACGTCC TCGGGGCTAA 780

AGGTTCGCCC CGACCCCCCG GCCATCGAGT CCCACTGCAG GCACGCGGCC ATGGTGCTGC 840

ACAGACGGAA CAGCTCCCAG ACGGGGGCGA CGTTTAGGGT GGGGTGTAGG GCCACAAGCT 900

CCAGCTCTCC GGCGGCGTTG ATCGTGGGGA TGACGCCCGT GGCGTAGTGG TCGTAAAGCC 960 GCCGGAAGAT GGCGCTGCTA TGGGCGGCCA TGGGGACGCG AAGACAGGCC TCCAGCAGCA 1020

CCAGGTAGAT GAACCGCGTG CGGCCGACCA GGCTGTTGAG GCCGCGCATG AGCGCGACCA 1080

CCTCGGCCGG CGCGACGTCC GGCCGGAGGT ACTTTTCGAC GAAAAGGCCC ACCTCCTCCG 1140

TCTCGGCGGC CTGGGCCGAC AGGGACGTGT CGGGGTCCTG GCAGCGCAGC TCCCGCAGAT 1200

CCCGCTGGGC CCTCAGGGCA TCAAAATGTA TCCCCCGCAA AAACAGACAA AAGTTCCTCG 1260 GGGTCAGCGC GGCGTCGTGG CCCCAGAACC GCACGTGCAT GCAGTTGAGG GTCAGAAGCA 1320

TGTGGAGGAT GTTAAGACTG TCCGCGAGGC ACGCCAGCGT GCACCTCTCG AAGTAGTGCT 1380

TGTACCGGAA TTTGCTGTAG ATGCGCGACC CCCGCGCCTG CGCCGCGTCG GCGTGCGACG 1440

CGTCGCAGCG CCCTTTGAAC CGGCGGCACA ACAGGTTCGT CACCTGGGAA AACTGTGCCG 1500

GCCACTGCCC GCTGGCGCTC ACCACGTGGT TGAGCAGCAT GGGCGTAAAG ACGGGCTCCG 1560 AGCGCGCCCC GGACCCGTCC ATGTAGATCA GCAGCTCCCC CTTGCGGAGA GTCCGTACCC 1620

GCCCCAGCGA CTGGTACACG GACACCATGT CCGGCCCGTA GTTCATGGGT TTCACGTAGG 1680

CGAACATGCT GTCAAAGTGC GGCGGATCGA AGCTAAGGCC CACCGTCACG ACCGTTGTGT 1740

AGATGACCAC CCGGTACCGG CCCCATGTGG TCACGTCGCC GGGCGGGGTG AGCGAGTGGA 1800

GCAGCAGCAC GCGGTCCGTA AACTGCCGGC AGAACCTGGC AACGACCTCC GCGAAGGAGA 1860 CCGTCGACGA GAAGATGCAG ACGTTATCTC CGCCGGCCAG GCGCGCCTCC AGCTCCCCGA 1920

AGAAGGTGGC GTCCGGGGGG GCGTCCGGGG GGGGCGCCCC GCCCGCCGGC CCCGGCGGGC 1980

GCAGGGCCGC CTGCAGGACC TCGGGCCCCA GGCGCGGGAG AAACAGACAA CGGCGCGCCG 2040

AAAATCCGGG CATGGCATAC TCCCCGATGA CCACGTGAAC GTTCTTTTCG CCCCGGAGGC 2100 TGCACAGAAA GTCCACCAGC TGCGCGTTGG CGGTGGCGTC CATGGCGATG ATCCGCGGGC 2160

ACGTGCGCAG CAGGCGCAGC ATCAACGCGT CGACGCGGCC CAGCTGCTGC ATCGTCGGCG 2220

AGTACAGTTG GCCCAACGTC GACATGACTT CGTCCAGGAC GAGCACGTCG TAGTTGTTCA 2280

ACAGGTTCGG GCCCACGCGA TGAAGACTTT CCACCTGCAC GATGAGACGG TGGAAGGGGC 2340 GGTCGTTCAT GATGTAATTG GTGGATGAGA AGTAGGTGAC GAAGTCGGGC AACCCTGACT 2400

CAGCGAACCG CGTCGCCAGG GTCTGAGTAA AACTCCGACG ACAGGAGACG ACCAGCACAC 2460

TCGTGTCCGG AGAGTGGATC GCTTCCCCCA ACCAGCGGAT CAGCGCGGTA GTTTTTCCCG 2520

AGCCCATTGG CGCGCGGACC ACAGTTACGC ACCGGGCCGT CGGGGCGCTC GCGTCCGGGA 2580

AGGTGACGGG TCCGTGTTGC TGCCGCTCGA TCGTTGTTTT CGGGTGGACC CGGGGAACCC 2640 ACTCGGCCAA ATCCCCCCCG TAAAGCATCC GCGCCAGCGA TACACTCGAC GTGTACTGCT 2700

CGCACTCGTC ATCCCCGATG GGACGCCGGG CCCCCAGGGG ATCCCCCGAG GCCGCGCCGG 2760

GCGCCGACGT CGCGCCCGGG GCGCGGGCGG CGTGGTGGGT CTGGTGTGTG CAGGTGGCGA 2820

CGTTCATCGT CTCGGCCATC TGCGTCGTGG GGCTCCTGGT GCTGGCCTCT GTGTTCCGGG 2880

ACAGGTTTCC CTGCCTTTAC GCCCCCGCGA CCTCTTATGC GGAGGCGAAC GCCACGGTCG 2940 AGGTGCGCGG GGGTGTAGCC GTCCCCCTCC GGTTGGACAC GCAGAGCCTG CTGGCCACGT 3000

ACGCAATTAC GTCTACGCTG TTGCTGGCGG CGGCCGTGTA CGCCGCGGTG GGCGCGGTGA 3060

CCTCGCGCTA CGAGCGCGCG CTGGATGCGG CCCGTCGCCT GGCGGCGGCC CGTATGGCGA 3120

TGCCACACGC CACGCTAATC GCCGGAAACG TCTGCGCGTG GCTGTTGCAG ATCACAGTCC 3180

TGCTGCTGGC CCACCGCATC AGCCAGCTGG CCCACCTTAT CTACGTCCTG CACTTTGCGT 3240 GCCTCGTGTA TCTCGCGGCC CATTTTTGCA CCAGGGGGGT CCTGAGCGGG ACGTACCTGC 3300

GTCAGGTTCA CGGCCTGATT GACCCGGCGC CGACGCACCA TCGTATCGTC GGTCCGGTGC 3360

GGGCAGTAAT GACAAACGCC TTATTACTGG GCACCCTCCT GTGCACGGCC GCCGCCGCGG 3420

TCTCGTTGAA CACGATCGCC GCCCTCAACT TCAACTTTTC CGCCCCGAGC ATGCTCATCT 3480

GCCTGACGAC GCTGTTCGCC CTGCTTGTCG TGTCGCTGTT GTTGGTGGTC GAGGGGGTGC 3540 TGTGTCACTA CGTGCGCGTG TTGGTGGGCC CCCACCTCGG GGCCATCGCC GCCACCGGCA 3600

TCGTCGGCCT GGCCTGCGAG CACTACCACA CCGGTGGCTA CTACGTGGTG GAGCAGCAGT 3660

GGCCGGGGGC CCAGACGGGA GTCCGCGTCG CCCTGGCGCT CGTCGCCGCC TTTGCCCTCG 3720

CCATGGCCGT GCTTCGGTGC ACGCGCGCCT ACCTGTATCA CCGGCGACAC CACACTAAAT 3780

TTTTCGTGCG CATGCGCGAC ACCCGGCACC GCGCCCATTC GGCGCTTCGA CGCGTACGCA 3840 GCTCCATGCG CGGTTCTAGG CGTGGCGGGC CGCCCGGAGA CCCGGGCTAC GCGGAAACCC 3900

CCTACGCGAG CGTGTCCCAC CACGCCGAGA TCGACCGGTA TGGGGATTCC GACGGGGACC 3960

CGATCTACGA CGAAGTGGCC CCCGACCACG AGGCCGAGCT CTACGCCCGA GTGCAACGCC 4020

CCGGGCCTGT GCCCGACGCC GAGCCCATTT ACGACACCGT GGAGGGGTAT GCGCCAAGGT 4080

CCGCGGGGGA GCCGGTGTAC AGCACCGTTC GGCGATGGTA GCCGTTTCGT TCGTTTTAAT 4140 AAACCGACGT TGTGCGTTTC ACCATACTTC GGCGCGCGCG TGTGTGTGTT TTTTTTGTGG 4200

TGTTTATTTT CCCCCACCCC TTCCTTTTCT TTCGGCCACC ACCCCCCTCC TCCCCCGTAC 4260

TATACAACAA AAAATACCAC ACATACGACC AAATACGGAC AATCATTTCT GTCTTTATTC 4320

GCTGTCAGAG AGTGGGGGCG TGAGCGTGGC AGGAGGGCGG GCCACGTCGG GGTCCCGCCG 4380

TCTGGTGTGA CGCGATGGGG GGTCCGATGC GCGCCGGTAC TGGGGCCCCG GCGCCCGGGT 4440 GACCACGCGC ATGTCGGGGG GCACGTAGAA GTTACCCTCT TCTTCGGACT CGATGTCCAC 4500

GACGTCAAAT TCGTGGGCGG TCAGCGAGAC GACCTCCCCG CCGTCGGTGA TGATGACGTT 4560

GTGTCGGCAG CAGCAGGGCC GCGCCCCGGA GAACGCGAGG CCCATAACTT GGCGAGCGTA 4620

TCGTCGAAGG CCAGGCGGCT GTTTCGCCGG ATGTCCCGGT AGATCCCCGG CTCGACGCGG 4680 ACGGGGGTGA TGATCAGGGC GATCGGAACG GCCTGGTCCG GGAGGATCGA TGCCTTGGCG 4740

GGTCCGGGGG CCCCGCCACG CCCGGCGGGC GCTCCGCGGC CGTCCTCCAG GCGGAACGTC 4800

ACGCCCTCCT CCGCGCCCGC GCGGTGCCTG CCGAGGAACG TCACCAGGTG CGGTTGCAGG 4860

GGGCAGTCGG GAAAGTGGCT GTCGAGGACG TATCCCTGCA CCAAGATCTG TTTGAAGTTC 4920 GGGTGGCGGG GGTTGGCGAA GATGGGCTCG CGGCGAACCA GCTCCCCGGA GCTCCAGGCC 4980

ACGGGAGAGA TGGTGCGACG CTCGAGGTCG GGGACGCCAA ACAGAAGCAC CTCCGAGACA 5040

ACGCCGCTAT TTAACTCCAC CAGCGCCCGA TCCGGGGCGG AGCATCGCCT TTTTTCGCCG 5100

GCGGCGCGGG AATCGAGCCA GTCCCGGTCT TGGGTGACGA GCGCCTCCTC CGGGCCCGGG 5160

ACGCGCCCGG GCGCGAAGTA GCGCACGCCG GGGTTGGGGA TGGACCGGAT GAACGCCCGG 5220 AACGCCTCCG GCGATCGCCG CGCCATCAGG TCCTCGTACG CGGAGGCCGC GGGGGCGCCG 5280

GGGTCCGCGG GGTCGAACGC GTACTTGGCT CGGCACTTAA CCTCGTAGAA GGCCAGGGGG 5340

GTCTGGGGGG CGGGGGCCAG GTAGCCGTGA GGGTCCCTGG GGCACACGAG GATGTCCAGG 5400

GACGCCCCCA CCATGCCCGT GTGGCCGTCC ATGAGGACCC CGCACGCGTG CACGTTCTCC 5460

TCGGCGAGGT CCCCGGGTTG GTGAAAGACG AAGCGCCCGG CGTCGGCGTC GTCGTTGACG 5520 CCCGCGTCCG CGCGGCCCAC GCAGTAGCGA AACAGCAGGT TTCGGGCCGT CGGCTCGTTC 5580

ACCCGCCCGA ACATCACCGC CGACGACTGG GCGTCCAGCC GCAGGCTGGC GTTGTGGGTG 5640

AGCCACTGGG ACGAGAAGCA CGGACCCTGC GCGCCCCACC GCAGCGTGGA GGCGGTCGTC 5700

AGGCCCCGCC GAAGCAGGGC CCAGAGCTGG CAGTCGGCCT GGTTTTGCGT CGCCGCCTCG 5760

TAAAATCCCA TAAGCGGGCG GGGGGCGACG GCTTCGGCGG CGGACGGGGG GGCGCGGCGC 5820 GTCAGGCGCC AGAGGTGCCG GCCGAGCCCG CGGTCCACCA TGCCGGCCGC CTCCAGCGAC 5880

ACGACGAGGG AGCACAGATA GTCCAGGCGA GCCCACAGGG GCCCGATGGC CAGAGGGGAG 5940

CGGACGCCGC GCAGCAGGCC GCGCAGGTGG CGCTCGAACG TTTCCGCCAA GATATGGGGG 6000

GGCAGTGCGT TGGGGATCGC CGACGCCGAC CACATCGGGT CGGGGTCCGG GGGACCGGGG 6060

CTGCAGTCCG GGTCGATGGC GTGTGCGCCC CCCGGCGAGA GGGGAATGTC GGGGGTTGGC 6120 GGGCCGGATG AGGCCTCAGA GAGGGCCGGG GACGCGGGCC GGGCCTTTTC GCCCGGGGCC 6180

CCGCCGTCGG GTTGCCCACG TGGGGGGCTC TGGGGCCAAT GGGAACCCGG GGCCCCCGGT 6240

GACGTGGGGC GGGGTGGGGC GGGGCGGGGC CCAAAGACGG TCGCCAGATC TAGGCTGTTG 6300

GGTCGGGGCC GCTTCGGGGG ACTATCGGGG TCGCGGGCGG GGTCCGCGGG GCGCTTGGCG 6360

CCGGGTGTTG CGGCGGCCGC CATTTTTACG AGCAGCCGAA GAGCTCGAGG GCGGAAGGGA 6420 TCCTCACGAC AGAGAGTGGC GCGCGGCCGG GTTGGCGTGA CAGAGGCGGG AGACCAGCAC 6480

CAGCAGCGGC CTCAGCTCGG GCGGCAGCGA CACCGACGAC AGGACGGCCT TGTGCGTGCG 6540

CTGGTAATTT ATACACTGCT CCGTGAACGC GCGCCGAATC TTGGGATTGC GAAGGTGGCG 6600

CCGGATGCCC TCCGGCACGT CATACGCCAG GCCGTGGGTG TTGGTCTCGG CCGAGTTGAC 6660

AAAGAGGGCG GGGTGCAGAA CGCAGCGATA GGCGAGGAGG GCCACGGCAA AGTCCGGCGA 6720 GAGCTGGTTG TTAAAGTACT GGTAGCCCGG GACGCGGGTC ACGGGGACGC CCAGGCTCGG 6780

GGCCACGTAC ACGCTAACCA GCAGCTCCAG CAGCGTCTGC CCCAGGGCGT AGAGATCGAC 6840

CGCCAGCCCG ACGTCGTGCT TCAGGGGGCG GTTGTTAAAC TCGGCCCGCT CGTTGTTGAG 6900

GTACTTTACC AAGAGCTCCG GCGGCTGGTT GTACCCGTGC CCCACCAGAG TGTGAAAGTT 6960

GGCCGTGGTC AGGGCGGCGG GCATCCCAAA CCCCCGGGGG GACTCGAGGT CCGGCTCCTG 7020 GAGGCAAAAC TGGCCCCGGG ATATCGTGGA GTTGGAGTTC AGGGTCACCA GGCTAAAGTC 7080

GGCCAGGACG GCCCGCCGGA GCGACACCGC GTCCGATCGC AGCATCACGA GGACGTTGGC 7140

GCACTTGATG TCCAGGTGGC TGATCCCGCA CCTGGTGTTC AGGAACACCA CGGCGCGCGC 7200

CAGGTCTGTG AAGCAGTGGT GGAGGGCCGT CGCGACGGAG GGGGTGGTCG CGCGCAGGGA 7260 CGCCAGCTGG CCGATGTACT TGCCGAGGTC CATGTCGTAC GCGGGGAACA CGATCTGGCG 7320

CTGCTGCAGC GAGAACCCGA GCGGGGTGAT AAAGCCGCGG ATGTCGTGGG TGCGGCCGCC 7380

GCGAAGAGCG CACTCCCCCA CGAGCAGGGT CGCGACGAGC TCCACGGCAA ACCACTCCTT 7440

TTCCCGGATG GTCTTCACGG CGAGCTTGTG TTCGCGAATC AACTGCACCT CGCCGTACCC 7500 CCCCGAGCCC CCGAAGCTGC GGGCCCCGGG GATCTCCAGG GTCGTGTAGC GGAGGGCGGG 7560

GTTGACGGCG AATACGGGGA TGCATAGCTT GTGGATGCGC GCGAGGGACA GGATGTGCGA 7620

GGGGGGCGAC GGGGGCGAGG TCATGGCCGT CTCGGACCTG CGCAGGGGCG GGCGCCTCAG 7680

CTTGGCCGCA GGGCCGGGGG CCTCGGGGGA CGAGCGGCGA CGAGACGAGC GGCTCACTCG 7740

CCATCGGGAC AGTCCCGCGC GAAGCCGCTC CCGGAAGCTG GATCGGCGGC GGGACCCGGG 7800 GCGGGCTCCG GAGACGGCGC CGTCTCGGGG GGAGGGGCCG CTTGGGCGTC CGGACGCCCG 7860

GCGGCTGAGG GAGTGTATGT AGGACGCGAG CCAGGCCTTG AAGGAGCGTC GGTGTGCACC 7920

TTGGGGGCTG ATGTCAGCTG CCACATGACT AGCAGGTCGC TGTCGCCCGG ACTCATCCAT 7980

CCGTCCGCCA GGTCGCCGTC CCCCCACAGA GACGCGTTCG CCGCGGCCTC TTCGAGCTGC 8040

TCCTCCTGGT CCGCAAGACG ATCGTCCGCC GCGTCCAGGC GCTCGCTAAG CGCGGGATCG 8100 AGGTACCGTC GGTGTGCGGT TAGAAAATCA CGTCGCGCCG CTTGCTCTTC CACGCGAATT 8160

TTAACACAGG TCGCTCGCTG TCGCATCATC TCTAAGCGCG CGCGGGACTT TAGCCGCGCC 8220

TCCAATTCCA AGTGGGCCGC CTTGGCGGCC ATAAAGGCGC CAACAAACCT AGGATCTTGT 8280

GTACTCACGC CCTCCCGGTG TAGCTGCAGG GTCTGGTCCC TGTACACCTC GGCCCGGAGG 8340

TGCGTCTCGG CCAAACGTCG GCGCAGGGCC GCGTGGCTGG CGTCTCGGCT CATCTCGCCG 8400 CCCCCGCGCG CGCCCGACGT CGGACTCCTT CGCCCCGACC CCCCTGACCT CAGCCGCCCC 8460

CGCCTCGCCC GCGATGTTTG GCCAGCAGCT GGCGTCCGAC GTGCAGCAGT ACCTGGAGCG 8520

CCTGGAGAAA CAGAGGCAAC AGAAGGTGGG CGTCGACGAG GCGTCGGCGG GCCTGACGCT 8580

CGGCGGCGAT GCGCTGCGCG TCCCTTTTTT GGATTTTGCC ACCGCGACGC CCAAGCGCCA 8640

CCAGACCGTG GTCCCGGGCG TCGGGACGCT CCACGACTGC TGCGAGCACT CGCCGCTCTT 8700 CTCGGCCGTC GCGCGGCGGT TGCTGTTTAA TAGCCTGGTG CCGGCGCAAC TCAGGGGGCG 8760

TGACTTTGGG GGCGACCACA CGGCCAAGCT GGAGTTCCTG GCCCCCGAGC TGGTGCGGGC 8820

GGTGGCGCGC CTGCGGTTTC GGGAGTGCGC GCCGGAGGAC GCCGTGCCCC AACGCAACGC 8880

CTACTACAGC GTCCTGAACA CGTTTCAGGC CCTGCACCGC TCCGAAGCCT TTCGGCAGTT 8940

GGTTCACTTC GTGCGGGACT TCGCCCAGTT GTTGAAAACC TCGTTCCGGG CCTCTAGTCT 9000 CGCGGAGACT ACGGGCCCCC CGAAGAAACG GGCCAAGGTG GACGTGGCCA CCCACGGGCA 9060

GACGTACGGC ACCTTGGAGC TCTTCCAGAA AATGATACTA ATGCACGCGA CCTACTTTCT 9120

GGCCGCCGTG CTGCTCGGGG ACCACGCGGA GCAGGTCAAC ACGTTCCTGC GGCTCGTGTT 9180

CGAGATCCCC CTGTTTAGCG ACACGGCCGT GCGGCACTTC CGCCAGCGCG CCACCGTGTT 9240

TCTAGTCCCC AGGCGCCACG GAAAGACCTG GTTTTTGGTG CCCCTCATCG CGCTGTCGCT 9300 CGCGTCCTTC CGGGGGATCA AGATAGGCTA CACGGCCCAC ATCCGCAAGG CGACCGAGCC 9360

CGTGTTTGAT GAGATCGACG CCTGCCTGCG GGGCTGGTTT GGCTCGTCCC GGGTGGACCA 9420

CGTCAAGGGG GAAACCATCT CGTTCTCGTT CCCGGACGGC TCGCGCAGCA CGATCGTGTT 9480

TGCCTCCAGC CACAACACGA ACGTAAGTAC GCCTTCCTCC CGCGGTGCCT GTTTCCCCGG 9540

TGCCGCCCTC CCCGAGATCG ACCGACAGAC AAACACAGCC AGACGCGAGT GTGGGACGAC 9600 ACGCCCGCAG CCCCCCCCGC CATGGCGGGG GGAAGCCTTA CTGTTTATTT GTAATCGGAC 9660

GATGAGGCTC TGGCCACGGC CCGCGCGACC GCGGGGCAGC TCGTTGCAAA CAGGCGGCTG 9720

GTATACGATG ACAGAACGCA GAGGCGCCAC CCGGCGCTGG TCGGGCGGAT GACGCTTTCC 9780

GCGCCGTCCC GGCCCACGAC GACCTCGTGC AGGTGGGCCG TGATGCGCGG GCGGCGGGTC 9840 GCCTGCCGCA GGATAACCGC GTCCACGGGG TGCCCGAAGA GGAGCTGACA CAGGCTCGCG 9900

TCCCCCCGGA CGGCCAGGGT GCGCTGGGCC ATATTGGACC ACATGCACGG GGCGACGCAG 9960

GGACAGGCCT CCGCCACGGC GGGGGCGCGC CACAGCGCGT TGGCGGAATC GATGTGGGCC 10020

GTCGGGGCGC AGGCGCCGCC TCCTCCCGGG GGGTCGGTAA TCCTGGATAG CAGCCATCCT 10080 AAATGGCGGG CCCGGCTGCC CGGGGGACAG AGCGACCCCA GGTCATCATC CATGGCCCAG 10140

CAGTATATGC GGCCGCCGGG GAGGTGCCAC CAGGCCCCCG GACCCAGGGC ACAGCACGCC 10200

CCCGGATTCG GGGGCGGTTC CGTGGGTACC AGGTAGGCGC CGTCGAGCTC GTGGGCCACG 10260

GGCTCGTCCG CGAGCTGTTC GGCGGCGGGG TCGGGGGTTT CCTCCGGGGG GGAGGCAGCT 10320

TCCAGGTGGC CGAAGGCTAG GGTGCACAGC AGCGGGGTCC GGGGGTGCGT TACGCTGCGG 10380 AGGTGGACGG TGGCGCAGTA GCGGCGCTCG CGGTTAAAGA AGAAAATGGC AAAGAACGTG 10440

TTCGAAGGCA GGCGCAGCGC CTTGGGCCGC GTCAGGTACA GGAAGATCTC GCAGAAAAGG 10500

GCACGCTCGG GGTCGGGGTC CGGAAGGGCC ACCTGGCACA GCGGCTCGGT GAGGACCGTG 10560

AGGCACCGAA AAATCTTAAG CCGCTCGTCC CCCCGAACGA CGCGCCACAC GAAGACAGAG 10620

TTGGCGATGC GCGCGACGAG GTCGGCTTCG GGCCCCGGGT CGGGGGCGCG CGCGTCGGGG 10680 GGGGCGCCCC GGTGACCCGG CGGGGCCGCG GCTCCCGGGG GGCCTGGCGT CGCCTGGGGA 10740

CGCCAGAGTG CCCGCTGTGC CAGGTTGGTG GTGGGGAAGG GACCGGAGAC GCACCAAAAG 10800

CAGAGGGGCC AGCGCGTGTA TGAGTTGGGG GGGGGGTGGG TGAGCGGTGG AACAAAAGCA 10860

CGCGTCAGCG GACAAGGCCG GGTCCCGTAG CCGCCCCGCG ACAGAACCGG AGTCCGACGG 10920

CACGCGCGAC GGGGTCTGCG AGGCTGAGGT ACGCCGCGGT GTTAATGGTA AACGCAAAGC 10980 CTCCCGGAAA GACCACTAGC CCGCAGAGGC GGCGATTGAA CCCAAGGCAG AGGTACGCGT 11040

AGCTCTCTCC CGGAAGGTAT TGCTCGCAGA CCCTGTGCGG GGCAGTGGAG GGGCTGCCCT 11100

CCATGAAGCG ACATTTACTC TGCTCGCGTC CATTGACGTC ACCGTCAATC ACCACTGCGA 11160

TTGGACGGTT GGTAAGGCGC AGCGTGTCTC CGCTGGTGCT GTAGTAGTCA AACGCGTAGT 11220

GGGCGTCGGA GTCGGCGAAG CGGGCGGGGA TGTCGTCGCT GAGAGGGACG AGCCGCCGCC 11280 GCCGCCCCCG ACCGCCCTGG CCGCCCAGAT GCGCCAGCAC GGCCAGGGCG TACGCGGTGT 11340

GAAAGAACGC GTCGGGGGCG GTCCCCTCGA GGGCGCGCAT CAGGTTCTCC AGGAGCACGG 11400

GGAAGCGCCG CGTCACCTCC CCTAGCCACT CGCTCTGGTG GGGGCCAAAG TCGTAGCGCA 11460

GGCGCTGGAA GATGCGCGGG CCGCCTTGGA GCGCGGCCCG GATAGAGTGG CCCAGGGCCC 11520

GCAGACACGC GATCTGGATG CGCGCGACGA AGGCCACCTC GGCCGCGATG TCAAAGGGCT 11580 GCAGCACGGG GCGCGGGTGG CGCAGGGGTC CCTCGAGCGC GGGAAAGCGA CGCAGCAGCG 11640

CCGTCTGGGC CGCGGGGGAC AGCTGGTGGG GGCGCACGAC GCGCTCGGCG GCACAGGCCT 11700

CCGTC 11706

(2) INFORMATION FOR SEQ ID NO: 156:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 63 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 156:

Met Glu Ala Pro Gly Ile Val- Trp Val Glu Glu Ser Val Ser Ala Ile 1 5 10 15 Thr Leu Tyr Ala Val Trp Leu Pro Pro Arg Thr Arg Asp Cys Leu His 20 25 30

Ala Leu Leu Tyr Leu Val Cys Arg Asp Ala Ala Gly Glu Ala Arg Ala

35 40 45

Arg Phe Ala Glu Val Ser Val Gly Ser Ser Xaa Xaa Xaa Xaa Xaa 50 55 60

(2) INFORMATION FOR SEQ ID NO: 157:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 857 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 157:

Met Ala Glu Thr Met Asn Val Ala Thr Cys Thr His Gin Thr His His 1 5 10 15

Ala Ala Arg Ala Pro Gly Ala Thr Ser Ala Pro Gly Ala Ala Ser Gly

20 25 30

Asp Pro Leu Gly Ala Arg Arg Pro Ile Gly Asp Asp Glu Cys Glu Gin 35 40 45 Tyr Thr Ser Ser Val Ser Leu Ala Arg Met Leu Tyr Gly Gly Asp Leu 50 55 60

Ala Glu Trp Val Pro Arg Val His Pro Lys Thr Thr Ile Glu Arg Gin 65 70 75 80

Gin His Gly Pro Val Thr Phe Pro Asp Ala Ser Ala Pro Thr Ala Arg 85 90 95

Cys Val Thr Val Val Arg Ala Pro Met Gly Ser Gly Lys Thr Thr Ala

100 105 110

Leu Ile Arg Trp Leu Gly Glu Ala Ile His Ser Pro Asp Thr Ser Val 115 120 125 Leu Val Val Ser Cys Arg Arg Ser Phe Thr Gin Thr Leu Ala Thr Arg 130 135 140

Phe Ala Glu Ser Gly Leu Pro Asp Phe Val Thr Tyr Phe Ser Ser Thr 145 150 155 160 Asn Tyr Ile Met Asn Asp Arg Pro Phe His Arg Leu Ile Val Gin Val

165 170 175

Glu Ser Leu His Arg Val Gly Pro Asn Leu Leu Asn Asn Tyr Asp Val 180 185 190 Leu Val Leu Asp Glu Val Met Ser Thr Leu Gly Gin Lys Pro Thr Met 195 200 205

Gin Gin Leu Gly Arg Val Asp Ala Leu Met Leu Arg Leu Leu Arg Thr

210 215 220

Cys Pro Arg Ile Ile Ala Met Asp Ala Thr Ala Asn Ala Gin Leu Val 225 230 235 240

Asp Phe Leu Cys Ser Leu Arg Gly Glu Lys Asn Val His Val Val Ile

245 250 255

Gly Glu Tyr Ala Met Pro Gly Phe Ser Ala Arg Arg Cys Leu Phe Leu 260 265 270 Pro Arg Leu Gly Pro Glu Val Leu Gin Ala Ala Leu Arg Pro Pro Gly 275 280 285

Pro Ala Gly Gly Ala Pro Pro Pro Asp Ala Pro Pro Asp Ala Thr Phe

290 295 300

Phe Gly Glu Leu Glu Ala Arg Leu Ala Gly Gly Asp Asn Val Cys lie 305 310 315 320

Phe Ser Ser Thr Val Ser Phe Ala Glu Val Val Ala Arg Phe Cys Arg

325 330 335

Gin Phe Thr Asp Arg Val Leu Leu Leu His Ser Leu Thr Pro Pro Gly 340 345 350 Asp Val Thr Thr Trp Gly Arg Tyr Arg Val Val Ile Tyr Thr Thr Val 355 360 365

Val Thr Val Gly Leu Ser Phe Asp Pro Pro His Phe Asp Ser Met Phe

370 375 380

Ala Tyr Val Lys Pro Met Asn Tyr Gly Pro Asp Met Val Ser Val Tyr 385 390 395 400

Gin Ser Leu Gly Arg Val Arg Thr Leu Arg Lys Gly Glu Leu Leu Ile

405 410 415

Tyr Met Asp Gly Ser Gly Ala Arg Ser Glu Pro Val Phe Thr Pro Met 420 425 430 Leu Leu Asn His Val Val Ser Ala Ser Gly Gin Trp Pro Ala Gin Phe 435 440 445

Ser Gin Val Thr Asn Leu Leu Cys Arg Arg Phe Lys Gly Arg Cys Asp

450 455 460

Ala Ser His Ala Asp Ala Ala Gin Arg Ser Arg Ile Tyr Ser Lys Phe 465 470 475 480

Arg Tyr Lys His Tyr Phe Glu Arg Cys Thr Leu Ala Cys Leu Ala Asp

485 490 495

Ser Leu Asn Ile Leu His Met Leu Leu Thr Leu Asn Cys Met His Val 500 505 510

Arg Phe Trp Gly His Asp Ala Ala Leu Thr Pro Arg Asn Phe Cys Leu

515 -520 525

Phe Leu Arg Gly Ile His Phe Asp Ala Leu Arg Ala Gin Arg Asp Leu 530 535 540

Arg Glu Leu Arg Cys Gin Asp Pro Asp Thr Ser Leu Ser Ala Gin Ala

545 550 555 560

Ala Glu Thr Glu Glu Val Gly Leu Phe Val Glu Lys Tyr Leu Arg Pro

565 570 575 Asp Val Ala Pro Ala Glu Val Val Met Arg Gin Ser Leu Val Gly Arg

580 585 590

Thr Arg Phe Ile Tyr Leu Val Leu Leu Glu Ala Cys Leu Arg Val Pro

595 600 605

Met Ala Ala His Ser Ser Ala Ile Phe Arg Arg Leu Tyr Asp His Tyr 610 615 620

Ala Thr Gly Val Ile Pro Thr Ile Asn Ala Ala Gly Glu Leu Glu Leu

625 630 635 640

Val His Pro Thr Leu Asn Val Ala Pro Val Trp Glu Leu Phe Arg Leu

645 650 655 Cys Ser Thr Met Ala Ala Cys Leu Gin Trp Asp Ser Met Ala Gly Gly

660 665 670

Ser Gly Arg Thr Phe Ser Pro Glu Asp Val Leu Glu Leu Leu Asn Pro

675 680 685

His Tyr Asp Arg Tyr Met Gin Leu Val Phe Glu Leu Gly His Cys Asn 690 695 700

Val Thr Asp Gly Pro Leu Leu Ser Glu Asp Ala Val Lys Arg Val Ala

705 710 715 720

Asp Ala Leu Ser Gly Cys Pro Pro Arg Gly Ser Val Ser Glu Thr Glu

725 730 735 His Ala Leu Ser Leu Phe Lys Ile Ile Trp Gly Glu Leu Phe Gly Val

740 745 750

Gin Leu Ala Lys Ser Thr Gin Thr Phe Pro Gly Ala Gly Arg Val Lys

755 760 765

Asn Leu Thr Lys Arg Ala Ile Val Glu Leu Leu Asp Ala His Arg Ile 770 775 780

Asp His Ser Ala Cys Arg Thr Gin Leu Tyr Ala Leu Leu Met Ala His 785 790 795 800

Lys Arg Glu Phe Ala Gly Ala Arg Phe Lys Leu Arg Ala Pro Ala Trp 805 810 815 Gly Arg Cys Leu Arg Thr His Ala Ser Gly Ala Gin Pro Asn Thr Asp 820 825 830

Ile Ile Ala Ala Leu Ser Glu Leu Pro Thr Glu Ala Trp Pro Met Met 835 840 845 Gin Gly Ala Val Asn Phe Ser Thr Leu 850 855

(2) INFORMATION FOR SEQ ID NO: 158:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 470 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 158:

Val Tyr Cys Ser His Ser Ser Ser Pro Met Gly Arg Arg Ala Pro Arg

1 5 10 15

Gly Ser Pro Glu Ala Ala Pro Gly Ala Asp Val Ala Pro Gly Ala Arg 20 25 30 Ala Ala Trp Trp Val Trp Cys Val Gin Val Ala Thr Phe Ile Val Ser 35 40 45

Ala Ile Cys Val Val Gly Leu Leu Val Leu Ala Ser Val Phe Arg Asp

50 55 60

Arg Phe Pro Cys Leu Tyr Ala Pro Ala Thr Ser Tyr Ala Glu Ala Asn 65 70 75 80

Ala Thr Val Glu Val Arg Gly Gly Val Ala Val Pro Leu Arg Leu Asp

85 90 95

Thr Gin Ser Leu Leu Ala Thr Tyr Ala Ile Thr Ser Thr Leu Leu Leu 100 105 110 Ala Ala Ala Val Tyr Ala Ala Val Gly Ala Val Thr Ser Arg Tyr Glu 115 120 125

Arg Ala Leu Asp Ala Ala Arg Arg Leu Ala Ala Ala Arg Met Ala Met

130 135 140

Pro His Ala Thr Leu Ile Ala Gly Asn Val Cys Ala Trp Leu Leu Gin 145 150 155 160

Ile Thr Val Leu Leu Leu Ala His Arg Ile Ser Gin Leu Ala His Leu

165 170 175

Ile Tyr Val Leu His Phe Ala Cys Leu Val Tyr Leu Ala Ala His Phe 180 185 190 Cys Thr Arg Gly Val Leu Ser Gly Thr Tyr Leu Arg Gin Val His Gly 195 200 205

Leu Ile Asp Pro Ala Pro Thr His His Arg Ile Val Gly Pro Val Arg 210 215 220 Ala Val Met Thr Asn Ala Leu Leu Leu Gly Thr Leu Leu Cys Thr Ala

225 230 235 240

Ala Ala Ala Val Ser Leu Asn -Thr Ile Ala Ala Leu Asn Phe Asn Phe

245 250 255

Ser Ala Pro Ser Met Leu Ile Cys Leu Thr Thr Leu Phe Ala Leu Leu

260 265 270

Val Val Ser Leu Leu Leu Val Val Glu Gly Val Leu Cys His Tyr Val 275 280 285

Arg Val Leu Val Gly Pro His Leu Gly Ala Ile Ala Ala Thr Gly Ile

290 295 300

Val Gly Leu Ala Cys Glu His Tyr His Thr Gly Gly Tyr Tyr Val Val

305 310 315 320

Glu Gin Gin Trp Pro Gly Ala Gin Thr Gly Val Arg Val Val Ala Ala

325 330 335

Phe Ala Met Ala Val Leu Arg Cys Thr Arg Ala Tyr Leu Tyr His Arg

340 345 350

Arg His His Thr Lys Phe Phe Val Arg Met Arg Asp Thr Arg His Arg 355 360 365

Ala His Ser Ala Leu Arg Arg Val Arg Ser Ser Met Arg Gly Ser Arg

370 375 380

Arg Gly Gly Pro Pro Gly Asp Pro Gly Tyr Ala Glu Thr Pro Tyr Ala

385 390 395 400

Ser Val Ser His His Ala Glu Ile Asp Arg Tyr Gly Asp Ser Asp Gly

405 410 415

Asp Pro Ile Tyr Asp Glu Val Ala Pro Asp His Glu Ala Glu Leu Tyr

420 425 430

Ala Arg Val Gin Arg Pro Gly Pro Val Pro Asp Ala Glu Pro Ile Tyr 435 440 445

Asp Thr Val Glu Gly Tyr Ala Pro Arg Ser Ala Gly Glu Pro Val Tyr

450 455 460

Ser Thr Val Arg Arg Trp

465 470

(2) INFORMATION FOR SEQ ID NO: 159:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 96 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 159:

Met Gly Leu Ala Phe Ser Gly-Ala Arg Pro Cys Cys Cys Arg His Asn 1 5 10 15 Val Ile Ile Thr Asp Gly Gly Glu Val Val Ser Leu Thr Ala His Glu 20 25 30

Phe Asp Val Val Asp Ile Glu Ser Glu Glu Glu Gly Asn Phe Tyr Val

35 40 45

Pro Pro Asp Met Arg Val Val Thr Arg Ala Pro Gly Pro Gin Tyr Arg 50 55 60

Arg Ala Ser Asp Pro Pro Ser Arg His Thr Arg Arg Arg Asp Pro Asp 65 70 75 80

Val Ala Arg Pro Pro Ala Thr Leu Thr Pro Pro Leu Ser Asp Ser Glu 85 90 95

(2) INFORMATION FOR SEQ ID NO: 160:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 618 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 160:

Met Ala Ala Ala Ala Thr Pro Gly Ala Lys Arg Pro Ala Asp Pro Ala

1 5 10 15

Arg Asp Pro Asp Ser Pro Pro Lys Arg Pro Arg Pro Asn Ser Leu Asp 20 25 30

Leu Ala Thr Val Phe Gly Pro Arg Pro Ala Pro Pro Arg Pro Thr Ser 35 40 45

Pro Gly Ala Pro Gly Ser His Trp Pro Gin Ser Pro Pro Arg Gly Gin 50 55 60

Pro Asp Gly Gly Ala Pro Gly Glu Lys Ala Arg Pro Asp Ala Leu Ser

65 70 75 80

Glu Ala Ser Ser Gly Pro Pro Thr Pro Asp Ile Pro Leu Ser Pro Gly 85 90 95

Gly Ala His Ala Ile Asp Pro Asp Cys Ser Pro Gly Pro Pro Asp Pro 100 105 110

Asp Pro Met Trp Ser Ala Ser Ala Ile Pro Asn Ala Leu Pro Pro His 115 120 125 lie Leu Ala Glu Thr Phe Glu Arg His Leu Arg Gly Leu Leu Arg Gly

130 135 140

Val Arg Ser Pro Leu Ala Ile -Gly Pro Leu Trp Ala Arg Leu Asp Tyr 145 150 155 160 Leu Cys Ser Leu Val Val Ser Leu Glu Ala Ala Gly Met Val Asp Arg

165 170 175

Gly Leu Gly Arg His Leu Trp Arg Leu Thr Arg Arg Ala Pro Pro Ser

180 185 190

Ala Ala Glu Ala Val Ala Pro Arg Pro Leu Met Gly Phe Tyr Glu Ala 195 200 205

Ala Thr Gin Asn Gin Ala Asp Cys Gin Leu Trp Ala Leu Leu Arg Arg

210 215 220

Gly Leu Thr Thr Ala Ser Thr Leu Arg Trp Gly Ala Gin Gly Pro Cys 225 230 235 240 Phe Ser Ser Gin Trp Leu Thr His Asn Ala Ser Leu Arg Leu Asp Ala

245 250 255

Gin Ser Ser Ala Val Met Phe Gly Arg Val Asn Glu Pro Thr Ala Arg

260 265 270

Asn Leu Leu Phe Arg Tyr Cys Val Gly Arg Ala Asp Ala Gly Val Asn 275 280 285

Asp Asp Ala Asp Ala Gly Arg Phe Val Phe His Gin Pro Gly Asp Leu

290 295 300

Ala Glu Glu Asn Val His Ala Cys Gly Val Leu Met Asp Gly His Thr 305 310 315 320 Gly Met Val Gly Ala Ser Leu Asp Ile Leu Val Cys Pro Arg Asp Pro

325 330 335

His Gly Tyr Leu Ala Pro Ala Pro Gin Thr Pro Leu Ala Phe Tyr Glu

340 345 350

Val Lys Cys Arg Ala Lys Tyr Ala Phe Asp Pro Ala Asp Pro Gly Ala 355 360 365

Pro Ala Ala Ser Ala Tyr Glu Asp Leu Met Ala Arg Arg Ser Pro Glu

370 375 380

Ala Phe Arg Ala Phe Ile Arg Ser Ile Pro Asn Pro Gly Val Arg Tyr 385 390 395 400 Phe Ala Pro Gly Arg Val Pro Gly Pro Glu Glu Ala Leu Val Thr Gin

405 410 415

Asp Arg Asp Trp Leu Asp Ser Arg Ala Ala Gly Glu Lys Arg Arg Cys

420 425 430

Ser Ala Pro Asp Arg Ala Leu Val Glu Leu Asn Ser Gly Val Val Ser 435 440 445

Glu Val Leu Leu Phe Gly Val Pro Asp Leu Glu Arg Arg Thr Ile Ser

450 455 460

Pro Val Ala Trp Ser Ser Gly Glu Leu Val Arg Arg Glu Pro Ile Phe 465 470 475 480

Ala Asn Pro Arg His Pro Asn Phe Lys Gin Ile Leu Val Gin Gly Tyr

485 - 490 495

Val Leu Asp Ser His Phe Pro Asp Cys Pro Leu Gin Pro His Leu Val 500 505 510

Thr Phe Leu Gly Arg His Arg Ala Gly Ala Glu Glu Gly Val Thr Phe

515 520 525

Arg Leu Glu Asp Gly Arg Gly Ala Pro Ala Gly Arg Gly Gly Ala Pro

530 535 540 Gly Pro Ala Lys Ala Ser Ile Leu Pro Asp Gin Ala Val Pro Ile Ala

545 550 555 560

Leu Ile Ile Thr Pro Val Arg Val Glu Pro Gly Ile Tyr Arg Asp Ile

565 570 575

Arg Arg Asn Ser Arg Leu Ala Phe Asp Asp Thr Leu Ala Lys Leu Trp 580 585 590

Ala Ser Arg Ser Pro Gly Arg Gly Pro Ala Ala Ala Asp Thr Thr Ser

595 600 605

Ser Ser Pro Thr Ala Gly Arg Ser Ser Arg 610 615

(2) INFORMATION FOR SEQ ID NO: 161:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 525 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 161:

Val Gly Gly Arg Arg Pro Gly Gly Arg Met Asp Glu Ser Gly Arg Gin 1 5 10 15 Arg Pro Ala Ser His Val Ala Ala Asp Ile Ser Pro Gin Gly Ala His 20 25 30

Arg Arg Ser Phe Lys Ala Trp Leu Ala Ser Tyr Ile His Ser Leu Ser

35 40 45

Arg Arg Ala Ser Gly Arg Pro Ser Gly Pro Ser Pro Arg Asp Gly Ala 50 55 60

Val Ser Gly Ala Arg Pro Gly Ser Arg Arg Arg Ser Ser Phe Arg Glu 65 70 75 80

Arg Leu Arg Ala Gly Leu Ser Arg Trp Arg Val Ser Arg Ser Ser Arg 85 90 95 Arg Arg Ser Ser Pro Glu Ala Pro Gly Pro Ala Ala Lys Leu Arg Arg 100 - 105 110

Pro Pro Leu Arg Arg Ser Glu Thr Ala Met Thr Ser Pro Pro Ser Pro 115 120 125

Pro Ser His Ile Leu Ser Leu Ala Arg Ile His Lys Leu Cys Ile Pro

130 135 140

Val Phe Ala Val Asn Pro Ala Leu Arg Tyr Thr Thr Leu Glu Ile Pro 145 150 155 160 Gly Ala Arg Ser Phe Gly Gly Ser Gly Gly Tyr Gly Glu Val Gin Leu

165 170 175 Ile Arg Glu His Lys Leu Ala Val Lys Thr Ile Arg Glu Lys Glu Trp 180 185 190

Phe Ala Val Glu Leu Val Ala Thr Leu Leu Val Gly Glu Cys Ala Leu 195 200 205

Arg Gly Gly Arg Thr His Asp Ile Arg Gly Phe Ile Thr Pro Leu Gly

210 215 220

Phe Ser Leu Gin Gin Arg Gin Ile Val Phe Pro Ala Tyr Asp Met Asp 225 230 235 240 Leu Gly Lys Tyr Ile Gly Gin Leu Ala Ser Leu Arg Ala Thr Thr Pro

245 250 255 Ser Val Ala Thr Ala Leu His His Cys Phe Thr Asp Leu Ala Arg Ala 260 265 270

Val Val Phe Leu Asn Thr Arg Cys Gly Ile Ser His Leu Asp Ile Lys 275 280 285

Cys Ala Asn Val Leu Val Met Leu Arg Ser Asp Ala Val Ser Leu Arg

290 295 300

Arg Ala Val Leu Ala Asp Phe Ser Leu Val Thr Leu Asn Ser Asn Ser 305 310 315 320 Thr Ile Ser Arg Gly Gin Phe Cys Leu Gin Glu Pro Asp Leu Glu Ser

325 330 335 Pro Arg Gly Phe Gly Met Pro Ala Ala Leu Thr Thr Ala Asn Phe His 340 345 350

Thr Leu Val Gly His Gly Tyr Asn Gin Pro Pro Glu Leu Leu Val Lys 355 360 365

Tyr Leu Asn Asn Glu Arg Ala Glu Phe Asn Asn Arg Pro Leu Lys His

370 375 380

Asp Val Gly Leu Ala Val Asp Leu Tyr Ala Leu Gly Gin Thr Leu Leu 385 390 395 400 Glu Leu Leu Val Ser Val Tyr Val Ala Pro Ser Leu Gly Val Pro Val

405 410 415 Thr Arg Val Pro Gly Tyr Gin Tyr Phe Asn Asn Gin Leu Ser Pro Asp 420 425 430 Phe Ala Val Leu Ala Tyr Arg Cys Val Leu His Pro Ala Leu Phe Val

435 440 445

Asn Ser Ala Glu Thr Asn Thr "His Gly Leu Ala Tyr Asp Val Pro Glu

450 455 460 Gly Ile Arg Arg His Leu Arg Asn Pro Lys Ile Arg Arg Ala Phe Thr

465 470 475 480

Glu Gin Cys Ile Asn Tyr Gin Arg Thr His Lys Ala Val Leu Ser Ser

485 490 495

Val Ser Leu Pro Pro Glu Leu Arg Pro Leu Leu Val Leu Val Ser Arg 500 505 510

Leu Cys His Ala Asn Pro Ala Ala Arg His Ser Leu Ser 515 520 525

(2) INFORMATION FOR SEQ ID NO: 162:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 217 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 162:

Met Ser Arg Asp Ala Ser His Ala Ala Leu Arg Arg Arg Leu Ala Glu

1 5 10 15

Thr His Leu Arg Ala Glu Val Tyr Arg Asp Gin Thr Leu Gin Leu His 20 25 30 Arg Glu Gly Val Ser Thr Gin Asp Pro Arg Phe Val Gly Ala Phe Met 35 40 45

Ala Ala Lys Ala Ala His Leu Glu Leu Glu Ala Arg Leu Lys Ser Arg

50 55 60

Ala Arg Leu Glu Met Met Arg Gin Arg Ala Thr Cys Val Lys Ile Arg 65 70 75 80

Val Glu Glu Gin Ala Ala Arg Arg Asp Phe Leu Thr Ala His Arg Arg

85 90 95

Tyr Leu Asp Pro Ala Leu Ser Leu Asp Ala Ala Asp Asp Arg Leu Ala 100 105 110 Asp Gin Glu Glu Gin Leu Glu Glu Ala Ala Ala Asn Ala Ser Leu Trp 115 120 125

Gly Asp Gly Asp Leu Ala Asp Gly Trp Met Ser Pro Gly Asp Ser Asp 130 135 140 Leu Leu Val Met Trp Gin Leu Thr Ser Ala Pro Lys Val His Thr Asp

145 150 155 160

Ala Pro Ser Arg Pro Gly Ser- Arg Pro Thr Tyr Thr Pro Ser Ala Ala

165 170 175 Gly Arg Pro Asp Ala Gin Ala Ala Pro Pro Pro Glu Thr Ala Pro Ser

180 185 190

Pro Glu Pro Ala Pro Gly Pro Ala Ala Asp Pro Ala Ser Gly Ser Gly

195 200 205

Phe Ala Arg Asp Cys Pro Asp Gly Glu 210 215

(2) INFORMATION FOR SEQ ID NO: 163:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 239 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 163:

Pro Ala Asp Leu Glu Pro Leu Gly Asp Pro Thr Leu Trp Arg Ala Leu 1 5 10 15

Tyr Ala Cys Val Leu Ala Ala Leu Glu Arg Gin Thr Gly Pro Val Phe

20 25 30

Val Pro Leu Arg Leu Gly Trp Asp Pro Gin Thr Gly Leu Val Val Arg 35 40 45 Val Glu Arg Ala Ser Trp Gly Pro Pro Ala Ala Pro Arg Ala Ala Leu 50 55 60

Leu Asp Val Glu Ala Lys Val Asp Val Asp Pro Leu Ala Ala Arg Val 65 70 75 80

Ala Glu His Pro Gly Ala Arg Leu Ala Trp Ala Arg Leu Ala Ala Ile 85 90 95

Arg Asp Ser Pro Gin Cys Ala Ser Ser Ala Ser Leu Ala Val Thr Ile

100 105 110

Thr Thr Arg Thr Ala Arg Phe Ala Arg Glu Tyr Thr Thr Leu Ala Phe 115 120 125 Pro Pro Thr Ser Lys Glu Gly Ala Phe Ala Asp Leu Val Glu Val Cys 130 135 140

Glu Val Gly Leu Arg Pro Arg Gly His Pro Gin Arg Val Thr Ala Arg 145 150 155 160 Val Leu Leu Pro Arg Gly Tyr Asp Tyr Phe Val Ser Ala Gly Asp Gly

165 170 175

Phe Ser Ala Pro Ala Leu Val Phe Arg Gin Trp His Thr Thr Val His 180 185 190 Ala Ala Pro Gly Ala Pro Val Phe Ala Phe Leu Gly Ala Gly Phe Asp 195 200 205

Val Arg Gly Gly Pro Val Gin Tyr Phe Ala Val Leu Gly Phe Pro Gly

210 215 220

Trp Pro Thr Phe Thr Val Pro Ala Ala Ala Xaa Xaa Xaa Xaa Xaa 225 230 235

(2) INFORMATION FOR SEQ ID NO: 164:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 315 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 164:

Val Trp Arg Val Val Arg Gly Asp Glu Arg Leu Lys Ile Phe Arg Cys 1 5 10 15

Leu Thr Val Leu Thr Glu Pro Leu Cys Gin Val Pro Asp Pro Asp Pro

20 25 30

Glu Arg Ala Leu Phe Cys Glu Ile Phe Leu Tyr Leu Trp Lys Ala Leu 35 40 45 Arg Leu Pro Ser Asn Thr Phe Phe Ala Ile Phe Phe Phe Asn Arg Glu 50 55 60

Arg Arg Tyr Cys Ala Thr Val His Leu Arg Ser Val Thr His Pro Arg 65 70 75 80

Thr Pro Leu Leu Cys Thr Leu Ala Phe Gly His Leu Glu Ala Asp Pro 85 90 95

Glu Glu Thr Pro Asp Pro Ala Ala Glu Gin Leu Ala Asp Glu Pro Val

100 105 110

Ala His Glu Leu Asp Gly Ala Tyr Leu Val Pro Thr Glu Pro Pro Pro 115 120 125 Asn Pro Gly Ala Cys Cys Ala Leu Gly Pro Gly Ala Trp Trp His Leu 130 135 140

Pro Gly Gly Arg Ile Tyr Cys Trp Ala Met Asp Asp Asp Leu Gly Ser 145 150 155 160 Leu Cys Pro Pro Gly Ser Arg Ala Arg His Leu Gly Trp Leu Leu Ser

165 170 175

Arg Ile Thr Asp Pro Pro Gly -Gly Gly Gly Ala Cys Ala Pro Thr Ala 180 185 190 His Ile Asp Ser Ala Asn Ala Leu Trp Arg Ala Pro Ala Val Ala Glu 195 200 205

Ala Cys Pro Cys Val Ala Pro Cys Met Trp Ser Asn Met Ala Gin Arg

210 215 220

Thr Leu Ala Val Arg Gly Asp Ala Ser Leu Cys Gin Leu Leu Phe Gly 225 230 235 240

His Pro Val Asp Ala Val Ile Leu Arg Gin Ala Thr Arg Arg Pro Arg

245 250 255

Ile Thr Ala His Leu His Glu Val Val Val Gly Arg Asp Gly Ala Glu 260 265 270 Ser Val Ile Arg Pro Thr Ser Ala Gly Trp Arg Leu Cys Val Leu Ser 275 280 285

Ser Tyr Thr Ser Arg Leu Phe Ala Thr Ser Cys Pro Ala Val Ala Arg

290 295 300

Ala Val Ala Arg Ala Ser Ser Ser Asp Tyr Lys 305 310 315

(2) INFORMATION FOR SEQ ID NO: 165:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 278 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 165:

Leu Thr Glu Ala Cys Ala Ala Glu Arg Val Val Arg Pro His Gin Leu 1 5 10 15

Ser Pro Ala Ala Gin Thr Ala Leu Leu Arg Arg Phe Pro Ala Leu Glu

20 25 30

Gly Pro Leu Arg His Pro Arg Pro Val Leu Gin Pro Phe Asp Ile Ala 35 40 45 Ala Glu Val Ala Phe Val Ala Arg Ile Gin Ile Ala Cys Leu Arg Ala 50 55 60

Leu Gly His Ser Ile Arg Ala Ala Leu Gin Gly Gly Pro Arg Ile Phe 65 70 75 80 Gin Arg Leu Arg Tyr Asp Phe Gly Pro His Gin Ser Glu Trp Leu Gly

85 90 95

Glu Val Thr Arg Arg Phe Pro- Val Leu Leu Glu Asn Leu Met Arg Ala 100 105 110 Leu Glu Gly Thr Ala Pro Asp Ala Phe Phe His Thr Ala Tyr Ala Val 115 120 125

Leu Ala His Leu Gly Gly Gin Gly Gly Arg Gly Arg Arg Arg Arg Leu

130 135 140

Val Pro Leu Ser Asp Asp Ile Pro Ala Arg Phe Ala Asp Ser Asp Ala 145 150 155 160

His Tyr Ala Phe Asp Tyr Tyr Ser Thr Ser Gly Asp Thr Leu Arg Leu

165 170 175

Thr Asn Arg Pro Ile Ala Val Val lie Asp Gly Asp Val Asn Gly Arg 180 185 190 Glu Gin Ser Lys Cys Arg Phe Met Glu Gly Ser Pro Ser Thr Ala Pro 195 200 205

His Arg Val Cys Glu Gin Tyr Leu Pro Gly Glu Ser Tyr Ala Tyr Leu

210 215 220

Cys Leu Gly Phe Asn Arg Arg Leu Cys Gly Leu Val Val Phe Pro Gly 225 230 235 240

Gly Phe Ala Phe Thr Ile Asn Thr Ala Ala Tyr Leu Ser Leu Ala Asp

245 250 255

Pro Val Ala Arg Ala Val Gly Leu Arg Phe Cys Arg Gly Ala Ala Thr 260 265 270 Gly Pro Gly Leu Val Arg 275

(2) INFORMATION FOR SEQ ID NO: 166:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 731 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 166:

GCGGCGGCCG GCACGGTAAA CGTGGGCCAG CCCGGAAATC CCAGCACGGC AAAGTATTGG 60 ACGGGCCCTC CCCGGACGTC AAACCCGGCC CCCAGAAAAG CGAAGACGGG GGCCAGGGCT 120

CCGGGGGCGG CGTGGACCGT GGTATGCCAC TGCCGGAAGA GGGCGACCAG CGCCGGGGCG 180

GAGAACCCGT CGCCGGCGCT CACGAAGTAG TCGTAGCCGC GCGGCAGCAG CACCCGCGCC 240

GTGACCCGCT GCGGGTGTCC GCGGGGCCGC AGGCCGACCT CGCACACCTC GACCAGGTCC 300 GCGAAGGCGC CCTCCTTGCT GGTCGGCGGA AACGCCAGGG TGGTGTATTC GCGCGCGAAA 360

CGCGCGGTCC TCGTCGTGAT GGTGACGGCG AGCGAGGCGG AGGACGCGCA CTGGGGGCTG 420

TCGCGAATGG CGGCCAGGCG CGCCCACGCC AACCGCGCGC CGGGGTGCTC GGCGACGCGC 480

GCGGCCAGGG CCAGCGGGTC GACGTCGACC TTGGCCTCCA CGTCCAGGAG GGCGGCGCGA 540 GGAGCGGCCG GCGGGCCCCA CGACGCCCTT TCGACCCTCA CGACCAGACC CGTCTGCGGG 600

TCCCAGCCCA GGCGCAGCGG GACGAAGAGG GCCACCGGCC CCGTCTGGCG CTCCAGGGCC 660

GCCAGAACGC ACGCATACAG CGCCCGCCAC AGGGTCGGGT CCCCCAGGGG CTCCAGCGGG 720

GAGGCGGCCG 731

(2) INFORMATION FOR SEQ ID NO: 167:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 239 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 167:

Pro Ala Asp Leu Glu Pro Leu Gly Asp Pro Thr Leu Trp Arg Ala Leu

1 5 10 15

Tyr Ala Cys Val Leu Ala Ala Leu Glu Arg Gin Thr Gly Pro Val Phe

20 25 30 Val Pro Leu Arg Leu Gly Trp Asp Pro Gin Thr Gly Leu Val Val Arg

35 40 45

Val Glu Arg Ala Ser Trp Gly Pro Pro Ala Ala Pro Arg Ala Ala Leu

50 55 60 Leu Asp Val Glu Ala Lys Val Asp Val Asp Pro Leu Ala Ala Arg Val 65 70 75 80

Ala Glu His Pro Gly Ala Arg Leu Ala Trp Ala Arg Leu Ala Ala Ile

85 90 95 Arg Asp Ser Pro Gin Cys Ala Ser Ser Ala Ser Leu Ala Val Thr Ile 100 105 110 Thr Thr Arg Thr Ala Arg Phe Ala Arg Glu Tyr Thr Thr Leu Ala Phe 115 120 125 Pro Pro Thr Ser Lys Glu Gly Ala Phe Ala Asp Leu Val Glu Val Cys

130 135 140 Glu Val Gly Leu Arg Pro Arg Gly His Pro Gin Arg Val Thr Ala Arg 145 150 155 160

Val Leu Leu Pro Arg Gly Tyr Asp Tyr Phe Val Ser Ala Gly Asp Gly

165 170 175

Phe Ser Ala Pro Ala Leu Val Phe Arg Gin Trp His Thr Thr Val His 180 185 190

Ala Ala Pro Gly Ala Pro Val Phe Ala Phe Leu Gly Ala Gly Phe Asp

195 , 200 205

Val Arg Gly Gly Pro Val Gin Tyr Phe Ala Val Leu Gly Phe Pro Gly

210 215 220

Trp Pro Thr Phe Thr Val Pro Ala Ala Ala Xaa Xaa Xaa Xaa Xaa 225 230 235

(2) INFORMATION FOR SEQ ID NO: 168:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3005 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 168:

GCGCTGGAGC GGGAGCAGCG CGCGGCGGAC CGGGCGGCCG GGGGAGGCGC GGGCCGCCCG 60

GCGGAGGCGG ATCTTCTCCG GGCCGACTAC GACATTATCG ACGTCAGCAA GTCCATGGAC 120

GACGACACGT ACGTGGCCAA CAGTTTCCAG CACCAGTACA TCCCCGCGTA CGGCCAGGAC 180

CTCGAGCGCC TGTCGCGCCT CTGGGAGCAC GAGCTGGTGC GCTGCTTCAA GATTCTGCGC 240

CACCGCAACA ACCAGGGCCA GGAAACGTCG ATCTCGTACT CTAGCGGGGC GATCGCCTCC 300 TTCGTGGCCC CGTATTTCGA GTACGTGCTT CGCGCCCCCC GAGCGGGCGC GCTCATCACC 360

GGCTCCGATG TCATCCTAGG GGAGGAGGAG TTATGGGAGG CGGTCTTTAA GAAAACCCGC 420

CTGCAGACGT ACCTGACAGA CGTCGCGGCC CTGTTCGTGG CGGACGTACA GCACGCGGCT 480

CTGCCCCGGC CCCCCTCCCC AACCCCCGCC GATTTCCGGG CGAGCGCGTC CCCGCGGGGC 540

GGGTCCCGGT CCCGGACCCG GACCCGATCC CGGTCGCCCG GGAGAACGCC GAGGGGTGCG 600 CCGGACCAGG GCTGGGGCGT CGAACGCAGG GATGGCCGAC CCCACGCCCG CCGATGAGGG 660

AACGGCCGCC GCCATCCTCA AACAGGCCAT CGCCGGGGAC CGCAGTCTGG TCGAGGTGGC 720

GGAGGGGATC AGCAACCAGG CGCTGCTGCG CATGGCCTGC GAGGTGCGCC AGGTCAGCGA 780

TCGCCAGCCG CGGTTTACCG CGACCAGCGT CCTGCGCGTT GACGTCACCC CCAGGGGGCG 840

GTTGCGGTTC GTTCTGGACG GGAGTTCCGA CGACGCGTAC GTGGCGTCGG AGGATTACTT 900 TAAGCGCTGC GGGGACCAGC CGACGTATCG CGGTTTTGCG GTCGTCGTCC TCACGGCCAA 960

CGAGGACCAC GTGCACAGCC TGGCCGTGCC CCCCCTCGTT CTGCTGCACC GGCTCTCCTT 1020

GTTTCGCCCC ACGGACCTCC GGGACTTCGA GCTCGTCTGC CTGCTGATGT ACCTGGAGAA 1080

CTGTCCCCGG AGCCACGCCA CGCCCTCGCT GTTCGTCAAG GTGTCGGCGT GGTTGGGGGT 1140

CGTGGCCCGC CACGCGTCTC CCTTCGAGCG CGTCCGCTGC CTTCTCCTCC GCAGCTGCCA 1200 CTGGATCCTG AACACGCTAA TGTGCATGGC GGGCGTGAAG CCCTTCGACG ACGAGCTAGT 1260

CCTGCCCCAC TGGTACATGG CCCACTACCT GCTGGCCAAC AATCCGCCCC CCGTCCTCTC 1320

GGCCCTGTTT TGCGCCACCC CGCAGAGCTC TGCGTTGCAG TTGCCCGGGC CCGTCCCCCG 1380

CACGGACTGT GTGGCCTATA ACCCGGCCGG CGTCATGGGA AGCTGCTGGA AATCCAAGGA 1440 CCTGCGTTCG GCTCTGGTGT ATTGGTGGCT TTCGGGGAGC CCCAAACGAC GGACCTCGTC 1500

GCTTTTCTAT CGGTTTTGCT AACTCCGGAA AATAAACGTG TTTTTTATGG AACGTTCCCT 1560

ACCTGTCGTG TCATCTCTCG GGGGATGGTG GTGGGCCTGT GTGTGTGTCT TGTGCACCGA 1620

AGGAGGAAAG TGGGGGGGTG GTGGTGCTGG TGGTGGAAAG ACATGATAGA GGGAACAAAG 1680 AAATAGAAGA AAACCACAAC CGGCGCGTGT CAGTAAATAC GGACGCGCGC ACACGCGGGG 1740

GTAAGTTGGA GCACGGGGCC CCAGTTTATT GACCAAATTC AGGGAAACAG AAACCGCATC 1800

TTTTCCTCGA AAGGGTACAC AAAGCTCCCG CCCTCGCCCC ACACGCCTTC CAGAACCCCC 1860

GTAAACACCA GTTGAATCTC GCGCAGGATC TCGCGCAGGT GATGGGCGCA GTCCACGGGG 1920

GGGAGCACCA AGGGCCGCGG GTACAGATCC ACGGGGACGC CGACCGACTC CCCGCCCCCG 1980 GGACATACGC GCACGACGCG TCTCCAGTAT TGCTCCGCGT CCAGCAGGGC GCCTCCGCGG 2040

AAGGCCGTTT GGGGCAGGGG GTCGTCGGCC TCGCCCGGGG GGGTCAGAAC GCTCCAGTAC 2100

TCCGCGTCCA GACGCCTCCC GAAGGCATCC AGGACAAAGC GGTCACAGGC GTCCTCCATG 2160

ATGCCCCGGG CCGCGCACAC GGCCTCCTCC GGCGGGCCGG CGGCCGGCCG CCGGAGGATT 2220

CGTCTCAGCG CGTCGCGCAT AACCTCGGCC GCCGCGGCGT ACGCGGGCCC GCGGAGAGGA 2280 AATCCCTGCA GGAAGTCGGT GTCATCGCGG GAGTTCCAGA ACCACGCCCC GGTCTGGCTC 2340

CAGGTGACGA CGTGGGTGTA GACGCCCTCT AGCGCCAGGG AGGGGGCGAG GCGCGGGCGT 2400

ATGCCGTTGG CCGAAAGTAC GGCGCGCACG GACGCCTCGA GGGCCCGGCG GGCGTCCTGG 2460

ATCGCGCCGT GCGCGGCGTC CGCGTCCCCG GGGTCCACGT TGAACAGCCC CCAGAACGCA 2520

GCCCCGGTGC CGCCGCAGAC CGCAAACTTC ACCGAGCTGG CCGTCTGCTC GATCTGCAGG 2580 CAGACGGCGG CCATGACCCC GCCGAGCAGC TGCCGGAGCG CGGGGCAGGC GTCGCACGCG 2640

TCCGGCACCA GGCGCTCCAG CACGGCCCGG GCCCAGGGCT CCGAGGGGGC GGCCGCCACC 2700

AGCGCGTCCA GCCTTTCCAG GCCCGCCCGC CCCCGGGCTT CCGGCAGCCC GGCCTCCCCG 2760

AGGCCCGCGA GGGCGGCCAG GAGCTGGGCC TGGAGCCCGG AGAAACAAAA CCGCGCCGTC 2820

CAGACCGGCC CGACGGCCGC CGGGGGGTCG AGTAGTTGGA TGGTGGTGGC CGTGGGGTGC 2880 CACCGCGCCA CCGCTTCCCG AAAGGCGGGC AGGAGGCGGC CGGCCGCCTC CGAGGCCACG 2940

GCCGGCCATG CCCGCGGGGG CAGGACGACC CTGGCGCCCA CCGCGGGCCA GGCCCCCAGG 3000

CACG 3005

(2) INFORMATION FOR SEQ ID NO: 169:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 221 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 169:

Xaa Xaa Xaa Xaa Xaa Ala Leu Glu Arg Glu Gin Arg Ala Ala Asp Arg

1 5 10 15

Ala Ala Gly Gly Gly Ala Gly Arg Pro Ala Glu Ala Asp Leu Leu Arg 20 25 30

Ala Asp Tyr Asp Ile Ile Asp Val Ser Lys Ser Met Asp Asp Asp Thr

35 -40 45

Tyr Val Ala Asn Ser Phe Gin His Gin Tyr Ile Pro Ala Tyr Gly Gin 50 55 60

Asp Leu Glu Arg Leu Ser Arg Leu Trp Glu His Glu Leu Val Arg Cys 65 70 75 80

Phe Lys Ile Leu Arg His Arg Asn Asn Gin Gly Gin Glu Thr Ser Ile 85 90 95 Ser Tyr Ser Ser Gly Ala Ile Ala Ser Phe Val Ala Pro Tyr Phe Glu 100 105 110

Tyr Val Leu Arg Ala Pro Arg Ala Gly Ala Leu Ile Thr Gly Ser Asp

115 120 125

Val Ile Leu Gly Glu Glu Glu Leu Trp Glu Ala Val Phe Lys Lys Thr 130 135 140

Arg Leu Gin Thr Tyr Leu Thr Asp Val Ala Ala Leu Phe Val Ala Asp

145 150 155 160

Val Gin His Ala Ala Leu Pro Arg Pro Pro Ser Pro Thr Pro Ala Asp

165 170 175 Phe Arg Ala Ser Asp Arg Gly Gly Ser Arg Ser Arg Thr Arg Thr Arg

180 185 190

Ser Arg Ser Pro Gly Arg Thr Pro Arg Gly Ala Pro Asp Gin Gly Trp

195 200 205

Gly Val Glu Arg Arg Asp Gly Arg Pro His Ala Arg Arg 210 215 220

(2) INFORMATION FOR SEQ ID NO: 170:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 302 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 170:

Val Arg Arg Thr Arg Ala Gly Asn Ala Gly Met Ala Asp Pro Thr Pro 1 5 10 15

Ala Asp Glu Gly Thr Ala Ala Ala Ile Leu Lys Gin Ala Ile Ala Gly

20 25 30

Asp Arg Ser Leu Val Glu Val Ala Glu Gly Ile Ser Asn Gin Ala Leu 35 40 45

Leu Arg Met Ala Cys Glu Val Arg Gin Val Ser Asp Arg Gin Pro Arg

50 55 - 60

Phe Thr Ala Thr Ser Val Leu Arg Val Asp Val Thr Pro Arg Gly Arg 65 70 75 80

Leu Arg Phe Val Leu Asp Gly Ser Ser Asp Asp Ala Tyr Val Ala Ser

85 90 95

Glu Asp Tyr Phe Lys Arg Cys Gly Asp Gin Pro Tyr Gly Phe Ala Val 100 105 110 Val Val Leu Thr Ala Asn Glu Asp His Val His Ser Leu Ala Val Pro 115 120 125

Pro Leu Val Leu Leu His Arg Leu Ser Leu Phe Arg Pro Thr Asp Leu

130 135 140

Arg Asp Phe Glu Leu Val Cys Leu Leu Met Tyr Leu Glu Asn Cys Pro 145 150 155 160

Arg Ser His Ala Thr Pro Ser Leu Phe Val Lys Val Ser Ala Trp Leu

165 170 175

Gly Val Val Ala Arg His Asp Phe Glu Arg Val Arg Cys Leu Leu Leu 180 185 190 Arg Ser Cys His Trp Ile Leu Asn Thr Leu Met Cys Met Ala Gly Val 195 200 205

Lys Pro Phe Asp Asp Glu Leu Val Leu Pro His Trp Tyr Met Ala His

210 215 220

Tyr Leu Leu Ala Asn Asn Pro Pro Pro Val Leu Ser Ala Leu Phe Cys 225 230 235 240

Ala Thr Pro Gin Ser Ser Ala Leu Gin Leu Pro Gly Pro Val Pro Arg

245 250 255

Thr Asp Cys Val Ala Tyr Asn Pro Ala Gly Val Met Gly Ser Cys Trp 260 265 270 Lys Ser Lys Asp Leu Arg Ser Ala Leu Val Tyr Trp Trp Leu Ser Gly 275 280 285

Ser Pro Lys Arg Arg Thr Ser Ser Leu Phe Tyr Arg Phe Cys 290 295 300

(2) INFORMATION FOR SEQ ID NO: 171:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 402 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 171:

Ala Cys Leu Gly Ala Trp Pro Ala Val Gly Ala Arg Val Val Leu Pro 1 5 10 15

Pro Arg Ala Trp Pro Ala Val Ala Ser Glu Ala Ala Gly Arg Leu Leu

20 25 30

Pro Ala Phe Arg Glu Ala Val Ala Arg Trp His Pro Thr Ala Thr Thr 35 40 45 Ile Gin Leu Leu Asp Pro Pro Ala Ala Val Gly Pro Val Trp Thr Ala 50 55 60

Arg Phe Cys Phe Ser Gly Leu Gin Ala Gin Leu Leu Ala Ala Gly Leu 65 70 75 80

Gly Glu Ala Gly Leu Pro Glu Arg Arg Ala Gly Leu Glu Arg Leu Asp 85 90 95

Ala Leu Val Ala Ala Ala Pro Ser Glu Pro Trp Ala Arg Ala Val Leu

100 105 110

Glu Arg Leu Val Pro Asp Ala Cys Asp Ala Cys Pro Ala Leu Arg Gin 115 120 125 Leu Leu Gly Gly Val Met Ala Ala Val Cys Leu Gin Ile Glu Gin Thr 130 135 140

Ala Ser Ser Val Lys Phe Ala Val Cys Gly Gly Thr Gly Ala Ala Phe 145 150 155 160

Trp Gly Leu Phe Asn Val Asp Pro Gly Asp Ala Asp Ala Ala His Gly 165 170 175

Ala Ile Gin Asp Ala Arg Arg Ala Leu Glu Ala Ser Val Arg Ala Val

180 185 190

Leu Ser Ala Asn Gly Ile Arg Pro Arg Leu Ala Pro Ser Leu Ala Leu 195 200 205 Glu Gly Val Tyr Thr His Val Val Thr Trp Ser Gin Thr Gly Ala Trp 210 215 220

Phe Trp Asn Ser Arg Asp Asp Thr Asp Phe Leu Gin Gly Phe Pro Leu 225 230 235 240

Arg Gly Pro Ala Tyr Ala Ala Ala Ala Glu Val Met Arg Asp Ala Leu 245 250 255

Arg Arg Ile Leu Arg Arg Pro Ala Ala Gly Pro Pro Glu Glu Ala Val

260 265 270

Cys Ala Arg Ile Met Glu Asp Ala Cys Asp Arg Phe Val Leu Asp Ala 275 280 285 Phe Gly Arg Arg Leu Asp Ala Glu Tyr Trp Ser Val Leu Thr Pro Pro 290 295 300

Gly Glu Ala Asp Asp Pro Leu Pro Gin Thr Ala Phe Arg Gly Gly Ala 305 310 315 320 Leu Leu Asp Ala Glu Gin Tyr Trp Arg Arg Val Val Arg Val Cys Pro

325 330 335

Gly Gly Gly Glu Ser Val Gly -Val Pro Val Asp Leu Tyr Pro Arg Pro

340 345 350

Leu Val Leu Pro Pro Val Asp Cys Ala His His Leu Arg Glu Ile Leu

355 360 365

Arg Glu Ile Gin Leu Val Phe Thr Gly Val Leu Glu Gly Val Trp Gly

370 375 380

Glu Gly Gly Ser Phe Val Tyr Pro Phe Glu Glu Lys Met Arg Phe Leu 385 390 395 400

Phe Pro

(2) INFORMATION FOR SEQ ID NO: 172:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 428 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 172:

CGCGACGCGG GCCGCTGGGT CCGCGGACCG GAGAACGACG TCCGCGGTCC GCGGGGCGTA 60

CCCGGACCCC ATGGCCAGCC TGTCGCCGCG ACCCCCGGCG CCCCGCCGAC ACCACCACCA 120

CCACCACCGC CGCCGCCGCC GGCGCGCCCC CCGCCGGCGC TCGACCGCCT CTGACTCATC 180

AAAATCCGGA TCCTCGTCGT CGGCGTCCTC CGCCTCCTCC TCCGCCTCCT CCTCCTCGTC 240

TGCATCCGCC TCCTCGTCTG ACGACGACGA CGACGACGCC GCCCGCGCCC CCGCCAGCGC 300 CGCAGACCAC GCCGCGGGCG GGACCCTCGG CGCGGACGAC GAGGAGGCGG GGGTGCCCGC 360

GAGGGCCCCG GGGGCGGCGC CCCGGCCGAG CCCGCCCAGG GCCGAGCCCG CCCCCGGGGC 420

CGGGGCG 428

(2) INFORMATION FOR SEQ ID NO: 173:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15900 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 173: CGCGCTCCGT GTGGACGATC GCCCCGTCGC CTGGCTGATA TAGTCCTCGG GGCGCGCGGG 60

GCGGGGGGAA AGGAGGAGGA CGCGGAGGAG GAGCGATCGA CGCCGCCGCG CCCCGGCTCG 120

CCGGGGTTCC GCCCCCAGGT GGAACCGCAT TATGCGCGGC CCCGCCCCGA CGCCCGCGCG 180 TCCGCGTCCG TGGCGGCGGC CCGTTGGTCG CGCCGCCGCC GGCTCCGCCC GCGCGGCATC 240

TCATTAGCGC CCGGCGCGGG CGGCTTCCGC TTCCGCCCGC GATGCTAATG AGACCCTCGT 300

CGCGGGCGGG CTCGCTCCCC TGCCCTTCCG GGTTCGTGGT AATGAGATGC CGGCCCCGCG 360

CTCCCGTTGG CCCCCGCCGG CCCCTTTGGG GCCGGCGAGG TCGCCCCGTT GGTCCGCGGG 420

CGGCTCCGCC CCAAAGGGGG CGGGGCCGCA GGGTAAAAGA AGTGAGAACG CGAAGCGTTC 480 GCACTTCGTC CTAATAGTAT ATATATTATT AGGGCAAAGT GCGAGCACTG GCGCCCTGCC 540

CGGGGCCCGC GTCATCCCGC GGGCTCCGCC CCAAAGGGGG CGGGGCCGCA GGGTAAAAGA 600

AGTGAGAACG CGAAGCGTTC GCACTTCGTC CTAATAGTAT ATATATTATT AGGGCAAAGT 660

GCGAGCACTG GCGCCCTGCC CGGGGCCCGC GTCATCCCGC GGGCCCCGCC CCGAGGCGGG 720

CCCGGACGGG GGGCGGGCCG TTCCTCGCGC ACATAAAGGG CCGGCGTCCC GGTCGCCGCC 780 GCACCAGGGG CACACCGGCT GCGCGGCGGA GACCGGGACG GCAGCGGCGG CATCGCGAAG 840

GGGGCCACAG CGAGACAGAG ACGCCGGCGG CGAGCGGGGC ACCGACGCAC CCGGATCGGA 900

TCGGATACAG AGACGCGGGC GCATCGGTTC CTTTTCGTTC TGCCTTTCCC TCCCCCCCCC 960

CCCCACCCTG TACGTACCGC GAGGACCCAT CCACCCACTG CAGCCTTATC GCAGGTACGG 1020

TGACCCGGGG GCGCCGGGGC GGGGGGACGG GACGGGGGGA CGGGACGGGG GGACGGGACG 1080 GGGGGACGGG ACGGGGGGAC GGGACGGGGG GACGGGACGG GGGGACGGGA CGGGGGGACG 1140

GGACGGGGGG ACGGGACGGG GGGACGGGAC GGGGGGACGG GACGGGGGGA CGGGACGGGG 1200

GGACGGGACG GGGGGACGGG ACGGGGGGAC GGGACGGGGG GACGGGACGG GGGGACGGGA 1260

CGGGGGGACG GGACGGGGGG ACGGGACGGG GGGACGGGAC GGGGGGACGG GACGGGGGGA 1320

CGGGACGGGG GGACGGGACG GGGGGACGGG ACGGGGGGAC GGGACGGGGG GACGGGACGG 1380 GGGGACGGGA CGGGGGGACG GGACGGGGGG ACGGGACGGG GGGACGGGAC GGGGGGGCCC 1440

CGATCCCAAC ATCCGCGCTT TCTCGCAGGC CGGGCGCCGC CTTCGTGGAC GGGACACCGG 1500

TGTGGTAACT GGCGACAAGG CGTCGCCACT ATGGCAGACA TCCCCCCGGA CCCGCCCGCG 1560

CTCAACACGA CGCCTGCGAA TCATGCTCCC CCATCCCCAC CCCCGGGTTC ACGGAAGCGC 1620

AGACGCCCCG TCCTCCCCAG CTCGTCGGAA TCTGAGGGTA AGCCCGACAC AGAATCGGAA 1680 TCCTCCTCGA CCGAGTCGTC CGAGGATGAG GCGGGAGACC TACGCGGCGG GCGCCGTCGC 1740

TCCCCGCGGG AGCTCGGGGG GAGGTATTTT TTGGATCTGT CGGCAGAATC GACCACGGGG 1800

ACGGAATCGG AGGGAACGGG GCCGTCGGAC GACGATGATG ATGATGCGTC AGACGGCTGG 1860

TTGGTTGACA CCCCCCCCCG TAAATCCAAG CGACCCCGAA TCAACCTGCG ATTAACGAGC 1920

TCCCCCGACC GGCGCGCGGG TGTGGTTTTC CCCGAGGTGT GGAGAAACGA CAGACCTATC 1980 CGCGCGGCGC AACCCCAGGC CCCGGCCCAG TCTTCCGGGG ATCGCGCAGC CGCACCGCGG 2040

CGCTCTGCTC GCCAGGCCCA GATGCGGAGC GGAGCCGCCT GGACGCTTGA TCTGCATTAC 2100

ATACGCCAGT GCGTCAACCA GCTCTTTCGG ATCCTGCGTG CCGCCCCGAA CCCGCCCGGC 2160

AGCGCCAACC GCCTGCGCCA CCTGGTGCGA GACTGCTACC TTATGGGCTA CTGCCGGACC 2220

CGCCTGGGGC CGCGCACGTG GGGCCGCCTG CTGCAGATCT CGGGCGGAAC CTGGGACGTG 2280 CGCCTGCGAA ACGCAATCCG GGAGGTCGAG GCGCGTTTTG AACCCGCCGC CGAGCCCGTG 2340

TGCGAGCTGC CCTGTCTGAA CGCCAGGCGT TACGGCCCCG AGTGTGATGT TGGCAATCTC 2400

GAGACCAACG GCGGCTCGAC GAGCGATGAT GAGATATCGG ATGCGACGGA CTCGGACGAT 2460

ACCCTCGCGT CCCATTCCGA CACGGAGGGG GGGCCCTCCC CGGCCGGCCG GGAGAACCCG 2520 GAATCCGCGT CCGGCGGGGC TATCGCGGCT CGGCTGGAGT GTGAGTTTGG GACGTTTGAC 2580

TGGACGTCCG AGGAGGGCTC CCAGCCCTGG CTGTCCGCGG TGGTCGCCGA TACCAGCTCC 2640

GCCGAACGCT CTGGCCTACC CGCCC-CGGGC GCGTGTCGCG CAACGGAAGC CCCAGAACGC 2700

GAGGACGGGT GCCGAAAAAT GCGCTTCCCC GCCGCCTGCC CCTATCCCTG CGGCCACACA 2760 TTTCTCCGGC CATGAGCGCG GGACCCCCAG CCCGGTGTGT TTGCCAAACG AAAATAAACG 2820

CCCTACAAGA AAGCTTTTGT GTCTGAGTGT CTGGTTTTTC TGGGGGTGGA GGAAGGAACG 2880

ACAAAAAAAG AAACAAACGC GACACCGCTC GTACGTGTAA TGGGGCGCAG TGTTTTTTAT 2940

TAGCATCGGG GGGGGGTTAG AGGTTGGTGA TTGGATAGCA AACGTGGGAT GACGGAGGCC 3000

ACTCGTCGCC AACGGCCAGC GGGGGCCCGG GGTTCTGGGG GTCATCGTCC CCCGTCTGCC 3060 AGGAGGGCTC ATCGGGAATC TCGGGTCGCC CCATGCACGT AAAACACGGG CGCTGCGTGG 3120

GGTGGGTCGC CGGATGCGGG CGGGATGATG CGGGGCGGGG TTTGTTGTGA GGAGCCACGA 3180

GGGACCGTAG CCAGCGAAGA CAGCTGCGTT CCCGGTCGCC GGGCACCACC ACGCCGTATT 3240

GGTATTCGTA TCGGCTAAGG AGATTTTCCA GGGGGTGATT AGGCGCTGCG GGGAACGGGG 3300

TCCACGACAC GGTCCGCTCG GGCAAAAACC GATCGGGCAG GGGCCACGGT TCCCCCACCC 3360 ACGCGTCGTT GGTCTTCATG GCGATGAAGC GAAACCCCAG CCGGGTTTTT TGTGCGTACT 3420

CTAAAAACGG CACACACAGG TCCGCCGCCC CGACCACCCA CAGGTGGTAT AGCCGGTGGG 3480

GGCCGGGGCG CTCTTGATGC AGGAGCCGAA AACACGCAGG GGCATCCAGA ATCTCGATGC 3540

TTTCCAGGGG GTCGTCCTCC GCAAACAGGC CCGTCGTGGT GTTTGGGGGA CAGCGACAGG 3600

AGCGGGTTCG CACGATCGGT CGGGTGAATT TGGGCAAGTC CATCAGAGGC TCGGCCAGCC 3660 TGCGAAGGTT CGCCGGGCGA ACCACCACCG GGGTTCCCAG AGGCTCGGAG GCCAGGATCC 3720

GGCATTGCCG AAGCAGAAAA CTCCACAGAG CCGGGCTTGC GTCAGCGGAA GTCCGCGGCA 3780

GGGCGTTTCG TTGGTCTAGG AGGGTAACCA CACTTACAAC AACAACGCCC ATGTCGGTAT 3840

ATTAGGCCCG TGGTCCGATC TTCACTCACT CGCCTGTCTG CGGACCTATG CACGGCGGGA 3900

CGGCGCGCGG ACCCGGGGGG GCTGCTTGCT ATCACACGGC CCGTTCGCAC GTTCGATTTT 3960 TTCAGCCTTG TTTGGTTGGC TAGGTATCCC GGATAATCTG ACGTTCCGGA TATAGGGGGC 4020

GGGGGTAGTG GGGGGGTGTG TCGACAAACT GCCGCTTCTT AAAACACCGG GGCCCGTCGC 4080

TCGGGGTGCT CGTTGGTTGG CACGCGCGAC GCGGCGAATG GCCTGTCGTA AGTTCTGTGG 4140

GGTCTACCGT AGACCCGACA AGAGACAGGA GGCGTCCGTC CCGCCGGAGA CAAACACGGC 4200

CCCGGCCTTC CCGGCGAGCA CCTTTTATAC CCCCGCGGAG GATGCGTACC TGGCCCCCGG 4260 GCCCCCGGAA ACCATCCACC CTTCCCGCCC ACCGTCCCCC GGCGAGGCTG CGCGCCTGTG 4320

TCAGCTGCAG GAGATCTTGG CCCAGATGCA CAGCGACGAG GACTACCCCA TCGTGGACGC 4380

CGCGGGTGCG GAGGAGGAAG ACGAGGCCGA CGATGACGCC CCGGATGACG TGGCCTACCC 4440

GGAGGACTAC GCGGAGGGGC GTTTTCTGTC CATGGTTTCG GCCGCCCCCC TGCCCGGAGC 4500

CAGCGGCCAT CCTCCTGTTC CGGGCCGCGC AGCCCCCCCC GACGTCCGGA CCTGCGACAG 4560 CGGTAAGGTG GGGGCCACGG GGTTCACCCC GGAAGAGCTC GACACCATGG ACCGGGAGGC 4620

ACTTCGGGCC ATCAGCCGCG GGTGCAAGCC CCCTTCGACC CTGGCAAAAC TGGTGACCGG 4680

GCTGGGATTC GCGATCCACG GAGCGCTCAT CCCGGGGTCG GAGGGGTGTG TCTTTGATAG 4740

CAGCCACCCG AACTACCCTC ATCGGGTAAT CGTCAAGGCG GGGTGGTACG CCAGCACGAA 4800

CCACGAGGCG CGGCTGCTGA GACGCCTGAA CCACCCCGCG ATCCTACCCC TCCTGGACCT 4860 GCACGTCGTT TCTGGGGTCA CGTGTCTGGT CCTCCCCAAG TATCACTGCG ACCTGTATAC 4920

CTATCTGAGC AAGCGCCCGT CTCCGTTGGG CCACCTACAG ATAACCGCGG TCTCCCGGCA 4980

GCTCTTGAGC GCCATCGACT ACGTCCACTG CGAAGGCATC ATCCACCGCG ATATTAAGAC 5040

CGAGAACATC CTCATCAACA CCCCCGAGAA CATCTGTCTG GGGGACTTTG GGGCGGCGTG 5100 CTTTGTGCGC GGGTGTCGAT CGAGCCCCTT CCATTACGGG ATCGCAGGCA CCATCGATAC 5160

AAACGCCCCC GAGGTCCTGG CCGGGGATCC GTACACCCAG GTAATCGACA TCTGGAGCGC 5220

CGGCCTGGTG ATCTTTGAGA CCGCCGTCCA CACCGCGTCC TTGTTCTCGG CCCCGCGCGA 5280

CCCCGAAAGG CGGCCGTGCG ACAACCAGAT CGCGCGCATC ATCCGACAGG CCCAGGTACA 5340 CGTCGACGAG TTTCCAACGC ACGCGGAATC GCGCCTCACC GCGCACTACC GCTCGCGGGC 5400

GGCCGGGAAC AATCGTCCGG CGTGGACCCG ACCGGCATGG ACCCGCTACT ACAAGATCCA 5460

CACAGACGTC GAATATCTCA TCTGCAAAGC CCTTACCTTT GACGCGGCGC TCCGCCCAAG 5520

CGCCGCGGAG TTGCTGCGCC TGCCGCTATT TCACCCTAAG TGACCCCGCT CCCCCCGGGG 5580

GGCGTGGAGG GGGGGCTGGT TGGATGTTTT TGCACAAAAA GACGCGGCCC TCGGGCTTTG 5640 GTGTTTTTGG CACCTTGCCG CCCGGCGTCA TGCACGCCAT CGCTCCCAGG TTGCTTCTTC 5700

TTTTTGTTCT TTCTGGTCTT CCGGGGACAC GCGGCGGGTC GGGTGTCCCC GGACCAATTA 5760

ATCCCCCCAA CAACGATGTT GTTTTCCCGG GAGGTTCCCC CGTGGCTCAA TATTGTTATG 5820

CCTATCCCCG GTTGGACGAT CCCGGGCCCT TGGGTTCCGC GGACGCCGGG CGGCAAGACC 5880

TGCCCCGGCG CGTCGTCCGT CACGAGCCCC TGGGCCGCTC GTTCCTCACG GGGGGGCTGG 5940 TTTTGCTGGC GCCGCCGGTA CGCGGATTTG GCGCACCCAA CGCAACGTAT GCGGCCCGTG 6000

TGACGTACTA CCGGCTCACC CGCGCCTGCC GTCAGCCCAT CCTCCTTCGG CAGTATGGAG 6060

GGTGTCGCGG CGGCGAGCCG CCGTCCCCAA AGACGTGCGG GTCGTACACG TACACGTACC 6120

AGGGCGGCGG GCCTCCGACC CGGTACGCTC TCGTAAATGC TTCCCTGCTG GTGCCGATCT 6180

GGGACCGCGC CGCGGAGACA TTCGAGTACC AGATCGAACT CGGCGGCGAG CTGCACGTGG 6240 GTCTGTTGTG GGTAGAGGTG GGCGGGGAGG GCCCCGCCCC CACCGCCCCC CCACAGGCGG 6300

CGCGTGCGGA GGGCGGCCCG TGCGTCCCCC CGGTCCCCGC GGGCCGCCCG TGGCGCTCGG 6360

TGCCCCCGGT ATGGTATTCC GCCCCCAACC CCGGGTTTCG TGGCCTGCGT TTCCGGGAGC 6420

GCTGTCTGCC CCCACAGACG CCCGCCGCCC CCAGCGACCT ACCACGCGTC GCTTTTGCTC 6480

CCCAGAGCCT GCTGGTGGGG ATTACGGGCC GCACGTTTAT TCGGATGGCA CGACCCACGG 6540 AAGACGTCGG GGTCCTGCCA CCCCATTGGG CCCCCGGGGC CCTAGATGAC GGTCCGTACG 6600

CCCCCTTCCC ACCCCGCCCG CGGTTTCGAC GCGCCCTGCG GACAGACCCC GAGGGGGTCG 6660

ACCCCGACGT TCGGGCCCCC CTAACCGGGC GGCGCCTCAT GGCCTTGACC GAGGACGCGT 6720

CCTCCGATTC GCCTACGTCC GCTCCGGAGA AGACGCCCCT CCCTGTGTCG GCCACCGCCA 6780

TGGCGCCCTC AGTCGACCCA AGCGCGGAAC CGACCGCCCC CGCAACCACT ACTCCCCCCG 6840 ACGAGATGGC CACACAAGCC GCAACGGTCG CCGTTACGCC GGAGGAAACG GCAGTCGCCT 6900

CCCCGCCCGC GACTGCATCC GTGGAGTCGT CGCCACTCCC CGCCGCGGCG GCAACGCCCG 6960

GGGCCGGGCA CACGAACACC AGCAGCGCCC CCGCAGCGAA AACGCCCCCC ACCACACCAG 7020

CCCCCACGAC CCCCCCGCCC ACGTCTACCC ACGCGACCCC CCGCCCCACG AGTCCGGGGC 7080

CCCAAACAAC CCCTCCCGGA CCCGCAACCC CGGGTCCGGT GGGCGCCTCC GCCGCACCCA 7140 CGGCCGATTC CCCCCTCACC GCCTCGCCCC CCGCTACCGC GCCGGGGCCC TCGGCCGCCA 7200

ACGTTTCGGT CGCCGCGACC ACCGCCACGC CCGGAACCCG GGGCACCGCC CGTACCCCCC 7260

CAACGGACCC AAAGACGCAC CCACACGGAC CCGCGGACGC TCCCCCCGGC TCGCCAGCCC 7320

CCCCACCCCC CGAACATCGC GGCGGACCCG AGGAGTTTGA GGGCGCCGGG GACGGCGAAC 7380

CCCCCGATGA CGACGACAGC GCCACCGGCC TCGCCTTCCG AACTCCGAAC CCCAACAAAC 7440 CACCCCCCGC GCGCCCCGGG CCCATCCGCC CCACGCTCCC GCCAGGAATT CTTGGGCCGC 7500

TCGCCCCCAA CACGCCTCGC CCCCCCGCCC AAGCTCCCGC TAAGGACATG CCCTCGGGCC 7560

CCACACCCCA ACACATCCCC CTGTTCTGGT TCCTAACGGC CTCCCCTGCT CTAGATATCC 7620

TCTTTATCAT CAGCACCACC ATCCACACGG CGGCGTTCGT TTGTCTGGTC GCCTTGGCAG 7680 CACAACTTTG GCGCGGCCGG GCGGGGCGCA GGCGATACGC GCACCCGAGC GTGCGTTACG 7740

TATGTCTGCC ACCCGAGCGG GATTAGGGGG TGGGGTGGGG GCGAGAAACG ATGAAGGACG 7800

GGAAAGGGAA CAGCGACCAA ATGCCACGAT AAGAACAATA AACCTGTGAC GTCAATCGGA 7860

TATGTGAGTT TGGTTGTGTT TTGTGGGACT GGGGGCGGGG GGTGGGAGGT ATCAGTGGGT 7920 GACAGAGTCT TTTAAAAGAC GTGTCCCGGG GCCCTCGAGA CGCGCAACTT TTGGCCACAC 7980

AGAGAAAGGC CCCCAGACGA AGTCACCCGG GTCCCCGAAC AAAAACAAAA ACCTTGACCG 8040

CCGCCGGGGG GCGTGCCTGT TGTTTTGGTC TCAATGGATC GGTATGCCGT TCGGACCTGG 8100

GGGATTGTGG GAATCCTCGG GTGTGCTGCT GTTGGGGCCG CACCCACCGG CCCCGCGTCC 8160

GATACAACAA ACGCGACCGC ACGCCTCCCC ACGCACCCCC CACTCATCCG TTCCGGGGGC 8220 TTTGCCGTCC CCCTCATCGT GGGGGGGCTG TGTCTCATGA TTCTGGGGAT GGCGTGTCTA 8280

CTCGAGGTCC TGCGTCGCCT GGGTCGCGAG TTGGCGAGGT GCTGCCCCCA CGCGGGCCAA 8340

TTTGCCCCAT GATTTTTCGC CTTTCTGGCC TTGCCCCCAC CCCATCGCCC CGATTGTGTG 8400

TCGGGTGCCC GGGGTACAGC AGCTATGGAG CGGTCGGTAA TATAACTTTG GTTGTCGCCA 8460

CACGCCCCGT GCCGGGCATG GGTTGTGCGG GAAAGACGAA ATAATCCGGC GATCCCCAAG 8520 CGTACCAACT TGGGGGGGGG GGGAAAGAAA CTAAAAACAC ATCAAGCCCA CAACCCATCC 8580

CACAAGGGGG GTTATGGCGG ACCCACCGCA CCACCATACT CCGATTCGAC CACATATGCA 8640

ACCAAATCAC CCCCAGAGGG GAGGTTCCAT TTTTACGAGG AGGAGGAGTA TAATAGAGTC 8700

TTTGTGTTTA AAACCCGGGG TCGGTGTGGT GTTCGGTCAT AAGCTGCATT GCGAACGACT 8760

AGTCGCCGTT TTTCGTGTGC ATCGCGTATC ACGGCATGGG GCGTTTGACC TCCGGCGTCG 8820 GGACGGCGGC CCTGCTAGTT GTCGCGGTGG GACTCCGCGT CGTCTGCGCC AAATACGCCT 8880

TAGCAGACCC CTCGCTTAAG ATGGCCGATC CCAATCGATT TCGCGGGAAG AACCTTCCGG 8940

TTTTGGACCA GCTGACCGAC CCCCCCGGGG TGAAGCGTGT TTACCACATT CAGCCGAGCC 9000

TGGAGGACCC GTTCCAGCCC CCCAGCATCC CGATCACTGT GTACTACGCA GTGCTGGAAC 9060

GTGCCTGCCG CAGCGTGCTC CTACATGCCC CATCGGAGGC CCCCCAGATC GTGCGCGGGG 9120 CTTCGGACGA GGCCCGAAAG CACACGTACA ACCTGACCAT CGCCTGGTAT CGCATGGGAG 9180

ACAATTGCGC TATCCCCATC ACGGTTATGG AATACACCGA GTGCCCCTAC AACAAGTCGT 9240

TGGGGGTCTG CCCCATCCGA ACGCAGCCCC GCTGGAGCTA CTATGACAGC TTTAGCGCCG 9300

TCAGCGAGGA TAACCTGGGA TTCCTGATGC ACGCCCCCGC CTTCGAGACC GCGGGTACGT 9360

ACCTGCGGCT AGTGAAGATA AACGACTGGA CGGAGATCAC ACAATTTATC CTGGAGCACC 9420 GGGCCCGCGC CTCCTGCAAG TACGCTCTCC CCCTGCGCAT CCCCCCGGCA GCGTGCCTCA 9480

CCTCGAAGGC CTACCAACAG GGCGTGACGG TCGACAGCAT CGGGATGCTC CCCCGCTTTA 9540

TCCCCGAAAA CCAGCGCACC GTCGCCCTAT ACAGCTTAAA AATCGCCGGG TGGCACGGCC 9600

CCAAGCCCCC GTACACCAGC ACCCTGCTGC CGCCGGAGCT GTCCGACACC ACCAACGCCA 9660

CGCAACCCGA ACTCGTTCCG GAAGACCCCG AGGACTCGGC CCTCTTAGAG GATCCCGCCG 9720 GGACGGTGTC TTCGCAGATC CCCCCAAACT GGCACATCCC GTCGATCCAG GACGTCGCGC 9780

CGCACCACGC CCCCGCCGCC CCCAGCAACC CGGGCCTGAT CATCGGCGCG CTGGCCGGCA 9840

GTACCCTGGC GGTGCTGGTC ATCGGCGGTA TTGCGTTTTG GGTACGCCGC CGCGCTCAGA 9900

TGGCCCCCAA GCGCCTACGT CTCCCCCACA TCCGGGATGA CGACGCGCCC CCCTCGCACC 9960

AGCCATTGTT TTACTAGAGG AGTATCCCCG CTCCCGTGTA CCTCTGGGCC CGTGTGGGAG 10020 GGTGGCTGGG GTATTTGGGT GGGACTTGGA CTCCGCATAA AGGGAGTCTC GAAGGAGGGA 10080

AACTAGGACA GTTCATAGGC CGGGAGCGTG GGGCGCGCAC CGCTGTCCCG ACGATTAGCC 10140

ACCGCGCCCA CAGTCACCTC GACCCGTCCG ATCCCGGTAT GCCCGGCCGC TCGCTGCAGG 10200

GCCTGGCGAT CCTGGGCCTG TGGGTCTGCG CCACCGGCCT GGTCGTCCGC GGCCCCACGG 10260 TCAGTCTGGT CTCAGACTCA CTCGTGGATG CCGGGGCCGT GGGGCCCCAG GGCTTCGTGG 10320

AAGAGGACCT GCGTGTTTTC GGGGAGCTTC ATTTTGTGGG GGCCCAGGTC CCCCACACAA 10380

ACTACTACGA CGGCATCATC GAGCTGTTTC ACTACCCCCT GGGGAACCAC TGCCCCCGCG 10440

TTGTACACGT GGTCACACTG ACCGCATGCC CCCGCCGCCC CGCCGTGGCG TTCACCTTGT 10500 GTCGCTCGAC GCACCACGCC CACAGCCCCG CCTATCCGAC CCTGGAGCTG GGTCTGGCGC 10560

GGCAGCCGCT TCTGCGGGTT CGAACGGCAA CGCGCGACTA TGCCGGTCTG TATGTCCTGC 10620

GCGTATGGGT CGGCAGCGCG ACGAACGCCA GCCTGTTTGT TTTGGGGGTG GCGCTCTCTG 10680

CCAACGGGAC GTTTGTGTAT AACGGCTCGG ACTACGGCTC CTGCGATCCG GCGCAGCTTC 10740

CCTTTTCGGC CCCGCGCCTG GGACCCTCGA GCGTATACAC CCCCGGAGCC TCCCGGCCCA 10800 CCCCTCCACG GACAACGACA TCCCCGTCCT CCCCCCGAGA CCCGACCCCC GCCCCCGGGG 10860

ACACAGGGAC GCCCGCGCCC GCGAGCGGCG AGAGAGCCCC GCCCAATTCC ACGCGATCGG 10920

CCAGCGAATC GAGACACAGG CTAACCGTAG CCCAGGTAAT CCAGATCGCC ATACCGGCGT 10980

CCATCATCGC CTTTGTGTTT CTGGGCAGCT GTATCTGCTT CATCCATAGA TGCCAGCGCC 11040

GATACAGGCG CCCCCGCGGC CAGATTTACA ACCCCGGGGG CGTTTCCTGC GCGGTCAACG 11100 AGGCGGCCAT GGCCCGCCTC GGAGCCGAGC TGCGATCCCA CCCAAACACC CCCCCCAAAC 11160

CCCGACGCCG TTCGTCGTCG TCCACGACCA TGCCTTCCCT AACGTCGATA GCTGAGGAAT 11220

CGGAGCCAGG TCCAGTCGTG CTGCTGTCCG TCAGTCCTCG GCCCCGCAGT GGCCCGACGG 11280

CCCCCCAAGA GGTCTAGGTC CAAGCGGGCC GTTCGGCAGG CCCGCCCCAC CGCCCCCATC 11340

GTGGTTATTT CCCCCCCAAT AAACCGATGT TATTTGCCTA TATGCGTGTG TTGGATCCCT 11400 TTGTGATCGT TCGTCATTCC CCGGATGGCA TGGGAGGCGG GTAATGGATG GGCGGGGCCC 11460

GGGGGGGGAG GAAAAAGAAT AAAGGGGGTA GTGTCGGAGA GGCCCGCCGC GCATTTAAGG 11520

AGTCGCCGCC CCGACTCTGT GTCTTCGGGT GACTTGGTGC GCCGCCGTCA GCTAGTCTCC 11580

GATCTGCCCC GACCGACGGC TCCTGCCACC CGAACATGGC TCGCGGGGCC GGGTTGGTGT 11640

TTTTTGTTGG AGTTTGGGTC GTATCGTGCC TGGCGGCAGC ACCCAGAACG TCCTGGAAAC 11700 GGGTAACCTC GGGCGAGGAC GTGGTGTTGC TTCCGGCGCC CGCGGGGCCG GAGGAACGCA 11760

CCCGGGCCCA CAAACTACTG TGGGCCGCGG AACCCCTGGA TGCCTGCGGT CCCCTGCGCC 11820

CGTCGTGGGT GGCGCTGTGG CCCCCCCGAC GGGTGCTCGA GACGGTCGTG GATGCGGCGT 11880

GCATGCGCGC CCCGGAACCG CTCGCCATAG CATACAGTCC CCCGTTCCCC GCGGGCGACG 11940

AGGGACTGTA TTCGGAGTTG GCGTGGCGCG ATCGCGTAGC CGTGGTCAAC GAGAGTCTGG 12000 TCATCTACGG GGCCCTGGAG ACGGACAGCG GTCTGTACAC CCTGTCCGTG GTCGGCCTAA 12060

GCGACGAGGC GCGCCAAGTG GCGTCGGTGG TTCTGGTCGT GGAGCCCGCC CCTGTGCCGA 12120

CCCCGACCCC CGACGACTAC GACGAAGAAG ACGACGCGGG CGTGAGCGAA CGCACGCCGG 12180

TCAGCGTTCC CCCCCCAACC CCCCCCCGTC GTCCCCCCGT CGCCCCCCCG ACGCACCCTC 12240

GTGTTATCCC CGAGGTGTCC CACGTGCGCG GGGTAACGGT CCATATGGAG ACCCCGGAGG 12300 CCATTCTGTT TGCCCCCGGG GAGACGTTTG GGACGAACGT CTCCATCCAC GCCATTGCCC 12360

ACGACGACGG TCCGTACGCC ATGGACGTCG TCTGGATGCG GTTTGACGTG CCGTCCTCGT 12420

GCGCCGAGAT GCGGATCTAC GAAGCTTGTC TGTATCACCC GCAGCTTCCA GAGTGTCTAT 12480

CTCCGGCCGA CGCGCCGTGC GCCGTAAGTT CCTGGGCGTA CCGCCTGGCG GTCCGCAGCT 12540

ACGCCGGCTG TTCCAGGACT ACGCCCCCGC CGCGATGTTT TGCCGAGGCT CGCATGGAAC 12600 CGGTCCCGGG GTTGGCGTGG CTGGCCTCCA CCGTCAATCT GGAATTCCAG CACGCCTCCC 12660

CCCAGCACGC CGGCCTCTAC CTGTGCGTGG TGTACGTGGA CGATCATATC CACGCCTGGG 12720

GCCACATGAC CATCAGCACC GCGGCGCAGT ACCGGAACGC GGTGGTGGAA CAGCACCTCC 12780

CCCAGCGCCA GCCCGAGCCC GTCGAGCCCA CCCGCCCGCA CGTGAGAGCC CCCCCTCCCG 12840 CGCCCTCCGC GCGCGGCCCG CTGCGCCTCG GGGCGGTGCT GGGGGCGGCC CTGTTGCTGG 12900

CCGCCCTCGG GCTGTCCGCG TGGGGCGTGC ATGACCTGCT GGCGCAGGCG CTCCTGGCGG 12960

GCGGTTAAAA GCCGGGCCTC GGCGACGGGC CCCACTTACA TTCGCGTGGC GGACAGCGAG 13020

CTGTACGCGG ACTGGAGTTC GGACAGCGAG GGGGAGCGCG ACGGGTCCCT GTGGCAGGAC 13080 CCTCCGGAGA GACCCGACTC TCCCTCCACA AATGGATCCG GCTTTGAGAT CTTATCACCA 13140

ACGGCTCCGT CTGTATACCC CCATAGCGAG GGGCGTAAAT CTCGCCGCCC GCTCACCACC 13200

TTTGGTTCGG GAAGCCCGGG CCGTCGTCAC TCCCAGGCCT CCTATTCGTC CGTCCTCTGG 13260

TAAGGCGTCT TCCGACGACG CGGACGTCGG CGATGAACTG ATTGCCATCG CGGACGCACG 13320

CGGGGACCCG CCAGAGACCC TGCCCCCCGG CGCGGGCGGC GCCGCGCCCG CGTGCCGCAG 13380 ACCACCTCGC GGCGGCTCCC CCGCGGCCTT TCCCGTGGCC CTCCACGCCG TGGACGCCCC 13440

CTCCCAATTC GTCACCTGGC TCGCCGTGCG CTGGCTGCGG GGGGCGGTGG GTCTCGGGGC 13500

CGTCCTGTGC GGGATTGCGT TTTACGTGAC GTCAATCGCC CGAGGCGCAT AAAGGTCCGG 13560

CGGCCAGCCC CGCCGCAGCT CATAAAAATC GTGAGTCACG GCAACCGCAC CTTCGCCTCC 13620

GGCCCTCCGC CAGCGCCCTT CCGCGTCCGC GATGACCTCC CGGCCCGCCG ACCAAGACTC 13680 GGTGCGTTCC AGCGCGTCGG TGCCGCTTTA CCCCGCGGCC TCGCCCGTCC CGGCAGAAGC 13740

CTACTACTCG GAAAGCGAAG ACGAGGCCGC CAACGACTTC CTCGTGCGCA TGGGCCGCCA 13800

GCAGTCGGTC CTAAGGCGCC GACGGCGGCG CACGCGGTGC GTCGGGCTGG TTATCGCCTG 13860

TCTCGTCGTG GCCCTCCTAT CTGGAGGGTT CGGGGCACTT TTGGTGTGGC TGCTCCGCTA 13920

AATGACGCCT CGATGTATGG CGCCTTCTTC GCCCCCACCC CTCGCCGCGA CCCACGTCCG 13980 TATGTTAATT GCAATAAAGT GGTTGATTGT CATTACGGTC TACTAGGTTG TCTTTTTTTT 14040

TTGGGGGGGG GGGGAAGGAA ATGCAGAAAA GGGTAAGAAA TTCTCGGAAT TTCACCCCCC 14100

GGGGGGGGCA AGTGCAGTAC CCCAGTTCCT CAGTGTTTGG GAAATCTATT GAACTCTCCC 14160

GGCTCCTCCG TGTTAGGGAA GTCTCTTGGG GAAATCTATT GACCTCTCGC CCCCCCCCCC 14220

AGGAGGGGGC AGTGCAGTAC CCCAGTTCCT CCGTGCTGGG GAAATCTCTC TGCCGGGTAC 14280 GGGCTCCAGA CGAAGGACCC ATACATTTCC CCATCCGCAC CCCACATCTG GCGTTCTAGA 14340

GTCACGACGC ATTTGCCCCC GTCCCCGCAG CAACACACAA AGCGATTTCA ATTTTCACGA 14400

TTTTATTATT AATTACACCA ACCACCCTGT CCCCGGGACG TGGTCAGGAC CGGGGGTCCG 14460

CACCCAAACG CACGAAACAA ATGCTGGCAG TGTGCCGAAT ATAACCCCGC GTAGGAACAC 14520

GTCGACGCGT GCGCCAAACA GCACCAGAAG GCGCATGCCA TCAGCAGGTC GTGCATATGG 14580 CGATGTGTTT GGACGCAGGG CGCAGCCGCG GCGATAAAAT TCATGGCGGC CGTCCGCCAG 14640

GGCCACAGCG GCGAGGACTC CCTGTTGGCC CGAAGCCATT GGGTATGAAC CAGCTGCGCC 14700

TCCTGTCCGA CCCTGGCTCC CGCCAGCGGG GGCGGTGGGT CGTGGGTGTT GAGAGCACAC 14760

AGGCGGGACA CCTCGATCAC CGTCCGAAAA AAGGCCCGGT GGTCCGCGGG CAGCATCTGC 14820

AGGTGCGCCA GGGCCTGGGC GTTGAGAGGG TACAACTCGG AGCCGGGGGA CTCCGGGGGC 14880 CGGTCCGCGC GGTGCCGCGA GTGGGCACGC TTTGGGGCCC GGGTGTCGGA CGCGGGCGCG 14940

TTACGGATCC CGACGCGGGG CAGAACGTAC GTGCGTTGGC GCGGCGATGA GGGGTCCGGG 15000

CTGCCGAGGG GGGCGTAGGG GACCGGGCTA GGCAAGCCCG CGGGTTGCGC GGGGTTCCCG 15060

TGGGGGTCTA GGCTCCCTGG GCACCCGTGG GGGTCGTGGG GGTCGCGGGT CCCTGGGTAT 15120

GCGCGGGACC CTGGGTTCTC TGGGAGATCG TGGAACTCGC GGTTCCCTGG GCTCTCGGGG 15180 AACCCGGGGC TCCCTGGGGA CACGTGGTGC CCTGGGAATT CTTGATGGTC GGACGGCTTC 15240

AGATGGCTTC GGGATCGAGA GGGCCGCACA GACTCGTAGT AGACCCGAAT CTCCACGTTT 15300

CCCCGCCGCC GGATCATGGT CGCCGCCCCG GTGCGGGGGC CCGTCGGTCG GAAGCGAGTG 15360

CCCTTCAAGC GTGTCCGCTC CTCTGGGCTG CATGCCGTCG GATGGGGTGC CTTTTAAGGA 15420 AAGGTCTCGG CTGCCCGCCC CAACCGGGGT TTGGGGGTGG GCCGGGGAAA CCCCGGATGC 15480

CATGGGGGGG GTCACACCCT AAGCGCCGGC GCGCTGGTTG GGTGGGGGTA GAGGGGAGTC 15540

CCCGGTCGAC GAGATCGTAT CAAGGGGCCA GCACGCGATC CTGCCGCTCG TTCGATCTAG 15600

CACACCCACG GGTCTGCTGT GTGGGATTTC GACTCGCGGG ATCCGATCGC ACGTCCGGAG 15660 GACACAGCAG CGGGAGCTCC GGGTCGGTCA CCGCAGTTCT GGCCGCCTCT CGGTCCTCCC 15720

GTTCCCTTTT ATGGATCTCC GCGCAGACAT CGCCATACGT CCGGTGTGTG CACCGCGAAG 15780

AATCCAAAAA CATGTCCGTC GTTTTCAGGG CCCAAGACAT GGTGTCCCGT CCACGAAGGC 15840

GGCGCCCGGC CTGCGAGAAA GCGCGGATGT TGGGATCGGG GCCCCCCCGT CCCGTCCCC 15900

(2) INFORMATION FOR SEQ ID NO: 174:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 414 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 174:

Met Ala Asp Ile Pro Pro Asp Pro Pro Ala Leu Asn Thr Thr Pro Ala

1 5 10 15

Asn His Ala Pro Pro Ser Pro Pro Pro Gly Ser Arg Lys Arg Arg Arg 20 25 30

Pro Val Leu Pro Ser Ser Ser Glu Ser Glu Gly Lys Pro Asp Thr Glu

35 40 45

Ser Glu Ser Ser Ser Thr Glu Ser Ser Glu Asp Glu Ala Gly Asp Leu 50 55 60 Arg Gly Gly Arg Arg Arg Ser Pro Arg Glu Leu Gly Gly Arg Tyr Phe 65 70 75 80

Leu Asp Leu Ser Ala Glu Ser Thr Thr Gly Thr Glu Ser Glu Gly Thr

85 90 95

Gly Pro Ser Asp Asp Asp Asp Asp Asp Ala Ser Asp Gly Trp Leu Val 100 105 110

Asp Thr Pro Pro Arg Lys Ser Lys Arg Pro Arg Ile Asn Leu Arg Leu

115 120 125

Thr Ser Ser Pro Asp Arg Arg Ala Gly Val Val Phe Pro Glu Val Trp 130 135 140 Arg Asn Asp Arg Pro Ile Arg Ala Ala Gin Pro Gin Ala Pro Ala Gin 145 150 155 160

Ser Ser Gly Asp Arg Ala Ala Ala Pro Arg Arg Ser Ala Arg Gin Ala 165 170 175 Gin Met Arg Ser Gly Ala Ala Trp Thr Leu Asp Leu His Tyr Ile Arg

180 185 190

Gin Cys Val Asn Gin Leu Phe- Arg Ile Leu Arg Ala Ala Pro Asn Pro 195 200 205 Pro Gly Ser Ala Asn Arg Leu Arg His Leu Val Arg Asp Cys Tyr Leu 210 215 220

Met Gly Tyr Cys Arg Thr Arg Leu Gly Pro Arg Thr Trp Gly Arg Leu 225 230 235 240

Leu Gin Ile Ser Gly Gly Thr Trp Asp Val Arg Leu Arg Asn Ala Ile 245 250 255

Arg Glu Val Glu Ala Arg Phe Glu Pro Ala Ala Glu Pro Val Cys Glu

260 265 270

Leu Pro Cys Leu Asn Ala Arg Arg Tyr Gly Pro Glu Cys Asp Val Gly 275 280 285 Asn Leu Glu Thr Asn Gly Gly Ser Thr Ser Asp Asp Glu Ile Ser Asp 290 295 300

Ala Thr Asp Ser Asp Asp Thr Leu Ala Ser His Ser Asp Thr Glu Gly 305 310 315 320

Gly Pro Ser Pro Ala Gly Arg Glu Asn Pro Glu Ser Ala Ser Gly Gly 325 330 335

Ala Ile Ala Ala Arg Leu Glu Cys Glu Phe Gly Thr Phe Asp Trp Thr

340 345 350

Ser Glu Glu Gly Ser Gin Pro Trp Leu Ser Ala Val Val Ala Asp Thr 355 360 365 Ser Ser Ala Glu Arg Ser Gly Leu Pro Ala Pro Gly Ala Cys Arg Ala 370 375 380

Thr Glu Ala Pro Glu Arg Glu Asp Gly Cys Arg Lys Met Arg Phe Pro 385 390 395 400

Ala Ala Cys Pro Tyr Pro Cys Gly His Thr Phe Leu Arg Pro 405 410

(2) INFORMATION FOR SEQ ID NO: 175:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 287 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 175: Met Gly Val Val Val Val Ser Val Val Thr Leu Leu Asp Gin Arg Asn

1 5 10 15

Ala Leu Pro Arg Thr Ser Ala Asp Asp Ala Leu Trp Ser Phe Leu Leu 20 25 30 Arg Gin Cys Arg Ile Leu Ala Ser Glu Pro Leu Gly Thr Pro Val Val 35 40 45

Val Arg Pro Ala Asn Leu Arg Arg Leu Ala Glu Pro Leu Met Asp Leu

50 55 60

Pro Lys Phe Trp Ile Val Arg Thr Arg Ser Cys Arg Cys Pro Pro Asn 65 70 75 80

Thr Thr Thr Gly Leu Phe Ala Glu Asp Asp Pro Leu Glu Ser Ile Glu

85 90 95

Ile Leu Asp Ala Pro Ala Cys Phe Arg Leu Leu His Gin Glu Arg Pro 100 105 110 Gly Pro His Arg Leu Tyr His Leu Trp Val Val Gly Ala Ala Asp Leu 115 120 125

Cys Val Pro Phe Leu Glu Tyr Ala Gin Lys Thr Arg Leu Gly Phe Arg

130 135 140

Phe Ile Ala Met Lys Thr Asn Asp Ala Trp Val Gly Glu Pro Trp Pro 145 150 155 160

Leu Pro Asp Arg Phe Leu Pro Glu Arg Thr Val Ser Trp Thr Pro Phe

165 170 175

Pro Ala Ala Pro Asn His Pro Leu Glu Asn Leu Leu Ser Arg Tyr Glu 180 185 190 Tyr Gin Tyr Gly Val Val Val Pro Gly Asp Arg Glu Arg Ser Cys Leu 195 200 205

Arg Trp Leu Arg Ser Leu Val Ala Pro His Asn Lys Pro Arg Pro Ala

210 215 220

Ser Ser Arg Pro His Pro Ala Thr His Pro Thr Gin Arg Pro Cys Phe 225 230 235 240

Thr Cys Met Gly Arg Pro Glu Ile Pro Asp Glu Pro Ser Trp Gin Thr

245 250 255

Gly Asp Asp Asp Pro Gin Asn Pro Gly Pro Pro Leu Ala Val Gly Asp 260 265 270 Glu Trp Pro Pro Ser Ser His Val Cys Tyr Pro Ile Thr Asn Leu 275 280 285

(2) INFORMATION FOR SEQ ID NO: 176:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 507 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 176:

Val Gly Gly Cys Val Asp Lys Leu Pro Leu Leu Lys Thr Pro Gly Pro

1 5 10 15

Val Arg Ala Arg Trp Leu Ala Arg Ala Thr Arg Arg Met Ala Cys Arg 20 25 30

Lys Phe Cys Gly Val Tyr Arg Arg Pro Asp Lys Arg Gin Glu Ala Ser

35 40 45

Val Pro Pro Glu Thr Asn Thr Ala Pro Ala Phe Pro Ala Ser Thr Phe 50 55 60 Tyr Thr Pro Ala Glu Asp Ala Tyr Leu Ala Pro Gly Pro Pro Glu Thr 65 70 75 80

Ile His Pro Ser Arg Pro Pro Ser Pro Gly Glu Ala Ala Arg Leu Cys

85 90 95

Gin Leu Gin Glu Ile Leu Ala Gin Met His Ser Asp Glu Asp Tyr Pro 100 105 110

Ile Val Asp Ala Ala Gly Ala Glu Glu Glu Asp Glu Ala Asp Asp Asp

115 120 125

Ala Pro Asp Asp Val Ala Tyr Pro Glu Asp Tyr Ala Glu Gly Arg Phe

130 135 140 Leu Ser Met Val Ser Ala Ala Pro Leu Pro Gly Ala Ser Gly His Pro

145 150 155 160

Pro Val Pro Gly Arg Ala Ala Pro Pro Asp Val Arg Thr Cys Asp Ser

165 170 175

Gly Lys Val Gly Ala Thr Gly Phe Thr Pro Glu Glu Leu Asp Thr Met 180 185 190

Asp Arg Glu Ala Leu Arg Ala Ile Ser Arg Gly Cys Lys Pro Pro Ser

195 200 205

Thr Leu Ala Lys Leu Val Thr Gly Leu Gly Phe Ala Ile His Gly Ala

210 215 220 Leu Ile Pro Gly Ser Glu Gly Cys Val Phe Asp Ser Ser His Pro Asn

225 230 235 240

Tyr Pro His Arg Val Ile Val Lys Ala Gly Trp Tyr Ala Ser Thr Asn

245 250 255

His Glu Ala Arg Leu Leu Arg Arg Leu Asn His Pro Ala Ile Leu Pro 260 265 270

Leu Leu Asp Leu His Val Val Ser Gly Val Thr Cys Leu Val Leu Pro

275 280 285

Lys Tyr His Cys Asp Leu Tyr Thr Tyr Leu Ser Lys Arg Pro Ser Pro 290 295 300

Leu Gly His Leu Gin Ile Thr Ala Val Ser Arg Gin Leu Leu Ser Ala 305 310 - 315 320

Ile Asp Tyr Val His Cys Glu Gly Ile Ile His Arg Asp Ile Lys Thr 325 330 335

Glu Asn Ile Leu Ile Asn Thr Pro Glu Asn Ile Cys Leu Gly Asp Phe

340 345 350

Gly Ala Ala Cys Phe Val Arg Gly Cys Arg Ser Ser Pro Phe His Tyr 355 360 365 Gly Ile Ala Gly Thr Ile Asp Thr Asn Ala Pro Glu Val Leu Ala Gly 370 375 380

Asp Pro Tyr Thr Gin Val Ile Asp Ile Trp Ser Ala Gly Leu Val Ile 385 390 395 400

Phe Glu Thr Ala Val His Thr Ala Ser Leu Phe Ser Ala Pro Arg Asp 405 410 415

Pro Glu Arg Arg Pro Cys Asp Asn Gin Ile Ala Arg Ile Ile Arg Gin

420 425 430

Ala Gin Val His Val Asp Glu Phe Pro Thr His Ala Glu Ser Arg Leu 435 440 445 Thr Ala His Tyr Arg Ser Arg Ala Ala Gly Asn Asn Arg Pro Ala Trp 450 455 460

Trp Ala Trp Thr Arg Tyr Tyr Lys Ile His Thr Asp Val Glu Tyr Leu 465 470 475 480

Ile Cys Lys Ala Leu Thr Phe Asp Ala Ala Leu Arg Pro Ser Ala Ala 485 490 495

Glu Leu Leu Arg Leu Pro Leu Phe His Pro Lys 500 505

(2) INFORMATION FOR SEQ ID NO: 177:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 392 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 177:

Val Cys Ile Ala Tyr His Gly Met Gly Arg Leu Thr Ser Gly Val Gly

1 5 10 15

Thr Ala Ala Leu Leu Val Val Ala Val Gly Leu Arg Val Val Cys Ala 20 25 30

Lys Tyr Ala Asp Pro Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg

35 - 40 45

Gly Lys Asn Leu Pro Val Leu Asp Gin Leu Thr Asp Pro Pro Gly Val 50 55 60

Lys Arg Val Tyr His Ile Gin Pro Ser Leu Glu Asp Pro Phe Gin Pro

65 70 75 80

Pro Ser Ile Pro Ile Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys

85 90 95 Arg Ser Val Leu Leu His Ala Pro Ser Glu Ala Pro Gin Ile Val Arg

100 105 110

Gly Ala Ser Asp Glu Ala Arg Lys His Thr Tyr Asn Leu Thr Ile Ala

115 120 125

Trp Tyr Arg Met Gly Asp Asn Cys Ala Ile Pro Ile Thr Val Met Glu 130 135 140

Tyr Thr Glu Cys Pro Tyr Asn Lys Ser Leu Gly Val Cys Pro Ile Arg

145 150 155 160

Thr Gin Pro Arg Trp Ser Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu

165 170 175 Asp Asn Leu Gly Phe Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly

180 185 190

Thr Tyr Leu Arg Leu Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gin

195 200 205

Phe Ile His Arg Ala Arg Ala Ser Cys Lys Tyr Ala Leu Pro Leu Arg 210 215 220

Ile Pro Pro Ala Ala Cys Leu Thr Ser Lys Ala Tyr Gin Gin Gly Val

225 230 235 240

Thr Val Asp Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gin

245 250 255 Arg Thr Val Ala Lys Leu Lys Ile Ala Gly Trp His Gly Pro Lys Pro

260 265 270

Pro Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Asp Thr Thr Asn

275 280 285

Ala Thr Gin Pro Glu Leu Val Pro Glu Asp Pro Glu Asp Ser Ala Leu 290 295 300

Leu Glu Asp Pro Ala Gly Thr Val Ser Ser Gin Ile Pro Pro Asn Trp 305 310 315 320

His Ile Pro Ser Ile Gin Asp Val Ala Pro His His Ala Pro Ala Ala 325 330 335 Pro Ser Asn Pro Gly Leu Ile Ile Gly Ala Gly Ser Thr Leu Ala Val 340 345 350

Leu Val Ile Gly Gly Ile Ala Phe Trp Val Arg Arg Arg Ala Gin Met 355 360 365 Ala Pro Lys Arg Leu Arg Leu Pro His Ile Arg Asp Asp Asp Ala Pro

370 375 380

Pro Ser His Gin Pro Leu Phe- Tyr 385 390

(2) INFORMATION FOR SEQ ID NO: 178:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 392 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 178:

Val Cys Ile Ala Tyr His Gly Met Gly Arg Leu Thr Ser Gly Val Gly 1 5 10 15 Thr Ala Ala Leu Leu Val Val Ala Val Gly Leu Arg Val Val Cys Ala 20 25 30

Lys Tyr Ala Asp Pro Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg

35 40 45

Gly Lys Asn Leu Pro Val Leu Asp Gin Leu Thr Asp Pro Pro Gly Val 50 55 60

Lys Arg Val Tyr His Ile Gin Pro Ser Leu Glu Asp Pro Phe Gin Pro 65 70 75 80

Pro Ser Ile Pro Ile Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys 85 90 95 Arg Ser Val Leu Leu His Ala Pro Ser Glu Ala Pro Gin Ile Val Arg 100 105 110

Gly Ala Ser Asp Glu Ala Arg Lys His Thr Tyr Asn Leu Thr Ile Ala

115 120 125

Trp Tyr Arg Met Gly Asp Asn Cys Ala Ile Pro Ile Thr Val Met Glu 130 135 140

Tyr Thr Glu Cys Pro Tyr Asn Lys Ser Leu Gly Val Cys Pro Ile Arg 145 150 155 160

Thr Gin Pro Arg Trp Ser Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu 165 170 175 Asp Asn Leu Gly Phe Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly 180 185 190

Thr Tyr Leu Arg Leu Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gin 195 200 205 Phe Ile His Arg Ala Arg Ala Ser Cys Lys Tyr Ala Leu Pro Leu Arg

210 215 220

Ile Pro Pro Ala Ala Cys Leu, Thr Ser Lys Ala Tyr Gin Gin Gly Val 225 230 235 240 Thr Val Asp Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gin

245 250 255

Arg Thr Val Ala Lys Leu Lys Ile Ala Gly Trp His Gly Pro Lys Pro

260 265 270

Pro Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Asp Thr Thr Asn 275 280 285

Ala Thr Gin Pro Glu Leu Val Pro Glu Asp Pro Glu Asp Ser Ala Leu

290 295 300

Leu Glu Asp Pro Ala Gly Thr Val Ser Ser Gin Ile Pro Pro Asn Trp 305 310 315 320 His Ile Pro Ser Ile Gin Asp Val Ala Pro His His Ala Pro Ala Ala

325 330 335

Pro Ser Asn Pro Gly Leu Ile Ile Gly Ala Gly Ser Thr Leu Ala Val

340 345 350

Leu Val Ile Gly Gly Ile Ala Phe Trp Val Arg Arg Arg Ala Gin Met 355 360 365

Ala Pro Lys Arg Leu Arg Leu Pro His Ile Arg Asp Asp Asp Ala Pro

370 375 380

Pro Ser His Gin Pro Leu Phe Tyr 385 390

(2) INFORMATION FOR SEQ ID NO: 179:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 429 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 179:

Val Tyr Leu Trp Ala Arg Val Gly Gly Trp Leu Gly Tyr Leu Gly Gly 1 5 10 15 Thr Trp Thr Pro His Lys Gly Ser Leu Glu Gly Gly Lys Leu Gly Gin 20 25 30

Phe Ile Gly Arg Glu Arg Gly Ala Arg Thr Ala Val Pro Thr Ile Ser 35 40 45 His Arg Ala His Ser His Leu Asp Pro Ser Asp Pro Gly Met Pro Gly

50 55 60

Arg Ser Leu Gin Gly Leu Ala, Ile Leu Gly Leu Trp Val Cys Ala Thr 65 70 75 80 Gly Leu Val Val Arg Gly Pro Thr Val Ser Leu Val Ser Asp Ser Leu

85 90 95

Val Asp Ala Gly Ala Val Gly Pro Gin Gly Phe Val Glu Glu Asp Leu

100 105 110

Arg Val Phe Gly Glu Leu His Phe Val Gly Ala Gin Val Pro His Thr 115 120 125

Asn Tyr Tyr Asp Gly Ile Ile Glu Leu Phe His Tyr Pro Leu Gly Asn

130 135 140

His Cys Pro Arg Val Val His Val Val Thr Leu Thr Ala Cys Pro Arg 145 150 155 160 Arg Pro Ala Val Ala Phe Thr Leu Cys Arg Ser Thr His His Ala His

165 170 175

Ser Pro Ala Tyr Pro Thr Leu Glu Leu Gly Leu Ala Arg Gin Pro Leu

180 185 190

Leu Arg Val Arg Thr Ala Thr Arg Asp Tyr Ala Gly Val Leu Arg Val 195 200 205

Trp Val Gly Ser Ala Thr Asn Ala Ser Leu Phe Val Leu Gly Val Ser

210 215 220

Ala Asn Gly Thr Phe Val Tyr Asn Gly Ser Asp Tyr Gly Ser Cys Asp 225 230 235 _ 240 Pro Ala Gin Leu Pro Phe Ser Ala Pro Arg Leu Gly Pro Ser Ser Val

245 250 255

Tyr Thr Pro Gly Ala Ser Arg Pro Thr Pro Pro Arg Thr Thr Thr Ser

260 265 270

Pro Ser Ser Pro Arg Asp Pro Thr Pro Ala Pro Gly Asp Thr Gly Thr 275 280 285

Pro Ala Pro Ala Ser Gly Glu Arg Ala Pro Pro Asn Ser Thr Arg Ser

290 295 300

Ala Ser Glu Ser Arg His Arg Leu Thr Val Ala Gin Val Ile Gin Ile 305 310 315 320 Ala Ile Pro Ala Ser Ile Ile Ala Phe Val Phe Leu Gly Ser Cys Ile

325 330 335

Cys Phe Ile His Arg Cys Gin Arg Arg Tyr Arg Arg Pro Arg Gly Gin

340 345 350

Ile Tyr Asn Pro Gly Gly Val Ser Cys Ala Val Asn Glu Ala Ala Met 355 360 365

Ala Arg Leu Gly Ala Glu Leu Arg Ser His Pro Asn Thr Pro Pro Lys

370 375 380

Pro Arg Arg Arg Ser Ser Ser Ser Thr Thr Met Pro Ser Leu Thr Ser 385 390 395 400

Ile Ala Glu Glu Ser Glu Pro Gly Pro Val Val Leu Leu Ser Val Ser

405 - 410 415

Pro Arg Pro Arg Ser Gly Pro Thr Ala Pro Gin Glu Val 420 425

(2) INFORMATION FOR SEQ ID NO: 180:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 430 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 180:

Met Arg Ala Gly Leu Val Phe Phe Val Gly Val Trp Val Val Ser Cys 1 5 10 15

Leu Ala Ala Ala Pro Arg Thr Ser Trp Lys Arg Val Thr Ser Gly Glu

20 25 30

Asp Val Val Leu Leu Pro Ala Pro Ala Gly Pro Glu Glu Arg Thr Arg 35 40 45 Ala His Lys Leu Leu Trp Ala Ala Glu Pro Leu Asp Ala Cys Gly Pro 50 55 60

Leu Arg Pro Ser Trp Val Trp Pro Pro Arg Arg Val Leu Glu Thr Val 65 70 75 80

Val Asp Ala Ala Cys Met Arg Ala Pro Glu Pro Leu Ala Ile Ala Tyr 85 90 95

Ser Pro Pro Phe Pro Ala Gly Asp Glu Gly Ser Glu Leu Ala Trp Arg

100 105 110

Asp Arg Val Ala Val Val Asn Glu Ser Leu Val Ile Tyr Gly Ala Leu 115 120 125 Glu Thr Asp Ser Gly Thr Leu Ser Val Val Gly Leu Ser Asp Glu Ala 130 135 140

Arg Gin Val Ala Ser Val Val Leu Val Val Glu Pro Ala Pro Val Pro 145 150 155 160

Thr Pro Thr Pro Asp Asp Tyr Asp Glu Glu Asp Asp Ala Gly Val Ser 165 170 175

Thr Pro Val Ser Val Pro Pro Pro Thr Pro Pro Arg Arg Pro Pro Val

180 185 190

Ala Pro Pro Thr His Pro Arg Val Ile Pro Glu Val Ser His Val Arg 195 200 205

Gly Val Thr Val His Met Pro Glu Ala Ile Leu Phe Ala Pro Gly Glu

210 215- 220

Thr Phe Gly Thr Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gly 225 230 235 240

Pro Tyr Ala Met Asp Val Val Trp Met Arg Phe Asp Val Pro Ser Ser

245 250 255

Cys Ala Glu Met Arg Ile Tyr Glu Ala Cys Leu Tyr His Pro Gin Leu

260 265 270 Pro Glu Cys Leu Ser Pro Ala Asp Ala Pro Cys Ala Val Ser Ser Trp

275 280 285

Ala Tyr Arg Leu Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Thr

290 295 300

Pro Pro Pro Arg Cys Phe Ala Glu Ala Arg Met Glu Pro Val Pro Gly 305 310 315 320

Leu Ala Trp Leu Ala Ser Thr Val Asn Leu Glu Phe Gin His Asp Gin

325 330 335

His Ala Gly Leu Cys Val Val Tyr Val Asp Asp His Ile His Ala Trp

340 345 350 Gly His Met Thr Ile Ser Thr Ala Ala Gin Tyr Arg Asn Ala Val Val

355 360 365

Glu Gin His Leu Pro Gin Arg Gin Pro Glu Pro Val Glu Pro Trp His

370 375 380

Val Arg Ala Pro Pro Pro Ala Pro Ser Arg Pro Leu Arg Leu Gly Ala 385 390 395 400

Val Leu Gly Ala Ala Leu Leu Leu Ala Ala Leu Gly Leu Ser Ala Trp

405 410 415 Gly Val His Asp Leu Leu Ala Gin Ala Leu Leu Ala Gly Gly 420 425 430

(2) INFORMATION FOR SEQ ID NO: 181:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 181:

Val His Ala Val Asp Ala Pro Ser Gin Phe Val Thr Trp Leu Ala Val 1 5 10 15

Arg Trp Leu Arg Gly Ala Val Gly Leu Gly Ala Val Leu Cys Gly Ile

20 - 25 30

Ala Phe Tyr Val Thr Ser Ile Arg Ala 35 40

(2) INFORMATION FOR SEQ ID NO: 182:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 85 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 182:

Met Thr Ser Arg Pro Ala Asp Gin Asp Ser Val Arg Ser Ser Ala Ser 1 5 10 15

Val Pro Leu Tyr Pro Ala Asp Val Pro Ala Glu Ala Tyr Tyr Ser Glu

20 25 30

Ser Glu Asp Glu Ala Ala Asn Asp Phe Leu Val Arg Met Gly Arg Gin 35 40 45 Gin Ser Val Leu Arg Arg Arg Arg Arg Arg Thr Arg Cys Val Gly Leu 50 55 60

Val Ile Ala Cys Leu Val Val Leu Ser Gly Gly Phe Gly Ala Leu Leu 65 70 75 80

Val Trp Leu Leu Arg 85

(2) INFORMATION FOR SEQ ID NO: 183:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 296 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:183: Met Ile Arg Arg Arg Gly Asn Val Glu Ile Arg Val Tyr Tyr Glu Ser

1 5 10 15

Val Arg Pro Ser Arg Ser Arg.Ser His Leu Lys Pro Ser Asp His Gin 20 25 30 Glu Phe Pro Gly His His Val Ser Pro Gly Ser Pro Gly Phe Pro Glu 35 40 45

Ser Pro Gly Asn Arg Glu Phe His Asp Leu Pro Glu Asn Pro Gly Ser

50 55 60

Arg Ala Tyr Pro Gly Thr Arg Asp Pro His Asp Pro His Gly Cys Pro 65 70 75 80

Gly Ser Leu Asp Pro His Gly Asn Pro Ala Gin Pro Ala Gly Leu Pro

85 90 95

Ser Pro Val Pro Tyr Ala Pro Leu Gly Ser Pro Asp Pro Ser Ser Pro 100 105 110 Arg Gin Arg Thr Tyr Val Leu Pro Arg Val Gly Ile Arg Asn Ala Pro 115 120 125

Ala Ser Asp Thr Arg Ala Pro Lys Arg Ala His Ser Arg His Arg Ala

130 135 140

Asp Arg Pro Pro Glu Ser Pro Gly Ser Glu Leu Tyr Pro Leu Asn Ala 145 150 155 160

Gin Ala His Leu Gin Met Leu Pro Ala Asp His Arg Ala Phe Phe Arg

165 170 175

Thr Val Ile Glu Val Ser Arg Leu Cys Ala Leu Asn Thr His Asp Pro 180 185 190 Pro Pro Pro Leu Ala Gly Ala Arg Val Gly Gin Glu Ala Gin Leu Val 195 200 205

His Thr Gin Trp Leu Arg Ala Asn Arg Glu Ser Ser Pro Leu Trp Pro

210 215 220

Trp Arg Thr Ala Ala Met Asn Phe Ile Ala Ala Ala Ala Pro Cys Val 225 230 235 240

Gin Thr His Met His Asp Leu Leu Met Ala Cys Ala Phe Trp Cys Cys

245 250 255

Leu Ala His Ala Ser Thr Cys Ser Tyr Ala Gly Ser Ala His Cys Gin 260 265 270 His Leu Phe Arg Ala Phe Gly Cys Gly Pro Pro Val Leu Thr Thr Ser 275 280 285

Arg Gly Gin Gly Gly Trp Cys Asn 290 295

(2) INFORMATION FOR SEQ ID NO: 184:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 178 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear-

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 184:

ATGCACGTGT AACCGCCAGT CCGTGCTTGC CTAGCGAACT CACCCGTCCC GGCTGGCGTG 60

CGCAGCCCGG GCCGTGTTGC GGGCCCTCTT AAGGGGCGGC GGCAGGACGG GGACTCCGCC 120 CCGCCTCCTT TCCCCCGGGG AGTCAACCCC CGGGGGGGTG TATTCTGGGG GGGGGGT 178

(2) INFORMATION FOR SEQ ID NO: 185:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2116 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 185:

GACCCAGATC CCACCCCCGC CCGCAACGGG GCGCCGCCGC TGCTGCTGCT CCGCGGGGCG 60

CCAGGGGGCG CCGGTCGGGT CGCGGCGGGC TGGGAGGTTC CGCGGGTCGC CCCCGCACCG 120 CCGCCCCCGC GCCGGGGCGC TCTTCGGGGG GCGGGCGGGA CGTAGTCCGC TGCAGAGGGA 180

GACAGAGACG GGAACCCCCG GTTAGTGCCN GACCCCCGCC CGACCCCCGC CCAGTGCCCG 240

ACCCCCGCCC GACCCCCGCC CGACCCCCGC CCAGTGCCCG ACCCCCGCCC AGTGCCCGAC 300

CCCCGCCCAG TGCCCGACCC CCGCCCAGTG CCCGACCCCC GCCCGCCCTC ACCGTCGGCC 360

AGGTCATCGT CCTCGTCGTC CGTGCCGGGC CACGGGGGGG TGGGCGACAG GGCGCGGACC 420 GTGTGTCCCC CCAGCGACAG GGAGCGCGGG GCCGTCCGCG GGTTGCCCGT CCAGATAAAG 480

TCCACGGCCG TGCCGGACCG CACGGCCGCC TCGGCCTCCA CGCGGGTCCG GGGGTCGTTC 540

ACTATCGGGA TGGTGCTGAA CGACCCGCTG GCGGTCACGC CCACTATCAG GTACGCCACC 600

GGGGTGTTGC ACAGGGGACA CGTGTTGCGC AACGGAATCC AGGTCTTCAT GCACGGGATG 660

CAGAAGGGGT GCAGGCAGGG AAAACTCTGG CAGCGCAGGG GCGGGGCGAT CTCGTCCGTG 720 CACACGGCAC ACACGTCGCC CCCCCCTCCC GCTTCCGCTT CCTCCTCACC CACGGGCCCA 780

CCCCCGCAGG ATCCCTGCGC GTCGGCGGGC GTGGGGCTGC CCTGGCGCTC GGCCGGGGGC 840

CGGGCCGGGG GCGTGGCCGC GTCCATCAGG CCCGCCTCGA ACATCTCCGT GTCCGTGCTG 900

CCCGCCTCGG AGGTGGAGTC GCGGTGAAGG TCGTCGTCAG AGATTCCCAC CTCGGTCTCC 960

TCCTCCGAGT CGCTGCTGGC GAGCCACTGC ATGTCGTTGA GCATCCCCCA GGCGTGCGGG 1020 GCGGCGGGCT GCTTGACAAA GAAACGGGGG GGGATTTAGA GGGCGCGGGG CGTGAGGCGG 1080

GACCCCCGTG CCGTGTCCCC CGTGTCCCTC CCTCACCCCG GCCCCCCGCC CGCTGCTTTT 1140

TGTTCGGAAG GGGGGGAGAA AGGGGTCCGT AACCAAAGGT GGTCTGCGTC CTTTGGATTC 1200

CGACCCCTCG TCTCCCCCCC CCTGTCCCCC GCTCTCGGGC TCAGGGCTCC CTGCCTCCCT 1260 CGCCCCCCCA AAGGGTCGGG GGGCGGCGCA CGGCCCACGG GGGTCCCCCG ACCGCTTAAG 1320

CGGGCCGGGG GTCGGCCCCG TCAAGCGTCC CCGCCCCCGA GCCCACCGCC CGCGACCACC 1380

CCCAACCCGC AGCCGGGTGG TCCGGGGAAA AGGGGGGGCC TGAGACCCGG GGGTCGCCCT 1440

CTCACCGTGC CGGGGGTCTG CCGCGGCGGC CGCTCGGGGC CGGGGTCCGC CCGGGAGCTC 1500 GTGCCGGGCC GGGGTTCCAT GAGCCGGGGT AGGGTAGACT CGAGACGGCG GCCCGCGGTC 1560

TCTCTCTTGC CGGGTGTTAG TCTCTGTCTC TCCGGGTCTC CTCCTCCCGC CGGGCCGCCG 1620

CTCCGTCGCT CGCAGTGCCG GGGTGCGAAT GCGGCCCGAC CGTCACACGG GGCTGCCTTA 1680

TACCCGGCGC CTATCCACTC CCCCAAAGGG GCGGCATTTA CGATTCCCCC AATAGCCGCG 1740

CGCCCCGGCG GGGGCGGAGG GAGGGAATCC CCCCCTCTCG GGGCGGCCCC GTCCCCGGGG 1800 ACCAACCGGG TGTACTCCAA GAACCCCATT AGCATGCGCC GCCCCCCGCC GACGCAGATG 1860

GGAGTCCCCC CGGCGCCCCG CCGGCGCGGC CCTGAGTGGT GCCCGCCCCC GGGGAGAAAT 1920

TCATTAGCAT ACTAGGAAGC CCAGGGGACC AATAGGGGCC GATCAGCCCA CCCACCCGGC 1980

GGCGCGCGAG GCTCTGCGTG TTCTGCCAAG AAAGTAATCA GCATAACCCG GAACCCCGAG 2040

GGAGTAATTA CGCGGGGAGC GAGGGGCCGT CCGAACGTTT TTAATTACCA TAAGCGGGAA 2100 TGGCGGCCCG TTAAA 2116

(2) INFORMATION FOR SEQ ID NO: 186:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 338 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 186:

Met Leu Asn Asp Met Gin Trp Leu Ala Ser Ser Asp Ser Glu Glu Glu 1 5 10 15

Thr Glu Val Gly Ile Ser Asp Asp Asp Leu His Arg Asp Ser Thr Ser

20 25 30

Glu Ala Gly Ser Thr Asp Thr Glu Met Phe Glu Ala Gly Leu Met Asp 35 40 45 Ala Ala Thr Pro Pro Ala Arg Pro Pro Ala Glu Arg Gin Gly Ser Pro 50 55 60

Thr Pro Ala Asp Ala Gin Gly Ser Cys Gly Gly Gly Pro Val Gly Glu 65 70 75 80

Glu Glu Ala Glu Ala Gly Gly Gly Gly Asp Val Cys Ala Val Cys Thr 85 90 95

Asp Glu Ile Ala Pro Pro Leu Arg Cys Gin Ser Phe Pro Cys Leu His

100 105 110

Pro Phe Cys Ile Pro Cys Met Lys Thr Trp Ile Pro Leu Arg Asn Thr 115 120 125

Cys Pro Leu Cys Asn Thr Pro Val Ala Tyr Leu Ile Val Gly Val Thr 130 135 140

Ala Ser Gly Ser Phe Ser Thr Ile Pro Ile Val Asn Asp Pro Arg Thr

145 150 155 160

Arg Val Glu Ala Glu Ala Ala Val Arg Ser Gly Thr Ala Val Asp Phe 165 170 175

Ile Trp Thr Gly Asn Pro Arg Thr Ala Pro Arg Ser Leu Ser Leu Gly 180 185 190

Gly His Thr Val Arg Ala Leu Ser Pro Thr Pro Pro Trp Pro Gly Thr 195 200 205

Asp Asp Glu Asp Asp Asp Leu Ala Asp Gly Glu Gly Gly Arg Gly Ser

210 215 220

Gly Thr Gly Arg Gly Ser Gly Thr Gly Arg Gly Ser Gly Thr Gly Arg

225 230 235 240

Gly Ser Gly Thr Gly Arg Gly Ser Gly Gly Gly Arg Ala Gly Val Gly 245 250 255

His Trp Ala Gly Val Gly Arg Gly Xaa Gly Thr Asn Arg Gly Phe Pro

260 265 270

Ser Leu Ser Pro Ser Ala Ala Asp Tyr Val Pro Pro Ala Pro Arg Arg 275 280 285

Ala Pro Arg Arg Gly Gly Gly Gly Ala Gly Ala Thr Arg Gly Thr Ser

290 295 300

Gin Pro Ala Ala Trp Ala Pro Pro Gly Ala Pro Arg Ser Ser Ser Ser

305 310 315 320

Gly Gly Ala Pro Leu Arg Ala Gly Val Gly Ser Gly Ser Xaa Xaa Xaa 325 330 335

Xaa Xaa

(2) INFORMATION FOR SEQ ID NO: 187:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 642 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 187:

CGGCGGCGTT TCCGCGTTCC GTTTCTTCTC CCTCCCGGCC GCCCCGCTCC CGGGCCCGAC 60 CCTCGCCCCT TCCCTTCTCC TCGTCTTCCC CCGTCCCGCC GCGCCCCTTC CCTCTTCCTT 120 CTCTCTCTCT GTCTCGCTGT CTCGCTCTCC TCACATTTCC CCCCCCCCCC CCCGCCGCCG 180

CCGCCGCCCT CTGCCCGCGT CCCACCGAGA CGCCGCGCCG CGTGAGCCGT CCGCCGGGGG 240

ACCCAGGCTC CGGGGGGGGG GCGCGCCTGC GTGTGTCTCG TGTGAGAGAG CGCGCCCCTC 300

GAACGCCGCG CGTTCTCGCA GGTAGGTTTA GGGTCGTACA GGTGAGCTTC TGCTGAGGCG 360

GCGGGAGAGG GGGGGGCGGG CGGAAGAGAG AAGAGAGCAG GGGTTGGGGG AAAACTGTTC 420

TTCCTCCCCC TTTCAAGAAA CACGAGGCGG GGGTCCCAGA AAGGGCAGGC AGGTCAGCCG 480

CACCGCCCGC GAGCCAACCC GTATCCTTTT TTTCTAGGTG TTTTTGTTTT TGTTTCTGTT 540

TTTGTTTGTT TTGTTATTAT TTTCGCGGAT CCGGCGTGTT CGGATCCACC CCCCCCTTTC 600

TCCTTCCTCT TCCCTTCCAC CCACCCCCGT TTCCCCCCCC C 642

(2) INFORMATION FOR SEQ ID NO: 188:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 353 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 188:

CGCGCCCCCG CCCGGCCGCC GCGCGCCCCC GCCCGACCGC CGCGCGCCCC CGCCCGGCCG 60

CCGCGCGCCC CCGCCCGGCC GCCCGCGTCG CGCCGGCGCC CCCTCCCGGC GCTTCCGGGG 120

CCTTTCCTTC CTTCCCCGCC GCGACCCCGG CCCCGCCCCA CCGCCCCGCC CGGCAGGGGG 180 GCCCCGGCGC CGCGCAGAAC ACACAGACGA ACACACGGTG GCGATCTTTT CTTTACTTCG 240

GCAGACCAGC GAGCCCCGGC CCCGGCCCGC GCCCCGCCGC CACACCCACG GCACCCCCCC 300

CGCCGCCCAC CCCGGGGTCC ACACAGGAGC GCGCGGGCGG CAGAAACGCG GG 353

(2) INFORMATION FOR SEQ ID NO: 189:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6386 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 189:

CACGCGCCGC ATTTGCGCCC GGGGCCCCGC GCTCCCCCCG GGCGGCCTGG CCGTCGGGGG 60

CCAGATGTAC GTGAACCGCA ACGAGATCTT CAACGCCGCG CTGGCCGTTA CGAACATCAT 120

CCTGGATCTG GACATCGCCC TGAAGGAGCC CGTCCCCTTT CCCCGGCTCC ACGAGGCCCT 180

GGGTCACTTT AGGCGCGGGG CGCTGGCGGC GGTTCAGCTG TTGTTTCCCG CGGCCCGCGT 240 AGACCCCGAC GCCTATCCCT GTTATTTTTT CAAAAGCGCC TGTCGGCCCC GCGCGCCGCC 300 CGTCTGTGCG GGCGACGGGC CCTCGGCCGG TGGCGACGAC GGCGACGGGG ACTGGTTCCC 360 CGACGCCGGT GGCGACGACG GCGACGAGGA GTGGGAGGAG GACACGGACC CCATGGACAC 420 GACCCACGGC CCCCTCCCGG ACGACGAGGC CGCGTACCTC GACCTGCTAC ACGAACAGAT 480 ACCAGCGGCG ACGCCCAGCG AACCGGACTC CGTCGTGTGT TCCTGCGCCG ACAAGATCGG 540 GCTGCGCGTG TGCCTACCGG TCCCCGCCCC GTACGTTGTG CACGGCTCCC TGACGATGCG 600 TGGGGTGGCG AGGGTGATCC AGCAGGCGGT GCTGTTGGAC CGCGACTTCG TGGAGGCCGT 660 AGGGAGCCAC GTAAAGAACT TTTTGCTGAT CGATACGGGC GTGTACGCCC ACGGCCACAG 720 CCTGCGCTTG CCGTATTTCG CCAAGATCGG CCCCGACGGC TCCGCGTGCG GCCGGTTATT 780 GCCCGTCTTC GTGATCCCCC CCGCGTGCGA GGACGTTCCG GCGTTCGTCG CCGCGCACGC 840 CGACCCGCGG CGCTTCCACT TTCACGCCCC GCCCATGTTT TCCGCGGCCC CGCGGGAGAT 900 CCGCGTCCTC CACAGCCTGG GCGGGGACTA TGTCAGCTTT TTCGAGAAGA AGGCGTCGCG 960

CAACGCCCTG GAGCACTTTG GGCGACGCGA GACCCTGACG GAGGTTCTGG GCCGCTACGA 1020

TGTGCGGCCC GACGCCGGGG AGACCGTGGA GGGGTTCGCG TCAGAACTGC TGGGGCGAAT 1080 AGTCGCGTGC ATCGAGGCCC ACTTTCCCGA GCACGCGCGG GAATATCAGG CCGTGTCCGT 1140

TCGCCGGGCC GTCATTAAGG ACGACTGGGT CCTGCTGCAG CTGATCCCCG GCCGCGGCGC 1200

CCTGAACCAA AGCCTCTCGT GTCTGCGCTT CAAGCACGGC AGGGCAAGTC GCGCGACGGC 1260

CCGGACCTTT CTCGCGCTGA GCGTCGGGAC CAACAACCGC CTATGCGCGT CCCTGTGTCA 1320

GCAGTGCTTT GCCACTAAAT GCGATAACAA CCGCCTGCAC ACGCTGTTTA CCGTCGATGC 1380 GGGCACGCCA TGCTCGCGGT CCGCTCCCTC CAGCACCTCA CGACCGTCAT CTTCATAACG 1440

GCCTACGGCC TCGTGCTCGC GTGGTACATC GTCTTTGGTG CCAGTCCGCT CCACCGATGT 1500

ATTTACGCGG TGCGCCCCGC CGGGGCACAC AACGATACCG CCCTCGTGTG GATGAAGATA 1560

AACCAGACGC TGTTGTTTCT GGGCCCGCCG ACCGCCCCCC CCGGCGGGGC ATGGACCCCC 1620

CACGCCCACG TCTGCTACGC CAATATCATC GAAGGTCGGG CCGTGTCCCT CCCGGCCATC 1680 CCCGGCGCCA TGAGCCGCCG GGTCATGAAC GTGCACGAGG CCGTAAACTG CTTGGAGGCC 1740

CTCTGGGACA CCCAGATGCG CCTGGTGGTC GTCGGTTGGT TTCTGTATCT AGCGTTCGTC 1800

GCCCTTCACC AACGACGATG CATGTTCGGC GTCGTGAGTC CCGCGCACAG CATGGTGGCC 1860

CCGGCGACCT ATCTTTTGAA CTACGCCGGC CGCATAGTGT CGAGCGTGTT CTTGCAATAC 1920

CCCTACACGA AAATCACCCG CCTCCTCTGC GAGCTATCCG TTCAACGCCA GACCCTGGTG 1980 CAGCTGTTCG AGGCGGATCC GGTCACCTTC TTGTACCACC GCCCGGCCGT TGGCGTCATC 2040

GTGGGCTGCG AGCTGCTGCT CCGCTTCGTG GCCCTCGGTC TCATCGTCGG CACCGCTCTC 2100

ATCTCCCGGG GCGCCTGCGC GATCACATAC CCCCTGTTTC TAACAATCAC CACCTGGTGT 2160

TTCGTGTCCA TCATCGCCCT GACGGAGCTG TATTTCATCC TGCGGCGGGA CTCGGCCCCC 2220

AAAAACGCGG AACCAGCGGC CCCCAGGGGG CGCTCCAAAG GGTGGTCGGG CGTCTGCGGG 2280 CGCTGCTGTT CCATCATCCT CTCCGGTATC GCCGTGCGCC TGTGCTATAT CGCCGTCGTG 2340

GCCGGGGTGG TGCTTATGGC GCTTCGCTAC GAACAGGAGA TTCAGCGGCG CCTGTTTGAT 2400

CTGTGACGTA ACGCCTCTTC CGTTGGAAGA GGCGGACCCA GTCGCCCATG CAAATTAAAT 2460

ACACGACCCG CCTCGGGCCT ACGCACCCTC GCACGTCGCA TGCAAATTAA AATCGTGCAC 2520

AGAGCCGATC CGGCCTCGGG TCTGCTTGCC CCTCCCCCGG TCCAGCACAG GCAGGCTCGT 2580 CCGACTTCCG CATACACCCC ACCCTACCGC GTGCTTCCGC ACCCCCGCCT ACGCGTGTAC 2640

GCGAAGGCGG ACCCAGACCT GCCGTATGCT AATTAAATAC ATAAAACCCA CCCTCGGCGT 2700

CCGATTGGTT TCTGGGGACG GCGGGGGCGG GGGCGGTGAC GCCCGACGGG GAGGGACAAG 2760

GAGGAGTTTC GGAAAGCCGG CCCCGGTCGT GCGGGTATAA GGGCAGCCAC CGGCCCACTG 2820 GGCGCTGTGT GCTGCCGTGT GCCGACCCCG GTTGCGCGTC GGTGCCGCTC CTCGATTCGG 2880

ACCCGGCCAC TCTCTTCCGA CACGCGCCCC CTCGGAGGAC ACCCGCCATC CCAGCCCCGG 2940

CGACCTACAA CATGGCTACC GACATTGATA TGCTAATCGA CCTAGGATTG GACCTGTCCG 3000

ACAGCGAGCT CGAGGAGGAC GCTCTGGAGC GGGACGAGGA GGGCCGCCGC GACGACCCCG 3060 AGTCCGACAG CAGCGGGGAG TGTTCCTCGT CGGACGAGGA CATGGAAGAC CCCTGCGGAG 3120

ACGGAGGGGC GGAGGCCATC GACGCGGCGA TTCCCAAAGG TCCCCCGGCC CGCCCCGAGG 3180

ACGCCGGCAC CCCCGAAGCC TCGACGCCTC GCCCGGCAGC GCGGCGGGGA GCCGACGATC 3240

CGCCACCCGC GACCACCGGC GTGTGGTCGC GCCTCGGGAC CAGGCGGTCG GCTTCCCCCC 3300

GGGAACCGCA CGGGGGGAAG GTGGCCCGCA TCCAACCCCC GTCGACCAAG GCACCGCATC 3360 CCCGAGGCGG GCGGCGAGGT CGCCGCCGGG GCCGGGGTCG ATACGGCCCC GGCGGCGCCG 3420

ACTCCACACC AAACCCCCGC CGGCGCGTCT CCAGAAACGC CCACAACCAA GGGGGTCGCC 3480

ACCCCGCGTC GGCGCGGACG GACGGCCCCG GCGCCACCCA CGGCGAGGCG CGGCGCGGAG 3540

GGGAGCAGCT CGACGTCTCC GGGGGCCCGC GGCCACGAGG CACGCGCCAG GCCCCCCCTC 3600

CGCTGATGGC GCTGTCCCTG ACCCCCCCGC ACGCGGACGG CCGCGCCCCG GTCCCGGAGC 3660 GAAAGGCGCC CTCTGCCGAC ACCATCGACC CCGCCGTTCG GGCGGTTCTG CGATCCATAT 3720

CCGAGCGCGC GGCGGTCGAG CGCATCAGCG AAAGCTTTGG ACGCAGTGCC CTGGTCATGC 3780

AAGACCCCTT TGGCGGGATG CCGTTTCCCG CCGCGAACAG CCCCTGGGCT CCCGTGCTGG 3840

CCACCCAAGC GGGGGGGTTT GACGCCGAGA CCCGTCGGGT TTCCTGGGAA ACCCTGGTCG 3900

CTCACGGCCC GAGCCTCTAC CGCACATTCG CAGCCAACCC GCGGGCCGCG TCGACAGCCA 3960 AGGCCATGCG CGACTGCGTG CTGCGCCAGG AAAATCTCAT CGAGGCCCTG GCGTCCGCGG 4020

ATGAGACGCT GGCGTGGTGC AAGATGTGCA TTCACCACAA TCTGCCGCTC CGCCCCCAGG 4080

ACCCTATCAT CGGAACGGCG GCCGCCGTGC TGGAAAACCT CGCCACGCGC CTGCGCCCCT 4140

TTCTGCAGTG CTACCTGAAG GCCCGAGGCC TGTGCGGGCT GGACGACCTG TGCTCGCGGC 4200

GACGCCTGTC GGACATTAAG GATATTGCCT CCTTTGTGTT GGTCATCCTG GCCCGCCTCG 4260 CCAACCGCGT CGAGCGCGGC GTGTCGGAGA TCGACTACAC GACCGTGGGG GTTGGGGCCG 4320

GCGAGACGAT GCACTTTTAC ATCCCGGGGG CCTGCATGGC GGGTCTCATT GAAATACTGG 4380

ACACGCACCG CCAGGAGTGT TCCAGTCGCG TGTGCGAGCT GACGGCCAGT CACACTATCG 4440

CCCCCTTATA TGTGCACGGC AAATACTTCT ACTGCAACTC CCTATTTTAG GCAAGAATAA 4500

ACATATTGAC GTCAACCCAA GTGGTTCCGT GTGATGTTCT TGGCGCGCGC GGCGGGTGGG 4560 GCGGAGACTC CGGGGCGATG CCGGCGTGCG CGTGGGAGGA GGGCGATGAC CCACCGGATA 4620

AATGTGGGGC CCCGGCCCGG CCCGCTTCAT AGCGCGTCCA GGAACTCACG GCAGACGCGT 4680

ATTCACCGAC CCCCCCCCTC GCAACATGAC AACGACGCCC CTCTCGAACC TGTTTTTACG 4740

GGCCCCGGAC ATCACCCACG TCGCCCCCCC GTACTGTCTG AATGCCACGT GGCAGGCCGA 4800

AAACGCCCTG CACACGACCA AAACGGACCC CGCGTGCCTG GCCGCGCGGA GTTATTTAGT 4860 CCGCGCCTCC TGCTCGACCA GCGGCCCCAT CCACTGTTTT TTCTTTGCGG TGTACAAGGA 4920

CTCGCAGCAC TCCCTTCCGC TGGTTACCGA GCTCCGCAAC TTCGCGGACC TGGTCAACCA 4980

CCCGCCCGTC TTGCGCGAAC TAGAGGATAA GCGTGGGGGG CGGCTGCGGT GCACGGGCCC 5040

ATTCAGCTGC GGAACCATCA AGGACGTCTC CGGTGCATCC CCCGCGGGGG AATACACGAT 5100

AAACGGTATC GTGTACCACT GTCACTGTCG GTATCCGTTC TCCAAAACCT GCTGGCTCGG 5160 GGCATCCGCG GCCCTACAAC ACCTTCGCTC TATAAGCTCA AGCGGCACGG CCGCTCGCGC 5220

GGCAGAACAG CGACGCCACA AAATCAAAAT CAAAATCAAG GTATAACCCA CCCCCTTCCC 5280

TCCGAGTCCG TATGCAACCT CATTAATAAA GAGTGAGAAC CAACCAAAAC AGACGCGGTG 5340

TGAGTTTGTG GGTTATAGGA ACCCGGTAAA TACCACGCGA CGAACCAGCG TGTGTGTTAA 5400 CGCGACTTTT ATTCGTTGTA TCGCGGGAGG GGGGAAGCTT ACCGCCAAAG GAAGGCCAAG 5460

ATGATAACGA CGACCACCGC GACCACCCCA AAAACCGCAT GACGACACGT CCCGCCACAC 5520

CACCCTGGGG CTTGGGGCGT GTCGGAGCTC GACGCACAGC GGGCCGCGCG TTGGGCCCGG 5580

TACAGCTCTC GCGAATTGAC GAGCGGGGGT CGCCACGTGC GCGAGCTTTG CACGCGGGGT 5640 TGGTCGGCCG GCCCCACGGA CCCGCCCGGT GGCTCGGTCG GACATGCGGC CATGACCATG 5700

GCGTAGGTGG GGGGGCGATC CGAGGTCGCC TCTGCGTAAG TAGGGAGGCC CGACGGGAGG 5760

TCGCCTCCCA CGCCAGGGTG GGCCCCAATC ATAGTTTCCG GTAGAAACAG GGGGGTCTCC 5820

ACAAACAACC CCCCTGGGCC AAAGCTCCGG CGCCGCGCCC GTCGTTCGGC GCGGCGCCTG 5880

GCGCGCCGAG CGGCCCGCCA GGCGGCGCGG CGCGAGCGGC CACGCTCACA CACCTCGCCG 5940 TCACCGGAAG AAGCCGGTGA AACAAGCCCA ACCGGCGACG TCCCTGCAGA GTACGGTGGA 6000

GGCGAGTCCG TGGGGGTGTC GATATCAATA ACGACAAACT GGCCCGCGCT CGCGCCGGCC 6060

ACACTCTCGT ATGGGGGCGG GGCGTCAATC ACGCTATCAT CTCCGTCATC CCTGCATGCG 6120

TGGGCATGCC CAGCCCCCAA CGCCATGGTG GGGATTCGCG GCTCAGAAGC CTGCATGTCG 6180

TGTGGTCGGT CGTAGTCCAA CGTGCCTCCC CCACCCACCA CACAGCCGGT CCCCACGCCG 6240 ACCACTAGAC CGCAGACGTC GCCCAACCGA GGTCCCCGTG CACAGACCGC GCCTTTTATA 6300

GCCCCAGGGG TTGCTAATTA ACGCACGCAT GCAGACGCAA TTTATTTTGC TCCCCCGCGT 6360

CCTCCCCTCC CCCGCGTCCT CCCNT 6386

(2) INFORMATION FOR SEQ ID NO: 190:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 477 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 190:

Xaa Xaa Xaa Xaa Xaa Thr Arg Arg Ile Cys Arg Pro Ala Leu Pro Pro

1 5 10 15

Gly Gly Leu Ala Val Gly Gly Gin Met Tyr Val Asn Arg Asn Glu Ile 20 25 30 Phe Asn Ala Ala Val Thr Asn Ile Ile Leu Asp Leu Asp Ile Ala Leu 35 40 45

Lys Glu Pro Val Pro Phe Pro Arg Leu His Glu Ala Leu Gly His Phe

50 55 60

Arg Arg Gly Ala Ala Val Gin Leu Leu Phe Pro Ala Ala Arg Val Asp 65 70 75 80

Pro Asp Ala Tyr Pro Cys Tyr Phe Phe Lys Ser Ala Cys Arg Pro Arg

85 90 95

Ala Pro Pro Val Cys Ala Gly Asp Gly Pro Ser Ala Gly Gly Asp Asp 100 105 110

Gly Asp Gly Asp Trp Phe Pro Asp Ala Gly Gly Asp Asp Gly Asp Glu

115 120 125

Glu Trp Glu Glu Asp Thr Asp Pro Met Asp Thr Thr His Gly Pro Leu 130 135 140

Pro Asp Asp Glu Ala Ala Tyr Leu Asp Leu Leu His Glu Gin Ile Pro

145 150 155 160

Ala Ala Thr Pro Ser Glu Pro Asp Ser Val Val Cys Ser Cys Ala Asp

165 170 175 Lys Ile Gly Leu Arg Val Cys Leu Pro Val Pro Ala Pro Tyr Val Val

180 185 190

His Gly Ser Leu Thr Met Arg Gly Val Ala Arg Val Ile Gin Gin Ala

195 200 205

Val Leu Leu Asp Arg Asp Phe Val Glu Ala Val Gly Ser His Val Lys 210 215 220

Asn Phe Leu Leu Ile Asp Thr Gly Val Tyr Ala His Gly His Ser Leu

225 230 235 240

Arg Leu Pro Tyr Phe Ala Lys Ile Gly Pro Asp Gly Ser Ala Cys Gly

245 250 255 Arg Leu Leu Pro Val Phe Val Ile Pro Pro Ala Cys Glu Asp Val Pro

260 265 270

Ala Phe Val Ala Ala His Ala Asp Pro Arg Arg Phe His Phe His Ala

275 280 285

Pro Pro Met Phe Ser Ala Ala Pro Arg Glu Ile Arg Val Leu His Ser 290 295 300

Leu Gly Gly Asp Tyr Val Ser Phe Phe Glu Lys Lys Ala Ser Arg Asn

305 310 315 320

Ala Leu Glu His Phe Gly Arg Arg Glu Thr Leu Thr Glu Val Leu Gly

325 330 335 Arg Tyr Asp Val Arg Pro Asp Ala Gly Glu Thr Val Glu Gly Phe Ala

340 345 350

Ser Glu Leu Leu Gly Arg Ile Val Ala Cys Ile Glu Ala His Phe Pro

355 360 365

Glu His Ala Arg Glu Tyr Gin Ala Val Ser Val Arg Arg Ala Val Ile 370 375 380

Lys Asp Asp Trp Val Leu Leu Gin Leu Ile Pro Gly Arg Gly Ala Leu 385 390 395 400

Asn Gin Ser Leu Ser Cys Leu Arg Phe Lys His Gly Arg Ala Ser Arg 405 410 415 Ala Thr Ala Arg Thr Phe Leu Ala Leu Ser Val Gly Thr Asn Asn Arg 420 425 430

Leu Cys Ala Ser Leu Cys Gin Gin Cys Phe Ala Thr Lys Cys Asp Asn 435 440 445 Asn Arg Leu His Thr Leu Phe Thr Val Asp Ala Gly Thr Pro Cys Ser

450 455 460

Arg Ser Ala Pro Ser Ser Thr Ser Arg Pro Ser Ser Ser 465 470 475

(2) INFORMATION FOR SEQ ID NO: 191:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 332 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 191:

Met Leu Ala Val Arg Ser Leu Gin His Leu Thr Thr Val Ile Phe lie 1 5 10 15 Thr Ala Tyr Gly Leu Val Leu Ala Trp Tyr Ile Val Phe Gly Asp Leu 20 25 30

His Arg Cys Ile Tyr Ala Val Arg Pro Ala Gly Ala His Asn Asp Thr

35 40 45

Ala Leu Val Trp Met Lys Ile Asn Gin Thr Leu Leu Phe Leu Gly Pro 50 55 60

Pro Thr Ala Pro Pro Gly Gly Ala Trp Thr Pro His Ala His Val Cys 65 70 75 80

Tyr Ala Asn Ile Ile Glu Gly Arg Ala Val Ser Leu Pro Ala Ile Pro 85 90 95 Gly Ala Met Ser Arg Arg Val Met Asn Val His Glu Ala Val Asn Cys 100 105 110

Leu Glu Ala Leu Trp Asp Thr Gin Met Arg Leu Val Val Val Gly Trp

115 120 125

Phe Leu Tyr Leu Ala Phe Val His Gin Arg Arg Cys Met Phe Gly Val 130 135 140

Val Ser Pro Ala His Ser Met Val Ala Pro Ala Thr Tyr Leu Leu Asn 145 150 155 160

Tyr Ala Gly Arg Ile Val Ser Ser Val Phe Leu Gin Tyr Pro Tyr Thr 165 170 175 Lys Ile Thr Arg Leu Leu Cys Glu Leu Ser Val Gin Arg Gin Thr Leu 180 185 190

Val Gin Leu Phe Glu Ala Asp Pro Val Thr Phe Leu Tyr His Arg Pro 195 200 205 Ala Val Gly Val Ile Val Gly Cys Glu Leu Leu Leu Arg Phe Val Gly

210 215 220

Leu Ile Val Gly Thr Ala Leu Ile Ser Arg Gly Ala Cys Ala Ile Thr 225 230 235 240 Tyr Pro Leu Phe Leu Thr Ile Thr Thr Trp Cys Phe Val Ser Ile Ile

245 250 255

Ala Leu Thr Glu Leu Tyr Phe Ile Leu Arg Arg Asp Ser Ala Pro Lys

260 265 270

Asn Ala Glu Pro Ala Ala Pro Arg Gly Arg Ser Lys Gly Trp Ser Gly 275 280 285

Val Cys Gly Arg Cys Cys Ser Ile Ile Leu Ser Gly Ile Ala Val Arg

290 295 300

Leu Cys Tyr Ile Ala Val Val Ala Gly Val Val Leu Met Ala Leu Arg 305 310 315 320 Tyr Glu Gin Glu Ile Gin Arg Arg Leu Phe Asp Leu

325 330

(2) INFORMATION FOR SEQ ID NO: 192:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 574 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 192:

Val Thr Pro Asp Gly Glu Gly Gin Gly Gly Val Ser Glu Ser Arg Pro 1 5 10 15

Arg Ser Cys Gly Tyr Lys Gly Ser His Arg Pro Thr Gly Arg Cys Val

20 25 30

Leu Pro Cys Ala Asp Pro Gly Cys Ala Ser Val Pro Leu Leu Asp Ser 35 40 45

Asp Pro Ala Thr Leu Phe Arg His Ala Pro Pro Arg Arg Thr Pro Ala

50 55 60

Ile Pro Ala Pro Ala Thr Tyr Asn Met Ala Thr Asp Ile Asp Met Leu 65 70 75 80 Ile Asp Leu Gly Leu Asp Leu Ser Asp Ser Glu Leu Glu Glu Asp Ala

85 90 95

Leu Glu Arg Asp Glu Glu Gly Arg Arg Asp Asp Pro Glu Ser Asp Ser 100 105 110 Ser Gly Glu Cys Ser Ser Ser Asp Glu Asp Met Glu Asp Pro Cys Gly

115 120 125

Asp Gly Gly Ala Glu Ala Ile Asp Ala Ala Ile Pro Lys Gly Pro Pro

130 135 140 Ala Arg Pro Glu Asp Ala Gly Thr Pro Glu Ala Ser Thr Pro Arg Pro

145 150 155 160

Ala Ala Arg Arg Gly Ala Asp Asp Pro Pro Pro Ala Thr Thr Gly Val

165 170 175

Trp Ser Arg Leu Gly Thr Arg Arg Ser Asp Arg Glu Pro His Gly Gly 180 185 190

Lys Val Ala Arg Ile Gin Pro Pro Ser Thr Lys Ala Pro His Pro Arg

195 200 205

Gly Gly Arg Arg Gly Arg Arg Arg Gly Arg Gly Arg Tyr Gly Pro Gly

210 215 220 Gly Ala Asp Ser Thr Pro Asn Pro Arg Arg Arg Val Ser Arg Asn Ala

225 230 235 240

His Asn Gin Gly Gly Arg His Pro Ala Ser Ala Arg Thr Asp Gly Pro

245 250 255

Gly Ala Thr His Gly Glu Ala Arg Arg Gly Gly Glu Gin Leu Asp Val 260 265 270

Ser Gly Gly Pro Arg Pro Arg Gly Thr Arg Gin Ala Pro Pro Pro Leu

275 280 285

Met Ala Leu Ser Leu Thr Pro Pro His Ala Asp Gly Arg Ala Pro Val

290 295 300 Pro Glu Arg Lys Ala Pro Ser Ala Asp Thr Ile Asp Pro Ala Val Arg

305 310 315 320

Ala Val Leu Arg Ser Ile Ser Ala Ala Val Glu Arg lie Ser Glu Ser

325 330 335

Phe Gly Arg Ser Ala Leu Val Met Gin Asp Pro Phe Gly Gly Met Pro 340 345 350

Phe Pro Ala Ala Asn Ser Pro Trp Ala Pro Val Leu Ala Thr Gin Ala

355 360 365

Gly Gly Phe Asp Ala Glu Thr Arg Arg Val Ser Trp Glu Thr Leu Val

370 375 380 Ala His Gly Pro Ser Leu Tyr Arg Thr Phe Ala Ala Asn Pro Arg Ala

385 390 395 400

Ala Ser Thr Ala Lys Ala Met Arg Asp Cys Val Leu Arg Gin Glu Asn

405 410 415

Leu Ile Glu Ala Ser Ala Asp Glu Thr Leu Ala Trp Cys Lys Met Cys 420 425 430

Ile His His Asn Leu Pro Leu Arg Pro Gin Asp Pro Ile Ile Gly Thr

435 440 445

Ala Ala Ala Val Leu Glu Asn Leu Ala Thr Arg Leu Arg Pro Phe Leu 450 455 460

Gin Cys Tyr Leu Lys Arg Leu Cys Gly Leu Asp Asp Leu Cys Ser Arg 465 470 . 475 480

Arg Arg Leu Ser Asp lie Lys Asp Ile Ala Ser Phe Val Leu Val Ile 485 490 495

Leu Ala Arg Leu Ala Asn Arg Val Glu Arg Gly Val Ser Glu Ile Asp

500 505 510

Tyr Thr Thr Val Gly Val Gly Ala Gly Glu Thr Met His Phe Tyr Ile 515 520 525 Pro Gly Ala Cys Met Ala Gly Leu Ile Glu Ile Leu Asp Thr Gin Glu 530 535 540

Cys Ser Ser Arg Val Cys Glu Leu Thr Ala Ser His Thr Ile Ala Pro 545 550 555 560

Leu Tyr Val His Gly Lys Tyr Phe Tyr Cys Asn Ser Leu Phe 565 570

(2) INFORMATION FOR SEQ ID NO: 193:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 212 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:193:

Met Trp Gly Pro Gly Pro Ala Arg Phe Ile Ala Arg Pro Gly Thr His 1 5 10 15

Gly Arg Arg Val Phe Thr Asp Pro Pro Pro Arg Asn Met Thr Thr Thr

20 25 30

Pro Leu Ser Asn Leu Phe Leu Arg Ala Pro Asp Ile Thr His Val Ala 35 40 45 Pro Pro Tyr Cys Leu Asn Ala Thr Trp Gin Ala Glu Asn Ala Leu His 50 55 60

Thr Thr Lys Thr Asp Pro Ala Cys Leu Ala Ala Arg Ser Tyr Leu Val 65 70 75 80

Arg Ala Ser Cys Ser Thr Ser Gly Pro Ile His Cys Phe Phe Phe Ala 85 90 95

Val Tyr Lys Asp Ser Gin His Ser Leu Pro Leu Val Thr Glu Leu Arg

100 105 110

Asn Phe Ala Asp Leu Val Asn His Pro Pro Val Leu Arg Glu Leu Glu 115 120 125

Asp Lys Arg Gly Gly Arg Leu Arg Cys Thr Gly Pro Phe Ser Cys Gly

130 135. 140

Thr Ile Lys Asp Val Ser Gly Asp Ala Gly Glu Tyr Thr Ile Asn Gly 145 150 155 160

Ile Val Tyr His Cys His Cys Arg Tyr Pro Phe Ser Lys Thr Cys Trp

165 170 175

Leu Gly Ala Ser Ala Ala Leu Gin His Leu Arg Ser Ile Ser Ser Ser 180 185 190 Gly Thr Ala Ala Arg Ala Ala Glu Gin Arg Arg His Lys Ile Lys Ile 195 200 205

Lys Ile Lys Val 210

(2) INFORMATION FOR SEQ ID NO: 194:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 117 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 194:

Met Ile Gly Ala His Pro Gly Val Gly Gly Asp Leu Pro Ser Gly Leu

1 5 10 15

Pro Thr Tyr Ala Glu Ala Thr Ser Asp Arg Pro Pro Thr Tyr Ala Met 20 25 30

Val Met Ala Ala Cys Pro Thr Glu Pro Pro Gly Gly Ser Val Gly Pro

35 40 45

Ala Asp Gin Pro Arg Val Gin Ser Ser Arg Thr Trp Arg Pro Pro Leu 50 55 60 Val Asn Ser Arg Glu Leu Tyr Arg Ala Gin Arg Ala Ala Arg Cys Ala 65 70 75 80

Ser Ser Ser Asp Thr Pro Gin Ala Pro Gly Trp Cys Gly Gly Thr Cys

85 90 95

Arg His Ala Val Phe Gly Val Val Ala Val Val Val Val Ile Ile Leu 100 105 110

Ala Phe Leu Trp Arg 115 (2) INFORMATION FOR SEQ ID NO: 195:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3699 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 195:

GGGGGCCACG CGGCGGCGGG CCTGACGGAG CTGTGTCAGA CCCTCGCGCC CCGGGACCTC 60

ACGGACCCGC TGCTGTTTGC GTACGTCGGA TTCCAGGTCG TGAACCACGG GCTGATGTTT 120

GTGGTCCCCG ACATCGCCGT ATACGCGATG CTGGGGGGCG CCGTGTGGAT CTCGCTGACG 180 CAGGTGCTTG GGCTCCGGCG CCGCCTTCAC AAGGACCCAG ACGCCGGGCC CTGGGCGGCC 240

GCGACCCTGC GGGGCCTCTT TTTCTCCGTC TACGCATTGG GGTTTGCGGC GGGGGTGCTG 300

GTGCGGCCGC GGATGGCGGC GAGCCGGCGG TCGGGGTGAT CGCCATTTCA AATAAAAGGC 360

ACGAGTTCCC CGAATACCAC CGGCGTGTGA TGATTTCGCC CTACCGCTCC GATCCCCGGG 420

GGGAGGGGGG AAGGAAATGG GCGCGGGGGT GCCGTGGACG GGTATAAAGG CCAGGGGGGC 480 AGGCGGGCCC ATCACTGTTA GGGTGTTAGG TTGGGAGGTG GCACAAAAAG CGACACACCC 540

GTGTTGTAGT TGTCCGCGGG AGGCGGTGGT TTCCGGCAAC CCTCCTCGCT GCGCCGGGCG 600

CGCCCACCGG TCCTTCGCGG GGGCCGGGGC TCTTCTGGTC ATGGCCCTTG GACGGGTGGG 660

CCTAGCCGTG GGCCTGTGGG GCCTGCTGTG GGTGGGTGTG GTCGTGGTGC TGGCCAATGC 720

CTCCCCCGGA CGCACGATAA CGGTGGGCCC GCGGGGGAAC GCGAGCAATG CCGCCCCCTC 780 CGCGTCCCCG CGGAACGCAT CCGCCCCCCG AACCACACCC ACGCCCCCCC AACCCCGCAA 840

GGCGACGAAA AGTAAGGCCT CCACCGCCAA ACCGGCCCCG CCCCCCAAGA CCGGGCCCCC 900

GAAGACATCC TCGGAGCCCG TGCGATGCAA CCGCCACGAC CCGCTGGCCC GGTACGGCTC 960

GCGGGTGCAA ATCCGATGCC GGTTTCCCAA CTCCACCCGC ACGGAGTCCC GCCTCCAGAT 1020

CTGGCGTTAT GCCACGGCGA CGGACGCCGA GATCGGAACG GCGCCTAGCT TAGAGGAGGT 1080 GATGGTAAAC GTGTCGGCCC CGCCCGGGGG CCAACTGGTG TATGACAGCG CCCCCAACCG 1140

AACGGACCCG CACGTGATCT GGGCGGAGGG CGCCGGCCCG GGCGCCAGCC CGCGGCTGTA 1200

CTCGGTCGTC GGGCCGCTGG GTCGGCAGCG GCTCATCATC GAAGAGCTGA CCCTGGAGAC 1260

CCAGGGCATG TACTACTGGG TGTGGGGCCG GACGGACCGC CCGTCCGCGT ACGGGACCTG 1320

GGTGCGCGTT CGCGTGTTCC GCCCTCCGTC GCTGACCATC CACCCCCACG CGGTGCTGGA 1380 GGGCCAGCCG TTTAAGGCGA CGTGCACGGC CGCCACCTAC TACCCGGGCA ACCGCGCGGA 1440

GTTCGTCTGG TTCGAGGACG GTCGCCGGGT ATTCGATCCG GCCCAGATAC ACACGCAGAC 1500

GCAGGAGAAC CCCGACGGCT TTTCCACCGT CTCCACCGTG ACCTCCGCGG CCGTCGGCGG 1560

CCAGGGCCCC CCGCGCACCT TCACCTGCCA GCTGACGTGG CACCGCGACT CCGTGTCGTT 1620

CTCTCGGCGC AACGCCAGCG GCACGGCATC GGTGCTGCCG CGGCCAACCA TTACCATGGA 1680 GTTTACGGGC GACCATGCGG TCTGCACGGC CGGCTGTGTG CCCGAGGGGG TGACGTTTGC 1740

CTGGTTCCTG GGGGACGACT CCTCGCCGGC GGAGAAGGTG GCCGTCGCGT CCCAGACATC 1800

GTGCGGGCGC CCCGGCACCG CCACGATCCG CTCCACCCTG CCGGTCTCGT ACGAGCAGAC 1860

CGAGTACATC TGCCGGCTGG CGGGATACCC GGACGGAATT CCGGTCCTAG AGCACCACGG 1920 CAGCCACCAG CCCCCGCCGC GGGACCCCAC CGAGCGGCAG GTGATCCGGG CGGTGGAGGG 1980

GGCGGGGATC GGAGTGGCTG TCCTTGTCGC GGTGGTTCTG GCCGGGACCG CGGTAGTGTA 2040

CCTCACCCAC GCCTCCTCGG TGCGCTATCG TCGGCTGCGG TAACTCCGGG GCCGGGCCCG 2100

GCCGCCGGTT GTCTTCTTTT CCACCCCTTC CGTCCCCCGT ACCCACCACA CCCCACCCCA 2160 CCCCCCCGCC GTCCCCCGGG CGTTATAAGC CGCCGCACTC GCTTTTCCCA CCGGAAAATC 2220

CTCGGCCCGA TCCGAACGGC GCACGCCGCG TGGGCTCCAA ACGCCTCCGG AAGAGAGCGC 2280

CCCGCCCCGA TATTCAAGCC CGCGGTGGTG CTATGGCTTT CCGTGCTTCG GGACCCGCCT 2340

ACCAGCCCCT CGCCCCCGCG GCCTCCCCGG CGCGGGCTCG TGTTCCGGCC GTGGCCTGGA 2400

TCGGCGTCGG AGCGATCGTC GGGGCCTTTG CGCTCGTCGC CGCGTTGGTT CTCGTACCCC 2460 CTCGGTCCTC GTGGGGACTC TCGCCGTGCG ACAGCGGCTG GCAGGAATTC AACGCGGGAT 2520

GCGTCGCGTG GGACCCCACC CCCGTCGAGC ACGAGCAGGC GGTCGGCGGC TGCAGCGCGC 2580

CGGCCACCCT TATCCCCCGT GCGGCCGCCA AGCACCTGGC CGCTCTGACA CGCGTCCAGG 2640

CGGAGAGATC GTCGGGTTAC TGGTGGGTGA ACGGAGACGG CATCCGGACC TGTCTGAGAC 2700

TCGTCGACAG CGTCAGTGGC ATCGACGAGT TTTGCGAGGA GCTCGCGATC CGCATATGCT 2760 ACTACCCACG AAGCCCCGGC GGGTTTGTCC GCTTCGTAAC TTCGATACGT AACGCCCTGG 2820

GGTTGCCGTG AGGCGCGCGT CCGACGGTCC CGCTTCTCGC CTCTCTTCTT CCCCCTCCCC 2880

ACCCCACCCA CCGACCAACG ACGGCGTTTG GCCAATACCC TCCTTTTTTC TTTTTCTCTT 2940

CCCCCCCCAA AAAAAAAAAC AATAAACAGC TAATTGCGTA CGACAAACCA TGCGGAACTC 3000

GCTGTTTTTT TTTCTCTGTT TGTTACTTTT TATTGAAAAC AGACATACGG GGAAAGGGGC 3060 CGGAAACCGA GACGGTGGGG CCGGCGGTCG CATTTTTTTA ATGGCTCTGG TGTCGGCCGC 3120

GTTTGAGCTT CGTCAACAGG GCGCTGAGGG CGGCGACGTT TGTCGGGCCG TCGTTGGCCA 3180

GCGCGTTGGT CCGGGGGCGG GCGGGCATGG GCGACAGGCT TAGTCCCGGG TCCGGGGCGC 3240

GTGTGGCCCC CGGAGGGGAG AAGAGGGCAG ACCCGCCCCA GTCGTACAGG GGATTTTCCG 3300

CCTCGATGTA CGGGGAGTCC GGGGCGTCTC CCGGCGGGGC CGCCCCGCCG GCGTCTTGCC 3360 GGCGAAGGCA GATGTTTTCG TATACCCGAA CCCAGGGGAT CTCCTCGTAG ACGCGCCCCC 3420

CATCCTCGCT CACCGACTCG TAAATGGAAT CTGCGTCCTC GGAGGGGGCG CGGGGGGCGT 3480

GGCTTTCGGC CGGCCAGGCG GCGGCGGTGG TGTCGGCGGC GGGGGTGGCG CCAAGCCCGA 3540

CGCCCGCGGG CATGGCGGCG TCATCGTCGG GCAGCAGATA CGTGTTTTCC ATCTGGTCCG 3600

GTTCGGCCTC CGCGTCTGGC CCCCAGGTCC GCACCGCGTC GTAAACCCCG GCGGCCTCGC 3660 GCTGAGCCGC GAGCGGGCGC GCCGCGGCTG CCGGCCGC 3699

(2) INFORMATION FOR SEQ ID NO: 196:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 117 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 196: Xaa Xaa Xaa Xaa Xaa Gly Gly His Ala Ala Ala Gly Leu Thr Glu Leu

1 5 10 15

Cys Gin Thr Leu Ala Pro Arg, Asp Leu Thr Asp Pro Leu Leu Phe Ala 20 25 30 Tyr Val Gly Phe Gin Val Val Asn His Gly Leu Met Phe Val Val Pro 35 40 45

Asp Ile Ala Val Tyr Ala Met Leu Gly Gly Ala Val Trp Ile Ser Leu

50 55 60

Thr Gin Val Leu Gly Leu Arg Arg Arg Leu His Lys Asp Pro Asp Ala 65 70 75 80

Gly Pro Trp Ala Ala Ala Thr Leu Arg Gly Leu Phe Phe Ser Val Tyr

85 90 95

Ala Leu Gly Phe Ala Ala Gly Val Leu Val Arg Pro Arg Met Ala Ala 100 105 110 Ser Arg Arg Ser Gly 115

(2) INFORMATION FOR SEQ ID NO: 197:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 536 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 197:

Met Gly Ala Gly Val Pro Trp Thr Gly Ile Lys Arg Ala Gly Gly Pro 1 5 10 15

Ile Thr Val Arg Val Leu Gly Trp Glu Val Ala Gin Lys Ala Thr His

20 25 30

Pro Cys Cys Ser Cys Pro Arg Glu Ala Val Val Ser Gly Asn Pro Pro 35 40 45

Arg Cys Ala Gly Arg Ala His Arg Ser Phe Ala Gly Ala Gly Ala Leu

50 55 60

Leu Val Met Ala Leu Gly Arg Val Gly Leu Ala Val Gly Leu Trp Gly 65 70 75 80 Leu Leu Trp Val Gly Val Val Val Val Leu Ala Asn Asp Gly Arg Thr

85 90 95

Ile Thr Val Gly Pro Arg Gly Asn Asn Ala Ala Pro Ser Asp Arg Asn 100 105 110 Ala Ser Ala Pro Arg Thr Thr Pro Thr Pro Pro Gin Pro Arg Lys Ala

115 120 125

Thr Lys Ser Lys Ala Ser Thr-Ala Lys Pro Ala Pro Pro Pro Lys Thr

130 135 140 Gly Pro Pro Lys Thr Ser Ser Glu Pro Val Arg Cys Asn Arg His Asp

145 150 155 160

Pro Leu Ala Arg Tyr Gly Ser Arg Val Gin Ile Arg Cys Arg Phe Pro

165 170 175

Asn Ser Thr Arg Thr Glu Ser Arg Leu Gin Ile Trp Arg Tyr Ala Thr 180 185 190

Ala Thr Asp Ala Glu Ile Gly Thr Ala Pro Ser Leu Glu Glu Val Met

195 200 205

Val Asn Val Ser Ala Pro Pro Gly Gly Gin Leu Val Tyr Asp Ser Ala

210 215 220 Pro Asn Arg Thr Asp Pro His Val Ile Trp Ala Glu Gly Ala Gly Pro

225 230 235 240

Gly Asp Arg Lys Val Val Gly Pro Leu Gly Arg Gin Arg Leu Ile Ile

245 250 255

Glu Glu Leu Thr Leu Glu Thr Gin Gly Met Tyr Tyr Trp Val Trp Gly 260 265 270

Arg Thr Asp Arg Pro Ser Ala Tyr Gly Thr Trp Val Arg Val Arg Val

275 280 285

Phe Arg Pro Pro Ser Leu Thr Ile His Pro His Ala Val Leu Glu Gly

290 295 300 Gin Pro Phe Lys Ala Thr Cys Thr Ala Ala Thr Tyr Tyr Pro Gly Asn

305 310 315 320

Arg Ala Glu Phe Val Trp Phe Glu Asp Gly Arg Arg Val Phe Asp Pro

325 330 335

Ala Gin Ile His Thr Gin Thr Gin Glu Asn Pro Asp Gly Phe Ser Thr 340 345 350

Val Ser Thr Val Thr Ser Ala Ala Val Gly Gly Gin Gly Pro Pro Arg

355 360 365

Thr Phe Thr Cys Gin Leu Thr Trp His Arg Asp Ser Val Ser Phe Ser

370 375 380 Arg Arg Asn Ala Ser Gly Thr Ala Ser Val Leu Pro Arg Pro Thr Ile

385 390 395 400

Thr Met Glu Phe Thr Gly Asp His Ala Val Cys Thr Ala Gly Cys Val

405 410 415

Pro Glu Gly Val Thr Phe Ala Trp Phe Leu Gly Asp Asp Ser Ser Pro 420 425 430

Ala Glu Lys Val Ala Val Ala Ser Gin Thr Ser Cys Gly Arg Pro Gly

435 440 445

Thr Ala Thr Ile Arg Ser Thr Leu Pro Val Ser Tyr Glu Gin Thr Glu 450 455 460

Tyr Ile Cys Arg Leu Ala Gly Tyr Pro Asp Gly Ile Pro Val Leu Glu 465 470 , 475 480

His His Gly Ser His Gin Pro Pro Pro Arg Asp Pro Thr Glu Arg Gin 485 490 495

Val lie Arg Ala Val Glu Gly Ala Gly Ile Gly Val Ala Val Leu Val

500 505 510

Ala Val Val Leu Ala Gly Thr Ala Val Val Tyr Leu Thr His Ala Ser 515 520 525 Ser Val Arg Tyr Arg Arg Leu Arg 530 535

(2) INFORMATION FOR SEQ ID NO: 198:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 189 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 198:

Val Gly Ser Lys Arg Leu Arg Lys Arg Ala Pro Arg Pro Asp Ile Gin 1 5 10 15

Arg Gly Ala Met Ala Phe Arg Ala Ser Gly Pro Ala Tyr Gin Pro Leu

20 25 30

Ala Pro Ala Asp Ala Arg Ala Arg Val Pro Ala Val Ala Trp Ile Gly 35 40 45

Val Gly Ala Ile Val Gly Ala Phe Ala Leu Val Ala Ala Leu Val Leu

50 55 60

Val Pro Pro Arg Ser Ser Trp Gly Leu Ser Pro Cys Asp Ser Gly Trp 65 70 75 80 Gin Glu Phe Asn Ala Gly Cys Val Ala Trp Asp Pro Thr Pro Val Glu

85 90 95

His Glu Gin Ala Val Gly Gly Cys Ser Ala Pro Ala Thr Leu Ile Pro

100 105 110

Arg Ala Ala Ala Lys His Leu Ala Ala Leu Thr Arg Val Gin Ala Glu 115 120 125

Arg Ser Ser Gly Tyr Trp Trp Val Asn Gly Asp Gly Ile Arg Thr Cys

130 135 140

Leu Arg Leu Val Asp Ser Val Ser Gly Ile Asp Glu Phe Cys Glu Glu 145 150 155 160

Leu Ala Ile Arg Ile Cys Tyr Tyr Pro Arg Ser Pro Gly Gly Phe Val

165 - 170 175

Arg Phe Val Thr Ser Ile Arg Asn Ala Leu Gly Leu Pro 180 185

(2) INFORMATION FOR SEQ ID NO: 199:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 198 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 199:

Gin Arg Pro Ala Ala Ala Ala Arg Pro Leu Ala Ala Gin Arg Glu Ala 1 5 10 15

Ala Gly Val Tyr Asp Ala Val Arg Thr Trp Gly Pro Asp Ala Glu Ala

20 25 30

Glu Pro Asp Gin Met Glu Asn Thr Tyr Leu Leu Pro Asp Asp Asp Ala 35 40 45 Ala Met Pro Ala Gly Val Gly Leu Gly Ala Thr Pro Ala Ala Asp Thr 50 55 60

Thr Ala Ala Ala Trp Pro Ala Glu Ser His Ala Pro Arg Ala Pro Ser 65 70 75 80

Glu Asp Ala Asp Ser Ile Tyr Glu Ser Val Ser Glu Asp Gly Gly Arg 85 90 95

Val Tyr Glu Glu Ile Pro Trp Val Arg Val Tyr Glu Asn Ile Cys Leu

100 105 110

Arg Arg Gin Asp Ala Gly Gly Ala Ala Pro Pro Gly Asp Ala Pro Asp 115 120 125 Ser Pro Tyr Ile Glu Ala Glu Asn Pro Leu Tyr Asp Trp Gly Gly Ser 130 135 140

Ala Leu Phe Ser Pro Pro Gly Ala Thr Arg Ala Pro Asp Pro Gly Leu 145 150 155 160

Ser Leu Ser Pro Met Pro Ala Arg Pro Arg Thr Asn Ala Asn Asp Gly 165 170 175

Pro Thr Asn Val Ala Ala Leu Ser Ala Leu Leu Thr Lys Leu Lys Arg

180 185 190

Gly Arg His Gin Ser His 195

(2) INFORMATION FOR SEQ ID NO: 200:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 152 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 200:

CTGTGTGAAA TTGTTATCCG CTCACAATTC CACACAACAT ACGAGCCGGA AGCATAAAGT 60 GTAAAGCCTG GGGTGCCTAA TGAGTGAGCT AACTCACATT AATTGCGTTG CGCTCACTGC 120

CCGCTTTCCA GTCGGGAAAC CTGTCGTGCC A 152

(2) INFORMATION FOR SEQ ID NO: 201:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 129 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 201:

CCCGGAGCCC GGCGGCCGCA GCCGAGCAGC GCCGCGGGCT CCGGGGCCGG GCCGGGCCGG 60 CAACGCCCCG CGCCGGCCGC GGCGGTGAGA ACCCCTGTGT CATTGTTTAC GTGGCCGCGG 120

GCCAGCAG 129

(2) INFORMATION FOR SEQ ID NO: 202:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 127 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 202: GGTGGGGCGC GGCGGCCGGC TCGGGGTGGG GGGAGAGTGT CGTGGGTGTG TTTTCGTGTC 60 CCCCACCACC ACTCCCACCC CGACCGCCGC CGCGCCCGCG TTTCTGCCGC CCGCGCGCTC 120 CTGTGT - 127

(2) INFORMATION FOR SEQ ID NO: 203:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 157 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:203:

ATGCACGTGT AACCGCCAGT CCGTGCTTGC CTAGCGAACT CACCCGTCCC GGCTGGCGTG 60 CGCAGCCCGG GCCGTGTTGC GGGCCCTCTT AAGGGGCGGC GGCAGGACGG GGACTCCGCC 120 CCGCCTCCTT TCCCCCGGGG AGTCAACCCC CGGGGG 157

(2) INFORMATION FOR SEQ ID NO: 204:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16813 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 204:

GGGGGGACGG GACGGGGGGA CGGGACGGGG GGGCCCCGAT CCCAACATCC GCGCTTTCTC 60

GCAGGCCGGG CGCCGCCTTC GTGGACGGGA CACCGGTGTG GTAACTGGCG ACAAGGCGTC 120

GCCACTATGG CAGACATCCC CCCGGACCCG CCCGCGCTCA ACACGACGCC TGCGAATCAT 180

GCTCCCCCAT CCCCACCCCC GGGTTCACGG AAGCGCAGAC GCCCCGTCCT CCCCAGCTCG 240 TCGGAATCTG AGGGTAAGCC CGACACAGAA TCGGAATCCT CCTCGACCGA GTCGTCCGAG 300

GATGAGGCGG GAGACCTACG CGGCGGGCGC CGTCGCTCCC CGCGGGAGCT CGGGGGGAGG 360

TATTTTTTGG ATCTGTCGGC AGAATCGACC ACGGGGACGG AATCGGAGGG AACGGGGCCG 420

TCGGACGACG ATGATGATGA TGCGTCAGAC GGCTGGTTGG TTGACACCCC CCCCCGTAAA 480

TCCAAGCGAC CCCGAATCAA CCTGCGATTA ACGAGCTCCC CCGACCGGCG CGCGGGTGTG 540 GTTTTCCCCG AGGTGTGGAG AAACGACAGA CCTATCCGCG CGGCGCAACC CCAGGCCCCG 600

GCCCAGTCTT CCGGGGATCG CGCAGCCGCA CCGCGGCGCT CTGCTCGCCA GGCCCAGATG 660

CGGAGCGGAG CCGCCTGGAC GCTTGATCTG CATTACATAC GCCAGTGCGT CAACCAGCTC 720

TTTCGGATCC TGCGTGCCGC CCCGAACCCG CCCGGCAGCG CCAACCGCCT GCGCCACCTG 780 GTGCGAGACT GCTACCTTAT GGGCTACTGC CGGACCCGCC TGGGGCCGCG CACGTGGGGC 840

CGCCTGCTGC AGATCTCGGG CGGAACCTGG GACGTGCGCC TGCGAAACGC AATCCGGGAG 900

GTCGAGGCGC GTTTTGAACC CGCCGCCGAG CCCGTGTGCG AGCTGCCCTG TCTGAACGCC 960

AGGCGTTACG GCCCCGAGTG TGATGTTGGC AATCTCGAGA CCAACGGCGG CTCGACGAGC 1020 GATGATGAGA TATCGGATGC GACGGACTCG GACGATACCC TCGCGTCCCA TTCCGACACG 1080

GAGGCGGGGC CCTCCCCGGC CGGCCGGGAG AACCCGGAAT CCGCGTCCGG CGGGGCTATC 1140

GCGGCTCGGC TGGAGTGTGA GTTTGGGACG TTTGACTGGA CGTCCGAGGA GGGCTCCCAG 1200

CCCTGGCTGT CCGCGGTGGT CGCCGATACC AGCTCCGCCG AACGCTCTGG CCTACCCGCC 1260

CCGGGCGCGT GTCGCGCAAC GGAAGCCCCA GAACGCGAGG ACGGGTGCCG AAAAATGCGC 1320 TTCCCCGCCG CCTGCCCCTA TCCCTGCGGC CACACATTTC TCCGGCCATG AGCGCGGGAC 1380

CCCCAGCCCG GTGTGTTTGC CAAACGAAAA TAAACGCCCT ACAAGAAAGC TTTTGTGTCT 1440

GAGTGTCTGG TTTTTCTGGG GGTGGAGGAA GGAACGACAA AAAAAGAAAC AAACGCGACA 1500

CCGCTCGTAC GTGTAATGGG GCGCAGTGTT TTTTATTAGC ATCGGGGGGG GGTTAGAGGT 1560

TGGTGATTGG ATAGCAAACG TGGGATGACG GAGGCCACTC GTCGCCAACG GCCAGCGGGG 1620 GCCCGGGGTT CTGGGGGTCA TCGTCCCCCG TCTGCCAGGA GGGCTCATCG GGAATCTCGG 1680

GTCGCCCCAT GCACGTAAAA CACGGGCGCT GCGTGGGGTG GGTCGCCGGA TGCGGGCGGG 1740

ATGATGCGGG GCGGGGTTTG TTGTGAGGAG CCACGAGGGA CCGTAGCCAG CGAAGACAGC 1800

TGCGTTCCCG GTCGCCGGGC ACCACCACGC CGTATTGGTA TTCGTATCGG CTAAGGAGAT 1860

TTTCCAGGGG GTGATTAGGC GCTGCGGGGA ACGGGGTCCA CGACACGGTC CGCTCGGGCA 1920 AAAACCGATC GGGCAGGGGC CACGGTTCCC CCACCCACGC GTCGTTGGTC TTCATGGCGA 1980

TGAAGCGAAA CCCCAGCCGG GTTTTTTGTG CGTACTCTAA AAACGGCACA CACAGGTCCG 2040

CCGCCCCGAC CACCCACAGG TGGTATAGCC GGTGGGGGCC GGGGCGCTCT TGATGCAGGA 2100

GCCGAAAACA CGCAGGGGCA TCCAGAATCT CGATGCTTTC CAGGGGGTCG TCCTCCGCAA 2160

ACAGGCCCGT CGTGGTGTTT GGGGGACAGC GACAGGAGCG GGTTCGCACG ATCGGTCGGG 2220 TGAATTTGGG CAAGTCCATC AGAGGCTCGG CCAGCCTGCG AAGGTTCGCC GGGCGAACCA 2280

CCACCGGGGT TCCCAGAGGC TCGGAGGCCA GGATCCGGCA TTGCCGAAGC AGAAAACTCC 2340

ACAGAGCCGG GCTTGCGTCA GCGGAAGTCC GCGGCAGGGC GTTTCGTTGG TCTAGGAGGG 2400

TAACCACACT TACAACAACA ACGCCCATGT CGGTATATTA GGCCCGTGGT CCGATCTTCA 2460

CTCACTCGCC TGTCTGCGGA CCTATGCACG GCGGGACGGC GCGCGGACCC GGGGGGGCTG 2520 CTTGCTATCA CACGGCCCGT TCGCACGTTC GATTTTTTCA GCCTTGTTTG GTTGGCTAGG 2580

TATCCCGGAT AATCTGACGT TCCGGATATA GGGGGCGGGG GTAGTGGGGG GGTGTGTCGA 2640

CAAACTGCCG CTTCTTAAAA CACCGGGGCC CGTCGCTCGG GGTGCTCGTT GGTTGGCACG 2700

CGCGACGCGG CGAATGGCCT GTCGTAAGTT CTGTGGGGTC TACCGTAGAC CCGACAAGAG 2760

ACAGGAGGCG TCCGTCCCGC CGGAGACAAA CACGGCCCCG GCCTTCCCGG CGAGCACCTT 2820 TTATACCCCC GCGGAGGATG CGTACCTGGC CCCCGGGCCC CCGGAAACCA TCCACCCTTC 2880

CCGCCCACCG TCCCCCGGCG AGGCTGCGCG CCTGTGTCAG CTGCAGGAGA TCTTGGCCCA 2940

GATGCACAGC GACGAGGACT ACCCCATCGT GGACGCCGCG GGTGCGGAGG AGGAAGACGA 3000

GGCCGACGAT GACGCCCCGG ATGACGTGGC CTACCCGGAG GACTACGCGG AGGGGCGTTT 3060

TCTGTCCATG GTTTCGGCCG CCCCCCTGCC CGGAGCCAGC GGCCATCCTC CTGTTCCGGG 3120 CCGCGCAGCC CCCCCCGACG TCCGGACCTG CGACAGCGGT AAGGTGGGGG CCACGGGGTT 3180

CACCCCGGAA GAGCTCGACA CCATGGACCG GGAGGCACTT CGGGCCATCA GCCGCGGGTG 3240

CAAGCCCCCT TCGACCCTGG CAAAACTGGT GACCGGGCTG GGATTCGCGA TCCACGGAGC 3300

GCTCATCCCG GGGTCGGAGG GGTGTGTCTT TGATAGCAGC CACCCGAACT ACCCTCATCG 3360 GGTAATCGTC AAGGCGGGGT GGTACGCCAG CACGAACCAC GAGGCGCGGC TGCTGAGACG 3420

CCTGAACCAC CCCGCGATCC TACCCCTCCT GGACCTGCAC GTCGTTTCTG GGGTCACGTG 3480

TCTGGTCCTC CCCAAGTATC ACTGCGACCT GTATACCTAT CTGAGCAAGC GCCCGTCTCC 3540

GTTGGGCCAC CTACAGATAA CCGCGGTCTC CCGGCAGCTC TTGAGCGCCA TCGACTACGT 3600 CCACTGCGAA GGCATCATCC ACCGCGATAT TAAGACCGAG AACATCCTCA TCAACACCCC 3660

CGAGAACATC TGTCTGGGGG ACTTTGGGGC GGCGTGCTTT GTGCGCGGGT GTCGATCGAG 3720

CCCCTTCCAT TACGGGATCG CAGGCACCAT CGATACAAAC GCCCCCGAGG TCCTGGCCGG 3780

GGATCCGTAC ACCCAGGTAA TCGACATCTG GAGCGCCGGC CTGGTGATCT TTGAGACCGC 3840

CGTCCACACC GCGTCCTTGT TCTCGGCCCC GCGCGACCCC GAAAGGCGGC CGTGCGACAA 3900 CCAGATCGCG CGCATCATCC GACAGGCCCA GGTACACGTC GACGAGTTTC CAACGCACGC 3960

GGAATCGCGC CTCACCGCGC ACTACCGCTC GCGGGCGGCC GGGAACAATC GTCCGGCGTG 4020

GACCCGACCG GCATGGACCC GCTACTACAA GATCCACACA GACGTCGAAT ATCTCATCTG 4080

CAAAGCCCTT ACCTTTGACG CGGCGCTCCG CCCAAGCGCC GCGGAGTTGC TGCGCCTGCC 4140

GCTATTTCAC CCTAAGTGAC CCCGCTCCCC CCGGGGGGCG TGGAGGGGGG GCTGGTTGGA 4200 TGTTTTTGCA CAAAAAGACG CGGCCCTCGG GCTTTGGTGT TTTTGGCACC TTGCCGCCCG 4260

GCGTCATGCA CGCCATCGCT CCCAGGTTGC TTCTTCTTTT TGTTCTTTCT GGTCTTCCGG 4320

GGACACGCGG CGGGTCGGGT GTCCCCGGAC CAATTAATCC CCCCAACAAC GATGTTGTTT 4380

TCCCGGGAGG TTCCCCCGTG GCTCAATATT GTTATGCCTA TCCCCGGTTG GACGATCCCG 4440

GGCCCTTGGG TTCCGCGGAC GCCGGGCGGC AAGACCTGCC CCGGCGCGTC GTCCGTCACG 4500 AGCCCCTGGG CCGCTCGTTC CTCACGGGGG GGCTGGTTTT GCTGGCGCCG CCGGTACGCG 4560

GATTTGGCGC ACCCAACGCA ACGTATGCGG CCCGTGTGAC GTACTACCGG CTCACCCGCG 4620

CCTGCCGTCA GCCCATCCTC CTTCGGCAGT ATGGAGGGTG TCGCGGCGGC GAGCCGCCGT 4680

CCCCAAAGAC GTGCGGGTCG TACACGTACA CGTACCAGGG CGGCGGGCCT CCGACCCGGT 4740

ACGCTCTCGT AAATGCTTCC CTGCTGGTGC CGATCTGGGA CCGCGCCGCG GAGACATTCG 4800 AGTACCAGAT CGAACTCGGC GGCGAGCTGC ACGTGGGTCT GTTGTGGGTA GAGGTGGGCG 4860

GGGAGGGCCC CGGCCCCACC GCCCCCCCAC AGGCGGCGCG TGCGGAGGGC GGCCCGTGCG 4920

TCCCCCCGGT CCCCGCGGGC CGCCCGTGGC GCTCGGTGCC CCCGGTATGG TATTCCGCCC 4980

CCAACCCCGG GTTTCGTGGC CTGCGTTTCC GGGAGCGCTG TCTGCCCCCA CAGACGCCCG 5040

CCGCCCCCAG CGACCTACCA CGCGTCGCTT TTGCTCCCCA GAGCCTGCTG GTGGGGATTA 5100 CGGGCCGCAC GTTTATTCGG ATGGCACGAC CCACGGAAGA CGTCGGGGTC CTGCCACCCC 5160

ATTGGGCCCC CGGGGCCCTA GATGACGGTC CGTACGCCCC CTTCCCACCC CGCCCGCGGT 5220

TTCGACGCGC CCTGCGGACA GACCCCGAGG GGGTCGACCC CGACGTTCGG GCCCCCCTAA 5280

CCGGGCGGCG CCTCATGGCC TTGACCGAGG ACGCGTCCTC CGATTCGCCT ACGTCCGCTC 5340

CGGAGAAGAC GCCCCTCCCT GTGTCGGCCA CCGCCATGGC GCCCTCAGTC GACCCAAGCG 5400 CGGAACCGAC CGCCCCCGCA ACCACTACTC CCCCCGACGA GATGGCCACA CAAGCCGCAA 5460

CGGTCGCCGT TACGCCGGAG GAAACGGCAG TCGCCTCCCC GCCCGCGACT GCATCCGTGG 5520

AGTCGTCGCC ACTCCCCGCC GCGGCGGCAA CGCCCGGGGC CGGGCACACG AACACCAGCA 5580

GCGCCCCCGC AGCGAAAACG CCCCCCACCA CACCAGCCCC CACGACCCCC CCGCCCACGT 5640

CTACCCACGC GACCCCCCGC CCCACGAGTC CGGGGCCCCA AACAACCCCT CCCGGACCCG 5700 CAACCCCGGG TCCGGTGGGC GCCTCCGCCG CACCCACGGC CGATTCCCCC CTCACCGCCT 5760

CGCCCCCCGC TACCGCGCCG GGGCCCTCGG CCGCCAACGT TTCGGTCGCC GCGACCACCG 5820

CCACGCCCGG AACCCGGGGC ACCGCCCGTA CCCCCCCAAC GGACCCAAAG ACGCACCCAC 5880

ACGGACCCGC GGACGCTCCC CCCGGCTCGC CAGCCCCCCC ACCCCCCGAA CATCGCGGCG 5940 GACCCGAGGA GTTTGAGGGC GCCGGGGACG GCGAACCCCC CGATGACGAC GACAGCGCCA 6000

CCGGCCTCGC CTTCCGAACT CCGAACCCCA ACAAACCACC CCCCGCGCGC CCCGGGCCCA 6060

TCCGCCCCAC GCTCCCGCCA GGAAT-TCTTG GGCCGCTCGC CCCCAACACG CCTCGCCCCC 6120

CCGCCCAAGC TCCCGCTAAG GACATGCCCT CGGGCCCCAC ACCCCAACAC ATCCCCCTGT 6180 TCTGGTTCCT AACGGCCTCC CCTGCTCTAG ATATCCTCTT TATCATCAGC ACCACCATCC 6240

ACACGGCGGC GTTCGTTTGT CTGGTCGCCT TGGCAGCACA ACTTTGGCGC GGCCGGGCGG 6300

GGCGCAGGCG ATACGCGCAC CCGAGCGTGC GTTACG ATG TCTGCCACCC GAGCGGGATT 6360

AGGGGGTGGG GTGGGGGCGA GAAACGATGA AGGACGGGAA AGGGAACAGC GACCAAATGC 6420

CACGATAAGA ACAATAAACC TGTGACGTCA ATCGGATATG TGAGTTTGGT TGTGTTTTGT 6480 GGGACTGGGG GCGGGGGGTG GGAGGTATCA GTGGGTGACA GAGTCTTTTA AAAGACGTGT 6540

CCCGGGGCCC TCGAGACGCG CAACTTTTGG CCACACAGAG AAAGGCCCCC AGACGAAGTC 6600

ACCCGGGTCC CCGAACAAAA ACAAAAACCT TGACCGCCGC CGGGGGGCGT GCCTGTTGTT 6660

TTGGTCTCAA TGGATCGGTA TGCCGTTCGG ACCTGGGGGA TTGTGGGAAT CCTCGGGTGT 6720

GCTGCTGTTG GGGCCGCACC CACCGGCCCC GCGTCCGATA CAACAAACGC GACCGCACGC 6780 CTCCCCACGC ACCCCCCACT CATCCGTTCC GGGGGCTTTG CCGTCCCCCT CATCGTGGGG 6840

GGGCTGTGTC TCATGATTCT GGGGATGGCG TGTCTACTCG AGGTCCTGCG TCGCCTGGGT 6900

CGCGAGTTGG CGAGGTGCTG CCCCCACGCG GGCCAATTTG CCCCATGATT TTTCGCCTTT 6960

CTGGCCTTGC CCCCACCCCA TCGCCCCGAT TGTGTGTCGG GTGCCCGGGG TACAGCAGCT 7020

ATGGAGCGGT CGGTAATATA ACTTTGGTTG TCGCCACACG CCCCGTGCCG GGCATGGGTT 7080 GTGCGGGAAA GACGAAATAA TCCGGCGATC CCCAAGCGTA CCAACTTGGG GGGGGGGGGA 7140

AAGAAACTAA AAACACATCA AGCCCACAAC CCATCCCACA AGGGGGGTTA TGGCGGACCC 7200

ACCGCACCAC CATACTCCGA TTCGACCACA TATGCAACCA AATCACCCCC AGAGGGGAGG 7260

TTCCATTTTT ACGAGGAGGA GGAGTATAAT AGAGTCTTTG TGTTTAAAAC CCGGGGTCGG 7320

TGTGGTGTTC GGTCATAAGC TGCATTGCGA ACGACTAGTC GCCGTTTTTC GTGTGCATCG 7380 CGTATCACGG CATGGGGCGT TTGACCTCCG GCGTCGGGAC GGCGGCCCTG CTAGTTGTCG 7440

CGGTGGGACT CCGCGTCGTC TGCGCCAAAT ACGCCTTAGC AGACCCCTCG CTTAAGATGG 7500

CCGATCCCAA TCGATTTCGC GGGAAGAACC TTCCGGTTTT GGACCAGCTG ACCGACCCCC 7560

CCGGGGTGAA GCGTGTTTAC CACATTCAGC CGAGCCTGGA GGACCCGTTC CAGCCCCCCA 7620

GCATCCCGAT CACTGTGTAC TACGCAGTGC TGGAACGTGC CTGCCGCAGC GTGCTCCTAC 7680 ATGCCCCATC GGAGGCCCCC CAGATCGTGC GCGGGGCTTC GGACGAGGCC CGAAAGCACA 7740

CCTACAACCT GACCATCGCC TGGTATCGCA TGGGAGACAA TTGCGCTATC CCCATCACGG 7800

TTATGGAATA CACCGAGTGC CCCTACAACA AGTCGTTGGG GGTCTGCCCC ATCCGAACGC 7860

AGCCCCGCTG GAGCTACTAT GACAGCTTTA GCGCCGTCAG CGAGGATAAC CTGGGATTCC 7920

TGATGCACGC CCCCGCCTTC GAGACCGCGG GTACGTACCT GCGGCTAGTG AAGATAAACG 7980 ACTGGACGGA GATCACACAA TTTATCCTGG AGCACCGGGC CCGCGCCTCC TGCAAGTACG 8040

CTCTCCCCCT GCGCATCCCC CCGGCAGCGT GCCTCACCTC GAAGGCCTAC CAACAGGGCG 8100

TGACGGTCGA CAGCATCGGG ATGCTCCCCC GCTTTATCCC CGAAAACCAG CGCACCGTCG 8160

CCCTATACAG CTTAAAAATC GCCGGGTGGC ACGGCCCCAA GCCCCCGTAC ACCAGCACCC 8220

TGCTGCCGCC GGAGCTGTCC GACACCACCA ACGCCACGCA ACCCGAACTC GTTCCGGAAG 8280 ACCCCGAGGA CTCGGCCCTC TTAGAGGATC CCGCCGGGAC GGTGTCTTCG CAGATCCCCC 8340

CAAACTGGCA CATCCCGTCG ATCCAGGACG TCGCGCCGCA CCACGCCCCC GCCGCCCCCA 8400

GCAACCCGGG CCTGATCATC GGCGCGCTGG CCGGCAGTAC CCTGGCGGTG CTGGTCATCG 8460

GCGGTATTGC GTTTTGGGTA CGCCGCCGCG CTCAGATGGC CCCCAAGCGC CTACGTCTCC 8520 CCCACATCCG GGATGACGAC GCGCCCCCCT CGCACCAGCC ATTGTTTTAC TAGAGGAGTA 8580

TCCCCGCTCC CGTGTACCTC TGGGCCCGTG TGGGAGGGTG GCTGGGGTAT TTGGGTGGGA 8640

CTTGGACTCC GCATAAAGGG AGTCTCGAAG GAGGGAAACT AGGACAGTTC ATAGGCCGGG 8700

AGCGTGGGGC GCGCACCGCT GTCCCGACGA TTAGCCACCG CGCCCACAGT CACCTCGACC 8760 CGTCCGATCC CGGTATGCCC GGCCGCTCGC TGCAGGGCCT GGCGATCCTG GGCCTGTGGG 8820

TCTGCGCCAC CGGCCTGGTC GTCCGCGGCC CCACGGTCAG TCTGGTCTCA GACTCACTCG 8880

TGGATGCCGG GGCCGTGGGG CCCCAGGGCT TCGTGGAAGA GGACCTGCGT GTTTTCGGGG 8940

AGCTTCATTT TGTGGGGGCC CAGGTCCCCC ACACAAACTA CTACGACGGC ATCATCGAGC 9000

TGTTTCACTA CCCCCTGGGG AACCACTGCC CCCGCGTTGT ACACGTGGTC ACACTGACCG 9060 CATGCCCCCG CCGCCCCGCC GTGGCGTTCA CCTTGTGTCG CTCGACGCAC CACGCCCACA 9120

GCCCCGCCTA TCCGACCCTG GAGCTGGGTC TGGCGCGGCA GCCGCTTCTG CGGGTTCGAA 9180

CGGCAACGCG CGACTATGCC GGTCTGTATG TCCTGCGCGT ATGGGTCGGC AGCGCGACGA 9240

ACGCCAGCCT GTTTGTTTTG GGGGTGGCGC TCTCTGCCAA CGGGACGTTT GTGTATAACG 9300

GCTCGGACTA CGGCTCCTGC GATCCGGCGC AGCTTCCCTT TTCGGCCCCG CGCCTGGGAC 9360 CCTCGAGCGT ATACACCCCC GGAGCCTCCC GGCCCACCCC TCCACGGACA ACGACATCCC 9420

CGTCCTCCCC CCGAGACCCG ACCCCCGCCC CCGGGGACAC AGGGACGCCC GCGCCCGCGA 9480

GCGGCGAGAG AGCCCCGCCC AATTCCACGC GATCGGCCAG CGAATCGAGA CACAGGCTAA 9540

CCGTAGCCCA GGTAATCCAG ATCGCCATAC CGGCGTCCAT CATCGCCTTT GTGTTTCTGG 9600

GCAGCTGTAT CTGCTTCATC CATAGATGCC AGCGCCGATA CAGGCGCCCC CGCGGCCAGA 9660 TTTACAACCC CGGGGGCGTT TCCTGCGCGG TCAACGAGGC GGCCATGGCC CGCCTCGGAG 9720

CCGAGCTGCG ATCCCACCCA AACACCCCCC CCAAACCCCG ACGCCGTTCG TCGTCGTCCA 9780

CGACCATGCC TTCCCTAACG TCGATAGCTG AGGAATCGGA GCCAGGTCCA GTCGTGCTGC 9840

TGTCCGTCAG TCCTCGGCCC CGCAGTGGCC CGACGGCCCC CCAAGAGGTC TAGGTCCAAG 9900

CGGGCCGTTC GGCAGGCCCG CCCCACCGCC CCCATCGTGG TTATTTCCCC CCCAATAAAC 9960 CGATGTTATT TGCCTATATG CGTGTGTTGG ATCCCTTTGT GATCGTTCGT CATTCCCCGG 10020

ATGGCATGGG AGGCGGGTAA TGGATGGGCG GGGCCCGGGG GGGGAGGAAA AAGAATAAAG 10080

GGGGTAGTGT CGGAGAGGCC CGCCGCGCAT TTAAGGAGTC GCCGCCCCGA CTCTGTGTCT 10140

TCGGGTGACT TGGTGCGCCG CCGTCAGCTA GTCTCCGATC TGCCCCGACC GACGGCTCCT 10200

GCCACCCGAA CATGGCTCGC GGGGCCGGGT TGGTGTTTTT TGTTGGAGTT TGGGTCGTAT 10260 CGTGCCTGGC GGCAGCACCC AGAACGTCCT GGAAACGGGT AACCTCGGGC GAGGACGTGG 10320

TGTTGCTTCC GGCGCCCGCG GGGCCGGAGG AACGCACCCG GGCCCACAAA CTACTGTGGG 10380

CCGCGGAACC CCTGGATGCC TGCGGTCCCC TGCGCCCGTC GTGGGTGGCG CTGTGGCCCC 10440

CCCGACGGGT GCTCGAGACG GTCGTGGATG CGGCGTGCAT GCGCGCCCCG GAACCGCTCG 10500

CCATAGCATA CAGTCCCCCG TTCCCCGCGG GCGACGAGGG ACTGTATTCG GAGTTGGCGT 10560 GGCGCGATCG CGTAGCCGTG GTCAACGAGA GTCTGGTCAT CTACGGGGCC CTGGAGACGG 10620

ACAGCGGTCT GTACACCCTG TCCGTGGTCG GCCTAAGCGA CGAGGCGCGC CAAGTGGCGT 10680

CGGTGGTTCT GGTCGTGGAG CCCGCCCCTG TGCCGACCCC GACCCCCGAC GACTACGACG 10740

AAGAAGACGA CGCGGGCGTG AGCGAACGCA CGCCGGTCAG CGTTCCCCCC CCAACCCCCC 10800

CCCGTGGTCC CCCCGTGGCC CCCCCGACGC ACCCTCGTGT TATCCCCGAG GTGTCCCACG 10860 TGCGCGGGGT AACGGTCCAT ATGGAGACCC CGGAGGCCAT TCTGTTTGCC CCCGGGGAGA 10920

CGTTTGGGAC GAACGTCTCC ATCCACGCCA TTGCCCACGA CGACGGTCCG TACGCCATGG 10980

ACGTCGTCTG GATGCGGTTT GACGTGCCGT CCTCGTGCGC CGAGATGCGG ATCTACGAAG 11040

CTTGTCTGTA TCACCCGCAG CTTCCAGAGT GTCTATCTCC GGCCGACGCG CCGTGCGCCG 11100 TAAGTTCCTG GGCGTACCGC CTGGCGGTCC GCAGCTACGC CGGCTGTTCC AGGACTACGC 11160

CCCCGCCGCG ATGTTTTGCC GAGGCTCGCA TGGAACCGGT CCCGGGGTTG GCGTGGCTGG 11220

CCTCCACCGT CAATCTGGAA TTCCAGCACG CCTCCCCCCA GCACGCCGGC CTCTACCTGT 11280

GCGTGGTGTA CGTGGACGAT CATATCCACG CCTGGGGCCA CATGACCATC AGCACCGCGG 11340 CGCAGTACCG GAACGCGGTG GTGGAACAGC ACCTCCCCCA GCGCCAGCCC GAGCCCGTCG 11400

AGCCCACCCG CCCGCACGTG AGAGCCCCCC CTCCCGCGCC CTCCGCGCGC GGCCCGCTGC 11460

GCCTCGGGGC GGTGCTGGGG GCGGCCCTGT TGCTGGCCGC CCTCGGGCTG TCCGCGTGGG 11520

CGTGCATGAC CTGCTGGCGC AGGCGCTCCT GGCGGGCGGT TAAAAGCCGG GCCTCGGCGA 11580

CGGGCCCCAC TTACATTCGC GTGGCGGACA GCGAGCTGTA CGCGGACTGG AGTTCGGACA 11640 GCGAGGGGGA GCGCGACGGG TCCCTGTGGC AGGACCCTCC GGAGAGACCC GACTCTCCCT 11700

CCACAAATGG ATCCGGCTTT GAGATCTTAT CACCAACGGC TCCGTCTGTA TACCCCCATA 11760

GCGAGGGGCG TAAATCTCGC CGCCCGCTCA CCACCTTTGG TTCGGGAAGC CCGGGCCGTC 11820

GTCACTCCCA GGCCTCCTAT TCGTCCGTCC TCTGGTAAGG CGTCTTCCGA CGACGCGGAC 11880

GTCGGCGATG AACTGATTGC CATCGCGGAC GCACGCGGGG ACCCGCCAGA GACCCTGCCC 11940 CCCGGCGCGG GCGGCGCCGC GCCCGCGTGC CGCAGACCAC CTCGCGGCGG CTCCCCCGCG 12000

GCCTTTCCCG TGGCCCTCCA CGCCGTGGAC GCCCCCTCCC AATTCGTCAC CTGGCTCGCC 12060

GTGCGCTGGC TGCGGGGGGC GGTGGGTCTC GGGGCCGTCC TGTGCGGGAT TGCGTTTTAC 12120

GTGACGTCAA TCGCCCGAGG CGCATAAAGG TCCGGCGGCC AGCCCCGCCG CAGCTCATAA 12180

AAATCGTGAG TCACGGCAAC CGCACCTTCG CCTCCGGCCC TCCGCCAGCG CCCTTCCGCG 12240 TCCGCGATGA CCTCCCGGCC CGCCGACCAA GACTCGGTGC GTTCCAGCGC GTCGGTGCCG 12300

CTTTACCCCG CGGCCTCGCC CGTCCCGGCA GAAGCCTACT ACTCGGAAAG CGAAGACGAG 12360

GCCGCCAACG ACTTCCTCGT GCGCATGGGC CGCCAGCAGT CGGTCCTAAG GCGCCGACGG 12420

CGGCGCACGC GGTGCGTCGG GCTGGTTATC GCCTGTCTCG TCGTGGCCCT CCTATCTGGA 12480

GGGTTCGGGG CACTTTTGGT GTGGCTGCTC CGCTAAATGA CGCCTCGATG TATGGCGCCT 12540 TCTTCGCCCC CACCCCTCGC CGCGACCCAC GTCCGTATGT TAATTGCAAT AAAGTGGTTG 12600

ATTGTCATTA CGGTCTACTA GGTTGTCTTT TTTTTTTGGG GGGGGGGGGA AGGAAATGCA 12660

GAAAAGGGTA AGAAATTCTC GGAATTTCAC CCCCCGGGGG GGGCAAGTGC AGTACCCCAG 12720

TTCCTCAGTG TTTGGGAAAT CTATTGAACT CTCCCGGCTC CTCCGTGTTA GGGAAGTCTC 12780

TTGGGGAAAT CTATTGACCT CTCGCCCCCC CCCCCAGGAG GGGGCAGTGC AGTACCCCAG 12840 TTCCTCCGTG CTGGGGAAAT CTCTCTGCCG GGTACGGGCT CCAGACGAAG GACCCATACA 12900

TTTCCCCATC CGCACCCCAC ATCTGGCGTT CTAGAGTCAC GACGCATTTG CCCCCGTCCC 12960

CGCAGCAACA CACAAAGCGA TTTCAATTTT CACGATTTTA TTATTAATTA CACCAACCAC 13020

CCTGTCCCCG GGACGTGGTC AGGACCGGGG GTCCGCACCC AAACGCACGA AACAAATGCT 13080

GGCAGTGTGC CGAATATAAC CCCGCGTAGG AACACGTCGA CGCGTGCGCC AAACAGCACC 13140 AGAAGGCGCA TGCCATCAGC AGGTCGTGCA TATGGCGATG TGTTTGGACG CAGGGCGCAG 13200

CCGCGGCGAT AAAATTCATG GCGGCCGTCC GCCAGGGCCA CAGCGGCGAG GACTCCCTGT 13260

TGGCCCGAAG CCATTGGGTA TGAACCAGCT GCGCCTCCTG TCCGACCCTG GCTCCCGCCA 13320

GCGGGGGCGG TGGGTCGTGG GTGTTGAGAG CACACAGGCG GGACACCTCG ATCACCGTCC 13380

GAAAAAAGGC CCGGTGGTCC GCGGGCAGCA TCTGCAGGTG CGCCAGGGCC TGGGCGTTGA 13440 GAGGGTACAA CTCGGAGCCG GGGGACTCCG GGGGCCGGTC CGCGCGGTGC CGCGAGTGGG 13500

CACGCTTTGG GGCCCGGGTG TCGGACGCGG GCGCGTTACG GATCCCGACG CGGGGCAGAA 13560

CGTACGTGCG TTGGCGCGGC GATGAGGGGT CCGGGCTGCC GAGGGGGGCG TAGGGGACCG 13620

GGCTAGGCAA GCCCGCGGGT TGCGCGGGGT TCCCGTGGGG GTCTAGGCTC CCTGGGCACC 13680 CGTGGGGGTC GTGGGGGTCG CGGGTCCCTG GGTATGCGCG GGACCCTGGG TTCTCTGGGA 13740

GATCGTGGAA CTCGCGGTTC CCTGGGCTCT CGGGGAACCC GGGGCTCCCT GGGGACACGT 13800

GGTGCCCTGG GAATTCTTGA TGGTCGGACG GCTTCAGATG GCTTCGGGAT CGAGAGGGCC 13860

GCACAGACTC GTAGTAGACC CGAATCTCCA CGTTTCCCCG CCGCCGGATC ATGGTCGCCG 13920 CCCCGGTGCG GGGGCCCGTC GGTCGGAAGC GAGTGCCCTT CAAGCGTGTC CGCTCCTCTG 13980

GGCTGCATGC CGTCGGATGG GGTGCCTTTT AAGGAAAGGT CTCGGCTGCC CGCCCCAACC 14040

GGGGTTTGGG GGTGGGCCGG GGAAACCCCG GATGCCATGG GGGGGGTCAC ACCCTAAGCG 14100

CCGGCGCGCT GGTTGGGTGG GGGTAGAGGG GAGTCCCCGG TCGACGAGAT CGTATCAAGG 14160

GGCCAGCACG CGATCCTGCC GCTCGTTCGA TCTAGCACAC CCACGGGTCT GCTGTGTGGG 14220 ATTTCGACTC GCGGGATCCG ATCGCACGTC CGGAGGACAC AGCAGCGGGA GCTCCGGGTC 14280

GGTCACCGCA GTTCTGGCCG CCTCTCGGTC CTCCCGTTCC CTTTTATGGA TCTCCGCGCA 14340

GACATCGCCA TACGTCCGGT GTGTGCACCG CGAAGAATCC AAAAACATGT CCGTCGTTTT 14400

CAGGGCCCAA GACATGGTGT CCCGTCCACG AAGGCGGCGC CCGGCCTGCG AGAAAGCGCG 14460

GATGTTGGGA TCGGGGCCCC CCCGTCCCGT CCCCCCGTCC CGTCCCCCCG TCCCGTCCCC 14520 CCGTCCCGTC CCCCCGTCCC GTCCCCCCGT CCCGTCCCCC CGTCCCGTCC CCCCGTCCCG 14580

TCCCCCCGTC CCGTCCCCCC GTCCCGTCCC CCCGTCCCGT CCCCCCGTCC CGTCCCCCCG 14640

TCCCGTCCCC CCGTCCCGTC CCCCCGTCCC GTCCCCCCGT CCCGTCCCCC CGCCCCGGCG 14700

CCCCCGGGTC ACCGTACCTG CGATAAGGCT GCAGTGGGTG GATGGGTCCT CGCGGTACGT 14760

ACAGGGTGGG GGGGGGGGGG AGGGAAAGGC AGAACGAAAA GGAACCGATG CGCCCGCGTC 14820 TCTGTATCCG ATCCGATCCG GGTGCGTCGG TGCCCCGCTC GCCGCCGGCG TCTCTGTCTC 14880

GCTGTGGCCC CCTTCGCGAT GCCGCCGCTG CCGTCCCGGT CTCCGCCGCG CAGCCGGTGT 14940

GCCCCTGGTG CGGCGGCGAC CGGGACGCCG GCCCTTTATG TGCGCGAGGA ACGGCCCGCC 15000

CCCCGTCCGG GCCCGCCTCG GGGCGGGGCC CGCGGGATGA CGCGGGCCCC GGGCAGGGCG 15060

CCAGTGCTCG CACTTTGCCC TAATAATATA TATACTATTA GGACGAAGTG CGAACGCTTC 15120 GCGTTCTCAC TTCTTTTACC CTGCGGCCCC GCCCCCTTTG GGGCGGAGCC CGCGGGATGA 15180

CGCGGGCCCC GGGCAGGGCG CCAGTGCTCG CACTTTGCCC TAATAATATA TATACTATTA 15240

GGACGAAGTG CGAACGCTTC GCGTTCTCAC TTCTTTTACC CTGCGGCCCC GCCCCCTTTG 15300

GGGCGGAGCC GCCCGCGGAC CAACGGGGCG ACCTCGCCGG CCCCAAAGGG GCCGGCGGGG 15360

GCCAACGGGA GCGCGGGGCC GGCATCTCAT TACCACGAAC CCGGAAGGGC AGGGGAGCGA 15420 GCCCGCCCGC GACGAGGGTC TCATTAGCAT CGCGGGCGGA AGCGGAAGCC GCCCGCGCCG 15480

GGCGCTAATG AGATGCCGCG CGGGCGGAGC CGGCGGCGGC GCGACCAACG GGCCGCCGCC 15540

ACGGACGCGG ACGCGCGGGC GTCGGGGCGG GGCCGCGCAT AATGCGGTTC CACCTGGGGG 15600

CGGAACCCCG GCGAGCCGGG GCGCGGCGGC GTCGATCGCT CCTCCTCCGC GTCCTCCTCC 15660

TTTCCCCCCG CCCCGCGCGC CCCGAGGACT ATATCAGCCA GGCGACGGGG CGATCGTCCA 15720 CACGGAGCGC GGCTACCGAC GCGGCCGCCA GGATCTACCC GATCGGCGCG GAGAGGCGAA 15780

AAGACACAGG CACACGCACG CACCGCACGG GGGGGAGAGA GAGACCGCCA ACCCCCCCCC 15840

CCCCCCACTG CCGCCCCTGA AGAAGAAGAA GACCCCCCGC ACACCCCGGT CGGAGGCGAT 15900

GTCGGCGGAG CAGCGGAAGA AGAAGAAGAC GACGACGACG ACGCAGGGCC GCGGGGCCGA 15960

GGTCGCGATG GCGGACGAGG ACGGGGGACG TCTCCGGGCC GCGGCGGAGA CGACCGGCGG 16020 CCCCGGATCT CCGGATCCAG CCGACGGACC GCCGCCCACC CCGAACCCGG ACCGTCGCCC 16080

CGCCGCGCGG CCCGGGTTCG GGTGGCACGG TGGGCCGGAG GAGAACGAAG ACGAGGACGA 16140

CGACGCCGCC GCCGATGCCG ATGCCGACGA GGCGGCCCCG GCGTCCGGGG AGGCCGTCGA 16200

CGAGCCTGCC GCGGACGGCG TCGTCTCGCC GCGGCAGCTG GCCCTGCTGG CCTCGATGGT 16260 GGACGAGGCC GTTCGCACGA TCCCGTCGCC CCCCCCGGAG CGCGACGGCG CGGAAGAAGA 16320

AGCAGCCCGC TCGCCTTCTC CGCCGCGGAC CCCCTCCATG TGCGCCGATT ATGGCGAGGA 16380

GAACGACGAC GACGACGATG ACGAGGACCG CGACGCGGGC CGCTGGGTCC GCGGACCGGA 16440

GAACGACGTC CGCGGTCCGC GGGGCGTACC CGGACCCCAT GGCCAGCCTG TCGCCGCGAC 16500 CCCCGGCGCC CCGCCGACAC CACCACCACC ACCACCGCCG CCGCCGCCGG CGCGCCCCCC 16560

GCCGGCGCTC GACCGCCTCT GACTCATCAA AATCCGGATC CTCGTCGTCG GCGTCCTCCG 16620

CCTCCTCCTC CGCCTCCTCC TCCTCGTCTG CATCCGCCTC CTCGTCTGAC GACGACGACG 16680

ACGACGCCGC CCGCGCCCCC GCCAGCGCCG CAGACCACGC CGCGGGCGGG ACCCTCGGCG 16740

CGGACGACGA GGAGGCGGGG GTGCCCGCGA GGGCCCCGGG GGCGGCGCCC CGGCCGAGCC 16800 CGCCCAGGGC CG 16813

(2) INFORMATION FOR SEQ ID NO: 205:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 414 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 205:

Met Ala Asp Ile Pro Pro Asp Pro Pro Ala Leu Asn Thr Thr Pro Ala 1 5 10 15

Asn His Ala Pro Pro Ser Pro Pro Pro Gly Ser Arg Lys Arg Arg Arg

20 25 30

Pro Val Leu Pro Ser Ser Ser Glu Ser Glu Gly Lys Pro Asp Thr Glu 35 40 45 Ser Glu Ser Ser Ser Thr Glu Ser Ser Glu Asp Glu Ala Gly Asp Leu 50 55 60

Arg Gly Gly Arg Arg Arg Ser Pro Arg Glu Leu Gly Gly Arg Tyr Phe 65 70 75 80

Leu Asp Leu Ser Ala Glu Ser Thr Thr Gly Thr Glu Ser Glu Gly Thr 85 90 95

Gly Pro Ser Asp Asp Asp Asp Asp Asp Ala Ser Asp Gly Trp Leu Val

100 105 110

Asp Thr Pro Pro Arg Lys Ser Lys Arg Pro Arg Ile Asn Leu Arg Leu 115 120 125 Thr Ser Ser Pro Asp Arg Arg Ala Gly Val Val Phe Pro Glu Val Trp 130 135 140

Arg Asn Asp Arg Pro Ile Arg Ala Ala Gin Pro Gin Ala Pro Ala Gin 145 150 155 160 Ser Ser Gly Asp Arg Ala Ala Ala Pro Arg Arg Ser Ala Arg Gin Ala

165 170 175

Gin Met Arg Ser Gly Ala Ala Trp Thr Leu Asp Leu His Tyr Ile Arg 180 185 190 Gin Cys Val Asn Gin Leu Phe Arg Ile Leu Arg Ala Ala Pro Asn Pro 195 200 205

Pro Gly Ser Ala Asn Arg Leu Arg His Leu Val Arg Asp Cys Tyr Leu

210 215 220

Met Gly Tyr Cys Arg Thr Arg Leu Gly Pro Arg Thr Trp Gly Arg Leu 225 230 235 240

Leu Gin Ile Ser Gly Gly Thr Trp Asp Val Arg Leu Arg Asn Ala Ile

245 250 255

Arg Glu Val Glu Ala Arg Phe Glu Pro Ala Ala Glu Pro Val Cys Glu 260 265 270 Leu Pro Cys Leu Asn Ala Arg Arg Tyr Gly Pro Glu Cys Asp Val Gly 275 280 285

Asn Leu Glu Thr Asn Gly Gly Ser Thr Ser Asp Asp Glu Ile Ser Asp

290 295 300

Ala Thr Asp Ser Asp Asp Thr Leu Ala Ser His Ser Asp Thr Glu Gly 305 310 315 320

Gly Pro Ser Pro Ala Gly Arg Glu Asn Pro Glu Ser Ala Ser Gly Gly

325 330 335

Ala Ile Ala Ala Arg Leu Glu Cys Glu Phe Gly Thr Phe Asp Trp Thr 340 345 350 Ser Glu Glu Gly Ser Gin Pro Trp Leu Ser Ala Val Val Ala Asp Thr 355 360 365

Ser Ser Ala Glu Arg Ser Gly Leu Pro Ala Pro Gly Ala Cys Arg Ala

370 375 380

Thr Glu Ala Pro Glu Arg Glu Asp Gly Cys Arg Lys Met Arg Phe Pro 385 390 395 400

Ala Ala Cys Pro Tyr Pro Cys Gly His Thr Phe Leu Arg Pro 405 410

(2) INFORMATION FOR SEQ ID NO: 206:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 414 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 206:

Met Ala Asp Ile Pro Pro Asp Pro Pro Ala Leu Asn Thr Thr Pro Ala 1 5 10 15 Asn His Ala Pro Pro Ser Pro Pro Pro Gly Ser Arg Lys Arg Arg Arg 20 25 30

Pro Val Leu Pro Ser Ser Ser Glu Ser Glu Gly Lys Pro Asp Thr Glu

35 40 45

Ser Glu Ser Ser Ser Thr Glu Ser Ser Glu Asp Glu Ala Gly Asp Leu 50 55 60

Arg Gly Gly Arg Arg Arg Ser Pro Arg Glu Leu Gly Gly Arg Tyr Phe 65 70 75 80

Leu Asp Leu Ser Ala Glu Ser Thr Thr Gly Thr Glu Ser Glu Gly Thr 85 90 95 Gly Pro Ser Asp Asp Asp Asp Asp Asp Ala Ser Asp Gly Trp Leu Val 100 105 110

Asp Thr Pro Pro Arg Lys Ser Lys Arg Pro Arg Ile Asn Leu Arg Leu

115 120 125

Thr Ser Ser Pro Asp Arg Arg Ala Gly Val Val Phe Pro Glu Val Trp 130 135 140

Arg Asn Asp Arg Pro Ile Arg Ala Ala Gin Pro Gin Ala Pro Ala Gin

145 150 155 160

Ser Ser Gly Asp Arg Ala Ala Ala Pro Arg Arg Ser Ala Arg Gin Ala

165 170 175 Gin Met Arg Ser Gly Ala Ala Trp Thr Leu Asp Leu His Tyr Ile Arg

180 185 190

Gin Cys Val Asn Gin Leu Phe Arg Ile Leu Arg Ala Ala Pro Asn Pro

195 200 205

Pro Gly Ser Ala Asn Arg Leu Arg His Leu Val Arg Asp Cys Tyr Leu 210 215 220 Met Gly Tyr Cys Arg Thr Arg Leu Gly Pro Arg Thr Trp Gly Arg Leu

225 230 235 240

Leu Gin Ile Ser Gly Gly Thr Trp Asp Val Arg Leu Arg Asn Ala Ile

245 250 255 Arg Glu Val Glu Ala Arg Phe Glu Pro Ala Ala Glu Pro Val Cys Glu

260 265 270

Leu Pro Cys Leu Asn Ala Arg Arg Tyr Gly Pro Glu Cys Asp Val Gly

275 280 285

Asn Leu Glu Thr Asn Gly Gly Ser Thr Ser Asp Asp Glu Ile Ser Asp 290 295 300

Ala Thr Asp Ser Asp Asp Thr Leu Ala Ser His Ser Asp Thr Glu Gly 305 310 315 320

Gly Pro Ser Pro Ala Gly Arg Glu Asn Pro Glu Ser Ala Ser Gly Gly 325 330 335

Ala Ile Ala Ala Arg Leu Glu Cys Glu Phe Gly Thr Phe Asp Trp Thr

340 - 345 350

Ser Glu Glu Gly Ser Gin Pro Trp Leu Ser Ala Val Val Ala Asp Thr 355 360 365

Ser Ser Ala Glu Arg Ser Gly Leu Pro Ala Pro Gly Ala Cys Arg Ala

370 375 380

Thr Glu Ala Pro Glu Arg Glu Asp Gly Cys Arg Lys Met Arg Phe Pro 385 390 395 400 Ala Ala Cys Pro Tyr Pro Cys Gly His Thr Phe Leu Arg Pro

405 410

(2) INFORMATION FOR SEQ ID NO: 207:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 287 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:207:

Met Gly Val Val Val Val Ser Val Val Thr Leu Leu Asp Gin Arg Asn 1 5 10 15

Ala Leu Pro Arg Thr Ser Ala Asp Asp Ala Leu Trp Ser Phe Leu Leu

20 25 30

Arg Gin Cys Arg Ile Leu Ala Ser Glu Pro Leu Gly Thr Pro Val Val 35 40 45

Val Arg Pro Ala Asn Leu Arg Arg Leu Ala Glu Pro Leu Met Asp Leu

50 55 60

Pro Lys Phe Trp Ile Val Arg Thr Arg Ser Cys Arg Cys Pro Pro Asn 65 70 75 80 Thr Thr Thr Gly Leu Phe Ala Glu Asp Asp Pro Leu Glu Ser Ile Glu

85 90 95

Ile Leu Asp Ala Pro Ala Cys Phe Arg Leu Leu His Gin Glu Arg Pro

100 105 110

Gly Pro His Arg Leu Tyr His Leu Trp Val Val Gly Ala Ala Asp Leu 115 120 125

Cys Val Pro Phe Leu Glu Tyr Ala Gin Lys Thr Arg Leu Gly Phe Arg

130 135 140

Phe Ile Ala Met Lys Thr Asn Asp Ala Trp Val Gly Glu Pro Trp Pro 145 150 155 160

Leu Pro Asp Arg Phe Leu Pro Glu Arg Thr Val Ser Trp Thr Pro Phe

165 - 170 175

Pro Ala Ala Pro Asn His Pro Leu Glu Asn Leu Leu Ser Arg Tyr Glu 180 185 190

Tyr Gin Tyr Gly Val Val Val Pro Gly Asp Arg Glu Arg Ser Cys Leu

195 200 205

Arg Trp Leu Arg Ser Leu Val Ala Pro His Asn Lys Pro Arg Pro Ala

210 215 220 Ser Ser Arg Pro His Pro Ala Thr His Pro Thr Gin Arg Pro Cys Phe

225 230 235 240

Thr Cys Met Gly Arg Pro Glu Ile Pro Asp Glu Pro Ser Trp Gin Thr

245 250 255

Gly Asp Asp Asp Pro Gin Asn Pro Gly Pro Pro Leu Ala Val Gly Asp 260 265 270

Glu Trp Pro Pro Ser Ser His Val Cys Tyr Pro Ile Thr Asn Leu 275 280 285

(2) INFORMATION FOR SEQ ID NO: 208:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 479 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 208:

Met Ala Cys Arg Lys Phe Cys Gly Val Tyr Arg Arg Pro Asp Lys Arg

1 5 10 15

Gin Glu Ala Ser Val Pro Pro Glu Thr Asn Thr Ala Pro Ala Phe Pro 20 25 30 Ala Ser Thr Phe Tyr Thr Pro Ala Glu Asp Ala Tyr Leu Ala Pro Gly 35 40 45

Pro Pro Glu Thr Ile His Pro Ser Arg Pro Pro Ser Pro Gly Glu Ala

50 55 60

Ala Arg Leu Cys Gin Leu Gin Glu Ile Leu Ala Gin Met His Ser Asp 65 70 75 80

Glu Asp Tyr Pro Ile Val Asp Ala Ala Gly Ala Glu Glu Glu Asp Glu

85 90 95

Ala Asp Asp Asp Ala Pro Asp Asp Val Ala Tyr Pro Glu Asp Tyr Ala 100 105 110

Glu Gly Arg Phe Leu Ser Met Val Ser Ala Ala Pro Leu Pro Gly Ala

115 - 120 125

Ser Gly His Pro Pro Val Pro Gly Arg Ala Ala Pro Pro Asp Val Arg 130 135 140

Thr Cys Asp Ser Gly Lys Val Gly Ala Thr Gly Phe Thr Pro Glu Glu

145 150 155 160

Leu Asp Thr Met Asp Arg Glu Ala Leu Arg Ala Ile Ser Arg Gly Cys

165 170 175 Lys Pro Pro Ser Thr Leu Ala Lys Leu Val Thr Gly Leu Gly Phe Ala

180 185 190

Ile His Gly Ala Leu Ile Pro Gly Ser Glu Gly Cys Val Phe Asp Ser

195 200 205

Ser His Pro Asn Tyr Pro His Arg Val Ile Val Lys Ala Gly Trp Tyr 210 215 220

Ala Ser Thr Asn His Glu Ala Arg Leu Leu Arg Arg Leu Asn His Pro

225 230 235 240

Ala Ile Leu Pro Leu Leu Asp Leu His Val Val Ser Gly Val Thr Cys

245 250 255 Leu Val Leu Pro Lys Tyr His Cys Asp Leu Tyr Thr Tyr Leu Ser Lys

260 265 270

Arg Pro Ser Pro Leu Gly His Leu Gin Ile Thr Ala Val Ser Arg Gin

275 280 285

Leu Leu Ser Ala Ile Asp Tyr Val His Cys Glu Gly Ile Ile His Arg 290 295 300

Asp Ile Lys Thr Glu Asn Ile Leu Ile Asn Thr Pro Glu Asn Ile Cys

305 310 315 320

Leu Gly Asp Phe Gly Ala Ala Cys Phe Val Arg Gly Cys Arg Ser Ser

325 330 335 Pro Phe His Tyr Gly Ile Ala Gly Thr Ile Asp Thr Asn Ala Pro Glu

340 345 350

Val Leu Ala Gly Asp Pro Tyr Thr Gin Val Ile Asp Ile Trp Ser Ala

355 360 365

Gly Leu Val Ile Phe Glu Thr Ala Val His Thr Ala Ser Leu Phe Ser 370 375 380

Ala Pro Arg Asp Pro Glu Arg Arg Pro Cys Asp Asn Gin Ile Ala Arg 385 390 395 400

Ile Ile Arg Gin Ala Gin Val His Val Asp Glu Phe Pro Thr His Ala 405 410 415 Glu Ser Arg Leu Thr Ala His Tyr Arg Ser Arg Ala Ala Gly Asn Asn 420 425 430

Arg Pro Ala Trp Trp Ala Trp Thr Arg Tyr Tyr Lys Ile His Thr Asp 435 440 445 Val Glu Tyr Leu Ile Cys Lys Ala Leu Thr Phe Asp Ala Ala Leu Arg

450 455 460

Pro Ser Ala Ala Glu Leu Leu- Arg Leu Pro Leu Phe His Pro Lys 465 470 475

(2) INFORMATION FOR SEQ ID NO: 209:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 209:

Val Gly Gly Leu Cys Leu Met Ile Leu Gly Met Ala Cys Leu Leu Glu 1 5 10 15 Val Leu Arg Arg Leu Gly Arg Glu Leu Ala Arg Cys Cys Pro His Ala 20 25 30

Gly Gin Phe Ala Pro 35

(2) INFORMATION FOR SEQ ID NO: 210:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 385 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 210:

Met Gly Arg Leu Thr Ser Gly Val Gly Thr Ala Ala Leu Leu Val Val

1 5 10 15

Ala Val Gly Leu Arg Val Val Cys Ala Lys Tyr Ala Asp Pro Ser Leu 20 25 30

Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Pro Val Leu

35 40 45

Asp Gin Leu Thr Asp Pro Pro Gly Val Lys Arg Val Tyr His Ile Gin 50 55 60

Pro Ser Leu Glu Asp Pro Phe Gin Pro Pro Ser Ile Pro Ile Thr Val 65 70 - 75 80

Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu His Ala 85 90 95

Pro Ser Glu Ala Pro Gin Ile Val Arg Gly Ala Ser Asp Glu Ala Arg

100 105 110

Lys His Thr Tyr Asn Leu Thr Ile Ala Trp Tyr Arg Met Gly Asp Asn 115 120 125 Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Pro Tyr Asn 130 135 140

Lys Ser Leu Gly Val Cys Pro Ile Arg Thr Gin Pro Arg Trp Ser Tyr 145 150 155 160

Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe Leu Met 165 170 175

His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu Val Lys

180 185 190

Ile Asn Asp Trp Thr Glu Ile Thr Gin Phe Ile His Arg Ala Arg Ala 195 200 205 Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro Ala Ala Cys Leu 210 215 220

Thr Ser Lys Ala Tyr Gin Gin Gly Val Thr Val Asp Ser Ile Gly Met 225 230 235 240

Leu Pro Arg Phe Ile Pro Glu Asn Gin Arg Thr Val Ala Lys Leu Lys 245 250 255

Ile Ala Gly Trp His Gly Pro Lys Pro Pro Tyr Thr Ser Thr Leu Leu

260 265 270

Pro Pro Glu Leu Ser Asp Thr Thr Asn Ala Thr Gin Pro Glu Leu Val 275 280 285 Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro Ala Gly Thr 290 295 300

Val Ser Ser Gin Ile Pro Pro Asn Trp His Ile Pro Ser Ile Gin Asp 305 310 315 320

Val Ala Pro His His Ala Pro Ala Ala Pro Ser Asn Pro Gly Leu Ile 325 330 335

Ile Gly Ala Gly Ser Thr Leu Ala Val Leu Val Ile Gly Gly Ile Ala

340 345 350

Phe Trp Val Arg Arg Arg Ala Gin Met Ala Pro Lys Arg Leu Arg Leu 355 360 365 Pro His Ile Arg Asp Asp Asp Ala Pro Pro Ser His Gin Pro Leu Phe 370 375 380

Tyr 385 (2) INFORMATION FOR SEQ ID NO: 211:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 368 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 211:

Met Pro Gly Arg Ser Leu Gin Gly Leu Ala Ile Leu Gly Leu Trp Val 1 5 10 15

Cys Ala Thr Gly Leu Val Val Arg Gly Pro Thr Val Ser Leu Val Ser

20 25 30

Asp Ser Leu Val Asp Ala Gly Ala Val Gly Pro Gin Gly Phe Val Glu 35 40 45 Glu Asp Leu Arg Val Phe Gly Glu Leu His Phe Val Gly Ala Gin Val 50 55 60

Pro His Thr Asn Tyr Tyr Asp Gly Ile Ile Glu Leu Phe His Tyr Pro 65 70 75 80

Leu Gly Asn His Cys Pro Arg Val Val His Val Val Thr Leu Thr Ala 85 90 95

Cys Pro Arg Arg Pro Ala Val Ala Phe Thr Leu Cys Arg Ser Thr His

100 105 110

His Ala His Ser Pro Ala Tyr Pro Thr Leu Glu Leu Gly Leu Ala Arg 115 120 125 Gin Pro Leu Leu Arg Val Arg Thr Ala Thr Arg Asp Tyr Ala Gly Val 130 135 140

Leu Arg Val Trp Val Gly Ser Ala Thr Asn Ala Ser Leu Phe Val Leu 145 150 155 160

Gly Val Ser Ala Asn Gly Thr Phe Val Tyr Asn Gly Ser Asp Tyr Gly 165 170 175

Ser Cys Asp Pro Ala Gin Leu Pro Phe Ser Ala Pro Arg Leu Gly Pro

180 185 190

Ser Ser Val Tyr Thr Pro Gly Ala Ser Arg Pro Thr Pro Pro Arg Thr 195 200 205 Thr Thr Ser Pro Ser Ser Pro Arg Asp Pro Thr Pro Ala Pro Gly Asp 210 215 220

Thr Gly Thr Pro Ala Pro Ala Ser Gly Glu Arg Ala Pro Pro Asn Ser 225 230 235 240 Thr Arg Ser Ala Ser Glu Ser Arg His Arg Leu Thr Val Ala Gin Val

245 250 255

Ile Gin Ile Ala Ile Pro Ala- Ser Ile Ile Ala Phe Val Phe Leu Gly 260 265 270 Ser Cys Ile Cys Phe Ile His Arg Cys Gin Arg Arg Tyr Arg Arg Pro 275 280 285

Arg Gly Gin Ile Tyr Asn Pro Gly Gly Val Ser Cys Ala Val Asn Glu

290 295 300

Ala Ala Met Ala Arg Leu Gly Ala Glu Leu Arg Ser His Pro Asn Thr 305 310 315 320

Pro Pro Lys Pro Arg Arg Arg Ser Ser Ser Ser Thr Thr Met Pro Ser

325 330 335

Leu Thr Ser Ile Ala Glu Glu Ser Glu Pro Gly Pro Val Val Leu Leu 340 345 350 Ser Val Ser Pro Arg Pro Arg Ser Gly Pro Thr Ala Pro Gin Glu Val 355 360 365

(2) INFORMATION FOR SEQ ID NO: 212:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 528 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 212:

Met Arg Ala Gly Leu Val Phe Phe Val Gly Val Trp Val Val Ser Cys 1 5 10 15

Leu Ala Ala Ala Pro Arg Thr Ser Trp Lys Arg Val Thr Ser Gly Glu

20 25 30

Asp Val Val Leu Leu Pro Ala Pro Ala Gly Pro Glu Glu Arg Thr Arg 35 40 45

Ala His Lys Leu Leu Trp Ala Ala Glu Pro Leu Asp Ala Cys Gly Pro

50 55 60

Leu Arg Pro Ser Trp Val Trp Pro Pro Arg Arg Val Leu Glu Thr Val 65 70 75 80 Val Asp Ala Ala Cys Met Arg Ala Pro Glu Pro Leu Ala Ile Ala Tyr

85 90 95

Ser Pro Pro Phe Pro Ala Gly Asp Glu Gly Ser Glu Leu Ala Trp Arg 100 105 110 Asp Arg Val Ala Val Val Asn Glu Ser Leu Val Ile Tyr Gly Ala Leu

115 120 125

Glu Thr Asp Ser Gly Thr Leu- Ser Val Val Gly Leu Ser Asp Glu Ala

130 135 140 Arg Gin Val Ala Ser Val Val Leu Val Val Glu Pro Ala Pro Val Pro

145 150 155 160

Thr Pro Thr Pro Asp Asp Tyr Asp Glu Glu Asp Asp Ala Gly Val Ser

165 170 175

Thr Pro Val Ser Val Pro Pro Pro Thr Pro Pro Arg Gly Pro Pro Val 180 185 190

Ala Pro Pro Thr His Pro Arg Val Ile Pro Glu Val Ser His Val Arg

195 200 205

Gly Val Thr Val His Met Pro Glu Ala Ile Leu Phe Ala Pro Gly Glu

210 215 220 Thr Phe Gly Thr Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gly

225 230 235 240

Pro Tyr Ala Met Asp Val Val Trp Met Arg Phe Asp Val Pro Ser Ser

245 250 255

Cys Ala Glu Met Arg Ile Tyr Glu Ala Cys Leu Tyr His Pro Gin Leu 260 265 270

Pro Glu Cys Leu Ser Pro Ala Asp Ala Pro Cys Ala Val Ser Ser Trp

275 280 285

Ala Tyr Arg Leu Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Thr

290 295 300 Pro Pro Pro Arg Cys Phe Ala Glu Ala Arg Met Glu Pro Val Pro Gly

305 310 315 320

Leu Ala Trp Leu Ala Ser Thr Val Asn Leu Glu Phe Gin His Asp Gin

325 330 335

His Ala Gly Leu Cys Val Val Tyr Val Asp Asp His Ile His Ala Trp 340 345 350

Gly His Met Thr Ile Ser Thr Ala Ala Gin Tyr Arg Asn Ala Val Val

355 360 365

Glu Gin His Leu Pro Gin Arg Gin Pro Glu Pro Val Glu Pro Trp His

370 375 380 Val Arg Ala Pro Pro Pro Ala Pro Ser Arg Pro Leu Arg Leu Gly Ala

385 390 395 400

Val Leu Gly Ala Ala Leu Leu Leu Ala Ala Leu Gly Leu Ser Ala Trp

405 410 415

Ala Cys Met Thr Cys Trp Arg Arg Arg Ser Trp Arg Ala Val Lys Ser 420 425 430

Arg Ala Ser Ala Thr Gly Pro Thr Tyr Ile Arg Val Ala Asp Ser Glu

435 440 445

Leu Tyr Ala Asp Trp Ser Ser Asp Ser Glu Gly Glu Arg Asp Gly Ser 450 455 460

Leu Trp Gin Asp Pro Pro Glu Arg Pro Asp Ser Pro Ser Thr Asn Gly 465 470 - 475 480

Ser Gly Phe Glu Ile Leu Ser Pro Thr Ala Pro Ser Val Tyr Pro His

485 490 495

Ser Glu Gly Arg Lys Ser Arg Arg Pro Leu Thr Thr Phe Gly Ser Gly

500 505 510

Ser Pro Gly Arg Arg His Ser Gin Ala Ser Tyr Ser Ser Val Leu Trp 515 520 525

(2) INFORMATION FOR SEQ ID NO: 213:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:213:

Val His Ala Val Asp Ala Pro Ser Gin Phe Val Thr Trp Leu Ala Val 1 5 10 15 Arg Trp Leu Arg Gly Ala Val Gly Leu Gly Ala Val Leu Cys Gly Ile 20 25 30

Ala Phe Tyr Val Thr Ser Ile Arg Ala 35 40

(2) INFORMATION FOR SEQ ID NO: 214:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 85 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 214:

Met Thr Ser Arg Pro Ala Asp Gin Asp Ser Val Arg Ser Ser Ala Ser 1 5 10 15 Val Pro Leu Tyr Pro Ala Asp Val Pro Ala Glu Ala Tyr Tyr Ser Glu

20 25 30

Ser Glu Asp Glu Ala Ala Asn- Asp Phe Leu Val Arg Met Gly Arg Gin 35 40 45 Gin Ser Val Leu Arg Arg Arg Arg Arg Arg Thr Arg Cys Val Gly Leu 50 55 60

Val Ile Ala Cys Leu Val Val Leu Ser Gly Gly Phe Gly Ala Leu Leu 65 70 75 80

Val Trp Leu Leu Arg 85

(2) INFORMATION FOR SEQ ID NO: 215:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 227 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 215:

Met Ser Ala Glu Gin Arg Lys Lys Lys Lys Thr Thr Thr Thr Thr Gin 1 5 10 15

Gly Arg Gly Ala Glu Val Ala Met Ala Asp Glu Asp Gly Gly Arg Leu

20 25 30

Arg Ala Ala Ala Glu Thr Thr Gly Gly Pro Gly Ser Pro Asp Pro Ala 35 40 45 Asp Gly Pro Pro Pro Thr Pro Asn Pro Asp Arg Arg Pro Ala Ala Arg 50 55 60

Pro Gly Phe Gly Trp His Gly Gly Pro Glu Glu Asn Glu Asp Glu Asp 65 70 75 80

Asp Asp Ala Ala Ala Asp Ala Asp Ala Asp Glu Ala Ala Pro Ala Ser 85 90 95

Gly Glu Ala Val Asp Glu Pro Ala Ala Asp Gly Val Val Ser Pro Arg

100 105 110

Gin Leu Ala Leu Leu Ala Ser Met Val Asp Glu Ala Val Arg Thr Ile 115 120 125 Pro Ser Pro Pro Pro Glu Arg Asp Gly Ala Glu Glu Glu Ala Ala Arg 130 135 140

Ser Pro Ser Pro Pro Arg Thr Pro Ser Met Cys Ala Asp Tyr Gly Glu 145 150 155 160 Glu Asn Asp Asp Asp Asp Asp Asp Asp Asp Arg Asp Ala Gly Arg Trp

165 170 175

Val Arg Gly Pro Glu Asn Asp Val Arg Gly Pro Arg Gly Val Pro Gly 180 185 190 Pro His Gly Gin Pro Val Ala Ala Thr Pro Gly Ala Pro Pro Thr Pro 195 200 205

Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Arg Pro Pro Pro Ala Leu

210 215 220

Asp Arg Leu 225

(2) INFORMATION FOR SEQ ID NO: 216:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 227 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 216:

Met Ser Ala Glu Gin Arg Lys Lys Lys Lys Thr Thr Thr Thr Thr Gin 1 5 10 15

Gly Arg Gly Ala Glu Val Ala Met Ala Asp Glu Asp Gly Gly Arg Leu

20 25 30

Arg Ala Ala Ala Glu Thr Thr Gly Gly Pro Gly Ser Pro Asp Pro Ala 35 40 45 Asp Gly Pro Pro Pro Thr Pro Asn Pro Asp Arg Arg Pro Ala Ala Arg 50 55 60

Pro Gly Phe Gly Trp His Gly Gly Pro Glu Glu Asn Glu Asp Glu Asp 65 70 75 80

Asp Asp Ala Ala Ala Asp Ala Asp Ala Asp Glu Ala Ala Pro Ala Ser 85 90 95

Gly Glu Ala Val Asp Glu Pro Ala Ala Asp Gly Val Val Ser Pro Arg

100 105 110

Gin Leu Ala Leu Leu Ala Ser Met Val Asp Glu Ala Val Arg Thr Ile 115 120 125 Pro Ser Pro Pro Pro Glu Arg Asp Gly Ala Glu Glu Glu Ala Ala Arg 130 135 140

Ser Pro Ser Pro Pro Arg Thr Pro Ser Met Cys Ala Asp Tyr Gly Glu 145 150 155 160 Glu Asn Asp Asp Asp Asp Asp Asp Asp Asp Arg Asp Ala Gly Arg Trp

165 170 175

Val Arg Gly Pro Glu Asn Asp-Val Arg Gly Pro Arg Gly Val Pro Gly 180 185 190 Pro His Gly Gin Pro Val Ala Ala Thr Pro Gly Ala Pro Pro Thr Pro 195 200 205

Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Arg Pro Pro Pro Ala Leu

210 215 220

Asp Arg Leu 225

(2) INFORMATION FOR SEQ ID NO: 217:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 217:

CGCCCGCGTT TCTGCCGCCC GCGCGCTCCT GTGTGGACCC CGGGGTGGGC GGCGGGGGGG 60

GTGCCGTGGG TGTGGCGGCG GGGCGCGGGC CGGGGCCGGG GCTCGCTGGT CTGCCGAAGT 120 AAAGAAAAGA TCGCCACCGT GTGTTCGTCT GTGTGTTCTG CGCGGCGCCG GGGCCCCCCT 180

GCCGGGCGGG GCGGTGGGGC GGGGCCGGGG TCGCGGCGGG GAAGGAAGGA AAGGCCCCGG 240

AAGCGCCGGG AGGGGGCGCC GGCGCGACGC GGGCGGCCGG GCGGGGGCGC GCGGCGGCCG 300

GGCGGGGGCG CGCGGCGGCC GGGCGGGGGC GCGCGGCGGC CGGGCGGGGG CGCGCTTTCC 360

CCGCGTCGCC CCTCGGGTTC CCAAGACCTA TCACGTGTGC GCAGGGGAGG GGAGGACGCG 420 GGGGAGGGGA GGACGCGGGG GAGGGGAGGA CGCGGGGGAG GGGAGGACGC GGGGGAGGGG 480

AGGACGCGGG GGATATATAA AGCGGTAGAA AGCGCGGGAA TGGGCATATT GGACCCGCGT 540

GATTCGGTTG CTCGCGGTTG TCTTGTTTGG ACGTTTTTTA TGCGGGAACA AGGGGGCTTA 600

CCGGTTACAC TGTCCGCTCG CTATGGGGTT CGTCTGTCTG TTTGGGCTTG TCGTTATGGG 660

AGCCTGGGGG GCGTGGGGTG GGTCACAGGC AACCGAATAT GTTCTTCGTA GTGTTATTGC 720 CAAAGAGGTG GGGGACATAC TAAGAGTGCC TTGCATGCGG ACCCCCGCGG ACGATGTTTC 780

TTGGCGCTAC GAGGCCCCGT CCGTTATTGA CTATGCCCGC ATAGACGGAA TATTTCTTCG 840

CTATCACTGC CCGGGGTTGG ACACGTTTTT GTGGGATAGG CACGCCCAGA GGGCGTATCT 900

GGTTAACCCC TTTCTCTTTG CGGCGGGATT TTTGGAGGAC TTGAGTCACT CTGTGTTTCC 960

GGCCGACACC CAGGAAACAA CGACGCGCCG GGCCCTTTAT AAAGAGATAC GCGATGCGTT 1020 GGGCAGTCGA AAACAGGCCG TCAGCCACGC ACCCGTCAGG GCCGGGTGTG TAAACTTTGA 1080

CTACTCACGC ACTCGCCGCT GCGTCGGGCG ACGCGATTTA CGGCCTGCCA ACACCACGTC 1140

AACGTGGGAA CCGCCTGTGT CGTCGGACGA TGAAGCGAGC TCGCAGTCGA AGCCCCTCGC 1200

CACCCAGCCG CCCGTCCTCG CCCTTTCGAA CGCCCCCCCA CGGCGGGTCT CCCCGACGCG 1260 AGGTCGGCGC CGGCATACTC GCCTCCGACG CAACTAGCCA CGTCTGCATC GCAAGCCACC 1320

CTGGGTCGGG AGCAGGATAT CCGACCCGTC TAGCGGCCGG GTCGGCTGTC CAGCGTCGTC 1380

GCCCTAGAGG CTGTCCGCCG GGCGTGATGT TTTCCGCATC TACGACCCCC GAACAGCCCC 1440

TGGGGCTGTC GGGCGATGCG ACGCCGCCCC TGCCGACTTC CGTGCCCCTG GACTGGGCCG 1500 CGTTTCGGCG CGCGTTTCTG ATCGACGACG CCTGGCGGCC CCTGTTGGAG CCGGAGCTCG 1560

CGAACCCCCT AACCGCGCGC CTCCTCGCGG AGTATGACCG TCGGTGCCAG ACCGAAGAGG 1620

TGCTGCCGCC GCGGGAGGAT GTGTTCTCCT GGACGCGGTA TTGTACCCCC GACGACGTGC 1680

GCGTGGTTAT CATCGGGCAG GACCCGTACC ACCATCCCGG CCAGGCGCAC GGCCTGGCGT 1740

TTAGCGTGCG TGCGGATGTG CCGGTGCCTC CGAGTCTACG GAACGTGCTG GCGGCGGTAA 1800 AAAATTGTTA CCCCGACGCG CGCATGAGCG GCCGCGGCTG CCTGGAAAAG TGGGCTCGCG 1860

ACGGCGTGCT GTTGTTGAAC ACGACCCTGA CCGTCAAGCG CGGGGCGGCG GCGTCCCACT 1920

CCAAGCTTGG ATGGGACCGC TTTGTGGGCG GGGTGGTCCG ACGGCTGGCC GCGCGCCGCC 1980

CGGGCCTGGT CTTTATGCTC TGGGGCGCCC ATGCCCAGAA CGCGATCAGG CCCGACCCTC 2040

GCCAACACTA CGTCCTCAAG TTTTCTCACC CGTCGCCCCT CTCCAAGGTC CCGTTTGGGA 2100 CGTGCCAGCA TTTCCTCGCC GCGAATCGCT ACCTCGAAAC CCGGGACATT ATGCCTATCG 2160

ACTGGTCGGT ATAAGATGCC GACATCCGGG GTCTTGATTT ACGAGGGGGC AATTAATAAA 2220

GACTGTTGAT GGTTAAATCT CGGGTCTCAT ACCGGTCCGT GATGTCGGGC GTGGGGGAAG 2280

AGAGGGTCCC CTCTGCGTTT ACTATCCTTG CCTCGTGGGG CTGGACGTTT GCACCCCAGA 2340

ACCATGATCC TGGCGCGTCG CCGAATACGA CGCCCATAGA GTCGATTGCG GGGACCGCAC 2400 CGGACGCGCA CGTGGGGCCT CTCGACGGAG AGCCGGACCG GGATGCGATC TCCCCGCTTA 2460

CGTCGAGCGT GGCCGGCGAC CCGCCGGGGG CGGACGGCCC CTACGTCACC TTTGATACTC 2520

TGTTTATGGT ATCTTCGATC GACGAACTGG GGCGCCGCCA GCTCACGGAT ACGATCCGTA 2580

AGGACCTGCG GCTGTCGCTG GCCAAGTTCA GCATCGCGTG TACCAAGACC TCGTCGTTTT 2640

CGGGGACGGC CGCGCGCCAG CGCAAGCGCG GAGCACCGCC GCAACGCACA TGCGTACCAC 2700 GCAGCAACAA GAGCCTCCAG ATGTTCGTTT TGTGCAAGCG CGCCAACGCC GCGCAGGTGC 2760

GCGAGCAGCT GCGGGCGGTT ATTCGGTCGC GCAAGCCGCG CAAGTATTAC ACGCGGTCCT 2820

CGGATGGGCG GCTCTGCCCG GCCGTCCCCG TGTTTGTACA CGAGTTTGTT TCGTCCGAAC 2880

CCATGCGCCT CCATCGAGAT AACGTCATGC TGTCTACGGA ACCAGACTAA GCACCCCCGC 2940

CGTCCCCTTT CTTTTCCCCC TACCCTTCCC CCCGTTACTG ATGTGTTGTG ACGTTTCAAT 3000 AAATAACACG TAGCTTATTT TGTTGGATGA TGGATTGATT GATTTTATTG ACCGTTCGTT 3060

CGCCCGGCGG TGCCGTCGCC GCGCGCAGAG GGAATATGCA AGCGGGCGGG GTGGGGAGGA 3120

AAGAAGGTTT CAGGTTCCGG GGGTTGGGTC TGCGTCGTCC AGGGTGGGGC TGATCTGAAT 3180

TTCCCGCAGA ACCTCGACCA GTAGGTCTGT TGTGTTTGCT GGGAACTCGC CCGCCGTTGG 3240

GGATACGGGG GCGGGGGGTG TGGTTGGGCG GACGTCCAGG GGTGCGTTAT CGCACCCCCG 3300 CGCCGCCTCG GGGGCCGTCC CGTAGATCGT TGCGGTGATG TAGATGGTGT CCGGGGTCCA 3360

CACCACCGTC AGGATGCCGG CCGTCGCACT CCGGACGCTT TCGCCGTGCG ATGAGCTGAC 3420

CCAGGAGTCA AAGGGGTACG CGTACATATG GGCGTCCCAC CAGCGCTCCA GCCTCTGGGT 3480

ACTAGCGCGT CCTATAAAGC GGTATGCGCA AAATTCGGCA CGACAGTCGA TAATCACCAG 3540

CAGCCCGATG GGGGTGTGTT GTATCACCAC GCCTCCGCGG GGCAGGCGGT CCTGGCGCGC 3600 TCGACCCCGC GTCAGAACCG CGCGCGTCCC TGACTCAAAC ACGTGCACCA CCTGTGCCGC 3660

GTCCGGCAGC GCGCTCGTTA GCGACGCCCT GGGGTGATGT AGGCTGTACG CGATGGTCGT 3720

CTGGGGGTTC CCCATGTCTC GGGGGGGTGG GGGTGAATGT CACCCGGCCC GGGTGCGGTG 3780

GGAACGCGAG GGAATGGAGG GTTAATAGAC AATGACCACA TTCGGATCGC GTAGAGCAGA 3840 TAGTATGTGC TCGCTAATGA CGTCATCGCG TTCGTGGCGC TCCCGGAGCG GGTTTAGATT 3900

CATGTGCAGG AACTCGGATG AGGTGGTGCG GGACATGGCT ACGTACGCGC TGTTTAGGCG 3960

CAGGTTTCCG GGCGTGAAGC ATATGGCGAC CTTGTCCAGA CTGAGCCCCT GGGAGCGCGT 4020

GATGGTCATC GCGAGTTTGG AGCTGATGCC GTAGTCGGCG TTGATGGCCA TGGCCAGCTC 4080 CGTGGAGTCG ATCGACTCGA CAAACTCACT GATGTTGGTA TTGACGACAG ACATGAAGCC 4140

GTGCTGGTCC CGCAGGACGA TGTAGGGCAG GGGGGACTCC TCCAAGAACT CGGCCACGCC 4200

GGCCGTCGCG TGCCGCCGCC GCAGCTCCTC CGCGAACGCG AACACCCGGG TGTACGTGTA 4260

CCCCATCAGC GTGTAGTTGT CCGTCTGCAG GGCCACGGAC ATCAGCCCCC CGCGCGGCGA 4320

GCCGGTCAGC AGCTCGCAGC CCCGGAAGAT GACATTGTCC ACGTAGGTGC TGAAGGGGGC 4380 GCTCTCAAAC ACCTCCCCGA AGAGCTCCCG TAGGATAAGG TATCGCCCCA GAAAGGCCCT 4440

CTTCAGGAGC CCAAACTGGG CGTGGACGGC CGCGGTGGTC TCCGGCTCTT CGAGGGCGTA 4500

GTGGCAGTAG AACACGTCCA GCTGCTGTTC GTCCAGCCCG GCGAAGATAA CGTCAAGGTC 4560

GTCGTCGGGG AAGTCGTCCG GGCCCCCGTC CCGCGGGCCC AGGTGCTTAA AATTGAACGC 4620

ACGCTCCCCC GGAGAGCGGT CGCTGGTGTC GGCGGCCCTG GTTGCCGATG CGCCGGCGGC 4680 GTCCCGGCGT AGCGACAGGA GTTCTGCCGT CAGCTCCCCT AGGCGGCCGT AGGCCAGGGT 4740

CCTCTGGGTC GCGTCCAGGC CGGGGCGCTG GAGAAAGTTG TAAAAGTGAA TCAGCCCGCC 4800

GAACATGAGC CGCGACAGGA ACCGGTAGGC GAACTCCACC GAGGTCTCCC CCTGGGTCTT 4860

CACGAAGCTG TCGTCGCGCA GCACAGCCTC GAAGGTCCGA AACGTCCCGT CGAACCCAAA 4920

CACCATCTTT CGGAGGCGCG CGGTCACCGC GACCTGGCTG TTGAGGACGT ACGTGATGTC 4980 GTTCCGGGCC ACGACTAGCT GTTGCTTGCT GTGCACCTCA CAGCGCACGT GCCCCGCGTC 5040

CTGGTCCTGA CTCTGGGAGT AGTTGGTGAT GCGACTGGCG TTGGCCGTGA TCCACTTTTC 5100

CATGGTCAGC GTGGGTTGCT GCGTGAGCCG TCGATACTCG TCAAACTCTT TGACCGACAC 5160

AAACGTAAGC ACGGGGAGGG TAAACACAAC AAACTCCCCC TCGCGAGTCA CCTTTAGGTA 5220

GGCGTGGAGC TTGGCCATGT ACGCGCTGAC CTCCTTGTGG GACGAGAACA GCCGCGTCCA 5280 CCCCGGAAGG TTGGCCGGGT TGGTGATGTA ACTTTCCGGG ACGACAAAGC GGTCCACAAA 5340

CTGCATGTGC TCCTCGGTGA TGGGAAGGCC GTACTCCAGC ACCTTCATGA GGTTCCCGAA 5400

CTCGTGCTCC ACACATCGCT TGTTGTTAAT GAAAATGGCC CAGCTGTGCG AGAGGCGCGT 5460

GTACTCGCGT AGGGTGCGGT TGCAGATGAG GTACGTGAGC ACGTTTTCGC TCTGCCGGAC 5520

GGAGCATCGC AGTTTTTGGT GTTCGAAGGT GGACTCCAGC GAGGCCGTCT GGGTCGGCGA 5580 CCCCACGCAC ACCAGCACCG GCCGCAGGCG GCCCGCGTAC TGGGGGGTGT GGTACAGGGC 5640

GTTAATCATC CACCAGCAAT ACACCACGGT CGTGAGTAGG TGCCGCCCCA GGAGCCCGGC 5700

CTCGTCGATG ACGATAATGT TGCTGCGGGT GAAAGCCGGC AGCGCCCCGT GTGTGACCGA 5760

GGCCAGGCGC GTGAGGGCAC CCTGGCCCAG CCCCAAAGTC TGCTCTAGGG CGGTGAGGGC 5820

GTGGAACTCG TTTCGCGCGT CTTCGCCCCC GTGCGCCGCC AGGGCCCGCT TGGTGATGTC 5880 GAGGATCACC TCCCAGTAGT ACGTCAGGTC TCGCCGCTGC AGGTCTTCCA GCGAGGCGGG 5940

GCTGCTGGCC AGGGTGTACG GGTGCTGCCC CAGCTGGGCC TGGACGTGAT TCCCGCGAAA 6000

CCCGAACTCG TGAAAGATGG TGTTGATGGG TCGACTCAGA AACGCCCCCG AGAGCTTAAC 6060

GTACATGTTC TGCGCCGCGA TTCGCGTGGC GCCCGTGACC ACGCAGTCCA GGACCTCGTT 6120

GAGGGTCTGC ACGCACGTAC TCTTTCCGGA TCCGGCGTTG CCGGTGATGA GATACGCCGC 6180 GAACGGAAAC TCCCGGAGCG GCAGGCCGGT CGGGACCTCC AAGGCCGCCA CGTCCCGGAA 6240

CCACTGCAGG CGCGGCACCT GCGTGACGTC GAGCTGCTGC TGCGAGAGCT CTCGGATGCG 6300

TGCGATGATT GGTTGGACCC CGTGCATGGA CGTAAAATTT AAAAACGCCT CGTCCCTGAA 6360

CCGCACGGCG GGTCTGGCCC CGGGCTGCTG TGGGGGCGGA CCTGGTGCCC GGACGTCCCG 6420 CGAGCCCTCC CCGCCGGACG CCGCCATGGC CGCACAGCGC GCGCGGGCGC CGGCGATGCG 6480

GACGCGGGGC GGCGACGCGG CGCTATGCGC CCCCGAGGAC GGCTGGGTGA AGGTTCACCC 6540

CACCCCCGGG ACGATGTTGT TCCGCGAGAT TCTCCTCGGG CAGATGGGGT ACACCGAGGG 6600

TCAGGGGGTG TACAACGTCG TCCGGTCCAG CGAGGCCGCC ACCCGACAGC TGCAGGCGGC 6660 GATCTTCCAC GCGCTCCTCA ACGCCACAAC GTACCGGGAC CTGGAGGAGG ACTGGCGCCG 6720

CCACGTGGTG GCCCGCGGCC TCCAGCCGCA GCGGCTGGTT CGCAGGTACC GGAACGCCCG 6780

GGAGGGCGAT ATCGCCGGGG TGGCCGAGCG GGTGTTCGAC ACGTGGCGAT GCACGCTCAG 6840

GACGACGCTG CTGGACTTTG CCCACGGGGT GGTAGACTGC TTTGCGCCGG GCGGCCCAAG 6900

CGGACCGACC AGCTTCCCCA AATATATCGA CTGGCTGACG TGTCTGGGGC TGGTTCCCAT 6960 ATTGCGCAAG ACGCGCGAGG GGGAGGCGAC GCAGCGCCTG GGGGCGTTTC TCAGGCAGCA 7020

CACGCTGCCC CGGCAGCTGG CCACGGTCGC CGGGGCCGCG GAGCGCGCCG GCCCGGGGCT 7080

TCTGGAGCTG GCCGTCGCGT TCGACTCCAC GCGCATGGCG GAATACGACC GTGTGCACAT 7140

CTACTACAAC CATCGCCGGG GGGAGTGGCT GGTGCGCGAC CCGGTCAGCG GGCAGCGCGG 7200

CGAGTGCCTG GTGCTGTGCC CCCCCCTGTG GACCGGCGAC CGCCTGGTCT TCGATTCGCC 7260 CGTTCAGCGG CTGTGCCCCG AGATCGTCGC GTGCCACGCC CTCCGGGAAC ACGCGCACAT 7320

CTGCCGTCTG CGCAACACCG CGTCCGTCAA GGTGCTGTTG GGGCGCAAGA GCGACAGCGA 7380

GCGCGGGGTG GCTGGCGCCG CGCGGGTCGT CAATAAGGCG CTGGGGGAGG ATGACGAGAC 7440

GAAGGCCGGC TCGGCCGCCT CGCGTCTCGT GCGGCTCATC ATCAACATGA AGGGCATGCG 7500

CCACGTGGGC GACATCAACG ACACGGTACG CGCCTACTTG GACGAGGCGG GGGGGCACCT 7560 GATCGACACC CCCGCCGTCG ACCACACCCT CCCTGGGTTC GGCAAGGGCG GCACCGGCCG 7620

CGGGTCGGCG GCCCAGGACC CGGGGGCGCG ACCGCAGCAG CTTCGCCAGG CGTTTCAGAC 7680

GGCCGTGGTC AACAACATCA ACGGCATGCT GGAGGGCTAT ATCAATAATC TCTTTGGAAC 7740

CATAGAACGC CTGCGAGAGA CGAACGCGGG TCTGGCGACC CAGCTGCAGG CGCGCGACCG 7800

CGAGCTGCGG CGCGCCCAGG CGGGGGCGCT GGAGCGGGAG CAGCGCGCGG CGGACCGGGC 7860 GGCCGGGGGA GGCGCGGGCC GCCCGGCGGA GGCGGATCTT CTCCGGGCCG ACTACGACAT 7920

TATCGACGTC AGCAAGTCCA TGGACGACGA CACGTACGTG GCCAACAGTT TCCAGCACCA 7980

GTACATCCCC GCGTACGGCC AGGACCTCGA GCGCCTGTCG CGCCTCTGGG AGCACGAGCT 8040

GGTGCGCTGC TTCAAGATTC TGCGCCACCG CAACAACCAG GGCCAGGAAA CGTCGATCTC 8100

GTACTCTAGC GGGGCGATCG CCTCCTTCGT GGCCCCGTAT TTCGAGTACG TGCTTCGCGC 8160 CCCCCGAGCG GGCGCGCTCA TCACCGGCTC CGATGTCATC CTAGGGGAGG AGGAGTTATG 8220

GGAGGCGGTC TTTAAGAAAA CCCGCCTGCA GACGTACCTG ACAGACGTCG CGGCCCTGTT 8280

CGTGGCGGAC GTACAGCACG CGGCTCTGCC CCGGCCCCCC TCCCCAACCC CCGCCGATTT 8340

CCGGGCGAGC GCGTCCCCGC GGGGCGGGTC CCGGTCCCGG ACCCGGACCC GATCCCGGTC 8400

GCCCGGGAGA ACGCCGAGGG GTGCGCCGGA CCAGGGCTGG GGCGTCGAAC GCAGGGATGG 8460 CCGACCCCAC GCCCGCCGAT GAGGGAACGG CCGCCGCCAT CCTCAAACAG GCCATCGCCG 8520

GGGACCGCAG TCTGGTCGAG GTGGCGGAGG GGATCAGCAA CCAGGCGCTG CTGCGCATGG 8580

CCTGCGAGGT GCGCCAGGTC AGCGATCGCC AGCCGCGGTT TACCGCGACC AGCGTCCTGC 8640

GCGTTGACGT CACCCCCAGG GGGCGGTTGC GGTTCGTTCT GGACGGGAGT TCCGACGACG 8700

CGTACGTGGC GTCGGAGGAT TACTTTAAGC GCTGCGGGGA CCAGCCGACG TATCGCGGTT 8760 TTGCGGTCGT CGTCCTCACG GCCAACGAGG ACCACGTGCA CAGCCTGGCC GTGCCCCCCC 8820

TCGTTCTGCT GCACCGGCTC TCCTTGTTTC GCCCCACGGA CCTCCGGGAC TTCGAGCTCG 8880

TCTGCCTGCT GATGTACCTG GAGAACTGTC CCCGGAGCCA CGCCACGCCC TCGCTGTTCG 8940

TCAAGGTGTC GGCGTGGTTG GGGGTCGTGG CCCGCCACGC GTCTCCCTTC GAGCGCGTCC 9000 GCTGCCTTCT CCTCCGCAGC TGCCACTGGA TCCTGAACAC GCTAATGTGC ATGGCGGGCG 9060

TGAAGCCCTT CGACGACGAG CTAGTCCTGC CCCACTGGTA CATGGCCCAC TACCTGCTGG 9120

CCAACAATCC GCCCCCCGTC CTCTCGGCCC TGTTTTGCGC CACCCCGCAG AGCTCTGCGT 9180

TGCAGTTGCC CGGGCCCGTC CCCCGCACGG ACTGTGTGGC CTATAACCCG GCCGGCGTCA 9240 TGGGAAGCTG CTGGAAATCC AAGGACCTGC GTTCGGCTCT GGTGTATTGG TGGCTTTCGG 9300

GGAGCCCCAA ACGACGGACC TCGTCGCTTT TCTATCGGTT TTGCTAACTC CGGAAAATAA 9360

ACGTGTTTTT TATGGAACGT TCCCTACCTG TCGTGTCATC TCTCGGGGGA TGGTGGTGGG 9420

CCTGTGTGTG TGTCTTGTGC ACCGAAGGAG GAAAGTGGGG GGGTGGTGGT GCTGGTGGTG 9480

GAAAGACATG ATAGAGGGAA CAAAGAAATA GAAGAAAACC ACAACCGGCG CGTGTCAGTA 9540 AATACGGACG CGCGCACACG CGGGGGTAAG TTGGAGCACG GGGCCCCAGT TTATTGACCA 9600

AATTCAGGGA AACAGAAACC GCATCTTTTC CTCGAAAGGG TACACAAAGC TCCCGCCCTC 9660

GCCCCACACG CCTTCCAGAA CCCCCGTAAA CACCAGTTGA ATCTCGCGCA GGATCTCGCG 9720

CAGGTGATGG GCGCAGTCCA CGGGGGGGAG CACCAAGGGC CGCGGGTACA GATCCACGGG 9780

GACGCCGACC GACTCCCCGC CCCCGGGACA TACGCGCACG ACGCGTCTCC AGTATTGCTC 9840 CGCGTCCAGC AGGGCGCCTC CGCGGAAGGC CGTTTGGGGC AGGGGGTCGT CGGCCTCGCC 9900

CGGGGGGGTC AGAACGCTCC AGTACTCCGC GTCCAGACGC CTCCCGAAGG CATCCAGGAC 9960

AAAGCGGTCA CAGGCGTCCT CCATGATGCC CCGGGCCGCG CACACGGCCT CCTCCGGCGG 10020

GCCGGCGGCC GGCCGCCGGA GGATTCGTCT CAGCGCGTCG CGCATAACCT CGGCCGCCGC 10080

GGCGTACGCG GGCCCGCGGA GAGGAAATCC CTGCAGGAAG TCGGTGTCAT CGCGGGAGTT 10140 CCAGAACCAC GCCCCGGTCT GGCTCCAGGT GACGACGTGG GTGTAGACGC CCTCTAGCGC 10200

CAGGGAGGGG GCGAGGCGCG GGCGTATGCC GTTGGCCGAA AGTACGGCGC GCACGGACGC 10260

CTCGAGGGCC CGGCGGGCGT CCTGGATCGC GCCGTGCGCG GCGTCCGCGT CCCCGGGGTC 10320

CACGTTGAAC AGCCCCCAGA ACGCAGCCCC GGTGCCGCCG CAGACCGCAA ACTTCACCGA 10380

GCTGGCCGTC TGCTCGATCT GCAGGCAGAC GGCGGCCATG ACCCCGCCGA GCAGCTGCCG 10440 GAGCGCGGGG CAGGCGTCGC ACGCGTCCGG CACCAGGCGC TCCAGCACGG CCCGGGCCCA 10500

GGGCTCCGAG GGGGCGGCCG CCACCAGCGC GTCCAGCCTT TCCAGGCCCG CCCGCCCCCG 10560

GGCTTCCGGC AGCCCGGCCT CCCCGAGGCC CGCGAGGGCG GCCAGGAGCT GGGCCTGGAG 10620

CCCGGAGAAA CAAAACCGCG CCGTCCAGAC CGGCCCGACG GCCGCCGGGG GGTCGAGTAG 10680

TTGGATGGTG GTGGCCGTGG GGTGCCACCG CGCCACCGCT TCCCGAAAGG CGGGCAGGAG 10740 GCGGCCGGCC GCCTCCGAGG CCACGGCCGG CCATGCCCGC GGGGGCAGGA CGACCCTGGC 10800

GCCCACCGCG GGCCAGGCCC CCAGGCACGC GGCATGGGTG GCCGCGGCGC CCCGCACCAG 10860

GTCACGCGCC GACTCGGCGG CGGCGGCGGC CGGCACGGTA AACGTGGGCC AGCCCGGAAA 10920

TCCCAGCACG GCAAAGTATT GGACGGGCCC TCCCCGGACC TCAAACCCGG GCCCCAGAAA 10980

AGCGAAGACG GGGGCCAGGG CTCCGGGGGC GGCGTGGACC GTGGTATGCC ACTGCCGGAA 11040 GAGGGCGACC AGCGCCGGGG CGGAGAACCC GTCGCCGGCG CTCACGAAGT AGTCGTAGCC 11100

GCGCGGCAGC AGCACCCGCG CCGTGACCCG CTGCGGGTGT CCGCGGGGCC GCAGGCCTAC 11160

CTCGCACACC TCGACCAGGT CCGCGAAGGC GCCCTCCTTG CTGGTCGGCG GAAACGCCAG 11220

GGTGGTGTAT TCGCGCGCGA AACGCGCGGT CCTCGTCGTG ATGGTGACGG CGAGCGAGGC 11280

GGAGGACGCG CACTGGGGGC TGTCGCGAAT GGCGGCCAGG CGCGCCCACG CCAACCGCGC 11340 GCCGGGGTGC TCGGCGACGC GCGCGGCCAG GGCCAGCGGG TCGACGTCGA CCTTGGCCTC 11400

CACGTCCAGG AGGGCGGCGC GAGGAGCGGC CGGCGGGCCC CACGACGCCC TTTCGACCCT 11460

CACGACCAGA CCCGTCTGCG GGTCCCAGCC CAGGCGCAGC GGGACGAAGA GGGCCACCGG 11520

CCCCGTCTGG CGCTCCAGGG CCGCCAGAAC GCACGCATAC AGCGCCCGCC ACAGGGTCGG 11580 GTCCCCCAGG GGCTCCAGCG GGGAGGCGGC CGGGGCGGCG CGGGCGGCCG CGACGGCCCG 11640

GCGGCCGAGA CGTCGGGGGA GCCGTAGAAG TCCTGCAGGT CGGACGAACC AACGGACACC 11700

TCCGCAAAGC GCGCGCGCGC CTCCCCCGCG GCGTCGCGAC AGACCAGATA CAGCAGGGCG 11760

TGGAGGCAGT CGCGCGTGCG CGGGGGCAGC CATACCGCGT ATAGGGTAAT GGCGCTGACG 11820 CTCTCCTCCA CCCAAACGAT GCCGGGGGCT TCCATGCCAC GACGCCCGGG GGTTGCCGTG 11880

TATCGAACGA GCGCGGCCCC AGACTTATAG GGTGCTAAAG TTCACCGCCC CCTGCATCAT 11940

GGGCCAGGCC TCGGTGGGAA GCTCCGACAG AGCCGCCTCG AGAATGATGT CAGTGTTGGG 12000

CTGGGCGCCG GAGGCGTGCG TGCGCAAGCA GCGCCCCCAC GCGGGCGCGC GCAGCTTGAA 12060

GCGCGCGCCC GCAAACTCCC GCTTATGGGC CATCAGCAGC GCGTACAGCT GTCTGTGCGT 12120 CCGGCAGGCG CTGTGGTCGA TGCGGTGGGC GTCCAGCAGC TCCACGATGG CTCGCTTGGT 12180

GAGGTTTTTA ACGCGCCCCG CCCCGGGAAA CGTCTGCGTG CTCTTGGCCA GCTGCACCCC 12240

GAACAGTTCG CCCCAGATGA TCTTGAACAG CGACAGCGCG TGCTCCGTCT CGCTCACGGA 12300

CCCGCGCGGG GGGCAGCCGC TCAGGGCGTC GGCCACGCGC TTAACCGCGT CCTCCGACAG 12360

CAAGGGGCCG TCGGTCACGT TACAGTGGCC CAGTTCGAAC ACCAGCTGCA TGTAGCGGTC 12420 GTAGTGGGGG TTCAGCAGCT CCAGCACGTC CTCGGGGCTA AAGGTTCGCC CCGACCCCCC 12480

GGCCATCGAG TCCCACTGCA GGCACGCGGC CATGGTGCTG CACAGACGGA ACAGCTCCCA 12540

GACGGGGGCG ACGTTTAGGG TGGGGTGTAG GGCCACAAGC TCCAGCTCTC CGGCGGCGTT 12600

GATCGTGGGG ATGACGCCCG TGGCGTAGTG GTCGTAAAGC CGCCGGAAGA TGGCGCTGCT 12660

ATGGGCGGCC ATGGGGACGC GAAGACAGGC CTCCAGCAGC ACCAGGTAGA TGAACCGCGT 12720 GCGGCCGACC AGGCTGTTGA GGCCGCGCAT GAGCGCGACC ACCTCGGCCG GCGCGACGTC 12780

CGGCCGGAGG TACTTTTCGA CGAAAAGGCC CACCTCCTCC GTCTCGGCGG CCTGGGCCGA 12840

CAGGGACGTG TCGGGGTCCT GGCAGCGCAG CTCCCGCAGA TCCCGCTGGG CCCTCAGGGC 12900

ATCAAAATGT ATCCCCCGCA AAAACAGACA AAAGTTCCTC GGGGTCAGCG CGGCGTCGTG 12960

GCCCCAGAAC CGCACGTGCA TGCAGTTGAG GGTCAGAAGC ATGTGGAGGA TGTTAAGACT 13020 GTCCGCGAGG CACGCCAGCG TGCACCTCTC GAAGTAGTGC TTGTACCGGA ATTTGCTGTA 13080

GATGCGCGAC CCCCGCGCCT GCGCCGCGTC GGCGTGCGAC GCGTCGCAGC GCCCTTTGAA 13140

CCGGCGGCAC AACAGGTTCG TCACCTGGGA AAACTGTGCC GGCCACTGCC CGCTGGCGCT 13200

CACCACGTGG TTGAGCAGCA TGGGCGTAAA GACGGGCTCC GAGCGCGCCC CGGACCCGTC 13260

CATGTAGATC AGCAGCTCCC CCTTGCGGAG AGTCCGTACC CGCCCCAGCG ACTGGTACAC 13320 GGACACCATG TCCGGCCCGT AGTTCATGGG TTTCACGTAG GCGAACATGC TGTCAAAGTG 13380

CGGCGGATCG AAGCTAAGGC CCACCGTCAC GACCGTTGTG TAGATGACCA CCCGGTACCG 13440

GCCCCATGTG GTCACGTCGC CGGGCGGGGT GAGCGAGTGG AGCAGCAGCA CGCGGTCCGT 13500

AAACTGCCGG CAGAACCTGG CAACGACCTC CGCGAAGGAG ACCGTCGACG AGAAGATGCA 13560

GACGTTATCT CCGCCGGCCA GGCGCGCCTC CAGCTCCCCG AAGAAGGTGG CGTCCGGGGG 13620 GGCGTCCGGG GGGGGCGCCC CGCCCGCCGG CCCCGGCGGG CGCAGGGCCG CCTGCAGGAC 13680

CTCGGGCCCC AGGCGCGGGA GAAACAGACA ACGGCGCGCC GAAAATCCGG GCATGGCATA 13740

CTCCCCGATG ACCACGTGAA CGTTCTTTTC GCCCCGGAGG CTGCACAGAA AGTCCACCAG 13800

CTGCGCGTTG GCGGTGGCGT CCATGGCGAT GATCCGCGGG CACGTGCGCA GCAGGCGCAG 13860

CATCAACGCG TCGACGCGGC CCAGCTGCTG CATCGTCGGC GAGTACAGTT GGCCCAACGT 13920 CGACATGACT TCGTCCAGGA CGAGCACGTC GTAGTTGTTC AACAGGTTCG GGCCCACGCG 13980

ATGAAGACTT TCCACCTGCA CGATGAGACG GTGGAAGGGG CGGTCGTTCA TGATGTAATT 14040

GGTGGATGAG AAGTAGGTGA CGAAGTCGGG CAACCCTGAC TCAGCGAACC GCGTCGCCAG 14100

GGTCTGAGTA AAACTCCGAC GACAGGAGAC GACCAGCACA CTCGTGTCCG GAGAGTGGAT 14160 CGCTTCCCCC AACCAGCGGA TCAGCGCGGT AGTTTTTCCC GAGCCCATTG GCGCGCGGAC 14220

CACAGTTACG CACCGGGCCG TCGGGGCGCT CGCGTCCGGG AAGGTGACGG GTCCGTGTTG 14280

CTGCCGCTCG ATCGTTGTTT TCGGGTGGAC CCGGGGAACC CACTCGGCCA AATCCCCCCC 14340

GTAAAGCATC CGCGCCAGCG ATACACTCGA CGTGTACTGC TCGCACTCGT CATCCCCGAT 14400 GGGACGCCGG GCCCCCAGGG GATCCCCCGA GGCCGCGCCG GGCGCCGACG TCGCGCCCGG 14460

GGCGCGGGCG GCGTGGTGGG TCTGGTGTGT GCAGGTGGCG ACGTTCATCG TCTCGGCCAT 14520

CTGCGTCGTG GGGCTCCTGG TGCTGGCCTC TGTGTTCCGG GACAGGTTTC CCTGCCTTTA 14580

CGCCCCCGCG ACCTCTTATG CGGAGGCGAA CGCCACGGTC GAGGTGCGCG GGGGTGTAGC 14640

CGTCCCCCTC CGGTTGGACA CGCAGAGCCT GCTGGCCACG TACGCAATTA CGTCTACGCT 14700 GTTGCTGGCG GCGGCCGTGT ACGCCGCGGT GGGCGCGGTG ACCTCGCGCT ACGAGCGCGC 14760

GCTGGATGCG GCCCGTCGCC TGGCGGCGGC CCGTATGGCG ATGCCACACG CCACGCTAAT 14820

CGCCGGAAAC GTCTGCGCGT GGCTGTTGCA GATCACAGTC CTGCTGCTGG CCCACCGCAT 14880

CAGCCAGCTG GCCCACCTTA TCTACGTCCT GCACTTTGCG TGCCTCGTGT ATCTCGCGGC 14940

CCATTTTTGC ACCAGGGGGG TCCTGAGCGG GACGTACCTG CGTCAGGTTC ACGGCCTGAT 15000 TGACCCGGCG CCGACGCACC ATCGTATCGT CGGTCCGGTG CGGGCAGTAA TGACAAACGC 15060

CTTATTACTG GGCACCCTCC TGTGCACGGC CGCCGCCGCG GTCTCGTTGA ACACGATCGC 15120

CGCCCTCAAC TTCAACTTTT CCGCCCCGAG CATGCTCATC TGCCTGACGA CGCTGTTCGC 15180

CCTGCTTGTC GTGTCGCTGT TGTTGGTGGT CGAGGGGGTG CTGTGTCACT ACGTGCGCGT 15240

GTTGGTGGGC CCCCACCTCG GGGCCATCGC CGCCACCGGC ATCGTCGGCC TGGCCTGCGA 15300 GCACTACCAC ACCGGTGGCT ACTACGTGGT GGAGCAGCAG TGGCCGGGGG CCCAGACGGG 15360

AGTCCGCGTC GCCCTGGCGC TCGTCGCCGC CTTTGCCCTC GCCATGGCCG TGCTTCGGTG 15420

CACGCGCGCC TACCTGTATC ACCGGCGACA CCACACTAAA TTTTTCGTGC GCATGCGCGA 15480

CACCCGGCAC CGCGCCCATT CGGCGCTTCG ACGCGTACGC AGCTCCATGC GCGGTTCTAG 15540

GCGTGGCGGG CCGCCCGGAG ACCCGGGCTA CGCGGAAACC CCCTACGCGA GCGTGTCCCA 15600 CCACGCCGAG ATCGACCGGT ATGGGGATTC CGACGGGGAC CCGATCTACG ACGAAGTGGC 15660

CCCCGACCAC GAGGCCGAGC TCTACGCCCG AGTGCAACGC CCCGGGCCTG TGCCCGACGC 15720

CGAGCCCATT TACGACACCG TGGAGGGGTA TGCGCCAAGG TCCGCGGGGG AGCCGGTGTA 15780

CAGCACCGTT CGGCGATGGT AGCCGTTTCG TTCGTTTTAA TAAACCGACG TTGTGCGTTT 15840

CACCATACTT CGGCGCGCGC GTGTGTGTGT TTTTTTTGTG GTGTTTATTT TCCCCCACCC 15900 CTTCCTTTTC TTTCGGCCAC CACCCCCCTC CTCCCCCGTA CTATACAACA AAAAATACCA 15960

CACATACGAC CAAATACGGA CAATCATTTC TGTCTTTATT CGCTGTCAGA GAGTGGGGGC 16020

GTGAGCGTGG CAGGAGGGCG GGCCACGTCG GGGTCCCGCC GTCTGGTGTG ACGCGATGGG 16080

GGGTCCGATG CGCGCCGGTA CTGGGGCCCC GGCGCCCGGG TGACCACGCG CATGTCGGGG 16140

GGCACGTAGA AGTTACCCTC TTCTTCGGAC TCGATGTCCA CGACGTCAAA TTCGTGGGCG 16200 GTCAGCGAGA CGACCTCCCC GCCGTCGGTG ATGATGACGT TGTGTCGGCA GCAGCAGGGC 16260

CGCGCCCCGG AGAACGCGAG GCCCATAACT TGGCGAGCGT ATCGTCGAAG GCCAGGCGGC 16320

TGTTTCGCCG GATGTCCCGG TAGATCCCCG GCTCGACGCG GACGGGGGTG ATGATCAGGG 16380

CGATCGGAAC GGCCTGGTCC GGGAGGATCG ATGCCTTGGC GGGTCCGGGG GCCCCGCCAC 16440

GCCCGGCGGG CGCTCCGCGG CCGTCCTCCA GGCGGAACGT CACGCCCTCC TCCGCGCCCG 16500 CGCGGTGCCT GCCGAGGAAC GTCACCAGGT GCGGTTGCAG GGGGCAGTCG GGAAAGTGGC 16560

TGTCGAGGAC GTATCCCTGC ACCAAGATCT GTTTGAAGTT CGGGTGGCGG GGGTTGGCGA 16620

AGATGGGCTC GCGGCGAACC AGCTCCCCGG AGCTCCAGGC CACGGGAGAG ATGGTGCGAC 16680

GCTCGAGGTC GGGGACGCCA AACAGAAGCA CCTCCGAGAC AACGCCGCTA TTTAACTCCA 16740 CCAGCGCCCG ATCCGGGGCG GAGCATCGCC TTTTTTCGCC GGCGGCGCGG GAATCGAGCC 16800

AGTCCCGGTC TTGGGTGACG AGCGCCTCCT CCGGGCCCGG GACGCGCCCG GGCGCGAAGT 16860

AGCGCACGCC GGGGTTGGGG ATGGACCGGA TGAACGCCCG GAACGCCTCC GGCGATCGCC 16920

GCGCCATCAG GTCCTCGTAC GCGGAGGCCG CGGGGGCGCC GGGGTCCGCG GGGTCGAACG 16980 CGTACTTGGC TCGGCACTTA ACCTCGTAGA AGGCCAGGGG GGTCTGGGGG GCGGGGGCCA 17040

GGTAGCCGTG AGGGTCCCTG GGGCACACGA GGATGTCCAG GGACGCCCCC ACCATGCCCG 17100

TGTGGCCGTC CATGAGGACC CCGCACGCGT GCACGTTCTC CTCGGCGAGG TCCCCGGGTT 17160

GGTGAAAGAC GAAGCGCCCG GCGTCGGCGT CGTCGTTGAC GCCCGCGTCC GCGCGGCCCA 17220

CGCAGTAGCG AAACAGCAGG TTTCGGGCCG TCGGCTCGTT CACCCGCCCG AACATCACCG 17280 CCGACGACTG GGCGTCCAGC CGCAGGCTGG CGTTGTGGGT GAGCCACTGG GACGAGAAGC 17340

ACGGACCCTG CGCGCCCCAC CGCAGCGTGG AGGCGGTCGT CAGGCCCCGC CGAAGCAGGG 17400

CCCAGAGCTG GCAGTCGGCC TGGTTTTGCG TCGCCGCCTC GTAAAATCCC ATAAGCGGGC 17460

GGGGGGCGAC GGCTTCGGCG GCGGACGGGG GGGCGCGGCG CGTCAGGCGC CAGAGGTGCC 17520

GGCCGAGCCC GCGGTCCACC ATGCCGGCCG CCTCCAGCGA CACGACGAGG GAGCACAGAT 17580 AGTCCAGGCG AGCCCACAGG GGCCCGATGG CCAGAGGGGA GCGGACGCCG CGCAGCAGGC 17640

CGCGCAGGTG GCGCTCGAAC GTTTCCGCCA AGATATGGGG GGGCAGTGCG TTGGGGATCG 17700

CCGACGCCGA CCACATCGGG TCGGGGTCCG GGGGACCGGG GCTGCAGTCC GGGTCGATGG 17760

CGTGTGCGCC CCCCGGCGAG AGGGGAATGT CGGGGGTTGG CGGGCCGGAT GAGGCCTCAG 17820

AGAGGGCCGG GGACGCGGGC CGGGCCTTTT CGCCCGGGGC CCCGCCGTCG GGTTGCCCAC 17880 GTGGGGGGCT CTGGGGCCAA TGGGAACCCG GGGCCCCCGG TGACGTGGGG CGGGGTGGGG 17940

CGGGGCGGGG CCCAAAGACG GTCGCCAGAT CTAGGCTGTT GGGTCGGGGC CGCTTCGGGG 18000

GACTATCGGG GTCGCGGGCG GGGTCCGCGG GGCGCTTGGC GCCGGGTGTT GCGGCGGCCG 18060

CCATTTTTAC GAGCAGCCGA AGAGCTCGAG GGCGGAAGGG ATCCTCACGA CAGAGAGTGG 18120

CGCGCGGCCG GGTTGGCGTG ACAGAGGCGG GAGACCAGCA CCAGCAGCGG CCTCAGCTCG 18180 GGCGGCAGCG ACACCGACGA CAGGACGGCC TTGTGCGTGC GCTGGTAATT TATACACTGC 18240

TCCGTGAACG CGCGCCGAAT CTTGGGATTG CGAAGGTGGC GCCGGATGCC CTCCGGCACG 18300

TCATACGCCA GGCCGTGGGT GTTGGTCTCG GCCGAGTTGA CAAAGAGGGC GGGGTGCAGA 18360

ACGCAGCGAT AGGCGAGGAG GGCCACGGCA AAGTCCGGCG AGAGCTGGTT GTTAAAGTAC 18420

TGGTAGCCCG GGACGCGGGT CACGGGGACG CCCAGGCTCG GGGCCACGTA CACGCTAACC 18480 AGCAGCTCCA GCAGCGTCTG CCCCAGGGCG TAGAGATCGA CCGCCAGCCC GACGTCGTGC 18540

TTCAGGGGGC GGTTGTTAAA CTCGGCCCGC TCGTTGTTGA GGTACTTTAC CAAGAGCTCC 18600

GGCGGCTGGT TGTACCCGTG CCCCACCAGA GTGTGAAAGT TGGCCGTGGT CAGGGCGGCG 18660

GGCATCCCAA ACCCCCGGGG GGACTCGAGG TCCGGCTCCT GGAGGCAAAA CTGGCCCCGG 18720

GATATCGTGG AGTTGGAGTT CAGGGTCACC AGGCTAAAGT CGGCCAGGAC GGCCCGCCGG 18780 AGCGACACCG CGTCCGATCG CAGCATCACG AGGACGTTGG CGCACTTGAT GTCCAGGTGG 18840

CTGATCCCGC ACCTGGTGTT CAGGAACACC ACGGCGCGCG CCAGGTCTGT GAAGCAGTGG 18900

TGGAGGGCCG TCGCGACGGA GGGGGTGGTC GCGCGCAGGG ACGCCAGCTG GCCGATGTAC 18960

TTGCCGAGGT CCATGTCGTA CGCGGGGAAC ACGATCTGGC GCTGCTGCAG CGAGAACCCG 19020

AGCGGGGTGA TAAAGCCGCG GATGTCGTGG GTGCGGCCGC CGCGAAGAGC GCACTCCCCC 19080 ACGAGCAGGG TCGCGACGAG CTCCACGGCA AACCACTCCT TTTCCCGGAT GGTCTTCACG 19140

GCGAGCTTGT GTTCGCGAAT CAACTGCACC TCGCCGTACC CCCCCGAGCC CCCGAAGCTG 19200

CGGGCCCCGG GGATCTCCAG GGTCGTGTAG CGGAGGGCGG GGTTGACGGC GAATACGGGG 19260

ATGCATAGCT TGTGGATGCG CGCGAGGGAC AGGATGTGCG AGGGGGGCGA CGGGGGCGAG 19320 GTCATGGCCG TCTCGGACCT GCGCAGGGGC GGGCGCCTCA GCTTGGCCGC AGGGCCGGGG 19380

GCCTCGGGGG ACGAGCGGCG ACGAGACGAG CGGCTCACTC GCCATCGGGA CAGTCCCGCG 19440

CGAAGCCGCT CCCGGAAGCT GGATCGGCGG CGGGACCCGG GGCGGGCTCC GGAGACGGCG 19500

CCGTCTCGGG GGGAGGGGCC GCTTGGGCGT CCGGACGCCC GGCGGCTGAG GGAGTGTATG 19560 TAGGACGCGA GCCAGGCCTT GAAGGAGCGT CGGTGTGCAC CTTGGGGGCT GATGTCAGCT 19620

GCCACATGAC TAGCAGGTCG CTGTCGCCCG GACTCATCCA TCCGTCCGCC AGGTCGCCGT 19680

CCCCCCACAG AGACGCGTTC GCCGCGGCCT CTTCGAGCTG CTCCTCCTGG TCCGCAAGAC 19740

GATCGTCCGC CGCGTCCAGG CGCTCGCTAA GCGCGGGATC GAGGTACCGT CGGTGTGCGG 19800

TTAGAAAATC ACGTCGCGCC GCTTGCTCTT CCACGCGAAT TTTAACACAG GTCGCTCGCT 19860 GTCGCATCAT CTCTAAGCGC GCGCGGGACT TTAGCCGCGC CTCCAATTCC AAGTGGGCCG 19920

CCTTGGCGGC CATAAAGGCG CCAACAAACC TAGGATCTTG TGTACTCACG CCCTCCCGGT 19980

GTAGCTGCAG GGTCTGGTCC CTGTACACCT CGGCCCGGAG GTGCGTCTCG GCCAAACGTC 20040

GGCGCAGGGC CGCGTGGCTG GCGTCTCGGC TCATCTCGCC GCCCCCGCGC GCGCCCGACG 20100

TCGGACTCCT TCGCCCCGAC CCCCCTGACC TCAGCCGCCC CCGCCTCGCC CGCGATGTTT 20160 GGCCAGCAGC TGGCGTCCGA CGTGCAGCAG TACCTGGAGC GCCTGGAGAA ACAGAGGCAA 20220

CAGAAGGTGG GCGTCGACGA GGCGTCGGCG GGCCTGACGC TCGGCGGCGA TGCGCTGCGC 20280

GTCCCTTTTT TGGATTTTGC CACCGCGACG CCCAAGCGCC ACCAGACCGT GGTCCCGGGC 20340

GTCGGGACGC TCCACGACTG CTGCGAGCAC TCGCCGCTCT TCTCGGCCGT CGCGCGGCGG 20400

TTGCTGTTTA ATAGCCTGGT GCCGGCGCAA CTCAGGGGGC GTGACTTTGG GGGCGACCAC 20460 ACGGCCAAGC TGGAGTTCCT GGCCCCCGAG CTGGTGCGGG CGGTGGCGCG CCTGCGGTTT 20520

CGGGAGTGCG CGCCGGAGGA CGCCGTGCCC CAACGCAACG CCTACTACAG CGTCCTGAAC 20580

ACGTTTCAGG CCCTGCACCG CTCCGAAGCC TTTCGGCAGT TGGTTCACTT CGTGCGGGAC 20640

TTCGCCCAGT TGTTGAAAAC CTCGTTCCGG GCCTCTAGTC TCGCGGAGAC TACGGGCCCC 20700

CCGAAGAAAC GGGCCAAGGT GGACGTGGCC ACCCACGGGC AGACGTACGG CACCTTGGAG 20760 CTCTTCCAGA AAATGATACT AATGCACGCG ACCTACTTTC TGGCCGCCGT GCTGCTCGGG 20820

GACCACGCGG AGCAGGTCAA CACGTTCCTG CGGCTCGTGT TCGAGATCCC CCTGTTTAGC 20880

GACACGGCCG TGCGGCACTT CCGCCAGCGC GCCACCGTGT TTCTAGTCCC CAGGCGCCAC 20940

GGAAAGACCT GGTTTTTGGT GCCCCTCATC GCGCTGTCGC TCGCGTCCTT CCGGGGGATC 21000

AAGATAGGCT ACACGGCCCA CATCCGCAAG GCGACCGAGC CCGTGTTTGA TGAGATCGAC 21060 GCCTGCCTGC GGGGCTGGTT TGGCTCGTCC CGGGTGGACC ACGTCAAGGG GGAAACCATC 21120

TCGTTCTCGT TCCCGGACGG CTCGCGCAGC ACGATCGTGT TTGCCTCCAG CCACAACACG 21180

AACGTAAGTA CGCCTTCCTC CCGCGGTGCC TGTTTCCCCG GTGCCGCCCT CCCCGAGATC 21240

GACCGACAGA CAAACACAGC CAGACGCGAG TGTGGGACGA CACGCCCGCA GCCCCCCCCG 21300

CCATGGCGGG GGGAAGCCTT ACTGTTTATT TGTAATCGGA CGATGAGGCT CTGGCCACGG 21360 CCCGCGCGAC CGCGGGGCAG CTCGTTGCAA ACAGGCGGCT GGTATACGAT GACAGAACGC 21420

AGAGGCGCCA CCCGGCGCTG GTCGGGCGGA TGACGCTTTC CGCGCCGTCC CGGCCCACGA 21480

CGACCTCGTG CAGGTGGGCC GTGATGCGCG GGCGGCGGGT CGCCTGCCGC AGGATAACCG 21540

CGTCCACGGG GTGCCCGAAG AGGAGCTGAC ACAGGCTCGC GTCCCCCCGG ACGGCCAGGG 21600

TGCGCTGGGC CATATTGGAC CACATGCACG GGGCGACGCA GGGACAGGCC TCCGCCACGG 21660 CGGGGGCGCG CCACAGCGCG TTGGCGGAAT CGATGTGGGC CGTCGGGGCG CAGGCGCCGC 21720

CTCCTCCCGG GGGGTCGGTA ATCCTGGATA GCAGCCATCC TAAATGGCGG GCCCGGCTGC 21780

CCGGGGGACA GAGCGACCCC AGGTCATCAT CCATGGCCCA GCAGTATATG CGGCCGCCGG 21840

GGAGGTGCCA CCAGGCCCCC GGACCCAGGG CACAGCACGC CCCCGGATTC GGGGGCGGTT 21900 CCGTGGGTAC CAGGTAGGCG CCGTCGAGCT CGTGGGCCAC GGGCTCGTCC GCGAGCTGTT 21960

CGGCGGCGGG GTCGGGGGTT TCCTCCGGGG GGGAGGCAGC TTCCAGGTGG CCGAAGGCTA 22020

GGGTGCACAG CAGCGGGGTC CGGGGGTGCG TTACGCTGCG GAGGTGGACG GTGGCGCAGT 22080

AGCGGCGCTC GCGGTTAAAG AAGAAAATGG CAAAGAACGT GTTCGAAGGC AGGCGCAGCG 22140 CCTTGGGCCG CGTCAGGTAC AGGAAGATCT CGCAGAAAAG GGCACGCTCG GGGTCGGGGT 22200

CCGGAAGGGC CACCTGGCAC AGCGGCTCGG TGAGGACCGT GAGGCACCGA AAAATCTTAA 22260

GCCGCTCGTC CCCCCGAACG ACGCGCCACA CGAAGACAGA GTTGGCGATG CGCGCGACGA 22320

GGTCGGCTTC GGGCCCCGGG TCGGGGGCGC GCGCGTCGGG GGGGGCGCCC CGGTGACCCG 22380

GCGGGGCCGC GGCTCCCGGG GGGCCTGGCG TCGCCTGGGG ACGCCAGAGT GCCCGCTGTG 22440 CCAGGTTGGT GGTGGGGAAG GGACCGGAGA CGCACCAAAA GCAGAGGGGC CAGCGCGTGT 22500

ATGAGTTGGG GGGGGGGTGG GTGAGCGGTG GAACAAAAGC ACGCGTCAGC GGACAAGGCC 22560

GGGTCCCGTA GCCGCCCCGC GACAGAACCG GAGTCCGACG GCACGCGCGA CGGGGTCTGC 22620

GAGGCTGAGG TACGCCGCGG TGTTAATGGT AAACGCAAAG CCTCCCGGAA AGACCACTAG 22680

CCCGCAGAGG CGGCGATTGA ACCCAAGGCA GAGGTACGCG TAGCTCTCTC CCGGAAGGTA 22740 TTGCTCGCAG ACCCTGTGCG GGGCAGTGGA GGGGCTGCCC TCCATGAAGC GACATTTACT 22800

CTGCTCGCGT CCATTGACGT CACCGTCAAT CACCACTGCG ATTGGACGGT TGGTAAGGCG 22860

CAGCGTGTCT CCGCTGGTGC TGTAGTAGTC AAACGCGTAG TGGGCGTCGG AGTCGGCGAA 22920

GCGGGCGGGG ATGTCGTCGC TGAGAGGGAC GAGCCGCCGC CGCCGCCCCC GACCGCCCTG 22980

GCCGCCCAGA TGCGCCAGCA CGGCCAGGGC GTACGCGGTG TGAAAGAACG CGTCGGGGGC 23040 GGTCCCCTCG AGGGCGCGCA TCAGGTTCTC CAGGAGCACG GGGAAGCGCC GCGTCACCTC 23100

CCCTAGCCAC TCGCTCTGGT GGGGGCCAAA GTCGTAGCGC AGGCGCTGGA AGATGCGCGG 23160

GCCGCCTTGG AGCGCGGCCC GGATAGAGTG GCCCAGGGCC CGCAGACACG CGATCTGGAT 23220

GCGCGCGACG AAGGCCACCT CGGCCGCGAT GTCAAAGGGC TGCAGCACGG GGCGCGGGTG 23280

GCGCAGGGGT CCCTCGAGCG CGGGAAAGCG ACGCAGCAGC GCCGTCTGGG CCGCGGGGGA 23340 CAGCTGGTGG GGGCGCACGA CGCGCTCGGC GGCACAGGCC TCCGTCAGGG CCGTGGCCAG 23400

CTCGGAGGAC AGCCGCGGGG GGCGGGCGCG TCGCCCGCCC CACGCCACCG AATTCTCGTA 23460

GGAGACGACG ACGAAGCGCT GCTTGGTCCC GTAGTGATGG CGCAGGACCA CGGAGATGGA 23520

GCGACGGCTC CACAGCCAGT CGGGCCGGTC GCCGCCGGCC AGAGCTTCCC ACCCGCGGTC 23580

CAGCCACTCG ACCAGCGATC GCGGCTTGGC GGTCCCCGGC ACGAGGGTGA GCACGTCGTT 23640 GAGGACGTCC TCGCCCGCGG CCCGGGGGCC CCCCGGGGTG GCAAAGCGCC CCCCGCCGGG 23700

CGGCTCCAGG CCCGCCAGCA CCGCCTCCGC GTCCGACGCG CCCAGGGCTC CCCCGCTGAC 23760

GGCCTGGTGG ACCAGGGCGC CCTGGCGGAG CCCCGAGGCG ACGCCGGAGG CCGCGTGCTT 23820

GGGGCGCGCG CGGACCGGGT GGCGGCGGGT GACGTCCTGC ACGGCCCGCT GGACCAGCGC 23880

GAGGATCTCC TCGTTCTCTT GCGTGATGGA CACGTCCTCC GCGGTGGCCG TGTCGCCTCC 23940 CGGGGCCGTG AGCTGCTCCT CCGGGGAGAT GGGGGGGTCT GGGGTGCCGA CAACGGCCGG 24000

CCCGGCCCCG CCCGAGACCG AGGACGCCTG GGGAGTGGGG GTGCCGCTTT CCCCCATCCC 24060

CAGGGACAGG TGGGCCGCCG CCTCCGTCGC GGCGGCGGGA GCCGCGGCCC CCAGCCGCGC 24120

GACGTAGCGA CAAAAGTGGC GACAGAGGCG CATGAGGCGC GCGCCGTCGG CCGCGTATCG 24180

CGTGTTTGGC GGGACGAGCT CGTCGTAACT GAACAGGAGC ACGCGGGCGC AGGTCGCCCA 24240 CGGGCCCCAC GCCAGGCGCA GCGCCGCGAC CGTGTACGGG TCGTACACGC CTTGGGCGTC 24300

GCACGCGACC GGCAGGGAGA CGAACAGCCC GCCCGCGCTG GGGACGCGCG GCAGGAGGTC 24360

CGGGTGCGCC GGGATGACGG GGGCTAGGAT CGCCCCCACC GCATCCGCCG GCACGTAGGC 24420

GGCAAACGCC GAACGCCACG GGGTGCAGTC GCCGGTCGCG TGGGCCCGGG TCTGGGTTTC 24480 GACCCGGAAG TTCGCGGCCG CCCCGCCGTC GGGGCGGCCG CGCACGAGGG CGGACAGCGG 24540

GACCCCCGCC GCCGCCAGGC ACTCGCTGGA GATGATGACG TGAATCAGCG AGGCGGGGCT 24600

GCTCGGGTCC CGGGTGAGAT CGTATTGGAC CTCGTTGGCA AAGTGCGCGT TCATGGCCCG 24660

GCCGGCGGTG CGAGCCCTTC CCGGTGCCGG AAGGGGCGTG GGTGGGGGGT GCGTGTGCGC 24720 GTCCTCGGGG CCCGCGGGCG CACGTGCGCT TATACGCTGT GTGTTTCGTC TGTCCCCAGG 24780

GAATCCGGGG CCAGGACTTT AACCTGCTTT TCGTCGACGA GGCCAACTTT ATTCGCCCGG 24840

ATGCGGTCCA GACGATTATG GGCTTTCTCA ATCAGGCCAA CTGCAAGATC ATCTTCGTCT 24900

CGTCGACCAA CACCGGGAAG GCCAGCACGA GCTTTTTGTA CAACCTCCGC GGGGCCGCCG 24960

ACGAGCTGCT CAACGTGGTC ACCTATATAT GCGACGACCA CATGCCGCGG GTGGTGACGC 25020 ACACCAACGC CACGGCCTGT TCCTGCTATA TCCTGAACAA ACCCGTGTTT ATCACGATGG 25080

ACGGCGCCGT TCGCCGGACG GCCGATCTGT TTCTGCCCGA CTCCTTCATG CAGGAGATCA 25140

TCGGGGGGCA GGCCCGCGAG ACCGGCGACG ACCGGCCCGT CCTAACAAAG TCGGCGGGGG 25200

AGCGGTTTCT GCTGTACCGC CCCTCCACCA CCACCAACAG CGGCCTGATG GCCCCCGAGC 25260

TGTACGTGTA CGTGGACCCG GCGTTCACGG CCAACACGCG CGCCTCCGGC ACCGGCATCG 25320 CGGTCGTCGG GAGGTACCGC GACGATTTCA TTATCTTCGC CCTGGAGCAC TTTTTCCTCC 25380

GCGCGCTCAC GGGATCGGCC CCCGCGGACA TCGCCCGCTG CGTCGTGCAC AGCCTCGCCC 25440

AGGTGCTGGC GCTGCACCCC GGGGCGTTTC GCAGCGTTCG CGTGGCGGTC GAGGGCAACA 25500

GCAGCCAGGA CTCGGCCGTG GCCATCGCCA CACACGTGCA TACCGAGATG CACCGCATCC 25560

TGGCCTCGGC GGGGGCCAAC GGCCCGGGGC CCGAGCTCCT CTTCTATCAC TGCGAGCCGC 25620 CCGGCGGCGC GGTATTGTAC CCCTTCTTTC TGCTCAACAA ACAGAAGACG CCCGCCTTCG 25680

AATACTTTAT CAAAAAGTTC AACTCCGGGG GCGTCATGGC GTCCCAGGAG CTCGTCTCCG 25740

TGACGGTGCG CCTGCAGACC GACCCGGTCG AGTATCTGTC CGAGCAGCTC AACAACCTCA 25800

TCGAAACCGT CTCTCCCAAC ACCGACGTCC GCATGTACTC CGGAAAACGC AACGGTGCCG 25860

CGGACGACCT CATGGTCGCG GTCATCATGG CCATTTACCT GGCGGCCCCG ACCGGGATCC 25920 CCCCGGCCTT TTTTCCGATC ACGCGCACGT CTTGAGTCTT TCTTGCCGTT TCTTTTGTTT 25980

CTCTTTCTTT CCCCCCTCTC TCCGCAATAA ACGCCTTCCC GGAACTGTGT TTTCCCCCCC 26040

TACAACAGTG TTGTCCGTTG GTTGGGTGGT TGGGGTGCGG GGGTGGGCGG GGGAAGCAAG 26100

AAAACGGTCG GCGAACACAA CATCGGGAAA ACGGATTCCC GAACGTGCGT CTTCCCAGAT 26160

TCGACACACA CCCCCCTTCT CCTTAAATAA ACACAAACCA CACGCTCGTT GGTTGGTTAA 26220 TGCCGGCGCT TTATTTACGT CTTGTTTTTT TGCGTTTCCT CCGCGGGTCC CTTCCCAACA 26280

CGCCTGCCCC CGCCTCAGGG GTAGCGGATA ACCGGGGCCA TGTCGCCGGA TTGCACAACG 26340

GCGGCGCCGT CGAACGTACA CACCCGAACC GCCGGGGCCA GGGCCAGGAT GTCCCCGAGT 26400

TGGCCCGCGT GCGCCAGCCA GGCGACCAGC GCCTCGT AA GCGGCAGCCT GCGCTCGCCG 26460

TCCTGCATCA GCATGGGGGC TTCGGGGTGG ATGAGCTGGG CGGCTTCTCG CGTGACGCTC 26520 TGCATCTGCA GGAGCGCGTT CACGTATCCG TCCTGGGCGC TCAGCGCGAG CAGCCGGGGG 26580

ATGAGCGTGA GGATGAGGGT GGTTCCTTCG GTTATGGAGT AGACCATGTT GAGGACGAGC 26640

GACCGCAGCT CGGTGTTTAC GGAGGCGAGT TGCTGGACGT CGGCCACGAG CGAGAGACGG 26700

GCCCCGTTGT AATACAGCAC GTTGAGGTCG GGGAGCTCCC CGGGCGTCCG GGGGTCGGGG 26760

TTGAGGTCCC GGATGCCCCG GGCGACCAGC CGCGCGACTA TCTCGCGGGC CAGGGGCGTT 26820 GGGAGCGGGA CCGGAAACCG CAGCGTGAGG TCCAGCGACT CCAGGCGCAC GTCCGTCGCC 26880

TGGCCCTCGA AGACGGGCGG GACGAGGCTG ACGGGATCCC CGTTGCAGAG GTCGACGGGG 26940

GAGGTGTTGC GGAGATTGAC GGTGCCGGCG TGCGTGAGCC CCAGGTCCAC GGGGCAGGCG 27000

ACGATTCGCG TGGGCAGCAC CCGCGTGATT ACCGCGGGGA AGCGCCTGCG GTACGCCAGC 27060 AACAACCCCA ACGTGTCGGG ACTAACTCCT CCGGAGACGA ACGATTCGTG CGCCACGTCC 27120

GCGAGCGCCA GCTGGCGGCG GATGGTCGGC AGAAAGACCA CTCGACCCTC GCACCGCTGC 27180

AGCGCCGCGG CATCGGGGCG CGAGATACCC GAGGGGATCG CGATGTCTGC TTCGAAACAA 27240

TCCGTGATCA TGGCGCCGGG CCGCGAGACA CCGGAACGCG GGGGTGCGGG AGGGCCGGAA 27300 AGCGCAACGC AACCGGGACG ATGATGAAAC AGAGATGGGG GGCACCGACC GTGTGGGAGA 27360

GGGGGCGGGG CAGGGCTCAG CAGCACGCAC GGGGAGGTCT GTCGTGCGCA GGAGCCCCAG 27420

GTGAGAATCA GTCCCCCGGA GCTCGGGTCT GGGTTTTATT GGGACCTGCC CTCGGAATCG 27480

CGGCTCCCAG TCCAAGCCCC CCCGGGGGGG CGGGGACAGG GGGTGTGTGT GGGTAAAAGC 27540

AACGTCGGAA AATCAAACCC AATGCCCCAA ACAGGAAAAA AAAAAAAGAC GGGCGGGTGG 27600 AGGGAAAGCT GGGGAAGAAG AAGCCAATTT TACAGAGACA GGCCCTTTAG CGGGGAGGCG 27660

TCGTAGATGA GATACTGCGT AAAGTGGGTC TCTCGCGCGT GGGCCTCCCC ATCGCGGGCG 27720

CTGCGTAGCA GGGCGGGGTC GCTGGCGCAG GTGATCGGGT AGGCTTCCTG AAACAGGCCG 27780

CACGGGTCTT CCACGAGCTC GCGGCACCCC GGCGGGCGCT TAAACTGCAC GTCGCTGGCA 27840

GCGGTGGCCG TGGATACCGC CGATCCCGTT TCCACGATAA GACGCTCCAG GCAGCGATGT 27900 TTGGCCGTGA TGTCGGCCGC GGTGAAGAAC TTGAAGCAGG GGCTGAGGAC GGGCGAGGCC 27960

CCGTTGAGGT GATAGGCCCC GTTGTACAGC AGGTCCCCGT ACGAGAACCG CTGCGACGCC 28020

CACGGGTTGG CCGTGGCCGC GAAGGGCCGC GCCGGGTCGC TCTGGCCGTG GTCGTACATG 28080

AGGGCTATGA CGTCCCCCTC CTTGTCCCCC GCGTACACGC CGCCGGCCGC GCGTCCCCGC 28140

GGGTTGCAGG GCCGGCGAAA GTAGTTGATG TCCGTGGCCA CGGGGGTGGC GATGAACTCA 28200 CACACGGCAT CCTGCCCGTG GTCCATGCCG GCGCGCCGCG GCACCTGGGC GCAGCCAAAG 28260

ACCGGGAGGG GCTGGGCCGG CCCCAGCCGG TTTCCCGCCA CGACCGCGTT GCGCAGGTAC 28320

ACGGCGGCCG CGTTGTCTAG CAGCGGGGGG GCCCCGCGGC CGAGGTAAAA GTTTTGGGGG 28380

AGGTTGCCCA TGTCCGTAAC GGGGTTGCGG ACGGTGGCCG TGGCCGCGAC GGCGGTGTAG 28440

CCCACACCCA GGTCCACGTT TCCGCGCGGC TGGGTGAGCG TGAAGCTGAC CCCCCCGCCC 28500 GTTTCGTGGC GGGCCACCTG GAGCTGGCCC AGAAAGTACG CCTCCGACGC GCGCTCGGAA 28560

AACAGCACGT TCTCGGTCAC GAAGCGGTCC TGCCGCACGA CGGTGAACCC GAACCCGGGG 28620

TGGAGGCCCG TCTTGAGCTG GTGATACAGG GCCACGGGGC TCATCTTGAA GTACCCCGCC 28680

ATGAGCGCGT AGGTCAGCGC GTTCTCCCCC GCCGCGCTCT CGCGGGCGTG CTGCACCACG 28740

GGCTGGCGGA TGGAGGAGAA GTAGTTGGCC CCCAGGGCCG GGGGGACCAG GGGGACGTGG 28800 CGCGCCAGGT CGCGCAGGGC CGGGGGGAAG TTGGGCGCGT TGGCCACGTG GTCGGCGCCC 28860

GCAAACAGCG CGTGGACGGG CAGGACGTAG AAGTATTCGC CATTTTGGAT GGTGTGGTCC 28920

AGGTGCTGGG GGGCCATGAG CAGCACGCCG GCGTGCAGCG CCCCGTCGAA GATGCGCATG 28980

TTGGCCGTCG ACGCGGTGTT GGCGCCCGCG TCGGGCGCCG CGGAGCACAG CAGCGCCGTC 29040

GTGCGCTCGG CCATGTTGTG CGCCAGCACC TGCAGCGTGA GCATGGCGGG CCCGTCGACG 29100 ACGACGCGCC CGTTGTGGAA CATGGCGTTG ACCGTGTTGG CCACCAGATT GGCGGGATGC 29160

AGCGGGTGGG CGGGGTCGGT CACGGGATCG CTCGGGCACT CCTCGCCGGG GGCGATCTCC 29220

GGGACCACCA TGTTCTGCAG CGTGGCGTAC ACGCGGTCGA AGCGGACCCC CGCGGTGCAG 29280

CAGCGCCCCC GCGAGAAGGC CGGCACCAGC ACGTAATAGT AGATTTTGTG GTGGACGGTC 29340

CAGTCGGCCG GCCGGTGCGG CCGGTCGTCG GCGGCGTCGG CCGCGCGGGC CTGGGTGTTG 29400 TGCAGCAGCC GGCCGTCGTT GCGGTTAAAG TCGGCCGTCG CCACGTTGCA CGCCGCCGCG 29460

TAGACGGGCT CGTGTCCCCC CGCGTCAATC CGGCAGTCTC GGTGGCGGTC CAGGGCCGCG 29520

TGTCGCATAA GGCCGTCGCA GTCCCACACG AGGGGCGGCA GCAGCGCCGG GTCGCGCATC 29580

AGGTGATTCA GCTCGGCCTG AGCCTGCCCG CCCAGCTCCG GGCCCGGCAG GGTAAAGTCG 29640 TCCACCAGCT GGGCCAGGGC CTCGACGTGG GCCACCAGGT CCCGATACAC GGCCATGCAC 29700

TCCTCGGGGA GGTCGCCCCC GAGGTAGGTC ACGATGTACG AGACCAGCGA GTAGTCGTTC 29760

ACGAACGCCG CGCATCGCGT GTTGTTCCAG TAGCTGGTGA TGCACTGAGT CACGAGCCGC 29820

GCCAGGGCGC AGAACACGTG CTCGCTGCCG TGAATCGCGG CTTGCAGCAG GTAAAACACC 29880 GCCGGGTAGC TGCGGTCCTC GAACGCCCCG CGGACGGCGG CTATGGTAGC CGGCGCCATG 29940

GCGTGGCGGC CAACGCCGAG CTCCAGGCCC CGGGCGTCAC GAAACGCCAC CGGACACAGC 30000

GCCAGGGGCA GGTTGCCGTT GACCACGCGC CAGGTGGCCT GGATCGCCCC CGGACCGGCC 30060

GGGGGGACTT CGCCGCCGGG AAGCTCGACG TCGGCCACGC CCGCGAAGAA GTCGAACGCG 30120

GGGTGCAGCT CCAGAGCCAG GTTGGCGTTG TCGGGCTGCA TGAACTGCTC CGCGGTCATC 30180 TGGCACTCGG CGACCCACCG GACCCGGCCG TGGGCGAGGC GCTGCCGCCA GGCGTTCAGA 30240

AAACGCTGCT GCATGTCCGC GCCGGGGCCG GCCGGGGCCG CGACGTACGC CCCGTACGGA 30300

TTCGCGGCCT CGACGGGGTC GTGGTTCACG CCCCCGACGG CCGCGTCGAT GTTCATGAGC 30360

GAAGGATGAC ACACGGTCCC GACCGCGTTC TCCATGGACA GCCGCAGAAC CTGGTGGTCC 30420

TTTCCCCAAA AAAACAGCTG CCGGGGAGGG AACGCGCGGG GCTCCGGGTG GCCGGGGGCG 30480 GGCACCAGGT CCCCGGCGTG CGCGGCGAAG CGCTCCATGG CCGGGTTGAA CAGCCCCAGG 30540

GGCAGGACGA ACGTCAGGTC CATGGCGCCC ACCAGGGGGT AGGGCACGTT GGTGGCGGCG 30600

TAGATGCGCT TCTCCAGGGC CTCCAGGAAG ACCAGCCTGT CGCCTATGGC CACCAGATCC 30660

GCGCGCACGC GCGTTGTCTG GGGGGCGCTT TCGAGTTCAT CCAGCGTCTC CCGGTTCGCC 30720

TCGAGTTGCT CCTCCTGCAT CTCCAGCAGG TGGCGGCCCA CGTCGTCCAG GCTCCGCACG 30780 GCCTTGCCCA TCACCAGCGC CGTGACGAGG TTGGCCCCGT TCAAGACCAT CTCGCCGTAG 30840

GTCACCGGCA CGTCGGCCTC GGTGTCCTCC ACCTTCAGGA AGGACTGCAG GAGGCGCTGT 30900

TTGATGGCGG CGGTGGTGAC CAGCACCCCG TCGACCGGCC GCCCGCGCGT GTCGGCGTGC 30960

GTCAGGCGGG GCACGGCCAC GGACGGCTGC GTCGCCGTGG TCAGGTCCAC GAGCCAGGCC 31020

TCGATGGCCT CGCGGCGATG GCCCGCCTTG CCCAGGAAGA AGCTCGTGTC GCAAAAGCTC 31080 CGCTTCAGCT CGGCGACCAG GGTCGCCCGG GCGACCCTGG TCGCCAGGCG CCCGTTGTCG 31140

AGATATCGTT GCATGGGCAA CAGCAGGGCC AGGGGAGGCG CCTTCTCCAA CAGCACGTGC 31200

AGCATCTGGT CGGCCGTGCC GCGCTCAAAC GCCCCCAGGA CGGCCTGGAC GTTGCGCGCG 31260

AGCTGCTGGA TGGCGCGCAG CTGGCGATGC AGGCTAATGC CCGTCCCGTC CAGGGCCTCC 31320

CCCGTGAGCA GGGCAATGGC CTCGGTGGCC AGGCTGAAGG CGGCGTTCAG GGCCCGGCGG 31380 TCGATGACCT TCGTCATGTA ATTATGCACG GGCTGCTCGA CGGGGTGCGG GCCGTCGCGG 31440

GCGATGAGGG GCTGGTGGAC CTCGAACTGC ACACGCCCTT CGTTCATGTA AGCCAGCTCC 31500

GGGAACTTGG TGCACACGCA CGCCACGGAC AGGCCGAGCT CCAGAAAGCG CACGAGCGAC 31560

AGGGTGTTGC AGTAGGACCC CAGCAGGGCG TCAAACTCTA CGTCATACAG GCTGTTTTCG 31620

TCGGAGCGCA CGCGGGCGAA AAAATCAAAG AGTCTGCGGT GGGACGCCAC CTCGATCGTA 31680 CTCAGGATGG AGCCGGTGGG CACCATGGCC GCGGCGTACC GGTAACCCGG GGGGTCGCGG 31740

GCAGGAGCGG CCATTGGGTT CCTTGGGGGA TTCGCAGGCT CCATCAAGCC AAGCTCGGGA 31800

AGGCCAAGCC CCTCCCACAC AACGCCTCAC CGCCGGCGGA CGCGACTAAC AACCCACGGG 31860

CCGCCAAAAA CCCCAAGGGG CAACCCGACC AACAACAGGC GAGGGGAGGA AAGGCGTAAA 31920

GGGGGCGTTG GGAGGCAAAA AGAAAGAAAA CACCCAGACG TAGGCCCGAG GACCGGCCGG 31980 CGTCCTCTGT CCCCGAGCAC CCACTGTGCC CAACAGGCAC GGGGGCGAGC TGCCCCTGCC 32040

TTATATACCC CCCCGCCACA CCCCCGTTAG AACGCGACGG GTGCCTTCAA GATGGCCCTG 32100

GTCCAAAAGC GTGCTAGAAA AAAGTTGGTA AAGGCGGCAA AGCAGTCCGC CGCCGCCACC 32160

CACATGGCGG CGCCGGCCGC GCAGGCGATT CCCAGAGAAC GGGCGCGGAG GGGATCCGTG 32220 CGGGGCAGCA GCTGGCTGGC GGTGATCCAA TGGAAAAGCC CGTCGGGACT GAACGTCTCA 32280

TGGGCGGCCG CCACCAGGGC GCACAGGGCC GCGCCGCCCA TGATCACGCA CAACCCCCAA 32340

AACACGGGTG GCGACAACGG CAGGCGATCC CGTTTGATGT TCACGTACAG GAGGAGCGCC 32400

CGTGCCAGCC ACGTGACATA GTAGGCGAGG ACGGCGGCTA TAATACATGC CGGCGCCACC 32460 GCCCGTCCGG TCCACCCGTA ATACATGCCC GCGGCCACCA GCTCCAGCGG CTTGAGGACC 32520

AGGAACGACC AAGCAAACAT CACCACCCGC TTGGAAAAGA CCGGCTGGGT GTGGGGCGGA 32580

AGACGCGAGT AGGCCGAACT GACAAAAAAA TCAGACGTGC CGTACGAGGA CAGCGAAAAC 32640

TGTTCATCGA GCGGCAGTTC GCCGTCCTCC CCGCCACACG CGGCCTCGTA TACCAGCTCG 32700

CGATCCAACA AAGGAACATC ATCCCGCATT GTCATGGTCG GTGCGGGGAG CCGGCGAGGC 32760 AGCGAAACCG AAAGTAGTGC TGGCGGCGCG GGCCCGGGTC CGGACCCAAG CTTCAGGGAT 32820

GGGGGGCGGA GGCCAAAATC AAACAAGCAC CGCGCGGGTT CTACACACAA CCCCCACCCG 32880

GGTAGTATCC GCGGATGCGA GTGCCTGGCG AAGTCACGTC CCAGCAGGAT ATAAACCTCG 32940

GCCGTTGGGC CCGGAACCCC CGAAATTCAC ACCCACGCCC TGACGCCCAA ATCATGGGTG 33000

GATGTGGTTC GCGAGCCGCA CATCCGTGCG TCCGCCCTCC CCCGCGGGCT GATGACGTGG 33060 CGGTTAGTCA GTGGGAAGGC AGGGGGAAAG ATGGGTTGGG GGAGGAAACG AAGAAAACAC 33120

CCAGAGGGCC ACGTCGGGAA TGCGCCCGGA GTTGTCCTTA AAAGGCCGGC CGTGCGTGAC 33180

GGAAGCCGTC GTTTGCCCAA GCACCGACGC CGCGATCCAC AGTGGGGGGA GTTCCTCCGT 33240

CCGGCCACAA CCCTACGCGC GGGCGGCACG CGCGAGAGCA ACCCACGGGT CCCGTTCGCG 33300

CCACCGCCAG CCCTTGCTCC CACCACCCTC CTCCCACCAC CCCACTATTC CCCCCCCCCC 33360 AAGTCCGCCC CGTGGCTCGC CGGCCATGGA GCTCAGCTAT GCCACCACCC TGCACCACCG 33420

GGACGTTGTG TTTTACGTCA CGGCAGACAG AAACCGCGCC TACTTTGTGT GCGGGGGGTC 33480

CGTTTATTCC GTAGGGCGGC CTCGGGATTC TCAGCCGGGG GAAATTGCCA AGTTTGGCCT 33540

GGTGGTCCGG GGGACAGGCC CCAAAGACCG CATGGTCGCC AACTACGTAC GAAGCGAGCT 33600

CCGCCAGCGC GGCCTGCGGG ACGTGCGGCC CGTGGGGGAG GACGAGGTGT TCCTGGACAG 33660 CGTGTGTCTG CTAAACCCGA ACGTGAGCTC CGAGCGAGAC GTGATTAATA CCAACGACGT 33720

TGAAGTGCTG GACGAATGCC TGGCCGAATA CTGCACCTCG CTGCGAACCA GCCCGGGGGT 33780

GCTGGTGACC GGGGTGCGCG TGCGCGCGCG AGACAGGGTC ATCGAGCTAT TTGAGCACCC 33840

GGCGATCGTC AACATTTCCT CGCGCTTCGC GTACACCCCC TCCCCCTACG TATTCGCCCT 33900

GGCCCAGGCG CACCTCCCCC GGCTCCCGAG CTCGCTGGAG CCCCTGGTGA GCGGCCTGTT 33960 TGACGGCATT CCCGCCCCGC GCCAGCCCCT GGACGCCCGC GACCGGCGCA CGGATGTCGT 34020

GATCACGGGC ACCCGCGCCC CCAGACCGAT GGCCGGGACC GGGGCCGGGG GCGCGGGGGC 34080

CAAGCGGGCC ACCGTCAGCG AGTTCGTGCA AGTGAAGCAC ATCGACCGTG TTGTGTCCCC 34140

GAGCGTCTCT TCCGCCCCCC CGCCGAGCGC CCCCGACGCG AGTCTGCCGC CCCCGGGGCT 34200

CCAGGAGGCC GCCCCGCCGG GCCCCCCGCT CAGGGAGCTG TGGTGGGTGT TCTACGCCGG 34260 CGACCGGGCG CTGGAGGAGC CCCACGCCGA GTCGGGATTG ACGCGCGAGG AGGTCCGCGC 34320

CGTGCATGGG TTCCGGGAGC AGGCGTGGAA GCTGTTTGGG TCGGTGGGGG CTCCGCGGGC 34380

GTTTCTCGGG GCCGCGCTGG CCCTGAGCCC GACCCAAAAG CTCGCCGTCT ACTACTATCT 34440

CATCCACCGG GAGCGGCGCA TGTCCCCCTT CCCCGCGCTC GTGCGGCTCG TCGGTCGGTA 34500

CATCCAGCGC CACGGCCTGT ACGTTCCCGC GCCCGACGAA CCGACGTTGG CCGATGCCAT 34560 GAACGGGCTG TTCCGCGACG CGCTGGCGGC CGGGACCGTG GCCGAGCAGC TCCTCATGTT 34620

CGACCTCCTC CCGCCCAAGG ACGTGCCGGT GGGGAGCGAC GCGCGGGCCG ACAGCGCCGC 34680

CCTGCTGCGC TTTGTGGACT CGCAACGCCT GACCCCGGGG GGGTCCGTCT CGCCCGAGCA 34740

CGTCATGTAC CTCGGCGCGT TCCTGGGCGT GTTGTACGCC GGCCACGGAC GCCTGGCCGC 34800 GGCCACGCAT ACCGCGCGCC TGACGGGCGT GACGTCCCTG GTCCTGACCG TGGGGGACGT 34860

CGACCGGATG TCCGCGTTTG ACCGCGGGCC GGCGGGGGCG GCTGGCCGCA CGCGAACCGC 34920

CGGGTACCTG GACGCGCTGC TTACCGTTTG CCTGGCTCGC GCCCAGCACG GCCAGTCTGT 34980

GTGAGATATC CCAATAAAGT GCAGTCGTTT TCTAACCCAC GGATGCCGTT GTATGCCTAT 35040 ACGGGGGACT ATGGGGGGGG GGGGAAAGGA AAGGAAACAG GAATGGAGAA GGGAAAGGAA 35100

CAGAGGCGGT AGCGGACGCA CGGCGGACAC AATAACAAAC AGACCGCGGA CACGGAGGGA 35160

GTCGGTTGGG TTGGGCGTGG ACGCCGCTGC GTCCACACAC CCGTTTATTC GCGTCTCCAC 35220

AAAAATGGGA CGCACGTTCG GACCACCCTG AGGATGCCCG CCAGGGCCGC GGTGATCATA 35280

ACGACCCCCA GCGCGGACGC GGCCAGAAAC CCGGGGGCGA TGGTGGCGAT GGGCAGCGTG 35340 TCAAAGGCCA GCAGATGAAT CACAGTTCCG TTGGGGAACA ACAACAGGGC CACGGACGGC 35400

ACGTCGCTGG AAAACACGTT CGGGGTGCCC GCCACCGGCC CCTGGGCCAG CTGCTGTTGG 35460

GTGGCATCCG TGTCCACCAG CAGCACCGAC ATGACCTCCC CGGCCGGGGT GTAGCGCAGA 35520

AACACGGCCC CCACGAGGCC GAGGTCGCGC CGGTTTTCGG TGCGCACCAG CCGCTTCGGC 35580

TCAATCTCCC GCGCGTGCCC TTCGCAGGTG GCGGTGAGAT AGGTGATAAA CAGCGGGCGG 35640 CGGACGTCAA CGCCCGTAAG CTTGTATCCG ATCCCGCGGG GCAAGGGGGT GTGGGTGACG 35700

ACGTAGCTGG CGTTGTGGGT GATGGGCACG AGGATCCGGG GCTCCGCGTT GTGCGACGGG 35760

CCGCTACACT GGTGGGTGGC CTCCGGGACG AAGGCGCGGA TCAGGGCGTT GTAGTGCGCC 35820

CAGCGCGTGA GAACGGAGGC CACGCCGCGG GTCTGTTGTG CCATGACGTC CGCCGGGATG 35880

TCGGATCGGG TGGCCATGGC CAGCGCGTCC AGGATGAACC CGCCCTCGGC GAGATCGAAG 35940 CGCAGGGAAG CTGCGCATGG GGAAAAGTGG TCCGGGAGCC AGAAGAGGTT TTTCTGGTGG 36000

TCGGTCCTGG CTAGCGCGGC CCGGAGATCG GCGTGGGTCG CCGCGGCGAC GTCGGACGTA 36060

CACAGGGCCG TGGTTATGAG GAGGCCCCGG CGGGCGCGTT CCCGCTGCTC GGCCGAGGGC 36120

GCGCCCGCCA GGAACGGCGC CCGGAGGACG GCCGTGGCGT AAAACAGCGC TCGGCGGACC 36180

ATCGGGGCGG TTAGCGCGCG GCCGCCGAGA AACTCGGCGT ACAGGGCGTC GATCAGGCGG 36240 GCCGCGCTCG GGGCCACCGC GCCATAGGCC GCGGGGCTGT CCAACACGAA CGCCAGCTGA 36300

TAGCCCAGCG CGTGCGCCGC CAGGCTCTGC TCTCGCTCGA GGATCGCGGC CACCAGATGC 36360

CCGAGGCGCG CCTCCAGCCG CAGGCGGGCC GCCGGGTCCA ACACGGACAC GTTCAGGAAC 36420

ACCGAGTCGG CCGCGCAGCC CGCTGCTCCC CGGGCGGCCA GGCCGGCCAG CACGCGCGAG 36480

TGGGCCAAAA AGCCCAGCAG GTCGGAGAGG CGAATCGCGT CGTGGGCGTG GGCCGCGTTG 36540 ACGAACGCAA ACCCCGACGA GGCGAGCAGC CCCGCGAGGC GCCAGAACAG GGACGGACGC 36600

GCGTCCGTGC CGGAGCCCGG GTCCTCCCCC AAAAACTCCG CATAGGCCCG CGACATATAC 36660

TGGGCGTAGT TCGTGCTCTC CTCGGGGTAG CCGGCCACCC GCCGGAGGGC GTCCAGCGCC 36720

GAGCCGTTGT CGGCGGGCGT CGGGGCCCCC AGGACAAAGA CGCGATACCT GGGGCCGGCC 36780

GGAGGCCCGG GGAGCACCGC GGGGGCGTTT TCGTCGGTCG GATTTCCGAC CCGAGCGAGG 36840 GTCTTGTCCG CAGGCACCAC TATGATCTCG GCCGGAGGGC TGTCCCGCAT CGATATCACG 36900

AGCCCCATGA AGCCCTTCCC GTATCGCGCG CGCACGAGCG CGGCGTCGCA CCCGAACGCC 36960

AGCCCGCCCG TCGTCCAGAC GCCCACGGGC CACGTCGAGG CCGACGGGGA GAGGTACACG 37020

TACCGACCCG GAGTCCGTAG CAGGCCCCTG GCGGCCAGCC AGGTCACGGA TGCGTTGTGC 37080

AGATGCGCGA TGCTCAGGTT CGTCGTCGGA TGCCTCGGTG TCCCCGCGGG CGGCCCCGGG 37140 GGCGGCGCGT TGCGTCGGCC GTCCGGGTGC CTCTCGGTCG CCCCGTCGTC TCCCCGCGGG 37200

AACGTAAGCC CCTCGCGGTC CGGCGCGGCC GCGAATGTTA CCCAGGCCCG GGACCGCAAC 37260

AGCGCGGAGG CGCCGGGGTT GTGCGACAGT CCCTTGAGCT GGGTCACCTC GGCGGGGGGA 37320

CGGGACGTGG GCCCCGCCTC GGGGAGCTCG GGCAGGCTCG CGTTCCGAGG CCGGCCGAGC 37380 AGATAGGTCT TTGGGATGTA AAGCAGCTGC CCGGGGTCCC GAGGAAACTC GGCCGTGGTG 37440

ACCAACACGA AACAAAAGCG CTCGGCGTAC CACCGAAGCA TGGGCACGGA TGCCGTAGTC 37500

AGGTTGAGTT CGCCCGGGGG CGCCAAGCGT CCGCGCTGGG GGTCGCTGGC GTCGGGGGTG 37560

TTGGGCAACC ACAGACGCCC GGTGTTTGTG TCGCGCCAGT ACGTGCGGGC CAACCCCAGA 37620 CCGTGCAAAA ACCACGGGTC GATTTGCTCC GTCCAGTACG TGTCATGGCC CCCGGCAACG 37680

CCCACCAGGA CCCCCATCAC CACCCACAGA CCGGGGCCCA TGGTCGTCCG TCCCGGCTGC 37740

CAGTCCGCAG ATGGGGGGGT GTCCGTACCC ACGGCCCAAA GAGGCTCCGC ACCTCGGAGG 37800

CTATCGGAGG CCCTTTGTTG CCGTAAGCGC GGGCCAAAGG ATGGGGTGGG GTGAGGGTAA 37860

AAGCACAAAG GGAGTACCAG ACCGAAAACA AGGACGGATC GGCCCGCTCC GTTTTTCGGT 37920 GGGGTGCTGA TACGGTGCCA GCCCTGGCCC CGAACCCCCG CGCTTATGGA CACACCACAC 37980

GACAACAATG CCTTTTATTC TGTTCTTTTA TTGCCGTCAT CGCCGGGAGG CCTTCCGTTC 38040

GGGCTTCCGT GTTTGAACTA AACTCCCCCC ACCTCGCGGG CAAACGTGCG CGCCAGGTCG 38100

CGTATCTCGG CGATGGACCC GGCGGTTGTG ACGCGGGTTG GGATCATCCC GGCGGTGAGG 38160

CGCAACAGGG CGTCTCGACA CCCGACGGGC GACTGATCGT AATCCAGGAC AAATAGATGC 38220 ATCGGAAGGA GGCGGTCGGC CAAGACGTCC AAGACCCAGG CAAAAATGTG GTACAAGTCC 38280

CCGTTGGGGG CCAGCAGCTC GGGAACGCGG AACAGGGCAA ACAGCGTGTC CTCGATGCGG 38340

GGCAGAGACC CCGCGCCGTC CTCGGGGTCG GGGCGCGGGG TCGCCGCGGC GACCCCCGTC 38400

AGCCGGCCCC AGTCCTCCCG CCACCTCCCG CCGCGCTGCA GGTACCGCAC CGTGTTGGCG 38460

AGTAGATCGT AGACACGGCG AATGGCGGAC AGCATGGCCA GGTCAAGCCG CTCGCCCGGG 38520 CGTTGGCGTC TGGCCAGGCG GTCGGCGTGT TCGGCCTCCG GAAGGACACC CAGGACCAGG 38580

TTCGTGCCGG GCGCGGTCGG GGGCATGAGG GCCACGAACG CCAACACGGC CTGGGGGGTC 38640

ATGCTTCCCA TGAGGTACCG CGCGGCCGGG TAGCACAGCA GGGAGGCGAT AGGGTGCCGG 38700

TCGAAAACAA GGGTGAGGGC CGGGGGCGGG GCTTGCGGGC CCACAGCCTC CCCCCCGATA 38760

TGAGGAGCCA AAACGGCGTC CGTCGCCGCA TAAGGCGTGC TCATTGTTAT CTGGGCGCTG 38820 GTCATTACCA CCGCCGCCTC CCCGGCCGAT ATCTCGCCGC GGTCCAGACG GTGCTGCGTG 38880

TTGTAGATGT TCGTCAGGGT CTCGGAGGCC CCCAGCACCT GCCAGTAAGT CATCGGCTCG 38940

GGGACGTAGA CGATATTGTC GCGCGGCCCC AGGGCCTCCA TCAGCTGCGC GGAGGTGGTG 39000

GTCTTCCCCA CCCCGTGGGG TCCGTCTATA TAAACCCGCA GCAGCGTGGG CAGCTCCGGA 39060

TCCCCGCGGG CTTCGGAGGC CCCCTGGCGA TGGCTAGGAC GGGACGCCGC GCGGCCGTCG 39120 GTAGGCCCGC TCGCACGAGC AGCCTGACCG AACGCAGGCG CGTGCTGTTG GCCGGCGTGA 39180

GAAGCCATAC CCGCTTCTAC AAGGCGTTCG CCCGAGAGGT GCGGGAGTTC AACGCCACCA 39240

GGATTTGTGG AACGCTGCTG ACGCTGATGA GCGGGTCGCT GCAGGGTCGC TCGCTGTTCG 39300

AGGCCACGCG CGTCACCTTA A ATGCGAAG TGGACCTCGG GCCGCGCCGC CCAGACTGCA 39360

TCTGCGTGTT CGAATTCGCC AATGACAAAA CGTTGGGAGG TGTGTGCGTC ATCCTGGAGC 39420 TAAAGACATG CAAATCGATT TCTTCCGGGG ACACGGCCAG CAAACGCGAA CAGCGGACCA 39480

CGGGCATGAA GCAGCTGCGC CACTCCCTGA AGCTGCTGCA GTCGCTCGCG CCTCCGGGGG 39540

ACAAGGTCGT CTACCTGTGT CCTATTTTGG TGTTTGTCGC GCAGCGTACG CTGCGCGTCA 39600

GCCGCGTGAC CCGGCTCGTC CCGCAAAAGA TCTCCGGCAA CATCACCGCG GCCGTGCGGA 39660

TGCTCCAAAG CCTGTCCACG TATGCCGTGC CGCCGGAACC GCAGACCCGG CGGTCGCGGC 39720 GCCGGGTCGC CGCGACCGCC AGACCGCAAA GGCCCCCCTC CCCGACACGT GACCCGGAAG 39780

GCACGGCGGG TCATCCGGCC CCACCAGAGA GCGACCCCCC CTCCCCAGGG GTCGTAGGCG 39840

TCGCTGCGGA GGGTGGGGGT GTGCTTCAGA AAATCGCGGC GCTTTTTTGC GTGCCGGTGG 39900

CCGCCAAGAG CAGACCCCGG ACCAAAACCG AGTGAGGTTC TGTGTGTTGT TTTTTTTCCT 39960 CGTTTTGTTT TCTCTTCTTT CCCCCCCCCC TCCCCCGCTT CTGGCCAAGC ATCCTCACCT 40020

GCTTAAGCGG AACCCGCGGG CGCGCGGGGA CTCATTTGTC GCCGGCGACA CCCACCCGAC 40080

AACAGCCCCT GGGTGTAGAC CGCTGTCGCC CCCGTCTGTC GCCTCTCCCT TTTTTCCCCC 40140

CCTCAAAGAA CGTGGTGTTG GGCGCCGGCC AATTCTTCCC GGAGCGCCGT CGTCGCCCGC 40200 CCGCCGCCCT CGAACATGGA CCCGTACTAC CCTTTCGACG CGCTGGACGT TTGGGAACAC 40260

AGGCGCTTCA TCGTCGCCGA CTCCAGGAGC TTCATCACCC CCGAGTTCCC CCGGGACTTC 40320

TGGATGTTGC CCGTGTTCAA CATCCCCCGG GAGACGGCGG CGGAGCGGGC GGCAGTGCTG 40380

CAGGCCCAGC GCACCGCGGC CGCGGCGGCC CTGGAGAACG CCGCCCTCCA GGCCGCCGAG 40440

CTGCCCGTCG ACATCGAGCG CCGGATACGC CCGATCGAGC AGCAGGTGCA TCACATCGCC 40500 GACGCCCTGG AGGCGCTGGA GACCGCGGCG GCCGCGGCCG AAGAGGCGGA TGCCGCGCGG 40560

GACGCCGAGG CGAGGGGGGA GGGCGCTGCG GACGGGGCAG CGCCGTCGCC CACCGCGGGC 40620

CCCGCCGCCG CGGAGATGGA GGTTCAGATC GTACGCAACG ACCCGCCGCT ACGATACGAT 40680

ACCAACCTCC CCGTGGATCT GCTACACATG GTGTACGCGG GCCGCGGGGC CGCGGGTTCG 40740

TCGGGAGTCG TCTTTGGTAC CTGGTACCGC ACGATCCAGG AACGCACCAT CGCGGACTTC 40800 CCCCTGACCA CCCGCAGCGC CGACTTTCGA GACGGGCGCA TGTCCAAGAC CTTCATGACC 40860

GCGCTGGTCC TGTCTCTGCA GTCGTGCGGC CGGCTGTACG TGGGCCAGCG CCACTATTCC 40920

GCCTTCGAGT GCGCCGTGCT GTGTCTGTAT CTGCTGTACC GAACCACCCA CGAGTCCTCC 40980

CCCGATCGCG ATCGCGCTCC CGTTGCGTTC GGGGACCTGC TGGCCCGCCT GCCGCGCTAC 41040

CTGGCGCGTC TGGCCGCGGT AATCGGCGAC GAGAGCGGAC GCCCGCAGTA CCGCTACCGC 41100 GACGACAAGC TGCCCAAAGC GCAGTTCGCG GCGGCCGGCG GCCGCTACGA GCACGGGGCC 41160

CTGGCCACCC ACGTCGTGAT CGCCACGTTG GTGCGCCACG GGGTGCTACC GGCGGCCCCG 41220

GGCGACGTTC CCCGAGACAC CAGCACCCGC GTGAACCCCG ACGACGTGGC CCACCGCGAC 41280

GACGTCAACC GCGCCGCCGC CGCGTTTTTG GCACGCGGCC ACAACCTCTT CCTGTGGGAG 41340

GACCAGACGC TGCTGCGGGC GACCGCCAAC ACCATTACGG CCCTGGCCGT GCTTCGGCGG 41400 CTCCTCGCGA ACGGCAACGT GTACGCGGAC CGCCTCGACA ACCGCCTGCA GCTGGGCATG 41460

CTGATCCCGG GAGCCGTCCC GGCGGAGGCC ATCGCTCGGG GGGCGTCCGG ATTGGACTCG 41520

GGCGCCATAA AAAGCGGCGA CAACAACCTG GAGGCGCTGT GCGTTAACTA TGTACTTCCG 41580

CTGTATCAGG CAGACCCCAC GGTCGAGCTG ACCCAGTTGT TTCCGGGGCT GGCCGCCCTG 41640

TGCCTGGACG CCCAGGCGGG GCGGCCACTG GCGTCGACGA GGCGCGTGGT GGATATGTCG 41700 TCGGGCGCCC GCCAGGCGGC GCTCGTGCGC CTCACCGCGC TGGAGCTCAT CAACCGCACC 41760

CGCACAAACA CCACCCCTGT GGGGGAGATT ATTAACGCCC ACGATGCCTT GGGGATACAA 41820

TACGAACAGG GCCTGGGGCT GCTCGCCCAG CAGGCACGCA TCGGCTTGGC GTCGAACGCC 41880

AAGCGATTCG CCACGTTCAA CGTGGGCAGC GACTACGACC TGTTGTACTT TTTGTGTCTC 41940

GGGTTCATTC CCCAGTACCT GTCCGTGGCC TAGGGAAGGG TGGGGGTGGT GGTGGTGGGG 42000 TGTTTTTCTG CTGTTGTTGT TTCTGGTCCG CCTGGTCACA AAAGGCACGG CGCCCCGAAA 42060

CGCGGGCTTT AGTCCCGGCC CGGACGTCGG CGGACACACA ACAACGGCGG GCCCCGTGGG 42120

TGGGTAAGTT GGTTCGGGGG CATCGCTGTA TTCCCTTGCC CGCTTCCACC CCCCCTTCCC 42180

GTTTTGTTTG TTTGTGCGGG TGCCCATGGC GTCGGCGGAA ATGCGCGAGC GGTTGGAGGC 42240

GCCTCTGCCC GACCGGGCGG TGCCCATCTA CGTGGCCGGG TTTTTGGCCC TGTACGACAG 42300 CGGGGACCCG GGCGAGCTGG CCCTGGACCC AGACACGGTG CGTGCGGCCC TGCCTCCGGA 42360

GAACCCCCTG CCGATCAACG TAGACCACCG CGCTCGGTGC GAGGTGGGCC GGGTGCTCGC 42420

CGTGGTCAAC GACCCTCGGG GGCCGTTTTT TGTGGGGCTG ATCGCGTGCG TGCAGCTGGA 42480

GCGCGTCCTC GAGACGGCCG CCAGCGCCGC TATTTTTGAG CGCCGCGGAC CCGCGCTCTC 42540 CCGGGAGGAG CGTCTGCTGT ACCTGATCAC CAACTACCTG CCATCGGTCT CGCTGTCCAC 42600

AAAACGCCGG GGGGACGAGG TTCCGCCCGA CCGCACCCTG TTTGCGCACG TGGCCCTGTG 42660

CGCCATCGGG CGGCGCCTTG GAACCA-TCGT CACCTACGAC ACCAGCCTAG ACGCGGCCAT 42720

CGCTCCGTTT CGCCACCTGG ACCCGGCGAC GCGCGAGGGG GTGCGACGCG AGGCCGCCGA 42780 GGCCGAGCTC GCGCTGGCCG GGCGCACCTG GGCCCCCGGC GTGGAGGCGC TCACACACAC 42840

GCTGCTCTCC ACCGCCGTCA ACAACATGAT GCTGCGTGAC CGCTGGAGCC TCGTGGCCGA 42900

GCGGCGGCGG CAGGCCGGGA TCGCCGGACA CACGTACCTT CAGGCGAGCG AAAAATTTAA 42960

AATATGGGGG GCGGAGTCTG CCCCTGCGCC GGAGCGCGGG TATAAAACCG GCGCCCCGGG 43020

TGCCATGGAC ACATCCCCCG CCGCGAGCGT TCCCGCGCCG CAGGTCGCCG TCCGTGCGCG 43080 TCAAGTCGCG TCGTCGTCGT CTTCTTCTTC TTCTTTTCCG GCACCGGCCG ATATGAACCC 43140

CGTTTCGGCA TCGGGCGCCC CGGCCCCTCC GCCGCCCGGC GACGGGAGTT ATTTGTGGAT 43200

CCCCGCCTTT CATTACAATC AGCTCGTCAC CGGGCAATCC GCGCCCCACC ACCCGCCGCT 43260

GACCGCGTGC GGCCTGCCGG CCGCGGGGAC GGTGGCCTAC GGACACCCCG GCGCCGGCCC 43320

GTCCCCGCAC TACCCGCCTC CTCCCGCCCA CCCGTACCCG GGTATGCTGT TCGCGGGCCC 43380 CAGTCCCCTG GAGGCCCAGA TCGCCGCGCT GGTGGGGGCC ATCGCCGCCG ACCGCCAGGC 43440

GGGTGGGCTT CCGGCGGCCG CCGGAGACCA CGGGATCCGG GGGTCGGCGA AGCGCCGCCG 43500

ACACGAGGTG GAGCAGCCGG AGTACGACTG CGGCCGTGAC GAGCCGGACC GGGACTTCCC 43560

GTATTACCCG GGCGAGGCCC GCCCCGAGCC GCGCCCGGTC GACTCCCGGC GCGCCGCGCG 43620

CCAGGCTTCC GGGCCCCACG AAACCATCAC GGCGCTGGTG GGGGCGGTGA CGTCCCTGCA 43680 GCAGGAACTG GCGCACATGC GCGCGCGTAC CCACGCCCCC TACGGGCCGT ATCCGCCGGT 43740

GGGGCCCTAC CACCACCCCC ACGCAGACAC GGAGACCCCC GCCCAACCAC CCCGCTACCC 43800

CGCCGAGGCC GTCTATCTGC CGCCGCCGCA CATCGCCCCC CCGGGGCCTC CTCTATCCGG 43860

GGCGGTCCCC CCACCCTCGT ATCCCCCAGT TGCGGTTACC CCCGGTCCCG CCCCCCCGCT 43920

ACATCAGCCC TCCCCCGCAC ACGCCCACCC CCCTCCGCCG CCGCCGGGAC CCACGCCTCC 43980 CCCCGCCGCG AGCTTACCCC AACCCGAGGC GCCCGGCGCG GAGGCCGGCG CCTTAGTTAA 44040

CGCCAGCAGC GCGGCCCACG TGAACGTGGA CACGGCCCGG GCCGCCGATC TGTTTGTGTC 44100

ACAGATGATG GGGTCCCGCT AACTCGCCTC CAGGATCCGG ACTTGGGGGG GGTGTGTGTT 44160

TTCATATATT TTAAATAAAC AAACAACCGG ACAAAAG AT ACCCACTTCG TGTGCTTGTG 44220

TTTTTGTTTG AGAGGGGGGG GGTGGAGTGG GGGGGAAAGT GGGCCGAATG ACACAAAAAT 44280 TAGGTCGGAG GGGTGAGGGG GGGGGGGCTA GGAGCCGAAC CGATGGCCCC CACACGCGAC 44340

GGAAGGCCCG GAAGACTACC ACGGGGAGGG GGTGTGGAAA GCGACCGGTC GCAGGGAGAC 44400

GGGGTTGGTT TGGGGTTGGT TTGGGGTTGG TTTTCCCGTT AGCACATGTC TGCATTTGTT 44460

TTTCTAGTCA CACGCCCCCC CCCCCAAATA AAAACCAAGG CAAAACAATA CCAGAAGTCA 44520

TGTGTATTTT TGAACATCGG TGTCTTTTTA TTTATACACA AGCCCAGCTC CCCTCCCCTC 44580 CCTTAGAGCT CGTCTTCGTC TCCGGCCTCG TCCTCGTTGT GGAGCGGAGA GTACCTGGCT 44640

TTGTTGCGCT TGCGCAGAAC CATGTTGGTG ACCTTGGAGC TGAGCAGGGC GCTCGTGCCC 44700

TTCTTTCTGG CCTTGTGTTC CGTGCGCTCC ATGGCCGACA CCAAAGCCAT A ATCGGATC 44760

ATTTCTCGGG CCTCGGCCAA CTTGGCCTCG TCAAACCCGC CCCCCTCCGC GCCTTCCTCC 44820

CCCTCCCCGC CCACGCCCCC GGGGTCGGAA GTCTTGAGTT CCTTGGTGGT GAGCGGATAC 44880 AGGGCCTTCA TGGGATTGCG TTGCAGTTGC AGGACGTAGC GGAAGGCGAA GAAGGCCGCG 44940

ACCAGGCCGG CCAGGACCAG CAGCCCCACG GCAAGCGCCC CGAAGGGGTT GGACATAAAG 45000

GAGGACACGC CCGAGACGGC CGACACCACG CCCCCCACTA CTCCCATGAC TACCTTGCCG 45060

ACCGCGCGCC CCAAGTCCCC CATCCCCTCG AAGAACGCGC ACAGCCCCGC GAACATGGCG 45120 GCGTTGGCGT CGGCGCGGAT GACCGTGTCG ATGTCGGCAA AGCGCAGGTC GTGCAGCTGG 45180

TTGCGGCGCT GGACCTCCGT GTAGTCCAGC AGGCCGCTGT CCTTGATCTC GTGGCGCGTG 45240

TAGACCTCCA GGGGCACAAA CTCGTGGTCC TCCAGCATGG TGATGTTCAG GTCGATGAAG 45300

GTGCTGACGG TGGTGACGTC GGCGCGACTC AGCTGGTGAG AGTACGCGTA CTCCTCGAAG 45360 TACACGTAGC CCCCGCCGAA GATGAAGTAG CGCCGGTGGC CCACGGTGCA CGGCTCGAGC 45420

GCGTCGCGGG TGAGGCGCAG CTCGTTGTTC TCGCCCAGCT GCCCCTCGAT CAGCGGGCCC 45480

TGGTCTTCGT ACCGAAAGCT GACCAGGGGG CGGCTGTAGC ACGTCCCCGG CCGCGAGCTG 45540

ACGCGCATCG AGTTCTGCAC GATCACGTTG TCCGGGGCGA CGGGCACGCA CGTGGAGACG 45600

GCCATGACGT CTCCGAGCAT GCGCGCGCTC ACCCGCCGGC CGACGGTGGC GGAGGCGATG 45660 GCGTTGGGGT TGAGCTTGCG GGCCTCGTTC CAGAGAGTCA GCTCGTGGTT CTGCAGCTCG 45720

CACCACGCGA CGGCGATGCG CCCCAGCATG TCGTTCACGT GGCGCTGTAT GTGGTTATAC 45780

GTAAACTGCA GCCGGGCGAA CTCGATCGAG GAGGTGGTCT TGATGCGCTC CACGGACGCG 45840

TTGGCGCTGG GCGCCTCCCG CAGTGGCGCG GGCGTGGCAT TCCGGGGCTT GCGGTCCTGC 45900

TCCCGCATGT ACTCCCGCAC GTACAGCTCG GCGAGCGTGT TGCTGAGGAG GGGCTGGTAC 45960 GCGATGAGGA AGCCCCCCGT GGCCAGGTAG TACTGCGGCT GGCCCACCTT GATGTGCGTG 46020

GCGTTGTACT TGCGCGCAAA CATGCGGTCG ATGGCCTCGC GGGCATCCCG GCCAATGCAG 46080

TCGCCCAGGT CGACGCGCGA GAGCGAGTAC TGGGTCAGGT TGGTGGTGAA GGTGGTCGAG 46140

ATGGCGTCGG AGGAGAAGCG GAAGGAGCCG CCGTACTCGG CGCGGAGCAT CTCGTCCACC 46200

TCCTGCCACT TGGTCATGGT GCAGACCGCC GGTCGCTTCG GCACCCAGTC CCAGGCCACG 46260 GTAAACTTGG GGGTCGTCAG CAAGTTGCGG GTCGTCGGCG ACGTGGCCCG GGCCTTCGTG 46320

GTGAGGTCGC GCGCGTAGAA GCCGTCGACC TGCTTGAAGC GGTCGGCGGC GTAGCTGGTG 46380

TGCTCGGTGT GCGACCCCTC CCGGTAGCCG TAAAACGGGG ACATGTACAC AAAGTCGCCC 46440

GTCGCCAACA CAAACTCATC GTACGGGTAC ACCGACCGCG CGTCCACCTC CTCGACGATG 46500

CAGTTGACCG TCGTGCCGTA CCGATGGAAC GCCTCCACCC GCGAGGGGTT GTACTTGAGG 46560 TCGGTGGTGT GCCACCCCCG GCTCGTGCGC GTGGCGACCT TCGCCGGCTT GAGCTCCATG 46620

TCGGTCTCGT GGTCGTCCCG GTGAAACGCG GTGGTCTCCA TGTTGTTCCG CACGTACTTG 46680

GCCGTGGAGC GGCAGACCCC CTTGGCGTTA ATCTTGTCGA TCACCTCCTC GAAGGGAACG 46740

GGGGCGCGGT CCTCGAATAT CCCCATAAAC TGGGAGTAGC GGTGGCCGAA CCACACCTGC 46800

GACACGGTCA CGTCTTTGTA GTACATGGTG GCCTTGAATT TGTACGGGGC GATGTTCTCC 46860 TTGAAGACCA CCGCGATGCC CTCCGTGTAG TTCTGCCCCT CCGGGCGCGT CGGGCAGCGG 46920

CGCGGCTGCT CAAACTGCAC CACCGTGGCG CCCGTCGGGG GCGGGCACAC GTAAAACTGG 46980

GCATCGGCGT TCTCGACCTT GATTTCCCGC AGGTGCGCGC GCAGCGTGGC GTGGCCGGCG 47040

GCGACGGTCG CGTTGGCGTC GGGGGGCGGG GTCGCCTCGG GCCGCTTGGG CGGCTTTTTG 47100

GTTTTCCGCT TCCGGGCCTT GGTGGTCGCG GGGCTCGGGA CGGGGGGCGG CCGGGAGGCG 47160 GGACCCCCGT TCGCCGCGAC GGTCGCGGCC ACGCCGCCCG AGGCGCGGGG GGCCGCCGGG 47220

GCCGCCGGGG CCGCCGACGC CACCGCGGCC ACCAGCGCCC CCACGACCAG CGCGCAAATC 47280

AAGCCCCCCC CGCGCATGGC GGGCCTACGG GGGCGCGTCG CTCCCGCCGC CCGCTAGTCT 47340

GGGGGCGAGG TGCTGCAGGA CCGAGTAGAG GATGGAAAAA ACGTCTCGGT CGTAAACCAC 47400

GACCGAGCGG GGTCCGATGC AGCCGTCGGG GCCGCTCTCG ACGATGGCCA CCAGCGGACA 47460 GTCGGAGTTG TACGTGAGGT ACACGCCCGG CGGGTAGCGG TACAGACCTT CGGAGGTCGG 47520

GCGGCTGCAG TCGGGGCGGC GCAACTCAAG CTCCCCGCAC CGGTAGACCG ACGCAAAGAG 47580

TGTGGTGGCG ATAATGAGCT CGCGAATATA TCGCCAGGCG GCGCGCTGGG TGGGCGTGAT 47640

TCCGGAAACA CCGTCAAAAC AGTAGAACTT TTGAAACTCG CTGACGGCCC AATCAGCGCC 47700 CGAACCCCCC GCGCCCATGA TGAAGCGGGC GAGTTCCTCC TTGAGGTGCG GCAGGAGCCC 47760

CACGTTCTCG ACGCTGTAGT ACAGCGCGGT GTTGGGGGGC TGGGCGAAGC TGTGGGTGGA 47820

GTGGTCGAAC AGGGGCCCGT TGACGAGCTC GAAGAAGCGA TGGGTGATGC TGGGGAGCAG 47880

GGCCGGGTCC ACCTGGTGGC GCAGCAGCGA CGCTCGCATG AACCGGTGCG CGTCAAACAC 47940 GCCCGGGGCG GCGCGGTTGT CGATGACCGT GCCCGCGCCC GCCGTCAGGG CGCAGAAGCG 48000

CGCGCGCGCC GCGAAGCCGT TGGCGACCGC GGCGAAGGTC GCGGGCAGCA CCTCGCCGTG 48060

GACGCTGACC CGCAGCATCT TCTCGAGCTC CCCGCGCTGC TCGCGCACGC AGCGCCCGAG 48120

GCTGGCCAGC GACCGCTTGG TCAGGCGGTC CGCGTACAGC CGCCGGCGCT CCGGCACGTC 48180

CGCGGCGGCC CGCGTCGCGA TGTCGCCCCA GCTCTCCGGC CCCTGCGCCC CTGGCTCGGG 48240 GCCGCGCTCC CCGTCCTCGC TCGCGGGCGT CCCCGCGCCA CGCCTCCGCC CCCCCTCCTC 48300

CGCGGCGGCC CGGGGCTCTT CCTCCTCGGC CCCCCCGGTC GCGCCGCCGG CCCCCAGCCG 48360

CGCCAGCACG CGGCGCAGCG CCTCCTCGTC GCACTGCTCG GGGCTGACGA GCCGCCGCAG 48420

CAGCGGCGTC GTCAGGTGGT GGTCGTAGCA CGCGCGTATC AGCGCCTCGA TCTGATCGTC 48480

GGGCGACGTC GCCTGGCCGC CGATGATCAG GGCGTCCACC ATGTCCAGCG CCGCCAGGTG 48540 GCCCCCGAAC GCGCGATCGA AGTGCTCCGC CCGCCGCCCG AACAGCGCCA GCTCCACGGC 48600

CACCGCGGCG GTCTCCTGCT GCAGCTCGCG CTGCGCCAGC GCGTTCAGGT TGTCGGCGAA 48660

GGCGTCCATG GTGGAGTGGC GGGCGCGATC GCCGGACGCC AGCCAGAAGC GCAGCTCGCT 48720

GATGGCGTAC AGGCCGGGCG TAGTGGCCTG AAACACGTCA TGCGCCTCCA GCAGGGCGTC 48780

GGCCTCCTCG CGGACAGAAG AGCTATCGGC GGGCGGCGGG CCGGCCCGGG CCCCGCCGCC 48840 CGCCGCGGTC CGCGCCAGCG CCTGGTCCAG CACACAGAGC GCTCGCGCGC GGGCGGCGTC 48900

CGACAGCCCG GCGGCGTGGG GCAGGTACCG TCGCAGCTCG TTGGCGTCCA GCCGCACCTG 48960

GGCCTGTTGG GTGACGTGGT TACAGATGCG GTCCGCCAGG CGGCGGGCGA TGGTCGCCCC 49020

CTGGTTCGCG GTGACGCACA GCTCCTCGAA ACAGACCGCG CACGGGTGGG ACGGGTCGCT 49080

CAGCTCCGGG GGCACGATGA GGCCCGACCC CACCGCCGCC ACCATAAACT CCCGGACGCG 49140 CTCCAGCGCG GCCGTGGCGC CGCTCGGGGG GGTGATGAGG TGGCAGTAGT TCAGCTGCTT 49200

GAGAAAATTC TCGACATCAT GCAGGAAGCA CAGCTCCATG CGGACGTCCC CGCCGTACGT 49260

CTCCAGCCGG ATCTGCTGGT GGTACGGACA GGGTCGGGCC AGACCCATGG TCTCGGTGAA 49320

AAAGGCAGAG ACGTCACCCG TGGTCGCGAA CGTTTCCAGG TGGCCCAGGA GCCGCTCCCC 49380

CTCGCGCCAC GCGTACTCCA GGAGCAACTC CAGGGTGACC GACAGCGGGG TGAGAAAGGC 49440 GGCGGCCTGA GCCTCCAGCC CCGGCCGCAG GTGCCGCCGC AGCACGCGCA CCTGGAGCGC 49500

GTTGAGCTTT AGCTGGGCGA GCTTCCCCAG GCCGATCTGG GGGTCGCATC GTCGAAGCAG 49560

CTCTAGCTGA AAAACGTACG TCTGTACCTG CCCGAGCAGG GCCAACAGTT TCTGTCGGGC 49620

CGCAGTGGGC TCGGAAACCG CGGCCGGGGG CGCGGCCGCC ATGGCGAGTC GCCCGGCCGT 49680

GCTGTGGTTT AGTTAAGGTT TGGGGGGGTG GGTCAGAGGC GCGCCCCGCG CGGACTGATG 49740 CGGCGGCGGG CCCCTGACAT CCCCTCTTTA TGCCCGTCGC CCGCCCGCCC GCCCCGCCGG 49800

TGTGCCGTGA TTCGCGGAGT CGGGGCCTTG TGTTTCTTTC TTTCCCCCCC CGAATCCGTT 49860

CTTTCTTCCT CACCCCCCCT CCCCACACAC CCACCCAGGA CTCGCCACCA CAAGGAGGCG 49920

AGAGCCCGTC GCTAACCCAA AGACACAGTC ACGAGACACG ATATCGACTG TAGTTGCGAT 49980

CGTTTATTTT ATACACAACA CCAACCTTTC CTTCGACCCC CCCCACCCCC GCCCCTAGAG 50040 CATATCCAAC GTCAGGTCCT TTTTCTCCGG TGGTCCCTCC CCAAACGGAT CGTCGCCGTG 50100

AAACGCCCGC TTTCGGGCGA CGCCGGCCGC CCCCGCCGCC GCCGCCAAAC CGCCGAACGA 50160

CGCCGCGTGG TCATCCTCGT CGCCGAAATC CCCAAAGTTA AACACCTCCC CGGCGGCGCC 50220

GAGCTGGCTG ACCAGGGCCT CCGCCTCGTG GGCCACCTCC AGGGCCGCGT CGGTCGACCA 50280 CTCGCCGTGC CCGCGCTCCA GGGCGCGGGT GGTAAACTCC ATCATTTCCT CGCTCAGGTA 50340

CTCGTCCTCC AGCAGCGCCA GCCAGTCCTC GATCTGCAGC TGCTGGGTGC GGGGGCCCAG 50400

GCTCTTGACG GTCGCCACAA ACACGCTGCT GGCGACCGCC GCCCCGCCCT CCGCAATGAT 50460

GCCCCGGAGC TGCTCGCACA GCGAATGCTC GTGGGCCCCG CCCCCGAGAC TCGACGCCGC 50520 GCACACAAAC CCGGCCCTGG GGCAGGCCAG GACAAACTTG CGGGTGCGGT CAAAGATCAG 50580

CAGCGGGCAC GCGTTTTTGC CGCCCAGCAG GCTGGCCCAG TTCCCGGCCT GAAACACGCG 50640

GTCGTTGCCG GCCATGCCGT AGTATTTGCT GATGCTGAGG CCCAGCACGA CCATCGGGCG 50700

CGCGGCCATC ACGGGCCGCA GCAGGTTGCA GCTCGCGAAC ATGGACGTCC AGGCGCCGGG 50760

GTGCGCGTCG AGGGAGTCCA TCAGCGCGCG GGCCCCGGCC TCCAGGCCCG CGCCGCCCTG 50820 CGGGGCCCAG GCGGCGGCCG CCTGCACGCC GGGGGGACGG CGGGACCCGG CGATGACGGC 50880

CGTGAGGGTG TTTATGAAGT ACGTCGAGTG GTCGCAG AC CTCAAGATCT GGTTGGCCAT 50940

GTAGTACATG GCCAGTTCGC TCACGTTATT GGGGGCCAGG TTGATAAAGT TAATCGCGCC 51000

GTAGTCCAGG GAGAACCTCT TAATGAACGC GATGGTCTCT ATGTCCTCGC GCGACAAGAG 51060

CCGGGCGGGG AGCTGGTTGC GCTGGAGGGC GGTCCAGAAC CACTGCGGGT TCGGCTGGTT 51120 CGACCCCGGG GGCTTGCCGT TGGGAAAGAT GACCGCGTGG AACTGCTTCA GCAGGAAGCC 51180

CAGCGGTCCG AGGAGGATGT CCACGCGCTT GTCGGGCTTC TGGTAGGCGC TCTGGAGGCT 51240

GGCGACCCGC GCCTTGGCGG CCTCGGACGC GTTGGCGCTC GCGCCCGCGA ACAACACGCG 51300

GCTCTTGACG CGCAGCTCCT TGGGAAACCC CAGGGTCACG CGGGCAACGT CGCCCTCGAA 51360

GCTGCTCTCG GCGGGGGCCG TCTGGCCGGC CGTTAGGCTG GGGGCGCAGA TAGCCGCCCC 51420 CTCCGAGAGC GCGACCGTCA GCGTCTTCGC CGACAGGAAC CCGTTGTTGA ACAGGTCCAT 51480

GACGCGCCGC CGCAGCACCG GTTGGAATTG ATTGCGAAAG TTGCGCCCCT CGACCGACTG 51540

CCCGGCGAAC ACCCCGTGGC ACTGGCTCAG GGCCAGGTCC TGGTACACGG CGAGGTTGGA 51600

CCGCCGCGCG AGGAGCTGCA GCAGGGGGCA CGGCCCGCAG GTGTACGGGT CCAGCGACAG 51660

CGACATGGCG TGGTTGGCCT CGGCCAGACC GTCGCGGAAC TTAAACCAGC TGCTTGATGT 51720 TGTTCACCAC CGTGTGCAGG GCCTCGCGGG TGCCGATAAT CGTCTCCAGC CTCCCCAGGG 51780

CCGTGGGCAC CGCCTGGTCC ACGTACTGCA GGGCCTCGAG CTCGGCCATG ACGCGCTCGG 51840

TGGCCGCGCG GTACGTCTCC TGCATGATGG TCCGGGTGTT CTCGGACCCG TCCGCGCGCT 51900

TCAGGGCCGA GAAGGCGGCG TAGTTCCCCA GCACGTCGCA GTCGCTGTAC GCGCTGTTCA 51960

TCGTTCCGAA GACCCCAATG GCCCCCCGGG CGGCGCTCGC GAACTTGGGG TGGCGGGCCC 52020 GCAGCCGCAT CAGCGTCGTG TGCGCGCAGG CGTGGCGGGT CTCGAAGGTA CACAGGTTGC 52080

AGGGCACGTC GGTCTGGCCC GAGTCCGCGA CGTAGCGAAA CACGTCCATC TCCTGGCGCC 52140

CGACGATGAC TCCGCCGTCG CAGCGCTCCA GGTAAAACAG CATCTTGGCC AGCAGGGCCG 52200

GAGAGAACCC GCACAGCATG GCCAGGTGCT CGCCGGCGAA CTCCTGGGTT CCGCCGACGA 52260

GGGGCGCCGT GGGGCGCCCC TCGTACCCGG GCACCACGTG GCCCTCGCGG TCCAGCTGCG 52320 GGTTGGCCGC CACGTGCGTG CCGGGCACGA GAAAGAAGCG GTAAAAGGAG GGCTTGCTGT 52380

GGTCCTTGGG GTCCGCCGGC CCGGCGTCGT CCACCTCGGT CAGGTGGAGG GCCGAGTTGG 52440

TGCTGAACAC CATGGCGCCC ACGAGGCCCG CGGCGCGCGC CAGGTACGCC CCGACGGCGC 52500

CGGCACGGGC CGCGGGCGTT TCCTGGCCCT CAAGCAGGGG CCACGTGGTG ATGTCGGGGG 52560

GCGGCTCGTC AAAGACCGCC ATCGACACGA TGGACTCCAG GGCCAGGGCG GCGTCGCCCG 52620 CCATCACCGA GGCCAGGCGC TGCTCAAACC CGCCCGCCGG GCCCTTGTTC CCGGCGTCGC 52680

GCGCGCCCCG CTGGGGCTTA CCCTGGCTGG CCTCGAAGGC CGTGAACGTA ATGTCGGCGG 52740

GGAGGGCCGC GCCCTCGTGG TTTTCGTCGA ACGCCAGGTG GGCGGCCGCG CGGGCCACGG 52800

CGTCCACGTT CCGAGCACGC AGGGCCACGG CGGCGGGCCC GACGACCGCC TCGAACAGCA 52860 GGCGGGCGAG GGGGCGGTTG AAAAACGGAA GGGGGTAGTT GAAATTCTCC CCGATCGATC 52920

GGTGGTTGCA GTTAAACGGA TCGGCGATGA CCCGGCTAAA ATCCGGCATA AACATCTGCA 52980

GCGGATACAC GGGGATGCGG TGAACCTCCG CGTCCCCGAT GGTTACCTTG TCCATCCCGC 53040

CCAGGTGCAG GAAGGTGTTG CTGATGCACA CGGCCTCCCG GAAGCCCTCC GTGATCACCA 53100 GATACAGCAA GGCCCGGTCC GGGTCCAGTC CGAGCCGCTC GCACAGCGCG TCCCCCGTCG 53160

TCTCGTGCTT TAGGTCGCAG GGCCGGGGCG CGTAGTCCGA GAAGCCAAAA TGGCGGCGCG 53220

CCCGCTCGCA GAGCCGCGTC AGGTTGGGGG CCTGGGTGCT GGGGGCCAGG TGGCGGCCGC 53280

CGTGAAAGAC GTAGACGGAC GGGCTGTAGT GCGAGGGCAT AAGCTTGAGG GACACCGCGG 53340

TCCCCCCAAG GCCCGTCGTG CGGGACCCGA CGACCGCGGC CACGTTGGCC TCAAACCCGC 53400 TCTCCACGGT CAGGCCGACG ATGAGGGGCG CGACGGCGAC GTCCGCGTCG CCGCTGCGCG 53460

CCGACAGTAG CGACAGCAGC TCCAGGCCTT CGGCCGGACA GGCGCGGCCA TACACGTACC 53520

CCATCGGCCC CGGAGGAACC TTGACGGTGG TCGTCGTTTT GGGCTTGGTG TCCATGGCTT 53580

TCGGGAGATT GGCGACCGGC AGGAACGGGG GCCCGGCAAG ACGACCGGGG GCAGACGGGG 53640

GAGGCCGCGC GTGGTCGACG GCTGCTGCCC GCCGTCGTCT CTCCGATGGG GTCGAATGCC 53700 GGCGCTGGGG GTGGGGTCTA CACCCGCCCG TTCACCGAGC GGCCCCTGGT GGGGGTGGGA 53760

TGGGTGGGAT GGGGTGGGCG AGAATGGCCC GCCACCGGAT CGCGCCGGAC GGGGGGGCCC 53820

GGGGTTGGGC AAGGTTTGGG CGCAAGGCTC CAGCGGCGAT TCGAGAGGCC TGCGGATGGC 53880

GGCCCAGAGC TGGGTATGCT CGGCCGGGGC GGCCGGTATA TGTACGGCGT GCTGGGAGGG 53940

GCGGCGTCGG GCCCCGCCCA CGGTCCGCCA CGCCCCGCGC GTCATCGGCA GGGGGCGTGG 54000 CCGCCCTTCT AAAAAAAGTG AGAACGCGAA GCGTTCGCAC TTTGTCCTAA TAGTATATAT 54060

ATTATTAGGA CAAAGTGCGA ACGCTTCGCG TTCTCACTTT TTTTAGAAGG GCGGCCACGC 54120

CCCCTTTGAC GTCACGCTCA CCCGGGCGGC CGGCCGCCCA TAAGCGCGGC CTGCCGGGCC 54180

GATAAAAAGA AACCGCGGCG CCCCCGCGGA CACCACACAC TGGCTCTCGA ACCCCGGACG 54240

CGCAGAAGGG ACCCGGGCGC GGGTCCGCCG GTAAGAGCCG GGGGGAACAT CGGCACCGCC 54300 ATCCCACCCC GAGCTGTTGG GTGGGCGGGT GGGGGGGCTG GTGAGGCGGT GGTGGGAGGG 54360

GGCGGCGTAT AGCAGGACAA CGACCGGCGG CGATGTTTTG TGCCGCGGGC GGCCCGACTT 54420

CCCCCGGGGG GAAGTCGGCG GCTCGGGCGG CGTCTGGGTT TTTTGCCCCC CACAACCCCC 54480

GGGGAGCCAC CCAGACGGCA CCGCCGCCTT GCCGCCGGCA GAACTTCTAC AACCCCCACC 54540

TCGCTCAGAC CGGAACGCAG CCAAAGGCCC CCGGGCCGGC TCAGCGCCAT ACGTACTACA 54600 GCGAGTGCGA CGAATTTCGA TTTATCGCCC CGCGTTCGCT GGACGAGGAC GCCCCCGCGG 54660

AGCAGCGCAC CGGGGTCCAC GACGGCCGCC TCCGGCGCGC CCCTAAGGTG TACTGCGGGG 54720

GGGACGAGCG CGACGTCCTC CGCGTGGGCC CGGAGGGCTT CTGGCCGCGT CGCTTGCGCC 54780

TGTGGGGCGG TGCGGACCAT GCCCCCGAGG GGTTCGACCC CACCGTCACC GTCTTCCACG 54840

TGTACGACAT CCTGGAGCAC GTGGAACACG CGTACAGCAT GCGCGCCGCC CAGCTCCACG 54900 AGCGATTTAT GGACGCCATC ACGCCCGCCG GGACCGTCAT CACGCTTCTG GGTCTGACCC 54960

CCGAAGGCCA TCGCGTCGCC GTTCACGTCT ACGGCACGCG GCAGTACTTT TACATGAACA 55020

AGGCAGAGGT GGATCGGCAC CTGCAGTGCC GTGCCCCGCG CGATCTCTGC GAGCGCCTGG 55080

CGGCGGCCCT GCGCGAGTCG CCGGGGGCGT CGTTCCGCGG CATCTCCGCG GACCACTTCG 55140

AGGCGGAGGT GGTGGAGCGC GCCGACGTGT ACTATTACGA AACGCGCCCG ACCCTGTACT 55200 ACCGCGTCTT CGTGCGAAGC GGGCGCGCGC TGGCCTACCT GTGCGACAAC TTTTGCCCCG 55260

CGATCAGGAA GTACGAGGGG GGCGTCGACG CCACCACCCG GTTTATCCTG GACAACCCGG 55320

GGTTTGTCAC CTTCGGCTGG TACCGCCTCA AGCCCGGCCG CGGGAACGCG CCGGCCCAAC 55380

CGCGCCCCCC GACGGCGTTC GGAACCTCGA GCGACGTCGA GTTTAACTGC ACGGCGGACA 55440 ACCTGGCCGT CGAGGGGGCC ATGTGTGACC TGCCGGCCTA CAAGCTCATG TGCTTCGATA 55500

TCGAATGCAA GGCCGGGGGG GAGGACGAGC TGGCCTTTCC GGTCGCGGAA CGCCCGGAAG 55560

ACCTCGTCAT CCAGATCTCC TGTCTGCTCT ACGACCTGTC CACCACCGCC CTCGAGCACA 55620

TCCTCCTGTT TTCGCTCGGA TCCTGCGACC TCCCCGAGTC CCACCTCAGC GATCTCGCCT 55680 CCAGGGGCCT GCCGGCCCCC GTCGTCCTGG AGTTTGACAG CGAATTCGAG ATGCTGCTGG 55740

CCTTCATGAC CTTCGTCAAG CAGTACGGCC CCGAGTTCGT GACCGGGTAC AACATCATCA 55800

ACTTCGACTG GCCCTTCGTC CTGACCAAGC TGACGGAGAT CTACAAGGTC CCGCTCGACG 55860

GGTACGGGCG CATGAACGGC CGGGGTGTGT TCCGCGTGTG GGACATCGGC CAGAGCCACT 55920

TTCAGAAGCG CAGCAAGATC AAGGTGAACG GGATGGTGAA CATCGACATG TACGGCATCA 55980 TCACCGACAA GGTCAAACTC TCCAGCTACA AGCTGAACGC CGTCGCCGAG GCCGTCTTGA 56040

AGGACAAGAA GAAGGATCTG AGCTACCGCG ACATCCCCGC CTACTACGCC TCCGGGCCCG 56100

CGCAGCGCGG GGTGATCGGC GAGTATTGTG TGCAGGACTC GCTGCTGGTC GGGCAGCTGT 56160

TCTTCAAGTT TCTGCCGCAC CTGGAGCTTT CCGCCGTCGC^' GCGCCTGGCG GGCATCAACA 56220

TCACCCGCAC CATCTACGAC GGCCAGCAGA TCCGCGTCTT CACGTGCCTC CTGCGCCTTG 56280 CGGGCCAGAA GGGCTTCATC CTGCCGGACA CCCAGGGGCG GTTTCGGGGC CTCGACAAGG 56340

AGGCGCCCAA GCGCCCGGCC GTGCCTCGGG GGGAAGGGGA GCGGCCGGGG GACGGGAACG 56400

GGGACGAGGA TAAGGACGAC GACGAGGACG GGGACGAGGA CGGGGACGAG CGCGAGGAGG 56460

TCGCGCGCGA GACCGGGGGC CGGCACGTTG GGTACCAGGG GGCCCGGGTC CTCGACCCCA 56520

CCTCCGGGTT TCACGTCGAC CCCGTGGTGG TGTTTGACTT TGCCAGCCTG TACCCCAGCA 56580 TCATCCAGGC CCACAACCTG TGCTTCAGTA CGCTCTCCCT GCGGCCCGAG GCCGTCGCGC 56640

ACCTGGAGGC GGACCGGGAC TACCTGGAGA TCGAGGTGGG GGGCCGACGG CTGTTCTTCG 56700

TGAAGGCCCA CGTACGCGAG AGCCTGCTGA GCATCCTGCT GCGCGACTGG CTGGCCATGC 56760

GAAAGCAGAT CCGCTCGCGG ATCCCCCAGA GCACCCCCGA GGAGGCCGTC CTCCTCGACA 56820

AGCAACAGGC CGCCATCAAG GTGGTGTGCA ACTCGGTGTA CGGGTTCACC GGGGTGCAGC 56880 ACGGTCTTCT GCCCTGCCTG CACGTGGCCG CCACCGTGAC GACCATCGGC CGCGAGATGC 56940

TCCTCGCGAC GCGCGCGTAC GTGCACGCGC GCTGGGCGGA GTTCGATCAG CTGCTGGCCG 57000

ACTTTCCGGA GGCGGCCGGC ATGCGCGCCC CCGGTCCGTA CTCCATGCGC ATCATCTACG 57060

GGGACACGGA CTCCATTTTC GTTTTGTGCC GCGGCCTCAC GGCCGCGGGC CTGGTGGCCA 57120

TGGGCGACAA GATGGCGAGC CACATCTCGC GCGCGCTGTT CCTCCCCCCG ATCAAGCTCG 57180 AGTGCGAAAA AACGTTCACC AAGCTGCTGC TCATCGCCAA GAAAAAGTAC ATCGGCGTCA 57240

TCTGCGGGGG CAAGATGCTC ATCAAGGGCG TGGATCTGGT GCGCAAAAAC AACTGCGCGT 57300

TTATCAACCG CACCTCCAGG GCCCTGGTCG ACCTGCTGTT TTACGACGAT ACCGTATCCG 57360

GAGCGGCCGC CGCGTTAGCC GAGCGCCCCG CAGAGGAGTG GCTGGCGCGA CCCCTGCCCG 57420

AGGGACTGCA GGCGTTCGGG GCCGTCCTCG TAGACGCCCA TCGGCGCATC ACCGACCCGG 57480 AGAGGGACAT CCAGGACTTT GTCCTCACCG CCGAACTGAG CAGACACCCG CGCGCGTACA 57540

CCAACAAGCG CCTGGCCCAC CTGACGGTGT ATTACAAGCT CATGGCCCGC CGCGCGCAGG 57600

TCCCGTCCAT CAAGGACCGG ATCCCGTACG TGATCGTGGC CCAGACCCGC GAGGTAGAGG 57660

AGACGGTCGC GCGGCTGGCC GCCCTCCGCG AGCTAGACGC CGCCGCCCCA GGGGACGAGC 57720

CCGCCCCCCC AGCGGCCCTG CCCTCCCCGG CCAAGCGCCC CCGGGAGACG CCGTCGCATG 57780 CCGACCCCCC GGGAGGCGCG TCCAAGCCCC GCAAGCTGCT GGTGTCCGAG CTGGCGGAGG 57840

ATCCCGGGTA CGCCATCGCC CGGGGCGTTC CGCTCAACAC GGACTATTAC TTCTCGCACC 57900

TGCTGGGGGC GGCCTGCGTG ACGTTCAAGG CCCTGTTTGG AAATAACGCC AAGATCACCG 57960

AGAGTCTGTT AAAGAGGTTT ATTCCCGAGA CGTGGCACCC CCCGGACGAC GTGGCCGCGC 58020 GGCTCAGGGC CGCGGGGTTC GGGCCGGCGG GGGCCGGCGC TACGGCGGAG GAAACTCGTC 58080

GAATGTTGCA TAGAGCCTTT GATACTCTAG CATGAGCCCC CCGTCGAAGC TGATGTCCCG 58140

CATCTTGCAA TAAATGTCTG CGGCCGACAC GGTCGGAATT TCCGCGTCCG CTGGTTTCTC 58200

TGCGTTGCGT CTGACCACGA GCACAAACGT GCTCTGCCAC ACGTGGGCGG CGAACCGGTA 58260 GCCGGGGCAC GCGGTCAGCA TCCGATCGAT GAGCCGGTAG TGCAGGTGGG CCGACGTGCC 58320

GGGGAAGATG ACGTACAGCA TGTGGCCCCC GTACGTGGGG TCCGGGTAAA AAAGAAACCG 58380

GGGGTCGCAC GCCCCCCCTC CGCGCAGGAT CGTGTGCACG AAAAAGAGCT CGGGCTGGCC 58440

GAGCGTATCG GCCAGGAGGT CCTGGAGGGG GGTGCTGTGG CGGTCGGCCA GCACGACCAG 58500

GGAGGCCAGA AAGGTGCGGT GCTCAAAGAT CGTATTGATC TGCTGCACGA AGGCCAGGAT 58560 GAGGGCCTCG CGGCTGACGG TGGCCAGCCG CCCGTCGCCC GCGCTGCACG CGGGGCAGCA 58620

GCCCCCGATC CCCAGGTAGT AGCCCATGCC CGAGAGGGTC AGGCAGTTGT CGGCCACGGT 58680

CTGGTCCAGG CTGAAGGGGA GCGACACGGG GGTCGTCTTC ACCAGGGGCA CGGATAGCGA 58740

GCGCACGATG GCGATCTCCT CGGAGGGCGT CTGGGCGAGG GCGGCGAAGA AGCCGCGGTA 58800

GCGACGGCGC TCGTGCAGGC AGAGCTCCAG CCTGCGCGCG TGCGACGGCA GGCTCTTGCG 58860 GGAGGCCCGG CGCTCCACGC CGGGGTTCCC GGCGGCGGAA AAGCGCGACC GCCGCCGGGT 58920

CTTGTCGCGG CCGGGCCCGG GCCGGGAGCC GGAGCGACGG GGGGCGATGT CATACATAGG 58980

TACAGAGGGT GTGCTCCAGG GACAGGAGAG AGATCGAGTG TCGTCTGAGC AGCGCGCCGG 59040

CCTCGCGGAC AAATGTGGCC AGCGCGGTGG GCTTCGGCAC AAATACCTGG TACGTCTTGA 59100

AGGTGTAGAT GAGGGCCCGC AGGGCTATAC AGACCCGCCC CTCGAACTCG TTGCCGCAGG 59160 CCAACTTGGC CTTGTGAAGC TGCAGCTCGT CGCGATGGTC GGCGCGGGGG TGGCCAAACA 59220

GGACCCAGGG GTCGACTTCC ATCTCCGTGA TGGCGCACAT GGGATCGCAG AACATGTGCT 59280

TGAAGATGGC CTCGGGGCCC GCGGCCCGAA GCAGGCTCAC GAACCGGCCC CCGTCCCCGG 59340

GCTGCGCCTC GGGGTCCGCC TCGAGCTGGT CCACGACCGG CACTATGCAG TCGAAGAGGC 59400

TGGTGTTGTT CTCCGAGTAG CGGACGACGG ACGCCCTCAG GCGTCGCATG GCCAGCCAGT 59460 AGGCCCGCAC CAGCAACAGA TTGCACAGCA GGCATTCCCC GCCGGTGCGC CCGCGGCCCC 59520

GGCCGTGCTT CAGCACGGTG GCCATCAGCG GGCCCAGGTC CAGGTCGGGC TGGGCCTTGG 59580

GCTCGGCGAA CTGCGCAAAG CGCGGGGCCG CGTCGCGCAT GCGCGCCCCG CGGTGCGCTT 59640

CCCAGGACTC GCTGACCGCG GCGCGGCGGG CGTCCGCGGC GGCGCGCAGC CGGGGCCCCG 59700

ACTCCCAGAC GGCGGGGGTG CCGGCGAGCA GCAGCAGGAT CAGGTCGGCG TACGCCCACG 59760 TCTCCGGCTC ACCCCCCTGC GCCAGCGCCC CGGCGGCGGC CTCGAACTCC CCGTTGCGGG 59820

CGGCGGCGCG CGTGCAGCAG CTGTCTCCGC CCCCGCGCTT GCCCTCGGTG CAGTCGAGCA 59880

GGCGGGCGCA GTCCTTCCAG TTCATCAGGG CGGTGGTGAG GGAGGGTTGC GTTCCCGAGC 59940

CCCCGCCCGC CCCCGCCCCG TCATCGCCCC CGGAGGCCAG GGTCCCGATG AGGGCCCGGG 60000

TTGCGGACTG CGCGAGGAAG GAATAGTTGG AGTACTGCAC CTTGGCGGCG CCCGGGGAGG 60060 GCGTCGGCCT GGGTTGCTTC TGGGCGTGGC GCCCGGGCAC CCCGCCGTCG GTCCGGAAGC 60120

AGCAGTGGAG AAAGAAATGC CGGTGGATGT CGTTGATGGT CAGGGCGAAG CGCGCGAAGG 60180

AGCCGACAAG GGTCGCCTTC TTGGTGCGCA GGAAGTGGTG GTCCATGACG TAGACGAACT 60240

CGAAGGCGGC CACGAAGATG CTCGCGGCGC AGTGGGGCGC GCCCAGGCAC TTGGCGCAGA 60300

GGAACGCGTA ATCGGCCACC CACTGGGGCG AGAGGCGGTA GGCCTGCTTG TACAGCTCGA 60360 TGGTGCGGCA GACCAGACAG GGGCGGTCCA GCGCGAAGGT GTCGACGGAC GCCGCGGCGA 60420

AGGGCCCCGT GTCCAAGAGT CCCTCTGCCG TGGGGTCTGC GGGCGGGCCG CGGGCGGACC 60480

CCGGCCCCCG CCCCCCCGAA GCCTCGCGCG CGGCCCCGCG CGGCCGCGGG GGGGCGGGCG 60540

CGACGTCGCT CTCCACGTCC TCGTCGAGCG CGCTCGCGGG CGGCACGCCT ACCACGTGAC 60600 AGGCCGCCAG GAGCTCGGCG CACAGGGCCT CGTTAAGAGC CAGAAGGTCG GGATCGAAGG 60660

CCACATACGG ACGCTCGAAC GCGCCCTCCT TCCAGCTGCT GCCCGGCGAC TCTTCGCGCA 60720

CGGCGGCGCT CGACGGCACC CCCGGGGCGG ACGTCGCCAT GGCCGGTCGA GCGGGGCGCA 60780

CGCGTCCGCG AACGTTACGG GACGCGATCC CCGACTGCGC GCTGCGGTCC CAGACCCTGG 60840 AAAGTCTAGA CGCGCGCTAC GTCTCGCGAG ACGGCGCGGG GGACGCGGCC GTCTGGTTCG 60900

AGGACATGAC CCCCGCCGAA CTAGAGGTTA TATTCCCGAC CACGGACGCC AAGCTGAACT 60960

ACCTCTCGCG GACGCAGCGG CTGGCCTCCC TCCTGACGTA CGCCGGGCCT ATAAAAGCGC 61020

CCGACGGCCC CGCCGCCCCA CATACGCAGG ACACCGCGTG CGTGCACGGC GAGCTGCTCG 61080

CCCGAAAGCG CGAACGGTTC GCGGCGGTCA TTAACCGGTT CCTGGACCTG CACCAGATCC 61140 TGCGGGGCTG ACGCGCGCTT CGGCGGGGCA CCGGCACCGG GACCGACTTG TTTTACATAA 61200

CAGTAGGGGG TGGGGGAACG CGCACCCTTG CCCGGTCGCG ATGGCGGGGA TGGGGAAGCC 61260

CTACGGCGGC CGCCCGGGGG ACGCGTTCGA GGGTCTCGTT CAGCGCATCA GGCTCATTGT 61320

TCCCACCACG CTGCGCGGCG GGGGTGGGGA GTCGGGCCCC TACTCGCCAT CCAACCCGCC 61380

CTCGAGATGT GCCTTCCAGT TCCACGGCCA GGATGGGTCC GACGAGGCCT TCCCGATCGA 61440 GTACGTCCTG CGGCTCATGA ACGACTGGGC CGATGTGCCC TGCAACCCCT ACCTGCGCGT 61500

GCAGAACACC GGCGTTTCGG TGCTGTTTCA GGGGTTTTTT AACCGGCCCC ACGGCGCCCC 61560

GGGGGGCGCG ATCACGGCGG AGCAGACCAA CGTGATTCTG CACTCCACCG AGACGACGGG 61620

ACTGTCCCTC GGAGACCTGG ACGACGTCAA GGGGCGCCTC GGCCTGGACG CCCGGCCGAT 61680

GATGGCCAGC ATGTGGATCA GCTGCTTTGT GCGCATGCCC CGGGTGCAGC TCGCGTTTCG 61740 GTTCATGGGC CCCGAGGACG CCGTTCGCAC GCGGCGGATC CTGTGTCGCG CCGCCGAGCA 61800

GGCCCTCGCC CGTCGCCGCC GGTCCAGGCG GTCCCAGGAT GACTACGGGG CGGTGGCGGT 61860

GGCGGCGGCG CACCACTCTT CCGGAGCGCC CGGGCCGGGG GTCGCCGCCT CGGGCCCGCC 61920

AGCGCCGCCC GGACGGGGAC CGGCCCGTCC GTGGCATCAG GCCGTGCAGT TGTTCCGGGC 61980

CCCGCGTCCG GGCCCCCCGG CGCTTCTGTT GCTGGTGGCG GGGCTGTTTC TGGGGGCCGC 62040 TATCTGGTGG GCGGTTGGCG CGCGCCTATG AAAGGGGGCG AGCCACCGTC CCGCCCGCCA 62100

GTGCATCCCA GACGCCCGCG AGCCGCACAT CCCCTCCGCT CCCGCCTCCG GCCCGATTCT 62160

TACGGCGCGA CCCAAGGTCC CGATGGCCGC CCCGCAGTTT CACCGCCCCA GCACCATTAC 62220

CGCCGACAAC GTCCGGGCGC TCGGCATGCG CGGGCTCGTG TTGGCCACCA ACAACGCTCA 62280

GTTCATCATG GATAACAGCT ACCCGCATCC GCACGGAACG CAGGGTGCGG TGCGAGAGTT 62340 TCTTCGCGGG CAGGCCGCGG CGCTGACGGA CCTCGGGGTG ACCCACGCCA ACAACACGTT 62400

CGCCCCGCAG CCTATGTTCG CGGGCGACGC CGCGGCCGAA TGGCTGCGGC CCTCGTTCGG 62460

TCTTAAGCGC ACGTATTCCC CCTTTGTCGT TCGCGACCCC AAGACCCCCA GCACCCCGTG 62520

AGTCCTCGGC GGGTCCCTCC GCGGCCGTCT CTCGTTGCCC CCCCTTTCCC CCTTCCCGGG 62580

TGGTTCAATA AAAAACACCA ACATACGATA TTCGCGTTTG ATACGTTTAT TGGGGGGGTG 62640 TAGGGCCCAA CGATCGGCGA TTAACAACAC CAAACAATCG AGCGCGTCTA ACCCAGTAAC 62700

ATGCGCACGT GATGTAGGCT GGTCAGCACG GCGTTGCTGC GCTGAAACAG CGCCCTGCGG 62760

GTCCGCTGCA GCTGTTGTTG TATGCGGCGG CATGCGCGGA TCAAAACCGC CAGGGCGCTA 62820

CGACCGGTGC TTCGTACGTA GCGTCGCGAC AAGACGGCAT TTGCCTGTAC GGGCAAGGGG 62880

CCAAATTGCG AGTGTGGTGA CTGGAGGTGG TCGGCGGCCA ATGGGCCGGG TGGTTCGTCG 62940 GCGGGGGGCA AGTGCGGTTC CGGTGGGAGG GGGTCGAGCG CCTCGGTATC ATCCGAGTCC 63000

GAGAAACGCA GGGAGTCTGC GTCGGAGTGT TCATCATCGG AGGAGATGTG CAGCGTCTGA 63060

AGCAGCGATG CGGGTGGGGG CGCGGAGTCG ACGTGAAGCG CGAGAGAGGA AGCCCACGAA 63120

GTCACAGCGG ACACTGGGAG GTGGGTGTTT GTATGTGTGG GAGACTCGGG CGTCGGGACC 63180 GAGTCTCGGC TCTGGGGCAG GGGCGGCTGG GGCAGGGGCG GCTGGGGCAG GGGCGGCTGG 63240

GGCAGGGGCG GCTGGGGCAG GGGCGGCTGG GGCAGGGGCG GCTGGGGCAG GGGCGGCTGG 63300

GGCAGGGGCG GCTGGGGCAG GGGCGGCTGG GGCAGGGGCG GCTGGGGCAG GGGCGGCTGG 63360

GGCAGGGGCG GCTGGGGCAC CGAGCGCGCG CGGATGCGCG TCCGCGCGGC GGGTTTGGTC 63420 GCGGGTGACT GGGGTGGGGG GCGGCGGGCA ACCGGGCCTC CGGGCACGAC CCAACCGCAC 63480

AAAGGCTCGC TCGGGGCAAC CGGGCCTGGG GCCAAAGGCG GGGGGCTGGT CTGGACGGCG 63540

GAGGTCGGGG GGGCAAGGCC CGGAGAAGGC GGCACTGCCG CCGCTGCGGC GGAAACCGCG 63600

GCCGCGTGGT CGGCTGGGTC CCGGGGAGAG GGGAGGGAGT TCAACGAGGC CGAGAGCGAG 63660

GCGACCGCGG GGCGCGTGAG GCGCCGGGGT GGGCCGGCCG CGGGGCCCCG GGGGGGTGTC 63720 GGCGAGGGAC CCGCTGTTGT CTGGCGGCGG CCGCGGCGGC GGTCGTCCCC GGGGGCGACC 63780

GCTCCTTCGG CGGGCGGAGG CGGGATGGGC GCGAGCGTGG GGGCGGGAAA GGCCCCGCGA 63840

GCCGAGGCGG GGCCGGGCGG AAGGGGCAAA GCAGAAACCC AAGCCGGGGG CGCGGACTCC 63900

GGGGTGGGCG GCTGGTCGGG AGGACGCGCG GAAGCGGCGA CCGGGGCGAC CGGGGCGGGG 63960

AGTGCCGGCG GACGCCACCC CTCGGGGGGG GCGGAGGCCC GGGGCGCGCG CGATTTGGCA 64020 CGCGTCCGGC GGGATCTGCG CACGCGCGGC ACGGCGGCGG AGAAAGCGGC GGCAGAGCCG 64080

GAAAAGGCCG GGGGAGGAAG CGCGGCATCC GCGGGGGGAC TCGGTGTGGG TGGCGAGGGC 64140

CGTGGGTCGT CGCGAGGGGC CACGGGCACG CGCCCCGTGT TTTGTTGAGG CGGGACACTC 64200

GGTCGTGTTT CGCGAGCCGT AGCTGCCGGC CCGATGGGCC GCGGTGCGTA CTGGGACGTG 64260

GGGACGGACT GATCGGTGGC GGGGGGGGGA AGAAGGGCCG GGGCCGGATT GGGCGTGGGG 64320 CCGCCGGCGT CGTCGGACGC CAGCTCCTCC AGGCCGTGGA TCCAGGCCCA CATGCGAGGG 64380

GGGACGGGCT CGCCGGTGGT GGCGTCGGTG AGGAGAGTGG GGGCGAGGAC CCCCGGGTCC 64440

GCCTGCCGCG CGGGGGGGGC AGCGGGGTCC TCGGGACCCG ATCCGCCATC CCCCCCCGCA 64500

AGGTCCCGCG GGTCGCGGGC GGCGGTCGGG GCAGAGGGAC CTGCCTCGTC GGCGAGGGGG 64560

CGCTGGTAAA CCGGGTGTCC CGGGAACAGC TCCCCCGTCA GGAGGGAGGC GTCGAAGGGC 64620 CGCCCGAGGA TGGCCCGCGC GAAGAAGGGG TCCGCGTCGG CGGCGCTCGC CGCGAGAACG 64680

TCCCCCGCGG TAGCCACAAA CGGAAGCTCC TCGGTGGCCT CGCTGCCCAC AAACCGCACG 64740

TCAGGGGGGC CGGGGGGCTC CGGGGCTTCC CACAAGACCG CGACCGGGGT CATGGAGATG 64800

TCCACGAGGA CCAGGCACGG GGGCCCGTCG GCGAGAGGGC GCTCGGCGAT GAGCGCCGAC 64860

AGGCGCGGGA GCTGCGCCGC CAGACACGCG TTTTCGATCG GGTTGAGATC GGTGTGGAGG 64920 AGGCCGACGG CCCACGTCTC GATGTCGGAC GACACGACGT CGCGCAGGGC GGCGTCCGGC 64980

CCGCCGGGGC GCGAGTCGAA GAGCGTCAGG CACAGTTCCA GTTCCGACTC GCGGGAGAAG 65040

GCCGTGGTGT TGCGGAGCGC CACCACGACG GGCGCGCCGA GGAGCACCGC GGCCAGAACC 65100

AGGTCCATGG CCGTAACGCG CGCGGCGGGG GTGCGGTGGG TCGCGGCGGC CAGCACGGCC 65160

ACGTGCTGGC CCGTGGGTCG GTAGAGGGCG TGGGGGGCCT CGGGGAGGGA CGCCTCGCGC 65220 CCCCCCGCCG GGCCGAGCGT CTGGCCAGAC TCCAGGCGTG CGGCCAGGAG GGCGTCGAAG 65280

CTGTCGTACT CGGTGTAGTC GTCGGGAAAC ATGCAGGTCC ACAGCGCGGC CAAAGCGGCG 65340

CTCGGCAGAC ACATGCGCCC GAGGACGCTC ACCGCCGCCA GGGCCTGGGC CGGACTGAGC 65400

TTCCCGAGCG CCGGGGCGTC CCGGCGCTGG GTCCCGAGCT CCAAGGCCGA GCGCCAGGGC 65460

GCCAGCGGGT CGGTTTCGGA CAGCTTGCCC CGGCGCCAGT CGGCCAGCCG CGTGCCGAAC 65520 AGGAGGCCCC GGGTCGGGGG GCCTCCGTCC AAAAACGTCG GCAACACGCG GATGCGGGCG 65580

TCGGGATGCG GGGTCAGGCG CTGGACGAAC AGCATGGACT CCGCTGCGTC CTCGAACGCG 65640

CGTTCGAGGG TGAGGTGCAT GTACTCGTGC TGGCGAACGA GGTCCAGGCG CCAGAAGTTG 65700

TAGATGTGTT CCGGAACGCC GGCCACCAGC GCGACCAGCA CGTCGTTCTC GTTGAAGGCG 65760 ACGCAGTGGC GCTGGGACCC CCGGGGGCCC GGCGGCGGAC GCGGCGCCGC CGCTCCGGAC 65820

GCCCAGCCCA GCTGGGCCCA GCGACACCCA AACTCGCGCG TGAGGGTGGT GGCGACGAGG 65880

GCGACGTACA GCTCGGCCGC CGCGTCGATC GAGGCGCCCC ACGTCGCCTG GCGATGGCGC 65940

ACGAAGCGAC CGAACAGCTG AAAGTTGGCG GCCTGGGCGT CGCTGAGGGC CAGCTGGAGC 66000 CGGTTCACGA CGGTCAGCAC GTACATGGCC GTGACCGTCG GGGCCGATTC GAGGACGTCC 66060

GTCGGAAGCG GGGGCCGCAC GCAGGCCGCC TCGGGACGCA TCAGCAGCGC GCCGAGTTTG 66120

TCGGTGACGG CCGGGAAGCA TAGCGCGTAC TGCAGCGGCG TTCCGTCCGG GGCCAAAAAG 66180

CTGGTGGCGA ACGGCAGATC CAGAGCGCTG ACGGCCTCAC GCAGCACCAG GGGCCCCGGG 66240

TCTCCGCCGG CGCGCAGATA CGCCTCGCCC CGGCGGCGCA GCAGCTGCGG GTCGACCTCG 66300 TGGCCCTCGG GGGAAGAAGA GGCCCGGGCG CGGGCGTCGA GGGCGCGAAG ATCAACGAGC 66360

AGGGGCGCGG GCGCGGCCGC CGCGCCCGCG CCCGTCTGGC CGCCGGCCCT GGCGTACGCG 66420

CTATATAAGC CCATGCGGCG TTGGATGAGT TCCCGCGCGC CCCGGAACTC CTCCACCGCC 66480

CACGGGGCCA GGTCCGCGGC CGCCGCGTCG AACTCCGCCA GCAGGCGCCC CAGGGCGTCA 66540

AAGTTCATCT CCCAGGGCAC CCTGCGCACC ACCTCATCCC GCAGCCGGGC GCACAGGGCG 66600 GTGTGCTTGG TGACGCGCGC GCCCAGCTCC TCCACGGCCT CCGCGCGCTC GGCGCCCTTG 66660

GCGCCCAGGA CGCCCTGGTA CCTGGCGGAA AGGCGCTCGT AGGCCGGCTG GGCCCGCAGC 66720

CCCGACACCG TGTTGGTGGT GTCCTGCAGG GCGCGCAGCT GCTCGTGCAT GGCGCGGAAC 66780

CCCTCGGGGG ACTTCCAGGC GCCCCCCCGG ACGCGGCCAA AGCGACCCCA GACCTCGTCC 66840

CACTCCGCCT CGGCCTCCTC CAGGGACCTC CGCAGGGCGT CGACGCGGCG CCGAGTATCA 66900 AAGAGCGCCC CCAGGCGGCC GGCGTGCCGC GCCAGGGGGC CGGGGCCGTC GCCGCGGGCG 66960

GCGCTTAGCG GGTGCGTCTC GAAGGTGCGC TGGGCGTGCT CTAGCCAGAT AACCGCGGGC 67020

ACGTCGAGCT CGCGCGTTTT CTCGGTCTGA TCCAACAGAA CCTCGACCTG GTCGGCGATC 67080

TCCGCCACCG AGCGCGCCTG GTCGAGCGTC TTGGCCACGG TCGCCGGGAC GGCGACCACC 67140

TTCAGCATGG TCTTGAGGTT GGCCAGGCCC TCGGCCTCGA TCTGGGCCCG GCGCTCGCGC 67200 GCGGCCAGCG CCTCCCGCAG GCCCGCCATG ACCCGCTCGG TGGCCTCCGC GCGCTGCTGT 67260

TTGGCGCGCA CCACTGCGTC CTTGGTCTCG GCCGTGTCCT GCCGGGTCAC GAAGGCGACA 67320

TACTCGGCGT ACGCCGTGTT CTTCACGGGG CTCTGGTCCA CGCGCTCCAA CGCCGCCGCG 67380

CACGCGACCA GCGCGTCCTC GCTGGGACAC GGCAGGGTGA CCCCGGTCCG GACCAGCTCC 67440

GCGGTGGCCT CCGGGTCATT CCGGGCCGCG GATATCTGCT CCGCGGCGGC CGCCAGGTCC 67500 AGGGGCACGC CGCCGAGCGC CCGGTGCACG TCGGCCCGGA TGGCGTCCAG GCGATCGCGG 67560

AGCTCCACGT AGTCGGCGTA GCCATGTTGG AAGAACGGCA CGTACCGGCG CAGGCCGGGC 67620

ACGCTCGTCA TGTCGTCCGC CAGGCGCCCC ACGGCCTCGT GGTAGTCGAT AAACCCGTCG 67680

CCCGCCTGGG CCATTTCCAG GAGCCCCTCC GCGATGCGCA GCAGCCGCGC CAGGGGCTCG 67740

GCGTCGACCC GAAACATGTC GGCGTAGGTT TCGGCGGCGG CGTGGAACGC CGCGCTCCAG 67800 CCGAGGCGGT GGATGGCGGC GAGCGGGGGG AGCATGGGGT GGCGCTGGTT CTCGGGGGTG 67860

TAGGGGTTAA ACGCGAAGGC CGTATCCAGG GCGAGGGTGA CCGCCTCGGC GTTGGCCGCG 67920

AGCGCCTGCT CGGCGCGCTT GCGGAAGTCC CGGGGGTTGT AGCCGTGCGT GCCCGCCAGC 67980

GCCTGCAGGC GGCGCAGCTC GACCACGTCG AACTCGGCGC GGTTCTCGAC GCGGTCCAGC 68040

GCCGCCTCGA CGCCGGCGGC CCAGCGCTCG CTGCTGCCCC GGGCGCGCTG GGCCGCCATC 68100 TTCGCCGTCA GGTCGGCGAC GGCGGCCTCA AGTTCGTCGG CGCGGCGTCG CGTGGCGCCG 68160

ATGACCTTGC CCAGCTCCTG CAGGGCGCGC CCGCTGGGGG AATGGTCCCC GGCCGTCCCT 68220

TCGGCGTGCA GCAGGCCCCC GAACCCAGCC TCGTGCCCCG CGAGGCTTTC CCGAGCAGCG 68280

GTCGTCGCGC GGGCCGCGGC ATCGATGAGG GCGGCATGGT CCCCCTCCGG CTGGGCGCAG 68340 GCCCGGCGCG CCTGGACTAC CAGGTCGGCG GCCGCCGACC CCAGGGTCGT GAGCTCGTCG 68400

ATGGCCCCCC GCGCCTCCAG GGCCAGCCGA GTCGCCTTTA CATACCCCGC GGCGCTATCG 68460

GCCAGCGCCG CGAGGAAGGA CAGGGGGGAG GCCGGGTCGC GGGCGGCCGC GCCCAGGGCC 68520

GACACCGCGT CCGCCAGGGC GCCATGCGCC CGCACGGCCG CGTCCACCGT CGCCGCGGGA 68580 CTTGCCGTCG CGACGGCGGC GCTCCCGGCG TTGATGGCGT TTGACACGGC TTTGGCGATT 68640

GTGGGGGCGT GATCGGAAAA GAACTGCACG AGGACCGGCG TCTCGGGGGC GTCGGCGAAC 68700

AGGGTCTTCA GCACCACCAC GAAGGCGGGA TGCAGGCCGG CCAGAGCCGT CGCGGTATCC 68760

GGGGTCGGGT GTTCCAGGGC CTCCCGGTAC TGCCCCAGCA GCCCCCACAG GTCCGCCCGC 68820

AGCGCCGCCG TGACTTCCGG GGGGGGGCCC CGGACGGCAT CGGCCAGGTC GGTCCACCCC 68880 GCGGGCAGGG AGGCCCGCAG GGTCGCCAGC ACGGCCGGAC ACGCCTTTAG CCCCACAAAG 68940

TCCGGGAGGG GCCGCAGGAC CCCTTGGAGT TTGTGCAGGA ACTTCTCCCG GGCGTCGTGG 69000

GCCACCTTGG CGCGCTCCCG CGCGTCGTTG AGCATCGCCT CCAGGGCGTG GGCGCGCTCC 69060

CGAAGCCGGG AGCGCGCCTC CGGAGCGAGC TCCGCCGTCA TCTTGGCCGC CTCCATGGCC 69120

CTCGCCTGCC GCAGCGCGTC TTCGGCCATG CGCGTGGCCT CGGGGGACAG CCCGCCCCCG 69180 TCGACGTACG GCGCGGGGCC GGTCGCCGGG ACGAAGGCCG CGTCGCTGTC CAGCTGCTGC 69240

GCGAGCGCCG CGTCGAGGGC GTCGAAGCGC TGCAGTTCGG CCAGCCCCGA GCTGCGCCGC 69300

GCCTGCTGGT CGTTGATGCC GTGGATGCTG CGCGCCAGCT CTTCCAGGGG CTTGCGTTCG 69360

ATGAGCCCCT GGGTCGCGGC GTCGGTCAGG ACCGAGAGCC AGGCCGCCAG GTCCTCGGGG 69420

GCATCTAGGG TCTGGCCCCG CTGGAGCAGG TCCCGCAGCA GGATGGCCTG GGGGCTGGTG 69480 GCGAGGGGGG GCGGGGGGGG GAGCGCGGCG CGCTGAGCGA CGTCCCGCGT GTGTTGGTCA 69540

AAGGCCGGTA GCGATTCCAG CAACTGGACC ATGGGCACGA CCGCGGCCGA GGCCACGTGA 69600

AACCGACAGT CGTGGCTGTC GCTGGCCTGC AGGGCCTTCG CGCTGTATAC GGCTCCCCGG 69660

TGGAAGTACT CCTTGATCGC GCTCTCGATC GCCCGGCGGG CCTGGATCCG CACGTCCTCC 69720

AGCCGCGCCT GGATGGCCTC GGGGCCCAGG GCGGGCGGGC ACGGGGCCCT GCCGCCGGCG 69780 CCCGGGGCGG CGGGCACGGG CATCACGGTC AGGGGCCCGG CGCGCTGCGA GACCGAGTCG 69840

ACCCCGCGGG CGAGGGCGTC TAAGGCCTCG CGCATCTCGC GGGCCTCCGC CTCGACCCGC 69900

ATCTCTTCGC CCCGGGCAAA CTGGGCCAGC GCCTGGATCC GATGGAGAAG CGGCTCCGGG 69960

TGCGTCGGGG TGGCGGGGGC GAACAGGGTG TTCGGGTGGG CGCGCGAGCG CTCCAGGAGC 70020

CACTCTCCGA GGCGTGCGTA CAGATTGGCC GGCGGGGCGG CGCGCAGCTG CAGATCCAGG 70080 TCCGCGAGGT CCCCGTAAAA GGCGTCCGTC TCCCGAATAA CGTCCCTGGC GACCAGGACC 70140

AGCTTAGCGA GGGCCAGGCG CCCGATCTGC GAATTTTCGT CCAGCACGTG CTGGATGAGG 70200

GGCCGGTGGG CGGCCACGTC CGCCAGGCTC ATGCGCGTGG ACGCCAGGAA GTCCCCGACG 70260

GCCGTTTTGC GGGGCAGCAT GCGCAGGGTG AAGTCCAGCA GGGCCGCGGC CGGGCCGGCC 70320

ACCCCGGCCT GCGTATGCGT GCGGGCCCCG TTCTCGATCA AAAAGGCGAG GACGCGCTCA 70380 AAGAAGAAGA TGACGCAGAG CTCCAACAGC CCCGGGTGCG CCGGGTACGG CGACCGCAGG 70440

GCGTTGATGG TGAGCTGCGA ACACGCGGCC ACCTCGCGGG CCAGGGCGGC ATCGCGCGCC 70500

GCGAGCCGGA CCGCCGTGGC GGCCACATTG GGGTGGACCT CGAACAGCTG CGCCAGGTCG 70560

GCGCCGGGGG GCTCCGGGGG GCGGCGGGCC CCCAGCGTCT CGAGCACGGA CGGCGACGAC 70620

GGGCTCGCGG GCCCGTCATC GCCGCCTCCC TGCCCGGACT GCGGGGGGGT ATCCGGTGCG 70680 GGAGGGACCG TGGCGGCTAT GGGCGTCGGG GAGGAGGCGG GGACCTCGGC GGCGACGGGG 70740

GCCTTCTTCT TGGGCGCGGA CTTCTTCTTG GCCTTGGCGG GCGGGGCCTT GGGGGCGGGC 70800

CTCTCGCCCG AGGTCAGATC CTCCACGCTG GACGGTGGGG TCCAGGTGGG CCGGCGGCGC 70860

TTGGGCAAGC CGGTAGAATA GCGCGCCCGG TGGCGACCCA CCGGCACTGC CCCCACCTCC 70920 AGGACCCGCA GGTCCTCGGC TTCTTCGGCC GCGTCCCCGG CGGGTGTCTG CGGGGGCGGG 70980

GCGGCGTGCG GTGGACCCGA GGCCGCGGCG TCCGGGGCCG AGGGCTTTGC GGGCGGGGTC 71040

CCCTCCAGGG CTGCTGCCCA CACATCATCG GGGGGGCGGT TTGGGTGCCC CGCCTGCGGT 71100

GTGTTGGGTG GGCCCGAGGC CCCCCGGGGG GCCTCGGGGG GCCGGTCGGC CCGAGGGGTC 71160 TGGACGTGGG TGGGCGCGGG GAGCGCGGGG ACGACCGGGC CCGAGCCTTC TCCGTCCCCC 71220

CTGGGGACCA CACCGACAAA GAGCGCCCCT AGCCCCCCGA TCTCGCCCCG CAGGGGGTGG 71280

GTGATGGCCA CGCGCCGCTC GACGAACGGT TCGTCCTGCA GGTAAGTCTC GCTGGCCCCG 71340

TAGAGGTGCA GGGCCGCGGC GGTCAGGTCC GCCGGCGCCA CGGCCCCCGG GCCGGAGGGC 71400

ACAAAAAACA CCATGGCGCC CGCCCACCGC ACCTTGGGGC GGTCGTGGGC GTAATACGTC 71460 AGGTACGGGT ACACGTCGCC CGCCCGCACC TTGGCGATAA ACGCGGGCGT TCCCGCGGGC 71520

AGGCCGTGCG GGTCAAACAG ATAGGCCGTG TCGCCGTCCC GGTAGAGCCC CATGCCCAGG 71580

GGGCCGATGG TCAGGAGCGT GTAGGACAGC GGCCGCATGG CCCAGGGGCC GGCGAAGAAC 71640

GTGTGCGCGG GGCATTGCGT CTCCAGCAGC CCCGCCGTGG GCTCCCCGAA GAAGCCCACC 71700

TCGCCGTACA CCCGCGAAAA CACGCAACGC AGGCCGCCGC GCGCCGCCGG GTACTCCAGG 71760 AAGTTGGGGA GCTCGATAAT GGAACACATG CGCGGCGGCC CGGAGCCCGC GGCCGCGCGC 71820

GTCCACTCGC CCCCCTCCAC CAGACATCCC TCAATGGCCT CCGCGGACAG CACGTCGCGG 71880

GGCCCCACGT CGAAAAGAAG ACTGAGAAAC GACAGGGACG AGCGCATGCA CGATACCGAC 71940

CCCCCCGGCT CCAGATCGGT CGCGAACTGG TTCCGAACAC CGGTGACCAC GATATCGCGA 72000

TCCCCCTGGC GCTTCATCGT GGGGTGAGGT AGCGCGGCCG GAATCATGTG TGCCGCGCCC 72060 GCCACGAGCG GGGCCTGTTT ATGGGCCGGG CGTCCCGATG AGTACTGTTG TTTCCGCCGC 72120

CCGAACCCCC CCCGCCCATC AACCGCCTGT TCGTCCCCCT AACCACACAC CCGGTATCGC 72180

GTGTGTGGTT TCCCGGGAAG CCACATCCCA CCCCATGAAG TTTTGCCCTT TTTTTCCGTC 72240

CCGCACTACG CCACCTTTCC ACCCCCCCCC CCCAAAAAAA AAAAAACAAC AACCAACTCC 72300

CAGATGGATG GGTGCGATAA TAAAGCTTTA TTATTGTTTA ACCAAAGGCG AGTCCTACGG 72360 GTGTACCGGT GGTGTCTCCT GCGGCGTCAT CTCGTCGTCC TCCACGGGGG TGTTGGGCCA 72420

AGGGACCGTC TCGCGGCCCG CCGGGCGCGT CGACGGCGCG CGGGCCTGCG TGTCCTGTGG 72480

GCCGGGTGTC GTGGGTTCGG GGGTGCTACC GCCGGCATCT TGGGCCTCCA GGTCCCCGGG 72540

GGCCTCCGGG CCGGCGGAAG GCCGAAACGC CGAGGCGCGA AACACGCCGT CGGTGACCTG 72600

CAGGAGCTCG TTTATTAATA GCCAGTCCAT GCTCAGCGTA GCGGCCAGCC CCTGGGGAGA 72660 CAGGTCCACG GAGTCCGGAA CCACCGTCGG CTGACCCAGG GGCCCCAGGC TGTAGTCCCC 72720

CCAGGCCCCC AGGTCATGAC GGTTCGTGAG CACGACGAGG TCTGCGGCCG GGCTGGGGGG 72780

CGCGTCCTCG GTCGCGTGGG CCATCACCTC CTGAATGGCT GCGGTGCGCT GATCGGCCGA 72840

GCTGGCGAAG GGCGCCACGA CCAGCGCGCG CTCCGTCTGC AGGCCCTTCC ACGTGTCGTG 72900

GAGTTCCTGA ACGAACTCGG CCACCCGCTC GGGGCCCGTG GCCGCGCGCG CGGCCTGATA 72960 GCCGGCCGAG AGGCGCCGCC AGCGCGCCAG GAACTGACTC ATGTAACAGA ACCCGGGGAC 73020

CTGGTCCCCC GACATCAACT TTGACGCCCT GGCGTGGATG CCCGACACGA TGGCCAGGAA 73080

CCCGTGGATT TCCCGCCGCA CGACGGCCAG CACGTTACCC TCGTGCGAGA CCTGGGCCGC 73140

CAGCTCGTCG CATACCCCGA GGTGCGCCGT CGTCTCGGTG ACGACGGACC GCAGCCCCGC 73200

GAGGGACGCG ACCAGCGCGC GCTTGGCGTC GTGATACATG CCGCAGTACT GGCTCACCGC 73260 GTCGCCCATG GCCTCGGGGC GCCAGGGCCC CAGGCGCTCG TGGGCGTCTG CGACCACGGC 73320

GTACAGGCGG TGCCCGTCGC TCTCGAACCG GCACTCAAAG AAGGCGGCGA GCGTGCGCAT 73380

GTGCAGCCGC AGCAGCACGA TCGCGTCCTC CAGCTGGCGG ACCAGGGGGT CGGCGCGCTC 73440

GGCGAGCTCC TGCAGCACCC CCCGGGCCGC CAGGGCGTAC ATGCTGATCA GCAGCAGGCT 73500 GCTGCCCACC TCGGGAGGCT GGGGGGGAGG CAGCTGGACC GCGGGCCGCA GCTGCTCGAC 73560

GGCCCCCCTG GCGATCACGT ACAGCTCGCG CAGCAGCTGC TCGATGTTGT CGGCCATCTG 73620

CATCGTGGGC CCGACGCCGG CCCGGGTGGC CGGTTCGAGG AGGGTGATCA GCGCGCCCAA 73680

TTTTGTGCGG TGCCCCTCGA CGGTGGGGAG ATAGCCCAGG CCGAAGTCGC GCGCCCAGGC 73740 CAGCACCCGC AGGGCAAACT CGATGGGGCG GGGCAGGTAG GCAGCGTTGC ACGTGGCCCT 73800

CAGCGCGTCC CCGACCACCA GGGCCAGCAC GTAAGGGACG AACCCCGGGT CGGCGAGGAC 73860

GTTGGGGTGG ATGCCCTCCA GGGCCGGGAA GCGGATCTTG GTGGCCGCGG CCAGGTGAAC 73920

CGAGGGGGCG TGGCTAGGCG GCCCGACGGG GAGCAGCGCG GACAGCGGCG TGGCCGGGGT 73980

GGTGGGGGTC AGGTCCCAGT GGGTCTGGCC GTACACGTCG AGCCAGATGA GCGCCGTCTC 74040 GCGCAGGAGG CTGGGCTGGC CGGCGCTGAA GCGGCGCTCG GCCGTCTCAA ACTCCCCCAC 74100

GAGCGTGCGC CGCAGGCTCG CCAGGTGTTC CGTCGGCACG GCCGGGCCCA TGATGCGCGC 74160

CAGCGTCTGG CTGAGGACGC CGCCCGACAG GCCGACCGCC TCACAGAGCC GCCCGTGCGT 74220

GTGCTCGCTG GCGCCCTGGA TCCGCCGGAA CGTTTTCACG TAGCCGGCGT AGTGCCCGTA 74280

CTCCCGCGCG AGCCCGAACA CGTTCGCCCC CGCAAGGGCA ATGCACCCAA AGAGCTGCTG 74340 GATCTCGCTG AGCCCGTGGC CGGGGGGCGT CCGCGCGGGC ACCCCCGCCA CCAAAAACCC 74400

CTCCAGGGCC GATATGTACT GGGTGCAGTG CGCGGGCGTG AACCCCGCGT CGGTAAGCGT 74460

GTTGATCACC ACGGAGGGCG AGTTGCTGTT CTGGACCAAA GCCCACGTCT GCTGCAGCAG 74520

CGCGAGGAGC CGTTGCTGGG CCCCGGCGGA GGGCGGCTCC CCTAGCTGCA GCAGGCCGGT 74580

GACGGCCGGA CGGAAGATGG CCAGCGCCGA CGCACTCAGA AACGGCACGT CGGGGTCGAA 74640 GACGGCCGCG TCCGTCCGCA CGCGCGCCAT CAGCGTCCCC GGGGGCGCGC ACGCCGACCG 74700

CGGGCTGACG CGGCTTAGGG CGGTCGACAC GCGCACCTCC TCGCGACTGC GAACCATTTT 74760

GGTGGCCTCG AGGGGCGGGA TCATGATAGC CGGGTCGATC TCCCGCACCG TGTGCTGAAA 74820

CTGGGCCAGC AGCGGCGGCG GGACCACCGC GCCCCGATCG GGGGTCGTCA GGTACTCGTC 74880

CACCAGCGCC AGCGTAAACA GGGCCCGCGT GAGGGGGGTC AGGGCGGCGT CGTCGATGCG 74940 CTGTAGGTGC GCCGAGAACA GCGTCACCCA ATTGCTGACC AGGGCCAAGA ACCGGAGACC 75000

CTCTTGCACG ATCGGGGACG GGAAGAGCAG GCTGTACGCC GGGGTGGTCA GGTTGGCGCC 75060

GGGTTGCCCC AGGGGAACCG GGGACATCTT AAGCGACATC TCCCCGAGGG CCTCCAGGGA 75120

GGTCCGCGGG TTCATGGCCA GGCAGCTCTG GGTGACGGTC CGCCAGCGGT CGATCCACTC 75180

CACGGCACAC TGGCGGACGC GCACCGGCCC CAGGGCCGCC GTGGTGCGCA GCCCGGCGGC 75240 CTCCAGCGCG TGGGTCGTGT CGGAGCCGGT GATCGCCAGG ACCGTGTCCT TGATGACGTC 75300

CATCTCCCGG AAGGCCGCCT CGGGGGTCTC GGGGAGCGCC ACCGCCATGC GGTGCACCAG 75360

CAGCCCGGGG AGGTTCTCGG CCAAGAGCGC CGTCTCCGGA AGCCCGTGGG CCCGGTGCAA 75420

GGCGCACAGT TGCTCCAGGA GCGGGTGCCA GCACGCCCGC GCCTCCGCCG GGCCGACCGC 75480

CGCGCCCGAC AACAGAAACG CCGCCGTGGC GGCGCGCAGT TTGGCCGCGG ACAGAAACGC 75540 CGGCTCGTCC GCGCTGCCCG CCGGCTCGCT CGAGGGGGAG GGCGGCCGGC GGAGGTTGGT 75600

CAGGCTCCCC AACAGGACCT GCAACGGTCC GTTTGGGGGT GGAGCGGACG GGGGGGTCAT 75660

GCCGGCGGGC GCCGGGACCT GGAGCGCGCT GTCCGACATG GCGACCGGCG TGCGCGCTCG 75720

GCGACGCGGC GCGGAGACCG CGGGCCCAAA CGGGAATGAC TGCCGCCGCC CTATACGGAG 75780

GGGCTAAGTA TCGCCCGGGG ACCCTTCGAA ACCCCGGGCG TGTCGCAAGT ACGCCGCGAA 75840 GGCGCGGCGT GTTATACGGC GCGTTATGTC CCGGCATTCC GTTCGTGGGT TCGGGCCCGG 75900

GTGCTGTCGG GTGGGAGTGT GTGTGTGTGG GGGGGGGGCG GCGCGACGGC GGCCCGGACC 75960

AAGTGTATCG CGGCCGTTCC GTGGGGCGGC CCAACAGGCC CTTTAAACAT TTGCGTATGC 76020

ACCGGCCCAG CCAGTCGGAC ACCGGAACCC ACCAGAGGCG GAAGCCGCCT TCGCCCGTGA 76080 GGGTGCGTGT GTTTTCTGGT GGCGTGTTTT TCCTTTCCGC CCTCCTCCCT CCCCACCTCC 76140

ACCACCCCCC CCCCACAACT CGCCCGTTGG CGATCGGCGG GAAAACCATG AAAACCAAGC 76200

CACTCCCGAC AGCCCCGATG GCGTGGGCCG AGAGTGCCGT GGAAACCACC ACCAGCCCGC 76260

GCGAGCTCGC GGGCCACGCC CCGCTCCGGC GCGTCCTGCG CCCGCCCATC GCTCGCCGCG 76320 ACGGCCCGGT GCTTTTGGGG GACAGGGCCC CCAGGAGGAC GGCCAGTACG ATGTGGCTGC 76380

TGGGGATCGA CCCCGCGGAG TCGTCTCCGG GAACGCGCGC TACCCGAGAC GATACCGAGC 76440

AGGCCGTGGA CAAGATCCTC AGGGGAGCCC GGCGCGCGGG AGGGCTGACC GTCCCCGGCG 76500

CCCCCCGCTA TCACCTGACC CGCCAGGTAA CCCTGACGGA TCTCTGCCAA CCAAACGCGG 76560

AGCGGGCCGG GGCGCTCCTT TTGGCCCTGC GGCACCCCAC CGACCTCCCC CACCTGGCCC 76620 GCCATCGGGC TCCGCCCGGC CGGCAGACCG AGCGACTGGC CGAGGCCTGG GGCCAGCTCC 76680

TGGAGGCCTC CGCCCTGGGG TCCGGGCGGG CCGAGAGCGG CTGCGCGCGC GCGGGCCTTG 76740

TGTCGTTTAA CTTTCTGGTG GCCGCGTGCG CCGCCGCCTA CGATGCGCGC GACGCCGCCG 76800

AGGCGGTCCG GGCCCACATC ACGACCAACT ACGGCGGGAC GCGGGCCGGG GCGCGGCTGG 76860

ACCGGTTTTC CGAATGCCTG CGCGCCATGG TCCACACGCA CGTGTTTCCC CACGAGGTCA 76920 TGCGGTTTTT CGGGGGGCTA GTGTCGTGGG TCACACAGGA CGAGCTGGCT AGCGTCACCG 76980

CCGTCTGCAG CGGACCCCAG GAGGCCACAC ACACCGGCCA CCCGGGCAGG CCCTGTTCGG 77040

CCGTTACCAT CCCGGCCTGC GCCTTCGTGG ACCTGGACGC CGAGCTGTGC CTGGGGGGCC 77100

CTGGGGCGGC GTTCCTGTAC TTGGTCTTCA CCTACCGACA GTGCCGGGAC CAGGAGCTCT 77160

GTTGCGTGTA CGTGGTCAAG AGCCAGCTCC CCCCGCGCGG ACTGGAGGCG GCCCTCGAGC 77220 GGCTGTTCGG GCGCCTCCGG ATAACCAACA CGATTCACGG GGCCGAGGAC ATGACGCCCC 77280

CTCCCCCGAA CCGAAACGTT GACTTTCCGC TCGCCGTCCT GGCCGCGAGC TCGCAATCCC 77340

CGCGGTGCTC GGCGAGCCAA GTCACGAACC CCCAGTTTGT CGACAGGCTG TACCGCTGGC 77400

AGCCGGATCT GCGGGGGCGC CCTACCGCAC GCACCTGCAC ATACGCCGCC TTCGCAGAGC 77460

TGGGTGTCAT GCCAGACAAC AGCCCCCGCT GTCTGCACCG CACCGAGCGG TTTGGGGCGG 77520 TCGGCGTTCC GGTTGTCATC CTGGAGGGCG TGGTGTGGCG CCCCGGCGGG TGGCGGGCCT 77580

GCGCGTGATC GTCTATTGAC GACGGCCGCC CAACCCGAGC GACCTTCCCC TCCCACTTTC 77640

CCCCCCCCCC CTCCTACACA CCAACTCCGC CCTCGCCGTC TTGGCCGTGC GCGGCCCCGT 77700

GCGTCCGTCT CAATAAAGCC AGGTTAAATC CGTGACGTGG TGTGTTTGGC GTGTGTCTCT 77760

GAAATGGCGG AAACCGACAT GCAAATGGGA TTCATGGACA CGTTACACCC CCCTGACTCA 77820 GGAGATAGGC ATATCCTCCT TAGATTGACT CAGCACACGA TCGCACCCCA CCCCTGTGTG 77880

CCGGGGATAA AAGCCAACGC GGGCGGTCTG GGTTACCACA ACAGGTGGGT GCTTCGGGGA 77940

CTTGACGGTC GCCACTCTCC TGCGAGCCCT CACGTCTTCG CCCACCGATT CCTGTTGCGT 78000

TCCTGTCGGC CGGTGCTGTC CTGTCGACAG ATTGTTGGCG ACTGCCCGGG TGATTCGTCG 78060

GCCGGTGCGT CCTTTCGGTC GTACCGCCCA CCCCGCCTCC CACGGGCCCG CCGCTGTTTC 78120 CGTTCATCGC GTCCGAGCCA CCGTCACCTT GGTTCCAATG GCCAACCGCC CTGCCGCATC 78180

CGCCCTCGCC GGAGCGCGGT CTCCGTCCGA ACGACAGGAA CCCCGGGAGC CCGAGGTCGC 78240

CCCCCCTGGC GGCGACCACG TGTTTTGCAG GAAAGTCAGC GGCGTGATGG TGCTTTCCAG 78300

CGATCCCCCC GGCCCCGCGG CCTACCGCAT TAGCGACAGC AGCTTTGTTC AATGCGGCTC 78360

CAACTGCAGT ATGATAATCG ACGGAGACGT GGCGCGCGGT CATTTGCGTG ACCTCGAGGG 78420 CGCTACGTCC ACCGGCGCCT TCGTCGCGAT CTCAAACGTC GCAGCCGGCG GGGATGGCCG 78480

AACCGCCGTC GTGGCGCTCG GCGGAACCTC GGGCCCGTCC GCGACTACAT CCGTGGGGAC 78540

CCAGACGTCC GGGGAGTTCC TCCACGGGAA CCCAAGGACC CCCGAACCCC AAGGACCCCA 78600

GGCTGTCCCC CCGCCCCCTC CTCCCCCCTT TCCATGGGGC CACGAGTGCT GCGCCCGTCG 78660 CGATGCCAGG GGCGGCGCCG AGAAGGACGT CGGGGCCGCG GAGTCATGGT CAGACGGCCC 78720

GTCGTCCGAC TCCGAAACGG AGGACTCGGA CTCCTCGGAC GAGGATACGG GCTCGGGTTC 78780

GGAGACGCTG TCTCGATCCT CTTCGATCTG GGCCGCAGGG GCGACTGACG ACGATGACAG 78840

CGACTCCGAC TCGCGGTCGG ACGACTCCGT GCAGCCCGAC GTTGTCGTTC GTCGCAGATG 78900 GAGCGACGGC CCTGCCCCCG TGGCCTTTCC CAAGCCCCGG CGCCCCGGCG ACTCCCCCGG 78960

AAACCCCGGC CTGGGCGCCG GCACCGGGCC GGGCTCCGCG ACGGACCCGC GCGCGTCGGC 79020

CGACTCCGAT TCCGCGGCCC ACGCCGCCGC ACCCCAGGCG GACGTGGCGC CGGTTCTGGA 79080

CAGCCAGCCC ACTGTGGGAA CGGACCCCGG CTACCCAGTC CCCCTAGAAC TCACGCCCGA 79140

GAACGCGGAG GCGGTGGCGC GGTTTCTGGG GGACGCCGTC GACCGCGAGC CCGCGCTCAT 79200 GCTGGAGTAC TTCTGTCGGT GCGCCCGCGA GGAGAGCAAG CGCGTGCCCC CACGAACCTT 79260

CGGCAGCGCC CCCCGCCTCA CGGAGGACGA CTTTGGGCTC CTGAACTACG CGCTCGCTGA 79320

GATGCGACGC CTGTGCCTGG ACCTTCCCCC GGTCCCCCCC AACGCATACA CGCCCTATCA 79380

TCTGAGGGAG TATGCGACGC GGCTGGTTAA CGGGTTCAAA CCCCTGGTGC GGCGGTCCGC 79440

CCGCCTGTAT CGCATCCTGG GGATTCTGGT TCACCTGCGC ATCCGTACCC GGGAGGCCTC 79500 CTTTGAGGAA TGGATGCGCT CCAAGGAGGT GGACCTGGAC TTCGGGCTGA CGGAAAGGCT 79560

TCGCGAACAC GAGGCCCAGC TAATGATCCT GGCCCAGGCC CTGAACCCCT ACGACTGTCT 79620

GATCCACAGC ACCCCGAACA CGCTCGTCGA GCGGGGGCTG CAGTCGGCGC TGAAGTACGA 79680

AGAGTTTTAC CTCAAGCGCT TCGGCGGGCA CTACATGGAG TCCGTCTTCC AGATGTACAC 79740

CCGCATCGCC GGGTTCCTGG CGTGCCGGGC GACCCGCGGC ATGCGCCACA TCGCCCTGGG 79800 GCGACAGGGG TCGTGGTGGG AAATGTTCAA GTTCTTTTTC CACCGCCTCT ACGACCACCA 79860

GATCGTGCCG TCCACCCCCG CCATGCTGAA CCTCGGAACC CGCAACTACT ACACGTCCAG 79920

CTGCTACCTG GTAAACCCCC AGGCCACCAC TAACCAGGCC ACCCTCCGGG CCATCACCGG 79980

CAACGTGAGC GCCATCCTCG CCCGCAACGG GGGCATCGGG CTGTGCATGC AGGCGTTCAA 80040

CGACGCCAGC CCCGGCACCG CCAGCATCAT GCCGGCCCTG AAGGTCCTGG ACTCCCTGGT 80100 GGCGGCGCAC AACAAACAGA GCACGCGCCC CACCGGGGCG TGCGTGTACC TGGAACCCTG 80160

GCACAGCGAC GTTCGGGCCG TGCTCAGAAT GAAGGGCGTC CTCGCCGGCG AGGAGGCCCA 80220

GCGCTGCGAC AACATCTTCA GCGCCCTCTG GATGCCGGAC CTGTTCTTCA AGCGCCTGAT 80280

CCGCCACCTC GACGGCGAGA AAAACGTCAC CTGGTCCCTG TTCGACCGGG ACACCAGCAT 80340

GTCGCTCGCC GACTTTCACG GCGAGGAGTT CGAGAAGCTG TACGAGCACC TCGAGGCCAT 80400 GGGGTTCGGC GAAACGATCC CCATCCAGGA CCTGGCGTAC GCCATCGTGC GCAGCGCGGC 80460

CACCACCGGA AGCCCCTTCA TCATGTTTAA GGACGCGGTA AACCGCCACT ACATCTACGA 80520

CACGCAAGGG GCGGCCATTG CCGGCTCCAA CCTCTGCACG GAGATCGTCC ACCCGTCCTC 80580

CAAACGCTCC AGCGGGGTCT GCAACCTGGG CAGCGTGAAT CTGGCCCGAT GCGTCTCCCG 80640

GCGGACGTTC GATTTTGGCA TGCTCCGCGA CGCCGTGCAG GCGTGCGTGC TAATGGTTAA 80700 TATCATGATA GACAGCACGC TGCAGCCGAC GCCCCAGTGC GCCCGCGGCC ACGACAACCT 80760

GCGGTCCATG GGCATTGGCA TGCAGGGCCT GCACACGGCG TGCCTGAAGA TGGGCCTGGA 80820

TCTGGAGTCG GCCGAGTTCC GGGACCTGAA CACACACATC GCCGAGGTGA TGCTGCTCGC 80880

GGCCATGAAG ACCAGTAACG CGCTGTGCGT TCGCGGGGCG CGTCCCTTCA GCCACTTTAA 80940

GCGCAGCATG TACCGGGCCG GCCGCTTTCA CTGGGAGCGC TTTTCGAACG CCAGCCCGCG 81000 GTACGAGGGC GAGTGGGAGA TGCTACGCCA GAGCATGATG AAACACGGCC TGCGCAACAG 81060

CCAGTTCATC GCGCTCATGC CCACCGCCGC CTCGGCCCAG ATCTCGGACG TCAGCGAGGG 81120

CTTTGCCCCC CTGTTCACCA ACCTGTTCAG CAAGGTGACC AGGGACGGCG AGACGCTGCG 81180

CCCCAACACG CTCTTGCTGA AGGAACTCGA GCGCACGTTC GGCGGGAAGC GGCTCCTGGA 81240 CGCGATGGAC GGGCTCGAGG CCAAGCAGTG GTCTGTGGCC CAGGCCCTGC CTTGCCTGGA 81300

CCCCGCCCAC CCCCTCCGGC GGTTCAAGAC GGCCTTCGAC TACGACCAGG AACTGCTGAT 81360

CGACCTGTGT GCAGACCGCG CCCCCTATGT TGATCACAGC CAATCCATGA CTCTGTATGT 81420

CACAGAGAAG GCGGACGGGA CGCTCCCCGC CTCCACCCTG GTCCGCCTTC TCGTCCACGC 81480 ATATAAGCGC GGCCTGAAGA CGGGGATGTA CTACTGCAAG GTTCGCAAGG CGACCAACAG 81540

CGGGGTGTTC GCCGGCGACG ACAACATCGT CTGCACAAGC TGCGCGCTGT AAGCAACAGC 81600

GCTCCGATCG GGGTCAGGCG TCGCTCTCGG TCCCGCATAT CGCCATGGAT CCCGCCGTCT 81660

CCCCCGCGAG CACCGACCCC CTAGATACCC ACGCGTCGGG GGCCGGGGCG GCCCCGATTC 81720

CGGTGTGCCC CACCCCCGAG CGGTACTTCT ACACCTCCCA GTGCCCCGAC ATCAACCACC 81780 TTCGCTCCCT CAGCATCCTG AACCGCTGGC TGGAGACCGA GCTCGTGTTC GTGGGGGACG 81840

AGGAGGACGT CTCCAAGCTC TCCGAGGGCG AGCTCGGCTT CTACCGCTTT CTGTTTGCCT 81900

TCCTGTCGGC CGCGGACGAC CTGGTGACGG AAAACCTGGG CGGCCTCTCC GGCCTCTTCG 81960

AACAGAAGGA CATTCTTCAC TACTACGTGG AGCAGGAATG CATCGAGGTC GTCCACTCGC 82020

GCGTCTACAA CATCATCCAG CTGGTGCTCT TTCACAACAA CGACCAGGCG CGCCGCGCCT 82080 ATGTGGCCCG CACCATCAAC CACCCGGCCA TTCGCGTCAA GGTGGACTGG CTGGAGGCGC 82140

GGGTGCGGGA ATGCGACTCG ATCCCGGAGA AGTTCATCCT CATGATCCTC ATCGAGGGCG 82200

TCTTTTTTGC CGCCTCGTTC GCCGCCATCG CGTACCTGCG CACCAACAAC CTCCTGCGGG 82260

TCACCTGCCA GTCGAACGAC CTCATCAGCC GCGACGAGGC CGTGCATACG ACAGCCTCGT 82320

GCTACATCTA CAACAACTAC CTCGGGGGCC ACGCCAAGCC CGAGGCGGCG CGCGTGTACC 82380 GGCTGTTTCG GGAGGCGGTG GATATCGAGA TCGGGTTCAT CCGATCCCAG GCCCCGACGG 82440

ACAGCTCTAT CCTGAGTCCG GGGGCCCTGG CGGCCATCGA GAACTACGTG CGATTCAGCG 82500

CGGATCGCCT GCTGGGCCTG ATCCATATGC AGCCCCTGTA TTCCGCCCCC GCCCCCGACG 82560

CCAGCTTTCC CCTCAGCCTC ATGTCCACCG ACAAACACAC CAACTTCTTC GAGTGCCGCA 82620

GCACCTCGTA CGCCGGGGCC GTCGTCAACG ATCTGTGAGG GTCTGGGCGC CCTTGTAGCG 82680 ATGTCTAACC GAAATAAAGG GGTCGAAACG GACTGTTGGG TCTCCGGTGT GATTATTACG 82740

CAGGGGAGGG GGGTGGCGGC TGGGGAAAGG GAAGGAACGC CCGAAACCAG AGAAAAGGAC 82800

CAAAAGGGAA ACGCGTCCAA CCGATAAATC AAGCGCCGAC CAGAACCCCG AGATGCATAA 82860

TAACAAACGA TTTTATTACT CTTATTATTA ACAGGTCGGG CATCGGGAGG GGATGGGGGC 82920

GCGCGTTTCC TCCGTTCCGG CTACTCGTCC CAGAATTTAG CCAGGACGTC CTTGTAAAAC 82980 GCGGGCGGGG GCGCGTGGGC CCACAGCTGC GCCAGAAACC GGTCGGCGAT GTCCGGGGCG 83040

GTGATATGCC GAGTCACGAT GGAGCGCGCT AAATCTTCGT CGCGGAGGTC CTGATAGATG 83100

GGCAGTCTTT TTAGAAGAGT CCAGGGTCCC CGCTCCTTGG GGCTGATAAG CGATATGACG 83160

TACTTGACGT ATCTGTGCTC CACCAGCTCG GCGATGGTCA TCGGATCGGG CAGCCAGTCC 83220

AGGGCCTCCG GGGCGTCGTG GATGACGTGG CGGCGACGTC CGGCGACATA GCCGCGGTGT 83280 TCCGCGACCC GCTGCGCGTT GGGGACCTGC ACGAGCTCGG GCGGGGTGAG TATCTCCGAG 83340

GAGGACGACC GGGCGCCGTC GCGCGGCCCA CCGGCGACGT CCGGGGGCTG GAGGGGGGGG 83400

TCTTCTTCGT AGTCGTCCTC GCCCGCGATC TGTTGGGCCA GAATTTCGGT CCACGAGATG 83460

CGCGTCTCGA GGCCGACCGG GGCCGCGGTC AGCGTAGGCA TGCTCTCCAG GGAGCGCGAG 83520

TTGGCGCGCT CCCGCCGGGC CGCCCGGCGG GCCTGGGATC GGCTCGGGGC GGTCCAGTGA 83580 CACTCGCGCA GCACGTCCTC GACGGACGCG TAGGTGTTAT TGGGGTGCAG GTCTGTGTGG 83640

CAGCGGACGA ACAGCGCCAG GAACTGCGGG TAACTCATCT TGAAGTACTG CAGCAGGTCG 83700

CGGCAGTGAA TCGTCGGAAT GTAGCCGGTG CTGATGTCCA ACACGATATC GCAGCCCATC 83760

AGCAGGAGAT CGGTATCCGT GGTATGCACG TACGCGACCG TGTTGGTATG ATAGAGGTTC 83820 GCGCAGGCGT CGTCGGCCTC CAGCTGACCC GAGTTGATGT AGGCGTACCC CAGCGCCCGC 83880

AGAACGCGGA TACAGAACAG GTGAGCCAGG CGCAGGGCCG GCTTCGAGGG CGCGCCCCAG 83940

GGGGCCGCCG GGCCTGGGCC GGCGGCCCGC GTTCCCCGGT CCCCCGGGGC GAAGGCGTGC 84000

CCGCGGCGGC GCATGTTGGA AAAAGGCGAA ACTGGGCCTG GAGTCGGTGA TGGGGGAAGG 84060 CGGCGGCGAG GCGTCTACGT CACTGGCCTC CTCGTCCGTG CGGCACTGGG CCGTCGTGCG 84120

GGCCAGGATC GCCTTGGCCC CGAACACAAC CGGCTCGGTA CACTCGACCC CGCGATCGGT 84180

CACGAAGATG GGGAACAGGG ACTTTTGGGT AAACACCCGT AACATACTAC AGAGACAGTG 84240

TAGCGTGATT GCCTCGCGGT CGTAACTTGG GTAGCGGCGC TGATATTTAA CCACCAGGGT 84300

ATACATGACA TTCCACAGGT CCACGGCGAT GGGGGTAAAG TAGCCCTCCG GGGCCCGGAG 84360 GCCCCGGCGC TTCACCAGAT GGTGAGTCTG GGCAAACTTC ATCATGCCAA ACAGACCCAT 84420

TCCGGCACGA TTGTAGGTGC GGATAGGTCT CTCTACAGAG CTGTATAGGT GTGACGGTCC 84480

GGGACACCCA AGCCCGCCGC CCCTGTGTAC AGTGGCTGCG GCGACGACCC CGCTCCAACA 84540

AGACGCTATC CCGGGAAAGG CACGCTCTTT ATAATTCTTT TTTATTTCCC ATCTACGTGC 84600

GGATTGGTGC AACCGCCGGC GCGCGCCGGT GCAGGCCGAC CATCTCTCTC TTCCCCCCCT 84660 CCCCCTCCCC CGAGCCCTCA AAGAGGGTGT GGCCTAACTA GCGGAAGGCG TATTTAACCA 84720

GACTAGGGCG GCGGGTCCGC CGTAGTCCTT GGCTCGGGTA GCCACTGCTC TGTGGCTCGG 84780

GTCCCCCGGC CCCCCTAACC CCCATCCGGT CCGCGTCATC CGCCCCCTCC GCCTGCGACA 84840

CAAACGGCCG CGCCTCCGGG CCCGGTGACA CGACGCGCCT CGTCTCTGCG GATTGTCCCG 84900

GGAGCGTCGC GGCATGGCTC ATCTTCCCGG CGGTGCGGCC GCCGCCCCCC TTTCGGAGGA 84960 CGCGATCCCG TCGCCGCGCG AGCGGACGGA AGACTGGCCG CCCTGCCAGA TAGTGCTGCA 85020

GGGCGCCGAG CTGAACGGGA TCCTGCAGGC CTTTGCGCCG CTTCGCACGA GCCTTTTGGA 85080

CTCGCTCCTG GTCGTGGGCG ACCGAGGCAT CCTTGTACAT AACGCGATTT TCGGCGAGCA 85140

GGTGTTTCTG CCCCTCGACC ATTCGCAGTT CAGTCGCTAT CGATGGGGCG GACCCACCGC 85200

GGCGTTCCTG TCTCTCGTGG ACCAGAAGCG ATCCCTGCTG AGCGTGTTTC GCGCCAACCA 85260 GTACCCTGAC CTGCGGCGGG TGGAGCTGAC GGTCACGGGC CAGGCCCCGT TTCGCACGCT 85320

GGTGCAGCGC ATATGGACGA CCGCGTCCGA CGGAGAGGCC GTGGAGCTTG CCAGCGAGAC 85380

GCTCATGAAA CGCGAGTTGA CGAGCTTCGC GGTACTACTC CCCCAGGGCG ACCCCGACGT 85440

CCAGCTGCGC CTCACGAAGC CCCAGCTCAC GAAGGTGGTG AACGCCGTCG GGGACGAGAC 85500

CGCCAAACCC ACCACGTTCG AGCTCGGCCC CAACGGCAAG TTTTCCGTGT TTAACGCGCG 85560 CACCTGCGTC ACCTTTGCCG CCCGCGAGGA GGGCGCGTCG TCCAGCACCA GCGCCCAGGT 85620

CCAGATTCTG ACCAGCGCGC TGAAGAAGGC GGGCCAGGCG GCCGCCAACG CCAAGACGGT 85680

CTACGGGGAA AACACACACC GCACATTCTC GGTGGTCGTC GACGACTGCA GCATGCGGGC 85740

GGTCCTCCGG CGGCTCCAGG TCGGCGGGGG GACCCTCAAG TTCTTCCTCA CGGCCGACGT 85800

CCCCAGCGTG TGTGTCACCG CCACCGGCCC CAACGCGGTG TCGGCGGTGT TTCTTTTAAA 85860 ACCCCAGCGG GTCTGCCTGA ACTGGCTCGG CCGGACCCCG GGTTCCTCGA CCGGGAGCTT 85920

GGCGTCCCAG GACTCTCGGG CCGGCCCGAC CGACAGCCAG GACTTCTCCT CCGAGCCGGA 85980

CGCGGGCGAC CGCGGCGCCC CAGAAGAAGA AGGCCTCGAG GGCCAGGCCC GGGTCCCGCC 86040

CGCGTTCCCG GAACCGCCGG GAACCAAGCG GAGGCACGCC GGGGCCGAAG TTGTCCCCGC 86100

GGACGACGCC ACCAAGCGCC CGAAGACGGG CGTGCCCGCC GCCCCCACGC GAGCCGAGTC 86160 GCCCCCCCTC TCCGCGAGAT ACGGACCCGA GGCGGCGGAG GGTGGTGGGG ACGGCGGCCG 86220

CTACGCGTGC TACTTTCGCG ACCTCCAGAC CGGCGACGCG AGCCCCAGCC CCCTCTCCGC 86280

CTTCCGGGGT CCCCAAAGAC CCCCATACGG CTTTGGGTTG CCCTGACGGC GACGGGTGGT 86340

GGCCGAACGC TTCACCGCGC CCGGGCACGC GGGGTGCGTT GTGTTAAAAA AATAAATAAA 86400 TGGGGTAGTG TGTCCCCCCC CTCCAACCAA TATGGCTGTC GTGTGTGGTT CCGGGTTGCG 86460

CCTCCGTCCT TTCCACCCCC CTTCCCCCTC CTTTTTTGTT TTGCGTGCGC TTATAAGAGC 86520

GGGCCCGGGG CCCTTCGCAG CTTCACCGAG AGCGCCGTCG GGCCCCGGGT GCGGGATGTG 86580

TCGCGGGGAC AGCCCCGGGG TCGCGGGCGG GAGCGGCGAA CACTGCCTCG GAGGGGATGA 86640 TGGGGACGAC GGGCGCCCCC GCCTCGCCTG CGTGGGTGCC ATCGCTCGGG GGTTCGCGCA 86700

TCTCTGGCTC CAGGCCACCA CGCTGGGCTT CGTGGGGTCT GTCGTTCTGT CGCGCGGCCC 86760

GTATGCGGAC GCCATGTCGG GGGCGTTCGT GATCGGGAGC ACCGGCCTGG GGTTCCTCCG 86820

CGCCCCCCCC GCGTTCGCCC GGCCGCCGAC GCGTGTGTGC GCGTGGCTGA GGCTGGTCGG 86880

CGGGGGAGCG GCCGTGGCCC TGTGGAGCCT CGGGGAGGCC GGCGCGCCTC CGGGGGTTCC 86940 GGGCCCGGCG ACCCAGTGCC TGGCGCTCGG GGCCGCCTAC GCGGCGCTGC TGGTGCTGGC 87000

CGACGACGTC CATCCCCTTT TCCTCCTCGC CCCGCGGCCC CTGTTTGTCG GCACCCTGGG 87060

GGTTGTCGTC GGCGGGCTGA CGATAGGCGG CAGTGCGCGC TACTGGTGGA TCGACCCCCG 87120

CGCCGCCGCG GCCCTGACGG CGGCGGTGGT GGCGGGCCTC GGGACAACCG CCGCCGGGGA 87180

CAGCTTTTCC AAGGCCTGTC CCCGCCACCG CCGCTTTTGC GTCGTCTCCG CGGTCGAGTC 87240 TCCCCCGCCC CGATACGCCC CGGAGGACGC CGAGCGGCCA ACAGACCACG GACCCCTGTT 87300

ACCGTCGACG CACCACCAGC GATCTCCGCG GGTCTGCGGC GACGGGGCCG CACGGCCCGA 87360

AAACATCTGG GTTCCCGTGG TGACCTTTGC GGGCGCGCTC GCGCTGGCCG CCTGCGCCGC 87420

GCGAGGGTCT GACGCGGCTC CGTCAGGCCC GGTCCTGCCG CTGTGGCCCC AGGTGTTTGT 87480

CGGGGGCCAC GCGGCGGCGG GCCTGACGGA GCTGTGTCAG ACCCTCGCGC CCCGGGACCT 87540 CACGGACCCG CTGCTGTTTG CGTACGTCGG ATTCCAGGTC GTGAACCACG GGCTGATGTT 87600

TGTGGTCCCC GACATCGCCG TATACGCGAT GCTGGGGGGC GCCGTGTGGA TCTCGCTGAC 87660

GCAGGTGCTT GGGCTCCGGC GCCGCCTTCA CAAGGACCCA GACGCCGGGC CCTGGGCGGC 87720

CGCGACCCTG CGGGGCCTCT TTTTCTCCGT CTACGCATTG GGGTTTGCGG CGGGGGTGCT 87780

GGTGCGGCCG CGGATGGCGG CGAGCCGGCG GTCGGGGTGA TCGCCATTTC AAATAAAAGG 87840 CACGAGTTCC CCGAATACCA CCGGCGTGTG ATGATTTCGC CCTACCGCTC CGATCCCCGG 87900

GGGGAGGGGG GAAGGAAATG GGGGCGGGGG TGCCGTGGAC GGGTATAAAG GCCAGGGGGG 87960

CAGGCGGGCC CATCACTGTT AGGGTGTTAG GTTGGGAGGT GGCACAAAAA GCGACACACC 88020

CGTGTTGTAG TTGTCCGCGG GAGGCGGTGG TTTCCGGCAA CCCTCCTCGC TGCGCCGGGC 88080

GCGCCCACCG GTCCTTCGCG GGGGCCGGGG CTCTTCTGGT CATGGCCCTT GGACGGGTGG 88140 GCCTAGCCGT GGGCCTGTGG GGCCTGCTGT GGGTGGGTGT GGTCGTGGTG CTGGCCAATG 88200

CCTCCCCCGG ACGCACGATA ACGGTGGGCC CGCGGGGGAA CGCGAGCAAT GCCGCCCCCT 88260

CCGCGTCCCC GCGGAACGCA TCCGCCCCCC GAACCACACC CACGCCCCCC CAACCCCGCA 88320

AGGCGACGAA AAGTAAGGCC TCCACCGCCA AACCGGCCCC GCCCCCCAAG ACCGGGCCCC 88380

CGAAGACATC CTCGGAGCCC GTGCGATGCA ACCGCCACGA CCCGCTGGCC CGGTACGGCT 88440 CGCGGGTGCA AATCCGATGC CGGTTTCCCA ACTCCACCCG CACGGAGTCC CGCCTCCAGA 88500

TCTGGCGTTA TGCCACGGCG ACGGACGCCG AGATCGGAAC GGCGCCTAGC TTAGAGGAGG 88560

TGATGGTAAA CGTGTCGGCC CCGCCCGGGG GCCAACTGGT GTATGACAGC GCCCCCAACC 88620

GAACGGACCC GCACGTGATC TGGGCGGAGG GCGCCGGCCC GGGCGCCAGC CCGCGGCTGT 88680

ACTCGGTCGT CGGGCCGCTG GGTCGGCAGC GGCTCATCAT CGAAGAGCTG ACCCTGGAGA 88740 CCCAGGGCAT GTACTACTGG GTGTGGGGCC GGACGGACCG CCCGTCCGCG TACGGGACCT 88800

GGGTGCGCGT TCGCGTGTTC CGCCCTCCGT CGCTGACCAT CCACCCCCAC GCGGTGCTGG 88860

AGGGCCAGCC GTTTAAGGCG ACGTGCACGG CCGCCACCTA CTACCCGGGC AACCGCGCGG 88920

AGTTCGTCTG GTTCGAGGAC GGTCGCCGGG TATTCGATCC GGCCCAGATA CACACGCAGA 88980 CGCAGGAGAA CCCCGACGGC TTTTCCACCG TCTCCACCGT GACCTCCGCG GCCGTCGGCG 89040

GCCAGGGCCC CCCGCGCACC TTCACCTGCC AGCTGACGTG GCACCGCGAC TCCGTGTCGT 89100

TCTCTCGGCG CAACGCCAGC GGCACGGCAT CGGTGCTGCC GCGGCCAACC ATTACCATGG 89160

AGTTTACGGG CGACCATGCG GTCTGCACGG CCGGCTGTGT GCCCGAGGGG GTGACGTTTG 89220 CCTGGTTCCT GGGGGACGAC TCCTCGCCGG CGGAGAAGGT GGCCGTCGCG TCCCAGACAT 89280

CGTGCGGGCG CCCCGGCACC GCCACGATCC GCTCCACCCT GCCGGTCTCG TACGAGCAGA 89340

CCGAGTACAT CTGCCGGCTG GCGGGATACC CGGACGGAAT TCCGGTCCTA GAGCACCACG 89400

GCAGCCACCA GCCCCCGCCG CGGGACCCCA CCGAGCGGCA GGTGATCCGG GCGGTGGAGG 89460

GGGCGGGGAT CGGAGTGGCT GTCCTTGTCG CGGTGGTTCT GGCCGGGACC GCGGTAGTGT 89520 ACCTCACCCA CGCCTCCTCG GTGCGCTATC GTCGGCTGCG GTAACTCCGG GGCCGGGCCC 89580

GGCCGCCGGT TGTCTTCTTT TCCACCCCTT CCGTCCCCCG TACCCACCAC ACCCCACCCC 89640

ACCCCCCCGC CGTCCCCCGG GCGTTATAAG CCGCCGCACT CGCTTTTCCC ACCGGAAAAT 89700

CCTCGGCCCG ATCCGAACGG CGCACGCCGC GTGGGCTCCA AACGCCTCCG GAAGAGAGCG 89760

CCCCGCCCCG ATATTCAAGC CCGCGGTGGT GCTATGGCTT TCCGTGCTTC GGGACCCGCC 89820 TACCAGCCCC TCGCCCCCGC GGCCTCCCCG GCGCGGGCTC GTGTTCCGGC CGTGGCCTGG 89880

ATCGGCGTCG GAGCGATCGT CGGGGCCTTT GCGCTCGTCG CCGCGTTGGT TCTCGTACCC 89940

CCTCGGTCCT CGTGGGGACT CTCGCCGTGC GACAGCGGCT GGCAGGAATT CAACGCGGGA 90000

TGCGTCGCGT GGGACCCCAC CCCCGTCGAG CACGAGCAGG CGGTCGGCGG CTGCAGCGCG 90060

CCGGCCACCC TTATCCCCCG TGCGGCCGCC AAGCACCTGG CCGCTCTGAC ACGCGTCCAG 90120 GCGGAGAGAT CGTCGGGTTA CTGGTGGGTG AACGGAGACG GCATCCGGAC CTGTCTGAGA 90180

CTCGTCGACA GCGTCAGTGG CATCGACGAG TTTTGCGAGG AGCTCGCGAT CCGCATATGC 90240

TACTACCCAC GAAGCCCCGG CGGGTTTGTC CGCTTCGTAA CTTCGATACG TAACGCCCTG 90300

GGGTTGCCGT GAGGCGCGCG TCCGACGGTC CCGCTTCTCG CCTCTCTTCT TCCCCCTCCC 90360

CACCCCACCC ACCGACCAAC GACGGCGTTT GGCCAATACC CTCCTTTTTT CTTTTTCTCT 90420 TCCCCCCCCA AAAAAAAAAA CAATAAACAG CTAATTGCGT ACGACAAACC ATGCGGAACT 90480

CGCTGTTTTT TTTTCTCTGT TTGTTACTTT TTATTGAAAA CAGACATACG GGGAAAGGGG 90540

CCGGAAACCG AGACGGTGGG GCCGGCGGTC GCATTTTTTT AATGGCTCTG GTGTCGGCCG 90600

CGTTTGAGCT TCGTCAACAG GGCGCTGAGG GCGGCGACGT TTGTCGGGCC GTCGTTGGCC 90660

AGCGCGTTGG TCCGGGGGCG GGCGGGCATG GGCGACAGGC TTAGTCCCGG GTCCGGGGCG 90720 CGTGTGGCCC CCGGAGGGGA GAAGAGGGCA GACCCGCCCC AGTCGTACAG GGGATTTTCC 90780

GCCTCGATGT ACGGGGAGTC CGGGGCGTCT CCCGGCGGGG CCGCCCCGCC GGCGTCTTGC 90840

CGGCGAAGGC AGATGTTTTC GTATACCCGA ACCCAGGGGA TCTCCTCGTA GACGCGCCCC 90900

CCATCCTCGC TCACCGACTC GTAAATGGAA TCTGCGTCCT CGGAGGGGGC GCGGGGGGCG 90960

TGGCTTTCGG CCGGCCAGGC GGCGGCGGTG GTGTCGGCGG CGGGGGTGGC GCCAAGCCCG 91020 ACGCCCGCGG GCATGGCGGC GTCATCGTCG GGCAGCAGAT ACGTGTTTTC CATCTGGTCC 91080

GGTTCGGCCT CCGCGTCTGG CCCCCAGGTC CGCACCGCGT CGTAAACCCC GGCGGCCTCG 91140

CGCTGAGCCG CGAGCGGGCG CGCCGCGGCT GCCGGCCGCT GCTCGGGGGG CGCGGGGTTG 91200

CGGGGCGGGA GGCGCGGGGG CGCCCCGGCC ATATGCGTGT AATACGTGGC CGGCCGGCCG 91260

GCGCAGGGCT CGGGACCCCG GTCGGCCGCG TCGACGTGCG GGGGCTCGGG GAGGTCCTCG 91320 CGGTGGCGCC TGAACCTCCG AGGGGCCGCG GGGGTCGAGT GGGGGCGAGC CCGGGGGAGC 91380

GGCGGGGGTG CGTTATCGCG CCGGGTCCGT TGTATCTTGT CCCGGCAGCT CCCGCCGACC 91440

GCGCCGCGGC CCCCCGGTGG GCCGGACGCC GCGAGGCGCA GGATGGACTC GTAGTGGGGC 91500

GACGGGGTTC CGCTCCGAAG CAGGTCCGGG GCCAGGGCGG CCCCGAACCA GGACTTGATG 91560 CTGAGTTCCA TCCGGGCCCA GCTCGGGGCG GTCATCGTGG GGAACAGGGG GGCGGCGGTC 91620

CTGCAGAAGC GCTCCTGGCT GTCCACCGCC GCCCGTAGGT ACTCGTTGTT CAGGCTGTCG 91680

GAGGCCCAGA CGACATACCC GGTAAGCGTC GCGTTAATTA TATACTGGGC GTGGTGGTGG 91740

ACTATGGATA GAACCTCGAC GGTCGAGACG ATGGCGTCCA CGATCCCGTA CGTGCCGCCG 91800 CTGCGCTTGC CGGTCTCCCA CAGGTGGGCC AGGCGCGTCA GGTGGCCCAG GACGTCGCTG 91860

ACCGCCGCCC GCAGGGCCAT GCACTGCATC GAGCCCGTGG TGCCGCTGGG CCCGCGGTCC 91920

AGGTGGCGCG CAAACGTCTC CGCGGGCGCC TCCAGACTCC CGCTGAGCGC CACGAACCGG 91980

CGATCGGCGG GGCCCAGGCG GCGACACACG TACTTGTCCG CCGTCCACAG CATCCACGAG 92040

GCCCAATGGT ACAACACGGA GACGTAGGCC AGGAACTCGC TCAGCCGCAG TGCGGTGTCC 92100 GTGCTCGGCC GGCTCGGGTC TGCGGGGCGC ATAAAGAACA TGTACTGCTG GAGCCTGTGG 92160

GCCGCGTCGC GCAACCCCGC CACCGCGGCG GCGTACTTGG CCGCGGCGGC CCCGCTCTTG 92220

AACGGGGCGC GCACCAGCAG CTTCGGGAGC AGGGTGGGCC GCAGCAGCAC GTGCAGGCTG 92280

GGGTCGCAGT CGCCCGCCGG GTCGTCGGGG ATGTCCAGGC CGCTGGGCAC GACCGTCTGG 92340

AGGTACTTCC AGTACTGCGC TAGGATGGCG CGGCTCAGCT GGCCGCCCGA CAGCTCCACC 92400 TCGCCGAGCG CCTGCTTGGC GGCCGACGCG TAGTGCCGGA TGTAGTCGTA GTGCGGGTCG 92460

CTGGCGAGCC CGTCTACGAT CAGGCTCTCG GGGACGGTGT TATGGTGCCG CGCCGCCAGC 92520

CGGACGCTGC GATCGGCGCC GGTCAGAAAC GCCGGCTGCA GGTCGTCGGC GCGCTGCCGC 92580

AGGACGCCCA CGGCCGCGCT GAGGAGCCCC TCCGGGGTGG GGAGCAGACA CCCGGCGAAG 92640

ATGCGCCGCT CGGGGACGCC CGCGTTGGCG CCGCGGATGA GGTTGGCCGG CGTCAGGCAC 92700 CGCGCCAGCC GCAGGGAGCT CGCGCCGCGC GCCCGGCGTT GCATGGCGGA GACCGTTCGG 92760

TCGGGGGCCC GCCGGTCGGA GGTATGCCGC GTCCCGGGAT ATAGGGTTGC TTTTTATGGG 92820

GAGGCGCCTA TGGGCGTGGC GGGCCGCCCA GCCCGGTCGC GCGCCTCCCG GACACGTGCG 92880

CCCGGAGGGC GGCGGTCTCC TCGTCGCCCA TGAGCAGTTT CCGAAACTGC GCCATGATGT 92940

CCACGACGCG GACCCGCGGC CCCAGCACGG ACTCGCTATT CAGGGGGGCG GGGGGGAAGG 93000 CCGCCAGGTC TTCGAGCAGG AAGGCGGGGT CTGCCGTCCC GCTCACGGGC GCCCGGGGCG 93060

CCGAGGACGC GGGGCGAAGG TCCACGTGTT CCGCGGCGGC GCGCACGTCC GCCCAAAATT 93120

TGGCGGGGGT GGTCCGCGCG TACAGGGGCT GGGTCGCGCG GAGGACGCAC GCGTAGCGCA 93180

GGGGGGTGTA CGTGCCCACC TCGGGGGCCG TCGACCCGCC GTCAAACGCG GCCAGGGCCA 93240

CGCACGCGAC CACCGTGTCG GCCAGGCCCA GCAGCCGCTG CAGGATGAGC CCCGTCGCCA 93300 GCACGGCGCG CGCGGCCGCC GCGTGGTCCC TGCGCCGGCG CGCGTCCCCG CAGGCCAGGG 93360

CGTATTTCAG GGTAACGGTC GCCAGGGCCG TGTGCAGCGC GTACACGGCC GCGCCCAGCA 93420

CGGCGTTCAG CCCGCTGGTG GCGAGCAGGC GGCGCGCCGC GGTGTCGCCC AGCGCCTCGT 93480

GCTCGGCCGC CACGACCCCG GGGCTACCCA GGGGCAGGGC GCGAAACAGC GCCTCCTGCT 93540

CCACGTCCAC AAACGCGGGG TGGGCGGAGT GCGGGTGCAG GCGCGCCCCC ACGACCACCG 93600 AGAGCCACTG GACCGTCTGC TCCGCCAGGA CCGCCAGCAC GTCCAGGACG CGCCCCGCAA 93660

ACGCGGCCTC CCGCGGGAGC ACGCATTTGA CGGCGCCGGG GTTGAAGCGG GCGAGCAGAG 93720

CCCCGGTGGC GATGTACGTC ATGCGCCCCG CGTAGCGGGC GGCCACGCGA CAGTCGCGCC 93780

CCAGGAGCGC GCGCACCCCG GGCCAGTACA GCAGGGACCC CAGCGAACTG CGAAAGACCG 93840

CGGCGTCGGG GCCGGGGTGG GGGGGCGCGG CCCCTCCCGC GCTGAGCAGC GGCACGGCGG 93900 CGGCCCCCAC GGGCCGCAAC GCCGTGAGGC TCGCGAACTG CCGTCGGAGC TCGGCCGCCC 93960

TGTCGTCGAG CTCCGAGCCG CGCGCCCTCC GTGTGCAGGC GCGTCCCGCA GACCCACCCG 94020

TTGATCGCCA CCCGCACGAT GGCGTCCACC AGAAAGCCCA TCGCGCGGGA GGGGCTGGTT 94080

TTTGCCCGCC GATCCGTCAG GTCGAGGATC GCGTCGCCCG TGACGTACCA GGCCAGCGCC 94140 TCGCCCTGCT GCAGCGTCTG GCGGAAAAAC ACCTTTGGGT CGGCCGGGGA GGCAAAGTGC 94200

ATGACCCCCA CGCGCGACAG CCCGAACGCG CTATCCGGAC ACGGGTAGAA CCCGGCCGGA 94260

TGTCCCAGGG CCAGGGCCGA GCGCACGGAC TCGTCCCACG CGGCGACTCG GGGGGTCAGG 94320

CGGTCCAGGG GGAATGCCGC CTGCAGCTCC GGGCCCGACA CGCGGCCCGC GAGAATCTCG 94380 ACCGTCGCGG GAGGCCGCGC CCCGGCGCCG TCATCGTGCG CGACGGCGGC GGGGTAGTCG 94440

TCCTCCTCGT AGCTGAGCTC GTCCAGGAAC AGCGGCGAGG GCACCACCCG CGAACCGCCC 94500

ACCCGCCCCA AAACGTCGCG TGGGTCCATC GGGCCCAGGT AGCCTCCCCG CGGGGCCCGC 94560

GTGATGGCGC TGTCCCGGCG TCCGCGAACG GACTGGCTCC TGGCCGTAAC GGACCTGGGG 94620

CGCGGAAAGG ACGCCCGGCG GGGGGGCGCC GCCGCCCGGG CCTCGGACGC GCGTCGGGAC 94680 CCGGGGTGAC CGCGGGCCTC CCGGCGACGG CGCGGGGGCG GCTCTTCGCT CGCCATCTCC 94740

CCCGCGGCCT CGACCTCGCT GTCGTCGTCC ACGTTAAACA CCGCCCGCAG GTACCCCATT 94800

AACCCGACTC CACCGCCCTC GGGCTCGTCC TCCACGGGCG AGTCGGCGCG ATGCGCGGAC 94860

GGGGCATGGG ACCGGGTGGA GGCGCGCCTC CGGCGTACGG CATGCCCGCG CACGGACATG 94920

GTGGCCGGAG GCCCGATTTT TTACACACGC CCTCCCCGCA GACGGACGAG GAAAGGGGTG 94980 GTGCGAGGGG GGAGGCCCAA ACGGGGAGGT GGGGGGTAGG GGGCGGTCCC AGGGAGCGGG 95040

GGGTAGGAAC CGGCACGACG GGAACAGAGA AACGCGACCG CTCCAACAAG GGTGGGGGGT 95100

GGGCCTCGTC CCCACGCAGA CCCGCGGGCA AATGCGAGAA CGGGACCCGC GCGCCTGCCT 95160

TTATACGCGG ACCCCAGCAC CACGAGCCGT TCTGTGACGC GAATCTACAC GACCGCGGGC 95220

TCGTAGGCGC GACTAACGCC CAACCCAACG GCACACACCC CCCACCCCGC GCGTAACCCC 95280 ATTTCTTTCA TGGTCCCGTA ATAAACAGCC AACGCACGCC GCGTATGATG AGTTGCTTGC 95340

CAATGTTTAT TGCTGTGGTT GCGAACCCTC TATCGCGATA CAGACGGAAG TGAGGCGGGG 95400

CGGTGGTGGG GGGGGGGGGC GCGCCGCCCG GTCGCACATC CTACCCCCCA AAGTCGTCAA 95460

TGCCCATGGC ATCGGTAAAC ATCTGTTCAA ACTCAAAATC GTCCACGTCC AAAGCCCCAT 95520

ACGAGACGGG GTCGTGGGTC ATTCCCGGGG AGGGGGACTC CACGTCCCCC AGCATCTCCA 95580 AGTCGAAGTC GTCCAGGGCG TCGGCGGGCG TCATATCCAC CTCCTCGCCG TCCAGGCGGA 95640

GTTCGTCTCC CAGGCTGACG TCGGTAATGG GGGCGGTGGT GGACAGTCTG CGGGGGCGTT 95700

GTCCCGCGGA GAGAAACGAC ATGCGCGGCG CCACCAGCCC GGCCTCCGCG GGAGCGTCAT 95760

CGTCGTCCGG GAGGTCGAGC AGGCCCTCGA TTGTCGATCC GTAATTATTT CTGGTCCGCC 95820

CGCGGCTATA CGCGTGCTCC CGCATGACGG ACTCGCCCTC CGAGGTCGCA ACGCTGGAGT 95880 ACGAGTCCAA CTTGGCCCGG ATCAGCAGCA TAAAGTACCC AGAGGAGCGG GCCTGGTTGC 95940

CCTGCAGGAC GGGCGGGGTC GTGAGGGGCG CCCCGGGTTC CTCCGCCGCC GCACTTCGCA 96000

CCAGCGGGAG GTTCAGGTGC TCGCGAATGT GGTTTAGCTC CCGCAGTCGC CGGGCCTCCA 96060

CGGGAACTCC CCGCACGGTG AGCGATCCGT TGATAAACAT CAGGGGCTGA AACAGACACG 96120

CCAACTGGCG CCAGCTCTCC AGGTCGCAGC AGAGGCCGTC GAACAGATCG GGCCGCATCA 96180 TCTGCTCGGC GTACGCGGCC CATAGGATCT CGCGGCTCAG AAAGAGGTAT AGATGCAGAA 96240

ACAGGACGCG CGCCAGGCGC GCGGTCTCGC GGTAGTACCT GTCCGCGATC GTGGTGCGCA 96300

GCATCTCCCG CAGGTCGCGG TTGCGGCCCC GCATGTGTGC CTGGCGGTGT AGCTGCCGAA 96360

CGCTGGCGCG CAGGTACCGG TACAGGGCCG AGCAAAAATT TGCCAACACG GTCCGGTAGC 96420

TCTCCTCCCG CGCCCGCAGC TCACCGCGGA AAAACTGCGC CATGGCCTCG TAGTACGAAG 96480 GCAGCTCGTC GCGGGTGGCG GGCAGGGTGG GGAACGCCAC GTCGCCGTGG GCGCGAATGT 96540

CGATCGGGGA GCGCTCGGGG ACGTGCGCAT CCCCCCAGTC GATCACGTCG CTGGGCAGCG 96600

TCGACAGAAA CTTGCACTCC CGGTACATGT CGGCGTTGGT CGGGAACCCA GAGAACAGGT 96660

CCTCGTTCCA GGTATCTAGC ATGGTACACA GCGCGGGACC CGCGCTGAAG CCCAGATCGT 96720 CGAGGAGACG GTTAAACAGG GCCGCGGGGG GGACGGGCAT GGGCGGCGAG GGCATCAGCT 96780

GGGCCTGACT CAGCCGACCG GTGGCGTACA GCGGAGGGGC GGCTGGGGTG TTCTTGGGAC 96840

CCCCGGCTGG CCTGGGGGGC GGTGGCGAAA CCCCGTCCGC GTCCGCAAAC AGATCGTCGA 96900

CCAACAGGTC CATGGGGGCG GTTGGGTCCG GGAATAACGA TCTCGAGAGG CGAATGAGAC 96960 GTGCCCGAGC GCCCGGCGGC GGAGAGGGGG GGAGGGATCC GGGACCCGCG ACAGAAAAAG 97020

GCCGGGGCCC TCGCGAAGGG AATCGCCGGG GGTGCCGTGC GTCCCCGAGG ACTGACATCT 97080

CGCGTCCACC ACCCCGCATT TAAGTATCAC CCCAGTGCCG CCCCAAACCT CGTGACTTCC 97140

CCACCGCTCC GGGCGGCCCG TCCCCCGCGC TCGGAAGGGA GGCGTGTCGC CCCTCCCGCC 97200

CCTCCCGCCC CTCCCGCCCC TCCCGCCCCT CCCGCCCCTC CCGCCCCTCC CGCCCCTCCC 97260 GCCCCTCGCC ACAAACGCGT GCTGACAGCG AAGTGGTTAA ATCGACCGTG ATGCTTTATT 97320

GTCTGTCGTC TGAACGCGGC CGGGGTCGCT ACTCGAGGGG GCGGCGGGGA CGGGAAGCCG 97380

AGCGGGCGGG GGCCCGTGCG GTCGCGGCGG CACGCCCCGC GGGGCGGCCC CGGGCGGCCG 97440

CGGTCGCGTC GACGTCCTGC GCCGCGTCGG GATTCACCAA CTCGTTCGCG CGCTGCAGGA 97500

GGTTCTTGCC CTCGCAGACC GTCACGCGAA TGGTGGTGAG GTCGAGGAGC TCGTTGAGGT 97560 CTTCGTCGGT GTGCGGCCGC GACATGTCCC ACAGCTGTAC CGCCGCCAGC CGGGCGTGCG 97620

TGGCCGCCAG GCGCCCGACC GCGGCGCAGA AGACGCGCTT GTTGAACCCG GCCACCCGGG 97680

GGGTCCACGG CGCCGTGGGG CTCGGTGGGG CGGTGCTGAA GTGCAGCTTC TTGGCCAGTC 97740

CCTGGGCGGG TGTCTTGGTT CTTCCCGAGG CCGTGGGAGC GGGGGCGTCT AGGAGCACGG 97800

CGGAGTCGGC CTGGGCGGGT CGCCTGCCGC GGGCAGGGTC GGTCGCCGGG GTCGCGGGGG 97860 CCTTAGGCGC CCCGCGCGTC ATTTTGGGGG TCCGCGCGGG AGGGGCGTGC GAGCGCCCGC 97920

CGGCGCCCAC GGGGCCCCCG GGGGGTGGAG GAGCGCGCGC GGGGCCGGGG CCGTGAGAGC 97980

CCGCGACGGA CGCCGAACGA CGCGGTCGCG CGGTATCCCG GGACTCGTCG TTGTCTTCGG 98040

ACGACGACGA GTCCCGGTAG AGGGCATACC CAGCCTCGTC ATAATGGAGA AAGCGAACCT 98100

CGCCCCTTGG GCGCGCGCGC ATCGGGCCAG CGCCGCGGCG GAAGTCGTCG CGCGGACTCT 98160 CTGGATCCGC CGGGGAGACC GGGCCATAGT ACAGCTCCTC GTGGGTCCCG CGCGGCGCTT 98220

CCCGCGGACA CGACTTGACG GAGCGGCGAG AGGTCATGGT CTATCGGAGA CACCGGGGAC 98280

GCCCGTGCGG ATCACAGGGA AGGCGTCGGC GAAGCAGGCA GAGAGCGTCG GAAGGCGGCG 98340

AGGGAGGGAA AGAGGGAGAC CGGCGGGGTA CGGGAGAGCA GCGAGGGCCT GCGTAACCCA 98400

CGGGGGCCGC GGGAGTGGCT CCCTGCGGGT TGCGGGGGAG AGTTTATAGG AAGTGGATAT 98460 AACCGCAGGC GACGGGACTA ACCAATCCCC GGGGGGGCAA CGGACAGACA CGCCCCGAAC 98520

CGGCCCGACT TCCGCGAGGA AGCAAAGGCC GGGGGCCGCC CAACGACACG CCCACCCCTT 98580

CCCAACAGGG CGGGCTCAGG CTGACCCGGC GGCCAGTGCC CGCTGGCATA TCTGATACAC 98640

GTGCGCGATC ATACATACGC CCATCGAGGT CATGCCTAGA TAAAAGGGCA CCAGGACCCC 98700

CGGGACGGAC ACCACACCGG CGCTGTCGCC CCGGCATTGC GCGTCCCCGA TAACGCCGCG 98760 TGCGCCTGCC GCGTTCGGCG GCTCCCCGGG CACGCCCGCG ACGAGCGCGA CGAACAACAG 98820

CACCACCCAG CGGCCCAGTC TTGCGGGTTT CCCCGTCATC GCGGCGATGA GTCAGTGGGG 98880

GCCCAGGGCG ATCCTTGTCC AGACGGACAG CACCAACCGG AATGCCGATG GGGACTGGCA 98940

AGCGGCCGTA GCTATTCGCG GGGGCGGAGT CGTTCAACTG AACATGGTCA ACAAACGCGC 99000

CGTGGATTTT ACCCCGGCAG AATGCGGGGA CTCCGAATGG GCCGTGGGCC GCGTCTCTCT 99060 GGGCCTGCGA ATGGCAATGC CGCGTGACTT CTGCGCGATT ATTCACGCCC CCGCGGTATC 99120

CGGCCCCGGG CCCCACGTGA TGCTCGGTCT CGTCGACTCG GGCTACCGCG GAACCGTCCT 99180

GGCCGTGGTC GTAGCCCCGA ACGGGACGCG CGGGTTTGCC CCCGGGGCCC TCCGGGTCGA 99240

CGTGACGTTT CTGGACATCC GGGCCACCCC CCCGACCCTC ACCGAGCCGA GCTCCCTGCA 99300 CCGGTTTCCG CAGTTGGCGC CGTCCCCGCT GGCAGGGTTA CGAGAAGATC CTTGGTTGGA 99360

CGGGGCGCTC GCGACCGCCG GGGGGGCGGT GGCCCTGCCG GCCAGACGGC GCGGGGGATC 99420

GCTGGTCTAC GCGGGCGAGC TAACGCAGGT GACCACCGAG CACGGCGACT GCGTGCACGA 99480

GGCGCCCGCC TTTCTGCCAA AGCGCGAGGA GGACGCAGGC TTTGACATTC TCATCCACCG 99540 AGCCGTGACC GTCCCGGCCA ACGGCGCCAC GGTCATACAG CCGTCCCTCC GCGTATTGCG 99600

CGCGGCCGAC GGACCAGAGG CCTGCTATGT GCTGGGGCGG TCGTCGCTCA ATGCCAGGGG 99660

CCTCCTGGTC ATGCCTACGC GCTGGCCCTC CGGGCACGCC TGTGCGTTTG TTGTATGTAA 99720

CCTGACCGGA GTCCCGGTGA CCCTACAAGC CGGGTCCAAG GTCGCCCAGC TGCTCGTCGC 99780

GGGGACCCAC GCCCTCCCCT GGATCCCCCC CGACAACATC CACGAGGACG GCGCATTCCG 99840 GGCCTACCCC AGAGGGGTTC CGGACGCGAC CGCCACCCCC CGAGACCCGC CGATTTTGGT 99900

GTTTACGAAC GAGTTTGACG CGGACGCCCC CCCAAGCAAG CGGGGGGCCG GGGGGTTTGG 99960

CTCCACTGGC ATCTAGACCG CGCCTCGCGT CGGGCCAGAT GGGGCCCCGG TCAATAAAGA 100020

GCTCTGTTTC GCATATGCCC TGGTGTTGGC GGTTTTTTTT TTGTTGTCTG TCTGCCCGGC 100080

ACTCGGTTGT CCGTTCTGTC GTCGCTATCA CA ACGCACA AACACACGGG TAGAGTGGAA 100140 CCGAAACCGG TCGACGTTTA TTCACCACAC AGAAACACAA GCTAAGCGAG AAGGAGGGGG 100200

GCCTCGGTCG ACGAGGCCTG GCGTTTGGGG GCGGACGTGC GATGACGTGG GTCCGGTGTA 100260

GGGTCCGCGG GGGGCACGGG CCCGGGGCGA ACGGGGGATC TGTCGCCGGC GTGGGTGACT 100320

GGGACCGACG CAACCTCCGG GGCTTGTGCC CTCGTAGGCC CGGGGGGGGC CTCGGTCGCT 100380

CCGAGCCCCG CGGTGCGGGT CCCTCCGGCC AGAGCCGAGG TGGAGAGACC AAGGGCCCGC 100440 TCCGCGATCG CCACGTCCTC CATGACCACG TCGCTCTCGG CCATGCTCCG AATGGCCTGG 100500

GAGACGAGCA CGTCCGCCGA CTTGTCCGCG GCCCCCACCG ACATGTACAT CTGCAGGATG 100560

GTGGCCATGC ACGTGTCCGC CAGGCGGCGC ATCTTGTCCC GATGCGCCGC AACGGCCCCG 100620

TCGATGGTGG AGCCCTCGAG TCCCGGGTGG TGGCGCGCCA GCCTCTCGAG GTTGACCATG 100680

CAGGCGTGGT ATGTGCGGGC CAGGGCGCGC GCCTTCACGA GGCGCCGGGT GTCGTCCAGC 100740 GACTCTAGGG CGTCGTCGAG CGTGATGGGG GCGGGCAAAA GCGCATTGAC CACCGCCAGG 100800

GCCTCCTGCA GCCGCGGGTC CNNNTCCGAG GGCGGAGCCG CGGCCCGAAT CATCTCATAT 100860

TGTTGTTCCT CGGGGCGCGT TCCCCAACCG CACAGCACCC CGAGCAGGGA CGCCATCCCG 100920

GAACACGCGC GCGGCTCTGC GCCGGCTTTC CCCCACCCCA CCCCCTCCGG GTTCGCAGGG 100980

GCGATGGGGA CGGAAGACTG CGATCACGAA GGGCGGTCGG TTGCGGCTCC CGTGGAGGTT 101040 ATGGCGCTGT ATGCGACCGA CGGGTGCGTT ATCACCTCCT CGCTCGCCCT CCTCACAAAC 101100

TGCCTGCTGG GGGCCGAGCC GTTGTATATA TTCAGCTACG ACGCGTACCG GCCCGATGCG 101160

CCCAATGGCC CCACGGGCGC GCCCACCGAA CAGGAGAGGT TCGAGGGGAG CCGGGCGCTC 101220

TACCGGGATG CGGGGGGGCT AAATGGCGAT TCATTTCGGG TGACCTTTTG TTTATTGGGG 101280

ACGGAAGTGG GCGTGACCCA CCACCCGAAA GGGCGCACCC GGCCCATGTT TGTGTGCCGC 101340 TTCGAGCGAG CGGACGACGT CGCCGTGCTC CAAGACGCCC TGGGCCGCGG GACCCCATTG 101400

CTCCCGGCCC ACATCACAGC AACTCTGGAC TTGGAGGCGA CGTTTGCGCT CCACGCTAAC 101460

ATCATCATGG CTCTCACCGT GGCCATAGTC CACAACGCCC CCGCCCGCAT CGGCAGCGGC 101520

AGCACCGCTC CCCTGTATGA GCCCGGCGAA TCGATGCGCT CGGTCGTCGG GCGCATGTCC 101580

CTGGGGCAGC GCGGCCTCAC CACGCTGTTC GTGCACCACG AGGCGCGCGT GCTGGCGGCG 101640 TACCGCCGGG CGTATTATGG GAGCGCCCAA AGCCCCTTTT GGTTTCTGAG CAAATTCGGC 101700

CCGGACGAAA AGAGCCTGGT GCTGGCCGCT AGGTACTACG TACTCCAGGC TCCGCGCTTG 101760

GGGGGCGCCG GAGCCACGTA CGATCTGCAG GCCGTGAAAG ACATCTGCGC GACCTACGCG 101820

ATCCCCCACG ACCCACGCCC CGACACCCTC AGTGCCGCGT CCTTGACCTC GTTCGCCGCC 101880 ATCACTCGGT TCTGTTGCAC GAGCCAGTAC TCCCGCGGGG CCGCGGCCGC TGGGTTTCCG 101940

CTGTATGTGG AGCGCCGCAT CGCCGCCGAC GTACGCGAGA CCGGCGCGCT GGAGAAGTTC 102000

ATCGCCCACG ATCGCAGTTG CCTGCGCGTG TCCGACCGGG AATTCATTAC GTACATCTAC 102060

CTGGCCCACT TTGAGTGCTT CAGCCCCCCG CGCCTGGCCA CGCATCTCCG GGCCGTGACC 102120 ACCCACGACC CCAGCCCCGC GGCCAGCACG GAGCAGCCCT CGCCCCTGGG TCGGGAGGCG 102180

GTGGAACAGT TCTTCCGGCA CGTGCGCGCC CAGCTGAACA TCCGCGAGTA CGTAAAGCAA 102240

AACGTCACCC CCAGGGAAAC CGCCCTGGCG GGAGACGCGG CCGCCGCCTA CCTGCGCGCG 102300

CGCACGTATG CCCCGGCGGC CCTCACGCCC GCCCCCGCGT ACTGCGGGGT CGCAGACTCG 102360

TCCACCAAAA TGATGGGACG TCTGGCGGAA GCAGAAAGGC TCCTAGTCCC CCACGGCTGG 102420 CCCGCGTTCG CACCAACAAC CCCCGGGGAC GACGCGGGGG GCGGCACTGC CGCCCCCCAG 102480

ACCTGCGGAA TCGTCAAGCG CCTCCTCAAG CTGGCCGCCA CGGAGCAGCA GGGCACGACG 102540

CCCCCGGCGA TCGCGGCTCT CATGCAGGAC GCGTCGGTCC AAACCCCCCT GCCCGTGTAC 102600

AGGATTACCA TGTCCCCGAC CGGCCAGGCG TTTGCCGCGG CGGCGCGGGA CGACTGGGCC 102660

CGCGTGACGC GGGACGCGCG CCCGCCGGAA GCGACCGTGG TCGCGGACGC GGCGGCGGCG 102720 CCCGAGCCCG GCGCGCTCGG CCGGCGGCTC ACGCGCCGCA TTTGCGCCCG GGGCCCCGCG 102780

CCTCCCCCCG GGCGGCCTGG CCGTCGGGGG CCAGATGTAC GTGAACCGCA ACGAGATCTT 102840

CAACGCCGCG CTGGCCGTTA CGAACATCAT CCTGGATCTG GACATCGCCC TGAAGGAGCC 102900

CGTCCCCTTT CCCCGGCTCC ACGAGGCCCT GGGTCACTTT AGGCGCGGGG CGCTGGCGGC 102960

GGTTCAGCTG TTGTTTCCCG CGGCCCGCGT AGACCCCGAC GCCTATCCCT GTTATTTTTT 103020 CAAAAGCGCC TGTCGGCCCC GCGCGCCGCC CGTCTGTGCG GGCGACGGGC CCTCGGCCGG 103080

TGGCGACGAC GGCGACGGGG ACTGGTTCCC CGACGCCGGT GGCGACGACG GCGACGAGGA 103140

GTGGGAGGAG GACACGGACC CCATGGACAC GACCCACGGC CCCCTCCCGG ACGACGAGGC 103200

CGCGTACCTC GACCTGCTAC ACGAACAGAT ACCAGCGGCG ACGCCCAGCG AACCGGACTC 103260

CGTCGTGTGT TCCTGCGCCG ACAAGATCGG GCTGCGCGTG TGCCTACCGG TCCCCGCCCC 103320 GTACGTTGTG CACGGCTCCC TGACGATGCG TGGGGTGGCG AGGGTGATCC AGCAGGCGGT 103380

GCTGTTGGAC CGCGACTTCG TGGAGGCCGT AGGGAGCCAC GTAAAGAACT TTTTGCTGAT 103440

CGATACGGGC GTGTACGCCC ACGGCCACAG CCTGCGCTTG CCGTATTTCG CCAAGATCGG 103500

CCCCGACGGC TCCGCGTGCG GCCGGTTATT GCCCGTCTTC GTGATCCCCC CCGCGTGCGA 103560

GGACGTTCCG GCGTTCGTCG CCGCGCACGC CGACCCGCGG CGCTTCCACT TTCACGCCCC 103620 GCCCATGTTT TCCGCGGCCC CGCGGGAGAT CCGCGTCCTC CACAGCCTGG GCGGGGACTA 103680

TGTCAGCTTT TTCGAGAAGA AGGCGTCGCG CAACGCCCTG GAGCACTTTG GGCGACGCGA 103740

GACCCTGACG GAGGTTCTGG GCCGCTACGA TGTGCGGCCC GACGCCGGGG AGACCGTGGA 103800

GGGGTTCGCG TCAGAACTGC TGGGGCGAAT AGTCGCGTGC ATCGAGGCCC ACTTTCCCGA 103860

GCACGCGCGG GAATATCAGG CCGTGTCCGT TCGCCGGGCC GTCATTAAGG ACGACTGGGT 103920 CCTGCTGCAG CTGATCCCCG GCCGCGGCGC CCTGAACCAA AGCCTCTCGT GTCTGCGCTT 103980

CAAGCACGGC AGGGCAAGTC GCGCGACGGC CCGGACCTTT CTCGCGCTGA GCGTCGGGAC 104040

CAACAACCGC CTATGCGCGT CCCTGTGTCA GCAGTGCTTT GCCACTAAAT GCGATAACAA 104100

CCGCCTGCAC ACGCTGTTTA CCGTCGATGC GGGCACGCCA TGCTCGCGGT CCGCTCCCTC 104160

CAGCACCTCA CGACCGTCAT CTTCATAACG GCCTACGGCC TCGTGCTCGC GTGGTACATC 104220 GTCTTTGGTG CCAGTCCGCT CCACCGATGT ATTTACGCGG TGCGCCCCGC CGGGGCACAC 104280

AACGATACCG CCCTCGTGTG GATGAAGATA AACCAGACGC TGTTGTTTCT GGGCCCGCCG 104340

ACCGCCCCCC CCGGCGGGGC ATGGACCCCC CACGCCCACG TCTGCTACGC CAATATCATC 104400

GAAGGTCGGG CCGTGTCCCT CCCGGCCATC CCCGGCGCCA TGAGCCGCCG GGTCATGAAC 104460 GTGCACGAGG CCGTAAACTG CTTGGAGGCC CTCTGGGACA CCCAGATGCG CCTGGTGGTC 104520

GTCGGTTGGT TTCTGTATCT AGCGTTCGTC GCCCTTCACC AACGACGATG CATGTTCGGC 104580

GTCGTGAGTC CCGCGCACAG CATGGTGGCC CCGGCGACCT ATCTTTTGAA CTACGCCGGC 104640

CGCATAGTGT CGAGCGTGTT CTTGCAATAC CCCTACACGA AAATCACCCG CCTCCTCTGC 104700 GAGCTATCCG TTCAACGCCA GACCCTGGTG CAGCTGTTCG AGGCGGATCC GGTCACCTTC 104760

TTGTACCACC GCCCGGCCGT TGGCGTCATC GTGGGCTGCG AGCTGCTGCT CCGCTTCGTG 104820

GCCCTCGGTC TCATCGTCGG CACCGCTCTC ATCTCCCGGG GCGCCTGCGC GATCACATAC 104880

CCCCTGTTTC TAACAATCAC CACCTGGTGT TTCGTGTCCA TCATCGCCCT GACGGAGCTG 104940

TATTTCATCC TGCGGCGGGA CTCGGCCCCC AAAAACGCGG AACCAGCGGC CCCCAGGGGG 105000 CGCTCCAAAG GGTGGTCGGG CGTCTGCGGG CGCTGCTGTT CCATCATCCT CTCCGGT TC 105060

GCCGTGCGCC TGTGCTATAT CGCCGTCGTG GCCGGGGTGG TGCTTATGGC GCTTCGCTAC 105120

GAACAGGAGA TTCAGCGGCG CCTGTTTGAT CTGTGACGTA ACGCCTCTTC CGTTGGAAGA 105180

GGCGGACCCA GTCGCCCATG CAAATTAAAT ACACGACCCG CCTCGGGCCT ACGCACCCTC 105240

GCACGTCGCA TGCAAATTAA AATCGTGCAC AGAGCCGATC CGGCCTCGGG TCTGCTTGCC 105300 CCTCCCCCGG TCCAGCACAG GCAGGCTCGT CCGACTTCCG CATACACCCC ACCCTACCGC 105360

GTGCTTCCGC ACCCCCGCCT ACGCGTGTAC GCGAAGGCGG ACCCAGACCT GCCGTATGCT 105420

AATTAAATAC ATAAAACCCA CCCTCGGCGT CCGATTGGTT TCTGGGGACG GCGGGGGCGG 105480

GGGCGGTGAC GCCCGACGGG GAGGGACAAG GAGGAGTTTC GGAAAGCCGG CCCCGGTCGT 105540

GCGGGTATAA GGGCAGCCAC CGGCCCACTG GGCGCTGTGT GCTGCCGTGT GCCGACCCCG 105600 GTTGCGCGTC GGTGCCGCTC CTCGATTCGG ACCCGGCCAC TCTCTTCCGA CACGCGCCCC 105660

CTCGGAGGAC ACCCGCCATC CCAGCCCCGG CGACCTACAA CATGGCTACC GACATTGATA 105720

TGCTAATCGA CCTAGGATTG GACCTGTCCG ACAGCGAGCT CGAGGAGGAC GCTCTGGAGC 105780

GGGACGAGGA GGGCCGCCGC GACGACCCCG AGTCCGACAG CAGCGGGGAG TGTTCCTCGT 105840

CGGACGAGGA CATGGAAGAC CCCTGCGGAG ACGGAGGGGC GGAGGCCATC GACGCGGCGA 105900 TTCCCAAAGG TCCCCCGGCC CGCCCCGAGG ACGCCGGCAC CCCCGAAGCC TCGACGCCTC 105960

GCCCGGCAGC GCGGCGGGGA GCCGACGATC CGCCACCCGC GACCACCGGC GTGTGGTCGC 106020

GCCTCGGGAC CAGGCGGTCG GCTTCCCCCC GGGAACCGCA CGGGGGGAAG GTGGCCCGCA 106080

TCCAACCCCC GTCGACCAAG GCACCGCATC CCCGAGGCGG GCGGCGAGGT CGCCGCCGGG 106140

GCCGGGGTCG ATACGGCCCC GGCGGCGCCG ACTCCACACC AAACCCCCGC CGGCGCGTCT 106200 CCAGAAACGC CCACAACCAA GGGGGTCGCC ACCCCGCGTC GGCGCGGACG GACGGCCCCG 106260

GCGCCACCCA CGGCGAGGCG CGGCGCGGAG GGGAGCAGCT CGACGTCTCC GGGGGCCCGC 106320

GGCCACGAGG CACGCGCCAG GCCCCCCCTC CGCTGATGGC GCTGTCCCTG ACCCCCCCGC 106380

ACGCGGACGG CCGCGCCCCG GTCCCGGAGC GAAAGGCGCC CTCTGCCGAC ACCATCGACC 106440

CCGCCGTTCG GGCGGTTCTG CGATCCATAT CCGAGCGCGC GGCGGTCGAG CGCATCAGCG 106500 AAAGCTTTGG ACGCAGTGCC CTGGTCATGC AAGACCCCTT TGGCGGGATG CCGTTTCCCG 106560

CCGCGAACAG CCCCTGGGCT CCCGTGCTGG CCACCCAAGC GGGGGGGTTT GACGCCGAGA 106620

CCCGTCGGGT TTCCTGGGAA ACCCTGGTCG CTCACGGCCC GAGCCTCTAC CGCACATTCG 106680

CAGCCAACCC GCGGGCCGCG TCGACAGCCA AGGCCATGCG CGACTGCGTG CTGCGCCAGG 106740

AAAATCTCAT CGAGGCCCTG GCGTCCGCGG ATGAGACGCT GGCGTGGTGC AAGATGTGCA 106800 TTCACCACAA TCTGCCGCTC CGCCCCCAGG ACCCTATCAT CGGAACGGCG GCCGCCGTGC 106860

TGGAAAACCT CGCCACGCGC CTGCGCCCCT TTCTGCAGTG CTACCTGAAG GCCCGAGGCC 106920

TGTGCGGGCT GGACGACCTG TGCTCGCGGC GACGCCTGTC GGACATTAAG GATATTGCCT 106980

CCTTTGTGTT GGTCATCCTG GCCCGCCTCG CCAACCGCGT CGAGCGCGGC GTGTCGGAGA 107040 TCGACTACAC GACCGTGGGG GTTGGGGCCG GCGAGACGAT GCACTTTTAC ATCCCGGGGG 107100

CCTGCATGGC GGGTCTCATT GAAATACTGG ACACGCACCG CCAGGAGTGT TCCAGTCGCG 107160

TGTGCGAGCT GACGGCCAGT CACACTATCG CCCCCTTATA TGTGCACGGC AAATACTTCT 107220

ACTGCAACTC CCTATTTTAG GCAAGAATAA ACATATTGAC GTCAACCCAA GTGGTTCCGT 107280 GTGATGTTCT TGGCGCGCGC GGCGGGTGGG GCGGAGACTC CGGGGCGATG CCGGCGTGCG 107340

CGTGGGAGGA GGGCGATGAC CCACCGGATA AATGTGGGGC CCCGGCCCGG CCCGCTTCAT 107400

AGCGCGTCCA GGAACTCACG GCAGACGCGT ATTCACCGAC CCCCCCCCTC GCAACATGAC 107460

AACGACGCCC CTCTCGAACC TGTTTTTACG GGCCCCGGAC ATCACCCACG TCGCCCCCCC 107520

GTACTGTCTG AATGCCACGT GGCAGGCCGA AAACGCCCTG CACACGACCA AAACGGACCC 107580 CGCGTGCCTG GCCGCGCGGA GTTATTTAGT CCGCGCCTCC TGCTCGACCA GCGGCCCCAT 107640

CCACTGTTTT TTCTTTGCGG TGTACAAGGA CTCGCAGCAC TCCCTTCCGC TGGTTACCGA 107700

GCTCCGCAAC TTCGCGGACC TGGTCAACCA CCCGCCCGTC TTGCGCGAAC TAGAGGATAA 107760

GCGTGGGGGG CGGCTGCGGT GCACGGGCCC ATTCAGCTGC GGAACCATCA AGGACGTCTC 107820

CGGTGCATCC CCCGCGGGGG AATACACGAT AAACGGTATC GTGTACCACT GTCACTGTCG 107880 GTATCCGTTC TCCAAAACCT GCTGGCTCGG GGCATCCGCG GCCCTACAAC ACCTTCGCTC 107940

TATAAGCTCA AGCGGCACGG CCGCTCGCGC GGCAGAACAG CGACGCCACA AAATCAAAAT 108000

CAAAATCAAG GTATAACCCA CCCCCTTCCC TCCGAGTCCG TATGCAACCT CATTAATAAA 108060

GAGTGAGAAC CAACCAAAAC AGACGCGGTG TGAGTTTGTG GGTTATAGGA ACCCGGTAAA 108120

TACCACGCGA CGAACCAGCG TGTGTGTTAA CGCGACTTTT ATTCGTTGTA TCGCGGGAGG 108180 GGGGAAGCTT ACCGCCAAAG GAAGGCCAAG ATGATAACGA CGACCACCGC GACCACCCCA 108240

AAAACCGCAT GACGACACGT CCCGCCACAC CACCCTGGGG CTTGGGGCGT GTCGGAGCTC 108300

GACGCACAGC GGGCCGCGCG TTGGGCCCGG TACAGCTCTC GCGAATTGAC GAGCGGGGGT 108360

CGCCACGTGC GCGAGCTTTG CACGCGGGGT TGGTCGGCCG GCCCCACGGA CCCGCCCGGT 108420

GGCTCGGTCG GACATGCGGC CATGACCATG GCGTAGGTGG GGGGGCGATC CGAGGTCGCC 108480 TCTGCGTAAG TAGGGAGGCC CGACGGGAGG TCGCCTCCCA CGCCAGGGTG GGCCCCAATC 108540

ATAGTTTCCG GTAGAAACAG GGGGGTCTCC ACAAACAACC CCCCTGGGCC AAAGCTCCGG 108600

CGCCGCGCCC GTCGTTCGGC GCGGCGCCTG GCGCGCCGAG CGGCCCGCCA GGCGGCGCGG 108660

CGCGAGCGGC CACGCTCACA CACCTCGCCG TCACCGGAAG AAGCCGGTGA AACAAGCCCA 108720

ACCGGCGACG TCCCTGCAGA GTACGGTGGA GGCGAGTCCG TGGGGGTGTC GATATCAATA 108780 ACGACAAACT GGCCCGCGCT CGCGCCGGCC ACACTCTCGT ATGGGGGCGG GGCGTCAATC 108840

ACGCTATCAT CTCCGTCATC CCTGCATGCG TGGGCATGCC CAGCCCCCAA CGCCATGGTG 108900

GGGATTCGCG GCTCAGAAGC CTGCATGTCG TGTGGTCGGT CGTAGTCCAA CGTGCCTCCC 108960

CCACCCACCA CACAGCCGGT CCCCACGCCG ACCACTAGAC CGCAGACGTC GCCCAACCGA 109020

GGTCCCCGTG CACAGACCGC GCCTTTTATA GCCCCAGGGG TTGCTAATTA ACGCACGCAT 109080 GCAGACGCAA TTTATTTTGC TCCCCCGCGT CCTCCCCTCC CCCGCGTCCT CCCCTCCCCG 109140

TCCTCCCCTC CCCCGCGTCC TCCCCTCCCC CGCGTCCTCC CCTCCCCTGC GCACACGTGA 109200

TAGGTCTTGG GAACCCGAGG GGCGACGCGG GGAAAGCGCG CCCCCGCCCG GCCGCCGCGC 109260

GCCCCCGCCC GGCCGCCGCG CGCCCCCGCC CGGCCGCGCG CCCCCGCCCG GCCGCCGCGC 109320

GCCCCCGCCC GGCCGCCGCG CGCCCCCGCC CGGCCGCCGC GCGCCCCCGC CCGGCCGCCC 109380 GCGTCGCGCC GGCGCCCCCT CCCGGCGCTT CCGGGGCCTT TCCTTCCTTC CCCGCCGCGA 109440

CCCCGGCCCC GCCCCACCGC CCCGCCCGGC AGGGGGGCCC CGGCGCCGCG CAGAACACAC 109500

AGACGAACAC ACGGTGGCGA TCTTTTCTTT ACTTCGGCAG ACCAGCGAGC CCCGGCCCCG 109560

GCCCGCGCCC CGCCGCCACA CCCACGGCAC CCCCCCCGCC GCCCACCCCG GGGTCCACAC 109620 AGGAGCGCGC GGGCGGCAGA AACGCGGGCG CGGCGGCGGT CGGGGTGGGA GTGGTGGTGG 109680

GGGACACGAA AACACACCCA CGACACTCTC CCCCCACCCC GACCGCCGCC GCGCCCCACC 109740

GGCGGGATCG CGGCGAGACG CAGCCGGGCC CCCCCCCACC ACCCGCCCAC CCACCTACCC 109800

CGCGCCCGCA GCCTCCGGCA GCACGCCGAC CACCGCCGCC ACCCCCCAAA CAGCCAAGGC 109860 GCGGTGGGGG GCGTGGTGGT GAACGATGGG GGGAACACGG GGGGGAGGGG TCCGGGGCGA 109920

GGCGGGCGGG CGAAGGAAGG GGGGGTGGTG GCGGCGGCGG TGGAAAGCGG AAAAACGGAG 109980

GATGGAAGGG CAGAAGATGG GGAGTCCCGA TCCTCCTCCT GCATCCCCTC GCCTTCCATT 110040

CTCCGGCCCT CCGCGAGTCC CGACGCCCCC CCCCCGCCGC CCGACGAAGG AGACCCAAGC 110100

ACCGCAGCCG GAGAGGCCGA GCGGGGAGTG GGCGGCCGGG CGGGAGGATG GCGGAGAGAG 110160 AGAGAGAGAG AGAGAGAGGG GGGGGGGGGG AGAGGGAAAG CAACGGGAAA GAGAGGCGCG 110220

CGGAAAAGCA GCAAGAGGGG GGACGGGGCG AGCCGGGCAG AGTGCGGAGC CCCCGGAGCC 110280

CGCGGCCGCA GCCGAGCAGC GCCGCGGGCT CCGGGGCCGG GCCGGGCCGG CAACGCCCCG 110340

CGCCGGCCGC GGCGGAGAGA ACCCCTGTGT CATTGTTTAC GTGGCCGCGG GCCAGCAGAC 110400

GGGCCGCGGG CCAGCAGACG GGCCGCGGCG CCAGCGGCCC ACGCCTCCCG CCGCATTAGG 110460 CCCCCGCGGG CATCCGGCGG CCGGCCCCAC GCCCTTCCAT TAAACACTCC CACGTTGGGG 110520

GGGGGCGCGC CAGCTGAGTG CTCTGCGGTT GCGGGCGCCG TGCCCGGAGA TCCATTAAGC 110580

CGCCGGAGAG CCCGAGCCCC GCCCGCGTGT TGCTGTGGGC ATTTCTGCTG CGTCATCCCT 110640

GTCTTTATAA AACCGGGGGC GCGGCAGCAA CGAACACAGG GGCCCGCCGC CGATCGAGAG 110700

GGACTCCGGA GAAGGAAGGC TGCTCCGCGC ACCGGCGCGC CCTTCTCCTC TCCCCTCCCT 110760 ACCTCCCCCT CTCTTCCCCC TTTTTTCCCC CGCCTCCCGT CTTCTTCCGC GCCTCCGAGG 110820

GTCCGCCTCT GCCTCGGGGA CCCCCGGGCG GGCCGGGGCT TGGCCGCCGA GGTGCGCCCC 110880

GGCCGGAGGG GCCCCCGCAC CTCGGCGGCC GCCCCCTCCG GCGCCGCGCG TTCGCGAAAG 110940

GCGCGAAAGG GGCCCCCGGA GGCTTTTTTC GATTCCCGGC CGGGGGTCCC GGGTAGCCGC 111000

CCGGCGCCGG TCGGAAGGCG TCCCCCGCCC GGCGGTCNGG NNNNGGCCCC CGGCGGAGCG 111060 CGGGGGCCCC GGGGCCCCGG GCCGCGCCGG CGGCGTTTCC GCGTTCCGTT TCTTCTCCCT 111120

CCCGGCCGCC CCGCTCCCGG GCCCGACCCT CGCCCCTTCC CTTCTCCTCG TCTTCCCCCG 111180

TCCCGCCGCG CCCCTTCCCT CTTCCTTCTC TCTCTCTGTC TCGCTGTCTC GCTCTCCTCA 111240

CATTTCCCCC CCCCCCCCCC GGCCGCCGCC GCCGCCCTCT GCCCGCGTCC CACCGAGACG 111300

CCGCGCCGCG TGAGCCGTCC GCCGGGGGAC CCAGGCTCCG GGGGGGGGGC GCGCCTGCGT 111360 GTGTCTCGTG TGAGAGAGCG CGCCCCTCGA ACGCCGCGCG TTCTCGCAGG TAGGTTTAGG 111420

GTCGTACAGG TGAGCTTCTG CTGAGGCGGC GGGAGAGGGG GGGGCGGGCG GAAGAGAGAA 111480

GAGAGCAGGG GTTGGGGGAA AACTGTTCTT CCTCCCCCTT TCAAGAAACA CGAGGCGGGG 111540

GTCCCAGAAA GGGCAGGCAG GTCAGCCGCA CCGCCCGCGA GCCAACCCGT ATCCTTTTTT 111600

TCTAGGTGTT TTTGTTTTTG TTTCTGTTTT TGTTTGTTTT GTTATTATTT TCGCGGATCC 111660 GGCGTGTTCG GATCCACCCC CCCCTTTCTC CTTCCTCTTC CCTTCCACCC ACCCCCGTTT 111720

CCCCCCCCCC CCCGTGGTGT CGTCCGGGGG CGTCGTTCCC AGGGGGGGCA GGCGCGGGTC 111780

GGGCCCATAC GCCCACCGCC CCCACGCGCC GGTCACCCCC CCCCCAACAA CCCCAAAGGC 111840

GCGTGCCCGG CCACAGCCGT GGGTGTGGCG CCCGTCCCCT TCCTCTACCG CGTGGGCGCG 111900

GGCGGGGGGG TGGTGGTGGT AGTGGTGGCG GAAGGAAACG GGCCGGGGGG CCGGGGCCGC 111960 TAGGGAAAGG TAGGCACGCG CGCGGTGTGT CGACTTGCAT GCCCCGCAAA ACGCGTCGTG 112020

TCGTGTTGTG TCGTGGTGGG CCGTGTTGTG GTGGGCCGTG TGGTGTGGTG TGGTGTTGCG 112080

AACGCGCGAG CCCCCTCGCC CCGATGGGAG TCTCCCCGCA GCCAGGGTAA GGAGGGGCGG 112140

GCGTGGCGGG CAGGTGTGCG GGCGGGGTGG GGTGAGTGCG GTTGCATGCC TCGGGTCTCC 112200 TCTTCCTGCT CCTCCTCCTT TCTCCCAGCC AGGGTGAGGA GGGGCGGGCG TGGCGGGCGG 112260

GTGTGCGGGC GGGGTGGGCG CCGGGGCGGG GGTGGGCACG GGCGTAAGTG CGGGTGCATG 112320

CCTCGGGTCT TCTCTTCTCC CTCCTCCTTC CTCCCACCCG TCCCCGGGGG CAGAGGGCGT 112380

GCATGCGTTG TGATTCAACC GCCCTCGCCC CCGCCCCACT TTCCCCCCTC TCTATCAAAG 112440 TTCCCTGGCC CCTGGCTTCG CGCCGGTGGT GCGGCTGACC CCCCCCTCCT CCCTCCCCGA 112500

GCCAGGCGCC CTCCCACTCC TGCCCACCAC CCCCCGGGTC TGGCCGGCCA GACGTGCGTG 112560

CTCTGCACGA TCGGGCCCCC CTCCCTGTCA ACACGGACAC ACTCTTTTTT TACCCGCCAG 112620

CCCGCCCACC CACCAAGACA GGGAGCCAGA ACGCAGGCCG GGCCCCGGCT CTGTTCTATG 112680

ATAAAGACCA ACAGGCCTCG GGGGTGGGGG CGGCTTCTCG TGCCCGCCAA GGAGACGCCC 112740 GCCCCGACCA CCCTCGCAGC GCAGGCGCAG GCCGCGACCC CTCTCTGCTC TTTGGAGGGA 112800

GCCGGGGGCG CGACGACGCG GCGCCCCCGG CTCCTTCACA CGGTCCTTCT GCGCGGTGCG 112860

CCTCCCGCCG GGGCTCGGGC CCCGGGCGCT GGGCCGCGGG CCGGAGTGCG CGATGGACGG 112920

GTAGCGCCCC CAGAGCTCGC AGCACCGGGA CCGCGGAATG CACTTGTTCT GCCAGTGCCC 112980

CCTGACGGAC GGGCAGGACC TGTACCTCTG CCCGGTGTAT CCCCGGATGC ACCAGGAGCA 113040 CCTGGTCTGC CCCTTGCACC GCCTGGACGA CGCCCGGCGC CGGGGGCGCA CCTCGGCGGC 113100

GTGGGACGAG GGGCTCGTGC GCGCGTTGAC GCACTCCGGG GGGCTGATGG GCTGCGGGGG 113160

GCGCAGCCTC ACCTTGTCGG AGACCTACTG GGGCCACCCG TTGTACGAGA AACTGGTCCC 113220

GTGGGACCAC CCGCGCGACC TGAAGGTGCC GGAGGCCAGC GCGGTGGGCA CCAGAGCCCT 113280

CGTCCCGCGC GGGCGCGGCC GGCCGCTGCG GGGGCGCCCG GTGCCCCTCA TCCCCCTCGA 113340 TTGTGAGCCG AACGACGGGC TTCCCTTCGG CGGGGGGTGG CCTGGTGGCC GGCTCCGCGG 113400

AGCCCCCGTC CCCCTCCACC CCCCCCCCCC TTCTGCCCCT CCTCTGTCCT TCACCCCCAC 113460

CCTCACCCCC CCCTGCCTGT GCCGGGGCTT GTCGTTGTGT GTGGTCGTAA AACAATACCT 113520

GAAAGACCGG AACAACTTTT GAACTCCTTT TTTTTGAAAT ATAAATATTT TTAAAATGTT 113580

ATTTCAAAAC ACTACGAAAA CTGTGTGAAA CAACAACCGG AAACTACGTC GAGGGGGCGC 113640 GTCCCCCCGG CCCCTACGCC CCCCCCTTTC CCTCCTCCTC CTCCCCGCCC TCCGCCTCCT 113700

CCTCCTCCGC CTCCTCCTCC TCCGCCTCCT CCTCCTCCGC CTCCTCCTCC TCCGCCTCCT 113760

CCTCCTCCGC CTCCTCCTCC TCCGCCTCCT CCTCCTCCGC CGCCGCTGGC GCCGGACCCT 113820

GCTGCCTCTG CGGCTGCCCC CGCGCCGCGG GCGCCTGCGG CCCCGCTCGC CGGGCACCGG 113880

CGCCAGCGGG CTCAGGCTCA GGCCCCGGGC CGCGCCGCGG CGGGAGAACC GGGGGTGGGG 113940 GACCCCCCGC TCCCCGCTCG CGCCCCGCCG CCTCCTTCTC CGCCTCCTGC TCCGGCGCCC 114000

CGGGCTCAGG CTGGGCGCGG AGAAGGCCCC CGCCCGGAGA GGAGGAGGCG CGTCCACAGG 114060

AGCCCGGGGC CCCCCCCTCC AGACGGTGTC AGCAGCCCCG CGCGCCGCGC GGGGGCGCGC 114120

CGGCAGCGGG GCGCGCAGGC CTCAGGCGGG GCGCGGCGGC GGCGGGGGCA CCACAGACGC 114180

TCGCGCCTGC GCCGGCCCGG GCGCGGCGGG CGGCACGGCC ACCTGCGCGT GGCGCGCGGG 114240 GCCAGCGCGT ACTGGGTCCG AGTCTGGCTG TGGGTTCGTG TCTCAGACCC GGCCCGTCCG 114300

CGCTGGCTGC GCGCGCCCAG CCCTCCCGGC CCGCGCCTCC CTCCTGGGCC CCAGGGGGCG 114360

CCGTGGTTGT GGGGGCCACG GCGGGGGGTG CGGCGCCTCC CCCGCCGTCT GTTTCCTCTC 114420

GCCGGGCCCC GGGCGCCCCG CCGCGCCTCT GCCGCCCCCT CTCAGCGACT ACTGATACCC 114480

CCCGAGGACC CGGCGCGCCC CGACAGAGCG CCCCCCGCAG GACGGGAGGC GGCGGCGCCG 114540 CAGAAGCGGG TGGGCGGCGC GGACGCGCGC GGGGGGCGGC CGGCGTCCCC CTTCTCTCCG 114600

GTGAGAGCCG TGCTGCCGGC GCTGCCGTCC CGGCGGGGGT ATGCGGTTCG CGCGTTAATT 114660

GGGAGTGATT TCCCTTGTTT TCGACCTCGA GGTGGCGCCA CCGCCGGCGA GATCTTGATC 114720

ACCTAGGGGG CCCGACGTCC TTAAGCTACT GGGTCTAGGG TGGGGGCGGG CGTTGCCCCG 114780 CGGCGGCGAC GACGACGAGG CGCCCCGCGG TCCCCCGCGG CCAGCCCAGC GCCGCCCGAC 114840

CCTCCAAGGC GCCCAGCGGG GGCGTGGCGG CGGGGGCGCG GCCCCGCGAG AAGCCCCCCG 114900

CCCGCCCTGC ATCAGGCGAC GTCTCCCTCT GTCTCTGCCC TTGGGGGCCA ATCACGGGCT 114960

GGGGGCGGGC TGGGGGCGGG TCACGGGCTG GGGGCGGGTC ACGGGCTGGG GGCGGGTCAC 115020 GGGCTGGGGG CGGGTCACGG GCTGGGGGCG GGCGGGAGTG GCAGCCGGTC CAGTAGCAGG 115080

AGCAGCAGGC ACGGCCCGGT GCCCCCCCAC CCGCTGTCCC GCGCCTGGCA CACAGGGGGG 115140

TCGCTGTCCC TCGCGCCCCG GCAGGCGCCC AACGGGCAGG TCTATTTCAG GTGCCGGCAC 115200

GGCCTGGCGT GCCGGCGGAG CCGGAGGTGC GCCCAGGCCC CCAGCAAGTG ATAGCCCTAC 115260

CACGACTTGC TGGGCGACCG CCAGTGCGGG TGATAGTCCA TGCGGTGGCC CCACAACGTG 115320 TCCCCTGTGC ACAACGCGTT GCCTTAGGTC CAGAAGTACG TGCCCTACGT CTTCCCCACG 115380

TCCGTCCCTT TTGAGACCGT CGCGTCCCCG CCCCGCTAGA GCAGGCACGT GTGCCGTGTG 115440

TGCAGCGGGG GGGGAGGGCG AAGGCGAAGG AGGAGTGGGT GCCCGGGTGG GGGCGTCCTA 115500

GGGACGCGCA GCCGCCCGCA CCCCGACGGG ACCGCGAGCC GGCCCCCGGC CCGGCCCCCG 115560

CACCGGCGCA GGTAGTCCGG GCGGAGCTTG TAGAGGCACA GGCACGACGG GCGGAGCCTC 115620 CACCTCAGCG CCACTTCCAG CAGCAGTCTC TAAGGGTGGA GCCAGAGGAG GAGGCTCAGC 115680

GACGACCGCT CGGTGACGTA CAGCAACTCG TAGGGGGTCC GCACGCCCCG CCGCCCGACG 115740

AACTGTTTCT TTGCCCCCCC CTAAATCTCC CGCGCCCCGC ACTCCGCCCT GGGGGCACGG 115800

CACAGGGGGC ACAGGGAGGG AGTGGGGCCG GGGGGCGGGC GACGAAAAAC AAGCCTTCCC 115860

CCCCTCTTTC CCCAGGCATT GGTTTCCACC AGACGCAGGA AACCTAAGGC TGGGGAGCAG 115920 AGGGGGGGGG ACAGGGGGCG AGAGCCCGAG TCCCGAGGGA CGGAGGGAGC GGGGGGGTTT 115980

CCCAGCCCCC CGCCGCGTGC CGGGTGCCCC CAGGGGGCTG GCGAATTCGC CCGGCCCCCA 116040

GCCGGGGCAG TTCGCAGGGG CGGGGGCTCG GGTGGCGGGC GCTGGTGGGG GTTGGGCGTC 116100

GGCCCACCAG GCCCCTTTTC CCCCCCGGAC TCTGGGCCCC CAGCGGGAGA GTGGCACGGC 116160

CCCCAGACGG CGCCGCCGGC GAGCCCCGGC CCCAGGCGGG CCCTCGAGCA CGGCCCGGCC 116220 CCAAGGTACT CGGCCCCATC CCATCTGAGC TCTGCCGCCG GGCGCCAGAG AGAGAACGGC 116280

CCACAATCAG AGACAGAGAG GCCCAGAGGA GGAGGGCGGC CCGGCGGCGA GGCAGCGAGC 116340

GTCACGGCCC CACGCTTACG CCGGGCTGGC AGTGTGCCCC GACGGAATAT GGGCCGCGGA 116400

TAGGTGAGGG GGTTTCCCCG CCGTAAATGC TAAGGGGGTT ATCGGCGCGC GGGGCCGCCC 116460

CCGCCTCCCT CCCTTAGGGG GGGAGAGCCC CGCCGGGGCA GGGGCCCCTG GTTGGCCCAC 116520 ATGAGGTTCT TGGGGTAATC GTACGCGGCG GGGGGCGGCT GCGTCTACCC TCAGGGGGGC 116580

CGCGGGGCGG CCGCGCCGGG ACTCACCACG GGCGGGGGCC CCTCTTTAAG TAATCGTATG 116640

ATCCTTCGGG TCCCCTGGTT ATCCCCGGCT AGTCGGGTGG GTGGGCCGCC GCGCGCTCCG 116700

AGACGCACAA GACGGTTCTT TCATTAGTCG TATTGGGCCT TGGGGCTCCC TCATTAATGC 116760

GCCCCTCGCT CCCCGGCAGG CTTGCAAAAA TTAATGGTAT TCGCCCTTAC CGCCGGGCAA 116820 TTTTCGACGA TTAATGGCGC TCGCCCTTGC GGCCGGGTAA TTTTCAACGA TTAATGGTAC 116880

TCGCCCCTAC CGCCGGCCCT GGCGGATAAT TTTCAAAGAT TAATGGTATG GCCCTTCGGC 116940

CGCGCCCCGC CAGCGGCCCC GCCTCAGGCC CGGGCGCGCC GCCGCGCGCC AACCGGCCGC 117000

GGCGGGGGAC CCCGCCCGCC TCGCCGCCCC GCCGCGGCCC GGGAGCGCCT ATATATGCGC 117060

CCCGAGGGTA GCAGAGAAGC CTCTCGCCGG AGCGCGTCTG GAAGCCTCGA GGCCCCGAGG 117120 CGGCCGGCTC CGGCGGGAGC GGCCAAGTTG GGATCTGGCG GGCTGCCGGG CCCGGGCGCC 117180

GCCGCCTCCT GGGCGCGCGG CGGCGGCGGC GGA 117213

(2) INFORMATION FOR SEQ ID NO: 218: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 180 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 218:

Met Arg Thr Pro Ala Asp Asp Val Ser Trp Arg Tyr Glu Ala Pro Ser

1 5 10 15

Val Ile Asp Tyr Ala Arg Ile Asp Gly Ile Phe Leu Arg Tyr His Cys 20 25 30

Pro Gly Leu Asp Thr Phe Leu Trp Asp Arg His Ala Gin Arg Ala Tyr

35 40 45

Leu Val Asn Pro Phe Leu Phe Ala Ala Gly Phe Leu Glu Asp Leu Ser 50 55 60 His Ser Val Phe Pro Ala Asp Thr Gin Glu Thr Thr Thr Arg Arg Ala 65 70 75 80

Leu Tyr Lys Glu Ile Arg Asp Ala Leu Gly Ser Arg Lys Gin Ala Val

85 90 95

Ser His Ala Pro Val Arg Ala Gly Cys Val Asn Phe Asp Tyr Ser Arg 100 105 110

Thr Arg Arg Cys Val Gly Arg Arg Asp Leu Arg Pro Ala Asn Thr Thr

115 120 125

Ser Thr Trp Glu Pro Pro Val Ser Ser Asp Asp Glu Ala Ser Ser Gin

130 135 140 Ser Lys Pro Leu Ala Thr Gin Pro Pro Val Leu Ala Leu Ser Asn Ala

145 150 155 160

Pro Pro Arg Arg Val Ser Pro Thr Arg Gly Arg Arg Arg His Thr Arg

165 170 175

Leu Arg Arg Asn 180

(2) INFORMATION FOR SEQ ID NO: 219:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 334 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 219:

Met Lys Arg Ala Arg Ser Arg Ser Pro Ser Pro Pro Ser Arg Pro Ser

1 5 10 15

Ser Pro Phe Arg Thr Pro Pro His Gly Gly Ser Pro Arg Arg Glu Val 20 25 30 Gly Ala Gly Ile Leu Ala Ser Asp Ala Thr Ser His Val Cys Ile Ala 35 40 45

Ser His Pro Gly Ser Gly Ala Gly Tyr Pro Thr Arg Leu Ala Ala Gly

50 55 60

Ser Ala Val Gin Arg Arg Arg Pro Arg Gly Cys Pro Pro Gly Val Met 65 70 75 80

Phe Ser Ala Ser Thr Thr Pro Glu Gin Pro Leu Gly Leu Ser Gly Asp

85 90 95

Ala Thr Pro Pro Leu Pro Thr Ser Val Pro Leu Asp Trp Ala Ala Phe 100 105 110 Arg Arg Ala Phe Leu Ile Asp Asp Ala Trp Arg Pro Leu Leu Glu Pro 115 120 125

Glu Leu Ala Asn Pro Leu Thr Ala Arg Leu Leu Ala Glu Tyr Asp Arg

130 135 140

Arg Cys Gin Thr Glu Glu Val Leu Pro Pro Arg Glu Asp Val Phe Ser 145 150 155 160

Trp Thr Arg Tyr Cys Thr Pro Asp Asp Val Arg Val Val Ile Ile Gly

165 170 175

Gin Asp Pro Tyr His His Pro Gly Gin Ala His Gly Leu Ala Phe Ser 180 185 190 Val Arg Ala Asp Val Pro Val Pro Pro Ser Leu Arg Asn Val Leu Ala 195 200 205

Ala Val Lys Asn Cys Tyr Pro Asp Ala Arg Met Ser Gly Arg Gly Cys

210 215 220

Leu Glu Lys Trp Ala Arg Asp Gly Val Leu Leu Leu Asn Thr Thr Leu 225 230 235 240

Thr Val Lys Arg Gly Ala Ala Ala Ser His Ser Lys Leu Gly Trp Asp

245 250 255

Arg Phe Val Gly Gly Val Val Arg Arg Leu Ala Ala Arg Arg Pro Gly 260 265 270 Leu Val Phe Met Leu Trp Gly Ala His Ala Gin Asn Ala Ile Arg Pro 275 280 285

Asp Pro Arg Gin His Tyr Val Leu Lys Phe Ser His Pro Ser Pro Leu 290 295 300 Ser Lys Val Pro Phe Gly Thr Cys Gin His Phe Leu Ala Ala Asn Arg 305 310 315 320

Tyr Leu Glu Thr Arg Asp Ile Met Pro Ile Asp Trp Ser Val 325 330

(2) INFORMATION FOR SEQ ID NO: 220:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 231 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:220:

Met Val Lys Ser Arg Val Ser Tyr Arg Ser Val Met Ser Gly Val Gly 1 5 10 15 Glu Glu Arg Val Pro Ser Ala Phe Thr Ile Leu Ala Ser Trp Gly Trp 20 25 30

Thr Phe Ala Pro Gin Asn His Asp Pro Gly Asp Asn Thr Thr Pro lie

35 40 45

Glu Ser Ile Ala Gly Thr Ala Pro Asp Ala His Val Gly Pro Leu Asp 50 55 60

Gly Glu Pro Asp Arg Asp Ala Ile Ser Pro Leu Thr Ser Ser Val Ala 65 70 75 80

Gly Asp Pro Pro Gly Ala Asp Gly Pro Tyr Val Thr Phe Asp Thr Leu 85 90 95 Phe Met Val Ser Ser Ile Asp Glu Leu Gly Arg Arg Gin Leu Thr Asp 100 105 110

Thr Ile Arg Lys Asp Leu Arg Leu Ser Leu Ala Lys Phe Ser Ile Ala

115 120 125

Cys Thr Lys Thr Ser Ser Phe Ser Gly Thr Ala Ala Arg Gin Arg Lys 130 135 140

Arg Gly Ala Pro Pro Gin Arg Thr Cys Val Pro Arg Ser Asn Lys Ser 145 150 155 160

Leu Gin Met Phe Val Leu Cys Lys Arg Ala Asn Ala Ala Gin Val Arg 165 170 175 Glu Gin Leu Arg Ala Val Ile Arg Ser Arg Lys Pro Arg Lys Tyr Tyr 180 185 190

Thr Arg Ser Ser Asp Gly Arg Leu Cys Pro Ala Val Pro Val Phe Val 195 200 205 His Glu Phe Val Ser Ser Glu Pro Met Arg Leu His Arg Asp Asn Val

210 215 220

Met Leu Ser Thr Glu Pro Asp , 225 230

(2) INFORMATION FOR SEQ ID NO: 221:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 199 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 221:

Met Gly Asn Pro Gin Thr Thr Ile Ala Tyr Ser Leu His His Pro Arg 1 5 10 15 Ala Ser Leu Thr Ser Ala Leu Pro Asp Ala Ala Gin Val Val His Val 20 25 30

Phe Glu Ser Gly Thr Arg Ala Val Leu Thr Arg Gly Arg Ala Arg Gin

35 40 45 Asp Arg Leu Pro Arg Gly Gly Val Val Ile Gin His Thr Pro Ile Gly 50 55 60

Leu Leu Val Ile Ile Asp Cys Arg Ala Glu Phe Cys Ala Tyr Arg Phe

65 70 75 80

Ile Gly Arg Ala Ser Thr Gin Arg Leu Glu Arg Trp Trp Asp Ala His

85 90 95 Met Tyr Ala Tyr Pro Phe Asp Ser Trp Val Ser Ser Ser His Gly Glu 100 105 110

Ser Val Arg Ser Ala Thr Ala Gly Ile Leu Thr Val Val Trp Thr Pro 115 120 125 Asp Thr Ile Tyr Ile Thr Ala Thr Ile Tyr Gly Thr Ala Pro Glu Ala 130 135 140

Arg Cys Asp Asn Ala Pro Leu Asp Val Arg Pro Thr Thr Pro Pro Ala

145 150 155 160

Pro Val Ser Pro Thr Ala Gly Glu Phe Pro Ala Asn Thr Thr Asp Leu

165 170 175 Leu Val Glu Val Leu Arg Glu Ile Gin Ile Ser Pro Thr Leu Asp Asp 180 185 190

Ala Asp Pro Thr Pro Gly Thr 195 (2) INFORMATION FOR SEQ ID NO: 222:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 877 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 222:

Met Ala Ala Ser Gly Gly Glu Gly Ser Arg Asp Val Arg Ala Pro Gly 1 5 10 15

Pro Pro Pro Gin Gin Pro Gly Ala Arg Pro Ala Val Arg Phe Arg Asp

20 25 30

Glu Ala Phe Leu Asn Phe Thr Ser Met His Gly Val Gin Pro Ile Ile 35 40 45 Ala Arg Ile Arg Glu Leu Ser Gin Gin Gin Leu Asp Val Thr Gin Val 50 55 60

Pro Arg Leu Gin Trp Phe Arg Asp Val Ala Ala Leu Glu Val Pro Thr 65 70 75 80

Gly Leu Pro Leu Arg Glu Phe Pro Phe Ala Ala Tyr Leu Ile Thr Gly 85 90 95

Asn Ala Gly Ser Gly Lys Ser Thr Cys Val Gin Thr Leu Asn Glu Val

100 105 110

Leu Asp Cys Val Val Thr Gly Ala Thr Arg Ile Ala Ala Gin Asn Met 115 120 125 Tyr Val Lys Leu Ser Gly Ala Phe Leu Ser Arg Pro Ile Asn Thr Ile 130 135 140

Phe His Glu Phe Gly Phe Arg Gly Asn His Val Gin Ala Gin Leu Gly 145 150 155 160

Gin His Pro Tyr Thr Leu Ala Ser Ser Pro Ala Ser Leu Glu Asp Leu 165 170 175

Gin Arg Arg Asp Leu Thr Tyr Tyr Trp Glu Val Ile Leu Asp Ile Thr

180 185 190

Lys Arg Ala Ala His Gly Gly Glu Asp Ala Arg Asn Glu Phe His Ala 195 200 205 Leu Thr Ala Leu Glu Gin Thr Leu Gly Leu Gly Gin Gly Ala Leu Thr 210 215 220

Arg Leu Ala Ser Val Thr His Gly Ala Leu Pro Ala Phe Thr Arg Ser 225 230 235 240 Asn Ile Ile Val Ile Asp Glu Ala Gly Leu Leu Gly Arg His Leu Leu

245 250 255

Thr Thr Val Val Tyr Cys Trp Trp Met Ile Asn Ala Leu Tyr His Thr 260 265 270 Pro Gin Tyr Ala Gly Arg Leu Arg Pro Val Leu Val Cys Val Gly Ser 275 280 285

Pro Thr Gin Thr Ala Ser Leu Glu Ser Thr Phe Glu His Gin Lys Leu

290 295 300

Arg Cys Ser Val Arg Gin Ser Glu Asn Val Leu Thr Tyr Leu Ile Cys 305 310 315 320

Asn Arg Thr Leu Arg Glu Tyr Thr Arg Leu Ser His Ser Trp Ala Ile

325 330 335

Phe Ile Asn Asn Lys Arg Cys Val Glu His Glu Phe Gly Asn Leu Met 340 345 350 Lys Val Leu Glu Tyr Gly Leu Pro Ile Thr Glu Glu His Met Gin Phe 355 360 365

Val Asp Arg Phe Val Val Pro Glu Ser Tyr Ile Thr Asn Pro Ala Asn

370 375 380

Leu Pro Gly Trp Thr Arg Leu Phe Ser Ser His Lys Glu Val Ser Ala 385 390 395 400

Tyr Met Ala Lys Leu His Ala Tyr Leu Lys Val Thr Arg Glu Gly Glu

405 410 415

Phe Val Val Phe Thr Leu Pro Val Leu Thr Phe Val Ser Val Lys Glu 420 425 430 Phe Asp Glu Tyr Arg Arg Leu Thr Gin Gin Pro Thr Leu Thr Met Glu 435 440 445

Lys Trp Ile Thr Ala Asn Ala Ser Arg Ile Thr Asn Tyr Ser Gin Ser

450 455 460

Gin Asp Gin Asp Ala Gly His Val Arg Cys Glu Val His Ser Lys Gin 465 470 475 480

Gin Leu Val Val Ala Arg Asn Asp Ile Thr Tyr Val Leu Asn Ser Gin

485 490 495

Val Ala Val Thr Ala Arg Leu Arg Lys Met Val Phe Gly Phe Asp Gly 500 505 510 Thr Phe Arg Thr Phe Glu Ala Val Leu Arg Asp Asp Ser Phe Val Lys 515 520 525

Thr Gin Gly Glu Thr Ser Val Glu Phe Ala Tyr Arg Phe Leu Ser Arg

530 535 540

Leu Met Phe Gly Gly Leu Ile His Phe Tyr Asn Phe Leu Gin Arg Pro 545 550 555 560

Gly Leu Asp Ala Thr Gin Arg Thr Leu Ala Tyr Gly Arg Leu Gly Glu

565 570 575

Leu Thr Ala Glu Leu Leu Ser Leu Arg Arg Asp Ala Ala Gly Ala Ser 580 585 590

Ala Thr Arg Ala Ala Asp Thr Ser Asp Arg Ser Pro Gly Glu Arg Ala

595 .600 605

Phe Asn Phe Lys His Leu Gly Pro Arg Asp Gly Gly Pro Asp Asp Phe 610 615 620

Pro Asp Asp Asp Leu Asp Val Ile Phe Ala Gly Leu Asp Glu Gin Gin

625 630 635 640

Leu Asp Val Phe Tyr Cys His Tyr Ala Leu Glu Glu Pro Glu Thr Thr

645 650 655 Ala Ala Val His Ala Gin Phe Gly Leu Leu Lys Arg Ala Phe Leu Gly

660 665 670

Arg Tyr Leu Ile Leu Arg Glu Leu Phe Gly Glu Val Phe Glu Ser Ala

675 680 685

Pro Phe Ser Thr Tyr Val Asp Asn Val Ile Phe Arg Gly Cys Glu Leu 690 695 700

Leu Thr Gly Ser Pro Arg Gly Gly Leu Met Ser Val Gin Thr Asp Asn

705 710 715 720

Tyr Thr Leu Met Gly Tyr Thr Tyr Thr Arg Val Phe Ala Phe Ala Glu

725 730 735 Glu Leu Arg Arg Arg His Ala Thr Ala Gly Val Ala Glu Phe Leu Glu

740 745 750

Glu Ser Pro Leu Pro Tyr Ile Val Leu Arg Asp Gin His Gly Phe Met

755 760 765

Ser Val Val Asn Thr Asn Ile Ser Glu Phe Val Glu Ser Ile Asp Ser 770 775 780

Thr Glu Leu Ala Met Ala Ile Asn Ala Asp Tyr Gly Ile Ser Ser Lys

785 790 795 800

Leu Ala Met Thr Ile Thr Arg Ser Gin Gly Leu Ser Leu Asp Lys Val

805 810 815 Ala Ile Cys Phe Thr Pro Gly Asn Leu Arg Leu Asn Ser Ala Tyr Val

820 825 830

Ala Met Ser Arg Thr Thr Ser Ser Glu Phe Leu His Met Asn Leu Asn

835 840 845

Pro Leu Arg Glu Arg His Glu Arg Asp Asp Val Ile Ser Glu His Ile 850 855 860

Leu Ser Ala Leu Arg Asp Pro Asn Val Val Ile Val Tyr 865 870 875

(2) INFORMATION FOR SEQ ID NO: 223:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 292 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:223:

Met Ala Asp Pro Thr Pro Ala Asp Glu Gly Thr Ala Ala Ala Ile Leu 1 5 10 15 Lys Gin Ala Ile Ala Gly Asp Arg Ser Leu Val Glu Val Ala Glu Gly 20 25 30

Ile Ser Asn Gin Ala Leu Leu Arg Met Ala Cys Glu Val Arg Gin Val

35 40 45

Ser Asp Arg Gin Pro Arg Phe Thr Ala Thr Ser Val Leu Arg Val Asp 50 55 60

Val Thr Pro Arg Gly Arg Leu Arg Phe Val Leu Asp Gly Ser Ser Asp 65 70 75 80

Asp Ala Tyr Val Ala Ser Glu Asp Tyr Phe Lys Arg Cys Gly Asp Gin 85 90 95 Pro Tyr Gly Phe Ala Val Val Val Leu Thr Ala Asn Glu Asp His Val 100 105 110

His Ser Leu Ala Val Pro Pro Leu Val Leu Leu His Arg Leu Ser Leu

115 120 125

Phe Arg Pro Thr Asp Leu Arg Asp Phe Glu Leu Val Cys Leu Leu Met 130 135 140

Tyr Leu Glu Asn Cys Pro Arg Ser His Ala Thr Pro Ser Leu Phe Val

145 150 155 160

Lys Val Ser Ala Trp Leu Gly Val Val Ala Arg His Asp Phe Glu Arg

165 170 175 Val Arg Cys Leu Leu Leu Arg Ser Cys His Trp Ile Leu Asn Thr Leu

180 185 190

Met Cys Met Ala Gly Val Lys Pro Phe Asp Asp Glu Leu Val Leu Pro

195 200 205

His Trp Tyr Met Ala His Tyr Leu Leu Ala Asn Asn Pro Pro Pro Val 210 215 220

Leu Ser Ala Leu Phe Cys Ala Thr Pro Gin Ser Ser Ala Leu Gin Leu 225 230 235 240

Pro Gly Pro Val Pro Arg Thr Asp Cys Val Ala Tyr Asn Pro Ala Gly 245 250 255 Val Met Gly Ser Cys Trp Lys Ser Lys Asp Leu Arg Ser Ala Leu Val 260 265 270

Tyr Trp Trp Leu Ser Gly Ser Pro Lys Arg Arg Thr Ser Ser Leu Phe 275 280 285 Tyr Arg Phe Cys 290

(2) INFORMATION FOR SEQ ID NO: 224:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 734 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 224:

Met Glu Ala Pro Gly Ile Val Trp Val Glu Glu Ser Val Ser Ala lie

1 5 10 15

Thr Leu Tyr Ala Val Trp Leu Pro Pro Arg Thr Arg Asp Cys Leu His 20 25 30 Ala Leu Leu Tyr Leu Val Cys Arg Asp Ala Ala Gly Glu Ala Arg Ala 35 40 45

Arg Phe Ala Glu Val Ser Val Gly Ser Ser Asp Leu Gin Asp Phe Tyr

50 55 60

Gly Ser Pro Asp Val Ser Ala Ala Gly Ala Val Ala Ala Ala Arg Ala 65 70 75 80

Ala Pro Ala Asp Leu Glu Pro Leu Gly Asp Pro Thr Leu Trp Arg Ala

85 90 95

Leu Tyr Ala Cys Val Leu Ala Ala Leu Glu Arg Gin Thr Gly Pro Val 100 105 110 Phe Val Pro Leu Arg Leu Gly Trp Asp Pro Gin Thr Gly Leu Val Val 115 120 125

Arg Val Glu Arg Ala Ser Trp Gly Pro Pro Ala Ala Pro Arg Ala Ala

130 135 140

Leu Leu Asp Val Glu Ala Lys Val Asp Val Asp Pro Leu Ala Ala Arg 145 150 155 160

Val Ala Glu His Pro Gly Ala Arg Leu Ala Trp Ala Arg Leu Ala Ala

165 170 175

Ile Arg Asp Ser Pro Gin Cys Ala Ser Ser Ala Ser Leu Ala Val Thr 180 185 190 Ile Thr Thr Arg Thr Ala Arg Phe Ala Arg Glu Tyr Thr Thr Leu Ala 195 200 205

Phe Pro Pro Thr Ser Lys Glu Gly Ala Phe Ala Asp Leu Val Glu Val 210 215 220 Cys Glu Val Gly Leu Arg Pro Arg Gly His Pro Gin Arg Val Thr Ala

225 230 235 240

Arg Val Leu Leu Pro Arg Gly Tyr Asp Tyr Phe Val Ser Ala Gly Asp

245 250 255 Gly Phe Ser Ala Pro Ala Leu Val Phe Arg Gin Trp His Thr Thr Val

260 265 270

His Ala Ala Pro Gly Ala Pro Val Phe Ala Phe Leu Gly Pro Gly Phe

275 280 285

Glu Val Arg Gly Gly Pro Val Gin Tyr Phe Ala Val Leu Gly Phe Pro 290 295 300

Gly Trp Pro Thr Phe Thr Val Pro Ala Ala Ala Ala Ala Glu Ser Ala

305 310 315 320

Arg Asp Leu Val Arg Gly Ala Ala Ala Thr His Ala Ala Cys Leu Gly

325 330 335 Ala Trp Pro Ala Val Gly Ala Arg Val Val Leu Pro Pro Arg Ala Trp

340 345 350

Pro Ala Val Ala Ser Glu Ala Ala Gly Arg Leu Leu Pro Ala Phe Arg

355 360 365

Glu Ala Val Ala Arg Trp His Pro Thr Ala Thr Thr Ile Gin Leu Leu 370 375 380

Asp Pro Pro Ala Ala Val Gly Pro Val Trp Thr Ala Arg Phe Cys Phe

385 390 395 400

Ser Gly Leu Gin Ala Gin Leu Leu Ala Ala Gly Leu Gly Glu Ala Gly

405 410 415 Leu Pro Glu Arg Arg Ala Gly Leu Glu Arg Leu Asp Ala Leu Val Ala

420 425 430

Ala Ala Pro Ser Glu Pro Trp Ala Arg Ala Val Leu Glu Arg Leu Val

435 440 445

Pro Asp Ala Cys Asp Ala Cys Pro Ala Leu Arg Gin Leu Leu Gly Gly 450 455 460

Val Met Ala Ala Val Cys Leu Gin Ile Glu Gin Thr Ala Ser Ser Val

465 470 475 480

Lys Phe Ala Val Cys Gly Gly Thr Gly Ala Ala Phe Trp Gly Leu Phe

485 490 495 Asn Val Asp Pro Gly Asp Ala Asp Ala Ala His Gly Ala Ile Gin Asp

500 505 510

Ala Arg Arg Ala Leu Glu Ala Ser Val Arg Ala Val Leu Ser Ala Asn

515 520 525

Gly Ile Arg Pro Arg Leu Ala Pro Ser Leu Ala Leu Glu Gly Val Tyr 530 535 540

Thr His Val Val Thr Trp Ser Gin Thr Gly Ala Trp Phe Trp Asn Ser 545 550 555 560

Arg Asp Asp Thr Asp Phe Leu Gin Gly Phe Pro Leu Arg Gly Pro Ala 565 570 575

Tyr Ala Ala Ala Ala Glu Val Met Arg Asp Ala Leu Arg Arg Ile Leu

580 - 585 590

Arg Arg Pro Ala Ala Gly Pro Pro Glu Glu Ala Val Cys Ala Arg Ile 595 600 605

Met Glu Asp Ala Cys Asp Arg Phe Val Leu Asp Ala Phe Gly Arg Arg

610 615 620

Leu Asp Ala Glu Tyr Trp Ser Val Leu Thr Pro Pro Gly Glu Ala Asp 625 630 635 640 Asp Pro Leu Pro Gin Thr Ala Phe Arg Gly Gly Ala Leu Leu Asp Ala

645 650 655

Glu Gin Tyr Trp Arg Arg Val Val Arg Val Cys Pro Gly Gly Gly Glu

660 665 670

Ser Val Gly Val Pro Val Asp Leu Tyr Pro Arg Pro Leu Val Leu Pro 675 680 685

Pro Val Asp Cys Ala His His Leu Arg Glu Ile Leu Arg Glu Ile Gin

690 695 700

Leu Val Phe Thr Gly Val Leu Glu Gly Val Trp Gly Glu Gly Gly Ser 705 710 715 720 Phe Val Tyr Pro Phe Glu Glu Lys Met Arg Phe Leu Phe Pro

725 730

(2) INFORMATION FOR SEQ ID NO: 225:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 461 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 225:

Met Gly Arg Arg Ala Pro Arg Gly Ser Pro Glu Ala Ala Pro Gly Ala 1 5 10 15

Asp Val Ala Pro Gly Ala Arg Ala Ala Trp Trp Val Trp Cys Val Gin

20 25 30

Val Ala Thr Phe Ile Val Ser Ala Ile Cys Val Val Gly Leu Leu Val 35 40 45

Leu Ala Ser Val Phe Arg Asp Arg Phe Pro Cys Leu Tyr Ala Pro Ala

50 55 60

Thr Ser Tyr Ala Glu Ala Asn Ala Thr Val Glu Val Arg Gly Gly Val 65 70 75 80

Ala Val Pro Leu Arg Leu Asp Thr Gin Ser Leu Leu Ala Thr Tyr Ala

85 - 90 95

Ile Thr Ser Thr Leu Leu Leu Ala Ala Ala Val Tyr Ala Ala Val Gly 100 105 110

Ala Val Thr Ser Arg Tyr Glu Arg Ala Leu Asp Ala Ala Arg Arg Leu

115 120 125

Ala Ala Ala Arg Met Ala Met Pro His Ala Thr Leu Ile Ala Gly Asn

130 135 140 Val Cys Ala Trp Leu Leu Gin Ile Thr Val Leu Leu Leu Ala His Arg

145 150 155 160

Ile Ser Gin Leu Ala His Leu Ile Tyr Val Leu His Phe Ala Cys Leu

165 170 175

Val Tyr Leu Ala Ala His Phe Cys Thr Arg Gly Val Leu Ser Gly Thr 180 185 190

Tyr Leu Arg Gin Val His Gly Leu Ile Asp Pro Ala Pro Thr His His

195 200 205

Arg Ile Val Gly Pro Val Arg Ala Val Met Thr Asn Ala Leu Leu Leu

210 215 220 Gly Thr Leu Leu Cys Thr Ala Ala Ala Ala Val Ser Leu Asn Thr Ile

225 230 235 240

Ala Ala Leu Asn Phe Asn Phe Ser Ala Pro Ser Met Leu Ile Cys Leu

245 250 255

Thr Thr Leu Phe Ala Leu Leu Val Val Ser Leu Leu Leu Val Val Glu 260 265 270

Gly Val Leu Cys His Tyr Val Arg Val Leu Val Gly Pro His Leu Gly

275 280 285

Ala Ile Ala Ala Thr Gly Ile Val Gly Leu Ala Cys Glu His Tyr His

290 295 300 Thr Gly Gly Tyr Tyr Val Val Glu Gin Gin Trp Pro Gly Ala Gin Thr

305 310 315 320

Gly Val Arg Val Val Ala Ala Phe Ala Met Ala Val Leu Arg Cys Thr

325 330 335

Arg Ala Tyr Leu Tyr His Arg Arg His His Thr Lys Phe Phe Val Arg 340 345 350

Met Arg Asp Thr Arg His Arg Ala His Ser Ala Leu Arg Arg Val Arg

355 360 365

Ser Ser Met Arg Gly Ser Arg Arg Gly Gly Pro Pro Gly Asp Pro Gly 370 375 380 Tyr Ala Glu Thr Pro Tyr Ala Ser Val Ser His His Ala Glu Ile Asp 385 390 395 400

Arg Tyr Gly Asp Ser Asp Gly Asp Pro Ile Tyr Asp Glu Val Ala Pro 405 410 415 Asp His Glu Ala Glu Leu Tyr Ala Arg Val Gin Arg Pro Gly Pro Val

420 425 430

Pro Asp Ala Glu Pro Ile Tyr Asp Thr Val Glu Gly Tyr Ala Pro Arg 435 440 445 Ser Ala Gly Glu Pro Val Tyr Ser Thr Val Arg Arg Trp 450 455 460

(2) INFORMATION FOR SEQ ID NO: 226:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 96 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 226:

Met Gly Leu Ala Phe Ser Gly Ala Arg Pro Cys Cys Cys Arg His Asn

1 5 10 15

Val Ile Ile Thr Asp Gly Gly Glu Val Val Ser Leu Thr Ala His Glu

20 25 30

Phe Asp Val Val Asp Ile Glu Ser Glu Glu Glu Gly Asn Phe Tyr Val 35 40 45

Pro Pro Asp Met Arg Val Val Thr Arg Ala Pro Gly Pro Gin Tyr Arg

50 55 60

Arg Ala Ser Asp Pro Pro Ser Arg His Thr Arg Arg Arg Asp Pro Asp 65 70 75 80 Val Ala Arg Pro Pro Ala Thr Leu Thr Pro Pro Leu Ser Asp Ser Glu

85 90 95

(2) INFORMATION FOR SEQ ID NO: 227:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 618 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 227: Met Ala Ala Ala Ala Thr Pro Gly Ala Lys Arg Pro Ala Asp Pro Ala

1 5 _. 10 15

Arg Asp Pro Asp Ser Pro Pro Lys Arg Pro Arg Pro Asn Ser Leu Asp 20 25 30

Leu Ala Thr Val Phe Gly Pro Arg Pro Ala Pro Pro Arg Pro Thr Ser

35 40 45

Pro Gly Ala Pro Gly Ser His Trp Pro Gin Ser Pro Pro Arg Gly Gin 50 55 60 Pro Asp Gly Gly Ala Pro Gly Glu Lys Ala Arg Pro Asp Ala Leu Ser 65 70 75 80

Glu Ala Ser Ser Gly Pro Pro Thr Pro Asp Ile Pro Leu Ser Pro Gly

85 90 95

Gly Ala His Ala Ile Asp Pro Asp Cys Ser Pro Gly Pro Pro Asp Pro 100 105 110

Asp Pro Met Trp Ser Ala Ser Ala Ile Pro Asn Ala Leu Pro Pro His

115 120 125

Ile Leu Ala Glu Thr Phe Glu Arg His Leu Arg Gly Leu Leu Arg Gly

130 135 140 Val Arg Ser Pro Leu Ala Ile Gly Pro Leu Trp Ala Arg Leu Asp Tyr

145 150 155 160

Leu Cys Ser Leu Val Val Ser Leu Glu Ala Ala Gly Met Val Asp Arg

165 170 175

Gly Leu Gly Arg His Leu Trp Arg Leu Thr Arg Arg Ala Pro Pro Ser 180 185 190

Ala Ala Glu Ala Val Ala Pro Arg Pro Leu Met Gly Phe Tyr Glu Ala

195 200 205

Ala Thr Gin Asn Gin Ala Asp Cys Gin Leu Trp Ala Leu Leu Arg Arg

210 215 220 Gly Leu Thr Thr Ala Ser Thr Leu Arg Trp Gly Ala Gin Gly Pro Cys

225 230 235 240

Phe Ser Ser Gin Trp Leu Thr His Asn Ala Ser Leu Arg Leu Asp Ala

245 250 255

Gin Ser Ser Ala Val Met Phe Gly Arg Val Asn Glu Pro Thr Ala Arg 260 265 270

Asn Leu Leu Phe Arg Tyr Cys Val Gly Arg Ala Asp Ala Gly Val Asn

275 280 285

Asp Asp Ala Asp Ala Gly Arg Phe Val Phe His Gin Pro Gly Asp Leu 290 295 300 Ala Glu Glu Asn Val His Ala Cys Gly Val Leu Met Asp Gly His Thr 305 310 315 320

Gly Met Val Gly Ala Ser Leu Asp Ile Leu Val Cys Pro Arg Asp Pro 325 330 335 His Gly Tyr Leu Ala Pro Ala Pro Gin Thr Pro Leu Ala Phe Tyr Glu

340 345 350

Val Lys Cys Arg Ala Lys Tyr. Ala Phe Asp Pro Ala Asp Pro Gly Ala 355 360 365 Pro Ala Ala Ser Ala Tyr Glu Asp Leu Met Ala Arg Arg Ser Pro Glu 370 375 380

Ala Phe Arg Ala Phe Ile Arg Ser Ile Pro Asn Pro Gly Val Arg Tyr 385 390 395 400

Phe Ala Pro Gly Arg Val Pro Gly Pro Glu Glu Ala Leu Val Thr Gin 405 410 415

Asp Arg Asp Trp Leu Asp Ser Arg Ala Ala Gly Glu Lys Arg Arg Cys

420 425 430

Ser Ala Pro Asp Arg Ala Leu Val Glu Leu Asn Ser Gly Val Val Ser 435 440 445 Glu Val Leu Leu Phe Gly Val Pro Asp Leu Glu Arg Arg Thr Ile Ser 450 455 460

Pro Val Ala Trp Ser Ser Gly Glu Leu Val Arg Arg Glu Pro Ile Phe 465 470 475 480

Ala Asn Pro Arg His Pro Asn Phe Lys Gin Ile Leu Val Gin Gly Tyr 485 490 495

Val Leu Asp Ser His Phe Pro Asp Cys Pro Leu Gin Pro His Leu Val

500 505 510

Thr Phe Leu Gly Arg His Arg Ala Gly Ala Glu Glu Gly Val Thr Phe 515 520 525 Arg Leu Glu Asp Gly Arg Gly Ala Pro Ala Gly Arg Gly Gly Ala Pro 530 535 540

Gly Pro Ala Lys Ala Ser Ile Leu Pro Asp Gin Ala Val Pro Ile Ala 545 550 555 560

Leu Ile Ile Thr Pro Val Arg Val Glu Pro Gly Ile Tyr Arg Asp Ile 565 570 575

Arg Arg Asn Ser Arg Leu Ala Phe Asp Asp Thr Leu Ala Lys Leu Trp

580 585 590

Ala Ser Arg Ser Pro Gly Arg Gly Pro Ala Ala Ala Asp Thr Thr Ser 595 600 605 Ser Ser Pro Thr Ala Gly Arg Ser Ser Arg 610 615

(2) INFORMATION FOR SEQ ID NO: 228:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 516 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 228:

Met Asp Glu Ser Gly Arg Gin Arg Pro Ala Ser His Val Ala Ala Asp

1 5 10 15

Ile Ser Pro Gin Gly Ala His Arg Arg Ser Phe Lys Ala Trp Leu Ala 20 25 30

Ser Tyr Ile His Ser Leu Ser Arg Arg Ala Ser Gly Arg Pro Ser Gly

35 40 45

Pro Ser Pro Arg Asp Gly Ala Val Ser Gly Ala Arg Pro Gly Ser Arg 50 55 60 Arg Arg Ser Ser Phe Arg Glu Arg Leu Arg Ala Gly Leu Ser Arg Trp 65 70 75 80

Arg Val Ser Arg Ser Ser Arg Arg Arg Ser Ser Pro Glu Ala Pro Gly

85 90 95

Pro Ala Ala Lys Leu Arg Arg Pro Pro Leu Arg Arg Ser Glu Thr Ala 100 105 110

Met Thr Ser Pro Pro Ser Pro Pro Ser His Ile Leu Ser Leu Ala Arg

115 120 125

Ile His Lys Leu Cys Ile Pro Val Phe Ala Val Asn Pro Ala Leu Arg

130 135 140 Tyr Thr Thr Leu Glu Ile Pro Gly Ala Arg Ser Phe Gly Gly Ser Gly

145 150 155 160

Gly Tyr Gly Glu Val Gin Leu Ile Arg Glu His Lys Leu Ala Val Lys

165 170 175

Thr lie Arg Glu Lys Glu Trp Phe Ala Val Glu Leu Val Ala Thr Leu 180 185 190

Leu Val Gly Glu Cys Ala Leu Arg Gly Gly Arg Thr His Asp Ile Arg

195 200 205

Gly Phe Ile Thr Pro Leu Gly Phe Ser Leu Gin Gin Arg Gin Ile Val

210 215 220 Phe Pro Ala Tyr Asp Met Asp Leu Gly Lys Tyr Ile Gly Gin Leu Ala

225 230 235 240

Ser Leu Arg Ala Thr Thr Pro Ser Val Ala Thr Ala Leu His His Cys

245 250 255

Phe Thr Asp Leu Ala Arg Ala Val Val Phe Leu Asn Thr Arg Cys Gly 260 265 270

Ile Ser His Leu Asp Ile Lys Cys Ala Asn Val Leu Val Met Leu Arg

275 280 285

Ser Asp Ala Val Ser Leu Arg Arg Ala Val Leu Ala Asp Phe Ser Leu 290 295 300

Val Thr Leu Asn Ser Asn Ser Thr Ile Ser Arg Gly Gin Phe Cys Leu 305 310 , 315 320

Gin Glu Pro Asp Leu Glu Ser Pro Arg Gly Phe Gly Met Pro Ala Ala 325 330 335

Leu Thr Thr Ala Asn Phe His Thr Leu Val Gly His Gly Tyr Asn Gin

340 345 350

Pro Pro Glu Leu Leu Val Lys Tyr Leu Asn Asn Glu Arg Ala Glu Phe 355 360 365 Asn Asn Arg Pro Leu Lys His Asp Val Gly Leu Ala Val Asp Leu Tyr 370 375 380

Ala Leu Gly Gin Thr Leu Leu Glu Leu Leu Val Ser Val Tyr Val Ala 385 390 395 400

Pro Ser Leu Gly Val Pro Val Thr Arg Val Pro Gly Tyr Gin Tyr Phe 405 410 415

Asn Asn Gin Leu Ser Pro Asp Phe Ala Val Leu Ala Tyr Arg Cys Val

420 425 430

Leu His Pro Ala Leu Phe Val Asn Ser Ala Glu Thr Asn Thr His Gly 435 440 445 Leu Ala Tyr Asp Val Pro Glu Gly Ile Arg Arg His Leu Arg Asn Pro 450 455 460

Lys Ile Arg Arg Ala Phe Thr Glu Gin Cys Ile Asn Tyr Gin Arg Thr 465 470 475 480

His Lys Ala Val Leu Ser Ser Val Ser Leu Pro Pro Glu Leu Arg Pro 485 490 495

Leu Leu Val Leu Val Ser Arg Leu Cys His Ala Asn Pro Ala Ala Arg

500 505 510

His Ser Leu Ser 515

(2) INFORMATION FOR SEQ ID NO: 229:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 217 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 229:

Met Ser Arg Asp Ala Ser His Ala Ala Leu Arg Arg Arg Leu Ala Glu 1 5 10 15

Thr His Leu Arg Ala Glu Val Tyr Arg Asp Gin Thr Leu Gin Leu His

20 25 30 Arg Glu Gly Val Ser Thr Gin Asp Pro Arg Phe Val Gly Ala Phe Met 35 40 45

Ala Ala Lys Ala Ala His Leu Glu Leu Glu Ala Arg Leu Lys Ser Arg

50 55 60

Ala Arg Leu Glu Met Met Arg Gin Arg Ala Thr Cys Val Lys Ile Arg 65 70 75 80 Val Glu Glu Gin Ala Ala Arg Arg Asp Phe Leu Thr Ala His Arg Arg

85 90 95 Tyr Leu Asp Pro Ala Leu Ser Leu Asp Ala Ala Asp Asp Arg Leu Ala

100 105 110 Asp Gin Glu Glu Gin Leu Glu Glu Ala Ala Ala Asn Ala Ser Leu Trp 115 120 125

Gly Asp Gly Asp Leu Ala Asp Gly Trp Met Ser Pro Gly Asp Ser Asp

130 135 140

Leu Leu Val Met Trp Gin Leu Thr Ser Ala Pro Lys Val His Thr Asp

145 150 155 160 Ala Pro Ser Arg Pro Gly Ser Arg Pro Thr Tyr Thr Pro Ser Ala Ala

165 170 175 Gly Arg Pro Asp Ala Gin Ala Ala Pro Pro Pro Glu Thr Ala Pro Ser

180 185 190 Pro Glu Pro Ala Pro Gly Pro Ala Ala Asp Pro Ala Ser Gly Ser Gly 195 200 205

Phe Ala Arg Asp Cys Pro Asp Gly Glu 210 215

(2) INFORMATION FOR SEQ ID NO: 230:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 430 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 230:

Met Phe Gly Gin Gin Leu Ala Ser Asp Val Gin Gin Tyr Leu Glu Arg

1 5 10 15

Leu Glu Lys Gin Arg Gin Gin Lys Val Gly Val Asp Glu Ala Ser Ala 20 25 30

Gly Leu Thr Leu Gly Gly Asp Ala Leu Arg Val Pro Phe Leu Asp Phe

35 -40 45

Ala Thr Ala Thr Pro Lys Arg His Gin Thr Val Val Pro Gly Val Gly 50 55 60

Thr Leu His Asp Cys Cys Glu His Ser Pro Leu Phe Ser Ala Val Ala 65 70 75 80

Arg Arg Leu Leu Phe Asn Ser Leu Val Pro Ala Gin Leu Arg Gly Arg 85 90 95 Asp Phe Gly Gly Asp His Thr Ala Lys Leu Glu Phe Leu Ala Pro Glu 100 105 110

Leu Val Arg Ala Val Ala Arg Leu Arg Phe Arg Glu Cys Ala Pro Glu

115 120 125

Asp Ala Val Pro Gin Arg Asn Ala Tyr Tyr Ser Val Leu Asn Thr Phe 130 135 140

Gin Ala Leu His Arg Ser Glu Ala Phe Arg Gin Leu Val His Phe Val

145 150 155 160

Arg Asp Phe Ala Gin Leu Leu Lys Thr Ser Phe Arg Ala Ser Ser Leu

165 170 175 Ala Glu Thr Thr Gly Pro Pro Lys Lys Arg Ala Lys Val Asp Val Ala

180 185 190

Thr His Gly Gin Thr Tyr Gly Thr Leu Glu Leu Phe Gin Lys Met Ile

195 200 205

Leu Met His Ala Thr Tyr Phe Leu Ala Ala Val Leu Leu Gly Asp His 210 215 220

Ala Glu Gin Val Asn Thr Phe Leu Arg Leu Val Phe Glu Ile Pro Leu

225 230 235 240

Phe Ser Asp Thr Ala Val Arg His Phe Arg Gin Arg Ala Thr Val Phe

245 250 255 Leu Val Pro Arg Arg His Gly Lys Thr Trp Phe Leu Val Pro Leu Ile

260 265 270

Ala Leu Ser Leu Ala Ser Phe Arg Gly Ile Lys Ile Gly Tyr Thr Ala

275 280 285

His Ile Arg Lys Ala Thr Glu Pro Val Phe Asp Glu Ile Asp Ala Cys 290 295 300

Leu Arg Gly Trp Phe Gly Ser Ser Arg Val Asp His Val Lys Gly Glu 305 310 315 320

Thr Ile Ser Phe Ser Phe Pro Asp Gly Ser Arg Ser Thr Ile Val Phe 325 330 335 Ala Ser Ser His Asn Thr Asn Val Ser Thr Pro Ser Ser Arg Gly Ala 340 345 350

Cys Phe Pro Gly Ala Ala Leu Pro Glu Ile Asp Arg Gin Thr Asn Thr 355 360 365 Ala Arg Arg Glu Cys Gly Thr Trp Gin Pro Pro Pro Pro Trp Arg Gly

370 375 380

Glu Ala Leu Leu Phe Ile Cys Asn Arg Thr Met Arg Leu Trp Pro Arg 385 390 395 400 Pro Ala Arg Pro Arg Gly Ser Ser Leu Gin Thr Gly Gly Trp Tyr Thr

405 410 415

Met Thr Glu Arg Arg Gly Ala Thr Arg Arg Trp Ser Gly Gly 420 425 430

(2) INFORMATION FOR SEQ ID NO: 231:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 315 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:231:

Val Trp Arg Val Val Arg Gly Asp Glu Arg Leu Lys Ile Phe Arg Cys

1 5 10 15

Leu Thr Val Leu Thr Glu Pro Leu Cys Gin Val Pro Asp Pro Asp Pro 20 25 30

Glu Arg Ala Leu Phe Cys Glu Ile Phe Leu Tyr Leu Trp Lys Ala Leu

35 40 45

Arg Leu Pro Ser Asn Thr Phe Phe Ala Ile Phe Phe Phe Asn Arg Glu 50 55 60 Arg Arg Tyr Cys Ala Thr Val His Leu Arg Ser Val Thr His Pro Arg 65 70 75 80

Thr Pro Leu Leu Cys Thr Leu Ala Phe Gly His Leu Glu Ala Asp Pro

85 90 95

Glu Glu Thr Pro Asp Pro Ala Ala Glu Gin Leu Ala Asp Glu Pro Val 100 105 110

Ala His Glu Leu Asp Gly Ala Tyr Leu Val Pro Thr Glu Pro Pro Pro

115 120 125

Asn Pro Gly Ala Cys Cys Ala Leu Gly Pro Gly Ala Trp Trp His Leu 130 135 140 Pro Gly Gly Arg Ile Tyr Cys Trp Ala Met Asp Asp Asp Leu Gly Ser 145 150 155 160

Leu Cys Pro Pro Gly Ser Arg Ala Arg His Leu Gly Trp Leu Leu Ser 165 170 175 Arg Ile Thr Asp Pro Pro Gly Gly Gly Gly Ala Cys Ala Pro Thr Ala

180 185 190

His Ile Asp Ser Ala Asn Ala- Leu Trp Arg Ala Pro Ala Val Ala Glu 195 200 205 Ala Cys Pro Cys Val Ala Pro Cys Met Trp Ser Asn Met Ala Gin Arg 210 215 220

Thr Leu Ala Val Arg Gly Asp Ala Ser Leu Cys Gin Leu Leu Phe Gly 225 230 235 240

His Pro Val Asp Ala Val Ile Leu Arg Gin Ala Thr Arg Arg Pro Arg 245 250 255

Ile Thr Ala His Leu His Glu Val Val Val Gly Arg Asp Gly Ala Glu

260 265 270

Ser Val Ile Arg Pro Thr Ser Ala Gly Trp Arg Leu Cys Val Leu Ser 275 280 285 Ser Tyr Thr Ser Arg Leu Phe Ala Thr Ser Cys Pro Ala Val Ala Arg 290 295 300

Ala Val Ala Arg Ala Ser Ser Ser Asp Tyr Lys 305 310 315

(2) INFORMATION FOR SEQ ID NO: 232:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 698 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 232:

Met Asn Ala His Phe Ala Asn Glu Val Gin Tyr Asp Leu Thr Arg Asp

1 5 10 15

Pro Ser Ser Pro Ala Ser Leu Ile His Val Ile Ile Ser Ser Glu Cys 20 25 30

Leu Ala Ala Ala Gly Val Pro Leu Ser Ala Leu Val Arg Gly Arg Pro

35 40 45

Asp Gly Gly Ala Ala Ala Asn Phe Arg Val Glu Thr Gin Thr Arg Ala 50 55 60 His Ala Thr Gly Asp Cys Thr Pro Trp Arg Ser Ala Phe Ala Ala Tyr 65 70 75 80

Val Pro Ala Asp Ala Val Gly Ala Ile Leu Ala Pro Val Ile Pro Ala 85 90 95 His Pro Asp Leu Leu Pro Arg Val Pro Ser Ala Gly Gly Leu Phe Val

100 105 110

Ser Leu Pro Val Ala Cys Asp- Ala Gin Gly Val Tyr Asp Pro Tyr Thr 115 120 125 Val Ala Ala Leu Arg Leu Ala Trp Gly Pro Trp Ala Thr Cys Ala Arg 130 135 140

Val Leu Leu Phe Ser Tyr Asp Glu Leu Val Pro Pro Asn Thr Arg Tyr 145 150 155 160

Ala Ala Asp Gly Ala Arg Leu Met Arg Leu Cys Arg His Phe Cys Arg 165 170 175

Tyr Val Ala Arg Leu Gly Ala Ala Ala Pro Ala Ala Ala Thr Glu Ala

180 185 190

Ala Ala His Leu Ser Leu Gly Met Gly Glu Ser Gly Thr Pro Thr Pro 195 200 205 Gin Ala Ser Ser Val Ser Gly Gly Ala Gly Pro Ala Val Val Gly Thr 210 215 220

Pro Asp Pro Pro Ile Ser Pro Glu Glu Gin Leu Thr Ala Pro Gly Gly 225 230 235 240

Asp Thr Ala Thr Ala Glu Asp Val Ser Ile Thr Gin Glu Asn Glu Glu 245 250 255

Ile Leu Ala Leu Val Gin Arg Ala Val Gin Asp Val Thr Arg Arg His

260 265 270

Pro Val Arg Ala Arg Pro Lys His Ala Ala Ser Gly Val Ala Ser Gly 275 280 285 Leu Arg Gin Gly Ala Leu Val His Gin Ala Val Ser Gly Gly Ala Leu 290 295 300

Gly Ala Ser Asp Ala Glu Ala Val Leu Ala Gly Leu Glu Pro Pro Gly 305 310 315 320

Gly Gly Arg Phe Ala Thr Pro Gly Gly Pro Arg Ala Ala Gly Glu Asp 325 330 335

Val Leu Asn Asp Val Leu Thr Leu Val Pro Gly Thr Ala Lys Pro Arg

340 345 350

Ser Leu Val Glu Trp Leu Asp Arg Gly Trp Glu Ala Gly Gly Asp Arg 355 360 365 Pro Asp Trp Leu Trp Ser Arg Arg Ser Ile Ser Val Val Leu Arg His 370 375 380

His Tyr Gly Thr Lys Gin Arg Phe Val Val Val Ser Tyr Glu Asn Ser 385 390 395 400

Val Ala Trp Gly Gly Arg Arg Ala Arg Pro Pro Arg Leu Ser Ser Glu 405 410 415

Leu Ala Thr Ala Leu Thr Glu Ala Cys Ala Ala Glu Arg Val Val Arg

420 425 430

Pro His Gin Leu Ser Pro Ala Ala Gin Thr Ala Leu Leu Arg Arg Phe 435 440 445

Pro Ala Leu Glu Gly Pro Leu Arg His Pro Arg Pro Val Leu Gin Pro

450 455 - 460

Phe Asp Ile Ala Ala Glu Val Ala Phe Val Ala Arg Ile Gin Ile Ala 465 470 475 480

Cys Leu Arg Ala Leu Gly His Ser Ile Arg Ala Ala Leu Gin Gly Gly

485 490 495

Pro Arg Ile Phe Gin Arg Leu Arg Tyr Asp Phe Gly Pro His Gin Ser 500 505 510 Glu Trp Leu Gly Glu Val Thr Arg Arg Phe Pro Val Leu Leu Glu Asn 515 520 525

Leu Met Arg Ala Leu Glu Gly Thr Ala Pro Asp Ala Phe Phe His Thr

530 535 540

Ala Tyr Ala Val Leu Ala His Leu Gly Gly Gin Gly Gly Arg Gly Arg 545 550 555 560

Arg Arg Arg Leu Val Pro Leu Ser Asp Asp Ile Pro Ala Arg Phe Ala

565 570 575

Asp Ser Asp Ala His Tyr Ala Phe Asp Tyr Tyr Ser Thr Ser Gly Asp 580. 585 590 Thr Leu Arg Leu Thr Asn Arg Pro Ile Ala Val Val Ile Asp Gly Asp 595 600 605

Val Asn Gly Arg Glu Gin Ser Lys Cys Arg Phe Met Glu Gly Ser Pro

610 615 620

Ser Thr Ala Pro His Arg Val Cys Glu Gin Tyr Leu Pro Gly Glu Ser 625 630 635 640

Tyr Ala Tyr Leu Cys Leu Gly Phe Asn Arg Arg Leu Cys Gly Leu Val

645 650 655

Val Phe Pro Gly Gly Phe Ala Phe Thr Ile Asn Thr Ala Ala Tyr Leu 660 665 670 Ser Leu Ala Asp Pro Val Ala Arg Ala Val Gly Leu Arg Phe Cys Arg 675 680 685

Gly Ala Ala Thr Gly Pro Gly Leu Val Arg 690 695

(2) INFORMATION FOR SEQ ID NO: 233:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 423 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:233:

Val Pro Glu Gly Ala Trp Val Gly Gly Ala Cys Ala Arg Pro Arg Gly 1 5 10 15

Pro Arg Ala His Val Arg Leu Tyr Ala Val Cys Phe Val Cys Pro Gin

20 25 30

Gly Ile Arg Gly Gin Asp Phe Asn Leu Leu Phe Val Asp Glu Ala Asn 35 40 45 Phe Ile Arg Pro Asp Ala Val Gin Thr Ile Met Gly Phe Leu Asn Gin 50 55 60

Ala Asn Cys Lys Ile Ile Phe Val Ser Ser Thr Asn Thr Gly Lys Ala 65 70 75 80

Ser Thr Ser Phe Leu Tyr Asn Leu Arg Gly Ala Ala Asp Glu Leu Leu 85 90 95

Asn Val Val Thr Tyr Ile Cys Asp Asp His Met Pro Arg Val Val Thr

100 105 110

His Thr Asn Ala Thr Ala Cys Ser Cys Tyr Ile Leu Asn Lys Pro Val 115 120 125 Phe Ile Thr Met Asp Gly Ala Val Arg Arg Thr Ala Asp Leu Phe Leu 130 135 140

Pro Asp Ser Phe Met Gin Glu Ile Ile Gly Gly Gin Ala Arg Glu Thr 145 150 155 160

Gly Asp Asp Arg Pro Val Leu Thr Lys Ser Ala Gly Glu Arg Phe Leu 165 170 175

Leu Tyr Arg Pro Ser Thr Thr Thr Asn Ser Gly Leu Met Ala Pro Glu

180 185 190

Leu Tyr Val Tyr Val Asp Pro Ala Phe Thr Ala Asn Thr Arg Ala Ser 195 200 205 Gly Thr Gly Ile Ala Val Val Gly Arg Tyr Arg Asp Asp Phe Ile lie 210 215 220

Phe Ala Leu Glu His Phe Phe Leu Arg Ala Leu Thr Gly Ser Ala Pro 225 230 235 240

Ala Asp Ile Ala Arg Cys Val Val His Ser Leu Ala Gin Val Leu Ala 245 250 255

Leu His Pro Gly Ala Phe Arg Ser Val Arg Val Ala Val Glu Gly Asn

260 265 270

Ser Ser Gin Asp Ser Ala Val Ala Ile Ala Thr His Val His Thr Glu 275 280 285 Met His Arg Ile Leu Ala Ser Ala Gly Ala Asn Gly Pro Gly Pro Glu 290 295 300

Leu Leu Phe Tyr His Cys Glu Pro Pro Gly Gly Ala Val Leu Tyr Pro 305 310 315 320 Phe Phe Leu Leu Asn Lys Gin Lys Thr Pro Ala Phe Glu Tyr Phe Ile

325 330 335

Lys Lys Phe Asn Ser Gly Gly Val Met Ala Ser Gin Glu Leu Val Ser

340 345 350

Val Thr Val Arg Leu Gin Thr Asp Pro Val Glu Tyr Leu Ser Glu Gin

355 360 365

Leu Asn Asn Leu Ile Glu Thr Val Ser Pro Asn Thr Asp Val Arg Met

370 375 380

Tyr Ser Gly Lys Arg Asn Gly Ala Ala Asp Asp Leu Met Val Ala Val 385 390 395 400 lie Met Ala Ile Tyr Leu Ala Ala Pro Thr Gly Ile Pro Pro Ala Phe

405 410 415

Phe Pro Ile Thr Arg Thr Ser 420

(2) INFORMATION FOR SEQ ID NO: 234:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 312 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 234:

Met Ile Thr Asp Cys Phe Glu Ala Asp Ile Ala Ile Pro Ser Gly Ile 1 5 10 15 Ser Arg Pro Asp Ala Ala Ala Leu Gin Arg Cys Glu Gly Arg Val Val 20 25 30

Phe Leu Pro Thr Ile Arg Arg Gin Leu Ala Asp Val Ala His Glu Ser

35 40 45

Phe Val Ser Gly Gly Val Ser Pro Asp Thr Leu Gly Leu Leu Leu Ala 50 55 60

Tyr Arg Arg Arg Phe Pro Ala Val Ile Thr Arg Val Leu Pro Thr Arg 65 70 75 80

Ile Val Ala Cys Pro Val Asp Leu Gly Leu Thr His Ala Gly Thr Val 85 90 95 Asn Leu Arg Asn Thr Ser Pro Val Asp Leu Cys Asn Gly Asp Pro Val 100 105 110

Ser Leu Val Pro Pro Val Phe Glu Gly Gin Ala Thr Asp Val Arg Leu 115 120 125 Glu Ser Leu Asp Leu Thr Leu Arg Phe Pro Val Pro Leu Pro Thr Pro

130 135 140

Leu Ala Arg Glu Ile Val Ala-Arg Leu Val Arg Ile Arg Asp Leu Asn 145 150 155 160 Pro Asp Pro Arg Thr Pro Gly Glu Leu Pro Asp Leu Asn Val Leu Tyr

165 170 175 Tyr Asn Gly Ala Arg Leu Ser Leu Val Ala Asp Val Gin Gin Leu Ala 180 185 190

Ser Val Asn Thr Glu Leu Arg Ser Leu Val Leu Asn Met Val Tyr Ser 195 200 205

Ile Thr Glu Gly Thr Thr Leu Ile Leu Thr Leu Ile Pro Arg Leu Leu

210 215 220

Ala Leu Ser Ala Gin Asp Gly Tyr Val Asn Ala Leu Leu Gin Met Gin 225 230 235 240 Ser Val Thr Arg Glu Ala Ala Gin Leu Ile His Pro Glu Ala Pro Met

245 250 255 Leu Met Gin Asp Gly Glu Arg Arg Leu Pro Leu Tyr Glu Ala Leu Val 260 265 270

Ala Trp Leu Ala His Ala Gly Gin Leu Gly Asp Ile Leu Ala Pro Ala 275 280 285

Val Arg Val Cys Thr Phe Asp Gly Ala Ala Val Val Gin Ser Gly Asp

290 295 300

Met Ala Pro Val Ile Arg Tyr Pro 305 310

(2) INFORMATION FOR SEQ ID NO: 235:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 222 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 235:

Met Thr Met Arg Asp Asp Val Pro Leu Leu Asp Arg Glu Leu Val Tyr 1 5 10 15 Glu Ala Ala Cys Gly Gly Glu Asp Gly Glu Leu Pro Leu Asp Glu Gin 20 25 30

Phe Ser Leu Ser Ser Tyr Gly Thr Ser Asp Phe Phe Val Ser Ser Ala 35 40 45 Tyr Ser Arg Leu Pro Pro His Thr Gin Pro Val Phe Ser Lys Arg Val

50 55 60

Val Met Phe Ala Trp Ser Phe -Leu Val Leu Lys Pro Leu Glu Leu Val 65 70 75 80 Ala Ala Gly Met Tyr Tyr Gly Trp Thr Gly Arg Ala Val Ala Pro Ala

85 90 95

Cys Ile Ile Ala Ala Val Leu Ala Tyr Tyr Val Thr Trp Leu Ala Arg

100 105 110

Ala Leu Leu Leu Tyr Val Asn Ile Lys Arg Asp Arg Leu Pro Leu Ser 115 120 125

Pro Pro Val Phe Trp Gly Leu Cys Val Ile Met Gly Gly Ala Ala Leu

130 135 140

Cys Ala Leu Val Ala Ala Ala His Glu Thr Phe Ser Pro Asp Gly Leu 145 150 155 160 Phe His Trp Ile Thr Ala Ser Gin Leu Leu Pro Arg Thr Asp Pro Leu

165 170 175

Arg Ala Arg Ser Leu Gly Ile Ala Cys Ala Ala Gly Ala Ala Met Trp

180 185 190

Val Ala Ala Ala Asp Cys Phe Ala Ala Phe Thr Asn Phe Phe Leu Ala 195 200 205

Arg Phe Trp Thr Arg Ala Ile Leu Lys Ala Pro Val Ala Phe 210 215 220

(2) INFORMATION FOR SEQ ID NO: 236:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 824 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 236:

Met Gly Pro Gly Leu Trp Val Val Met Gly Val Leu Val Gly Val Ala

1 5 10 15

Gly Gly His Asp Thr Tyr Trp Thr Glu Gin Ile Asp Pro Trp Phe Leu 20 25 30 His Gly Leu Gly Leu Ala Arg Thr Tyr Trp Arg Asp Thr Asn Thr Gly 35 40 45

Arg Leu Trp Leu Pro Asn Thr Pro Asp Ala Ser Asp Pro Gin Arg Gly 50 55 60 Arg Leu Ala Pro Pro Gly Glu Leu Asn Leu Thr Thr Ala Ser Val Pro 65 70 75 80

Met Leu Arg Trp Tyr Ala Glu Arg Phe Cys Phe Val Leu Val Thr Thr 85 90 95 Ala Glu Phe Pro Arg Asp Pro Gly Gin Leu Leu Tyr Ile Pro Lys Thr 100 105 110

Tyr Leu Leu Gly Arg Pro Arg Asn Ala Ser Leu Pro Glu Leu Pro Glu

115 120 125

Ala Gly Pro Thr Ser Arg Pro Pro Ala Glu Val Thr Gin Leu Lys Gly 130 135 140

Leu Ser His Asn Pro Gly Ala Ser Ala Leu Leu Arg Ser Arg Ala Trp

145 150 155 160

Val Thr Phe Ala Ala Ala Pro Asp Arg Glu Gly Leu Thr Phe Pro Arg

165 170 175 Gly Asp Asp Gly Ala Thr Glu Arg His Pro Asp Gly Arg Arg Asn Ala

180 185 190

Pro Pro Pro Gly Pro Pro Ala Gly Thr Pro Arg His Pro Thr Thr Asn

195 200 205

Leu Ser Ile Ala His Leu His Asn Ala Ser Val Thr Trp Leu Ala Arg 210 215 220

Leu Leu Arg Thr Pro Gly Arg Tyr Val Tyr Leu Ser Pro Ser Ala Ser

225 230 235 240

Thr Trp Pro Val Gly Val Trp Thr Thr Gly Gly Leu Ala Phe Gly Cys

245 250 255 Asp Ala Ala Leu Val Arg Ala Arg Tyr Gly Lys Gly Phe Met Gly Leu

260 265 270

Val Ile Ser Met Arg Asp Ser Pro Pro Ala Glu Ile Ile Val Val Pro

275 280 285

Ala Asp Lys Thr Leu Ala Arg Val Gly Asn Pro Thr Asp Glu Asn Ala 290 295 300

Pro Ala Val Leu Pro Gly Pro Pro Ala Gly Pro Arg Tyr Arg Val Phe

305 310 315 320

Val Leu Gly Ala Pro Thr Pro Ala Asp Asn Gly Ser Ala Leu Asp Ala

325 330 335 Leu Arg Arg Val Ala Gly Tyr Pro Glu Glu Ser Thr Asn Tyr Ala Gin

340 345 350

Tyr Met Ser Arg Ala Tyr Ala Glu Phe Leu Gly Glu Asp Pro Gly Ser

355 360 365

Gly Thr Asp Ala Arg Pro Ser Leu Phe Trp Arg Leu Ala Gly Leu Leu 370 375 380

Ala Ser Ser Gly Phe Ala Phe Val Asn Ala Ala His Ala His Asp Ala 385 390 395 400

Ile Arg Leu Ser Asp Leu Leu Gly Phe Leu Ala His Ser Arg Val Leu 405 410 415

Ala Gly Leu Ala Arg Ala Ala Gly Cys Ala Ala Asp Ser Val Phe Leu

420 425 430

Asn Val Ser Val Leu Asp Pro Ala Ala Arg Leu Arg Leu Glu Ala Arg 435 440 445

Leu Gly His Leu Val Ala Ala Ile Arg Glu Gin Ser Leu Ala Ala His

450 455 460

Ala Leu Gly Tyr Gin Leu Ala Phe Val Leu Asp Ser Pro Ala Ala Tyr 465 470 475 480 Gly Ala Val Ala Pro Ser Ala Ala Arg Leu Ile Asp Ala Leu Tyr Ala

485 490 495

Glu Phe Leu Gly Gly Arg Ala Leu Thr Ala Pro Met Val Arg Arg Ala

500 505 510

Leu Phe Tyr Ala Thr Ala Val Leu Arg Ala Pro Phe Leu Ala Gly Ala 515 520 525

Pro Ser Ala Glu Gin Arg Glu Arg Ala Arg Arg Gly Leu Leu Ile Thr

530 535 540

Thr Ala Leu Cys Thr Ser Asp Val Ala Ala Ala Thr His Ala Asp Leu 545 550 555 560 Arg Ala Ala Arg Thr Asp His Gin Lys Asn Leu Phe Trp Leu Pro Asp

565 570 575

His Phe Ser Pro Cys Ala Ala Ser Leu Arg Phe Asp Leu Ala Glu Gly

580 585 590

Gly Phe Ile Leu Asp Ala Met Ala Thr Arg Ser Asp Ile Pro Ala Asp 595 600 605

Val Met Ala Gin Gin Thr Arg Gly Val Ala Ser Val Leu Thr Arg Trp

610 615 620

Ala His Tyr Asn Ala Leu Ile Arg Ala Phe Val Pro Glu Ala Thr His 625 630 635 640 Gin Cys Ser Gly Pro Ser His Asn Ala Glu Pro Arg Ile Leu Val Pro

645 650 655

Ile Thr His Asn Ala Ser Tyr Val Val Thr His Thr Pro Leu Pro Arg

660 665 670

Gly Ile Gly Tyr Lys Leu Thr Gly Val Asp Val Arg Arg Pro Leu Phe 675 680 685

Ile Thr Tyr Leu Thr Ala Thr Cys Glu Gly His Ala Arg Glu Ile Glu

690 695 700

Pro Lys Arg Leu Val Arg Thr Glu Asn Arg Arg Asp Leu Gly Leu Val 705 710 715 720 Gly Ala Val Phe Leu Arg Tyr Thr Pro Ala Gly Glu Val Met Ser Val

725 730 735

Leu Leu Val Asp Thr Asp Ala Thr Gin Gin Gin Leu Ala Gin Gly Pro 740 745 750 Val Ala Gly Thr Pro Asn Val Phe Ser Ser Asp Val Pro Ser Val Leu

755 760 765

Leu Phe Pro Asn Gly Thr Val Ile His Leu Leu Ala Phe Asp Thr Leu

770 775 780 Pro Ile Ala Thr Ile Ala Pro Gly Phe Leu Ala Ala Ser Ala Leu Gly

785 790 795 800

Val Val Met Ile Thr Ala Ala Gly lie Leu Arg Val Val Arg Thr Cys

805 810 815

Val Pro Phe Leu Trp Arg Arg Glu 820

(2) INFORMATION FOR SEQ ID NO: 237:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 370 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 237:

Met Ala Ser His Ala Gly Gin Gin His Ala Pro Ala Phe Gly Gin Ala 1 5 10 15

Ala Arg Ala Ser Gly Pro Thr Asp Gly Arg Ala Ala Ser Arg Pro Ser

20 25 30

His Arg Gin Gly Ala Ser Asp Pro Glu Leu Pro Thr Leu Leu Arg Val 35 40 45 Tyr Ile Asp Gly Pro His Gly Val Gly Lys Thr Thr Thr Ser Ala Gin 50 55 60

Leu Met Glu Ala Leu Gly Pro Arg Asp Asn Ile Val Tyr Val Pro Glu 65 70 75 80

Pro Met Thr Tyr Trp Gin Val Leu Gly Ala Ser Glu Thr Leu Thr Asn 85 90 95

Ile Tyr Asn Thr Gin His Arg Leu Asp Arg Gly Glu Ile Ser Ala Gly

100 105 110

Glu Ala Ala Val Val Met Thr Ser Ala Gin Ile Thr Met Ser Thr Pro 115 120 125 Tyr Ala Ala Thr Asp Ala Val Leu Ala Pro His Ile Gly Gly Glu Ala 130 135 140

Val Gly Pro Gin Ala Pro Pro Pro Ala Leu Thr Leu Val Phe Asp Arg 145 150 155 160 His Pro Ile Ala Ser Leu Leu Cys Tyr Pro Ala Ala Arg Tyr Leu Met

165 170 175

Gly Ser Met Thr Pro Gin Ala Val Leu Ala Phe Val Met Pro Pro Thr 180 185 190 Ala Pro Gly Thr Asn Leu Val Leu Gly Val Leu Pro Glu Ala Glu His 195 200 205

Ala Asp Arg Leu Ala Arg Arg Gin Arg Pro Gly Glu Arg Leu Asp Leu

210 215 220

Ala Met Leu Ser Ala Ile Arg Arg Val Tyr Asp Leu Leu Ala Asn Thr 225 230 235 240

Val Arg Tyr Leu Gin Arg Gly Gly Arg Trp Arg Glu Asp Trp Gly Arg

245 250 255

Leu Thr Gly Val Ala Ala Ala Thr Pro Arg Pro Asp Pro Glu Asp Gly 260 265 270 Ala Gly Ser Leu Pro Arg Ile Glu Asp Thr Leu Phe Ala Leu Phe Arg 275 280 285

Val Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu Tyr His Ile Phe Ala

290 295 300

Trp Val Leu Asp Val Leu Ala Asp Arg Leu Leu Pro Met His Leu Phe 305 310 315 320

Val Leu Asp Tyr Asp Gin Ser Pro Val Gly Cys Arg Asp Ala Leu Leu

325 330 335

Arg Leu Thr Ala Gly Met Ile Pro Thr Arg Val Thr Thr Ala Gly Ser 340 345 350 Ile Ala Glu Ile Arg Asp Leu Ala Arg Thr Phe Ala Arg Glu Val Gly 355 360 365

Gly Val 370

(2) INFORMATION FOR SEQ ID NO: 238:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 279 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:238:

Met Ala Arg Thr Gly Arg Arg Ala Ala Val Gly Arg Pro Ala Arg Thr 1 5 10 15 Ser Ser Leu Thr Glu Arg Arg Arg Val Leu Leu Ala Gly Val Arg Ser

20 25 30

His Thr Arg Phe Tyr Lys Ala Phe Ala Arg Glu Val Arg Glu Phe Asn 35 40 45 Ala Thr Arg Ile Cys Gly Thr Leu Leu Thr Leu Met Ser Gly Ser Leu 50 55 60

Gin Gly Arg Ser Leu Phe Glu Ala Thr Arg Val Thr Leu lie Cys Glu 65 70 75 80

Val Asp Leu Gly Pro Arg Arg Pro Asp Cys Ile Cys Val Phe Glu Phe 85 90 95

Ala Asn Asp Lys Thr Leu Gly Gly Val Cys Val Ile Leu Lys Thr Cys

100 105 110

Lys Ser Ile Ser Ser Gly Asp Thr Ala Ser Lys Arg Glu Gin Arg Thr 115 120 125 Thr Gly Met Lys Gin Leu Arg His Ser Leu Lys Leu Leu Gin Ser Leu 130 135 140

Ala Pro Pro Gly Asp Lys Val Val Tyr Leu Cys Pro Ile Leu Val Phe 145 150 155 160

Val Ala Gin Arg Thr Leu Arg Val Ser Arg Val Thr Arg Leu Val Pro 165 170 175

Gin Lys Ile Ser Gly Asn Ile Thr Ala Ala Val Arg Met Leu Gin Ser

180 185 190

Leu Ser Thr Tyr Ala Val Pro Pro Glu Pro Gin Thr Arg Arg Ser Arg 195 200 205 Arg Arg Val Ala Ala Thr Ala Arg Pro Gin Arg Pro Pro Ser Pro Thr 210 215 220

Arg Asp Pro Glu Gly Thr Ala Gly His Pro Ala Pro Pro Glu Ser Asp 225 230 235 240

Pro Pro Ser Pro Gly Val Val Gly Val Ala Ala Glu Gly Gly Gly Val 245 250 255

Leu Gin Lys Ile Ala Ala Leu Phe Cys Val Pro Val Ala Ala Lys Ser

260 265 270

Arg Pro Arg Thr Lys Thr Glu 275

(2) INFORMATION FOR SEQ ID NO: 239:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 571 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:239:

Met Asp Pro Tyr Tyr Pro Phe Asp Ala Leu Asp Val Trp Glu His Arg 1 5 10 15

Arg Phe Ile Val Ala Asp Ser Arg Ser Phe Ile Thr Pro Glu Phe Pro

20 25 30

Arg Asp Phe Trp Met Leu Pro Val Phe Asn Ile Pro Arg Glu Thr Ala 35 40 45

Ala Glu Arg Ala Ala Val Leu Gin Ala Gin Arg Thr Ala Ala Ala Ala

50 55 60

Ala Leu Glu Asn Ala Ala Leu Gin Ala Ala Glu Leu Pro Val Asp Ile 65 70 75 80 Glu Arg Arg Ile Arg Pro Ile Glu Gin Gin Val His His Ile Ala Asp

85 90 95

Ala Leu Glu Ala Leu Glu Thr Ala Ala Ala Ala Ala Glu Glu Ala Asp

100 105 110

Ala Ala Arg Asp Ala Glu Arg Glu Gly Ala Ala Asp Gly Ala Ala Pro 115 120 125

Ser Pro Thr Ala Gly Pro Ala Ala Ala Glu Met Glu Val Gin Ile Val

130 135 140

Arg Asn Asp Pro Pro Leu Arg Tyr Asp Thr Asn Leu Pro Val Asp Leu 145 150 155 160 Leu His Met Val Tyr Ala Gly Arg Gly Ala Ala Gly Ser Ser Gly Val

165 170 175

Val Phe Gly Thr Trp Tyr Arg Thr Ile Gin Glu Arg Thr Ile Ala Asp

180 185 190

Phe Pro Leu Thr Thr Arg Ser Ala Asp Phe Arg Asp Gly Arg Met Ser 195 200 205

Lys Thr Phe Met Thr Ala Leu Val Leu Ser Leu Gin Ser Cys Gly Arg

210 215 220

Leu Tyr Val Gly Gin Arg His Tyr Ser Ala Phe Glu Cys Ala Val Leu 225 230 235 240 Cys Leu Tyr Leu Leu Tyr Arg Thr Thr His Glu Ser Ser Pro Asp Arg

245 250 255

Asp Arg Ala Pro Val Ala Phe Gly Asp Leu Leu Ala Arg Leu Pro Arg

260 265 270

Tyr Leu Ala Arg Leu Ala Ala Val Ile Gly Asp Glu Ser Gly Arg Pro 275 280 285

Gin Tyr Arg Tyr Arg Asp Asp Lys Leu Pro Lys Ala Gin Phe Ala Ala

290 295 300

Ala Gly Gly Arg Tyr Glu His Gly Ala Thr His Val Val Ile Ala Thr 305 310 315 320

Leu Val Arg His Gly Val Leu Pro Ala Ala Pro Gly Asp Val Pro Arg

325 330 335

Asp Thr Ser Thr Arg Val Asn Pro Asp Asp Val Ala His Arg Asp Asp 340 345 350

Val Asn Arg Ala Ala Ala Ala Phe Leu Arg His Asn Leu Phe Leu Trp

355 360 365

Glu Asp Gin Thr Leu Leu Arg Ala Thr Ala Asn Thr Ile Thr Ala Val

370 375 380 Leu Arg Arg Leu Leu Ala Asn Gly Asn Val Tyr Ala Asp Arg Leu Asp

385 390 395 400

Asn Arg Leu Gin Leu Gly Met Leu Ile Pro Gly Ala Val Pro Ala Glu

405 410 415

Ala Ile Arg Ala Ser Gly Leu Asp Ser Gly Ala Ile Lys Ser Gly Asp 420 425 430

Asn Asn Leu Glu Ala Leu Cys Val Asn Tyr Val Leu Pro Leu Tyr Gin

435 440 445

Ala Asp Pro Thr Val Glu Leu Thr Gin Leu Phe Pro Gly Leu Ala Ala

450 455 460 Leu Cys Leu Asp Ala Gin Ala Gly Arg Pro Leu Ala Ser Thr Arg Arg

465 470 475 480

Val Val Asp Met Ser Ser Gly Ala Arg Gin Ala Ala Leu Val Arg Leu

485 490 495

Thr Ala Leu Glu Leu Ile Asn Arg Thr Arg Thr Asn Thr Thr Pro Val 500 505 510

Gly Glu Ile Ile Asn Ala His Asp Ala Leu Gly Ile Gin Tyr Glu Gin

515 520 525

Gly Leu Gly Leu Leu Ala Gin Gin Ala Arg Ile Gin Ala Lys Arg Phe 530 535 540 Ala Thr Phe Asn Val Gly Ser Asp Tyr Asp Leu Leu Tyr Phe Leu Cys 545 550 555 560

Leu Gly Phe Ile Pro Gin Tyr Leu Ser Val Ala 565 570

(2) INFORMATION FOR SEQ ID NO: 240:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 651 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 240:

Met Ala Ser Ala Glu Met Arg Glu Arg Leu Glu Ala Pro Leu Pro Asp 1 5 10 15

Arg Ala Val Pro Ile Tyr Val Ala Gly Phe Leu Ala Leu Tyr Asp Ser

20 25 30

Gly Asp Pro Gly Glu Leu Ala Leu Asp Pro Asp Thr Val Arg Ala Ala 35 40 45 Leu Pro Pro Glu Asn Pro Leu Pro Ile Asn Val Asp His Arg Ala Arg 50 55 60

Cys Glu Val Gly Arg Val Leu Ala Val Val Asn Asp Pro Arg Gly Pro 65 70 75 80

Phe Phe Val Gly Leu Ile Ala Cys Val Gin Leu Glu Arg Val Leu Glu 85 90 95

Thr Ala Ala Ser Ala Ala Ile Phe Glu Arg Arg Gly Pro Ala Leu Ser

100 105 110

Arg Glu Glu Arg Leu Leu Tyr Leu Ile Thr Asn Tyr Leu Pro Ser Val 115 120 125 Ser Leu Ser Thr Lys Arg Arg Gly Asp Glu Val Pro Pro Asp Arg Thr 130 135 140

Leu Phe Ala His Val Cys Ala Ile Gly Arg Arg Leu Gly Thr Ile Val 145 150 155 160

Thr Tyr Asp Thr Ser Leu Asp Ala Ala Ile Ala Pro Phe Arg His Leu 165 170 175

Asp Pro Ala Thr Arg Glu Gly Val Arg Arg Glu Ala Ala Glu Ala Glu

180 185 190

Leu Ala Gly Arg Thr Trp Ala Pro Gly Val Glu Ala Leu Thr His Thr 195 200 205 Leu Leu Ser Thr Ala Val Asn Asn Met Met Leu Arg Asp Arg Trp Ser 210 215 220

Leu Val Ala Glu Arg Arg Arg Gin Ala Gly Ile Ala Gly His Thr Tyr 225 230 235 240

Leu Gin Ala Ser Glu Lys Phe Lys Ile Trp Gly Ala Glu Ser Ala Pro 245 250 255

Ala Pro Glu Arg Gly Tyr Lys Thr Gly Ala Pro Gly Ala Met Asp Thr

260 265 270

Ser Pro Ala Ala Ser Val Pro Ala Pro Gin Val Ala Val Arg Ala Arg 275 280 285 Gin Val Ala Ser Ser Ser Ser Ser Ser Ser Ser Phe Pro Ala Pro Ala 290 295 300

Asp Met Asn Pro Val Ser Ala Ser Gly Ala Pro Ala Pro Pro Pro Pro 305 310 315 320 Gly Asp Gly Ser Tyr Leu Trp Ile Pro Ala Phe His Tyr Asn Gin Leu

325 330 335

Val Thr Gly Gin Ser Ala Pro His His Pro Pro Leu Thr Ala Cys Gly 340 345 350 Leu Pro Ala Ala Gly Thr Val Ala Tyr Gly His Pro Gly Ala Gly Pro 355 360 365

Ser Pro His Tyr Pro Pro Pro Pro Ala His Pro Tyr Pro Gly Met Leu

370 375 380

Phe Ala Gly Pro Ser Pro Leu Glu Ala Gin Ile Ala Ala Leu Val Gly 385 390 395 400

Ala Ile Ala Ala Asp Arg Gin Ala Gly Gly Leu Pro Ala Ala Ala Gly

405 410 415

Asp His Gly Ile Arg Gly Ser Ala Lys Arg Arg Arg His Glu Val Glu 420 425 430 Gin Pro Glu Tyr Asp Cys Gly Arg Asp Glu Pro Asp Arg Asp Phe Pro 435 440 445

Tyr Tyr Pro Gly Glu Ala Arg Pro Glu Pro Arg Pro Val Asp Ser Arg

450 455 460

Arg Ala Ala Arg Gin Ala Ser Gly Phe Thr Ile Thr Ala Leu Val Gly 465 470 475 480

Ala Val Thr Ser Leu Gin Gin Glu Leu Ala His Met Arg Ala Arg Thr

485 490 495

His Ala Pro Tyr Gly Pro Tyr Pro Pro Val Gly Pro Tyr His His Pro 500 505 510 His Ala Asp Thr Glu Thr Pro Ala Gin Pro Pro Arg Tyr Pro Ala Glu 515 520 525

Ala Val Tyr Leu Pro Pro Pro His Ile Ala Pro Pro Gly Pro Pro Leu

530 535 540

Ser Gly Ala Val Pro Pro Pro Ser Tyr Pro Pro Val Ala Val Thr Pro 545 550 555 560

Gly Pro Ala Pro Pro Leu His Gin Pro Ser Pro Ala His Ala His Pro

565 570 575

Pro Pro Pro Pro Pro Gly Pro Thr Pro Pro Pro Ala Ala Ser Leu Pro 580 585 590 Gin Pro Glu Ala Pro Gly Ala Glu Ala Gly Ala Leu Val Asn Ala Ser 595 600 605

Ser Ala Ala His Val Lys Arg Gly His Gly Pro Gly Arg Arg Ser Val

610 615 620

Cys Val Thr Asp Asp Gly Val Pro Leu Thr Arg Leu Gin Asp Pro Asp 625 630 635 640

Leu Gly Gly Val Cys Val Phe Ile Tyr Phe Lys 645 650 (2) INFORMATION FOR SEQ ID NO : 241:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 896 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:241:

Met Arg Gly Gly Gly Leu Ile Cys Ala Leu Val Val Gly Ala Leu Val 1 5 10 15 Ala Ala Val Ala Ser Ala Ala Pro Ala Ala Pro Ala Ala Pro Arg Ala 20 25 30

Ser Gly Gly Val Ala Ala Thr Val Ala Ala Asn Gly Gly Pro Ala Ser

35 40 45

Arg Pro Pro Pro Val Pro Ser Pro Ala Thr Thr Lys Ala Arg Lys Arg 50 55 60

Lys Thr Lys Lys Pro Pro Lys Arg Pro Glu Ala Thr Pro Pro Pro Asp 65 70 75 80

Ala Asn Ala Thr Val Ala Ala Gly His Ala Thr Leu Arg Ala His Leu 85 90 95 Arg Glu Ile Lys Val Glu Asn Ala Asp Ala Gin Phe Tyr Val Cys Pro 100 105 110

Pro Pro Thr Gly Ala Thr Val Val Gin Phe Glu Gin Pro Arg Arg Cys

115 120 125

Pro Trp Glu Gly Gin Asn Tyr Thr Glu Gly Ile Ala Val Val Phe Lys 130 135 140

Glu Asn Ile Ala Pro Tyr Lys Phe Lys Ala Thr Met Tyr Tyr Lys Asp

145 150 155 160

Val Thr Val Ser Gin Val Trp Phe Gly His Arg Tyr Ser Gin Phe Met

165 170 175 Gly Ile Phe Glu Asp Arg Ala Pro Val Pro Phe Glu Glu Val Ile Asp

180 185 190

Lys Ile Asn Ala Lys Gly Val Cys Arg Ser Thr Ala Lys Tyr Val Arg

195 200 205

Asn Asn Met Thr Ala Phe His Arg Asp Asp His Glu Thr Asp Met Glu 210 215 220

Leu Lys Pro Ala Lys Val Ala Thr Arg Thr Ser Arg Gly Trp His Thr 225 230 235 240

Thr Asp Leu Lys Tyr Asn Pro Ser Arg Val Glu Ala Phe His Arg Tyr 245 250 255

Gly Thr Thr Val Asn Cys Ile Val Glu Glu Val Asp Ala Arg Ser Val

260 265 270

Tyr Pro Tyr Asp Glu Phe Val Leu Ala Thr Gly Asp Phe Val Tyr Met 275 280 285

Ser Pro Phe Tyr Gly Tyr Arg Glu Gly Ser His Thr Glu His Thr Ser

290 295 300

Tyr Ala Ala Asp Arg Phe Lys Gin Val Asp Gly Phe Tyr Ala Arg Asp 305 310 315 320 Leu Thr Thr Lys Ala Arg Ala Thr Ser Pro Thr Thr Arg Asn Leu Leu

325 330 335

Thr Thr Pro Lys Phe Thr Val Ala Trp Asp Trp Val Pro Lys Arg Pro

340 345 350

Ala Val Cys Thr Met Thr Lys Trp Gin Glu Val Asp Glu Met Leu Arg 355 360 365

Ala Glu Tyr Gly Gly Ser Phe Arg Phe Ser Ser Asp Ala Ile Ser Thr

370 375 380

Thr Phe Thr Thr Asn Leu Thr Gin Tyr Ser Leu Ser Arg Val Asp Leu 385 390 395 400 Gly Asp Cys Ile Gly Arg Asp Ala Arg Glu Ala Ile Asp Arg Met Phe

405 410 415

Ala Arg Lys Tyr Asn Ala Thr His Ile Lys Val Gly Gin Pro Gin Tyr

420 425 430

Tyr Leu Ala Thr Gly Gly Phe Leu Ile Ala Tyr Gin Pro Leu Leu Ser 435 440 445

Asn Thr Leu Ala Glu Leu Tyr Val Arg Glu Tyr Met Arg Glu Gin Asp

450 455 460

Arg Lys Pro Arg Asn Ala Thr Pro Ala Pro Leu Arg Glu Ala Pro Ser 465 470 475 480 Ala Asn Ala Ser Val Glu Arg Ile Lys Thr Thr Ser Ser Ile Glu Phe

485 490 495

Ala Arg Leu Gin Phe Thr Tyr Asn His Ile Gin Arg His Val Asn Asp

500 505 510

Met Leu Gly Arg Ile Ala Val Ala Trp Cys Glu Leu Gin Asn His Glu 515 520 525

Leu Thr Leu Trp Asn Glu Ala Arg Lys Leu Asn Pro Asn Ala Ile Ala

530 535 540

Ser Ala Thr Val Gly Arg Arg Val Ser Ala Arg Met Leu Gly Asp Val 545 550 555 560 Met Ala Val Ser Thr Cys Val Pro Val Ala Pro Asp Asn Val Ile Val

565 570 575

Gin Asn Ser Met Arg Val Ser Ser Arg Pro Gly Thr Cys Arg Pro Leu 580 585 590 Val Ser Phe Arg Tyr Glu Asp Gin Gly Pro Leu Ile Glu Gly Gin Leu

595 600 605

Gly Glu Asn Asn Glu Leu Arg Leu Thr Arg Asp Ala Leu Glu Pro Cys

610 615 620 Thr Val Gly His Arg Arg Tyr Phe Ile Phe Gly Gly Gly Tyr Val Tyr

625 630 635 640

Phe Glu Glu Tyr Ala Tyr Ser His Gin Leu Ser Arg Ala Asp Val Thr

645 650 655

Thr Val Ser Thr Phe Ile Asp Leu Asn Ile Thr Met Leu Glu Asp His 660 665 670

Glu Phe Val Pro Leu Glu Val Tyr Thr Arg His Glu Ile Lys Asp Ser

675 680 685

Gly Leu Leu Asp Tyr Thr Glu Val Gin Arg Arg Asn Gin Leu His Asp

690 695 700 Leu Arg Phe Ala Asp Ile Asp Thr Val Ile Arg Ala Asp Ala Asn Ala

705 710 715 720

Ala Met Phe Ala Gly Leu Cys Ala Phe Phe Glu Gly Met Gly Asp Leu

725 730 735

Gly Arg Ala Val Gly Lys Val Val Met Gly Val Val Gly Gly Val Val 740 745 750

Ser Ala Val Ser Gly Val Ser Ser Phe Met Ser Asn Pro Phe Gly Ala

755 760 765

Val Gly Leu Leu Val Leu Ala Gly Leu Val Ala Ala Phe Phe Ala Phe

770 775 780 Arg Tyr Val Leu Gin Leu Gin Arg Asn Pro Met Lys Ala Leu Tyr Pro

785 790 795 800

Leu Thr Thr Lys Glu Leu Lys Thr Ser Asp Pro Gly Gly Val Gly Gly

805 810 815

Glu Gly Glu Glu Gly Ala Glu Gly Gly Gly Phe Asp Glu Ala Lys Leu 820 825 830

Ala Glu Ala Arg Glu Met Ile Arg Tyr Met Ala Leu Val Ser Ala Met

835 840 845

Glu Arg Thr Glu His Lys Ala Arg Lys Lys Gly Thr Ser Ala Leu Leu 850 855 860 Ser Ser Lys Val Thr Asn Met Val Leu Arg Lys Arg Asn Lys Ala Arg 865 870 875 880

Tyr Ser Pro Leu His Asn Glu Asp Glu Ala Gly Asp Glu Asp Glu Leu 885 890 895

(2) INFORMATION FOR SEQ ID NO: 242:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 69 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:242:

Val Val Ala Gly Leu Gly Thr Gly Gly Gly Arg Glu Ala Gly Pro Pro 1 5 10 15

Phe Ala Ala Thr Val Ala Ala Thr Pro Pro Glu Arg Ala Ala Gly Ala

20 25 30

Ala Gly Ala Ala Asp Ala Thr Ala Ala Thr Ser Ala Pro Thr Thr Ser 35 40 45 Ala Gin Ile Lys Pro Pro Pro Arg Met Ala Gly Leu Arg Gly Arg Val 50 55 60

Ala Pro Ala Ala Arg 65

(2) INFORMATION FOR SEQ ID NO: 243:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 773 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:243:

Met Ala Ala Ala Pro Pro Ala Ala Val Ser Glu Pro Thr Ala Ala Arg

1 5 10 15

Gin Lys Leu Leu Ala Leu Leu Gly Gin Val Gin Thr Tyr Val Phe Gin 20 25 30

Leu Glu Leu Leu Arg Arg Cys Asp Pro Gin Ile Gly Leu Gly Lys Leu

35 40 45

Ala Gin Leu Lys Leu Asn Ala Leu Gin Val Arg Val Leu Arg Arg His 50 55 60 Leu Arg Pro Gly Leu Glu Ala Gin Ala Ala Ala Phe Leu Thr Pro Leu 65 70 75 80

Ser Val Thr Leu Glu Leu Leu Leu Glu Tyr Ala Trp Arg Glu Gly Glu 85 90 95 Arg Leu Leu Gly His Leu Glu Thr Phe Ala Thr Thr Gly Asp Val Ser

100 105 110

Ala Phe Phe Thr Glu Thr Met Gly Leu Ala Arg Pro Cys Pro Tyr His 115 120 125 Gin Gin Ile Arg Leu Glu Thr Tyr Gly Gly Asp Val Arg Met Glu Leu 130 135 140

Cys Phe Leu His Asp Val Glu Asn Phe Leu Lys Gin Leu Asn Tyr Cys 145 150 155 160

His Leu Ile Thr Pro Pro Ser Gly Ala Thr Ala Ala Leu Glu Arg Val 165 170 175

Arg Glu Phe Met Val Ala Ala Val Gly Ser Gly Leu Ile Val Pro Pro

180 185 190

Glu Leu Ser Asp Pro Ser His Pro Cys Ala Val Cys Phe Glu Glu Leu 195 200 205 Cys Val Thr Ala Asn Gin Gly Ala Thr Ile Ala Arg Arg Leu Ala Asp 210 215 220

Arg Ile Cys Asn His Val Thr Gin Gin Ala Gin Val Arg Leu Asp Ala 225 230 235 240

Asn Glu Leu Arg Arg Tyr Leu Pro His Ala Ala Gly Leu Ser Asp Ala 245 250 255

Ala Arg Ala Arg Ala Leu Cys Val Leu Asp Gin Ala Arg Thr Ala Ala

260 265 270

Gly Gly Gly Ala Arg Ala Gly Pro Pro Pro Ala Asp Ser Ser Ser Val 275 280 285 Arg Glu Glu Ala Asp Ala Leu Leu Glu Ala His Asp Val Phe Gin Ala 290 295 300

Thr Thr Pro Gly Ala Ile Ser Glu Leu Arg Phe Trp Leu Ala Ser Gly 305 310 315 320

Asp Arg Ala Arg His Ser Thr Met Asp Ala Phe Ala Asp Asn Leu Asn 325 330 335

Ala Gin Arg Glu Leu Gin Gin Glu Thr Ala Ala Val Ala Val Glu Leu

340 345 350

Ala Leu Phe Gly Arg Arg Ala Glu His Phe Asp Arg Ala Phe Gly Gly 355 360 365 His Leu Ala Ala Leu Asp Met Val Asp Ala Leu Ile Ile Gly Gly Gin 370 375 380

Ala Thr Ser Pro Asp Asp Gin Ile Glu Ala Leu Ile Arg Ala Cys Tyr 385 390 395 400

Asp His His Leu Thr Thr Pro Leu Leu Arg Arg Leu Val Ser Pro Glu 405 410 415

Gin Cys Asp Glu Glu Ala Leu Arg Arg Val Leu Ala Arg Leu Gly Ala

420 425 430

Gly Gly Ala Thr Gly Gly Ala Glu Glu Glu Glu Pro Arg Ala Ala Ala 435 440 445

Glu Glu Gly Gly Arg Arg Arg Gly Ala Gly Thr Pro Ala Ser Glu Asp

450 455 460

Gly Glu Arg Gly Pro Glu Pro Gly Ala Gin Gly Pro Glu Ser Trp Gly 465 470 475 480

Asp Ile Ala Thr Arg Ala Ala Ala Asp Val Pro Glu Arg Arg Arg Leu

485 490 495

Tyr Ala Asp Arg Leu Thr Lys Arg Ser Leu Ala Ser Leu Gly Arg Cys 500 505 510 Val Arg Glu Gin Arg Gly Glu Leu Glu Lys Met Leu Arg Val Ser Val 515 520 525

His Gly Glu Val Leu Pro Ala Thr Phe Ala Ala Val Ala Asn Gly Phe

530 535 540

Ala Ala Arg Ala Arg Phe Cys Ala Leu Thr Ala Gly Ala Gly Thr Val 545 550 555 560

Ile Asp Asn Arg Ala Ala Pro Gly Val Phe Asp Ala His Arg Phe Met

565 570 575

Arg Ala Ser Leu Leu Arg His Gin Val Asp Pro Ala Leu Leu Pro Ser 580 585 590 Ile Thr Phe Phe Glu Leu Val Asn Gly Pro Leu Phe Asp His Ser Thr 595 600 605

His Ser Phe Ala Gin Pro Pro Asn Thr Ala Leu Tyr Tyr Ser Val Glu

610 615 620

Asn Val Gly Leu Leu Pro His Leu Lys Glu Glu Leu Ala Arg Phe Ile 625 630 635 640

Met Gly Ala Gly Gly Ser Gly Ala Asp Trp Ala Val Ser Glu Phe Gin

645 650 655

Lys Phe Tyr Cys Phe Asp Gly Val Ser Gly Ile Thr Pro Thr Gin Arg 660 665 670 Ala Ala Trp Arg Tyr Ile Arg Glu Leu Ile Ile Ala Thr Thr Leu Phe 675 680 685

Ala Ser Val Tyr Arg Cys Gly Glu Leu Glu Leu Arg Arg Pro Asp Cys

690 695 700

Ser Arg Pro Thr Ser Glu Gly Arg Tyr Pro Pro Gly Val Tyr Leu Thr 705 710 715 720

Tyr Asn Ser Asp Cys Pro Leu Val Ala Ile Val Glu Ser Gly Pro Asp

725 730 735

Gly Cys Ile Gly Pro Arg Ser Val Val Val Tyr Asp Arg Asp Val Phe 740 745 750 Ser lie Lys Val Leu Gin His Leu Ala Pro Arg Leu Ala Gly Gly Gly 755 760 765

Ser Asp Ala Pro Pro 770 (2) INFORMATION FOR SEQ ID NO: 244:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 616 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 244:

Met Asp Thr Lys Pro Lys Thr Thr Thr Thr Val Lys Val Pro Pro Gly 1 5 10 15

Pro Met Gly Tyr Val Tyr Gly Arg Ala Cys Pro Ala Glu Gly Leu Glu

20 25 30

Leu Leu Ser Leu Leu Ser Ala Arg Ser Gly Asp Ala Asp Val Ala Val 35 40 45 Ala Pro Leu Ile Val Gly Leu Thr Val Glu Ser Gly Phe Glu Ala Asn 50 55 60

Val Ala Ala Val Val Gly Ser Arg Thr Thr Gly Leu Gly Gly Thr Ala 65 70 75 80

Val Ser Leu Lys Leu Met Pro Ser His Tyr Ser Pro Ser Val Tyr Val 85 90 95

Phe His Gly Gly Arg His Leu Ala Pro Ser Thr Gin Ala Pro Asn Leu

100 105 110

Thr Arg Leu Cys Glu Arg Ala Arg Arg His Phe Gly Phe Ser Asp Tyr 115 120 125 Ala Pro Arg Pro Cys Asp Leu Lys His Glu Thr Thr Gly Asp Ala Leu 130 135 140

Cys Glu Arg Leu Gly Leu Asp Pro Asp Arg Ala Leu Leu Tyr Leu Val 145 150 155 160

Ile Thr Glu Gly Phe Arg Glu Ala Val Cys Ile Ser Asn Thr Phe Leu 165 170 175

His Leu Gly Gly Met Asp Lys Val Thr Ile Gly Asp Ala Glu Val His

180 185 190

Arg Ile Pro Val Tyr Pro Leu Gin Met Phe Met Pro Asp Phe Ser Arg 195 200 205 Val Ile Ala Asp Pro Phe Asn Cys Asn His Arg Ser Ile Gly Glu Asn 210 215 220

Phe Asn Tyr Pro Leu Pro Phe Phe Asn Arg Pro Leu Ala Arg Leu Leu 225 230 235 240 Phe Glu Ala Val Val Gly Pro Ala Ala Val Arg Ala Arg Asn Val Asp

245 250 255

Ala Val Ala Arg Ala Ala Ala His Leu Ala Phe Asp Glu Asn His Glu 260 265 270 Gly Ala Ala Leu Pro Ala Asp Ile Thr Phe Thr Ala Phe Glu Ala Ser 275 280 285

Gin Gly Lys Pro Gin Arg Gly Ala Arg Asp Ala Gly Asn Lys Gly Pro

290 295 300

Ala Gly Gly Phe Glu Gin Arg Leu Ala Ser Val Met Ala Gly Asp Ala 305 310 315 320

Ala Leu Glu Ser Ile Val Ser Met Ala Val Phe Asp Glu Pro Pro Pro

325 330 335

Asp Ile Thr Thr Trp Pro Leu Leu Glu Gly Gin Glu Thr Pro Ala Ala 340 345 350 Arg Ala Gly Ala Val Gly Ala Tyr Leu Ala Arg Ala Ala Gly Leu Val 355 360 365

Gly Ala Met Val Phe Ser Thr Asn Ser Ala Leu His Leu Thr Glu Val

370 375 380

Asp Asp Ala Gly Pro Ala Asp Pro Lys Asp His Ser Lys Pro Ser Phe 385 390 395 400

Tyr Arg Phe Phe Leu Val Pro Gly Thr His Val Ala Ala Asn Pro Gin

405 410 415

Leu Asp Arg Glu Gly His Val Val Pro Gly Tyr Glu Gly Arg Pro Thr 420 425 430 Ala Pro Leu Val Gly Gly Thr Gin Glu Phe Ala Gly Glu His Leu Ala 435 440 445

Met Leu Cys Gly Phe Ser Pro Ala Leu Leu Ala Lys Met Leu Phe Tyr

450 455 460

Leu Glu Arg Cys Asp Gly Gly Val Ile Val Gly Arg Gin Glu Met Asp 465 470 475 480

Val Phe Arg Tyr Val Ala Asp Ser Gly Gin Thr Asp Val Pro Cys Asn

485 490 495

Leu Cys Thr Phe Glu Thr Arg His Ala Cys Ala His Thr Thr Leu Met 500 505 510 Arg Leu Arg Ala Arg His Pro Lys Phe Ala Ser Ala Arg Ala Ile Gly 515 520 525

Val Phe Gly Thr Met Asn Ser Ala Tyr Ser Asp Cys Asp Val Leu Gly

530 535 540

Asn Tyr Ala Ala Phe Ser Ala Leu Lys Arg Ala Asp Gly Ser Glu Asn 545 550 555 560

Thr Arg Thr Ile Met Gin Glu Tyr Ala Ala Thr Glu Arg Val Met Ala

565 570 575

Glu Leu Glu Ala Leu Gin Tyr Val Asp Gin Ala Val Pro Thr Ala Leu 580 585 590

Gly Arg Leu Glu Thr Ile Ile Gly Thr Arg Glu Ala Leu His Thr Val

595 600 605

Val Asn Asn Ile Lys Gin Leu Val 610 615

(2) INFORMATION FOR SEQ ID NO: 245:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 616 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 245:

Met Asp Thr Lys Pro Lys Thr Thr Thr Thr Val Lys Val Pro Pro Gly 1 5 10 15

Pro Met Gly Tyr Val Tyr Gly Arg Ala Cys Pro Ala Glu Gly Leu Glu

20 25 30

Leu Leu Ser Leu Leu Ser Ala Arg Ser Gly Asp Ala Asp Val Ala Val 35 40 45 Ala Pro Leu Ile Val Gly Leu Thr Val Glu Ser Gly Phe Glu Ala Asn 50 55 60

Val Ala Ala Val Val Gly Ser Arg Thr Thr Gly Leu Gly Gly Thr Ala 65 70 75 80

Val Ser Leu Lys Leu Met Pro Ser His Tyr Ser Pro Ser Val Tyr Val 85 90 95

Phe His Gly Gly Arg His Leu Ala Pro Ser Thr Gin Ala Pro Asn Leu

100 105 110

Thr Arg Leu Cys Glu Arg Ala Arg Arg His Phe Gly Phe Ser Asp Tyr 115 120 125 Ala Pro Arg Pro Cys Asp Leu Lys His Glu Thr Thr Gly Asp Ala Leu 130 135 140

Cys Glu Arg Leu Gly Leu Asp Pro Asp Arg Ala Leu Leu Tyr Leu Val 145 150 155 160

Ile Thr Glu Gly Phe Arg Glu Ala Val Cys Ile Ser Asn Thr Phe Leu 165 170 175

His Leu Gly Gly Met Asp Lys Val Thr Ile Gly Asp Ala Glu Val His

180 185 190

Arg Ile Pro Val Tyr Pro Leu Gin Met Phe Met Pro Asp Phe Ser Arg 195 200 205

Val Ile Ala Asp Pro Phe Asn Cys Asn His Arg Ser Ile Gly Glu Asn

210 215 220

Phe Asn Tyr Pro Leu Pro Phe Phe Asn Arg Pro Leu Ala Arg Leu Leu 225 230 235 240

Phe Glu Ala Val Val Gly Pro Ala Ala Val Arg Ala Arg Asn Val Asp

245 250 255

Ala Val Ala Arg Ala Ala Ala His Leu Ala Phe Asp Glu Asn His Glu 260 265 270 Gly Ala Ala Leu Pro Ala Asp Ile Thr Phe Thr Ala Phe Glu Ala Ser 275 280 285

Gin Gly Lys Pro Gin Arg Gly Ala Arg Asp Ala Gly Asn Lys Gly Pro

290 295 300

Ala Gly Gly Phe Glu Gin Arg Leu Ala Ser Val Met Ala Gly Asp Ala 305 310 315 320

Ala Leu Glu Ser Ile Val Ser Met Ala Val Phe Asp Glu Pro Pro Pro

325 330 335

Asp Ile Thr Thr Trp Pro Leu Leu Glu Gly Gin Glu Thr Pro Ala Ala 340 345 350 Arg Ala Gly Ala Val Gly Ala Tyr Leu Ala Arg Ala Ala Gly Leu Val 355 360 365

Gly Ala Met Val Phe Ser Thr Asn Ser Ala Leu His Leu Thr Glu Val

370 375 380

Asp Asp Ala Gly Pro Ala Asp Pro Lys Asp His Ser Lys Pro Ser Phe 385 390 395 400

Tyr Arg Phe Phe Leu Val Pro Gly Thr His Val Ala Ala Asn Pro Gin

405 410 415

Leu Asp Arg Glu Gly His Val Val Pro Gly Tyr Glu Gly Arg Pro Thr 420 425 430 Ala Pro Leu Val Gly Gly Thr Gin Glu Phe Ala Gly Glu His Leu Ala 435 440 445

Met Leu Cys Gly Phe Ser Pro Ala Leu Leu Ala Lys Met Leu Phe Tyr

450 455 460

Leu Glu Arg Cys Asp Gly Gly Val Ile Val Gly Arg Gin Glu Met Asp 465 470 475 480

Val Phe Arg Tyr Val Ala Asp Ser Gly Gin Thr Asp Val Pro Cys Asn

485 490 495

Leu Cys Thr Phe Glu Thr Arg His Ala Cys Ala His Thr Thr Leu Met 500 505 510 Arg Leu Arg Ala Arg His Pro Lys Phe Ala Ser Ala Arg Ala Ile Gly 515 520 525

Val Phe Gly Thr Met Asn Ser Ala Tyr Ser Asp Cys Asp Val Leu Gly 530 535 540 Asn Tyr Ala Ala Phe Ser Ala Leu Lys Arg Ala Asp Gly Ser Glu Asn

545 550 555 560

Thr Arg Thr Ile Met Gin Glu Tyr Ala Ala Thr Glu Arg Val Met Ala

565 ^" 570 575 Glu Leu Glu Ala Leu Gin Tyr Val Asp Gin Ala Val Pro Thr Ala Leu

580 585 590

Gly Arg Leu Glu Thr Ile Ile Gly Thr Arg Glu Ala Leu His Thr Val

595 600 605

Val Asn Asn Ile Lys Gin Leu Val 610 615

(2) INFORMATION FOR SEQ ID NO: 246:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1228 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:246:

Met Phe Cys Ala Ala Gly Gly Pro Thr Ser Pro Gly Gly Lys Ser Ala 1 5 10 15

Ala Arg Ala Ala Ser Gly Phe Phe Ala Pro His Asn Pro Arg Gly Ala

20 25 30

Thr Gin Thr Ala Pro Pro Pro Cys Arg Arg Gin Asn Phe Tyr Asn Pro 35 40 45 His Leu Ala Gin Thr Gly Thr Gin Pro Lys Ala Pro Gly Pro Ala Gin 50 55 60

Arg His Thr Tyr Tyr Ser Glu Cys Asp Glu Phe Arg Phe Ile Ala Pro 65 70 75 80

Arg Ser Leu Asp Glu Asp Ala Pro Ala Glu Gin Arg Thr Gly Val His 85 90 95

Asp Gly Arg Leu Arg Arg Ala Pro Lys Val Tyr Cys Gly Gly Asp Glu

100 105 110

Arg Asp Val Leu Arg Val Gly Pro Glu Gly Phe Trp Pro Arg Arg Leu 115 120 125 Arg Leu Trp Gly Gly Ala Asp His Ala Pro Glu Gly Phe Asp Pro Thr 130 135 140

Val Thr Val Phe His Val Tyr Asp Ile His Val Glu His Ala Tyr Ser 145 150 155 160 Met Arg Ala Ala Gin Leu His Glu Arg Phe Met Asp Ala Ile Thr Pro

165 170 175

Ala Gly Thr Val Ile Thr Leu Leu Gly Leu Thr Pro Glu Gly His Arg 180 185 190 Val Ala Val His Val Tyr Gly Thr Arg Gin Tyr Phe Tyr Met Asn Lys 195 200 205

Ala Glu Val Asp Arg His Leu Gin Cys Arg Ala Pro Arg Asp Leu Cys

210 215 220

Glu Arg Leu Ala Ala Ala Leu Arg Glu Ser Pro Gly Ala Ser Phe Arg 225 230 235 240

Gly Ile Ser Ala Asp His Phe Glu Ala Glu Val Val Glu Arg Ala Asp

245 250 255

Val Tyr Tyr Tyr Glu Trp Thr Leu Tyr Tyr Arg Val Phe Val Arg Ser 260 265 270 Gly Arg Ala Tyr Leu Cys Asp Asn Phe Cys Pro Ala Ile Arg Lys Tyr 275 280 285

Glu Gly Gly Val Asp Ala Thr Thr Arg Phe Ile Leu Asp Asn Pro Gly

290 295 300

Phe Val Thr Phe Gly Trp Tyr Arg Leu Lys Pro Gly Arg Gly Asn Ala 305 310 315 320

Pro Ala Gin Pro Arg Pro Pro Thr Ala Phe Gly Thr Ser Ser Asp Val

325 330 335

Glu Phe Asn Cys Thr Ala Asp Asn Leu Ala Val Glu Gly Ala Met Cys 340 345 350 Asp Leu Pro Ala Tyr Lys Leu Met Cys Phe Asp Ile Glu Cys Lys Ala 355 360 365

Gly Gly Glu Asp Glu Leu Ala Phe Pro Val Ala Glu Arg Pro Glu Asp

370 375 380

Leu Val Ile Gin Ile Ser Cys Leu Leu Tyr Asp Leu Ser Thr Thr Ala 385 390 395 400

Leu Glu His Ile Leu Leu Phe Ser Leu Gly Ser Cys Asp Leu Pro Glu

405 410 415

Ser His Leu Ser Asp Leu Ala Ser Arg Gly Leu Pro Ala Pro Val Val 420 425 430 Leu Glu Phe Asp Ser Glu Phe Glu Met Leu Leu Ala Phe Met Thr Phe 435 440 445

Val Lys Gin Tyr Gly Pro Glu Phe Val Thr Gly Tyr Asn Ile Ile Asn

450 455 460

Phe Asp Trp Pro Phe Val Leu Thr Lys Leu Thr Glu Ile Tyr Lys Val 465 470 475 480

Pro Leu Asp Gly Tyr Gly Arg Met Asn Gly Arg Gly Val Phe Arg Val

485 490 495

Trp Asp Ile Gly Gin Ser His Phe Gin Lys Arg Ser Lys Ile Lys Val 500 505 510

Asn Gly Met Val Asn Ile Asp Met Tyr Gly Ile Ile Thr Asp Lys Val

515 520 525

Lys Leu Ser Ser Tyr Lys Leu Asn Ala Val Ala Glu Ala Val Leu Lys 530 535 540

Asp Lys Lys Lys Asp Leu Ser Tyr Arg Asp Ile Pro Ala Tyr Tyr Ala

545 550 555 560

Ser Gly Pro Ala Gin Arg Gly Val Ile Gly Glu Tyr Cys Val Gin Asp

565 570 575 Ser Leu Leu Val Gly Gin Leu Phe Phe Lys Phe Leu Pro His Leu Glu

580 585 590

Leu Ser Ala Val Ala Arg Leu Ala Gly Ile Asn Ile Thr Arg Thr Ile

595 600 605

Tyr Asp Gly Gin Gin Ile Arg Val Phe Thr Cys Leu Leu Arg Leu Ala 610 615 620

Gly Gin Lys Gly Phe Ile Leu Pro Asp Thr Gin Gly Arg Phe Arg Gly

625 630 635 640

Leu Asp Lys Glu Ala Pro Lys Arg Pro Ala Val Pro Arg Gly Glu Gly

645 650 655 Glu Arg Pro Gly Asp Gly Asn Gly Asp Glu Asp Lys Asp Asp Asp Glu

660 665 670

Asp Gly Asp Glu Asp Gly Asp Glu Arg Glu Glu Val Ala Arg Glu Thr

675 680 685

Gly Gly Arg His Val Gly Tyr Gin Gly Ala Arg Val Leu Asp Pro Thr 690 695 700

Ser Gly Phe His Val Asp Pro Val Val Val Phe Asp Phe Ala Ser Leu

705 710 715 720

Tyr Pro Ser Ile Ile Gin Ala His Asn Leu Cys Phe Ser Thr Leu Ser

725 730 735 Leu Arg Pro Glu Ala Val Ala His Leu Glu Ala Asp Arg Asp Tyr Leu

740 745 750

Glu Ile Glu Val Gly Gly Arg Arg Leu Phe Phe Val Lys Ala His Val

755 760 765

Arg Glu Ser Leu Leu Ser Ile Leu Leu Arg Asp Trp Leu Ala Met Arg 770 775 780

Lys Gin Ile Arg Ser Arg Ile Pro Gin Ser Thr Pro Glu Glu Ala Val 785 790 795 800

Leu Leu Asp Lys Gin Gin Ala Ala Ile Lys Val Val Cys Asn Ser Val 805 810 815 Tyr Gly Phe Thr Gly Val Gin His Gly Leu Leu Pro Cys Leu His Val 820 825 830

Ala Ala Thr Val Thr Thr lie Gly Arg Glu Met Leu Leu Ala Thr Arg 835 840 845 Ala Tyr Val His Ala Arg Trp Ala Glu Phe Asp Gin Leu Leu Ala Asp

850 855 860

Phe Pro Glu Ala Ala Gly Met Arg Ala Pro Gly Pro Tyr Ser Met Arg 865 870 875 880 Ile Ile Tyr Gly Asp Thr Asp Ser Ile Phe Val Leu Cys Arg Gly Leu

885 890 895

Thr Ala Ala Gly Leu Val Ala Met Gly Asp Lys Met Ala Ser His Arg

900 905 910

Ala Leu Phe Leu Pro Pro Ile Lys Leu Glu Cys Glu Lys Thr Phe Thr 915 920 925

Lys Leu Leu Leu Ile Ala Lys Lys Lys Tyr Ile Gly Val Ile Cys Gly

930 935 940

Gly Lys Met Leu Ile Lys Gly Val Asp Leu Val Arg Lys Asn Asn Cys 945 950 955 960 Ala Phe Ile Asn Arg Thr Ser Arg Ala Leu Val Asp Leu Leu Phe Tyr

965 970 975

Asp Asp Thr Val Ser Gly Ala Ala Ala Ala Glu Arg Pro Ala Glu Glu

980 985 990

Trp Leu Ala Arg Pro Leu Pro Glu Gly Leu Gin Ala Phe Gly Ala Val 995 1000 1005

Leu Val Asp Ala His Arg Arg Ile Thr Asp Pro Glu Arg Asp Ile Gin

1010 1015 1020

Asp Phe Val Leu Thr Ala Glu Leu Ser Arg His Pro Arg Ala Tyr Thr 1025 1030 1035 104 Asn Lys Arg Leu Ala His Leu Thr Val Tyr Tyr Lys Leu Met Ala Arg

1045 1050 1055

Arg Ala Gin Val Pro Ser Ile Lys Asp Arg Ile Pro Tyr Val Ile Val

1060 1065 1070

Ala Gin Thr Arg Glu Val Glu Glu Thr Val Ala Arg Leu Ala Ala Leu 1075 1080 1085

Arg Glu Leu Asp Ala Ala Ala Pro Gly Asp Glu Pro Ala Pro Pro Ala

1090 1095 1100

Ala Leu Pro Ser Pro Ala Lys Arg Pro Arg Glu Thr Pro Ser His Ala 1105 1110 1115 112 Asp Pro Pro Gly Gly Ala Ser Lys Pro Arg Lys Leu Leu Val Ser Glu

1125 1130 1135

Leu Ala Glu Asp Pro Gly Tyr Ala Ile Arg Val Pro Leu Asn Thr Asp

1140 1145 1150

Tyr Tyr Phe Ser His Leu Leu Gly Ala Ala Cys Val Thr Phe Lys Ala 1155 1160 1165

Leu Phe Gly Asn Asn Ala Lys Ile Thr Glu Ser Leu Leu Lys Arg Phe

1170 1175 1180

Ile Pro Glu Thr Trp His Pro Pro Asp Asp Val Ala Ala Arg Leu Arg 1185 1190 1195 120

Ala Ala Gly Phe Gly Pro Ala Gly Ala Gly Ala Thr Ala Glu Glu Thr

1205 1210 1215

Arg Arg Met Leu His Arg Ala Phe Asp Thr Leu Ala 1220 1225

(2) INFORMATION FOR SEQ ID NO: 247:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 303 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:247:

Met Tyr Asp Ile Ala Pro Arg Arg Ser Gly Ser Arg Pro Gly Pro Gly 1 5 10 15

Arg Asp Lys Thr Arg Arg Arg Ser Arg Phe Ser Ala Ala Gly Asn Pro

20 25 30

Gly Val Glu Arg Arg Ala Ser Arg Lys Ser Leu Pro Ser His Ala Arg 35 40 45 Arg Leu Glu Leu Cys Leu His Glu Arg Arg Arg Tyr Arg Gly Phe Phe 50 55 60

Ala Ala Gin Thr Pro Ser Glu Glu Ile Ala Ile Val Arg Ser Leu Ser 65 70 75 80

Val Pro Leu Val Lys Thr Thr Pro Val Ser Leu Pro Phe Ser Leu Asp 85 90 95

Gin Thr Val Ala Asp Asn Cys Leu Thr Leu Ser Gly Met Gly Tyr Tyr

100 105 110

Leu Gly Ile Gly Gly Cys Cys Pro Ala Cys Ser Ala Gly Asp Gly Arg 115 120 125 Leu Ala Thr Val Ser Arg Glu Ala Leu Ile Leu Ala Phe Val Gin Gin 130 135 140

Ile Asn Thr Ile Phe Glu His Arg Thr Phe Leu Ala Ser Leu Val Val 145 150 155 160

Leu Ala Asp Arg His Ser Thr Pro Leu Gin Asp Leu Leu Ala Asp Thr 165 170 175

Leu Gly Gin Pro Glu Leu Phe Phe Val His Thr Ile Leu Arg Gly Gly

180 185 190

Gly Ala Cys Asp Pro Arg Phe Leu Phe Tyr Pro Asp Pro Thr Tyr Gly 195 200 205

Gly His Met Leu Tyr Val Ile Phe Pro Gly Thr Ser Ala His Leu His

210 215 220

Tyr Arg Leu Ile Asp Arg Met Leu Thr Ala Cys Pro Gly Tyr Arg Phe 225 230 235 240

Ala Ala His Val Trp Gin Ser Thr Phe Val Leu Val Val Arg Arg Asn

245 250 255

Ala Glu Lys Pro Ala Asp Ala Glu Ile Pro Thr Val Ser Ala Ala Asp 260 265 270 Ile Tyr Cys Lys Met Arg Asp Ile Ser Phe Asp Gly Gly Leu Met Leu 275 280 285

Glu Tyr Gin Arg Leu Tyr Ala Thr Phe Asp Glu Phe Pro Pro Pro 290 295 300

(2) INFORMATION FOR SEQ ID NO: 248:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 590 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 248:

Met Ala Thr Ser Ala Pro Gly Val Pro Ser Ser Ala Ala Val Arg Glu

1 5 10 15

Glu Ser Pro Gly Ser Ser Trp Lys Glu Gly Ala Phe Glu Arg Pro Tyr 20 25 30

Val Ala Phe Asp Pro Asp Leu Leu Ala Leu Asn Glu Ala Leu Cys Ala

35 40 45

Glu Leu Leu Ala Ala Cys His Val Val Gly Val Pro Pro Ala Ser Ala 50 55 60 Leu Asp Glu Asp Val Glu Ser Asp Val Ala Pro Ala Pro Pro Arg Pro 65 70 75 80

Arg Gly Ala Ala Arg Glu Ala Ser Gly Gly Arg Gly Pro Gly Ser Arg

85 90 95

Pro Pro Ala Asp Pro Thr Ala Glu Gly Leu Leu Asp Thr Gly Pro Phe 100 105 110

Ala Ala Ala Ser Val Asp Thr Phe Ala Leu Asp Arg Pro Cys Leu Val

115 120 125

Cys Arg Thr Ile Glu Leu Tyr Lys Gin Ala Tyr Arg Leu Ser Pro Gin 130 135 140

Trp Val Ala Asp Tyr Ala Phe Leu Cys Ala Lys Cys Leu Gly Ala Pro 145 150 155 160

His Cys Ala Ala Ser Ile Phe Val Ala Ala Phe Glu Phe Val Tyr Val 165 170 175

Met Asp His His Phe Leu Arg Thr Lys Lys Ala Thr Leu Val Gly Ser

180 185 190

Phe Ala Arg Phe Ala Leu Thr Ile Asn Asp Ile His Arg His Phe Phe 195 200 205 Leu His Cys Cys Phe Arg Thr Asp Gly Gly Val Pro Gly Arg His Ala 210 215 220

Gin Lys Gin Pro Arg Pro Thr Pro Ser Pro Gly Ala Ala Lys Val Gin 225 230 235 240

Tyr Ser Asn Tyr Ser Phe Leu Ala Gin Ser Ala Thr Arg Ala Leu Ile 245 250 255

Gly Thr Leu Ala Ser Gly Gly Asp Asp Gly Ala Gly Ala Gly Gly Gly

260 265 270

Ser Gly Thr Gin Pro Ser Leu Thr Thr Ala Leu Met Asn Trp Lys Asp 275 280 285 Cys Ala Arg Leu Leu Asp Cys Thr Glu Gly Lys Arg Gly Gly Gly Asp 290 295 300

Ser Cys Cys Thr Arg Ala Ala Ala Arg Asn Gly Glu Phe Glu Ala Ala 305 310 315 320

Ala Gly Ala Gin Gly Gly Glu Pro Glu Thr Trp Ala Tyr Ala Asp Leu 325 330 335 lie Leu Leu Leu Leu Ala Gly Thr Pro Ala Val Trp Glu Ser Gly Pro

340 345 350

Arg Leu Arg Ala Ala Ala Asp Ala Arg Arg Ala Ala Val Ser Glu Ser 355 360 365 Trp Glu Ala His Arg Gly Ala Arg Met Arg Asp Ala Ala Pro Arg Phe 370 375 380

Ala Gin Phe Ala Glu Pro Lys Ala Gin Pro Asp Leu Asp Leu Gly Pro 385 390 395 400

Leu Met Ala Thr Val Leu Lys His Gly Arg Gly Arg Gly Arg Thr Gly 405 410 415

Gly Glu Cys Leu Leu Cys Asn Leu Leu Leu Val Arg Ala Tyr Trp Leu

420 425 430

Ala Met Arg Arg Leu Arg Ala Ser Val Val Arg Tyr Ser Glu Asn Asn 435 440 445 Thr Ser Leu Phe Asp Cys Ile Val Pro Val Val Asp Gin Leu Glu Ala 450 455 460

Asp Pro Glu Ala Gin Pro Gly Asp Gly Gly Arg Phe Val Ser Leu Leu 465 470 475 480 Arg Ala Ala Gly Pro Glu Ala Ile Phe Lys His Met Phe Cys Asp Pro

485 490 495

Met Cys Ala Ile Thr Glu Met Glu Val Asp Pro Trp Val Leu Phe Gly

500 505 510

His Pro Arg Ala Asp His Arg Asp Glu Leu Gin Leu His Lys Ala Lys

515 520 525

Leu Ala Cys Gly Asn Glu Phe Glu Gly Arg Val Cys Ile Ala Leu Arg

530 535 540

Ala Leu Ile Tyr Thr Phe Lys Thr Tyr Gin Val Phe Val Pro Lys Pro 545 550 555 560

Thr Ala Thr Phe Val Arg Glu Ala Gly Ala Leu Leu Arg Arg His Ser

565 570 575

Ile Ser Leu Leu Ser Leu Glu His Thr Leu Cys Thr Tyr Val 580 585 590

(2) INFORMATION FOR SEQ ID NO: 249:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 128 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 249:

Met Ala Gly Arg Ala Gly Arg Trp Arg Thr Leu Arg Asp Ala Ile Pro 1 5 10 15 Asp Cys Ala Leu Arg Ser Gin Thr Leu Glu Ser Leu Asp Ala Arg Tyr 20 25 30

Val Ser Arg Asp Gly Ala Gly Asp Ala Ala Val Trp Phe Glu Asp Met

35 40 45

Thr Pro Ala Glu Leu Glu Val Ile Phe Pro Thr Thr Asp Ala Lys Leu 50 55 60

Asn Tyr Leu Ser Arg Thr Gin Arg Leu Ala Ser Leu Leu Thr Tyr Ala 65 70 75 80

Gly Pro Ile Lys Ala Pro Asp Gly Pro Ala Ala Pro His Thr Gin Asp 85 90 95 Thr Ala Cys Val His Gly Glu Leu Leu Ala Arg Lys Arg Glu Arg Phe 100 105 110

Ala Ala Val Ile Asn Arg Phe Leu Asp Leu His Gin Ile Leu Arg Gly 115 120 125 (2) INFORMATION FOR SEQ ID NO: 250:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 112 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:250:

Met Ala Ala Pro Gin Phe His Arg Pro Ser Thr Ile Thr Ala Asp Asn 1 5 10 15

Val Arg Ala Leu Gly Met Arg Gly Leu Val Leu Ala Thr Asn Asn Ala

20 25 30

Gin Phe Ile Met Asp Asn Ser Tyr Pro His Pro His Gly Thr Gin Gly 35 40 45 Ala Val Arg Glu Phe Leu Arg Gly Gin Ala Ala Ala Leu Thr Asp Leu 50 55 60

Gly Val Thr His Ala Asn Asn Thr Phe Ala Pro Gin Pro Met Phe Ala 65 70 75 80

Gly Asp Ala Ala Ala Glu Trp Leu Arg Pro Ser Phe Gly Leu Lys Arg 85 90 95

Thr Tyr Ser Pro Phe Val Val Arg Asp Pro Lys Thr Pro Ser Thr Pro 100 105 110

(2) INFORMATION FOR SEQ ID NO: 251:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 112 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 251:

Met Ala Ala Pro Gin Phe His Arg Pro Ser Thr Ile Thr Ala Asp Asn

1 5 10 15

Val Arg Ala Leu Gly Met Arg Gly Leu Val Leu Ala Thr Asn Asn Ala 20 25 30

Gin Phe Ile Met Asp Asn Ser Tyr Pro His Pro His Gly Thr Gin Gly

35 40 45

Ala Val Arg Glu Phe Leu Arg Gly Gin Ala Ala Ala Leu Thr Asp Leu 50 55 60

Gly Val Thr His Ala Asn Asn Thr Phe Ala Pro Gin Pro Met Phe Ala 65 70 75 80

Gly Asp Ala Ala Ala Glu Trp Leu Arg Pro Ser Phe Gly Leu Lys Arg 85 90 95 Thr Tyr Ser Pro Phe Val Val Arg Asp Pro Lys Thr Pro Ser Thr Pro 100 105 110

(2) INFORMATION FOR SEQ ID NO: 252:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3051 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:252:

Met Ile Pro Ala Ala Leu Pro His Pro Thr Met Lys Arg Gin Gly Asp 1 5 10 15

Arg Asp Ile Val Val Thr Gly Val Arg Asn Gin Phe Ala Thr Asp Leu

20 25 30

Glu Pro Gly Gly Ser Val Ser Cys Met Arg Ser Ser Leu Ser Phe Leu 35 40 45

Ser Leu Leu Phe Asp Val Gly Pro Arg Asp Val Leu Ser Ala Glu Ala

50 55 60

Ile Glu Gly Cys Leu Val Glu Gly Gly Glu Trp Thr Arg Ala Ala Ala 65 70 75 80 Gly Ser Gly Pro Pro Arg Met Cys Ser Ile Ile Glu Leu Pro Asn Phe

85 90 95

Leu Glu Tyr Pro Ala Arg Gly Leu Arg Cys Val Phe Ser Arg Val Tyr

100 105 110

Gly Glu Val Gly Phe Phe Gly Glu Pro Thr Ala Gly Leu Leu Glu Thr 115 120 125

Gin Cys Pro Ala His Thr Phe Phe Ala Gly Pro Trp Ala Met Arg Pro

130 135 140

Leu Ser Tyr Thr Leu Leu Thr Ile Gly Pro Leu Gly Met Gly Arg Asp 145 150 155 160

Gly Asp Thr Ala Tyr Leu Phe Asp Pro His Gly Leu Pro Ala Gly Thr 165 170 175

Pro Ala Phe Ile Ala Lys Val Arg Ala Gly Asp Val Tyr Pro Tyr Leu

180 185 190

Thr Tyr Tyr Ala His Asp Arg Pro Lys Val Arg Trp Ala Gly Ala Met 195 200 205

Val Phe Phe Val Pro Ser Gly Pro Gly Ala Val Ala Pro Ala Asp Leu

210 215 220

Thr Ala Ala Ala Leu His Leu Tyr Gly Ala Ser Glu Thr Tyr Leu Gin

225 230 235 240

Asp Glu Pro Phe Val Glu Arg Arg Val Ala Ile Thr His Pro Leu Arg 245 250 255

Gly Glu Ile Gly Gly Leu Gly Ala Leu Phe Val Gly Val Val Pro Arg

260 265 270

Gly Asp Gly Glu Gly Ser Gly Pro Val Val Pro Ala Leu Pro Ala Pro 275 280 285

Thr His Val Gin Thr Pro Arg Ala Asp Arg Pro Pro Glu Ala Pro Arg

290 295 300

Gly Ala Ser Gly Pro Pro Asn Thr Pro Gin Ala Gly His Pro Asn Arg

305 310 315 320

Pro Pro Asp Asp Val Trp Ala Ala Ala Leu Glu Gly Thr Pro Pro Ala 325 330 335

Lys Pro Ser Ala Pro Asp Ala Ala Ala Ser Gly Pro Pro His Ala Ala 340 345 350

Pro Pro Pro Gin Thr Pro Ala Gly Asp Ala Ala Glu Glu Ala Glu Asp 355 360 365

Leu Arg Val Leu Glu Val Gly Ala Val Pro Val Gly Arg His Arg Ala

370 375 380

Arg Tyr Ser Thr Gly Leu Pro Lys Arg Arg Arg Pro Thr Trp Thr Pro

385 390 395 400

Pro Ser Ser Val Glu Asp Leu Thr Ser Gly Glu Arg Pro Ala Pro Lys 405 410 415

Ala Pro Pro Ala Lys Ala Lys Lys Lys Ser Ala Pro Lys Lys Lys Ala 420 425 430

Pro Val Ala Ala Glu Val Pro Ala Ser Ser Pro Thr Pro Ile Ala Ala 435 440 445

Thr Val Pro Pro Ala Pro Asp Thr Pro Pro Gin Ser Gly Gin Gly Gly

450 455 460

Gly Asp Asp Gly Pro Asp Ser Ser Pro Ser Val Leu Glu Thr Leu Gly

465 470 475 480

Ala Arg Arg Pro Pro Glu Pro Pro Gly Ala Asp Leu Ala Gin Leu Phe 485 490 495 Glu Val His Pro Asn Val Ala Ala Thr Ala Val Arg Leu Ala Ala Arg

500 505 510

Asp Ala Ala Arg Glu Val Ala Ala Cys Ser Gin Leu Thr Ile Asn Ala 515 520 525 Leu Arg Ser Pro Tyr Pro Ala His Pro Gly Leu Leu Glu Leu Cys Val 530 535 540

Ile Phe Phe Phe Glu Arg Val Leu Ala Phe Leu Ile Glu Asn Gly Ala 545 550 555 560

Arg Thr His Thr Gin Ala Gly Val Ala Gly Pro Ala Ala Ala Leu Leu 565 570 575

Asp Phe Thr Leu Arg Met Leu Pro Arg Lys Thr Ala Val Gly Asp Phe

580 585 590

Leu Ala Ser Thr Arg Met Ser Leu Ala Asp Val Ala Ala His Arg Pro 595 600 605 Leu Ile Gin His Val Leu Asp Glu Asn Ser Gin Ile Gly Arg Leu Ala 610 615 620

Lys Leu Val Leu Val Ala Arg Asp Val Ile Arg Glu Thr Asp Ala Phe 625 630 635 640

Tyr Gly Asp Leu Ala Asp Leu Asp Leu Gin Leu Arg Ala Ala Pro Pro 645 650 655

Ala Asn Leu Tyr Ala Arg Leu Gly Glu Trp Leu Leu Glu Arg Ser Arg

660 665 670

Ala His Pro Asn Thr Leu Phe Ala Pro Ala Thr Pro Thr His Pro Glu 675 680 685 Pro Leu Leu His Arg Ile Gin Ala Gin Phe Arg Glu Glu Met Arg Val 690 695 700

Glu Ala Glu Ala Arg Glu Met Arg Glu Ala Leu Asp Arg Val Asp Ser 705 710 715 720

Val Ser Gin Arg Ala Gly Pro Leu Thr Val Met Pro Val Pro Ala Ala 725 730 735

Pro Gly Ala Gly Gly Arg Ala Pro Cys Pro Pro Ala Leu Gly Pro Glu

740 745 750

Ala Ile Gin Ala Arg Leu Glu Asp Val Arg Ile Gin Ala Arg Arg Ala 755 760 765 Ile Glu Ser Ala Ile Lys Glu Tyr Phe His Arg Gly Ala Val Tyr Ser 770 775 780

Ala Lys Ala Leu Gin Ala Ser Asp Ser His Asp Cys Arg Phe His Val 785 790 795 800

Ala Ser Ala Ala Val Val Pro Met Val Gin Leu Leu Glu Ser Leu Pro 805 810 815

Ala Phe Asp Gin His Thr Arg Asp Val Ala Gin Arg Ala Ala Leu Pro

820 825 830

Pro Pro Pro Pro Leu Ala Thr Ser Pro Gin Ala Ile Leu Leu Arg Asp 835 840 845

Leu Leu Gin Arg Gly Gin Thr Leu Asp Ala Pro Glu Asp Leu Ala Ala

850 855 860

Trp Leu Ser Val Leu Thr Asp Ala Ala Thr Gin Gly Leu Ile Glu Arg 865 870 875 880

Lys Pro Leu Glu Glu Leu Ala Arg Ser Ile His Gly Ile Asn Asp Gin

885 890 895

Gin Ala Arg Arg Ser Ser Gly Leu Ala Glu Leu Gin Arg Phe Asp Ala 900 905 910 Leu Asp Ala Ala Gin Gin Leu Asp Ser Asp Ala Ala Phe Val Pro Ala 915 920 925

Thr Gly Pro Ala Pro Tyr Val Asp Gly Gly Gly Leu Ser Pro Glu Ala

930 935 940

Thr Arg Met Ala Glu Asp Ala Leu Arg Gin Ala Arg Ala Met Glu Ala 945 950 955 960

Ala Lys Met Thr Ala Glu Leu Ala Pro Glu Ala Arg Ser Arg Leu Arg

965 970 975

Glu Arg Ala His Ala Leu Glu Ala Met Leu Asn Asp Ala Arg Glu Arg 980 985 990 Ala Lys Val Ala His Asp Ala Arg Glu Lys Phe Leu His Lys Leu Gin 995 1000 1005

Gly Val Leu Arg Pro Leu Pro Asp Phe Val Gly Leu Lys Ala Cys Pro

1010 1015 1020

Ala Val Leu Ala Thr Leu Arg Ala Ser Leu Pro Ala Gly Trp Thr Asp 1025 1030 1035 104

Leu Ala Asp Ala Val Arg Gly Pro Pro Pro Glu Val Thr Ala Ala Leu

1045 1050 1055

Arg Ala Asp Leu Trp Gly Leu Leu Gly Gin Tyr Arg Glu Ala Leu Glu 1060 1065 1070 His Pro Thr Pro Asp Thr Ala Thr Ala Gly Leu His Pro Ala Phe Val 1075 1080 1085

Val Val Leu Lys Thr Leu Phe Ala Asp Ala Pro Glu Thr Pro Val Leu

1090 1095 1100

Val Gin Phe Phe Ser Asp His Ala Pro Thr Ile Ala Lys Ala Val Ser 1105 1110 1115 112

Asn Ala Ile Asn Ala Gly Ser Ala Ala Val Ala Thr Asp Ala Ala Thr

1125 1130 1135

Val Asp Ala Ala Val Arg Ala His Gly Ala Asp Ala Val Ser Ala Leu 1140 1145 1150 Gly Ala Ala Ala Arg Asp Pro Asp Leu Ser Phe Leu Ala Ala Asp Ser 1155 1160 1165

Ala Ala Gly Tyr Val Lys Ala Thr Arg Leu Ala Leu Glu Arg Ala Ile 1170 1175 1180 Asp Glu Leu Thr Thr Leu Gly Ser Ala Ala Ala Asp Leu Val Val Gin

1185 1190 1195 120

Ala Arg Arg Ala Cys Ala Gin Pro Glu Gly Asp His Ala Ala Leu Ile

1205 1210 1215 Asp Ala Ala Ala Arg Ala Thr Thr Ala Ala Arg Glu Ser Leu Ala Gly

1220 1225 1230

His Glu Ala Gly Phe Gly Gly Leu Leu His Ala Glu Gly Thr Ala Gly

1235 1240 1245

Asp His Ser Pro Ser Gly Arg Ala Leu Gin Glu Leu Gly Lys Val Ile 1250 1255 1260

Gly Ala Thr Arg Arg Arg Ala Asp Glu Leu Glu Ala Ala Val Ala Asp

1265 1270 1275 128

Leu Thr Ala Lys Met Ala Ala Gin Arg Arg Ser Ser Trp Ala Ala Gly

1285 1290 1295 Val Glu Ala Ala Leu Asp Arg Val Glu Asn Arg Ala Glu Phe Asp Val

1300 1305 1310

Val Glu Leu Arg Arg Leu Gin Ala Gly Thr His Gly Tyr Asn Pro Arg

1315 1320 1325

Asp Phe Arg Lys Arg Ala Glu Gin Ala Ala Asn Ala Glu Ala Val Thr 1330 1335 1340

Leu Ala Leu Asp Thr Ala Phe Ala Phe Asn Pro Tyr Thr Pro Glu Asn

1345 1350 1355 136

Gin Arg His Pro Met Leu Pro Pro Leu Ala Ala Ile His Arg Leu Gly

1365 1370 1375 Trp Ser Ala Ala Phe His Ala Ala Ala Glu Thr Tyr Ala Asp Met Phe

1380 1385 1390

Arg Val Asp Ala Glu Pro Leu Ala Arg Leu Leu Arg Ile Ala Glu Gly

1395 1400 1405

Leu Leu Glu Met Ala Gin Ala Gly Asp Gly Phe Ile Asp Tyr His Glu 1410 1415 1420

Ala Val Gly Arg Leu Ala Asp Asp Met Thr Ser Val Pro Gly Leu Arg

1425 1430 1435 144

Arg Tyr Val Pro Phe Phe Gin His Gly Tyr Ala Asp Tyr Val Glu Leu

1445 1450 1455 Arg Asp Arg Leu Asp Ala Ile Arg Ala Asp Val His Arg Ala Leu Gly

1460 1465 1470

Gly Val Pro Leu Asp Leu Ala Ala Ala Ala Glu Gin Ile Ser Ala Ala

1475 1480 1485

Arg Asn Asp Pro Glu Ala Thr Ala Glu Leu Val Arg Thr Gly Val Thr 1490 1495 1500

Leu Pro Cys Pro Ser Glu Asp Ala Leu Val Ala Cys Ala Ala Ala Leu 1505 1510 1515 152

Glu Arg Val Asp Gin Ser Pro Val Lys Asn Thr Ala Tyr Ala Glu Tyr 1525 1530 1535

Val Ala Phe Val Thr Arg Gin Asp Thr Ala Glu Thr Lys Asp Ala Val

1540 1545 1550

Val Arg Ala Lys Gin Gin Arg Ala Glu Ala Thr Glu Arg Val Met Ala 1555 1560 1565

Gly Leu Arg Glu Ala Ala Arg Glu Arg Arg Ala Gin Ile Glu Ala Glu

1570 1575 1580

Gly Leu Ala Asn Leu Lys Thr Met Leu Lys Val Val Ala Val Pro Ala 1585 1590 1595 160 Thr Val Ala Lys Thr Leu Asp Gin Ala Arg Ser Val Ala Glu Ile Ala

1605 1610 1615

Asp Gin Val Glu Val Leu Leu Asp Gin Thr Glu Lys Thr Arg Glu Leu

1620 1625 1630

Asp Val Pro Ala Val Ile Trp Leu Glu His Ala Gin Arg Thr Phe Glu 1635 1640 1645

Thr His Pro Leu Ser Ala Arg Asp Gly Pro Gly Pro Leu Ala Arg His

1650 1655 1660

Ala Gly Arg Leu Gly Ala Leu Phe Asp Thr Arg Arg Arg Val Asp Ala 1665 1670 1675 168 Leu Arg Arg Ser Leu Glu Glu Ala Glu Ala Glu Trp Asp Glu Val Trp

1685 1690 1695

Gly Arg Phe Gly Arg Val Arg Gly Gly Ala Trp Lys Ser Pro Glu Gly

1700 1705 1710

Phe Arg Ala Met His Glu Gin Leu Arg Ala Leu Gin Asp Thr Thr Asn 1715 1720 1725

Thr Val Ser Gly Leu Arg Ala Gin Pro Ala Tyr Glu Arg Leu Ser Ala

1730 1735 1740

Arg Tyr Gin Gly Val Leu Gly Ala Lys Gly Ala Glu Arg Ala Glu Ala 1745 1750 1755 176 Val Glu Glu Leu Gly Ala Arg Val Thr Lys His Thr Ala Leu Cys Ala

1765 1770 1775

Arg Leu Arg Asp Glu Val Val Arg Arg Val Pro Trp Glu Met Asn Phe

1780 1785 1790

Asp Ala Leu Gly Arg Leu Leu Ala Glu Phe Asp Ala Ala Ala Ala Asp 1795 1800 1805

Leu Ala Pro Trp Ala Val Glu Glu Phe Arg Gly Ala Arg Glu Leu Ile

1810 1815 1820

Gin Arg Arg Met Gly Ser Ala Tyr Ala Arg Ala Gly Gly Gin Thr Gly 1825 1830 1835 184 Ala Gly Ala Ala Ala Ala Pro Ala Pro Leu Leu Val Asp Leu Arg Ala

1845 1850 1855

Leu Asp Ala Arg Ala Arg Ala Ser Ser Ser Pro Glu Gly His Glu Val 1860 1865 1870 Asp Pro Gin Leu Leu Arg Arg Arg Gly Glu Ala Tyr Leu Arg Ala Gly

1875 1880 1885

Gly Asp Pro Gly Pro Leu Val Leu Arg Glu Ala Val Ser Ala Leu Asp

1890 1895 1900 Leu Pro Phe Ala Thr Ser Phe Leu Ala Pro Asp Gly Thr Pro Leu Gin

1905 1910 1915 192

Tyr Ala Leu Cys Phe Pro Ala Val Thr Asp Lys Leu Gly Ala Leu Leu

1925 1930 1935

Met Arg Pro Glu Ala Ala Cys Val Arg Pro Pro Leu Pro Thr Asp Val 1940 1945 1950

Leu Glu Ser Ala Pro Thr Val Thr Ala Met Tyr Val Leu Thr Val Val

1955 1960 1965

Asn Arg Leu Gin Leu Ala Leu Ser Asp Ala Gin Ala Ala Asn Phe Gin

1970 1975 1980 Leu Phe Gly Arg Phe Val Arg His Arg Gin Ala Thr Trp Gly Ala Ser

1985 1990 1995 200

Met Asp Ala Ala Ala Glu Leu Tyr Val Val Ala Thr Thr Leu Thr Arg

2005 2010 2015

Glu Phe Gly Cys Arg Trp Ala Gin Leu Gly Trp Ala Ser Gly Ala Ala 2020 2025 2030

Ala Pro Arg Pro Pro Pro Gly Pro Arg Gly Ser Gin Arg His Cys Val

2035 2040 2045

Ala Phe Asn Glu Asn Asp Val Leu Val Val Ala Gly Val Pro Glu His

2050 2055 2060 Ile Tyr Asn Phe Trp Arg Leu Asp Leu Val Arg Gin His Glu Tyr Met

2065 2070 2075 208

His Leu Thr Leu Glu Arg Ala Phe Glu Asp Ala Ala Glu Ser Met Leu

2085 2090 2095

Phe Val Gin Arg Leu Thr Pro His Pro Asp Ala Arg Ile Arg Val Leu 2100 2105 2110

Pro Thr Phe Leu Asp Gly Gly Pro Pro Thr Arg Gly Leu Leu Phe Gly

2115 2120 2125

Thr Arg Leu Ala Asp Trp Arg Arg Gly Lys Leu Ser Glu Thr Asp Pro

2130 2135 2140 Leu Ala Pro Trp Arg Ser Ala Leu Glu Leu Gly Thr Gin Arg Arg Asp

2145 2150 2155 216

Ala Pro Ala Leu Gly Lys Leu Ser Pro Ala Gin Ala Ala Val Ser Val

2165 2170 2175

Leu Gly Arg Met Cys Leu Pro Ser Ala Ala Ala Leu Trp Thr Cys Met 2180 2185 2190

Phe Pro Asp Asp Tyr Thr Glu Tyr Asp Ser Phe Asp Ala Leu Leu Ala

2195 2200 2205

Ala Arg Leu Glu Ser Gly Gin Thr Leu Gly Pro Ala Gly Gly Arg Glu 2210 2215 2220

Ala Ser Leu Pro Glu Ala Pro His Ala Leu Tyr Arg Pro Thr Gly Gin 2225 2230 _ 2235 224

His Val Ala Val Leu Ala Ala Ala Thr Thr Pro Ala Ala Arg Val Thr 2245 2250 2255

Ala Met Asp Leu Val Leu Ala Ala Val Leu Leu Gly Ala Pro Val Val

2260 2265 2270

Val Arg Asn Thr Thr Ala Phe Ser Arg Glu Ser Glu Leu Glu Leu Cys 2275 2280 2285 Leu Thr Leu Phe Asp Ser Arg Pro Gly Gly Pro Asp Ala Ala Leu Arg 2290 2295 2300

Asp Val Val Ser Ser Asp Ile Glu Thr Trp Ala Val Gly Leu Leu His 2305 2310 2315 232

Thr Asp Leu Asn Pro Ile Glu Asn Ala Cys Leu Ala Ala Gin Leu Pro 2325 2330 2335

Arg Leu Ser Ala Leu Ile Ala Glu Arg Pro Leu Ala Asp Gly Pro Pro

2340 2345 2350

Cys Leu Val Leu Val Asp Ile Ser Met Thr Pro Val Ala Val Leu Trp 2355 2360 2365 Glu Ala Pro Glu Pro Pro Gly Pro Pro Asp Val Arg Phe Val Gly Ser 2370 2375 2380

Glu Ala Thr Glu Glu Leu Pro Phe Val Ala Thr Ala Gly Asp Val Leu 2385 2390 2395 240

Ala Ala Ser Ala Ala Asp Ala Asp Pro Phe Phe Ala Arg Ala Ile Leu 2405 2410 2415

Gly Arg Pro Phe Asp Ala Ser Leu Leu Thr Gly Glu Leu Phe Pro Gly

2420 2425 2430

His Pro Val Tyr Gin Arg Pro Leu Ala Asp Glu Ala Gly Pro Ser Ala 2435 2440 2445 Pro Thr Ala Ala Arg Asp Pro Arg Asp Leu Ala Gly Gly Asp Gly Gly 2450 2455 2460

Ser Gly Pro Glu Asp Pro Ala Ala Pro Pro Ala Arg Gin Ala Asp Pro 2465 2470 2475 248

Gly Val Leu Ala Pro Thr Leu Leu Thr Asp Ala Thr Thr Gly Glu Pro 2485 2490 2495

Val Pro Pro Arg Met Trp Ala Trp Ile His Gly Leu Glu Glu Leu Ala

2500 2505 2510

Ser Asp Asp Ala Gly Gly Pro Thr Pro Asn Pro Ala Pro Ala Leu Leu 2515 2520 2525 Pro Pro Pro Ala Thr Asp Gin Ser Val Pro Thr Ser Gin Tyr Ala Pro 2530 2535 2540

Arg Pro Ile Gly Pro Ala Ala Thr Ala Arg Glu Trp Ser Val Pro Pro 2545 2550 2555 256 Gin Gin Asn Thr Gly Arg Val Pro Val Ala Pro Arg Asp Asp Pro Arg

2565 2570 2575

Pro Ser Pro Pro Thr Pro Ser. Pro Pro Ala Asp Ala Ala Leu Pro Pro 2580 2585 2590 Pro Ala Phe Ser Gly Ser Ala Ala Ala Phe Ser Ala Ala Val Pro Arg 2595 2600 2605

Val Arg Arg Ser Arg Arg Thr Arg Ala Lys Ser Arg Ala Pro Arg Ala

2610 2615 2620

Ser Ala Pro Pro Glu Gly Trp Arg Pro Pro Ala Leu Pro Ala Pro Val 2625 2630 2635 264

Ala Pro Val Ala Ala Ser Ala Arg Pro Pro Asp Gin Pro Pro Thr Pro

2645 2650 2655

Glu Ser Ala Pro Pro Ala Trp Val Ser Ala Leu Pro Leu Pro Pro Gly 2660 2665 2670 Pro Ala Ser Arg Ala Phe Pro Ala Pro Thr Leu Ala Pro Ile Pro Pro 2675 2680 2685

Pro Pro Ala Glu Gly Ala Val Ala Pro Gly Asp Asp Arg Arg Arg Gly

2690 2695 2700

Arg Arg Gin Thr Thr Ala Gly Pro Ser Pro Thr Pro Pro Arg Gly Pro 2705 2710 2715 272

Ala Ala Gly Pro Pro Arg Arg Leu Trp Ala Val Ala Ser Leu Ser Ala

2725 2730 2735

Ser Leu Asn Ser Leu Pro Ser Pro Arg Asp Pro Ala Asp His Ala Ala 2740 2745 2750 Ala Val Ser Ala Ala Ala Ala Ala Val Pro Pro Ser Pro Gly Leu Ala 2755 2760 2765

Pro Pro Thr Ser Ala Val Gin Thr Ser Pro Pro Pro Leu Ala Pro Gly

2770 2775 2780

Pro Val Ala Pro Ser Glu Pro Leu Cys Gly Trp Val Val Pro Gly Gly 2785 2790 2795 280

Pro Val Ala Arg Arg Pro Pro Pro Gin Ser Pro Ala Thr Lys Pro Ala

2805 2810 2815

Ala Arg Thr Arg Ile Arg Ala Arg Ser Val Pro Gin Pro Pro Leu Pro 2820 2825 2830 Gin Pro Pro Leu Pro Gin Pro Pro Leu Pro Gin Pro Pro Leu Pro Gin 2835 2840 2845

Pro Pro Leu Pro Gin Pro Pro Leu Pro Gin Pro Pro Leu Pro Gin Pro

2850 2855 2860

Pro Leu Pro Gin Pro Pro Leu Pro Gin Pro Pro Leu Pro Gin Pro Pro 2865 2870 2875 288

Leu Pro Gin Pro Pro Leu Pro Gin Ser Arg Asp Ser Val Pro Thr Pro

2885 2890 2895

Glu Ser Pro Thr His Thr Asn Thr His Leu Pro Val Ser Ala Val Thr 2900 2905 2910

Ser Trp Ala Ser Ser Leu Ala Leu His Val Asp Ser Ala Pro Pro Pro

2915 . 2920 2925

Ala Ser Leu Leu Gin Thr Leu His Ser Asp Asp Glu His Ser Asp Ala 2930 2935 2940

Asp Ser Leu Arg Phe Ser Asp Ser Asp Asp Thr Glu Ala Leu Asp Pro

2945 2950 2955 296

Leu Pro Pro Glu Pro His Leu Pro Pro Ala Asp Glu Pro Pro Gly Pro

2965 2970 2975 Leu Ala Ala Asp His Leu Gin Ser Pro His Ser Gin Phe Gly Pro Leu

2980 2985 2990

Pro Val Gin Ala Asn Ala Val Leu Ser Arg Arg Tyr Val Arg Ser Thr

2995 3000 3005

Gly Arg Ser Ala Val Leu Ile Arg Ala Cys Arg Arg Ile Gin Gin Gin 3010 3015 3020

Leu Gin Arg Thr Arg Arg Ala Leu Phe Gin Arg Ser Asn Ala Val Leu 3025 3030 3035 304

Thr Ser Leu His His Val Arg Met Leu Leu Gly 3045 3050

(2) INFORMATION FOR SEQ ID NO: 253:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1124 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:253

Met Ala Asn Arg Pro Ala Ala Ser Ala Gly Ala Arg Ser Pro Ser Gin 1 5 10 15 Glu Pro Arg Glu Pro Glu Val Ala Pro Pro Gly Gly Asp His Val Phe 20 25 30

Cys Arg Lys Val Ser Gly Val Met Val Leu Ser Ser Asp Pro Pro Gly

35 40 45

Pro Ala Ala Tyr Arg Ile Ser Asp Ser Ser Phe Val Gin Cys Gly Ser 50 55 60

Asn Cys Ser Met Ile Ile Asp Gly Asp Val Arg His Leu Arg Asp Leu 65 70 75 80

Glu Gly Ala Thr Ser Thr Gly Ala Phe Val Ala Ile Ser Asn Val Ala 85 90 95

Ala Gly Gly Asp Gly Arg Thr Ala Val Val Gly Gly Thr Ser Gly Pro

100 _. 105 110

Ser Ala Thr Thr Ser Val Gly Thr Gin Thr Ser Gly Glu Phe Leu His 115 120 125

Gly Asn Pro Arg Thr Pro Glu Pro Gin Gly Pro Gin Ala Val Pro Pro

130 135 140

Pro Pro Pro Pro Pro Phe Pro Trp Gly His Glu Cys Cys Ala Arg Arg 145 150 155 160 Asp Arg Gly Ala Glu Lys Asp Val Gly Ala Ala Glu Ser Trp Ser Asp

165 170 175

Gly Pro Ser Ser Asp Ser Glu Thr Glu Asp Ser Asp Ser Ser Asp Glu

180 185 190

Asp Thr Gly Ser Gly Ser Glu Thr Leu Ser Arg Ser Ser Ser Ile Trp 195 200 205

Ala Ala Gly Ala Thr Asp Asp Asp Asp Ser Asp Ser Asp Ser Arg Ser

210 215 220

Asp Asp Ser Val Gin Pro Asp Val Val Val Arg Arg Arg Trp Ser Asp 225 230 235 240 Gly Pro Ala Pro Val Ala Phe Pro Lys Pro Arg Arg Pro Gly Asp Ser

245 250 255

Pro Gly Asn Pro Gly Leu Gly Ala Gly Thr Gly Pro Gly Ser Ala Thr

260 265 270

Asp Pro Arg Ala Ser Ala Asp Ser Asp Ser Ala Ala His Ala Ala Ala 275 280 285

Pro Gin Ala Asp Val Ala Pro Val Leu Asp Ser Gin Pro Thr Val Gly

290 295 300

Thr Asp Pro Gly Tyr Pro Val Pro Leu Glu Leu Thr Pro Glu Asn Ala 305 310 315 320 Glu Ala Val Ala Arg Phe Leu Gly Asp Ala Val Asp Arg Glu Pro Ala

325 330 335

Leu Met Leu Glu Tyr Phe Cys Arg Cys Ala Arg Glu Glu Ser Lys Arg

340 345 350

Val Pro Pro Arg Thr Phe Gly Ser Ala Pro Arg Leu Thr Glu Asp Asp 355 360 365

Phe Gly Leu Leu Asn Tyr Ala Glu Met Arg Arg Leu Cys Leu Asp Leu

370 375 380

Pro Pro Val Pro Pro Asn Ala Tyr Thr Pro Tyr His Leu Arg Glu Tyr 385 390 395 400 Ala Thr Arg Leu Val Asn Gly Phe Lys Pro Leu Val Arg Arg Ser Ala

405 410 415

Arg Leu Tyr Arg Ile Leu Gly Ile Leu Val His Leu Arg Ile Arg Thr 420 425 430 Arg Glu Ala Ser Phe Glu Glu Trp Met Arg Ser Lys Glu Val Asp Leu

435 440 445

Asp Phe Gly Leu Thr Glu Arg_. Leu Arg Glu His Glu Ala Gin Leu Met

450 455 460 Ile Leu Ala Gin Ala Leu Asn Pro Tyr Asp Cys Leu Ile His Ser Thr

465 470 475 480

Pro Asn Thr Leu Val Glu Arg Gly Leu Gin Ser Ala Leu Lys Tyr Glu

485 490 495

Glu Phe Tyr Leu Lys Arg Phe Gly Gly His Tyr Met Glu Ser Val Phe 500 505 510

Gin Met Tyr Thr Arg Ile Ala Gly Phe Leu Ala Cys Arg Ala Thr Arg

515 520 525

Gly Met Arg His Ile Ala Leu Gly Arg Gin Gly Ser Trp Trp Glu Met

530 535 540 Phe Lys Phe Phe Phe His Arg Leu Tyr Asp His Gin Ile Val Pro Ser

545 550 555 560

Thr Pro Ala Met Leu Asn Leu Gly Thr Arg Asn Tyr Tyr Thr Ser Ser

565 570 575

Cys Tyr Leu Val Asn Pro Gin Ala Thr Thr Asn Gin Ala Thr Leu Arg 580 585 590

Ala Ile Thr Gly Asn Val Ser Ala Ile Leu Ala Arg Asn Gly Gly Ile

595 600 605

Gly Leu Cys Met Gin Ala Phe Asn Asp Asp Gly Thr Ala Ser Ile Met

610 615 620 Pro Ala Leu Lys Val Leu Asp Ser Leu Val Ala Ala His Asn Lys Gin

625 630 635 640

Ser Trp Thr Gly Ala Cys Val Tyr Leu Glu Pro Trp His Ser Asp Val

645 650 655

Arg Ala Val Leu Arg Met Lys Gly Val Leu Ala Gly Glu Glu Ala Gin 660 665 670

Arg Cys Asp Asn Ile Phe Ser Ala Leu Trp Met Pro Asp Leu Phe Phe

675 680 685

Lys Arg Leu Ile Arg His Leu Asp Gly Glu Lys Asn Val Thr Trp Ser

690 695 700 Leu Phe Asp Arg Asp Thr Ser Met Ser Leu Ala Asp Phe His Gly Glu

705 710 715 720

Glu Phe Glu Lys Leu Tyr Glu His Leu Glu Ala Met Gly Phe Gly Glu

725 730 735

Thr Ile Pro Ile Gin Asp Leu Ala Tyr Ala Ile Val Arg Ser Ala Ala 740 745 750

Thr Thr Gly Ser Pro Phe Ile Met Phe Lys Asp Ala Val Asn Arg His

755 760 765

Tyr Ile Tyr Asp Thr Gin Gly Ala Ala Ile Ala Gly Ser Asn Leu Cys 770 775 780

Thr Glu Ile Val His Pro Ser Ser Lys Arg Ser Ser Gly Val Cys Asn 785 790 . 795 800

Leu Gly Ser Val Asn Leu Ala Arg Cys Val Ser Arg Arg Thr Phe Asp 805 810 815

Phe Gly Met Leu Arg Asp Ala Val Gin Ala Cys Val Leu Met Val Asn

820 825 830

Ile Met Ile Asp Ser Thr Leu Gin Pro Thr Pro Gin Cys Arg His Asp 835 840 845 Asn Leu Arg Ser Met Gly Ile Gly Met Gin Gly Leu His Thr Ala Cys 850 855 860

Leu Lys Met Gly Leu Asp Leu Glu Ser Ala Glu Phe Arg Asp Leu Asn 865 870 875 880

Thr His Ile Ala Glu Val Met Leu Leu Ala Ala Met Lys Thr Ser Asn 885 890 895

Ala Leu Cys Val Arg Gly Ala Arg Pro Phe Ser His Phe Lys Arg Ser

900 905 910

Met Tyr Arg Ala Gly Arg Phe His Trp Glu Arg Phe Ser Asn Asp Arg 915 920 925 Tyr Glu Gly Glu Trp Glu Met Leu Arg Gin Ser Met Met Lys His Gly 930 935 940

Leu Arg Asn Ser Gin Phe Ile Ala Leu Met Pro Thr Ala Ala Ser Ala 945 950 955 960

Gin Ile Ser Asp Val Ser Glu Gly Phe Ala Pro Leu Phe Thr Asn Leu 965 970 975

Phe Ser Lys Val Thr Arg Asp Gly Glu Thr Leu Arg Pro Asn Thr Leu

980 985 990

Leu Leu Lys Glu Leu Glu Arg Thr Phe Gly Gly Lys Arg Leu Leu Asp 995 1000 1005 Ala Met Asp Gly Leu Glu Ala Lys Gin Trp Ser Val Ala Gin Ala Leu 1010 1015 1020

Pro Cys Leu Asp Pro Ala His Pro Leu Arg Arg Phe Lys Thr Ala Phe 1025 1030 1035 104

Asp Tyr Asp Gin Glu Leu Leu Ile Asp Leu Cys Ala Asp Arg Ala Pro 1045 1050 1055

Tyr Val Asp His Ser Gin Ser Met Thr Leu Tyr Val Thr Glu Lys Ala

1060 1065 1070

Asp Gly Thr Leu Pro Ala Ser Thr Leu Val Arg Leu Leu Val His Ala 1075 1080 1085 Tyr Lys Arg Gly Leu Lys Thr Gly Met Tyr Tyr Cys Lys Val Arg Lys 1090 1095 1100

Ala Thr Asn Ser Gly Val Phe Ala Gly Asp Asp Asn Ile Val Cys Thr 1105 1110 1115 112 Ser Cys Ala Leu

(2) INFORMATION FOR SEQ ID NO: 254:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1124 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 254:

Met Ala Asn Arg Pro Ala Ala Ser Ala Gly Ala Arg Ser Pro Ser Gin

1 5 10 15

Glu Pro Arg Glu Pro Glu Val Ala Pro Pro Gly Gly Asp His Val Phe 20 25 30 Cys Arg Lys Val Ser Gly Val Met Val Leu Ser Ser Asp Pro Pro Gly 35 40 45

Pro Ala Ala Tyr Arg Ile Ser Asp Ser Ser Phe Val Gin Cys Gly Ser

50 55 60

Asn Cys Ser Met Ile Ile Asp Gly Asp Val Arg His Leu Arg Asp Leu 65 70 75 80

Glu Gly Ala Thr Ser Thr Gly Ala Phe Val Ala Ile Ser Asn Val Ala

85 90 95

Ala Gly Gly Asp Gly Arg Thr Ala Val Val Gly Gly Thr Ser Gly Pro 100 105 110 Ser Ala Thr Thr Ser Val Gly Thr Gin Thr Ser Gly Glu Phe Leu His 115 120 125

Gly Asn Pro Arg Thr Pro Glu Pro Gin Gly Pro Gin Ala Val Pro Pro

130 135 140

Pro Pro Pro Pro Pro Phe Pro Trp Gly His Glu Cys Cys Ala Arg Arg 145 150 155 160

Asp Arg Gly Ala Glu Lys Asp Val Gly Ala Ala Glu Ser Trp Ser Asp

165 170 175

Gly Pro Ser Ser Asp Ser Glu Thr Glu Asp Ser Asp Ser Ser Asp Glu 180 185 190 Asp Thr Gly Ser Gly Ser Glu Thr Leu Ser Arg Ser Ser Ser Ile Trp 195 200 205

Ala Ala Gly Ala Thr Asp Asp Asp Asp Ser Asp Ser Asp Ser Arg Ser 210 215 220 Asp Asp Ser Val Gin Pro Asp Val Val Val Arg Arg Arg Trp Ser Asp

225 230 235 240

Gly Pro Ala Pro Val Ala Phe .Pro Lys Pro Arg Arg Pro Gly Asp Ser

245 250 255 Pro Gly Asn Pro Gly Leu Gly Ala Gly Thr Gly Pro Gly Ser Ala Thr

260 265 270

Asp Pro Arg Ala Ser Ala Asp Ser Asp Ser Ala Ala His Ala Ala Ala

275 280 285

Pro Gin Ala Asp Val Ala Pro Val Leu Asp Ser Gin Pro Thr Val Gly 290 295 300

Thr Asp Pro Gly Tyr Pro Val Pro Leu Glu Leu Thr Pro Glu Asn Ala

305 310 315 320

Glu Ala Val Ala Arg Phe Leu Gly Asp Ala Val Asp Arg Glu Pro Ala

325 330 335 Leu Met Leu Glu Tyr Phe Cys Arg Cys Ala Arg Glu Glu Ser Lys Arg

340 345 350

Val Pro Pro Arg Thr Phe Gly Ser Ala Pro Arg Leu Thr Glu Asp Asp

355 360 365

Phe Gly Leu Leu Asn Tyr Ala Glu Met Arg Arg Leu Cys Leu Asp Leu 370 375 380

Pro Pro Val Pro Pro Asn Ala Tyr Thr Pro Tyr His Leu Arg Glu Tyr

385 390 395 400

Ala Thr Arg Leu Val Asn Gly Phe Lys Pro Leu Val Arg Arg Ser Ala

405 410 415 Arg Leu Tyr Arg Ile Leu Gly Ile Leu Val His Leu Arg Ile Arg Thr

420 425 430

Arg Glu Ala Ser Phe Glu Glu Trp Met Arg Ser Lys Glu Val Asp Leu

435 440 445

Asp Phe Gly Leu Thr Glu Arg Leu Arg Glu His Glu Ala Gin Leu Met 450 455 460

Ile Leu Ala Gin Ala Leu Asn Pro Tyr Asp Cys Leu Ile His Ser Thr

465 470 475 480

Pro Asn Thr Leu Val Glu Arg Gly Leu Gin Ser Ala Leu Lys Tyr Glu

485 490 495 Glu Phe Tyr Leu Lys Arg Phe Gly Gly His Tyr Met Glu Ser Val Phe

500 505 510

Gin Met Tyr Thr Arg Ile Ala Gly Phe Leu Ala Cys Arg Ala Thr Arg

515 520 525

Gly Met Arg His Ile Ala Leu Gly Arg Gin Gly Ser Trp Trp Glu Met 530 535 540

Phe Lys Phe Phe Phe His Arg Leu Tyr Asp His Gin Ile Val Pro Ser 545 550 555 560

Thr Pro Ala Met Leu Asn Leu Gly Thr Arg Asn Tyr Tyr Thr Ser Ser 565 570 575

Cys Tyr Leu Val Asn Pro Gin Ala Thr Thr Asn Gin Ala Thr Leu Arg

580 - 585 590

Ala Ile Thr Gly Asn Val Ser Ala Ile Leu Ala Arg Asn Gly Gly Ile 595 600 605

Gly Leu Cys Met Gin Ala Phe Asn Asp Asp Gly Thr Ala Ser Ile Met

610 615 620

Pro Ala Leu Lys Val Leu Asp Ser Leu Val Ala Ala His Asn Lys Gin 625 630 635 640 Ser Trp Thr Gly Ala Cys Val Tyr Leu Glu Pro Trp His Ser Asp Val

645 650 655

Arg Ala Val Leu Arg Met Lys Gly Val Leu Ala Gly Glu Glu Ala Gin

660 665 670

Arg Cys Asp Asn Ile Phe Ser Ala Leu Trp Met Pro Asp Leu Phe Phe 675 680 685

Lys Arg Leu Ile Arg His Leu Asp Gly Glu Lys Asn Val Thr Trp Ser

690 695 700

Leu Phe Asp Arg Asp Thr Ser Met Ser Leu Ala Asp Phe His Gly Glu 705 710 715 720 Glu Phe Glu Lys Leu Tyr Glu His Leu Glu Ala Met Gly Phe Gly Glu

725 730 735

Thr Ile Pro Ile Gin Asp Leu Ala Tyr Ala Ile Val Arg Ser Ala Ala

740 745 750

Thr Thr Gly Ser Pro Phe Ile Met Phe Lys Asp Ala Val Asn Arg His 755 760 765

Tyr Ile Tyr Asp Thr Gin Gly Ala Ala Ile Ala Gly Ser Asn Leu Cys

770 775 780

Thr Glu Ile Val His Pro Ser Ser Lys Arg Ser Ser Gly Val Cys Asn 785 790 795 800 Leu Gly Ser Val Asn Leu Ala Arg Cys Val Ser Arg Arg Thr Phe Asp

805 810 815

Phe Gly Met Leu Arg Asp Ala Val Gin Ala Cys Val Leu Met Val Asn

820 825 830

Ile Met Ile Asp Ser Thr Leu Gin Pro Thr Pro Gin Cys Arg His Asp 835 840 845

Asn Leu Arg Ser Met Gly Ile Gly Met Gin Gly Leu His Thr Ala Cys

850 855 860

Leu Lys Met Gly Leu Asp Leu Glu Ser Ala Glu Phe Arg Asp Leu Asn 865 870 875 880 Thr His Ile Ala Glu Val Met Leu Leu Ala Ala Met Lys Thr Ser Asn

885 890 895

Ala Leu Cys Val Arg Gly Ala Arg Pro Phe Ser His Phe Lys Arg Ser 900 905 910 Met Tyr Arg Ala Gly Arg Phe His Trp Glu Arg Phe Ser Asn Asp Arg

915 920 925

Tyr Glu Gly Glu Trp Glu Met eu Arg Gin Ser Met Met Lys His Gly

930 935 940 Leu Arg Asn Ser Gin Phe Ile Ala Leu Met Pro Thr Ala Ala Ser Ala

945 950 955 960

Gin Ile Ser Asp Val Ser Glu Gly Phe Ala Pro Leu Phe Thr Asn Leu

965 970 975

Phe Ser Lys Val Thr Arg Asp Gly Glu Thr Leu Arg Pro Asn Thr Leu 980 985 990

Leu Leu Lys Glu Leu Glu Arg Thr Phe Gly Gly Lys Arg Leu Leu Asp

995 1000 1005

Ala Met Asp Gly Leu Glu Ala Lys Gin Trp Ser Val Ala Gin Ala Leu

1010 1015 1020 Pro Cys Leu Asp Pro Ala His Pro Leu Arg Arg Phe Lys Thr Ala Phe

1025 1030 1035 104

Asp Tyr Asp Gin Glu Leu Leu Ile Asp Leu Cys Ala Asp Arg Ala Pro

1045 1050 1055

Tyr Val Asp His Ser Gin Ser Met Thr Leu Tyr Val Thr Glu Lys Ala 1060 1065 1070

Asp Gly Thr Leu Pro Ala Ser Thr Leu Val Arg Leu Leu Val His Ala

1075 1080 1085

Tyr Lys Arg Gly Leu Lys Thr Gly Met Tyr Tyr Cys Lys Val Arg Lys 1090 1095 1100 Ala Thr Asn Ser Gly Val Phe Ala Gly Asp Asp Asn Ile Val Cys Thr 1105 1110 1115 112

Ser Cys Ala Leu

(2) INFORMATION FOR SEQ ID NO: 255:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 333 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 255:

Met Asp Pro Ala Val Ser Pro Ala Ser Thr Asp Pro Leu Asp Thr His 1 5 10 15 Ala Ser Gly Ala Gly Ala Ala Pro Ile Pro Val Cys Pro Thr Pro Glu

20 25 30

Arg Tyr Phe Tyr Thr Ser Gin. Cys Pro Asp Ile Asn His Leu Arg Ser 35 40 45 Leu Ser Ile Leu Asn Arg Trp Leu Glu Thr Glu Leu Val Phe Val Gly 50 55 60

Asp Glu Glu Asp Val Ser Lys Leu Ser Glu Gly Glu Leu Gly Phe Tyr 65 70 75 80

Arg Phe Leu Phe Ala Phe Leu Ser Ala Ala Asp Asp Leu Val Thr Glu 85 90 95

Asn Leu Gly Gly Leu Ser Gly Leu Phe Glu Gin Lys Asp Ile Leu His

100 105 110

Tyr Tyr Val Glu Gin Glu Cys Ile Glu Val Val His Ser Arg Val Tyr 115 120 125 Asn Ile Ile Gin Leu Val Leu Phe His Asn Asn Asp Gin Ala Arg Arg 130 135 140

Ala Tyr Val Ala Arg Thr Ile Asn His Pro Ala Ile Arg Val Lys Val 145 150 155 160

Asp Trp Leu Glu Ala Arg Val Arg Glu Cys Asp Ser Ile Pro Glu Lys 165 170 175

Phe Ile Leu Met Ile Leu Ile Glu Gly Val Phe Phe Ala Ala Ser Phe

180 185 190

Ala Ala Ile Ala Tyr Leu Arg Thr Asn Asn Leu Leu Arg Val Thr Cys 195 200 205 Gin Ser Asn Asp Leu Ile Ser Arg Asp Glu Ala Val His Thr Thr Ala 210 215 220

Ser Cys Tyr Ile Tyr Asn Asn Tyr Leu Gly Gly His Ala Lys Pro Glu 225 230 235 240

Ala Ala Arg Val Tyr Arg Leu Phe Arg Glu Ala Val Asp Ile Glu Ile 245 250 255

Gly Phe Ile Arg Ser Gin Ala Pro Thr Asp Ser Ser Ile Leu Ser Pro

260 265 270

Gly Ala Ala Ile Glu Asn Tyr Val Arg Phe Ser Ala Asp Arg Leu Leu 275 280 285 Gly Leu Ile His Met Gin Pro Lys Ala Pro Ala Pro Asp Ala Ser Phe 290 295 300

Pro Leu Ser Leu Met Ser Thr Asp Lys His Thr Asn Phe Phe Glu Cys 305 310 315 320

Arg Ser Thr Ser Tyr Ala Gly Ala Val Val Asn Asp Leu 325 330

(2) INFORMATION FOR SEQ ID NO: 256: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 357 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 256:

Met Arg Arg Arg Gly His Ala Phe Ala Pro Gly Asp Arg Gly Thr Arg

1 5 10 15

Ala Ala Gly Pro Gly Pro Ala Ala Pro Trp Gly Ala Pro Ser Lys Pro 20 25 30 Ala Leu Arg Leu Ala His Leu Phe Cys Ile Arg Val Leu Arg Ala Leu 35 40 45

Gly Tyr Ala Tyr Ile Asn Ser Gly Gin Leu Glu Ala Asp Asp Ala Cys

50 55 60

Ala Asn Leu Tyr His Thr Asn Thr Val Ala Tyr Val His Thr Thr Asp 65 70 75 80

Thr Asp Leu Leu Leu Met Gly Cys Asp Ile Val Leu Asp Ile Ser Thr

85 90 95

Gly Tyr Ile Pro Thr Ile His Cys Arg Asp Leu Leu Gin Tyr Phe Lys 100 105 110 Met Ser Tyr Pro Gin Phe Leu Ala Leu Phe Val Arg Cys His Thr Asp 115 120 125

Leu His Pro Asn Asn Thr Tyr Ala Ser Val Glu Asp Val Leu Arg Glu

130 135 140

Cys His Trp Thr Ala Pro Ser Arg Ser Gin Ala Arg Arg Ala Ala Arg 145 150 155 160

Arg Glu Arg Ala Asn Ser Arg Ser Leu Glu Ser Met Pro Thr Leu Thr

165 170 175

Ala Ala Pro Val Gly Leu Glu Thr Arg Ile Ser Trp Thr Glu Ile Leu 180 185 190 Ala Gin Gin Ile Ala Gly Glu Asp Asp Tyr Glu Glu Asp Pro Pro Leu 195 200 205

Gin Pro Pro Asp Val Ala Gly Gly Pro Arg Asp Gly Ala Arg Ser Ser

210 215 220

Ser Ser Glu Ile Leu Thr Pro Pro Glu Leu Val Gin Val Pro Asn Ala 225 230 235 240

Gin Arg Val Ala Glu His Arg Gly Tyr Val Ala Gly Arg Arg Arg His

245 250 255

Val Ile His Asp Ala Pro Glu Ala Leu Asp Trp Leu Pro Asp Pro Met 260 265 270

Thr Ile Ala Glu Leu Val Glu His Arg Tyr Val Lys Tyr Val Ile Ser

275 .280 285

Leu Ile Ser Pro Lys Glu Arg Gly Pro Trp Thr Leu Leu Lys Arg Leu 290 295 300

Pro Ile Tyr Gin Asp Leu Arg Asp Glu Asp Leu Ala Arg Ser Ile Val 305 310 315 320

Thr Arg His Ile Thr Ala Pro Asp Ile Ala Asp Arg Phe Leu Ala Gin 325 330 335 Leu Trp Ala His Ala Pro Pro Pro Ala Phe Tyr Lys Asp Val Leu Ala 340 345 350

Lys Phe Trp Asp Glu 355

(2) INFORMATION FOR SEQ ID NO: 257:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 466 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:257:

Met Ala His Leu Pro Gly Gly Ala Ala Ala Ala Pro Leu Ser Glu Asp

1 5 10 15

Ala Ile Pro Ser Pro Arg Glu Arg Thr Glu Asp Trp Pro Pro Cys Gin 20 25 30

Ile Val Leu Gin Gly Ala Glu Leu Asn Gly Ile Leu Gin Ala Phe Ala

35 40 45

Pro Leu Arg Thr Ser Leu Leu Asp Ser Leu Leu Val Val Gly Asp Arg 50 55 60 Gly Ile Leu Val His Asn Ala Ile Phe Gly Glu Gin Val Phe Leu Pro 65 70 75 80

Leu Asp His Ser Gin Phe Ser Arg Tyr Arg Trp Gly Gly Pro Thr Ala

85 90 95

Ala Phe Leu Ser Leu Val Asp Gin Lys Arg Ser Leu Leu Ser Val Phe 100 105 110

Arg Ala Asn Gin Tyr Pro Asp Leu Arg Arg Val Glu Leu Thr Val Thr

115 120 125

Gly Gin Ala Pro Phe Arg Thr Leu Val Gin Arg Ile Trp Thr Thr Ala 130 135 140

Ser Asp Gly Glu Ala Val Glu Leu Ala Ser Glu Thr Leu Met Lys Arg 145 150 - 155 160

Glu Leu Thr Ser Phe Ala Val Leu Leu Pro Gin Gly Asp Pro Asp Val 165 170 175

Gin Leu Arg Leu Thr Lys Pro Gin Leu Thr Lys Val Val Asn Ala Val

180 185 190

Gly Asp Glu Thr Ala Lys Pro Thr Thr Phe Glu Leu Gly Pro Asn Gly 195 200 205 Lys Phe Ser Val Phe Asn Ala Arg Thr Cys Val Thr Phe Ala Ala Arg 210 215 220

Glu Glu Gly Ala Ser Ser Ser Thr Ser Ala Gin Val Gin Ile Leu Thr 225 230 235 240

Ser Ala Leu Lys Lys Ala Gly Gin Ala Ala Ala Asn Ala Lys Thr Val 245 250 255

Tyr Gly Glu Asn Thr Thr Phe Ser Val Val Val Asp Asp Cys Ser Met

260 265 270

Arg Ala Val Leu Arg Arg Leu Gin Val Gly Gly Gly Thr Leu Lys Phe 275 280 285 Phe Leu Thr Ala Asp Val Pro Ser Val Cys Val Thr Ala Thr Gly Pro 290 295 300

Asn Ala Val Ser Ala Val Phe Leu Leu Lys Pro Gin Arg Val Cys Leu 305 310 315 320

Asn Trp Leu Gly Arg Thr Pro Gly Ser Ser Thr Gly Ser Leu Ala Ser 325 330 335

Gin Asp Ser Arg Ala Gly Pro Thr Asp Ser Gin Asp Phe Ser Ser Glu

340 345 350

Pro Asp Ala Gly Asp Arg Gly Ala Pro Glu Glu Glu Gly Leu Glu Gly 355 360 365 Gin Ala Arg Val Pro Pro Ala Phe Pro Glu Pro Pro Gly Thr Lys Arg 370 375 380

Arg His Ala Gly Ala Glu Val Val Pro Ala Asp Asp Ala Thr Lys Arg 385 390 395 400

Pro Lys Thr Gly Val Pro Ala Ala Pro Thr Arg Ala Glu Ser Pro Pro 405 410 415

Leu Ser Ala Arg Tyr Gly Pro Glu Ala Ala Glu Gly Gly Gly Asp Gly

420 425 430

Gly Arg Tyr Ala Cys Tyr Phe Arg Asp Leu Gin Thr Gly Asp Asp Ser 435 440 445 Pro Leu Ser Ala Phe Arg Gly Pro Gin Arg Pro Pro Tyr Gly Phe Gly 450 455 460

Leu Pro 465 (2) INFORMATION FOR SEQ ID NO: 258:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 170 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 258:

Met Ala Phe Arg Ala Ser Gly Pro Ala Tyr Gin Pro Leu Ala Pro Ala 1 5 10 15

Asp Ala Arg Ala Arg Val Pro Ala Val Ala Trp Ile Gly Val Gly Ala

20 25 30

Ile Val Gly Ala Phe Ala Leu Val Ala Ala Leu Val Leu Val Pro Pro 35 40 45 Arg Ser Ser Trp Gly Leu Ser Pro Cys Asp Ser Gly Trp Gin Glu Phe 50 55 60

Asn Ala Gly Cys Val Ala Trp Asp Pro Thr Pro Val Glu His Glu Gin 65 70 75 80

Ala Val Gly Gly Cys Ser Ala Pro Ala Thr Leu Ile Pro Arg Ala Ala 85 90 95

Ala Lys His Leu Ala Ala Leu Thr Arg Val Gin Ala Glu Arg Ser Ser

100 105 110

Gly Tyr Trp Trp Val Asn Gly Asp Gly Ile Arg Thr Cys Leu Arg Leu 115 120 125 Val Asp Ser Val Ser Gly Ile Asp Glu Phe Cys Glu Glu Leu Ala Ile 130 135 140

Arg Ile Cys Tyr Tyr Pro Arg Ser Pro Gly Gly Phe Val Arg Phe Val 145 150 155 160

Thr Ser Ile Arg Asn Ala Leu Gly Leu Pro 165 170

(2) INFORMATION FOR SEQ ID NO: 259:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 713 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 259:

Met Gin Arg Arg Arg Ala Ser Ser Leu Arg Leu Ala Arg Cys Leu Thr

1 5 10 15

Pro Ala Asn Leu Ile Arg Gly Ala Asn Ala Gly Val Pro Glu Arg Arg 20 25 30 Ile Phe Ala Gly Cys Leu Leu Pro Thr Pro Glu Gly Leu Leu Ser Ala 35 40 45

Ala Val Gly Val Leu Arg Gin Arg Ala Asp Asp Leu Gin Pro Ala Phe

50 55 60

Leu Thr Gly Ala Asp Arg Ser Val Arg Leu Ala Ala Arg His His Asn 65 70 75 80

Thr Val Pro Glu Ser Leu Ile Val Asp Gly Leu Ala Ser Asp Pro His

85 90 95

Tyr Asp Tyr Ile Arg His Tyr Ala Ser Ala Ala Lys Gin Ala Leu Gly 100 105 110 Glu Val Glu Leu Ser Gly Gly Gin Leu Ser Arg Ala Ile Leu Ala Gin 115 120 125

Tyr Trp Lys Tyr Leu Gin Thr Val Val Pro Ser Gly Leu Asp Ile Pro

130 135 140

Asp Asp Pro Ala Gly Asp Cys Asp Pro Ser Leu His Val Leu Leu Arg 145 150 155 160

Pro Thr Leu Leu Pro Lys Leu Leu Val Arg Ala Pro Phe Lys Ser Gly

165 170 175

Ala Ala Ala Ala Lys Tyr Ala Ala Ala Val Ala Gly Leu Arg Asp Ala 180 185 190 Ala His Arg Leu Gin Gin Tyr Met Phe Phe Met Arg Pro Ala Asp Pro 195 200 205

Ser Arg Pro Ser Thr Asp Thr Ala Leu Arg Leu Ser Glu Phe Leu Ala

210 215 220

Tyr Val Ser Val Leu Tyr His Trp Ala Ser Trp Met Leu Trp Thr Ala 225 230 235 240

Asp Lys Tyr Val Cys Arg Arg Leu Gly Pro Ala Asp Arg Arg Phe Val

245 250 255

Ser Gly Ser Leu Glu Ala Pro Ala Glu Thr Phe Ala Arg His Leu Asp 260 265 270 Arg Gly Pro Ser Gly Thr Thr Gly Ser Met Gin Cys Met Ala Leu Arg 275 280 285

Ala Ala Val Ser Asp Val Leu Gly His Leu Thr Arg Leu Ala His Leu 290 295 300 Trp Glu Thr Gly Lys Arg Ser Gly Gly Thr Tyr Gly Ile Val Asp Ala

305 310 315 320

Ile Val Ser Thr Val Glu Val Leu Ser Ile Val His His His Ala Gin

325 330 335 Tyr Ile Ile Asn Ala Thr Leu Thr Gly Tyr Val Val Trp Ala Ser Asp

340 345 350

Ser Leu Asn Asn Glu Tyr Leu Arg Ala Ala Val Asp Ser Gin Glu Arg

355 360 365

Phe Cys Arg Thr Ala Ala Pro Leu Phe Pro Thr Met Thr Ala Pro Ser 370 375 380

Trp Ala Arg Met Glu Leu Ser Ile Lys Ser Trp Phe Gly Ala Ala Pro

385 390 395 400

Asp Leu Leu Arg Ser Gly Thr Pro Ser Pro His Tyr Glu Ser Ile Leu

405 410 415 Arg Leu Ala Ala Ser Gly Pro Pro Gly Gly Arg Gly Ala Val Gly Gly

420 425 430

Ser Cys Arg Asp Lys Ile Gin Arg Thr Arg Arg Asp Asn Ala Pro Pro

435 440 445

Pro Leu Pro Arg Ala Arg Pro His Ser Thr Pro Ala Ala Pro Arg Arg 450 455 460

Phe Arg Arg His Arg Glu Asp Leu Pro Glu Pro Pro His Val Asp Ala

465 470 475 480

Ala Asp Arg Gly Pro Glu Pro Cys Ala Gly Arg Pro Ala Thr Tyr Tyr

485 490 495 Thr His Met Ala Gly Ala Pro Pro Arg Leu Pro Pro Arg Asn Pro Ala

500 505 510

Pro Pro Glu Gin Arg Pro Ala Ala Ala Ala Arg Pro Leu Ala Ala Gin

515 520 525

Arg Glu Ala Ala Gly Val Tyr Asp Ala Val Arg Thr Trp Gly Pro Asp 530 535 540

Ala Glu Ala Glu Pro Asp Gin Met Glu Asn Thr Tyr Leu Leu Pro Asp

545 550 555 560

Asp Asp Ala Ala Met Pro Ala Gly Val Gly Leu Gly Ala Thr Pro Ala

565 570 575 Ala Asp Thr Thr Ala Ala Ala Trp Pro Ala Glu Ser His Ala Pro Arg

580 585 590

Ala Pro Ser Glu Asp Ala Asp Ser Ile Tyr Glu Ser Val Ser Glu Asp

595 600 605

Gly Gly Arg Val Tyr Glu Glu Ile Pro Trp Val Arg Val Tyr Glu Asn 610 615 620

Ile Cys Leu Arg Arg Gin Asp Ala Gly Gly Ala Ala Pro Pro Gly Asp 625 630 635 640

Ala Pro Asp Ser Pro Tyr Ile Glu Ala Glu Asn Pro Leu Tyr Asp Trp 645 650 655

Gly Gly Ser Ala Leu Phe Ser Pro Pro Gly Ala Thr Arg Ala Pro Asp

660 . 665 670

Pro Gly Leu Ser Leu Ser Pro Met Pro Ala Arg Pro Arg Thr Asn Ala

675 680 685

Asn Asp Gly Pro Thr Asn Val Ala Ala Leu Ser Ala Leu Leu Thr Lys

690 695 700

Leu Lys Arg Gly Arg His Gin Ser His 705 710

(2) INFORMATION FOR SEQ ID NO: 260:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 352 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 260:

Val Gly Ala Ala Ala Val Pro Leu Leu Ser Ala Gly Gly Ala Ala Pro 1 5 10 15 Pro His Pro Gly Pro Asp Ala Ala Val Phe Arg Ser Ser Leu Gly Ser 20 25 30

Leu Leu Tyr Trp Pro Gly Val Arg Ala Leu Leu Gly Arg Asp Cys Arg

35 40 45

Val Ala Ala Arg Tyr Ala Gly Arg Met Thr Tyr Ile Ala Thr Gly Ala 50 55 60

Leu Leu Ala Arg Phe Asn Pro Gly Ala Val Lys Cys Val Leu Pro Arg 65 70 75 80

Glu Ala Ala Phe Ala Gly Arg Val Leu Asp Val Leu Ala Val Leu Ala 85 90 95 Glu Gin Thr Val Gin Trp Leu Ser Val Val Val Gly Ala Arg Leu His 100 105 110

Pro His Ser Ala His Pro Ala Phe Val Asp Val Glu Gin Glu Ala Leu

115 120 125

Phe Arg Ala Leu Pro Leu Gly Ser Pro Gly Val Val Ala Ala Glu His 130 135 140

Glu Ala Leu Gly Asp Thr Ala Ala Arg Arg Leu Leu Ala Thr Ser Gin 145 150 155 160

Ala Val Leu Gly Ala Ala Val Tyr Ala Leu His Thr Ala Thr Val Thr 165 170 175

Leu Lys Tyr Ala Cys Gly Asp Ala Arg Arg Arg Arg Asp His Ala Ala

180 185 190

Ala Ala Arg Ala Val Leu Ala Thr Gly Leu Ile Leu Gin Arg Leu Leu 195 200 205

Gly Leu Ala Asp Thr Val Val Ala Cys Val Ala Ala Phe Asp Gly Gly

210 215 220

Ser Thr Ala Pro Glu Val Gly Thr Tyr Thr Pro Leu Arg Tyr Ala Cys 225 230 235 240 Val Leu Arg Ala Thr Gin Pro Leu Tyr Ala Arg Thr Thr Pro Ala Lys

245 250 255

Phe Trp Ala Asp Val Arg Ala Ala Ala Glu His Val Asp Leu Arg Pro

260 265 270

Ala Ser Ser Ala Pro Arg Ala Pro Val Ser Gly Thr Ala Asp Pro Ala 275 280 285

Phe Leu Leu Glu Asp Leu Ala Ala Phe Pro Pro Ala Pro Leu Asn Ser

290 295 300

Glu Ser Val Leu Gly Pro Arg Val Arg Val Val Asp Ile Met Ala Gin 305 310 315 320 Phe Arg Lys Leu Leu Met Gly Asp Glu Glu Thr Ala Ala Leu Arg Ala

325 330 335

His Val Ser Gly Arg Arg Ala Thr Gly Leu Gly Gly Pro Pro Arg Pro 340 345 350

(2) INFORMATION FOR SEQ ID NO: 261:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 457 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 261:

Met Ser Val Arg Gly His Ala Val Arg Arg Arg Arg Ala Ser Thr Arg

1 5 10 15

Ser His Ala Pro Ser Ala His Arg Ala Asp Ser Pro Val Glu Asp Glu 20 25 30

Pro Glu Gly Gly Gly Val Gly Leu Met Gly Tyr Leu Arg Ala Val Phe

35 40 45

Asn Val Asp Asp Asp Ser Glu Val Glu Ala Ala Gly Glu Met Ala Ser 50 55 60

Glu Glu Pro Pro Pro Arg Arg Arg Arg Glu Arg His Pro Gly Ser Arg 65 70 75 80

Arg Ala Ser Glu Ala Arg Ala Ala Ala Pro Pro Arg Arg Ala Ser Phe 85 90 95

Pro Arg Pro Arg Ser Val Thr Ala Arg Ser Gin Ser Val Arg Gly Arg 100 105 110

Arg Asp Ser Ala Ile Thr Arg Ala Pro Arg Gly Gly Tyr Leu Gly Pro 115 120 125 Met Asp Pro Arg Asp Val Leu Gly Arg Val Gly Gly Ser Arg Val Val 130 135 140

Pro Ser Pro Leu Phe Leu Asp Glu Leu Ser Tyr Glu Glu Asp Asp Tyr 145 150 155 160

Pro Ala Ala Val Ala His Asp Asp Gly Ala Gly Ala Arg Pro Pro Ala 165 170 175

Thr Val Glu Ile Leu Ala Gly Arg Val Ser Gly Pro Glu Leu Gin Ala 180 185 190

Ala Phe Pro Leu Asp Arg Leu Thr Pro Arg Val Ala Ala Trp Asp Glu 195 200 205 Ser Val Arg Ser Ala Leu Gly His Pro Ala Gly Phe Tyr Pro Cys Pro 210 215 220

Asp Ser Ala Phe Gly Leu Ser Arg Val Gly Val Met His Phe Asp Ala 225 230 235 240

Asp Pro Lys Val Phe Phe Arg Gin Thr Leu Gin Gin Gly Glu Ala Trp 245 250 255

Tyr Val Thr Gly Asp Ala Ile Leu Asp Leu Thr Asp Arg Arg Ala Lys 260 265 270

Thr Ser Pro Ser Arg Ala Met Gly Phe Leu Val Asp Ala Ile Val Arg 275 280 285 Val Ala Ile Asn Gly Trp Val Cys Gly Thr Arg Leu His Thr Glu Gly 290 295 300

Ala Arg Leu Gly Ala Arg Arg Gin Gly Gly Arg Ala Pro Thr Ala Val 305 310 315 320

Arg Glu Pro His Gly Val Ala Arg Gly Arg Arg Arg Ala Ala Ala Gin 325 330 335

Arg Gly Arg Gly Arg Ala Pro Pro Pro Arg Pro Arg Arg Arg Gly Leu 340 345 350

Ser Gin Phe Ala Gly Val Pro Ala Val Leu Arg Ala Arg Ala Pro Gly 355 360 365 Ala Arg Leu Ser Arg Gly Arg Pro Leu Arg Gly Ala His Asp Val His 370 375 380

Arg His Arg Gly Ser Ala Arg Pro Leu Gin Pro Arg Arg Arg Gin Met 385 390 395 400 Arg Ala Pro Ala Gly Gly Arg Val Cys Gly Ala Arg Pro Gly Arg Ala

405 410 415

Gly Gly Pro Gly Gly Ala Asp Gly Pro Val Gly Gly Arg Gly Gly Ala 420 425 430 Pro Ala Pro Ala Leu Arg Pro Pro Arg Val Cys Gly Arg Gly Ala Gly 435 440 445

Gly Ala Val Ser Arg Pro Ala Pro Gly 450 455

(2) INFORMATION FOR SEQ ID NO: 262:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 298 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 262:

Met Thr Ser Arg Arg Ser Val Lys Ser Cys Pro Arg Glu Ala Pro Arg

1 5 10 15

Gly Thr His Glu Glu Leu Tyr Tyr Gly Pro Val Ser Pro Ala Asp Pro 20 25 30

Glu Ser Pro Arg Asp Asp Phe Arg Arg Gly Ala Gly Pro Met Arg Ala

35 40 45

Arg Pro Arg Gly Glu Val Arg Phe Leu His Tyr Asp Glu Ala Gly Tyr 50 55 60 Ala Leu Tyr Arg Asp Ser Ser Ser Ser Glu Asp Asn Asp Glu Ser Arg 65 70 75 80

Asp Thr Ala Arg Pro Arg Arg Ser Ala Ser Val Ala Gly Ser His Gly

85 90 95

Pro Gly Pro Ala Arg Ala Pro Pro Pro Pro Gly Gly Pro Val Gly Ala 100 105 110

Gly Gly Arg Ser His Ala Pro Pro Ala Arg Thr Pro Lys Met Thr Arg

115 120 125

Gly Ala Pro Lys Ala Pro Ala Thr Pro Ala Thr Asp Pro Arg Arg Arg 130 135 140 Pro Ala Gin Ala Asp Ser Ala Val Leu Leu Asp Ala Pro Ala Pro Thr 145 150 155 160

Ala Ser Gly Arg Thr Lys Thr Pro Ala Gin Gly Leu Ala Lys Lys Leu 165 170 175 His Phe Ser Thr Ala Pro Pro Ser Pro Thr Ala Pro Trp Thr Pro Arg

180 185 190

Val Ala Gly Phe Asn Lys Arg Val Phe Cys Ala Ala Val Gly Arg Leu 195 200 205 Ala Ala Thr His Ala Arg Leu Ala Ala Val Gin Leu Trp Asp Met Ser 210 215 220

Arg Pro His Thr Asp Glu Asp Leu Asn Glu Leu Leu Asp Leu Thr Thr 225 230 235 240

Ile Arg Val Thr Val Cys Glu Gly Lys Asn Leu Leu Gin Arg Ala Asn 245 250 255

Glu Leu Val Asn Pro Asp Ala Ala Gin Asp Val Asp Ala Thr Ala Ala

260 265 270

Arg Arg Pro Ala Gly Arg Ala Ala Ala Thr Ala Arg Ala Pro Ala Arg 275 280 285 Ser Ala Ser Arg Pro Arg Arg Pro Leu Glu 290 295

(2) INFORMATION FOR SEQ ID NO: 263:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 70 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:263:

Val Val Leu Leu Phe Val Val Ala Gly Val Pro Gly Glu Pro Pro Asn 1 5 10 15

Ala Ala Gly Arg Val Ile Gly Asp Ala Gin Cys Arg Gly Asp Ser Ala

20 25 30

Gly Val Val Ser Val Pro Gly Val Leu Val Pro Phe Tyr Leu Gly Met 35 40 45

Thr Ser Met Gly Val Cys Met Ile Ala His Val Tyr Gin Ile Cys Gin

50 55 60

Arg Ala Ala Gly Ser Ala 65 70

(2) INFORMATION FOR SEQ ID NO: 264:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 363 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 264:

Met Ser Gin Trp Gly Pro Arg Ala Ile Leu Val Gin Thr Asp Ser Thr 1 5 10 15

Asn Arg Asn Ala Asp Gly Asp Trp Gin Ala Ala Val Ala Ile Arg Gly

20 25 30

Gly Gly Val Val Gin Leu Asn Met Val Asn Lys Arg Ala Val Asp Phe 35 40 45

Thr Pro Ala Glu Cys Gly Asp Ser Glu Trp Ala Val Gly Arg Val Ser

50 55 60

Leu Gly Leu Arg Met Ala Met Pro Arg Asp Phe Cys Ala Ile Ile His 65 70 75 80 Ala Pro Ala Val Ser Gly Pro Gly Pro His Val Met Leu Gly Leu Val

85 90 95

Asp Ser Gly Tyr Arg Gly Thr Val Leu Ala Val Val Val Ala Pro Asn

100 105 110

Gly Thr Arg Gly Phe Ala Pro Gly Ala Leu Arg Val Asp Val Thr Phe 115 120 125

Leu Asp Ile Arg Ala Thr Pro Pro Thr Leu Thr Glu Pro Ser Ser Leu

130 135 140

His Arg Phe Pro Gin Leu Ala Pro Ser Pro Leu Ala Gly Leu Arg Glu 145 150 155 160 Asp Pro Trp Leu Asp Gly Ala Thr Ala Gly Gly Ala Val Pro Ala Arg

165 170 175

Arg Arg Gly Gly Ser Leu Val Tyr Ala Gly Glu Leu Thr Gin Val Thr

180 185 190

Thr Glu His Gly Asp Cys Val His Glu Ala Pro Ala Phe Leu Pro Lys 195 200 205

Arg Glu Glu Asp Ala Gly Phe Asp Ile Leu Ile His Arg Ala Val Thr

210 215 220

Val Pro Ala Asn Gly Ala Thr Val Ile Gin Pro Ser Leu Arg Val Leu 225 230 235 240 Arg Ala Ala Asp Gly Pro Glu Ala Cys Tyr Val Leu Gly Arg Ser Ser

245 250 255

Leu Asn Arg Leu Leu Val Met Pro Thr Arg Trp Pro Ser Gly His Ala 260 265 270 Cys Ala Phe Val Val Cys Asn Leu Thr Gly Val Pro Val Thr Leu Gin

275 280 285

Ala Gly Ser Lys Val Ala Gin Leu Leu Val Ala Gly Thr His Ala Leu

290 295 300

Pro Trp Ile Pro Pro Asp Asn Ile His Glu Asp Gly Ala Phe Arg Ala 305 310 315 320

Tyr Pro Arg Gly Val Pro Asp Ala Thr Ala Thr Pro Arg Asp Pro Pro

325 330 335

Ile Leu Val Phe Thr Asn Glu Phe Asp Ala Asp Ala Pro Pro Ser Lys

340 345 350

Arg Gly Ala Gly Gly Phe Gly Ser Thr Gly Ile 355 360

(2) INFORMATION FOR SEQ ID NO: 265:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 236 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 265:

Met Ala Ser Leu Leu Gly Val Leu Cys Gly Trp Gly Trp Glu Glu Gin

1 5 10 15

Gin Tyr Glu Met Ile Arg Ala Ala Ala Pro Pro Ser Xaa Xaa Asp Pro 20 25 30 Arg Leu Gin Glu Ala Val Val Asn Ala Leu Leu Pro Ala Pro Ile Thr 35 40 45

Leu Asp Asp Ala Leu Glu Ser Leu Asp Asp Thr Arg Arg Leu Val Lys

50 55 60

Ala Arg Ala Arg Thr Tyr His Ala Cys Met Val Asn Leu Glu Arg Leu 65 70 75 80

Ala Arg His His Pro Gly Leu Glu Gly Ser Thr Ile Asp Gly Ala Val

85 90 95

Ala Ala His Arg Asp Lys Met Arg Arg Leu Ala Asp Thr Cys Met Ala 100 105 110 Thr Ile Leu Gin Met Tyr Met Ser Val Gly Ala Ala Asp Lys Ser Ala 115 120 125

Asp Val Leu Val Ser Gin Ala Ile Arg Ser Met Ala Glu Ser Asp Val 130 135 140 Val Met Glu Asp Val Ala Ile Ala Glu Arg Ala Leu Gly Leu Ser Thr 145 150 155 160

Ser Ala Gly Gly Thr Arg Thr Ala Gly Leu Gly Ala Thr Glu Ala Pro

165 ^" 170 175

Pro Gly Pro Thr Arg Ala Gin Ala Pro Glu Val Ala Ser Val Pro Val

180 185 190

Thr His Ala Gly Asp Arg Ser Pro Val Arg Pro Gly Pro Val Pro Pro

195 200 205

Ala Asp Pro Thr Pro Asp Pro Arg His Arg Thr Ser Ala Pro Lys Arg

210 215 220

Gin Ala Ser Ser Thr Glu Ala Pro Leu Leu Leu Ala 225 230 235

(2) INFORMATION FOR SEQ ID NO: 266:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 453 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 266:

Met Tyr Val Asn Arg Asn Glu Ile Phe Asn Ala Ala Val Thr Asn Ile

1 5 10 15

Ile Leu Asp Leu Asp Ile Ala Leu Lys Glu Pro Val Pro Phe Pro Arg 20 25 30 Leu His Glu Ala Leu Gly His Phe Arg Arg Gly Ala Ala Val Gin Leu 35 40 45

Leu Phe Pro Ala Ala Arg Val Asp Pro Asp Ala Tyr Pro Cys Tyr Phe

50 55 60

Phe Lys Ser Ala Cys Arg Pro Arg Ala Pro Pro Val Cys Ala Gly Asp 65 70 75 80

Gly Pro Ser Ala Gly Gly Asp Asp Gly Asp Gly Asp Trp Phe Pro Asp

85 90 95

Ala Gly Gly Asp Asp Gly Asp Glu Glu Trp Glu Glu Asp Thr Asp Pro 100 105 110 Met Asp Thr Thr His Gly Pro Leu Pro Asp Asp Glu Ala Ala Tyr Leu 115 120 125

Asp Leu Leu His Glu Gin Ile Pro Ala Ala Thr Pro Ser Glu Pro Asp 130 135 140 Ser Val Val Cys Ser Cys Ala Asp Lys Ile Gly Leu Arg Val Cys Leu

145 150 155 160

Pro Val Pro Ala Pro Tyr Val Val His Gly Ser Leu Thr Met Arg Gly

165 170 175 Val Ala Arg Val Ile Gin Gin Ala Val Leu Leu Asp Arg Asp Phe Val

180 185 190

Glu Ala Val Gly Ser His Val Lys Asn Phe Leu Leu Ile Asp Thr Gly

195 200 205

Val Tyr Ala His Gly His Ser Leu Arg Leu Pro Tyr Phe Ala Lys Ile 210 215 220

Gly Pro Asp Gly Ser Ala Cys Gly Arg Leu Leu Pro Val Phe Val Ile

225 230 235 240

Pro Pro Ala Cys Glu Asp Val Pro Ala Phe Val Ala Ala His Ala Asp

245 250 255 Pro Arg Arg Phe His Phe His Ala Pro Pro Met Phe Ser Ala Ala Pro

260 265 270

Arg Glu Ile Arg Val Leu His Ser Leu Gly Gly Asp Tyr Val Ser Phe

275 280 285

Phe Glu Lys Lys Ala Ser Arg Asn Ala Leu Glu His Phe Gly Arg Arg 290 295 300

Glu Thr Leu Thr Glu Val Leu Gly Arg Tyr Asp Val Arg Pro Asp Ala

305 310 315 320

Gly Glu Thr Val Glu Gly Phe Ala Ser Glu Leu Leu Gly Arg Ile Val

325 330 335 Ala Cys Ile Glu Ala His Phe Pro Glu His Ala Arg Glu Tyr Gin Ala

340 345 350

Val Ser Val Arg Arg Ala Val Ile Lys Asp Asp Trp Val Leu Leu Gin

355 360 365

Leu Ile Pro Gly Arg Gly Ala Leu Asn Gin Ser Leu Ser Cys Leu Arg 370 375 380

Phe Lys His Gly Arg Ala Ser Arg Ala Thr Ala Arg Thr Phe Leu Ala

385 390 395 400

Leu Ser Val Gly Thr Asn Asn Arg Leu Cys Ala Ser Leu Cys Gin Gin

405 410 415 Cys Phe Ala Thr Lys Cys Asp Asn Asn Arg Leu His Thr Leu Phe Thr

420 425 430

Val Asp Ala Gly Thr Pro Cys Ser Arg Ser Ala Pro Ser Ser Thr Ser

435 440 445

Arg Pro Ser Ser Ser 450

(2) INFORMATION FOR SEQ ID NO: 267: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 332 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 267:

Met Leu Ala Val Arg Ser Leu Gin His Leu Thr Thr Val Ile Phe Ile

1 5 10 15

Thr Ala Tyr Gly Leu Val Leu Ala Trp Tyr Ile Val Phe Gly Asp Leu 20 25 30 His Arg Cys Ile Tyr Ala Val Arg Pro Ala Gly Ala His Asn Asp Thr 35 40 45

Ala Leu Val Trp Met Lys Ile Asn Gin Thr Leu Leu Phe Leu Gly Pro

50 55 60

Pro Thr Ala Pro Pro Gly Gly Ala Trp Thr Pro His Ala His Val Cys 65 70 75 80

Tyr Ala Asn Ile Ile Glu Gly Arg Ala Val Ser Leu Pro Ala Ile Pro

85 90 95

Gly Ala Met Ser Arg Arg Val Met Asn Val His Glu Ala Val Asn Cys 100 105 110 Leu Glu Ala Leu Trp Asp Thr Gin Met Arg Leu Val Val Val Gly Trp 115 120 125

Phe Leu Tyr Leu Ala Phe Val His Gin Arg Arg Cys Met Phe Gly Val

130 135 140

Val Ser Pro Ala His Ser Met Val Ala Pro Ala Thr Tyr Leu Leu Asn 145 150 155 160

Tyr Ala Gly Arg Ile Val Ser Ser Val Phe Leu Gin Tyr Pro Tyr Thr

165 170 175

Lys Ile Thr Arg Leu Leu Cys Glu Leu Ser Val Gin Arg Gin Thr Leu 180 185 190 Val Gin Leu Phe Glu Ala Asp Pro Val Thr Phe Leu Tyr His Arg Pro 195 200 205

Ala Val Gly Val Ile Val Gly Cys Glu Leu Leu Leu Arg Phe Val Gly

210 215 220

Leu Ile Val Gly Thr Ala Leu Ile Ser Arg Gly Ala Cys Ala Ile Thr 225 230 235 240

Tyr Pro Leu Phe Leu Thr Ile Thr Thr Trp Cys Phe Val Ser Ile Ile

245 250 255

Ala Leu Thr Glu Leu Tyr Phe Ile Leu Arg Arg Asp Ser Ala Pro Lys 260 265 270

Asn Ala Glu Pro Ala Ala Pro Arg Gly Arg Ser Lys Gly Trp Ser Gly

275 280 285

Val Cys Gly Arg Cys Cys Ser Ile Ile Leu Ser Gly Ile Ala Val Arg

290 295 300

Leu Cys Tyr Ile Ala Val Val Ala Gly Val Val Leu Met Ala Leu Arg 305 310 315 320

Tyr Glu Gin Glu Ile Gin Arg Arg Leu Phe Asp Leu 325 330

(2) INFORMATION FOR SEQ ID NO: 268:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 117 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:26

Met Ile Gly Ala His Pro Gly Val Gly Gly Asp Leu Pro Ser Gly Leu 1 5 10 15 Pro Thr Tyr Ala Glu Ala Thr Ser Asp Arg Pro Pro Thr Tyr Ala Met 20 25 30

Val Met Ala Ala Cys Pro Thr Glu Pro Pro Gly Gly Ser Val Gly Pro

35 40 45

Ala Asp Gin Pro Arg Val Gin Ser Ser Arg Thr Trp Arg Pro Pro Leu 50 55 60

Val Asn Ser Arg Glu Leu Tyr Arg Ala Gin Arg Ala Ala Arg Cys Ala 65 70 75 80

Ser Ser Ser Asp Thr Pro Gin Ala Pro Gly Trp Cys Gly Gly Thr Cys 85 90 95 Arg His Ala Val Phe Gly Val Val Ala Val Val Val Val Ile Ile Leu 100 105 110

Ala Phe Leu Trp Arg 115

(2) INFORMATION FOR SEQ ID NO: 269:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 194 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 269:

Met His Leu Phe Cys Gin Cys Pro Leu Thr Asp Gly Gin Asp Leu Tyr 1 5 10 15

Leu Cys Pro Val Tyr Pro Arg Met His Gin Glu His Leu Val Cys Pro

20 25 30

Leu His Arg Leu Asp Asp Ala Arg Arg Arg Gly Arg Thr Ser Ala Ala 35 40 45 Trp Asp Glu Gly Leu Val Arg Ala Leu Thr His Ser Gly Gly Leu Met 50 55 60

Gly Cys Gly Gly Arg Ser Leu Thr Leu Ser Glu Thr Tyr Trp Gly His 65 70 75 80

Pro Leu Tyr Glu Lys Leu Val Pro Trp Asp His Pro Arg Asp Leu Lys 85 90 95

Val Pro Glu Ala Ser Ala Val Gly Thr Arg Ala Leu Val Pro Arg Gly

100 105 110

Arg Gly Arg Pro Leu Arg Gly Arg Pro Val Pro Leu Ile Pro Leu Asp 115 120 125 Cys Glu Pro Asn Asp Gly Leu Pro Phe Gly Gly Gly Trp Pro Gly Gly 130 135 140

Arg Leu Arg Gly Ala Pro Val Pro Leu His Pro Pro Pro Pro Ser Ala 145 150 155 160

Pro Pro Leu Ser Phe Thr Pro Thr Leu Thr Pro Pro Cys Leu Cys Arg 165 170 175

Gly Leu Ser Leu Cys Val Val Val Lys Gin Tyr Leu Lys Asp Arg Asn

180 185 190

Asn Phe

(2) INFORMATION FOR SEQ ID NO: 270:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 853 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 270:

Met Asn Val Ala Thr Cys Thr His Gin Thr His His Ala Ala Arg Ala 1 5 10 15

Pro Gly Ala Thr Ser Ala Pro Gly Ala Ala Ser Gly Asp Pro Leu Gly

20 25 30

Ala Arg Arg Pro Ile Gly Asp Asp Glu Cys Glu Gin Tyr Thr Ser Ser 35 40 45

Val Ser Leu Ala Arg Met Leu Tyr Gly Gly Asp Leu Ala Glu Trp Val

50 55 60

Pro Arg Val His Pro Lys Thr Thr Ile Glu Arg Gin Gin His Gly Pro 65 70 75 80 Val Thr Phe Pro Asp Ala Ser Ala Pro Thr Ala Arg Cys Val Thr Val

85 90 95

Val Arg Ala Pro Met Gly Ser Gly Lys Thr Thr Ala Leu Ile Arg Trp

100 105 110

Leu Gly Glu Ala Ile His Ser Pro Asp Thr Ser Val Leu Val Val Ser 115 120 125

Cys Arg Arg Ser Phe Thr Gin Thr Leu Ala Thr Arg Phe Ala Glu Ser

130 135 140

Gly Leu Pro Asp Phe Val Thr Tyr Phe Ser Ser Thr Asn Tyr Ile Met 145 150 155 160 Asn Asp Arg Pro Phe His Arg Leu Ile Val Gin Val Glu Ser Leu His

165 170 175

Arg Val Gly Pro Asn Leu Leu Asn Asn Tyr Asp Val Leu Val Leu Asp

180 185 190

Glu Val Met Ser Thr Leu Gly Gin Lys Pro Thr Met Gin Gin Leu Gly 195 200 205

Arg Val Asp Ala Leu Met Leu Arg Leu Leu Arg Thr Cys Pro Arg Ile

210 215 220

Ile Ala Met Asp Ala Thr Ala Asn Ala Gin Leu Val Asp Phe Leu Cys 225 230 235 240 Ser Leu Arg Gly Glu Lys Asn Val His Val Val Ile Gly Glu Tyr Ala

245 250 255

Met Pro Gly Phe Ser Ala Arg Arg Cys Leu Phe Leu Pro Arg Leu Gly

260 265 270

Pro Glu Val Leu Gin Ala Ala Leu Arg Pro Pro Gly Pro Ala Gly Gly 275 280 285

Ala Pro Pro Pro Asp Ala Pro Pro Asp Ala Thr Phe Phe Gly Glu Leu

290 295 300

Glu Ala Arg Leu Ala Gly Gly Asp Asn Val Cys Ile Phe Ser Ser Thr 305 310 315 320

Val Ser Phe Ala Glu Val Val Ala Arg Phe Cys Arg Gin Phe Thr Asp

325 330 335

Arg Val Leu Leu Leu His Ser Leu Thr Pro Pro Gly Asp Val Thr Thr 340 345 350

Trp Gly Arg Tyr Arg Val Val Ile Tyr Thr Thr Val Val Thr Val Gly

355 360 365

Leu Ser Phe Asp Pro Pro His Phe Asp Ser Met Phe Ala Tyr Val Lys

370 375 380 Pro Met Asn Tyr Gly Pro Asp Met Val Ser Val Tyr Gin Ser Leu Gly

385 390 395 400

Arg Val Arg Thr Leu Arg Lys Gly Glu Leu Leu Ile Tyr Met Asp Gly

405 410 415

Ser Gly Ala Arg Ser Glu Pro Val Phe Thr Pro Met Leu Leu Asn His 420 425 430

Val Val Ser Ala Ser Gly Gin Trp Pro Ala Gin Phe Ser Gin Val Thr

435 440 445

Asn Leu Leu Cys Arg Arg Phe Lys Gly Arg Cys Asp Ala Ser His Ala

450 455 460 Asp Ala Ala Gin Arg Ser Arg Ile Tyr Ser Lys Phe Arg Tyr Lys His

465 470 475 480

Tyr Phe Glu Arg Cys Thr Leu Ala Cys Leu Ala Asp Ser Leu Asn Ile

485 490 495

Leu His Met Leu Leu Thr Leu Asn Cys Met His Val Arg Phe Trp Gly 500 505 510

His Asp Ala Ala Leu Thr Pro Arg Asn Phe Cys Leu Phe Leu Arg Gly

515 520 525

Ile His Phe Asp Ala Leu Arg Ala Gin Arg Asp Leu Arg Glu Leu Arg

530 535 540 Cys Gin Asp Pro Asp Thr Ser Leu Ser Ala Gin Ala Ala Glu Thr Glu

545 550 555 560

Glu Val Gly Leu Phe Val Glu Lys Tyr Leu Arg Pro Asp Val Ala Pro

565 570 575

Ala Glu Val Val Met Arg Gin Ser Leu Val Gly Arg Thr Arg Phe Ile 580 585 590

Tyr Leu Val Leu Leu Glu Ala Cys Leu Arg Val Pro Met Ala Ala His

595 600 605

Ser Ser Ala Ile Phe Arg Arg Leu Tyr Asp His Tyr Ala Thr Gly Val 610 615 620 Ile Pro Thr Ile Asn Ala Ala Gly Glu Leu Glu Leu Val His Pro Thr 625 630 635 640

Leu Asn Val Ala Pro Val Trp Glu Leu Phe Arg Leu Cys Ser Thr Met 645 650 655 Ala Ala Cys Leu Gin Trp Asp Ser Met Ala Gly Gly Ser Gly Arg Thr

660 665 670

Phe Ser Pro Glu Asp Val Leu Glu Leu Leu Asn Pro His Tyr Asp Arg 675 680 685 Tyr Met Gin Leu Val Phe Glu Leu Gly His Cys Asn Val Thr Asp Gly 690 695 700

Pro Leu Leu Ser Glu Asp Ala Val Lys Arg Val Ala Asp Ala Leu Ser 705 710 715 720

Gly Cys Pro Pro Arg Gly Ser Val Ser Glu Thr Glu His Ala Leu Ser 725 730 735

Leu Phe Lys Ile Ile Trp Gly Glu Leu Phe Gly Val Gin Leu Ala Lys

740 745 750

Ser Thr Gin Thr Phe Pro Gly Ala Gly Arg Val Lys Asn Leu Thr Lys 755 760 765 Arg Ala Ile Val Glu Leu Leu Asp Ala His Arg Ile Asp His Ser Ala 770 775 780

Cys Arg Thr Gin Leu Tyr Ala Leu Leu Met Ala His Lys Arg Glu Phe 785 790 795 800

Ala Gly Ala Arg Phe Lys Leu Arg Ala Pro Ala Trp Gly Arg Cys Leu 805 810 815

Arg Thr His Ala Ser Gly Ala Gin Pro Asn Thr Asp Ile Ile Ala Ala

820 825 830

Leu Ser Glu Leu Pro Thr Glu Ala Trp Pro Met Met Gin Gly Ala Val 835 840 845 Asn Phe Ser Thr Leu 850

(2) INFORMATION FOR SEQ ID NO: 271:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 857 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 271:

Met Ala Glu Thr Met Asn Val Ala Thr Cys Thr His Gin Thr His His 1 5 10 15

Ala Ala Arg Ala Pro Gly Ala Thr Ser Ala Pro Gly Ala Ala Ser Gly 20 25 30 Asp Pro Leu Gly Ala Arg Arg Pro lie Gly Asp Asp Glu Cys Glu Gin

35 40 45

Tyr Thr Ser Ser Val Ser Leu Ala Arg Met Leu Tyr Gly Gly Asp Leu 50 55 60 Ala Glu Trp Val Pro Arg Val His Pro Lys Thr Thr Ile Glu Arg Gin 65 70 75 80

Gin His Gly Pro Val Thr Phe Pro Asp Ala Ser Ala Pro Thr Ala Arg

85 90 95

Cys Val Thr Val Val Arg Ala Pro Met Gly Ser Gly Lys Thr Thr Ala 100 105 110

Leu Ile Arg Trp Leu Gly Glu Ala Ile His Ser Pro Asp Thr Ser Val

115 120 125

Leu Val Val Ser Cys Arg Arg Ser Phe Thr Gin Thr Leu Ala Thr Arg

130 135 140 Phe Ala Glu Ser Gly Leu Pro Asp Phe Val Thr Tyr Phe Ser Ser Thr

145 150 155 160

Asn Tyr Ile Met Asn Asp Arg Pro Phe His Arg Leu Ile Val Gin Val

165 170 175

Glu Ser Leu His Arg Val Gly Pro Asn Leu Leu Asn Asn Tyr Asp Val 180 185 190

Leu Val Leu Asp Glu Val Met Ser Thr Leu Gly Gin Lys Pro Thr Met

195 200 205

Gin Gin Leu Gly Arg Val Asp Ala Leu Met Leu Arg Leu Leu Arg Thr

210 215 220 Cys Pro Arg Ile Ile Ala Met Asp Ala Thr Ala Asn Ala Gin Leu Val

225 230 235 240

Asp Phe Leu Cys Ser Leu Arg Gly Glu Lys Asn Val His Val Val Ile

245 250 255

Gly Glu Tyr Ala Met Pro Gly Phe Ser Ala Arg Arg Cys Leu Phe Leu 260 265 270

Pro Arg Leu Gly Pro Glu Val Leu Gin Ala Ala Leu Arg Pro Pro Gly

275 280 285

Pro Ala Gly Gly Ala Pro Pro Pro Asp Ala Pro Pro Asp Ala Thr Phe

290 295 300 Phe Gly Glu Leu Glu Ala Arg Leu Ala Gly Gly Asp Asn Val Cys Ile

305 310 315 320

Phe Ser Ser Thr Val Ser Phe Ala Glu Val Val Ala Arg Phe Cys Arg

325 330 335

Gin Phe Thr Asp Arg Val Leu Leu Leu His Ser Leu Thr Pro Pro Gly 340 345 350

Asp Val Thr Thr Trp Gly Arg Tyr Arg Val Val Ile Tyr Thr Thr Val

355 360 365

Val Thr Val Gly Leu Ser Phe Asp Pro Pro His Phe Asp Ser Met Phe 370 375 380

Ala Tyr Val Lys Pro Met Asn Tyr Gly Pro Asp Met Val Ser Val Tyr 385 390 _. 395 400

Gin Ser Leu Gly Arg Val Arg Thr Leu Arg Lys Gly Glu Leu Leu Ile 405 410 415

Tyr Met Asp Gly Ser Gly Ala Arg Ser Glu Pro Val Phe Thr Pro Met

420 425 430

Leu Leu Asn His Val Val Ser Ala Ser Gly Gin Trp Pro Ala Gin Phe 435 440 445 Ser Gin Val Thr Asn Leu Leu Cys Arg Arg Phe Lys Gly Arg Cys Asp 450 455 460

Ala Ser His Ala Asp Ala Ala Gin Arg Ser Arg Ile Tyr Ser Lys Phe 465 470 475 480

Arg Tyr Lys His Tyr Phe Glu Arg Cys Thr Leu Ala Cys Leu Ala Asp 485 490 495

Ser Leu Asn Ile Leu His Met Leu Leu Thr Leu Asn Cys Met His Val

500 505 510

Arg Phe Trp Gly His Asp Ala Ala Leu Thr Pro Arg Asn Phe Cys Leu 515 520 525 Phe Leu Arg Gly Ile His Phe Asp Ala Leu Arg Ala Gin Arg Asp Leu 530 535 540

Arg Glu Leu Arg Cys Gin Asp Pro Asp Thr Ser Leu Ser Ala Gin Ala 545 550 555 560

Ala Glu Thr Glu Glu Val Gly Leu Phe Val Glu Lys Tyr Leu Arg Pro 565 570 575

Asp Val Ala Pro Ala Glu Val Val Met Arg Gin Ser Leu Val Gly Arg

580 585 590

Thr Arg Phe Ile Tyr Leu Val Leu Leu Glu Ala Cys Leu Arg Val Pro 595 600 605 Met Ala Ala His Ser Ser Ala Ile Phe Arg Arg Leu Tyr Asp His Tyr 610 615 620

Ala Thr Gly Val Ile Pro Thr Ile Asn Ala Ala Gly Glu Leu Glu Leu 625 630 635 640

Val His Pro Thr Leu Asn Val Ala Pro Val Trp Glu Leu Phe Arg Leu 645 650 655

Cys Ser Thr Met Ala Ala Cys Leu Gin Trp Asp Ser Met Ala Gly Gly

660 665 670

Ser Gly Arg Thr Phe Ser Pro Glu Asp Val Leu Glu Leu Leu Asn Pro 675 680 685 His Tyr Asp Arg Tyr Met Gin Leu Val Phe Glu Leu Gly His Cys Asn 690 695 700

Val Thr Asp Gly Pro Leu Leu Ser Glu Asp Ala Val Lys Arg Val Ala 705 710 715 720 Asp Ala Leu Ser Gly Cys Pro Pro Arg Gly Ser Val Ser Glu Thr Glu

725 730 735

His Ala Leu Ser Leu Phe Lys Ile Ile Trp Gly Glu Leu Phe Gly Val 740 745 750 Gin Leu Ala Lys Ser Thr Gin Thr Phe Pro Gly Ala Gly Arg Val Lys 755 760 765

Asn Leu Thr Lys Arg Ala Ile Val Glu Leu Leu Asp Ala His Arg Ile

770 775 780

Asp His Ser Ala Cys Arg Thr Gin Leu Tyr Ala Leu Leu Met Ala His 785 790 795 800

Lys Arg Glu Phe Ala Gly Ala Arg Phe Lys Leu Arg Ala Pro Ala Trp

805 810 815

Gly Arg Cys Leu Arg Thr His Ala Ser Gly Ala Gin Pro Asn Thr Asp 820 825 830 Ile Ile Ala Ala Leu Ser Glu Leu Pro Thr Glu Ala Trp Pro Met Met 835 840 845

Gin Gly Ala Val Asn Phe Ser Thr Leu 850 855

(2) INFORMATION FOR SEQ ID NO: 272:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1370 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:272:

Met Glu Pro Ala Asn Pro Pro Arg Asn Pro Met Ala Ala Pro Ala Arg

1 5 10 15

Asp Pro Pro Gly Tyr Arg Tyr Ala Ala Ala Met Val Pro Thr Gly Ser 20 25 30

Ile Leu Ser Thr Ile Glu Val Ala Ser His Arg Arg Leu Phe Asp Phe

35 40 45

Phe Ala Arg Val Arg Ser Asp Glu Asn Ser Leu Tyr Asp Val Glu Phe 50 55 60 Asp Ala Leu Leu Gly Ser Tyr Cys Asn Thr Leu Ser Leu Val Arg Phe 65 70 75 80

Leu Glu Leu Gly Leu Ser Val Ala Cys Val Cys Thr Lys Phe Pro Glu 85 90 95 Leu Ala Tyr Met Asn Glu Gly Arg Val Gin Phe Glu Val His Gin Pro

100 105 110 Leu Ile Ala Arg Asp Gly Pro_. His Pro Val Glu Gin Pro Val His Asn 115 120 125 Tyr Met Thr Lys Val Ile Asp Arg Arg Ala Leu Asn Ala Ala Phe Ser 130 135 140

Leu Ala Thr Glu Ala lie Ala Leu Leu Thr Gly Glu Ala Leu Asp Gly 145 150 155 160

Thr Gly Ile Ser Leu His Arg Gin Leu Arg Ala Ile Gin Gin Leu Ala 165 170 175

Arg Asn Val Gin Ala Val Leu Gly Ala Phe Glu Arg Gly Thr Ala Asp

180 185 190 Gin Met Leu His Val Leu Leu Glu Lys Ala Pro Pro Leu Ala Leu Leu 195 200 205 Leu Pro Met Gin Arg Tyr Leu Asp Asn Gly Arg Leu Ala Thr Arg Val 210 215 220

Ala Arg Ala Thr Leu Val Ala Glu Leu Lys Arg Ser Phe Cys Asp Thr 225 230 235 240

Ser Phe Phe Leu Gly Lys Ala Gly His Arg Arg Glu Ala Ile Glu Ala 245 250 255

Trp Leu Val Asp Leu Thr Thr Ala Thr Gin Pro Ser Val Ala Val Pro

260 265 270 Arg Leu Thr His Ala Asp Thr Arg Gly Arg Pro Val Asp Gly Val Leu 275 280 285 Val Thr Thr Ala Ala Ile Lys Gin Arg Leu Leu Gin Ser Phe Leu Lys 290 295 300

Val Glu Asp Thr Glu Ala Asp Val Pro Val Thr Tyr Gly Glu Met Val 305 310 315 320

Leu Asn Gly Ala Asn Leu Val Thr Ala Leu Val Met Gly Lys Ala Val 325 330 335

Arg Ser Leu Asp Asp Val Gly Arg His Leu Leu Glu Met Gin Glu Glu

340 345 350 Gin Leu Glu Ala Asn Arg Glu Thr Leu Asp Glu Leu Glu Ser Ala Pro 355 360 365 Gin Thr Thr Arg Val Arg Ala Asp Leu Val Ala Ile Gly Asp Arg Leu 370 375 380

Val Phe Leu Glu Ala Leu Glu Lys Arg Ile Tyr Ala Ala Thr Asn Val 385 390 395 400

Pro Tyr Pro Leu Val Gly Ala Met Asp Leu Thr Phe Val Leu Pro Leu 405 410 415

Gly Leu Phe Asn Pro Ala Met Glu Arg Phe Ala Ala His Ala Gly Asp

420 425 430 Leu Val Pro Ala Pro Gly His Pro Glu Pro Arg Ala Phe Pro Pro Arg 435 440 445

Gin Leu Phe Phe Trp Gly Lys Asp His Gin Val Leu Arg Leu Ser Met

450 455_ 460

Glu Asn Ala Val Gly Thr Val Cys His Pro Ser Leu Met Asn Ile Asp 465 470 475 480

Ala Ala Val Gly Gly Val Asn His Asp Pro Val Glu Ala Ala Asn Pro

485 490 495

Tyr Gly Ala Tyr Val Ala Ala Pro Ala Gly Pro Gly Ala Asp Met Gin 500 505 510 Gin Arg Phe Leu Asn Ala Trp Arg Gin Arg Leu Ala His Gly Arg Val 515 520 525

Arg Trp Val Ala Glu Cys Gin Met Thr Ala Glu Gin Phe Met Gin Pro

530 535 540

Asp Asn Ala Asn Leu Ala Leu Glu Leu His Pro Ala Phe Asp Phe Phe 545 550 555 560

Ala Gly Val Ala Asp Val Glu Leu Pro Gly Gly Glu Val Pro Pro Ala

565 570 575

Gly Pro Gly Ala Ile Gin Ala Thr Trp Arg Val Val Asn Gly Asn Leu 580 585 590 Pro Leu Ala Leu Cys Pro Val Ala Phe Arg Asp Arg Leu Glu Leu Gly 595 600 605

Val Gly Arg His Ala Met Ala Pro Ala Thr Ile Ala Ala Val Arg Gly

610 615 620

Ala Phe Glu Asp Arg Ser Tyr Pro Ala Val Phe Tyr Leu Leu Gin Ala 625 630 635 640

Ala Ile His Gly Ser Glu His Val Phe Cys Ala Arg Leu Val Thr Gin

645 650 655

Cys Ile Thr Ser Tyr Trp Asn Asn Thr Arg Cys Ala Ala Phe Val Asn 660 665 670 Asp Tyr Ser Leu Val Ser Tyr Ile Val Thr Tyr Leu Gly Gly Asp Leu 675 680 685

Pro Glu Glu Cys Met Ala Val Tyr Arg Asp Leu Val Ala His Val Glu

690 695 700

Ala Gin Leu Val Asp Asp Phe Thr Leu Pro Gly Pro Glu Leu Gly Gly 705 710 715 720

Gin Ala Gin Ala Glu Leu Asn His Leu Met Arg Asp Pro Ala Leu Leu

725 730 735

Pro Pro Leu Val Trp Asp Cys Asp Gly Leu Met Arg His Ala Ala Leu 740 745 750 Asp Arg His Arg Asp Cys Arg Ile Asp Ala Gly Gly His Glu Pro Val 755 760 765

Tyr Ala Ala Ala Cys Asn Val Ala Thr Ala Asp Phe Asn Arg Asn Asp 770 775 780 Gly Arg Leu Leu His Asn Thr Gin Ala Arg Ala Ala Asp Ala Ala Asp

785 790 795 800

Asp Arg Pro His Arg Pro Ala_. Asp Trp Thr Val His His Lys Ile Tyr

805 810 815 Tyr Tyr Val Leu Val Pro Ala Phe Ser Arg Gly Arg Cys Cys Thr Ala

820 825 830

Gly Val Arg Phe Asp Arg Val Tyr Ala Thr Leu Gin Asn Met Val Val

835 840 845

Pro Glu Ile Ala Pro Gly Glu Glu Cys Pro Ser Asp Pro Val Thr Asp 850 855 860

Pro Ala His Pro Leu His Pro Ala Asn Leu Val Ala Asn Thr Val Asn

865 870 875 880

Ala Met Phe His Asn Gly Arg Val Val Val Asp Gly Pro Ala Met Leu

885 890 895 Thr Leu Gin Val Leu Ala His Asn Met Ala Glu Arg Thr Thr Ala Leu

900 905 910

Leu Cys Ser Ala Ala Pro Asp Ala Gly Ala Asn Thr Ala Ser Thr Ala

915 920 925

Asn Met Arg Ile Phe Asp Gly Ala Leu His Ala Gly Val Leu Leu Met 930 935 940

Ala Pro Gin His Leu Asp His Thr Ile Gin Asn Gly Glu Tyr Phe Tyr

945 950 955 960

Val Leu Pro Val His Ala Leu Phe Ala Gly Ala Asp His Val Ala Asn

965 970 975 Ala Pro Asn Phe Pro Pro Ala Leu Arg Asp Leu Ala Arg His Val Pro

980 985 990

Leu Val Pro Pro Ala Leu Gly Ala Asn Tyr Phe Ser Ser Ile Arg Gin

995 1000 1005

Pro Val Val Gin His Ala Arg Glu Ser Ala Ala Gly Glu Asn Ala Leu 1010 1015 1020

Thr Tyr Ala Leu Met Ala Gly Tyr Phe Lys Met Ser Pro Val Tyr His

1025 1030 1035 104

Gin Leu Lys Thr Gly Leu His Pro Gly Phe Gly Phe Thr Val Val Arg

1045 1050 1055 Gin Asp Arg Phe Val Thr Glu Asn Val Leu Phe Ser Ala Ser Glu Ala

1060 1065 1070

Tyr Phe Leu Gly Gin Leu Gin Val Ala Arg His Glu Thr Gly Gly Gly

1075 1080 1085

Val Ser Phe Thr Leu Thr Gin Pro Arg Gly Asn Val Asp Leu Gly Val 1090 1095 1100

Gly Tyr Thr Ala Val Ala Ala Thr Ala Thr Val Arg Asn Pro Val Thr 1105 1110 1115 112

Asp Met Gly Asn Leu Pro Gin Asn Phe Tyr Leu Gly Arg Gly Ala Pro 1125 1130 1135

Pro Leu Leu Asp Asn Ala Ala Ala Val Tyr Leu Arg Asn Ala Val Val

1140 . 1145 1150

Ala Gly Asn Arg Leu Gly Pro Ala Gin Pro Leu Pro Val Phe Gly Cys 1155 1160 1165

Ala Gin Val Pro Arg Arg Ala Gly Met Asp His Gly Gin Asp Ala Val

1170 1175 1180

Cys Glu Phe Ile Ala Thr Pro Val Ala Thr Asp Ile Asn Tyr Phe Arg 1185 1190 1195 120 Arg Pro Cys Asn Pro Arg Gly Arg Ala Ala Gly Gly Val Tyr Ala Gly

1205 1210 1215

Asp Lys Glu Gly Asp Val Ile Ala Leu Met Tyr Asp His Gly Gin Ser

1220 1225 1230

Asp Pro Ala Arg Pro Phe Ala Ala Thr Ala Asn Pro Trp Ala Ser Gin 1235 1240 1245

Arg Phe Ser Tyr Gly Asp Leu Leu Tyr Asn Gly Ala Tyr His Leu Asn

1250 1255 1260

Gly Asp Val Leu Ser Pro Cys Phe Lys Phe Phe Thr Ala Ala Asp Ile 1265 1270 1275 128 Thr Ala Lys His Arg Cys Leu Glu Arg Leu Ile Val Glu Thr Gly Ser

1285 1290 1295

Ala Val Ser Thr Ala Thr Ala Ala Ser Asp Val Gin Phe Lys Arg Pro

1300 1305 1310

Pro Gly Cys Arg Glu Leu Val Glu Asp Pro Cys Gly Leu Phe Gin Glu 1315 1320 1325

Ala Tyr Pro Ile Thr Cys Ala Ser Asp Pro Ala Leu Leu Arg Ser Ala

1330 1335 1340

Arg Asp Gly Glu Ala His Ala Arg Glu Thr His Phe Thr Gin Tyr Leu 1345 1350 1355 136 He Tyr Asp Asp Leu Lys Gly Leu Ser Leu

1365 1370

(2) INFORMATION FOR SEQ ID NO: 273:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1360 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 273 Met Ala Ala Pro Ala Arg Asp Pro Pro Gly Tyr Arg Tyr Ala Ala Ala

1 5 _. 10 15

Met Val Pro Thr Gly Ser Ile Leu Ser Thr Ile Glu Val Ala Ser His 20 25 30

Arg Arg Leu Phe Asp Phe Phe Ala Arg Val Arg Ser Asp Glu Asn Ser

35 40 45

Leu Tyr Asp Val Glu Phe Asp Ala Leu Leu Gly Ser Tyr Cys Asn Thr 50 55 60 Leu Ser Leu Val Arg Phe Leu Glu Leu Gly Leu Ser Val Ala Cys Val 65 70 75 80

Cys Thr Lys Phe Pro Glu Leu Ala Tyr Met Asn Glu Gly Arg Val Gin

85 90 95

Phe Glu Val His Gin Pro Leu Ile Ala Arg Asp Gly Pro His Pro Val 100 105 110

Glu Gin Pro Val His Asn Tyr Met Thr Lys Val Ile Asp Arg Arg Ala

115 120 125

Leu Asn Ala Ala Phe Ser Leu Ala Thr Glu Ala Ile Ala Leu Leu Thr

130 135 140 Gly Glu Ala Leu Asp Gly Thr Gly Ile Ser Leu His Arg Gin Leu Arg

145 150 155 160

Ala Ile Gin Gin Leu Ala Arg Asn Val Gin Ala Val Leu Gly Ala Phe

165 170 175

Glu Arg Gly Thr Ala Asp Gin Met Leu His Val Leu Leu Glu Lys Ala 180 185 190

Pro Pro Leu Ala Leu Leu Leu Pro Met Gin Arg Tyr Leu Asp Asn Gly

195 200 205

Arg Leu Ala Thr Arg Val Ala Arg Ala Thr Leu Val Ala Glu Leu Lys

210 215 220 Arg Ser Phe Cys Asp Thr Ser Phe Phe Leu Gly Lys Ala Gly His Arg

225 230 235 240

Arg Glu Ala Ile Glu Ala Trp Leu Val Asp Leu Thr Thr Ala Thr Gin

245 250 255

Pro Ser Val Ala Val Pro Arg Leu Thr His Ala Asp Thr Arg Gly Arg 260 265 270

Pro Val Asp Gly Val Leu Val Thr Thr Ala Ala Ile Lys Gin Arg Leu

275 280 285

Leu Gin Ser Phe Leu Lys Val Glu Asp Thr Glu Ala Asp Val Pro Val 290 295 300 Thr Tyr Gly Glu Met Val Leu Asn Gly Ala Asn Leu Val Thr Ala Leu 305 310 315 320

Val Met Gly Lys Ala Val Arg Ser Leu Asp Asp Val Gly Arg His Leu 325 330 335 Leu Glu Met Gin Glu Glu Gin Leu Glu Ala Asn Arg Glu Thr Leu Asp

340 345 350

Glu Leu Glu Ser Ala Pro Gin_. Thr Thr Arg Val Arg Ala Asp Leu Val 355 360 365 Ala Ile Gly Asp Arg Leu Val Phe Leu Glu Ala Leu Glu Lys Arg lie 370 375 380

Tyr Ala Ala Thr Asn Val Pro Tyr Pro Leu Val Gly Ala Met Asp Leu 385 390 395 400

Thr Phe Val Leu Pro Leu Gly Leu Phe Asn Pro Ala Met Glu Arg Phe 405 410 415

Ala Ala His Ala Gly Asp Leu Val Pro Ala Pro Gly His Pro Glu Pro

420 425 430

Arg Ala Phe Pro Pro Arg Gin Leu Phe Phe Trp Gly Lys Asp His Gin 435 440 445 Val Leu Arg Leu Ser Met Glu Asn Ala Val Gly Thr Val Cys His Pro 450 455 460

Ser Leu Met Asn Ile Asp Ala Ala Val Gly Gly Val Asn His Asp Pro 465 470 475 480

Val Glu Ala Ala Asn Pro Tyr Gly Ala Tyr Val Ala Ala Pro Ala Gly 485 490 495

Pro Gly Ala Asp Met Gin Gin Arg Phe Leu Asn Ala Trp Arg Gin Arg

500 505 510

Leu Ala His Gly Arg Val Arg Trp Val Ala Glu Cys Gin Met Thr Ala 515 520 525 Glu Gin Phe Met Gin Pro Asp Asn Ala Asn Leu Ala Leu Glu Leu His 530 535 540

Pro Ala Phe Asp Phe Phe Ala Gly Val Ala Asp Val Glu Leu Pro Gly 545 550 555 560

Gly Glu Val Pro Pro Ala Gly Pro Gly Ala Ile Gin Ala Thr Trp Arg 565 570 575

Val Val Asn Gly Asn Leu Pro Leu Ala Leu Cys Pro Val Ala Phe Arg

580 585 590

Asp Arg Leu Glu Leu Gly Val Gly Arg His Ala Met Ala Pro Ala Thr 595 600 605 Ile Ala Ala Val Arg Gly Ala Phe Glu Asp Arg Ser Tyr Pro Ala Val 610 615 620

Phe Tyr Leu Leu Gin Ala Ala Ile His Gly Ser Glu His Val Phe Cys 625 630 635 640

Ala Arg Leu Val Thr Gin Cys He Thr Ser Tyr Trp Asn Asn Thr Arg 645 650 655

Cys Ala Ala Phe Val Asn Asp Tyr Ser Leu Val Ser Tyr Ile Val Thr

660 665 670

Tyr Leu Gly Gly Asp Leu Pro Glu Glu Cys Met Ala Val Tyr Arg Asp 675 680 685

Leu Val Ala His Val Glu Ala Gin Leu Val Asp Asp Phe Thr Leu Pro

690 695- 700

Gly Pro Glu Leu Gly Gly Gin Ala Gin Ala Glu Leu Asn His Leu Met 705 710 715 720

Arg Asp Pro Ala Leu Leu Pro Pro Leu Val Trp Asp Cys Asp Gly Leu

725 730 735

Met Arg His Ala Ala Leu Asp Arg His Arg Asp Cys Arg Ile Asp Ala 740 745 750 Gly Gly His Glu Pro Val Tyr Ala Ala Ala Cys Asn Val Ala Thr Ala 755 760 765

Asp Phe Asn Arg Asn Asp Gly Arg Leu Leu His Asn Thr Gin Ala Arg

770 775 780

Ala Ala Asp Ala Ala Asp Asp Arg Pro His Arg Pro Ala Asp Trp Thr 785 790 795 800

Val His His Lys Ile Tyr Tyr Tyr Val Leu Val Pro Ala Phe Ser Arg

805 810 815

Gly Arg Cys Cys Thr Ala Gly Val Arg Phe Asp Arg Val Tyr Ala Thr 820 825 830 Leu Gin Asn Met Val Val Pro Glu Ile Ala Pro Gly Glu Glu Cys Pro 835 840 845

Ser Asp Pro Val Thr Asp Pro Ala His Pro Leu His Pro Ala Asn Leu

850 855 860

Val Ala Asn Thr Val Asn Ala Met Phe His Asn Gly Arg Val Val Val 865 870 875 880

Asp Gly Pro Ala Met Leu Thr Leu Gin Val Leu Ala His Asn Met Ala

885 890 895

Glu Arg Thr Thr Ala Leu Leu Cys Ser Ala Ala Pro Asp Ala Gly Ala 900 905 910 Asn Thr Ala Ser Thr Ala Asn Met Arg Ile Phe Asp Gly Ala Leu His 915 920 925

Ala Gly Val Leu Leu Met Ala Pro Gin His Leu Asp His Thr Ile Gin

930 935 940

Asn Gly Glu Tyr Phe Tyr Val Leu Pro Val His Ala Leu Phe Ala Gly 945 950 955 960

Ala Asp His Val Ala Asn Ala Pro Asn Phe Pro Pro Ala Leu Arg Asp

965 970 975

Leu Ala Arg His Val Pro Leu Val Pro Pro Ala Leu Gly Ala Asn Tyr 980 985 990 Phe Ser Ser Ile Arg Gin Pro Val Val Gin His Ala Arg Glu Ser Ala 995 1000 1005

Ala Gly Glu Asn Ala Leu Thr Tyr Ala Leu Met Ala Gly Tyr Phe Lys 1010 1015 1020 Met Ser Pro Val Tyr His Gin Leu Lys Thr Gly Leu His Pro Gly Phe

1025 1030 1035 104

Gly Phe Thr Val Val Arg Gin- Asp Arg Phe Val Thr Glu Asn Val Leu

1045 1050 1055 Phe Ser Ala Ser Glu Ala Tyr Phe Leu Gly Gin Leu Gin Val Ala Arg

1060 1065 1070

His Glu Thr Gly Gly Gly Val Ser Phe Thr Leu Thr Gin Pro Arg Gly

1075 1080 1085

Asn Val Asp Leu Gly Val Gly Tyr Thr Ala Val Ala Ala Thr Ala Thr 1090 1095 1100

Val Arg Asn Pro Val Thr Asp Met Gly Asn Leu Pro Gin Asn Phe Tyr

1105 1110 1115 112

Leu Gly Arg Gly Ala Pro Pro Leu Leu Asp Asn Ala Ala Ala Val Tyr

1125 1130 1135 Leu Arg Asn Ala Val Val Ala Gly Asn Arg Leu Gly Pro Ala Gin Pro

1140 1145 1150

Leu Pro Val Phe Gly Cys Ala Gin Val Pro Arg Arg Ala Gly Met Asp

1155 1160 1165

His Gly Gin Asp Ala Val Cys Glu Phe Ile Ala Thr Pro Val Ala Thr 1170 1175 1180

Asp Ile Asn Tyr Phe Arg Arg Pro Cys Asn Pro Arg Gly Arg Ala Ala

1185 1190 1195 120

Gly Gly Val Tyr Ala Gly Asp Lys Glu Gly Asp Val Ile Ala Leu Met

1205 1210 1215 Tyr Asp His Gly Gin Ser Asp Pro Ala Arg Pro Phe Ala Ala Thr Ala

1220 1225 1230

Asn Pro Trp Ala Ser Gin Arg Phe Ser Tyr Gly Asp Leu Leu Tyr Asn

1235 1240 1245

Gly Ala Tyr His Leu Asn Gly Asp Val Leu Ser Pro Cys Phe Lys Phe 1250 1255 1260

Phe Thr Ala Ala Asp Ile Thr Ala Lys His Arg Cys Leu Glu Arg Leu

1265 1270 1275 128

Ile Val Glu Thr Gly Ser Ala Val Ser Thr Ala Thr Ala Ala Ser Asp

1285 1290 1295 Val Gin Phe Lys Arg Pro Pro Gly Cys Arg Glu Leu Val Glu Asp Pro

1300 1305 1310

Cys Gly Leu Phe Gin Glu Ala Tyr Pro Ile Thr Cys Ala Ser Asp Pro

1315 1320 1325

Ala Leu Leu Arg Ser Ala Arg Asp Gly Glu Ala His Ala Arg Glu Thr 1330 1335 1340

His Phe Thr Gin Tyr Leu Ile Tyr Asp Asp Leu Lys Gly Leu Ser Leu 1345 1350 1355 136 ( 2 ) INFORMATION FOR SEQ ID NO : 274 :

( i ) SEQUENCE CHARACTERISTICS : (A) LENGTH : 604 amino acids ( B ) TYPE : amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 274:

Met Arg Pro Glu Leu Ser Leu Lys Gly Arg Pro Cys Val Thr Glu Ala 1 5 10 15 Val Val Cys Pro Ser Thr Asp Ala Ala Ile His Ser Gly Gly Ser Ser 20 25 30

Ser Val Arg Pro Gin Pro Tyr Ala Arg Ala Ala Arg Ala Arg Ala Thr

35 40 45

His Gly Ser Arg Ser Arg His Arg Gin Pro Leu Leu Pro Pro Pro Ser 50 55 60

Ser His His Pro Thr He Pro Pro Pro Pro Ser Pro Pro Arg Gly Ser 65 70 75 80

Pro Ala Met Glu Leu Ser Tyr Ala Thr Thr Leu His His Arg Asp Val 85 90 95 Val Phe Tyr Val Thr Ala Asp Arg Asn Arg Ala Tyr Phe Val Cys Gly 100 105 110

Gly Ser Val Tyr Ser Val Gly Arg Pro Arg Asp Ser Gin Pro Gly Glu

115 120 125

Ile Ala Lys Phe Gly Leu Val Val Arg Gly Thr Gly Pro Lys Asp Arg 130 135 140

Met Val Ala Asn Tyr Val Arg Ser Glu Leu Arg Gin Arg Gly Leu Arg

145 150 155 160

Asp Val Arg Pro Val Gly Glu Asp Glu Val Phe Leu Asp Ser Val Cys

165 170 175 Leu Leu Asn Pro Asn Val Ser Ser Asp Val Ile Asn Thr Asn Asp Val

180 185 190

Glu Val Leu Asp Glu Cys Leu Ala Glu Tyr Cys Thr Ser Leu Arg Thr

195 200 205

Ser Pro Gly Val Leu Val Thr Gly Val Arg Val Arg Ala Arg Asp Arg 210 215 220

Val Ile Glu Leu Phe Glu His Pro Ala Ile Val Asn Ile Ser Ser Arg 225 230 235 240

Phe Ala Tyr Thr Pro Ser Pro Tyr Val Phe Ala Gin Ala His Leu Pro 245 250 255

Arg Leu Pro Ser Ser Leu Glu Pro Leu Val Ser Gly Leu Phe Asp Gly

260 265 270

Ile Pro Ala Pro Arg Gin Pro Leu Asp Ala Arg Asp Arg Arg Thr Asp 275 280 285

Val Val Ile Thr Gly Thr Arg Ala Pro Arg Pro Met Ala Gly Thr Gly

290 295 300

Ala Gly Gly Ala Gly Ala Lys Arg Ala Thr Val Ser Glu Phe Val Gin 305 310 315 320 Val Lys His Ile Asp Arg Val Val Ser Pro Ser Val Ser Ser Ala Pro

325 330 335

Pro Pro Ser Ala Pro Asp Ala Ser Leu Pro Pro Pro Gly Leu Gin Glu

340 345 350

Ala Ala Pro Pro Gly Pro Pro Leu Arg Glu Leu Trp Trp Val Phe Tyr 355 360 365

Ala Gly Asp Arg Ala Leu Glu Glu Pro His Ala Glu Ser Gly Leu Thr

370 375 380

Arg Glu Glu Val Arg Ala Val His Gly Phe Arg Glu Gin Ala Trp Lys 385 390 395 400 Leu Phe Gly Ser Val Gly Ala Pro Arg Ala Phe Leu Gly Ala Ala Leu

405 410 415

Ser Pro Thr Gin Lys Leu Ala Val Tyr Tyr Tyr Leu Ile His Arg Glu

420 425 430

Arg Arg Met Ser Pro Phe Pro Ala Leu Val Arg Leu Val Gly Arg Tyr 435 440 445

Ile Gin Arg His Gly Val Pro Ala Pro Asp Glu Pro Thr Leu Ala Asp

450 455 460

Ala Met Asn Gly Leu Phe Arg Asp Ala Ala Gly Thr Val Ala Glu Gin 465 470 475 480 Leu Leu Met Phe Asp Leu Leu Pro Pro Lys Asp Val Pro Val Gly Ser

485 490 495

Asp Ala Arg Ala Asp Ser Ala Ala Leu Leu Arg Phe Val Asp Ser Gin

500 505 510

Arg Leu Thr Pro Gly Gly Ser Val Ser Pro Glu His Val Met Tyr Leu 515 520 525

Gly Ala Phe Leu Gly Val Leu Tyr Ala Gly His Gly Arg Leu Ala Ala

530 535 540

Ala Thr His Thr Ala Arg Leu Thr Gly Val Thr Ser Leu Val Leu Thr 545 550 555 560 Val Gly Asp Val Asp Arg Met Ser Ala Phe Asp Arg Gly Pro Ala Gly

565 570 575

Ala Ala Gly Arg Thr Arg Thr Ala Gly Tyr Leu Asp Ala Leu Leu Thr 580 585 590 Val Cys Leu Ala Arg Ala Gin His Gly Gin Ser Val 595 600

(2) INFORMATION FOR SEQ ID NO: 275:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 522 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 275:

Met Glu Leu Ser Tyr Ala Thr Thr Leu His His Arg Asp Val Val Phe

1 5 10 15

Tyr Val Thr Ala Asp Arg Asn Arg Ala Tyr Phe Val Cys Gly Gly Ser 20 25 30 Val Tyr Ser Val Gly Arg Pro Arg Asp Ser Gin Pro Gly Glu Ile Ala 35 40 45

Lys Phe Gly Leu Val Val Arg Gly Thr Gly Pro Lys Asp Arg Met Val

50 55 60

Ala Asn Tyr Val Arg Ser Glu Leu Arg Gin Arg Gly Leu Arg Asp Val 65 70 75 80

Arg Pro Val Gly Glu Asp Glu Val Phe Leu Asp Ser Val Cys Leu Leu

85 90 95

Asn Pro Asn Val Ser Ser Asp Val Ile Asn Thr Asn Asp Val Glu Val 100 105 110 Leu Asp Glu Cys Leu Ala Glu Tyr Cys Thr Ser Leu Arg Thr Ser Pro 115 120 125

Gly Val Leu Val Thr Gly Val Arg Val Arg Ala Arg Asp Arg Val lie

130 135 140

Glu Leu Phe Glu His Pro Ala Ile Val Asn Ile Ser Ser Arg Phe Ala 145 150 155 160

Tyr Thr Pro Ser Pro Tyr Val Phe Ala Gin Ala His Leu Pro Arg Leu

165 170 175

Pro Ser Ser Leu Glu Pro Leu Val Ser Gly Leu Phe Asp Gly Ile Pro 180 185 190 Ala Pro Arg Gin Pro Leu Asp Ala Arg Asp Arg Arg Thr Asp Val Val 195 200 205

Ile Thr Gly Thr Arg Ala Pro Arg Pro Met Ala Gly Thr Gly Ala Gly 210 215 220 Gly Ala Gly Ala Lys Arg Ala Thr Val Ser Glu Phe Val Gin Val Lys

225 230 235 240

His Ile Asp Arg Val Val Ser. Pro Ser Val Ser Ser Ala Pro Pro Pro

245 250 255 Ser Ala Pro Asp Ala Ser Leu Pro Pro Pro Gly Leu Gin Glu Ala Ala

260 265 270

Pro Pro Gly Pro Pro Leu Arg Glu Leu Trp Trp Val Phe Tyr Ala Gly

275 280 285

Asp Arg Ala Leu Glu Glu Pro His Ala Glu Ser Gly Leu Thr Arg Glu 290 295 300

Glu Val Arg Ala Val His Gly Phe Arg Glu Gin Ala Trp Lys Leu Phe

305 310 315 320

Gly Ser Val Gly Ala Pro Arg Ala Phe Leu Gly Ala Ala Leu Ser Pro

325 330 335 Thr Gin Lys Leu Ala Val Tyr Tyr Tyr Leu Ile His Arg Glu Arg Arg

340 345 350

Met Ser Pro Phe Pro Ala Leu Val Arg Leu Val Gly Arg Tyr Ile Gin

355 360 365

Arg His Gly Val Pro Ala Pro Asp Glu Pro Thr Leu Ala Asp Ala Met 370 375 380

Asn Gly Leu Phe Arg Asp Ala Ala Gly Thr Val Ala Glu Gin Leu Leu

385 390 395 400

Met Phe Asp Leu Leu Pro Pro Lys Asp Val Pro Val Gly Ser Asp Ala

405 410 415 Arg Ala Asp Ser Ala Ala Leu Leu Arg Phe Val Asp Ser Gin Arg Leu

420 425 430

Thr Pro Gly Gly Ser Val Ser Pro Glu His Val Met Tyr Leu Gly Ala

435 440 445

Phe Leu Gly Val Leu Tyr Ala Gly His Gly Arg Leu Ala Ala Ala Thr 450 455 460

His Thr Ala Arg Leu Thr Gly Val Thr Ser Leu Val Leu Thr Val Gly 465 470 475 480

Asp Val Asp Arg Met Ser Ala Phe Asp Arg Gly Pro Ala Gly Ala Ala 485 490 495 Gly Arg Thr Arg Thr Ala Gly Tyr Leu Asp Ala Leu Leu Thr Val Cys 500 505 510

Leu Ala Arg Ala Gin His Gly Gin Ser Val 515 520

(2) INFORMATION FOR SEQ ID NO: 276:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 602 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:276:

Met Thr Ala Ala Ala Leu Tyr Gly Gly Ala Lys Tyr Arg Pro Gly Thr 1 5 10 15

Leu Arg Asn Pro Gly Arg Val Ala Ser Thr Pro Arg Arg Arg Gly Val

20 25 30

Leu Tyr Gly Ala Leu Cys Pro Gly Ile Pro Phe Val Gly Ser Gly Pro 35 40 45 Gly Ala Val Gly Trp Glu Cys Val Cys Val Gly Gly Gly Arg Arg Asp 50 55 60

Gly Gly Pro Asp Gin Val Tyr Arg Gly Arg Ser Val Gly Arg Pro Asn 65 70 75 80

Arg Pro Phe Lys His Leu Arg Met His Arg Pro Ser Gin Ser Asp Thr 85 90 95

Gly Thr His Gin Arg Arg Lys Pro Pro Ser Pro Val Arg Val Arg Val

100 105 110

Phe Ser Gly Gly Val Phe Phe Leu Ser Ala Leu Leu Pro Pro His Leu 115 120 125 His His Pro Pro Pro Thr Trp Leu Ala Ile Gly Gly Lys Thr Met Lys 130 135 140

Thr Lys Pro Leu Pro Thr Ala Pro Met Ala Trp Ala Glu Ser Ala Val 145 150 155 160

Glu Thr Thr Thr Ser Pro Arg Glu Leu Ala Gly His Ala Pro Leu Arg 165 170 175

Arg Val Leu Arg Pro Pro Ile Ala Arg Arg Asp Gly Pro Val Leu Leu

180 185 190

Gly Asp Arg Ala Pro Arg Arg Thr Ala Ser Thr Met Trp Leu Leu Gly 195 200 205 Ile Asp Pro Ala Glu Ser Ser Pro Gly Thr Arg Ala Thr Arg Asp Asp 210 215 220

Thr Glu Gin Ala Val Asp Lys Ile Leu Arg Gly Ala Arg Arg Ala Gly 225 230 235 240

Gly Leu Thr Val Pro Gly Ala Pro Arg Tyr His Leu Thr Arg Gin Val 245 250 255

Thr Leu Thr Asp Leu Cys Gin Pro Asn Ala Glu Arg Ala Gly Ala Leu

260 265 270

Leu Leu Ala Leu Arg His Pro Thr Asp Leu Pro His Leu Ala Arg His 275 280 285

Arg Ala Pro Pro Gly Arg Gin Thr Glu Arg Leu Ala Glu Ala Trp Gly

290 295. 300

Gin Leu Leu Glu Ala Ser Ala Leu Gly Ser Gly Arg Ala Glu Ser Gly 305 310 315 320

Cys Ala Arg Ala Gly Leu Val Ser Phe Asn Phe Leu Val Ala Ala Cys

325 330 335

Ala Ala Ala Tyr Asp Ala Arg Asp Ala Ala Glu Ala Val Arg Ala His 340 345 350 lie Thr Thr Asn Tyr Gly Gly Thr Arg Ala Gly Ala Arg Leu Asp Arg 355 360 365

Phe Ser Glu Cys Leu Arg Ala Met Val His Thr His Val Phe Phe Val

370 375 380

Met Arg Phe Phe Gly Gly Leu Val Ser Trp Val Thr Gin Asp Glu Leu 385 390 395 400

Ala Ser Val Thr Ala Val Cys Ser Gly Pro Gin Glu Ala Thr His Thr

405 410 415

Gly His Pro Gly Arg Pro Cys Ser Ala Val Thr Ile Pro Ala Cys Ala 420 425 430 Phe Val Asp Leu Asp Ala Glu Leu Cys Leu Gly Gly Pro Gly Ala Ala 435 440 445

Phe Leu Tyr Leu Val Phe Tyr Gin Cys Arg Asp Gin Glu Leu Cys Cys

450 455 460

Val Tyr Val Val Lys Ser Gin Leu Pro Pro Arg Gly Leu Glu Ala Ala 465 470 475 480

Leu Glu Arg Leu Phe Gly Arg Leu Arg Ile Thr Asn Thr Ile His Gly

485 490 495

Ala Glu Asp Met Thr Pro Pro Pro Pro Asn Arg Asn Val Asp Phe Pro 500 505 510 Leu Ala Val Leu Ala Ala Ser Ser Gin Ser Pro Arg Cys Ser Ala Ser 515 520 525

Gin Val Thr Asn Pro Gin Phe Val Asp Arg Leu Tyr Arg Trp Gin Pro

530 535 540

Asp Leu Arg Gly Arg Pro Thr Ala Arg Thr Cys Thr Tyr Ala Ala Phe 545 550 555 560

Ala Glu Leu Gly Val Met Pro Asp Asn Ser Pro Arg Cys Leu His Arg

565 570 575

Thr Glu Arg Phe Gly Ala Val Gly Val Pro Val Val Ile Gly Val Val 580 585 590 Trp Arg Pro Gly Gly Trp Arg Ala Cys Ala 595 600

(2) INFORMATION FOR SEQ ID NO: 277: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 515 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 277:

Met His Arg Pro Ser Gin Ser Asp Thr Gly Thr His Gin Arg Arg Lys

1 5 10 15

Pro Pro Ser Pro Val Arg Val Arg Val Phe Ser Gly Gly Val Phe Phe 20 25 30

Leu Ser Ala Leu Leu Pro Pro His Leu His His Pro Pro Pro Thr Trp

35 40 45

Leu Ala Ile Gly Gly Lys Thr Met Lys Thr Lys Pro Leu Pro Thr Ala 50 55 60 Pro Met Ala Trp Ala Glu Ser Ala Val Glu Thr Thr Thr Ser Pro Arg 65 70 75 80

Glu Leu Ala Gly His Ala Pro Leu Arg Arg Val Leu Arg Pro Pro lie

85 90 95

Ala Arg Arg Asp Gly Pro Val Leu Leu Gly Asp Arg Ala Pro Arg Arg 100 105 110

Thr Ala Ser Thr Met Trp Leu Leu Gly Ile Asp Pro Ala Glu Ser Ser

115 120 125

Pro Gly Thr Arg Ala Thr Arg Asp Asp Thr Glu Gin Ala Val Asp Lys

130 135 140 Ile Leu Arg Gly Ala Arg Arg Ala Gly Gly Leu Thr Val Pro Gly Ala

145 150 155 160

Pro Arg Tyr His Leu Thr Arg Gin Val Thr Leu Thr Asp Leu Cys Gin

165 170 175

Pro Asn Ala Glu Arg Ala Gly Ala Leu Leu Leu Ala Leu Arg His Pro 180 185 190

Thr Asp Leu Pro His Leu Ala Arg His Arg Ala Pro Pro Gly Arg Gin

195 200 205

Thr Glu Arg Leu Ala Glu Ala Trp Gly Gin Leu Leu Glu Ala Ser Ala 210 215 220 Leu Gly Ser Gly Arg Ala Glu Ser Gly Cys Ala Arg Ala Gly Leu Val 225 230 235 240

Ser Phe Asn Phe Leu Val Ala Ala Cys Ala Ala Ala Tyr Asp Ala Arg 245 250 255 Asp Ala Ala Glu Ala Val Arg Ala His Ile Thr Thr Asn Tyr Gly Gly 260 265 270

Thr Arg Ala Gly Ala Arg Leu. Asp Arg Phe Ser Glu Cys Leu Arg Ala 275 280 285

Met Val His Thr His Val Phe Phe Val Met Arg Phe Phe Gly Gly Leu 290 295 300

Val Ser Trp Val Thr Gin Asp Glu Leu Ala Ser Val Thr Ala Val Cys

305 310 315 320

Ser Gly Pro Gin Glu Ala Thr His Thr Gly His Pro Gly Arg Pro Cys

325 330 335

Ser Ala Val Thr Ile Pro Ala Cys Ala Phe Val Asp Leu Asp Ala Glu 340 345 350

Leu Cys Leu Gly Gly Pro Gly Ala Ala Phe Leu Tyr Leu Val Phe Tyr

355 360 365

Gin Cys Arg Asp Gin Glu Leu Cys Cys Val Tyr Val Val Lys Ser Gin 370 375 380

Leu Pro Pro Arg Gly Leu Glu Ala Ala Leu Glu Arg Leu Phe Gly Arg

385 390 395 400

Leu Arg Ile Thr Asn Thr Ile His Gly Ala Glu Asp Met Thr Pro Pro 405 410 415

Pro Pro Asn Arg Asn Val Asp Phe Pro Leu Ala Val Leu Ala Ala Ser 420 425 430

Ser Gin Ser Pro Arg Cys Ser Ala Ser Gin Val Thr Asn Pro Gin Phe 435 440 445

Val Asp Arg Leu Tyr Arg Trp Gin Pro Asp Leu Arg Gly Arg Pro Thr

450 455 460

Ala Arg Thr Cys Thr Tyr Ala Ala Phe Ala Glu Leu Gly Val Met Pro

465 470 475 480

Asp Asn Ser Pro Arg Cys Leu His Arg Thr Glu Arg Phe Gly Ala Val 485 490 495

Gly Val Pro Val Val Ile Gly Val Val Trp Arg Pro Gly Gly Trp Arg 500 505 510

Ala Cys Ala 515

(2) INFORMATION FOR SEQ ID NO: 278:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 460 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 278:

Met Lys Thr Lys Pro Leu Pro Thr Ala Pro Met Ala Trp Ala Glu Ser 1 5 10 15

Ala Val Glu Thr Thr Thr Ser Pro Arg Glu Leu Ala Gly His Ala Pro

20 25 30

Leu Arg Arg Val Leu Arg Pro Pro Ile Ala Arg Arg Asp Gly Pro Val 35 40 45

Leu Leu Gly Asp Arg Ala Pro Arg Arg Thr Ala Ser Thr Met Trp Leu

50 55 60

Leu Gly Ile Asp Pro Ala Glu Ser Ser Pro Gly Thr Arg Ala Thr Arg 65 70 75 80 Asp Asp Thr Glu Gin Ala Val Asp Lys Ile Leu Arg Gly Ala Arg Arg

85 90 95

Ala Gly Gly Leu Thr Val Pro Gly Ala Pro Arg Tyr His Leu Thr Arg

100 105 110

Gin Val Thr Leu Thr Asp Leu Cys Gin Pro Asn Ala Glu Arg Ala Gly 115 120 125

Ala Leu Leu Leu Ala Leu Arg His Pro Thr Asp Leu Pro His Leu Ala

130 135 140

Arg His Arg Ala Pro Pro Gly Arg Gin Thr Glu Arg Leu Ala Glu Ala 145 150 155 160 Trp Gly Gin Leu Leu Glu Ala Ser Ala Leu Gly Ser Gly Arg Ala Glu

165 170 175

Ser Gly Cys Ala Arg Ala Gly Leu Val Ser Phe Asn Phe Leu Val Ala

180 185 190

Ala Cys Ala Ala Ala Tyr Asp Ala Arg Asp Ala Ala Glu Ala Val Arg 195 200 205

Ala His Ile Thr Thr Asn Tyr Gly Gly Thr Arg Ala Gly Ala Arg Leu

210 215 220

Asp Arg Phe Ser Glu Cys Leu Arg Ala Met Val His Thr His Val Phe 225 230 235 240 Phe Val Met Arg Phe Phe Gly Gly Leu Val Ser Trp Val Thr Gin Asp

245 250 255

Glu Leu Ala Ser Val Thr Ala Val Cys Ser Gly Pro Gin Glu Ala Thr

260 265 270

His Thr Gly His Pro Gly Arg Pro Cys Ser Ala Val Thr Ile Pro Ala 275 280 285

Cys Ala Phe Val Asp Leu Asp Ala Glu Leu Cys Leu Gly Gly Pro Gly

290 295 300

Ala Ala Phe Leu Tyr Leu Val Phe Tyr Gin Cys Arg Asp Gin Glu Leu 305 310 315 320

Cys Cys Val Tyr Val Val Lys Ser Gin Leu Pro Pro Arg Gly Leu Glu

325 . 330 335

Ala Ala Leu Glu Arg Leu Phe Gly Arg Leu Arg Ile Thr Asn Thr Ile 340 345 350

His Gly Ala Glu Asp Met Thr Pro Pro Pro Pro Asn Arg Asn Val Asp

355 360 365

Phe Pro Leu Ala Val Leu Ala Ala Ser Ser Gin Ser Pro Arg Cys Ser

370 375 380 Ala Ser Gin Val Thr Asn Pro Gin Phe Val Asp Arg Leu Tyr Arg Trp

385 390 395 400

Gin Pro Asp Leu Arg Gly Arg Pro Thr Ala Arg Thr Cys Thr Tyr Ala

405 410 415

Ala Phe Ala Glu Leu Gly Val Met Pro Asp Asn Ser Pro Arg Cys Leu 420 425 430

His Arg Thr Glu Arg Phe Gly Ala Val Gly Val Pro Val Val Ile Gly

435 440 445

Val Val Trp Arg Pro Gly Gly Trp Arg Ala Cys Ala 450 455 460

(2) INFORMATION FOR SEQ ID NO: 279:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 452 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 279

Met Ala Val Val Cys Gly Ser Gly Leu Arg Leu Arg Pro Phe His Pro 1 5 10 15 Pro Ser Pro Ser Phe Phe Val Leu Arg Ala Leu Ile Arg Ala Gly Pro 20 25 30

Gly Pro Phe Ala Asp Arg Ala Pro Ser Gly Pro Gly Cys Gly Met Cys

35 40 45

Arg Gly Asp Ser Pro Gly Val Ala Gly Gly Ser Gly Glu His Cys Leu 50 55 60

Gly Gly Asp Asp Gly Asp Asp Gly Arg Pro Arg Leu Ala Cys Val Gly 65 70 75 80

Ala Ile Arg Phe Ala His Leu Trp Leu Gin Ala Thr Thr Leu Gly Phe 85 90 95

Val Gly Ser Val Val Leu Ser Arg Gly Pro Tyr Ala Asp Ala Met Ser

100 - 105 110

Gly Ala Phe Val Ile Gly Ser Thr Gly Leu Gly Phe Leu Arg Ala Pro 115 120 125

Pro Ala Phe Ala Arg Pro Pro Thr Arg Val Cys Ala Trp Leu Arg Leu

130 135 140

Val Gly Gly Gly Ala Ala Val Trp Ser Leu Gly Glu Ala Gly Ala Pro 145 150 155 160 Pro Gly Val Pro Gly Pro Ala Thr Gin Cys Leu Ala Leu Gly Ala Ala

165 170 175

Tyr Ala Ala Leu Leu Val Leu Ala Asp Asp Val His Pro Leu Phe Leu

180 185 190

Leu Ala Pro Arg Pro Leu Phe Val Gly Thr Leu Gly Val Val Val Gly 195 200 205

Gly Leu Thr Ile Gly Gly Ser Ala Arg Tyr Trp Trp Ile Asp Pro Arg

210 215 220

Ala Ala Ala Ala Leu Thr Ala Ala Val Val Ala Gly Leu Gly Thr Thr 225 230 235 240 Ala Ala Gly Asp Ser Phe Ser Lys Ala Cys Pro Arg His Arg Arg Phe

245 250 255

Cys Val Val Ser Ala Val Glu Ser Pro Pro Pro Arg Tyr Ala Pro Glu

260 265 270

Asp Ala Glu Arg Pro Thr Asp His Gly Pro Leu Leu Pro Ser Thr His 275 280 285

His Gin Arg Ser Pro Arg Val Cys Gly Asp Gly Ala Ala Arg Pro Glu

290 295 300

Asn Ile Trp Val Pro Val Val Thr Phe Ala Gly Ala Leu Ala Ala Cys 305 310 315 320 Ala Arg Ser Asp Ala Ala Pro Ser Gly Pro Val Leu Pro Leu Trp Pro

325 330 335

Gin Val Phe Val Gly Gly His Ala Ala Ala Gly Leu Thr Glu Leu Cys

340 345 350

Gin Thr Leu Ala Pro Arg Asp Leu Thr Asp Pro Leu Leu Phe Ala Tyr 355 360 365

Val Gly Phe Gin Val Val Asn His Gly Leu Met Phe Val Val Pro Asp

370 375 380

Ile Ala Val Tyr Ala Met Leu Gly Gly Ala Val Trp Ile Ser Leu Thr 385 390 395 400 Gin Val Leu Gly Leu Arg Arg Arg Leu His Lys Asp Pro Asp Ala Gly

405 410 415

Pro Trp Ala Ala Ala Thr Leu Arg Gly Leu Phe Phe Ser Val Tyr Ala 420 425 430 Leu Gly Phe Ala Ala Gly Val Leu Val Arg Pro Arg Met Ala Ala Ser

435 440 445

Arg Arg Ser Gly 450

(2) INFORMATION FOR SEQ ID NO: 280:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 406 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 280:

Met Cys Arg Gly Asp Ser Pro Gly Val Ala Gly Gly Ser Gly Glu His

1 5 10 15

Cys Leu Gly Gly Asp Asp Gly Asp Asp Gly Arg Pro Arg Leu Ala Cys

20 25 30

Val Gly Ala Ile Arg Phe Ala His Leu Trp Leu Gin Ala Thr Thr Leu 35 40 45

Gly Phe Val Gly Ser Val Val Leu Ser Arg Gly Pro Tyr Ala Asp Ala 50 55 60

Met Ser Gly Ala Phe Val Ile Gly Ser Thr Gly Leu Gly Phe Leu Arg

65 70 75 80

Ala Pro Pro Ala Phe Ala Arg Pro Pro Thr Arg Val Cys Ala Trp Leu 85 90 95

Arg Leu Val Gly Gly Gly Ala Ala Val Trp Ser Leu Gly Glu Ala Gly 100 105 110

Ala Pro Pro Gly Val Pro Gly Pro Ala Thr Gin Cys Leu Ala Leu Gly

115 120 125

Ala Ala Tyr Ala Ala Leu Leu Val Leu Ala Asp Asp Val His Pro Leu 130 135 140

Phe Leu Leu Ala Pro Arg Pro Leu Phe Val Gly Thr Leu Gly Val Val

145 150 155 160

Val Gly Gly Leu Thr Ile Gly Gly Ser Ala Arg Tyr Trp Trp Ile Asp

165 170 175

Pro Arg Ala Ala Ala Ala Leu Thr Ala Ala Val Val Ala Gly Leu Gly 180 185 190

Thr Thr Ala Ala Gly Asp Ser Phe Ser Lys Ala Cys Pro Arg His Arg

195 200 205 Arg Phe Cys Val Val Ser Ala Val Glu Ser Pro Pro Pro Arg Tyr Ala

210 215 220

Pro Glu Asp Ala Glu Arg Pro. Thr Asp His Gly Pro Leu Leu Pro Ser 225 230 235 240 Thr His His Gin Arg Ser Pro Arg Val Cys Gly Asp Gly Ala Ala Arg

245 250 255

Pro Glu Asn Ile Trp Val Pro Val Val Thr Phe Ala Gly Ala Leu Ala

260 265 270

Ala Cys Ala Arg Ser Asp Ala Ala Pro Ser Gly Pro Val Leu Pro Leu 275 280 285

Trp Pro Gin Val Phe Val Gly Gly His Ala Ala Ala Gly Leu Thr Glu

290 295 300

Leu Cys Gin Thr Leu Ala Pro Arg Asp Leu Thr Asp Pro Leu Leu Phe 305 310 315 320 Ala Tyr Val Gly Phe Gin Val Val Asn His Gly Leu Met Phe Val Val

325 330 335

Pro Asp Ile Ala Val Tyr Ala Met Leu Gly Gly Ala Val Trp Ile Ser

340 345 350

Leu Thr Gin Val Leu Gly Leu Arg Arg Arg Leu His Lys Asp Pro Asp 355 360 365

Ala Gly Pro Trp Ala Ala Ala Thr Leu Arg Gly Leu Phe Phe Ser Val

370 375 380

Tyr Ala Leu Gly Phe Ala Ala Gly Val Leu Val Arg Pro Arg Met Ala 385 390 395 400 Ala Ser Arg Arg Ser Gly

405

(2) INFORMATION FOR SEQ ID NO: 281:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 644 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 281:

Met Gly Thr Glu Asp Cys Asp His Glu Gly Arg Ser Val Ala Ala Pro 1 5 10 15

Val Glu Val Met Ala Leu Tyr Ala Thr Asp Gly Cys Val Ile Thr Ser 20 25 30 Ser Leu Ala Leu Leu Thr Asn Cys Leu Leu Gly Ala Glu Pro Leu Tyr

35 40 45 Ile Phe Ser Tyr Asp Ala Tyr Arg Pro Asp Ala Pro Asn Gly Pro Thr 50 55 60 Gly Ala Pro Thr Glu Gin Glu Arg Phe Glu Gly Ser Arg Ala Leu Tyr 65 70 75 80

Arg Asp Ala Gly Gin Gly Asp Ser Phe Arg Val Thr Phe Cys Leu Leu

85 90 95 Gly Thr Glu Val Gly Val Thr His His Pro Lys Gly Arg Trp Met Phe

Val Cys Arg Phe Glu Arg Ala Asp Asp Val Ala Val Leu Gin Asp Ala

115 120 125

Leu Gly Arg Gly Thr Pro Leu Leu Pro Ala His Ile Thr Ala Thr Leu

130 135 140 Asp Leu Glu Ala Thr Phe Ala Leu His Ala Asn Ile Ile Met Ala Leu

145 150 155 160

Thr Val Ala Ile Val His Asn Ala Pro Ala Arg Ile Gly Ser Gly Ser

165 170 175 Thr Ala Pro Leu Tyr Glu Pro Gly Glu Ser Met Arg Ser Val Val Gly 180 185 190

Arg Met Ser Leu Gly Gin Arg Gly Leu Thr Thr Leu Phe Val His His

195 200 205

Glu Ala Arg Val Leu Ala Ala Tyr Arg Arg Ala Tyr Tyr Gly Ser Ala

210 215 220 Gin Ser Pro Phe Trp Phe Leu Ser Lys Phe Gly Pro Asp Glu Lys Ser

225 230 235 240

Leu Val Leu Ala Ala Arg Tyr Tyr Val Leu Gin Ala Pro Arg Leu Gly

245 250 255 Gly Ala Gly Ala Thr Tyr Asp Leu Gin Ala Val Lys Asp Ile Cys Ala 260 265 270

Thr Tyr Ala Ile Pro His Asp Pro Arg Pro Asp Thr Leu Ser Ala Ala

275 280 285

Ser Leu Thr Ser Phe Ala Ala Ile Thr Arg Phe Cys Cys Thr Ser Gin

290 295 300 Tyr Ser Arg Gly Ala Ala Ala Ala Gly Phe Pro Leu Tyr Val Glu Arg

305 310 315 320

Arg Ile Ala Ala Asp Val Arg Glu Thr Gly Ala Leu Glu Lys Phe Ile

325 330 335 Ala His Asp Arg Ser Cys Leu Arg Val Ser Asp Arg Glu Phe Ile Thr 340 345 350

Tyr Ile Tyr Leu Ala His Phe Glu Cys Phe Ser Pro Pro Arg Leu Ala

355 360 365 Thr His Leu Arg Ala Val Thr Thr His Asp Pro Ser Pro Ala Ala Ser 370 375 380

Thr Glu Gin Pro Ser Pro Leu Gly Arg Glu Ala Val Glu Gin Phe Phe 385 390 - 395 400

Arg His Val Arg Ala Gin Leu Asn Ile Arg Glu Tyr Val Lys Gin Asn 405 410 415

Val Thr Pro Arg Glu Thr Ala Gly Asp Ala Ala Ala Ala Tyr Leu Arg 420 425 430

Ala Arg Thr Tyr Ala Pro Ala Ala Leu Thr Pro Ala Pro Ala Tyr Cys 435 440 445 Gly Val Ala Asp Ser Ser Thr Lys Met Met Gly Arg Leu Ala Glu Ala 450 455 460

Glu Arg Leu Leu Val Pro His Gly Trp Pro Ala Phe Ala Pro Thr Thr 465 470 475 480

Pro Gly Asp Asp Ala Gly Gly Gly Thr Ala Ala Pro Gin Thr Cys Gly 485 490 495

Ile Val Lys Arg Leu Leu Lys Leu Ala Ala Thr Glu Gin Gin Gly Thr 500 505 510

Thr Pro Pro Ala Ile Ala Ala Leu Met Gin Asp Ala Ser Val Gin Thr 515 520 525 Pro Leu Pro Val Tyr Arg Ile Thr Met Ser Pro Thr Gly Gin Ala Phe 530 535 540

Ala Ala Ala Ala Arg Asp Asp Trp Ala Arg Val Thr Arg Asp Ala Arg 545 550 555 560

Pro Pro Glu Ala Thr Val Val Ala Asp Ala Ala Ala Ala Pro Glu Pro 565 570 575

Gly Ala Leu Gly Arg Arg Leu Thr Arg Arg Ile Cys Arg Pro Ala Pro 580 585 590

Pro Pro Gly Arg Pro Gly Arg Arg Gly Pro Asp Val Arg Glu Pro Gin 595 600 605 Arg Asp Leu Gin Arg Arg Ala Gly Arg Tyr Glu His His Pro Gly Ser 610 615 620

Gly His Arg Pro Glu Gly Ala Arg Pro Leu Ser Pro Ala Pro Arg Gly 625 630 635 640

Pro Gly Ser Leu

(2) INFORMATION FOR SEQ ID NO: 282

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 715 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ( ii ) MOLECULE TYPE : peptide

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 282 :

Met Gly Ala Gly Lys Ser Ala Leu Thr Thr Ala Arg Ala Ser Cys Ser

1 5 10 15

Arg Gly Ser Xaa Ser Glu Gly Gly Ala Ala Ala Arg Ile Ile Ser Tyr 20 25 30 Cys Cys Ser Ser Gly Arg Val Pro Gin Pro His Ser Thr Pro Ser Arg 35 40 45

Asp Ala Ile Pro Glu His Arg Ser Ala Pro Ala Phe Pro His Pro Thr

50 55 60

Pro Ser Gly Phe Ala Gly Ala Met Gly Thr Glu Asp Cys Asp His Glu 65 70 75 80

Gly Arg Ser Val Ala Ala Pro Val Glu Val Met Ala Leu Tyr Ala Thr

85 90 95

Asp Gly Cys Val Ile Thr Ser Ser Leu Ala Leu Leu Thr Asn Cys Leu 100 105 110 Leu Gly Ala Glu Pro Leu Tyr Ile Phe Ser Tyr Asp Ala Tyr Arg Pro 115 120 125

Asp Ala Pro Asn Gly Pro Thr Gly Ala Pro Thr Glu Gin Glu Arg Phe

130 135 140

Glu Gly Ser Arg Ala Leu Tyr Arg Asp Ala Gly Gin Gly Asp Ser Phe 145 150 155 160

Arg Val Thr Phe Cys Leu Leu Gly Thr Glu Val Gly Val Thr His His

165 170 175

Pro Lys Gly Arg Trp Met Phe Val Cys Arg Phe Glu Arg Ala Asp Asp 180 185 190 Val Ala Val Leu Gin Asp Ala Leu Gly Arg Gly Thr Pro Leu Leu Pro 195 200 205

Ala His Ile Thr Ala Thr Leu Asp Leu Glu Ala Thr Phe Ala Leu His

210 215 220

Ala Asn Ile Ile Met Ala Leu Thr Val Ala Ile Val His Asn Ala Pro 225 230 235 240

Ala Arg Ile Gly Ser Gly Ser Thr Ala Pro Leu Tyr Glu Pro Gly Glu

245 250 255

Ser Met Arg Ser Val Val Gly Arg Met Ser Leu Gly Gin Arg Gly Leu 260 265 270 Thr Thr Leu Phe Val His His Glu Ala Arg Val Leu Ala Ala Tyr Arg 275 280 285

Arg Ala Tyr Tyr Gly Ser Ala Gin Ser Pro Phe Trp Phe Leu Ser Lys 290 295 300 Phe Gly Pro Asp Glu Lys Ser Leu Val Leu Ala Ala Arg Tyr Tyr Val

305 310 315 320

Leu Gin Ala Pro Arg Leu Gly_. Gly Ala Gly Ala Thr Tyr Asp Leu Gin

325 330 335 Ala Val Lys Asp Ile Cys Ala Thr Tyr Ala Ile Pro His Asp Pro Arg

340 345 350

Pro Asp Thr Leu Ser Ala Ala Ser Leu Thr Ser Phe Ala Ala Ile Thr

355 360 365

Arg Phe Cys Cys Thr Ser Gin Tyr Ser Arg Gly Ala Ala Ala Ala Gly 370 375 380

Phe Pro Leu Tyr Val Glu Arg Arg Ile Ala Ala Asp Val Arg Glu Thr

385 390 395 400

Gly Ala Leu Glu Lys Phe Ile Ala His Asp Arg Ser Cys Leu Arg Val

405 410 415 Ser Asp Arg Glu Phe Ile Thr Tyr Ile Tyr Leu Ala His Phe Glu Cys

420 425 430

Phe Ser Pro Pro Arg Leu Ala Thr His Leu Arg Ala Val Thr Thr His

435 440 445

Asp Pro Ser Pro Ala Ala Ser Thr Glu Gin Pro Ser Pro Leu Gly Arg 450 455 460

Glu Ala Val Glu Gin Phe Phe Arg His Val Arg Ala Gin Leu Asn lie

465 470 475 480

Arg Glu Tyr Val Lys Gin Asn Val Thr Pro Arg Glu Thr Ala Gly Asp

485 490 495 Ala Ala Ala Ala Tyr Leu Arg Ala Arg Thr Tyr Ala Pro Ala Ala Leu

500 505 510

Thr Pro Ala Pro Ala Tyr Cys Gly Val Ala Asp Ser Ser Thr Lys Met

515 520 525

Met Gly Arg Leu Ala Glu Ala Glu Arg Leu Leu Val Pro His Gly Trp 530 535 540

Pro Ala Phe Ala Pro Thr Thr Pro Gly Asp Asp Ala Gly Gly Gly Thr

545 550 555 560

Ala Ala Pro Gin Thr Cys Gly Ile Val Lys Arg Leu Leu Lys Leu Ala

565 570 575 Ala Thr Glu Gin Gin Gly Thr Thr Pro Pro Ala Ile Ala Ala Leu Met

580 585 590

Gin Asp Ala Ser Val Gin Thr Pro Leu Pro Val Tyr Arg Ile Thr Met

595 600 605

Ser Pro Thr Gly Gin Ala Phe Ala Ala Ala Ala Arg Asp Asp Trp Ala 610 615 620

Arg Val Thr Arg Asp Ala Arg Pro Pro Glu Ala Thr Val Val Ala Asp 625 630 635 640

Ala Ala Ala Ala Pro Glu Pro Gly Ala Leu Gly Arg Arg Leu Thr Arg 645 650 655

Arg Ile Cys Arg Pro Ala Pro Pro Pro Gly Arg Pro Gly Arg Arg Gly

660 . 665 670

Pro Asp Val Arg Glu Pro Gin Arg Asp Leu Gin Arg Arg Ala Gly Arg

675 680 685

Tyr Glu His His Pro Gly Ser Gly His Arg Pro Glu Gly Ala Arg Pro

690 695 700

Leu Ser Pro Ala Pro Arg Gly Pro Gly Ser Leu 705 710 715

(2) INFORMATION FOR SEQ ID NO: 283:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 744 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 283

Met Gin Ala Trp Tyr Val Arg Ala Arg Ala Arg Ala Phe Thr Arg Arg 1 5 10 15 Arg Val Ser Ser Ser Asp Ser Arg Ala Ser Ser Ser Val Met Gly Ala 20 25 30

Gly Lys Ser Ala Leu Thr Thr Ala Arg Ala Ser Cys Ser Arg Gly Ser

35 40 45

Xaa Ser Glu Gly Gly Ala Ala Ala Arg Ile Ile Ser Tyr Cys Cys Ser 50 55 60

Ser Gly Arg Val Pro Gin Pro His Ser Thr Pro Ser Arg Asp Ala Ile 65 70 75 80

Pro Glu His Arg Ser Ala Pro Ala Phe Pro His Pro Thr Pro Ser Gly 85 90 95 Phe Ala Gly Ala Met Gly Thr Glu Asp Cys Asp His Glu Gly Arg Ser 100 105 110

Val Ala Ala Pro Val Glu Val Met Ala Leu Tyr Ala Thr Asp Gly Cys

115 120 125

Val Ile Thr Ser Ser Leu Ala Leu Leu Thr Asn Cys Leu Leu Gly Ala 130 135 140

Glu Pro Leu Tyr Ile Phe Ser Tyr Asp Ala Tyr Arg Pro Asp Ala Pro 145 150 155 160

Asn Gly Pro Thr Gly Ala Pro Thr Glu Gin Glu Arg Phe Glu Gly Ser 165 170 175

Arg Ala Leu Tyr Arg Asp Ala Gly Gin Gly Asp Ser Phe Arg Val Thr

180 - 185 190

Phe Cys Leu Leu Gly Thr Glu Val Gly Val Thr His His Pro Lys Gly 195 200 205

Arg Trp Met Phe Val Cys Arg Phe Glu Arg Ala Asp Asp Val Ala Val

210 215 220

Leu Gin Asp Ala Leu Gly Arg Gly Thr Pro Leu Leu Pro Ala His Ile 225 230 235 240 Thr Ala Thr Leu Asp Leu Glu Ala Thr Phe Ala Leu His Ala Asn Ile

245 250 255

Ile Met Ala Leu Thr Val Ala Ile Val His Asn Ala Pro Ala Arg Ile

260 265 270

Gly Ser Gly Ser Thr Ala Pro Leu Tyr Glu Pro Gly Glu Ser Met Arg 275 280 285

Ser Val Val Gly Arg Met Ser Leu Gly Gin Arg Gly Leu Thr Thr Leu

290 295 300

Phe Val His His Glu Ala Arg Val Leu Ala Ala Tyr Arg Arg Ala Tyr 305 310 315 320 Tyr Gly Ser Ala Gin Ser Pro Phe Trp Phe Leu Ser Lys Phe Gly Pro

325 330 335

Asp Glu Lys Ser Leu Val Leu Ala Ala Arg Tyr Tyr Val Leu Gin Ala

340 345 350

Pro Arg Leu Gly Gly Ala Gly Ala Thr Tyr Asp Leu Gin Ala Val Lys 355 360 365

Asp Ile Cys Ala Thr Tyr Ala Ile Pro His Asp Pro Arg Pro Asp Thr

370 375 380

Leu Ser Ala Ala Ser Leu Thr Ser Phe Ala Ala Ile Thr Arg Phe Cys 385 390 395 400 Cys Thr Ser Gin Tyr Ser Arg Gly Ala Ala Ala Ala Gly Phe Pro Leu

405 410 415

Tyr Val Glu Arg Arg Ile Ala Ala Asp Val Arg Glu Thr Gly Ala Leu

420 425 430

Glu Lys Phe Ile Ala His Asp Arg Ser Cys Leu Arg Val Ser Asp Arg 435 440 445

Glu Phe Ile Thr Tyr Ile Tyr Leu Ala His Phe Glu Cys Phe Ser Pro

450 455 460

Pro Arg Leu Ala Thr His Leu Arg Ala Val Thr Thr His Asp Pro Ser 465 470 475 480 Pro Ala Ala Ser Thr Thr Glu Gin Pro Ser Pro Leu Gly Arg Glu Ala

485 490 495

Val Glu Gin Phe Phe Arg His Arg Ala Gin Leu Asn Ile Arg Glu Tyr 500 505 510 Val Lys Gin Asn Val Thr Pro Arg Glu Thr Ala Gly Asp Ala Ala Ala

515 520 525

Ala Tyr Leu Arg Ala Arg Thr_. Tyr Ala Pro Ala Ala Leu Thr Pro Ala

530 535 540 Pro Ala Tyr Cys Gly Val Ala Asp Ser Ser Thr Lys Met Met Gly Arg

545 550 555 560

Leu Ala Glu Ala Glu Arg Leu Leu Val Pro His Gly Trp Pro Ala Phe

565 570 575

Ala Pro Thr Thr Pro Gly Asp Asp Ala Gly Gly Gly Thr Ala Ala Pro 580 585 590

Gin Thr Cys Gly Ile Val Lys Arg Leu Leu Lys Leu Ala Ala Thr Glu

595 600 605

Gin Gin Gly Thr Thr Pro Pro Ala Ile Ala Ala Leu Met Gin Asp Ala

610 615 620 Ser Val Gin Thr Pro Leu Pro Val Tyr Arg Ile Thr Met Ser Pro Thr

625 630 635 640

Gly Gin Ala Phe Ala Ala Ala Ala Arg Asp Asp Trp Ala Arg Val Thr

645 650 655

Arg Asp Ala Arg Pro Pro Glu Ala Thr Val Val Ala Asp Ala Ala Ala 660 665 670

Ala Pro Glu Pro Gly Ala Leu Gly Arg Arg Leu Thr Arg Arg Ile Cys

675 680 685

Arg Pro Ala Pro Pro Pro Gly Arg Pro Gly Arg Arg Gly Pro Asp Val

690 695 700 Arg Glu Pro Gin Arg Asp Leu Gin Arg Arg Ala Gly Arg Tyr Glu His

705 710 715 720

His Pro Gly Ser Gly His Arg Pro Glu Gly Ala Arg Pro Leu Ser Pro

725 730 735

Ala Pro Arg Gly Pro Gly Ser Leu 740

(2) INFORMATION FOR SEQ ID NO: 284:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 762 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:284: Met Val Glu Pro Ser Ser Pro Gly Trp Trp Arg Ala Ser Leu Ser Arg

1 5 10 15

Leu Thr Met Gin Ala Trp Tyr_.Val Arg Ala Arg Ala Arg Ala Phe Thr 20 25 30 Arg Arg Arg Val Ser Ser Ser Asp Ser Arg Ala Ser Ser Ser Val Met 35 40 45

Gly Ala Gly Lys Ser Ala Leu Thr Thr Ala Arg Ala Ser Cys Ser Arg

50 55 60

Gly Ser Xaa Ser Glu Gly Gly Ala Ala Ala Arg Ile Ile Ser Tyr Cys 65 70 75 80

Cys Ser Ser Gly Arg Val Pro Gin Pro His Ser Thr Pro Ser Arg Asp

85 90 95

Ala Ile Pro Glu His Arg Ser Ala Pro Ala Phe Pro His Pro Thr Pro 100 105 110 Ser Gly Phe Ala Gly Ala Met Gly Thr Glu Asp Cys Asp His Glu Gly 115 120 125

Arg Ser Val Ala Ala Pro Val Glu Val Met Ala Leu Tyr Ala Thr Asp

130 135 140

Gly Cys Val He Thr Ser Ser Leu Ala Leu Leu Thr Asn Cys Leu Leu 145 150 155 160

Gly Ala Glu Pro Leu Tyr Ile Phe Ser Tyr Asp Ala Tyr Arg Pro Asp

165 170 175

Ala Pro Asn Gly Pro Thr Gly Ala Pro Thr Glu Gin Glu Arg Phe Glu 180 185 190 Gly Ser Arg Ala Leu Tyr Arg Asp Ala Gly Gin Gly Asp Ser Phe Arg 195 200 205

Val Thr Phe Cys Leu Leu Gly Thr Glu Val Gly Val Thr His His Pro

210 215 220

Lys Gly Arg Trp Met Phe Val Cys Arg Phe Glu Arg Ala Asp Asp Val 225 230 235 240

Ala Val Leu Gin Asp Ala Leu Gly Arg Gly Thr Pro Leu Leu Pro Ala

245 250 255

His Ile Thr Ala Thr Leu Asp Leu Glu Ala Thr Phe Ala Leu His Ala 260 265 270 Asn Ile Ile Met Ala Leu Thr Val Ala Ile Val His Asn Ala Pro Ala 275 280 285

Arg Ile Gly Ser Gly Ser Thr Ala Pro Leu Tyr Glu Pro Gly Glu Ser

290 295 300

Met Arg Ser Val Val Gly Arg Met Ser Leu Gly Gin Arg Gly Leu Thr 305 310 315 320

Thr Leu Phe Val His His Glu Ala Arg Val Leu Ala Ala Tyr Arg Arg

325 330 335

Ala Tyr Tyr Gly Ser Ala Gin Ser Pro Phe Trp Phe Leu Ser Lys Phe 340 345 350

Gly Pro Asp Glu Lys Ser Leu Val Leu Ala Ala Arg Tyr Tyr Val Leu

355 360 365

Gin Ala Pro Arg Leu Gly Gly Ala Gly Ala Thr Tyr Asp Leu Gin Ala 370 375 380

Val Lys Asp Ile Cys Ala Thr Tyr Ala Ile Pro His Asp Pro Arg Pro

385 390 395 400

Asp Thr Leu Ser Ala Ala Ser Leu Thr Ser Phe Ala Ala Ile Thr Arg

405 410 415 Phe Cys Cys Thr Ser Gin Tyr Ser Arg Gly Ala Ala Ala Ala Gly Phe

420 425 430

Pro Leu Tyr Val Glu Arg Arg Ile Ala Ala Asp Val Arg Glu Thr Gly

435 440 445

Ala Leu Glu Lys Phe Ile Ala His Asp Arg Ser Cys Leu Arg Val Ser 450 455 460

Asp Arg Glu Phe Ile Thr Tyr Ile Tyr Leu Ala His Phe Glu Cys Phe

465 470 475 480

Ser Pro Pro Arg Leu Ala Thr His Leu Arg Ala Val Thr Thr His Asp

485 490 495 Pro Ser Pro Ala Ala Ser Thr Glu Gin Pro Ser Pro Leu Gly Arg Glu

500 505 510

Ala Val Glu Gin Phe Phe Arg His Val Arg Ala Gin Leu Asn Ile Arg

515 520 525

Glu Tyr Val Lys Gin Asn Val Thr Pro Arg Glu Thr Ala Gly Asp Ala 530 535 540

Ala Ala Ala Tyr Leu Arg Ala Arg Thr Tyr Ala Pro Ala Ala Leu Thr

545 550 555 560

Pro Ala Pro Ala Tyr Cys Gly Val Ala Asp Ser Ser Thr Lys Met Met

565 570 575 Gly Arg Leu Ala Glu Ala Glu Arg Leu Leu Val Pro His Gly Trp Pro

580 585 590

Ala Phe Ala Pro Thr Thr Pro Gly Asp Asp Ala Gly Gly Gly Thr Ala

595 600 605

Ala Pro Gin Thr Cys Gly Ile Val Lys Arg Leu Leu Lys Leu Ala Ala 610 615 620

Thr Glu Gin Gin Gly Thr Thr Pro Pro Ala Ile Ala Ala Leu Met Gin 625 630 635 640

Asp Ala Ser Val Gin Thr Pro Leu Pro Val Tyr Arg Ile Thr Met Ser 645 650 655 Pro Thr Gly Gin Ala Phe Ala Ala Ala Ala Arg Asp Asp Trp Ala Arg 660 665 670

Val Thr Arg Asp Ala Arg Pro Pro Glu Ala Thr Val Val Ala Asp Ala 675 680 685 Ala Ala Ala Pro Glu Pro Gly Ala Leu Gly Arg Arg Leu Thr Arg Arg

690 695 700

Ile Cys Arg Pro Ala Pro Pro. Pro Gly Arg Pro Gly Arg Arg Gly Pro 705 710 715 720 Asp Val Arg Glu Pro Gin Arg Asp Leu Gin Arg Arg Ala Gly Arg Tyr

725 730 735

Glu His His Pro Gly Ser Gly His Arg Pro Glu Gly Ala Arg Pro Leu

740 745 750

Ser Pro Ala Pro Arg Gly Pro Gly Ser Leu 755 760

(2) INFORMATION FOR SEQ ID NO: 285:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 781 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 285:

Met His Val Ser Ala Arg Arg Arg Ile Leu Ser Arg Cys Ala Ala Thr 1 5 10 15

Ala Pro Ser Met Val Glu Pro Ser Ser Pro Gly Trp Trp Arg Ala Ser

20 25 30

Leu Ser Arg Leu Thr Met Gin Ala Trp Tyr Val Arg Ala Arg Ala Arg 35 40 45 Ala Phe Thr Arg Arg Arg Val Ser Ser Ser Asp Ser Arg Ala Ser Ser 50 55 60

Ser Val Met Gly Ala Gly Lys Ser Ala Leu Thr Thr Ala Arg Ala Ser 65 70 75 80

Cys Ser Arg Gly Ser Xaa Ser Glu Gly Gly Ala Ala Ala Arg Ile Ile 85 90 95

Ser Tyr Cys Cys Ser Ser Gly Arg Val Pro Gin Pro His Ser Thr Pro

100 105 110

Ser Arg Asp Ala Ile Pro Glu His Arg Ser Ala Pro Ala Phe Pro His 115 120 125 Pro Thr Pro Ser Gly Phe Ala Gly Ala Met Gly Thr Glu Asp Cys Asp 130 135 140

His Glu Gly Arg Ser Val Ala Ala Pro Val Glu Val Met Ala Leu Tyr 145 150 155 160 Ala Thr Asp Gly Cys Val Ile Thr Ser Ser Leu Ala Leu Leu Thr Asn

165 170 175

Cys Leu Leu Gly Ala Glu Pro Leu Tyr Ile Phe Ser Tyr Asp Ala Tyr 180 185 190 Arg Pro Asp Ala Pro Asn Gly Pro Thr Gly Ala Pro Thr Glu Gin Glu 195 200 205

Arg Phe Glu Gly Ser Arg Ala Leu Tyr Arg Asp Ala Gly Gin Gly Asp

210 215 220

Ser Phe Arg Val Thr Phe Cys Leu Leu Gly Thr Glu Val Gly Val Thr 225 230 235 240

His His Pro Lys Gly Arg Trp Met Phe Val Cys Arg Phe Glu Arg Ala

245 250 255

Asp Asp Val Ala Val Leu Gin Asp Ala Leu Gly Arg Gly Thr Pro Leu 260 265 270 Leu Pro Ala His Ile Thr Ala Thr Leu Asp Leu Glu Ala Thr Phe Ala 275 280 285

Leu His Ala Asn Ile Ile Met Ala Leu Thr Val Ala Ile Val His Asn

290 295 300

Ala Pro Ala Arg Ile Gly Ser Gly Ser Thr Ala Pro Leu Tyr Glu Pro 305 310 315 320

Gly Glu Ser Met Arg Ser Val Val Gly Arg Met Ser Leu Gly Gin Arg

325 330 335

Gly Leu Thr Thr Leu Phe Val His His Glu Ala Arg Val Leu Ala Ala 340 345 350 Tyr Arg Arg Ala Tyr Tyr Gly Ser Ala Gin Ser Pro Phe Trp Phe Leu 355 360 365

Ser Lys Phe Gly Pro Asp Glu Lys Ser Leu Val Leu Ala Ala Arg Tyr

370 375 380

Tyr Val Leu Gin Ala Pro Arg Leu Gly Gly Ala Gly Ala Thr Tyr Asp 385 390 395 400

Leu Gin Ala Val Lys Asp Ile Cys Ala Thr Tyr Ala Ile Pro His Asp

405 410 415

Pro Arg Pro Asp Thr Leu Ser Ala Ala Ser Leu Thr Ser Phe Ala Ala 420 425 430 Ile Thr Arg Phe Cys Cys Thr Ser Gin Tyr Ser Arg Gly Ala Ala Ala 435 440 445

Ala Gly Phe Pro Leu Tyr Val Glu Arg Arg Ile Ala Ala Asp Val Arg

450 455 460

Glu Thr Gly Ala Leu Glu Lys Phe Ile Ala His Asp Arg Ser Cys Leu 465 470 475 480

Arg Val Ser Asp Arg Glu Phe Ile Thr Tyr Ile Tyr Leu Ala His Phe

485 490 495

Glu Cys Phe Ser Pro Pro Arg Leu Ala Thr His Leu Arg Ala Val Thr 500 505 510

Thr His Asp Pro Ser Pro Ala Ala Ser Thr Glu Gin Pro Ser Pro Leu

515 520 525

Gly Arg Glu Ala Val Glu Gin Phe Phe Arg His Val Arg Ala Gin Leu 530 535 540

Asn Ile Arg Glu Tyr Val Lys Gin Asn Val Thr Pro Arg Glu Thr Ala

545 550 555 560

Gly Asp Ala Ala Ala Ala Tyr Leu Arg Ala Arg Thr Tyr Ala Pro Ala

565 570 575 Ala Leu Thr Pro Ala Pro Ala Tyr Cys Gly Val Ala Asp Ser Ser Thr

580 585 590

Lys Met Met Gly Arg Leu Ala Glu Ala Glu Arg Leu Leu Val Pro His

595 600 605

Gly Trp Pro Ala Phe Ala Pro Thr Thr Pro Gly Asp Asp Ala Gly Gly 610 615 620

Gly Thr Ala Ala Pro Gin Thr Cys Gly lie Val Lys Arg Leu Leu Lys

625 630 635 640

Leu Ala Ala Thr Glu Gin Gin Gly Thr Thr Pro Pro Ala Ile Ala Ala

645 650 655 Leu Met Gin Asp Ala Ser Val Gin Thr Pro Leu Pro Val Tyr Arg Ile

660 665 670

Thr Met Ser Pro Thr Gly Gin Ala Phe Ala Ala Ala Ala Arg Asp Asp

675 680 685

Trp Ala Arg Val Thr Arg Asp Ala Arg Pro Pro Glu Ala Thr Val Val 690 695 700

Ala Asp Ala Ala Ala Ala Pro Glu Pro Gly Ala Leu Gly Arg Arg Leu

705 710 715 720

Thr Arg Arg Ile Cys Arg Pro Ala Pro Pro Pro Gly Arg Pro Gly Arg

725 730 735 Arg Gly Pro Asp Val Arg Glu Pro Gin Arg Asp Leu Gin Arg Arg Ala

740 745 750

Gly Arg Tyr Glu His His Pro Gly Ser Gly His Arg Pro Glu Gly Ala

755 760 765

Arg Pro Leu Ser Pro Ala Pro Arg Gly Pro Gly Ser Leu 770 775 780

(2) INFORMATION FOR SEQ ID NO: 286:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 784 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ( ii ) MOLECULE TYPE : peptide

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 286 :

Met Val Ala Met His Val Ser Ala Arg Arg Arg Ile Leu Ser Arg Cys

1 5 10 15

Ala Ala Thr Ala Pro Ser Met Val Glu Pro Ser Ser Pro Gly Trp Trp 20 25 30 Arg Ala Ser Leu Ser Arg Leu Thr Met Gin Ala Trp Tyr Val Arg Ala 35 40 45

Arg Ala Arg Ala Phe Thr Arg Arg Arg Val Ser Ser Ser Asp Ser Arg

50 55 60

Ala Ser Ser Ser Val Met Gly Ala Gly Lys Ser Ala Leu Thr Thr Ala 65 70 75 80

Arg Ala Ser Cys Ser Arg Gly Ser Xaa Ser Glu Gly Gly Ala Ala Ala

85 90 95

Arg Ile Ile Ser Tyr Cys Cys Ser Ser Gly Arg Val Pro Gin Pro His 100 105 110 Ser Thr Pro Ser Arg Asp Ala Ile Pro Glu His Arg Ser Ala Pro Ala 115 120 125

Phe Pro His Pro Thr Pro Ser Gly Phe Ala Gly Ala Met Gly Thr Glu

130 135 140

Asp Cys Asp His Glu Gly Arg Ser Val Ala Ala Pro Val Glu Val Met 145 150 155 160

Ala Leu Tyr Ala Thr Asp Gly Cys Val Ile Thr Ser Ser Leu Ala Leu

165 170 175

Leu Thr Asn Cys Leu Leu Gly Ala Glu Pro Leu Tyr Ile Phe Ser Tyr 180 185 190 Asp Ala Tyr Arg Pro Asp Ala Pro Asn Gly Pro Thr Gly Ala Pro Thr 195 200 205

Glu Gin Glu Arg Phe Glu Gly Ser Arg Ala Leu Tyr Arg Asp Ala Gly

210 215 220

Gin Gly Asp Ser Phe Arg Val Thr Phe Cys Leu Leu Gly Thr Glu Val 225 230 235 240

Gly Val Thr His His Pro Lys Gly Arg Trp Met Phe Val Cys Arg Phe

245 250 255

Glu Arg Ala Asp Asp Val Ala Val Leu Gin Asp Ala Leu Gly Arg Gly 260 265 270 Thr Pro Leu Leu Pro Ala His Ile Thr Ala Thr Leu Asp Leu Glu Ala 275 280 285

Thr Phe Ala Leu His Ala Asn Ile Ile Met Ala Leu Thr Val Ala Ile 290 295 300 Val His Asn Ala Pro Ala Arg Ile Gly Ser Gly Ser Thr Ala Pro Leu

305 310 315 320

Tyr Glu Pro Gly Glu Ser Met _.Arg Ser Val Val Gly Arg Met Ser Leu

325 330 335 Gly Gin Arg Gly Leu Thr Thr Leu Phe Val His His Glu Ala Arg Val

340 345 350

Leu Ala Ala Tyr Arg Arg Ala Tyr Tyr Gly Ser Ala Gin Ser Pro Phe

355 360 365

Trp Phe Leu Ser Lys Phe Gly Pro Asp Glu Lys Ser Leu Val Leu Ala 370 375 380

Ala Arg Tyr Tyr Val Leu Gin Ala Pro Arg Leu Gly Gly Ala Gly Ala

385 390 395 400

Thr Tyr Asp Leu Gin Ala Val Lys Asp Ile Cys Ala Thr Tyr Ala Ile

405 410 415 Pro His Asp Pro Arg Pro Asp Thr Leu Ser Ala Ala Ser Leu Thr Ser

420 425 430

Phe Ala Ala Ile Thr Arg Phe Cys Cys Thr Ser Gin Tyr Ser Arg Gly

435 440 445

Ala Ala Ala Ala Gly Phe Pro Leu Tyr Val Glu Arg Arg Ile Ala Ala 450 455 460

Asp Val Arg Glu Thr Gly Ala Leu Glu Lys Phe Ile Ala His Asp Arg

465 470 475 480

Ser Cys Leu Arg Val Ser Asp Arg Glu Phe Ile Thr Tyr Ile Tyr Leu

485 490 495 Ala His Phe Glu Cys Phe Ser Pro Pro Arg Leu Ala Thr His Leu Arg

500 505 510

Ala Val Thr Thr His Asp Pro Ser Pro Ala Ala Ser Thr Glu Gin Pro

515 520 525

Ser Pro Leu Gly Arg Glu Ala Val Glu Gin Phe Phe Arg His Val Arg 530 535 540

Ala Gin Leu Asn Ile Arg Glu Tyr Val Lys Gin Asn Val Thr Pro Arg

545 550 555 560

Glu Thr Ala Gly Asp Ala Ala Ala Ala Tyr Leu Arg Ala Arg Thr Tyr

565 570 575 Ala Pro Ala Ala Leu Thr Pro Ala Pro Ala Tyr Cys Gly Val Ala Asp

580 585 590

Ser Ser Thr Lys Met Met Gly Arg Leu Ala Glu Ala Glu Arg Leu Leu

595 600 605

Val Pro His Gly Trp Pro Ala Phe Ala Pro Thr Thr Pro Gly Asp Asp 610 615 620

Ala Gly Gly Gly Thr Ala Ala Pro Gin Thr Cys Gly Ile Val Lys Arg 625 630 635 640

Leu Leu Lys Leu Ala Ala Thr Glu Gin Gin Gly Thr Thr Pro Pro Ala 645 650 655

He Ala Ala Leu Met Gin Asp Ala Ser Val Gin Thr Pro Leu Pro Val 660 665 670

Tyr Arg He Thr Met Ser Pro Thr Gly Gin Ala Phe Ala Ala Ala Ala 675 680 685

Arg Asp Asp Trp Ala Arg Val Thr Arg Asp Ala Arg Pro Pro Glu Ala 690 695 700

Thr Val Val Ala Asp Ala Ala Ala Ala Pro Glu Pro Gly Ala Leu Gly

705 710 715 720

Arg Arg Leu Thr Arg Arg He Cys Arg Pro Ala Pro Pro Pro Gly Arg 725 730 735

Pro Gly Arg Arg Gly Pro Asp Val Arg Glu Pro Gin Arg Asp Leu Gin 740 745 750

Arg Arg Ala Gly Arg Tyr Glu His His Pro Gly Ser Gly His Arg Pro

755 760 765

Glu Gly Ala Arg Pro Leu Ser Pro Ala Pro Arg Gly Pro Gly Ser Leu 770 775 780

(2) INFORMATION FOR SEQ ID NO: 287:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 789 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:287:

Met Tyr Ile Cys Arg Met Val Ala Met His Val Ser Ala Arg Arg Arg

1 5 10 15

Ile Leu Ser Arg Cys Ala Ala Thr Ala Pro Ser Met Val Glu Pro Ser 20 25 30 Ser Pro Gly Trp Trp Arg Ala Ser Leu Ser Arg Leu Thr Met Gin Ala 35 40 45

Trp Tyr Val Arg Ala Arg Ala Arg Ala Phe Thr Arg Arg Arg Val Ser

50 55 60

Ser Ser Asp Ser Arg Ala Ser Ser Ser Val Met Gly Ala Gly Lys Ser 65 70 75 80

Ala Leu Thr Thr Ala Arg Ala Ser Cys Ser Arg Gly Ser Xaa Ser Glu

85 90 95

Gly Gly Ala Ala Ala Arg Ile Ile Ser Tyr Cys Cys Ser Ser Gly Arg 100 105 110

Val Pro Gin Pro His Ser Thr Pro Ser Arg Asp Ala Ile Pro Glu His

115 _.120 125

Arg Ser Ala Pro Ala Phe Pro His Pro Thr Pro Ser Gly Phe Ala Gly 130 135 140

Ala Met Gly Thr Glu Asp Cys Asp His Glu Gly Arg Ser Val Ala Ala

145 150 155 160

Pro Val Glu Val Met Ala Leu Tyr Ala Thr Asp Gly Cys Val Ile Thr

165 170 175 Ser Ser Leu Ala Leu Leu Thr Asn Cys Leu Leu Gly Ala Glu Pro Leu

180 185 190

Tyr Ile Phe Ser Tyr Asp Ala Tyr Arg Pro Asp Ala Pro Asn Gly Pro

195 200 205

Thr Gly Ala Pro Thr Glu Gin Glu Arg Phe Glu Gly Ser Arg Ala Leu 210 215 220

Tyr Arg Asp Ala Gly Gin Gly Asp Ser Phe Arg Val Thr Phe Cys Leu

225 230 235 240

Leu Gly Thr Glu Val Gly Val Thr His His Pro Lys Gly Arg Trp Met

245 250 255 Phe Val Cys Arg Phe Glu Arg Ala Asp Asp Val Ala Val Leu Gin Asp

260 265 270

Ala Leu Gly Arg Gly Thr Pro Leu Leu Pro Ala His Ile Thr Ala Thr

275 280 285

Leu Asp Leu Glu Ala Thr Phe Ala Leu His Ala Asn Ile He Met Ala 290 295 300

Leu Thr Val Ala Ile Val His Asn Ala Pro Ala Arg Ile Gly Ser Gly

305 310 315 320

Ser Thr Ala Pro Leu Tyr Glu Pro Gly Glu Ser Met Arg Ser Val Val

325 330 335 Gly Arg Met Ser Leu Gly Gin Arg Gly Leu Thr Thr Leu Phe Val His

340 345 350

His Glu Ala Arg Val Leu Ala Ala Tyr Arg Arg Ala Tyr Tyr Gly Ser

355 360 365

Ala Gin Ser Pro Phe Trp Phe Leu Ser Lys Phe Gly Pro Asp Glu Lys 370 375 380

Ser Leu Val Leu Ala Ala Arg Tyr Tyr Val Leu Gin Ala Pro Arg Leu 385 390 395 400

Gly Gly Ala Gly Ala Thr Tyr Asp Leu Gin Ala Val Lys Asp Ile Cys 405 410 415 Ala Thr Tyr Ala Ile Pro His Asp Pro Arg Pro Asp Thr Leu Ser Ala 420 425 430

Ala Ser Leu Thr Ser Phe Ala Ala Ile Thr Arg Phe Cys Cys Thr Ser 435 440 445 Gin Tyr Ser Arg Gly Ala Ala Ala Ala Gly Phe Pro Leu Tyr Val Glu

450 455 460

Arg Arg Ile Ala Ala Asp Val_. Arg Glu Thr Gly Ala Leu Glu Lys Phe 465 470 475 480 Ile Ala His Asp Arg Ser Cys Leu Arg Val Ser Asp Arg Glu Phe lie

485 490 495

Thr Tyr Ile Tyr Leu Ala His Phe Glu Cys Phe Ser Pro Pro Arg Leu

500 505 510

Ala Thr His Leu Arg Ala Val Thr Thr His Asp Pro Ser Pro Ala Ala 515 520 525

Ser Thr Glu Gin Pro Ser Pro Leu Gly Arg Glu Ala Val Glu Gin Phe

530 535 540

Phe Arg His Val Arg Ala Gin Leu Asn Ile Arg Glu Tyr Val Lys Gin 545 550 555 560 Asn Val Thr Pro Arg Glu Thr Ala Gly Asp Ala Ala Ala Ala Tyr Leu

565 570 575

Arg Ala Arg Thr Tyr Ala Pro Ala Ala Leu Thr Pro Ala Pro Ala Tyr

580 585 590

Cys Gly Val Ala Asp Ser Ser Thr Lys Met Met Gly Arg Leu Ala Glu 595 600 605

Ala Glu Arg Leu Leu Val Pro His Gly Trp Pro Ala Phe Ala Pro Thr

610 615 620

Thr Pro Gly Asp Asp Ala Gly Gly Gly Thr Ala Ala Pro Gin Thr Cys 625 630 635 640 Gly Ile Val Lys Arg Leu Leu Lys Leu Ala Ala Thr Glu Gin Gin Gly

645 650 655

Thr Thr Pro Pro Ala Ile Ala Ala Leu Met Gin Asp Ala Ser Val Gin

660 665 670

Thr Pro Leu Pro Val Tyr Arg Ile Thr Met Ser Pro Thr Gly Gin Ala 675 680 685

Phe Ala Ala Ala Ala Arg Asp Asp Trp Ala Arg Val Thr Arg Asp Ala

690 695 700

Arg Pro Pro Glu Ala Thr Val Val Ala Asp Ala Ala Ala Ala Pro Glu 705 710 715 720 Pro Gly Ala Leu Gly Arg Arg Leu Thr Arg Arg Ile Cys Arg Pro Ala

725 730 735

Pro Pro Pro Gly Arg Pro Gly Arg Arg Gly Pro Asp Val Arg Glu Pro

740 745 750

Gin Arg Asp Leu Gin Arg Arg Ala Gly Arg Tyr Glu His His Pro Gly 755 760 765

Ser Gly His Arg Pro Glu Gly Ala Arg Pro Leu Ser Pro Ala Pro Arg

770 775 780

Gly Pro Gly Ser Leu 785

(2) INFORMATION FOR SEQ ID NO: 288:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 809 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 288:

Met Leu Arg Met Ala Trp Glu Thr Ser Thr Ser Ala Asp Leu Ser Ala 1 5 10 15

Ala Pro Thr Asp Met Tyr Ile Cys Arg Met Val Ala Met His Val Ser

20 25 30

Ala Arg Arg Arg Ile Leu Ser Arg Cys Ala Ala Thr Ala Pro Ser Met 35 40 45

Val Glu Pro Ser Ser Pro Gly Trp Trp Arg Ala Ser Leu Ser Arg Leu

50 55 60

Thr Met Gin Ala Trp Tyr Val Arg Ala Arg Ala Arg Ala Phe Thr Arg 65 70 75 80 Arg Arg Val Ser Ser Ser Asp Ser Arg Ala Ser Ser Ser Val Met Gly

85 90 95

Ala Gly Lys Ser Ala Leu Thr Thr Ala Arg Ala Ser Cys Ser Arg Gly

100 105 110

Ser Xaa Ser Glu Gly Gly Ala Ala Ala Arg Ile Ile Ser Tyr Cys Cys 115 120 125

Ser Ser Gly Arg Val Pro Gin Pro His Ser Thr Pro Ser Arg Asp Ala

130 135 140

Ile Pro Glu His Arg Ser Ala Pro Ala Phe Pro His Pro Thr Pro Ser 145 150 155 160 Gly Phe Ala Gly Ala Met Gly Thr Glu Asp Cys Asp His Glu Gly Arg

165 170 175

Ser Val Ala Ala Pro Val Glu Val Met Ala Leu Tyr Ala Thr Asp Gly

180 185 190

Cys Val Ile Thr Ser Ser Leu Ala Leu Leu Thr Asn Cys Leu Leu Gly 195 200 205

Ala Glu Pro Leu Tyr Ile Phe Ser Tyr Asp Ala Tyr Arg Pro Asp Ala

210 215 220

Pro Asn Gly Pro Thr Gly Ala Pro Thr Glu Gin Glu Arg Phe Glu Gly 225 230 235 240

Ser Arg Ala Leu Tyr Arg Asp Ala Gly Gin Gly Asp Ser Phe Arg Val

245 _. 250 255

Thr Phe Cys Leu Leu Gly Thr Glu Val Gly Val Thr His His Pro Lys 260 265 270

Gly Arg Trp Met Phe Val Cys Arg Phe Glu Arg Ala Asp Asp Val Ala

275 280 285

Val Leu Gin Asp Ala Leu Gly Arg Gly Thr Pro Leu Leu Pro Ala His

290 295 300 Ile Thr Ala Thr Leu Asp Leu Glu Ala Thr Phe Ala Leu His Ala Asn

305 310 315 320

Ile Ile Met Ala Leu Thr Val Ala Ile Val His Asn Ala Pro Ala Arg

325 330 335

Ile Gly Ser Gly Ser Thr Ala Pro Leu Tyr Glu Pro Gly Glu Ser Met 340 345 350

Arg Ser Val Val Gly Arg Met Ser Leu Gly Gin Arg Gly Leu Thr Thr

355 360 365

Leu Phe Val His His Glu Ala Arg Val Leu Ala Ala Tyr Arg Arg Ala

370 375 380 Tyr Tyr Gly Ser Ala Gin Ser Pro Phe Trp Phe Leu Ser Lys Phe Gly

385 390 395 400

Pro Asp Glu Lys Ser Leu Val Leu Ala Ala Arg Tyr Tyr Val Leu Gin

405 410 415

Ala Pro Arg Leu Gly Gly Ala Gly Ala Thr Tyr Asp Leu Gin Ala Val 420 425 430

Lys Asp Ile Cys Ala Thr Tyr Ala Ile Pro His Asp Pro Arg Pro Asp

435 440 445

Thr Leu Ser Ala Ala Ser Leu Thr Ser Phe Ala Ala Ile Thr Arg Phe

450 455 460 Cys Cys Thr Ser Gin Tyr Ser Arg Gly Ala Ala Ala Ala Gly Phe Pro

465 470 475 480

Leu Tyr Val Glu Arg Arg Ile Ala Ala Asp Val Arg Glu Thr Gly Ala

485 490 495

Leu Glu Lys Phe Ile Ala His Asp Arg Ser Cys Leu Arg Val Ser Asp 500 505 510

Arg Glu Phe Ile Thr Tyr Ile Tyr Leu Ala His Phe Glu Cys Phe Ser

515 520 525

Pro Pro Arg Leu Ala Thr His Leu Arg Ala Val Thr Thr His Asp Pro 530 535 540 Ser Pro Ala Ala Ser Thr Glu Gin Pro Ser Pro Leu Gly Arg Glu Ala 545 550 555 560

Val Glu Gin Phe Phe Arg His Val Arg Ala Gin Leu Asn Ile Arg Glu 565 570 575 Tyr Val Lys Gin Asn Val Thr Pro Arg Glu Thr Ala Gly Asp Ala Ala

580 585 590

Ala Ala Tyr Leu Arg Ala Arg. Thr Tyr Ala Pro Ala Ala Leu Thr Pro 595 600 605 Ala Pro Ala Tyr Cys Gly Val Ala Asp Ser Ser Thr Lys Met Met Gly 610 615 620

Arg Leu Ala Glu Ala Glu Arg Leu Leu Val Pro His Gly Trp Pro Ala 625 630 635 640

Phe Ala Pro Thr Thr Pro Gly Asp Asp Ala Gly Gly Gly Thr Ala Ala 645 650 655

Pro Gin Thr Cys Gly Ile Val Lys Arg Leu Leu Lys Leu Ala Ala Thr

660 665 670

Glu Gin Gin Gly Thr Thr Pro Pro Ala Ile Ala Ala Leu Met Gin Asp 675 680 685 Ala Ser Val Gin Thr Pro Leu Pro Val Tyr Arg Ile Thr Met Ser Pro 690 695 700

Thr Gly Gin Ala Phe Ala Ala Ala Ala Arg Asp Asp Trp Ala Arg Val 705 710 715 720

Thr Arg Asp Ala Arg Pro Pro Glu Ala Thr Val Val Ala Asp Ala Ala 725 730 735

Ala Ala Pro Glu Pro Gly Ala Leu Gly Arg Arg Leu Thr Arg Arg lie

740 745 750

Cys Arg Pro Ala Pro Pro Pro Gly Arg Pro Gly Arg Arg Gly Pro Asp 755 760 765 Val Arg Glu Pro Gin Arg Asp Leu Gin Arg Arg Ala Gly Arg Tyr Glu 770 775 780

His His Pro Gly Ser Gly His Arg Pro Glu Gly Ala Arg Pro Leu Ser 785 790 795 800

Pro Ala Pro Arg Gly Pro Gly Ser Leu 805

(2) INFORMATION FOR SEQ ID NO: 289:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 816 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 289: Met Thr Thr Ser Leu Ser Ala Met Leu Arg Met Ala Trp Glu Thr Ser

1 5 10 15

Thr Ser Ala Asp Leu Ser Ala_. Ala Pro Thr Asp Met Tyr Ile Cys Arg 20 25 30

Met Val Ala Met His Val Ser Ala Arg Arg Arg Ile Leu Ser Arg Cys 35 40 45

Ala Ala Thr Ala Pro Ser Met Val Glu Pro Ser Ser Pro Gly Trp Trp 50 55 60

Arg Ala Ser Leu Ser Arg Leu Thr Met Gin Ala Trp Tyr Val Arg Ala

65 70 75 80

Arg Ala Arg Ala Phe Thr Arg Arg Arg Val Ser Ser Ser Asp Ser Arg 85 90 95

Ala Ser Ser Ser Val Met Gly Ala Gly Lys Ser Ala Leu Thr Thr Ala 100 105 110

Arg Ala Ser Cys Ser Arg Gly Ser Xaa Ser Glu Gly Gly Ala Ala Ala

115 120 125

Arg Ile Ile Ser Tyr Cys Cys Ser Ser Gly Arg Val Pro Gin Pro His

130 135 140

Ser Thr Pro Ser Arg Asp Ala Ile Pro Glu His Arg Ser Ala Pro Ala

145 150 155 160

Phe Pro His Pro Thr Pro Ser Gly Phe Ala Gly Ala Met Gly Thr Glu 165 170 175

Asp Cys Asp His Glu Gly Arg Ser Val Ala Ala Pro Val Glu Val Met 180 185 190

Ala Leu Tyr Ala Thr Asp Gly Cys Val Ile Thr Ser Ser Leu Ala Leu 195 200 205

Leu Thr Asn Cys Leu Leu Gly Ala Glu Pro Leu Tyr Ile Phe Ser Tyr 210 215 220

Asp Ala Tyr Arg Pro Asp Ala Pro Asn Gly Pro Thr Gly Ala Pro Thr

225 230 235 240

Glu Gin Glu Arg Phe Glu Gly Ser Arg Ala Leu Tyr Arg Asp Ala Gly 245 250 255

Gin Gly Asp Ser Phe Arg Val Thr Phe Cys Leu Leu Gly Thr Glu Val

260 265 270

Gly Val Thr His His Pro Lys Gly Arg Trp Met Phe Val Cys Arg Phe

275 280 285

Glu Arg Ala Asp Asp Val Ala Val Leu Gin Asp Ala Leu Gly Arg Gly 290 295 300

Thr Pro Leu Leu Pro Ala His Ile Thr Ala Thr Leu Asp Leu Glu Ala

305 310 315 320

Thr Phe Ala Leu His Ala Asn Ile Ile Met Ala Leu Thr Val Ala Ile 325 330 335

Val His Asn Ala Pro Ala Arg Ile Gly Ser Gly Ser Thr Ala Pro Leu 340 345 350

Tyr Glu Pro Gly Glu Ser Met Arg Ser Val Val Gly Arg Met Ser Leu

355 .360 365

Gly Gin Arg Gly Leu Thr Thr Leu Phe Val His His Glu Ala Arg Val 370 375 380

Leu Ala Ala Tyr Arg Arg Ala Tyr Tyr Gly Ser Ala Gin Ser Pro Phe

385 390 395 400

Trp Phe Leu Ser Lys Phe Gly Pro Asp Glu Lys Ser Leu Val Leu Ala

405 410 415 Ala Arg Tyr Tyr Val Leu Gin Ala Pro Arg Leu Gly Gly Ala Gly Ala

420 425 430

Thr Tyr Asp Leu Gin Ala Val Lys Asp Ile Cys Ala Thr Tyr Ala Ile

435 440 445

Pro His Asp Pro Arg Pro Asp Thr Leu Ser Ala Ala Ser Leu Thr Ser 450 455 460

Phe Ala Ala Ile Thr Arg Phe Cys Cys Thr Ser Gin Tyr Ser Arg Gly

465 470 475 480

Ala Ala Ala Ala Gly Phe Pro Leu Tyr Val Glu Arg Arg Ile Ala Ala

485 490 495 Asp Val Arg Glu Thr Gly Ala Leu Glu Lys Phe Ile Ala His Asp Arg

500 505 510

Ser Cys Leu Arg Val Ser Asp Arg Glu Phe Ile Thr Tyr Ile Tyr Leu

515 520 525

Ala His Phe Glu Cys Phe Ser Pro Pro Arg Leu Ala Thr His Leu Arg 530 535 540

Ala Val Thr Thr His Asp Pro Ser Pro Ala Ala Ser Thr Glu Gin Pro

545 550 555 560

Ser Pro Leu Gly Arg Glu Ala Val Glu Gin Phe Phe Arg His Val Arg

565 570 575 Ala Gin Leu Asn Ile Arg Glu Tyr Val Lys Gin Asn Val Thr Pro Arg

580 585 590

Glu Thr Ala Gly Asp Ala Ala Ala Ala Tyr Leu Arg Ala Arg Thr Tyr

595 600 605

Ala Pro Ala Ala Leu Thr Pro Ala Pro Ala Tyr Cys Gly Val Ala Ala 610 615 620

Asp Ser Ser Thr Lys Met Met Gly Arg Leu Ala Glu Ala Glu Arg Leu 625 630 635 640

Leu Val Pro Gly Trp Pro Ala Phe Ala Pro Thr Thr Pro Gly Asp Asp 645 650 655 Ala Gly Gly Gly Thr Ala Ala Pro Gin Thr Cys Gly He Val Lys Arg 660 665 670

Leu Leu Lys Leu Ala Ala Thr Glu Gin Gin Gly Thr Thr Pro Pro Ala 675 680 685 Ile Ala Ala Leu Met Gin Asp Ala Ser Val Gin Thr Pro Leu Pro Val

690 695 700

Tyr Arg Ile Thr Met Ser Pro Thr Gly Gin Ala Phe Ala Ala Ala Ala 705 710 715 720 Arg Asp Asp Trp Ala Arg Val Thr Arg Asp Ala Arg Pro Pro Glu Ala

725 730 735

Thr Val Val Ala Asp Ala Ala Ala Ala Pro Glu Pro Gly Ala Leu Gly

740 745 750

Arg Arg Leu Thr Arg Arg Ile Cys Arg Pro Ala Pro Pro Pro Gly Arg 755 760 765

Pro Gly Arg Arg Gly Pro Asp Val Arg Glu Pro Gin Arg Asp Leu Gin

770 775 780

Arg Arg Ala Gly Arg Tyr Glu His His Pro Gly Ser Gly His Arg Pro 785 790 795 800 Glu Gly Ala Arg Pro Leu Ser Pro Ala Pro Arg Gly Pro Gly Ser Leu

805 810 815

(2) INFORMATION FOR SEQ ID NO: 290:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 184 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 290:

Met Thr Thr Thr Pro Leu Ser Asn Leu Phe Leu Arg Ala Pro Asp Ile 1 5 10 15

Thr His Val Ala Pro Pro Tyr Cys Leu Asn Ala Thr Trp Gin Ala Glu

20 25 30

Asn Ala Leu His Thr Thr Lys Thr Asp Pro Ala Cys Leu Ala Ala Arg 35 40 45

Ser Tyr Leu Val Arg Ala Ser Cys Ser Thr Ser Gly Pro Ile His Cys

50 55 60

Phe Phe Phe Ala Val Tyr Lys Asp Ser Gin His Ser Leu Pro Leu Val 65 70 75 80 Thr Glu Leu Arg Asn Phe Ala Asp Leu Val Asn His Pro Pro Val Leu

85 90 95

Arg Glu Leu Glu Asp Lys Arg Gly Gly Arg Leu Arg Cys Thr Gly Pro 100 105 110 Phe Ser Cys Gly Thr Ile Lys Asp Val Ser Gly Asp Ala Gly Glu Tyr

115 120 125

Thr Ile Asn Gly Ile Val Tyr. His Cys His Cys Arg Tyr Pro Phe Ser

130 135 140 Lys Thr Cys Trp Leu Gly Ala Ser Ala Ala Leu Gin His Leu Arg Ser

145 150 155 160

Ile Ser Ser Ser Gly Thr Ala Ala Arg Ala Ala Glu Gin Arg Arg His

165 170 175

Lys Ile Lys Ile Lys Ile Lys Val 180

(2) INFORMATION FOR SEQ ID NO: 291:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 212 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 291:

Met Trp Gly Pro Gly Pro Ala Arg Phe He Ala Arg Pro Gly Thr His 1 5 10 15

Gly Arg Arg Val Phe Thr Asp Pro Pro Pro Arg Asn Met Thr Thr Thr

20 25 30

Pro Leu Ser Asn Leu Phe Leu Arg Ala Pro Asp Ile Thr His Val Ala 35 40 45 Pro Pro Tyr Cys Leu Asn Ala Thr Trp Gin Ala Glu Asn Ala Leu His 50 55 60

Thr Thr Lys Thr Asp Pro Ala Cys Leu Ala Ala Arg Ser Tyr Leu Val 65 70 75 80

Arg Ala Ser Cys Ser Thr Ser Gly Pro Ile His Cys Phe Phe Phe Ala 85 90 95

Val Tyr Lys Asp Ser Gin His Ser Leu Pro Leu Val Thr Glu Leu Arg

100 105 110

Asn Phe Ala Asp Leu Val Asn His Pro Pro Val Leu Arg Glu Leu Glu 115 120 125 Asp Lys Arg Gly Gly Arg Leu Arg Cys Thr Gly Pro Phe Ser Cys Gly 130 135 140

Thr Ile Lys Asp Val Ser Gly Asp Ala Gly Glu Tyr Thr He Asn Gly 145 150 155 160 Ile Val Tyr His Cys His Cys Arg Tyr Pro Phe Ser Lys Thr Cys Trp

165 170 175

Leu Gly Ala Ser Ala Ala Leu. Gin His Leu Arg Ser Ile Ser Ser Ser 180 185 190 Gly Thr Ala Ala Arg Ala Ala Glu Gin Arg Arg His Lys Ile Lys Ile 195 200 205

Lys Ile Lys Val 210

(2) INFORMATION FOR SEQ ID NO: 292:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 670 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 292:

Met Ala Ala Gin Arg Ala Arg Ala Pro Ala Met Arg Thr Arg Gly Gly

1 5 10 15

Asp Ala Ala Leu Cys Ala Pro Glu Asp Gly Trp Val Lys Val His Pro 20 25 30

Thr Pro Gly Thr Met Leu Phe Arg Glu Ile Leu Leu Gly Gin Met Gly

35 40 45

Tyr Thr Glu Gly Gin Gly Val Tyr Asn Val Val Arg Ser Ser Glu Ala 50 55 60 Ala Thr Arg Gin Leu Gin Ala Ala Ile Phe His Ala Leu Leu Asn Ala 65 70 75 80

Thr Tyr Asp Leu Glu Glu Asp Trp Arg Arg His Val Val Arg Leu Gin

85 90 95

Pro Gin Arg Leu Val Arg Arg Tyr Arg Asn Ala Arg Glu Gly Asp Ile 100 105 110

Ala Gly Val Ala Glu Arg Val Phe Asp Thr Trp Arg Cys Thr Leu Arg

115 120 125

Thr Thr Leu Leu Asp Phe Ala His Gly Val Val Asp Cys Phe Ala Pro 130 135 140 Gly Gly Pro Ser Gly Pro Thr Ser Phe Pro Lys Tyr Ile Asp Trp Leu 145 150 155 160

Thr Cys Leu Gly Leu Val Pro He Leu Arg Lys Thr Arg Glu Gly Glu 165 170 175 Ala Thr Gin Arg Leu Gly Ala Phe Leu Arg Gin His Thr Leu Pro Arg

180 185 190

Gin Leu Ala Thr Val Ala Gly- Ala Ala Glu Arg Ala Gly Pro Gly Leu 195 200 205 Leu Glu Leu Ala Val Ala Phe Asp Ser Thr Arg Met Ala Glu Tyr Asp 210 215 220

Arg Val His Ile Tyr Tyr Asn His Arg Arg Gly Glu Trp Leu Val Arg 225 230 235 240

Asp Pro Val Ser Gly Gin Arg Gly Glu Cys Leu Val Leu Cys Pro Pro 245 250 255

Leu Trp Thr Gly Asp Arg Leu Val Phe Asp Ser Pro Val Gin Arg Leu

260 265 270

Cys Pro Glu Ile Val Ala Cys His Ala Leu Arg Glu His Ala His Ile 275 280 285 Cys Arg Leu Arg Asn Thr Ala Ser Val Lys Val Leu Leu Gly Arg Lys 290 295 300

Ser Asp Ser Gly Val Ala Gly Ala Ala Ala Arg Val Val Asn Lys Ala 305 310 315 320

Leu Gly Glu Asp Asp Glu Thr Lys Ala Gly Ser Ala Ala Ser Arg Leu 325 330 335

Val Arg Leu Ile Ile Met Lys Gly Met Arg His Val Gly Asp Ile Asn

340 345 350

Asp Thr Val Arg Ala Tyr Leu Asp Glu Ala Gly Gly His Leu Ile Asp 355 360 365 Thr Pro Ala Val Asp His Thr Leu Pro Gly Phe Gly Lys Gly Gly Thr 370 375 380

Gly Arg Gly Ser Ala Ala Gin Asp Pro Gly Ala Arg Pro Gin Gin Leu 385 390 395 400

Arg Gin Ala Phe Gin Thr Ala Val Val Asn Asn He Asn Gly Met Leu 405 410 415

Glu Gly Tyr Ile Asn Asn Leu Phe Gly Thr Ile Glu Arg Leu Arg Glu

420 425 430

Thr Asn Ala Gly Leu Ala Thr Gin Leu Gin Ala Arg Asp Arg Glu Leu 435 440 445 Arg Arg Ala Gin Ala Gly Ala Leu Glu Arg Glu Gin Arg Ala Ala Asp 450 455 460

Arg Ala Ala Gly Gly Gly Ala Gly Arg Pro Ala Glu Ala Asp Leu Leu 465 470 475 480

Arg Ala Asp Tyr Asp Ile Ile Asp Val Ser Lys Ser Met Asp Asp Asp 485 490 495

Thr Tyr Val Ala Asn Ser Phe Gin His Gin Tyr Ile Pro Ala Tyr Gly

500 505 510

Gin Asp Leu Glu Arg Leu Ser Arg Leu Trp Glu His Glu Leu Val Arg 515 520 525

Cys Phe Lys Ile Leu Arg His Arg Asn Asn Gin Gly Gin Glu Thr Ser

530 535. 540

Ile Ser Tyr Ser Ser Gly Ala Ile Ala Ser Phe Val Ala Pro Tyr Phe 545 550 555 560

Glu Tyr Val Leu Arg Ala Pro Arg Ala Gly Ala Leu Ile Thr Gly Ser

565 570 575

Asp Val Ile Leu Gly Glu Glu Glu Leu Trp Glu Ala Val Phe Lys Lys 580 585 590 Thr Arg Leu Gin Thr Tyr Leu Thr Asp Val Ala Ala Leu Phe Val Ala 595 600 605

Asp Val Gin His Ala Ala Leu Pro Arg Pro Pro Ser Pro Thr Pro Ala

610 615 620

Asp Phe Arg Ala Ser Asp Arg Gly Gly Ser Arg Ser Arg Thr Arg Thr 625 630 635 640

Arg Ser Arg Ser Pro Gly Arg Thr Pro Arg Gly Ala Pro Asp Gin Gly

645 650 655

Trp Gly Val Glu Arg Arg Asp Gly Arg Pro His Ala Arg Arg 660 665 670

(2) INFORMATION FOR SEQ ID NO: 293:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 710 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:293

Met Asp Val Lys Phe Lys Asn Ala Ser Ser Leu Asn Arg Thr Ala Gly 1 5 10 15 Leu Ala Pro Gly Cys Cys Gly Gly Gly Pro Gly Ala Arg Thr Ser Arg 20 25 30

Glu Pro Ser Pro Pro Asp Ala Ala Met Ala Ala Gin Arg Ala Arg Ala

35 40 45

Pro Ala Met Arg Thr Arg Gly Gly Asp Ala Ala Leu Cys Ala Pro Glu 50 55 60

Asp Gly Trp Val Lys Val His Pro Thr Pro Gly Thr Met Leu Phe Arg 65 70 75 80

Glu Ile Leu Leu Gly Gin Met Gly Tyr Thr Glu Gly Gin Gly Val Tyr 85 90 95

Asn Val Val Arg Ser Ser Glu Ala Ala Thr Arg Gin Leu Gin Ala Ala

100 _. 105 110

Ile Phe His Ala Leu Leu Asn Ala Thr Tyr Asp Leu Glu Glu Asp Trp 115 120 125

Arg Arg His Val Val Arg Leu Gin Pro Gin Arg Leu Val Arg Arg Tyr

130 135 140

Arg Asn Ala Arg Glu Gly Asp Ile Ala Gly Val Ala Glu Arg Val Phe 145 150 155 160 Asp Thr Trp Arg Cys Thr Leu Arg Thr Thr Leu Leu Asp Phe Ala His

165 170 175

Gly Val Val Asp Cys Phe Ala Pro Gly Gly Pro Ser Gly Pro Thr Ser

180 185 190

Phe Pro Lys Tyr Ile Asp Trp Leu Thr Cys Leu Gly Leu Val Pro Ile 195 200 205

Leu Arg Lys Thr Arg Glu Gly Glu Ala Thr Gin Arg Leu Gly Ala Phe

210 215 220

Leu Arg Gin His Thr Leu Pro Arg Gin Leu Ala Thr Val Ala Gly Ala 225 230 235 240 Ala Glu Arg Ala Gly Pro Gly Leu Leu Glu Leu Ala Val Ala Phe Asp

245 250 255

Ser Thr Arg Met Ala Glu Tyr Asp Arg Val His Ile Tyr Tyr Asn His

260 265 270

Arg Arg Gly Glu Trp Leu Val Arg Asp Pro Val Ser Gly Gin Arg Gly 275 280 285

Glu Cys Leu Val Leu Cys Pro Pro Leu Trp Thr Gly Asp Arg Leu Val

290 295 300

Phe Asp Ser Pro Val Gin Arg Leu Cys Pro Glu Ile Val Ala Cys His 305 310 315 320 Ala Leu Arg Glu His Ala His Ile Cys Arg Leu Arg Asn Thr Ala Ser

325 330 335

Val Lys Val Leu Leu Gly Arg Lys Ser Asp Ser Gly Val Ala Gly Ala

340 345 350

Ala Arg Val Val Asn Lys Ala Leu Gly Glu Asp Asp Glu Thr Lys Ala 355 360 365

Gly Ser Ala Ala Ser Arg Leu Val Arg Leu Ile Ile Asn Met Lys Gly

370 375 380

Met Arg His Val Gly Asp Ile Asn Asp Thr Val Arg Ala Tyr Leu Asp 385 390 395 400 Glu Ala Gly Gly His Leu Ile Asp Thr Pro Ala Val Asp His Thr Leu

405 410 415

Pro Gly Phe Gly Lys Gly Gly Thr Gly Arg Gly Ser Ala Ala Gin Asp 420 425 430 Pro Gly Ala Arg Pro Gin Gin Leu Arg Gin Ala Phe Gin Thr Ala Val

435 440 445

Val Asn Asn Ile Asn Gly Met_. Leu Glu Gly Tyr Ile Asn Asn Leu Phe

450 455 460 Gly Thr Ile Glu Arg Leu Arg Glu Thr Asn Ala Gly Leu Ala Thr Gin

465 470 475 480

Leu Gin Ala Arg Asp Arg Glu Leu Arg Arg Ala Gin Ala Gly Ala Leu

485 490 495

Glu Arg Glu Gin Arg Ala Ala Asp Arg Ala Ala Gly Gly Gly Ala Gly 500 505 510

Arg Pro Ala Glu Ala Asp Leu Leu Arg Ala Asp Tyr Asp He Ile Asp

515 520 525

Val Ser Lys Ser Met Asp Asp Asp Thr Tyr Val Ala Asn Ser Phe Gin

530 535 540 His Gin Tyr Ile Pro Ala Tyr Gly Gin Asp Leu Glu Arg Leu Ser Arg

545 550 555 560

Leu Trp Glu His Glu Leu Val Arg Cys Phe Lys Ile Leu Arg His Arg

565 570 575

Asn Asn Gin Gly Gin Glu Thr Ser Ile Ser Tyr Ser Ser Gly Ala Ile 580 585 590

Ala Ser Phe Val Ala Pro Tyr Phe Glu Tyr Val Leu Arg Ala Pro Arg

595 600 605

Ala Gly Ala Leu Ile Thr Gly Ser Asp Val Ile Leu Gly Glu Glu Glu

610 615 620 Leu Trp Glu Ala Val Phe Lys Lys Thr Arg Leu Gin Thr Tyr Leu Thr

625 630 635 640

Asp Val Ala Ala Leu Phe Val Ala Asp Val Gin His Ala Ala Leu Pro

645 650 655

Arg Pro Pro Ser Pro Thr Pro Ala Asp Phe Arg Ala Ser Asp Arg Gly 660 665 670

Gly Ser Arg Ser Arg Thr Arg Thr Arg Ser Arg Ser Pro Gly Arg Thr

675 680 685

Pro Arg Gly Ala Pro Asp Gin Gly Trp Gly Val Glu Arg Arg Asp Gly 690 695 700 Arg Pro His Ala Arg Arg 705 710

(2) INFORMATION FOR SEQ ID NO: 294:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 720 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 294:

Met Arg Ala Met Ile Gly Trp Thr Pro Cys Met Asp Val Lys Phe Lys

1 5 10 15

Asn Ala Ser Ser Leu Asn Arg Thr Ala Gly Leu Ala Pro Gly Cys Cys 20 25 30

Gly Gly Gly Pro Gly Ala Arg Thr Ser Arg Glu Pro Ser Pro Pro Asp

35 40 45

Ala Ala Met Ala Ala Gin Arg Ala Arg Ala Pro Ala Met Arg Thr Arg 50 55 60 Gly Gly Asp Ala Ala Leu Cys Ala Pro Glu Asp Gly Trp Val Lys Val 65 70 75 80

His Pro Thr Pro Gly Thr Met Leu Phe Arg Glu Ile Leu Leu Gly Gin

85 90 95

Met Gly Tyr Thr Glu Gly Gin Gly Val Tyr Asn Val Val Arg Ser Ser 100 105 110

Glu Ala Ala Thr Arg Gin Leu Gin Ala Ala Ile Phe His Ala Leu Leu

115 120 125

Asn Ala Thr Tyr Asp Leu Glu Glu Asp Trp Arg Arg His Val Val Arg

130 135 140 Leu Gin Pro Gin Arg Leu Val Arg Arg Tyr Arg Asn Ala Arg Glu Gly

145 150 155 160

Asp Ile Ala Gly Val Ala Glu Arg Val Phe Asp Thr Trp Arg Cys Thr

165 170 175

Leu Arg Thr Thr Leu Leu Asp Phe Ala His Gly Val Val Asp Cys Phe 180 185 190

Ala Pro Gly Gly Pro Ser Gly Pro Thr Ser Phe Pro Lys Tyr Ile Asp

195 200 205

Trp Leu Thr Cys Leu Gly Leu Val Pro Ile Leu Arg Lys Thr Arg Glu

210 215 220 Gly Glu Ala Thr Gin Arg Leu Gly Ala Phe Leu Arg Gin His Thr Leu

225 230 235 240

Pro Arg Gin Leu Ala Thr Val Ala Gly Ala Ala Glu Arg Ala Gly Pro

245 250 255

Gly Leu Leu Glu Leu Ala Val Ala Phe Asp Ser Thr Arg Met Ala Glu 260 265 270

Tyr Asp Arg Val His Ile Tyr Tyr Asn His Arg Arg Gly Glu Trp Leu

275 280 285

Val Arg Asp Pro Val Ser Gly Gin Arg Gly Glu Cys Leu Val Leu Cys 290 295 300

Pro Pro Leu Trp Thr Gly Asp Arg Leu Val Phe Asp Ser Pro Val Gin

305 310 _ 315 320

Arg Leu Cys Pro Glu Ile Val Ala Cys His Ala Leu Arg Glu His Ala 325 330 335

His Ile Cys Arg Leu Arg Asn Thr Ala Ser Val Lys Val Leu Leu Gly 340 345 350

Arg Lys Ser Asp Ser Gly Val Ala Gly Ala Ala Arg Val Val Asn Lys 355 360 365

Ala Leu Gly Glu Asp Asp Glu Thr Lys Ala Gly Ser Ala Ala Ser Arg 370 375 380

Leu Val Arg Leu Ile He Asn Met Lys Gly Met Arg His Val Gly Asp

385 390 395 400

Ile Asn Asp Thr Val Arg Ala Tyr Leu Asp Glu Ala Gly Gly His Leu 405 410 415

Ile Asp Thr Pro Ala Val Asp His Thr Leu Pro Gly Phe Gly Lys Gly 420 425 430

Gly Thr Gly Arg Gly Ser Ala Ala Gin Asp Pro Gly Ala Arg Pro Gin

435 440 445

Gin Leu Arg Gin Ala Phe Gin Thr Ala Val Val Asn Asn Ile Asn Gly 450 455 460

Met Leu Glu Gly Tyr He Asn Asn Leu Phe Gly Thr Ile Glu Arg Leu

465 470 475 480

Arg Glu Thr Asn Ala Gly Leu Ala Thr Gin Leu Gin Ala Arg Asp Arg 485 490 495

Glu Leu Arg Arg Ala Gin Ala Gly Ala Leu Glu Arg Glu Gin Arg Ala 500 505 510

Ala Asp Arg Ala Ala Gly Gly Gly Ala Gly Arg Pro Ala Glu Ala Asp

515 520 525

Leu Leu Arg Ala Asp Tyr Asp Ile Ile Asp Val Ser Lys Ser Met Asp 530 535 540

Asp Asp Thr Tyr Val Ala Asn Ser Phe Gin His Gin Tyr Ile Pro Ala

545 550 555 560

Tyr Gly Gin Asp Leu Glu Arg Leu Ser Arg Leu Trp Glu His Glu Leu 565 570 575

Val Arg Cys Phe Lys Ile Leu Arg His Arg Asn Asn Gin Gly Gin Glu 580 585 590

Thr Ser Ile Ser Tyr Ser Ser Gly Ala Ile Ala Ser Phe Val Ala Pro 595 600 605

Tyr Phe Glu Tyr Val Leu Arg Ala Pro Arg Ala Gly Ala Leu Ile Thr 610 615 620

Gly Ser Asp Val Ile Leu Gly Glu Glu Glu Leu Trp Glu Ala Val Phe

625 630 635 640 Lys Lys Thr Arg Leu Gin Thr Tyr Leu Thr Asp Val Ala Ala Leu Phe

645 650 655

Val Ala Asp Val Gin His Ala Ala Leu Pro Arg Pro Pro Ser Pro Thr 660 665 670 Pro Ala Asp Phe Arg Ala Ser Asp Arg Gly Gly Ser Arg Ser Arg Thr 675 680 685

Arg Thr Arg Ser Arg Ser Pro Gly Arg Thr Pro Arg Gly Ala Pro Asp

690 695 700

Gin Gly Trp Gly Val Glu Arg Arg Asp Gly Arg Pro His Ala Arg Arg 705 710 715 720

(2) INFORMATION FOR SEQ ID NO: 295:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 763 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 295:

Met Arg Tyr Ala Ala Asn Gly Asn Ser Arg Ser Gly Arg Pro Val Gly 1 5 10 15

Thr Ser Lys Ala Ala Thr Ser Arg Asn His Cys Arg Arg Gly Thr Cys

20 25 30

Val Thr Ser Ser Cys Cys Cys Glu Ser Ser Arg Met Arg Ala Met Ile 35 , 40 45 Gly Trp Thr Pro Cys Met Asp Val Lys Phe Lys Asn Ala Ser Ser Leu 50 55 60

Asn Arg Thr Ala Gly Leu Ala Pro Gly Cys Cys Gly Gly Gly Pro Gly 65 70 75 80

Ala Arg Thr Ser Arg Glu Pro Ser Pro Pro Asp Ala Ala Met Ala Ala 85 90 95

Gin Arg Ala Arg Ala Pro Ala Met Arg Thr Arg Gly Gly Asp Ala Ala

100 105 110

Leu Cys Ala Pro Glu Asp Gly Trp Val Lys Val His Pro Thr Pro Gly 115 120 125 Thr Met Leu Phe Arg Glu Ile Leu Leu Gly Gin Met Gly Tyr Thr Glu 130 135 140

Gly Gin Gly Val Tyr Asn Val Val Arg Ser Ser Glu Ala Ala Thr Arg 145 150 155 160 Gin Leu Gin Ala Ala Ile Phe His Ala Leu Leu Asn Ala Thr Tyr Asp

165 170 175

Leu Glu Glu Asp Trp Arg Arg His Val Val Arg Leu Gin Pro Gin Arg 180 185 190 Leu Val Arg Arg Tyr Arg Asn Ala Arg Glu Gly Asp Ile Ala Gly Val 195 200 205

Ala Glu Arg Val Phe Asp Thr Trp Arg Cys Thr Leu Arg Thr Thr Leu

210 215 220

Leu Asp Phe Ala His Gly Val Val Asp Cys Phe Ala Pro Gly Gly Pro 225 230 235 240

Ser Gly Pro Thr Ser Phe Pro Lys Tyr Ile Asp Trp Leu Thr Cys Leu

245 250 255

Gly Leu Val Pro Ile Leu Arg Lys Thr Arg Glu Gly Glu Ala Thr Gin 260 265 270 Arg Leu Gly Ala Phe Leu Arg Gin His Thr Leu Pro Arg Gin Leu Ala 275 280 285

Thr Val Ala Gly Ala Ala Glu Arg Ala Gly Pro Gly Leu Leu Glu Leu

290 295 300

Ala Val Ala Phe Asp Ser Thr Arg Met Ala Glu Tyr Asp Arg Val His 305 310 315 320 lie Tyr Tyr Asn His Arg Arg Gly Glu Trp Leu Val Arg Asp Pro Val

325 330 335

Ser Gly Gin Arg Gly Glu Cys Leu Val Leu Cys Pro Pro Leu Trp Thr 340 345 350 Gly Asp Arg Leu Val Phe Asp Ser Pro Val Gin Arg Leu Cys Pro Glu 355 360 365

Ile Val Ala Cys His Ala Leu Arg Glu His Ala His Ile Cys Arg Leu

370 375 380

Arg Asn Thr Ala Ser Val Lys Val Leu Leu Gly Arg Lys Ser Asp Ser 385 390 395 400

Gly Val Ala Gly Ala Ala Arg Val Val Asn Lys Ala Leu Gly Glu Asp

405 410 415

Asp Glu Thr Lys Ala Gly Ser Ala Ala Ser Arg Leu Val Arg Leu Ile 420 425 430 Ile Asn Met Lys Gly Met Arg His Val Gly Asp Ile Asn Asp Thr Val 435 440 445

Arg Ala Tyr Leu Asp Glu Ala Gly Gly His Leu Ile Asp Thr Pro Ala

450 455 460

Val Asp His Thr Leu Pro Gly Phe Gly Lys Gly Gly Thr Gly Arg Gly 465 470 475 480

Ser Ala Ala Gin Asp Pro Gly Ala Arg Pro Gin Gin Leu Arg Gin Ala

485 490 495

Phe Gin Thr Ala Val Val Asn Asn Ile Asn Gly Met Leu Glu Gly Tyr 500 505 510

Ile Asn Asn Leu Phe Gly Thr Ile Glu Arg Leu Arg Glu Thr Asn Ala

515 . 520 525

Gly Leu Ala Thr Gin Leu Gin Ala Arg Asp Arg Glu Leu Arg Arg Ala 530 535 540

Gin Ala Gly Ala Leu Glu Arg Glu Gin Arg Ala Ala Asp Arg Ala Ala

545 550 555 560

Gly Gly Gly Ala Gly Arg Pro Ala Glu Ala Asp Leu Leu Arg Ala Asp

565 570 575 Tyr Asp Ile Ile Asp Val Ser Lys Ser Met Asp Asp Asp Thr Tyr Val

580 585 590

Ala Asn Ser Phe Gin His Gin Tyr Ile Pro Ala Tyr Gly Gin Asp Leu

595 600 605

Glu Arg Leu Ser Arg Leu Trp Glu His Glu Leu Val Arg Cys Phe Lys 610 615 620

Ile Leu Arg His Arg Asn Asn Gin Gly Gin Glu Thr Ser Ile Ser Tyr

625 630 635 640

Ser Ser Gly Ala Ile Ala Ser Phe Val Ala Pro Tyr Phe Glu Tyr Val

645 650 655 Leu Arg Ala Pro Arg Ala Gly Ala Leu Ile Thr Gly Ser Asp Val Ile

660 665 670

Leu Gly Glu Glu Glu Leu Trp Glu Ala Val Phe Lys Lys Thr Arg Leu

675 680 685

Gin Thr Tyr Leu Thr Asp Val Ala Ala Leu Phe Val Ala Asp Val Gin 690 695 700

His Ala Ala Leu Pro Arg Pro Pro Ser Pro Thr Pro Ala Asp Phe Arg 705 710 715 720

Ala Ser Asp Arg Gly Gly Ser Arg Ser Arg Thr Arg Thr Arg Ser Arg 725 730 735 Ser Pro Gly Arg Thr Pro Arg Gly Ala Pro Asp Gin Gly Trp Gly Val 740 745 750

Glu Arg Arg Asp Gly Arg Pro His Ala Arg Arg 755 760

(2) INFORMATION FOR SEQ ID NO: 296:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 414 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:296:

Met Ala Asp Ile Pro Pro Asp Pro Pro Ala Leu Asn Thr Thr Pro Ala 1 5 10 15

Asn His Ala Pro Pro Ser Pro Pro Pro Gly Ser Arg Lys Arg Arg Arg

20 25 30

Pro Val Leu Pro Ser Ser Ser Glu Ser Glu Gly Lys Pro Asp Thr Glu 35 40 45 Ser Glu Ser Ser Ser Thr Glu Ser Ser Glu Asp Glu Ala Gly Asp Leu 50 55 60

Arg Gly Gly Arg Arg Arg Ser Pro Arg Glu Leu Gly Gly Arg Tyr Phe 65 70 75 80

Leu Asp Leu Ser Ala Glu Ser Thr Thr Gly Thr Glu Ser Glu Gly Thr 85 90 95

Gly Pro Ser Asp Asp Asp Asp Asp Asp Ala Ser Asp Gly Trp Leu Val

100 105 110

Asp Thr Pro Pro Arg Lys Ser Lys Arg Pro Arg Ile Asn Leu Arg Leu 115 120 125 Thr Ser Ser Pro Asp Arg Arg Ala Gly Val Val Phe Pro Glu Val Trp 130 135 140

Arg Asn Asp Arg Pro Ile Arg Ala Ala Gin Pro Gin Ala Pro Ala Gin 145 150 155 160

Ser Ser Gly Asp Arg Ala Ala Ala Pro Arg Arg Ser Ala Arg Gin Ala 165 170 175

Gin Met Arg Ser Gly Ala Ala Trp Thr Leu Asp Leu His Tyr Ile Arg

180 185 190

Gin Cys Val Asn Gin Leu Phe Arg Ile Leu Arg Ala Ala Pro Asn Pro 195 200 205 Pro Gly Ser Ala Asn Arg Leu Arg His Leu Val Arg Asp Cys Tyr Leu 210 215 220

Met Gly Tyr Cys Arg Thr Arg Leu Gly Pro Arg Thr Trp Gly Arg Leu 225 230 235 240

Leu Gin Ile Ser Gly Gly Thr Trp Asp Val Arg Leu Arg Asn Ala Ile 245 250 255

Arg Glu Val Glu Ala Arg Phe Glu Pro Ala Ala Glu Pro Val Cys Glu

260 265 270

Leu Pro Cys Leu Asn Ala Arg Arg Tyr Gly Pro Glu Cys Asp Val Gly 275 280 285 Asn Leu Glu Thr Asn Gly Gly Ser Thr Ser Asp Asp Glu Ile Ser Asp 290 295 300

Ala Thr Asp Ser Asp Asp Thr Leu Ala Ser His Ser Asp Thr Glu Gly 305 310 315 320 Gly Pro Ser Pro Ala Gly Arg Glu Asn Pro Glu Ser Ala Ser Gly Gly

325 330 335

Ala lie Ala Ala Arg Leu Glu. Cys Glu Phe Gly Thr Phe Asp Trp Thr

340 345 350

Ser Glu Glu Gly Ser Gin Pro Trp Leu Ser Ala Val Val Ala Asp Thr

355 360 365

Ser Ser Ala Glu Arg Ser Gly Leu Pro Ala Pro Gly Ala Cys Arg Ala

370 375 380

Thr Glu Ala Pro Glu Arg Glu Asp Gly Cys Arg Lys Met Arg Phe Pro 385 390 395 400

Ala Ala Cys Pro Tyr Pro Cys Gly His Thr Phe Leu Arg Pro 405 410

(2) INFORMATION FOR SEQ ID NO: 297:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 810 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 297:

Met Gly Arg Leu Arg Asn Ala Pro Glu Ser Leu Thr Tyr Met Phe Cys

1 5 10 15

Ala Ala Ile Arg Val Ala Pro Val Thr Thr Gin Ser Arg Thr Ser Leu 20 25 30 Arg Val Cys Thr His Val Leu Phe Pro Asp Pro Ala Leu Pro Val Met 35 40 45

Arg Tyr Ala Ala Asn Gly Asn Ser Arg Ser Gly Arg Pro Val Gly Thr

50 55 60

Ser Lys Ala Ala Thr Ser Arg Asn His Cys Arg Arg Gly Thr Cys Val 65 70 75 80

Thr Ser Ser Cys Cys Cys Glu Ser Ser Arg Met Arg Ala Met Ile Gly

85 90 95

Trp Thr Pro Cys Met Asp Val Lys Phe Lys Asn Ala Ser Ser Leu Asn 100 105 110 Arg Thr Ala Gly Leu Ala Pro Gly Cys Cys Gly Gly Gly Pro Gly Ala 115 120 125

Arg Thr Ser Arg Glu Pro Ser Pro Pro Asp Ala Ala Met Ala Ala Gin 130 135 140 Arg Ala Arg Ala Pro Ala Met Arg Thr Arg Gly Gly Asp Ala Ala Leu

145 150 155 160

Cys Ala Pro Glu Asp Gly Trp .Val Lys Val His Pro Thr Pro Gly Thr

165 170 175 Met Leu Phe Arg Glu Ile Leu Leu Gly Gin Met Gly Tyr Thr Glu Gly

180 185 190

Gin Gly Val Tyr Asn Val Val Arg Ser Ser Glu Ala Ala Thr Arg Gin

195 200 205

Leu Gin Ala Ala Ile Phe His Ala Leu Leu Asn Ala Thr Tyr Asp Leu 210 215 220

Glu Glu Asp Trp Arg Arg His Val Val Arg Leu Gin Pro Gin Arg Leu

225 230 235 240

Val Arg Arg Tyr Arg Asn Ala Arg Glu Gly Asp Ile Ala Gly Val Ala

245 250 255 Glu Arg Val Phe Asp Thr Trp Arg Cys Thr Leu Arg Thr Thr Leu Leu

260 265 270

Asp Phe Ala His Gly Val Val Asp Cys Phe Ala Pro Gly Gly Pro Ser

275 280 285

Gly Pro Thr Ser Phe Pro Lys Tyr Ile Asp Trp Leu Thr Cys Leu Gly 290 295 300

Leu Val Pro Ile Leu Arg Lys Thr Arg Glu Gly Glu Ala Thr Gin Arg

305 310 315 320

Leu Gly Ala Phe Leu Arg Gin His Thr Leu Pro Arg Gin Leu Ala Thr

325 330 335 Val Ala Gly Ala Ala Glu Arg Ala Gly Pro Gly Leu Leu Glu Leu Ala

340 345 350

Val Ala Phe Asp Ser Thr Arg Met Ala Glu Tyr Asp Arg Val His Ile

355 360 365

Tyr Tyr Asn His Arg Arg Gly Glu Trp Leu Val Arg Asp Pro Val Ser 370 375 380

Gly Gin Arg Gly Glu Cys Leu Val Leu Cys Pro Pro Leu Trp Thr Gly

385 390 395 400

Asp Arg Leu Val Phe Asp Ser Pro Val Gin Arg Leu Cys Pro Glu Ile

405 410 415 Val Ala Cys His Ala Leu Arg Glu His Ala His Ile Cys Arg Leu Arg

420 425 430

Asn Thr Ala Ser Val Lys Val Leu Leu Gly Arg Lys Ser Asp Ser Gly

435 440 445

Val Ala Gly Ala Ala Arg Val Val Asn Lys Ala Leu Gly Glu Asp Asp 450 455 460

Glu Thr Lys Ala Gly Ser Ala Ala Ser Arg Leu Val Arg Leu Ile Ile 465 470 475 480

Asn Met Lys Gly Met Arg His Val Gly Asp Ile Asn Asp Thr Val Arg 485 490 495

Ala Tyr Leu Asp Glu Ala Gly Gly His Leu Ile Asp Thr Pro Ala Val

500 - 505 510

Asp His Thr Leu Pro Gly Phe Gly Lys Gly Gly Thr Gly Arg Gly Ser 515 520 525

Ala Ala Gin Asp Pro Gly Ala Arg Pro Gin Gin Leu Arg Gin Ala Phe

530 535 540

Gin Thr Ala Val Val Asn Asn Ile Asn Gly Met Leu Glu Gly Tyr Ile 545 550 555 560 Asn Asn Leu Phe Gly Thr Ile Glu Arg Leu Arg Glu Thr Asn Ala Gly

565 570 575

Leu Ala Thr Gin Leu Gin Ala Arg Asp Arg Glu Leu Arg Arg Ala Gin

580 585 590

Ala Gly Ala Leu Glu Arg Glu Gin Arg Ala Ala Asp Arg Ala Ala Gly 595 600 605

Gly Gly Ala Gly Arg Pro Ala Glu Ala Asp Leu Leu Arg Ala Asp Tyr

610 615 620

Asp Ile Ile Asp Val Ser Lys Ser Met Asp Asp Asp Thr Tyr Val Ala 625 630 635 640 Asn Ser Phe Gin His Gin Tyr Ile Pro Ala Tyr Gly Gin Asp Leu Glu

645 650 655

Arg Leu Ser Arg Leu Trp Glu His Glu Leu Val Arg Cys Phe Lys Ile

660 665 670

Leu Arg His Arg Asn Asn Gin Gly Gin Glu Thr Ser Ile Ser Tyr Ser 675 680 685

Ser Gly Ala Ile Ala Ser Phe Val Ala Pro Tyr Phe Glu Tyr Val Leu

690 695 700

Arg Ala Pro Arg Ala Gly Ala Leu Ile Thr Gly Ser Asp Val Ile Leu 705 710 715 720 Gly Glu Glu Glu Leu Trp Glu Ala Val Phe Lys Lys Thr Arg Leu Gin

725 730 735

Thr Tyr Leu Thr Asp Val Ala Ala Leu Phe Val Ala Asp Val Gin His

740 745 750

Ala Ala Leu Pro Arg Pro Pro Ser Pro Thr Pro Ala Asp Phe Arg Ala 755 760 765

Ser Asp Arg Gly Gly Ser Arg Ser Arg Thr Arg Thr Arg Ser Arg Ser

770 775 780

Pro Gly Arg Thr Pro Arg Gly Ala Pro Asp Gin Gly Trp Gly Val Glu 785 790 795 800 Arg Arg Asp Gly Arg Pro His Ala Arg Arg

805 810

(2) INFORMATION FOR SEQ ID NO: 298: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 813 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 298:

Met Val Leu Met Gly Arg Leu Arg Asn Ala Pro Glu Ser Leu Thr Tyr

1 5 10 15

Met Phe Cys Ala Ala Ile Arg Val Ala Pro Val Thr Thr Gin Ser Arg 20 25 30

Thr Ser Leu Arg Val Cys Thr His Val Leu Phe Pro Asp Pro Ala Leu

35 40 45

Pro Val Met Arg Tyr Ala Ala Asn Gly Asn Ser Arg Ser Gly Arg Pro 50 55 60 Val Gly Thr Ser Lys Ala Ala Thr Ser Arg Asn His Cys Arg Arg Gly 65 70 75 80

Thr Cys Val Thr Ser Ser Cys Cys Cys Glu Ser Ser Arg Met Arg Ala

85 90 95

Met Ile Gly Trp Thr Pro Cys Met Asp Val Lys Phe Lys Asn Ala Ser 100 105 110

Ser Leu Asn Arg Thr Ala Gly Leu Ala Pro Gly Cys Cys Gly Gly Gly

115 120 125

Pro Gly Ala Arg Thr Ser Arg Glu Pro Ser Pro Pro Asp Ala Ala Met

130 135 140 Ala Ala Gin Arg Ala Arg Ala Pro Ala Met Arg Thr Arg Gly Gly Asp

145 150 155 160

Ala Ala Leu Cys Ala Pro Glu Asp Gly Trp Val Lys Val His Pro Thr

165 170 175

Pro Gly Thr Met Leu Phe Arg Glu Ile Leu Leu Gly Gin Met Gly Tyr 180 185 190

Thr Glu Gly Gin Gly Val Tyr Asn Val Val Arg Ser Ser Glu Ala Ala

195 200 205

Thr Arg Gin Leu Gin Ala Ala Ile Phe His Ala Leu Leu Asn Ala Thr 210 215 220 Tyr Asp Leu Glu Glu Asp Trp Arg Arg His Val Val Arg Leu Gin Pro 225 230 235 240

Gin Arg Leu Val Arg Arg Tyr Arg Asn Ala Arg Glu Gly Asp Ile Ala 245 250 255 Gly Val Ala Glu Arg Val Phe Asp Thr Trp Arg Cys Thr Leu Arg Thr

260 265 270

Thr Leu Leu Asp Phe Ala His. Gly Val Val Asp Cys Phe Ala Pro Gly 275 280 285 Gly Pro Ser Gly Pro Thr Ser Phe Pro Lys Tyr Ile Asp Trp Leu Thr 290 295 300

Cys Leu Gly Leu Val Pro Ile Leu Arg Lys Thr Arg Glu Gly Glu Ala 305 310 315 320

Thr Gin Arg Leu Gly Ala Phe Leu Arg Gin His Thr Leu Pro Arg Gin 325 330 335

Leu Ala Thr Val Ala Gly Ala Ala Glu Arg Ala Gly Pro Gly Leu Leu

340 345 350

Glu Leu Ala Val Ala Phe Asp Ser Thr Arg Met Ala Glu Tyr Asp Arg 355 360 365 Val His Ile Tyr Tyr Asn His Arg Arg Gly Glu Trp Leu Val Arg Asp 370 375 380

Pro Val Ser Gly Gin Arg Gly Glu Cys Leu Val Leu Cys Pro Pro Leu 385 390 395 400

Trp Thr Gly Asp Arg Leu Val Phe Asp Ser Pro Val Gin Arg Leu Cys 405 410 415

Pro Glu Ile Val Ala Cys His Ala Leu Arg Glu His Ala His Ile Cys

420 425 430

Arg Leu Arg Asn Thr Ala Ser Val Lys Val Leu Leu Gly Arg Lys Ser 435 440 445 Asp Ser Gly Val Ala Gly Ala Ala Arg Val Val Asn Lys Ala Leu Gly 450 455 460

Glu Asp Asp Glu Thr Lys Ala Gly Ser Ala Ala Ser Arg Leu Val Arg 465 470 475 480

Leu Ile Ile Asn Met Lys Gly Met Arg His Val Gly Asp Ile Asn Asp 485 490 495

Thr Val Arg Ala Tyr Leu Asp Glu Ala Gly Gly His Leu Ile Asp Thr

500 505 510

Pro Ala Val Asp His Thr Leu Pro Gly Phe Gly Lys Gly Gly Thr Gly 515 520 525 Arg Gly Ser Ala Ala Gin Asp Pro Gly Ala Arg Pro Gin Gin Leu Arg 530 535 540

Gin Ala Phe Gin Thr Ala Val Val Asn Asn Ile Asn Gly Met Leu Glu 545 550 555 560

Gly Tyr Ile Asn Asn Leu Phe Gly Thr Ile Glu Arg Leu Arg Glu Thr 565 570 575

Asn Ala Gly Leu Ala Thr Gin Leu Gin Ala Arg Asp Arg Glu Leu Arg

580 585 590

Arg Ala Gin Ala Gly Ala Leu Glu Arg Glu Gin Arg Ala Ala Asp Arg 595 600 605

Ala Ala Gly Gly Gly Ala Gly Arg Pro Ala Glu Ala Asp Leu Leu Arg 610 615 620 Ala Asp Tyr Asp Ile Ile Asp Val Ser Lys Ser Met Asp Asp Asp Thr 625 630 635 640 Tyr Val Ala Asn Ser Phe Gin His Gin Tyr Ile Pro Ala Tyr Gly Gin 645 650 655

Asp Leu Glu Arg Leu Ser Arg Leu Trp Glu His Glu Leu Val Arg Cys 660 665 670

Phe Lys Ile Leu Arg His Arg Asn Asn Gin Gly Gin Glu Thr Ser Ile 675 680 685

Ser Tyr Ser Ser Gly Ala Ile Ala Ser Phe Val Ala Pro Tyr Phe Glu 690 695 700 Tyr Val Leu Arg Ala Pro Arg Ala Gly Ala Leu Ile Thr Gly Ser Asp 705 710 715 720 Val Ile Leu Gly Glu Glu Glu Leu Trp Glu Ala Val Phe Lys Lys Thr 725 730 735

Arg Leu Gin Thr Tyr Leu Thr Asp Val Ala Ala Leu Phe Val Ala Asp 740 745 750

Val Gin His Ala Ala Leu Pro Arg Pro Pro Ser Pro Thr Pro Ala Asp 755 760 765

Phe Arg Ala Ser Asp Arg Gly Gly Ser Arg Ser Arg Thr Arg Thr Arg 770 775 780 Ser Arg Ser Pro Gly Arg Thr Pro Arg Gly Ala Pro Asp Gin Gly Trp 785 790 795 800 Gly Val Glu Arg Arg Asp Gly Arg Pro His Ala Arg Arg 805 810

(2) INFORMATION FOR SEQ ID NO: 299:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 470 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 299:

Met Ala Leu Gly Arg Val Gly Leu Ala Val Gly Leu Trp Gly Leu Leu

1 5 10 15

Trp Val Gly Val Val Val Val Leu Ala Asn Asp Gly Arg Thr Ile Thr 20 25 30

Val Gly Pro Arg Gly Asn Asn Ala Ala Pro Ser Asp Arg Asn Ala Ser

35 - 40 45

Ala Pro Arg Thr Thr Pro Thr Pro Pro Gin Pro Arg Lys Ala Thr Lys 50 55 60

Ser Lys Ala Ser Thr Ala Lys Pro Ala Pro Pro Pro Lys Thr Gly Pro 65 70 75 80

Pro Lys Thr Ser Ser Glu Pro Val Arg Cys Asn Arg His Asp Pro Leu 85 90 95 Ala Arg Tyr Gly Ser Arg Val Gin Ile Arg Cys Arg Phe Pro Asn Ser 100 105 110

Thr Arg Thr Glu Ser Arg Leu Gin Ile Trp Arg Tyr Ala Thr Ala Thr

115 120 125

Asp Ala Glu Ile Gly Thr Ala Pro Ser Leu Glu Glu Val Met Val Asn 130 135 140

Val Ser Ala Pro Pro Gly Gly Gin Leu Val Tyr Asp Ser Ala Pro Asn

145 150 155 160

Arg Thr Asp Pro His Val Ile Trp Ala Glu Gly Ala Gly Pro Gly Asp

165 170 175 Arg Lys Val Val Gly Pro Leu Gly Arg Gin Arg Leu Ile Ile Glu Glu

180 185 190

Leu Thr Leu Glu Thr Gin Gly Met Tyr Tyr Trp Val Trp Gly Arg Thr

195 200 205

Asp Arg Pro Ser Ala Tyr Gly Thr Trp Val Arg Val Arg Val Phe Arg 210 215 220

Pro Pro Ser Leu Thr Ile His Pro His Ala Val Leu Glu Gly Gin Pro

225 230 235 240

Phe Lys Ala Thr Cys Thr Ala Ala Thr Tyr Tyr Pro Gly Asn Arg Ala

245 250 255 Glu Phe Val Trp Phe Glu Asp Gly Arg Arg Val Phe Asp Pro Ala Gin

260 265 270

Ile His Thr Gin Thr Gin Glu Asn Pro Asp Gly Phe Ser Thr Val Ser

275 280 285

Thr Val Thr Ser Ala Ala Val Gly Gly Gin Gly Pro Pro Arg Thr Phe 290 295 300

Thr Cys Gin Leu Thr Trp His Arg Asp Ser Val Ser Phe Ser Arg Arg 305 310 315 320

Asn Ala Ser Gly Thr Ala Ser Val Leu Pro Arg Pro Thr Ile Thr Met 325 330 335 Glu Phe Thr Gly Asp His Ala Val Cys Thr Ala Gly Cys Val Pro Glu 340 345 350

Gly Val Thr Phe Ala Trp Phe Leu Gly Asp Asp Ser Ser Pro Ala Glu 355 360 365 Lys Val Ala Val Ala Ser Gin Thr Ser Cys Gly Arg Pro Gly Thr Ala

370 375 380

Thr Ile Arg Ser Thr Leu Pro_. Val Ser Tyr Glu Gin Thr Glu Tyr Ile 385 390 395 400

Cys Arg Leu Ala Gly Tyr Pro Asp Gly Ile Pro Val Leu Glu His His

405 410 415

Gly Ser His Gin Pro Pro Pro Arg Asp Pro Thr Glu Arg Gin Val Ile

420 425 430

Arg Ala Val Glu Gly Ala Gly Ile Gly Val Ala Val Leu Val Ala Val

435 440 445

Val Leu Ala Gly Thr Ala Val Val Tyr Leu Thr His Ala Ser Ser Val

450 455 460

Arg Tyr Arg Arg Leu Arg 465 470

(2) INFORMATION FOR SEQ ID NO: 300:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 536 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 300:

Met Gly Ala Gly Val Pro Trp Thr Gly Ile Lys Arg Ala Gly Gly Pro 1 5 10 15 He Thr Val Arg Val Leu Gly Trp Glu Val Ala Gin Lys Ala Thr His 20 25 30

Pro Cys Cys Ser Cys Pro Arg Glu Ala Val Val Ser Gly Asn Pro Pro

35 40 45

Arg Cys Ala Gly Arg Ala His Arg Ser Phe Ala Gly Ala Gly Ala Leu 50 55 60

Leu Val Met Ala Leu Gly Arg Val Gly Leu Ala Val Gly Leu Trp Gly 65 70 75 80

Leu Leu Trp Val Gly Val Val Val Val Leu Ala Asn Asp Gly Arg Thr 85 90 95 Ile Thr Val Gly Pro Arg Gly Asn Asn Ala Ala Pro Ser Asp Arg Asn 100 105 110

Ala Ser Ala Pro Arg Thr Thr Pro Thr Pro Pro Gin Pro Arg Lys Ala 115 120 125 Thr Lys Ser Lys Ala Ser Thr Ala Lys Pro Ala Pro Pro Pro Lys Thr

130 135 140

Gly Pro Pro Lys Thr Ser Ser. Glu Pro Val Arg Cys Asn Arg His Asp 145 150 155 160 Pro Leu Ala Arg Tyr Gly Ser Arg Val Gin Ile Arg Cys Arg Phe Pro

165 170 175

Asn Ser Thr Arg Thr Glu Ser Arg Leu Gin Ile Trp Arg Tyr Ala Thr

180 185 190

Ala Thr Asp Ala Glu Ile Gly Thr Ala Pro Ser Leu Glu Glu Val Met 195 200 205

Val Asn Val Ser Ala Pro Pro Gly Gly Gin Leu Val Tyr Asp Ser Ala

210 215 220

Pro Asn Arg Thr Asp Pro His Val Ile Trp Ala Glu Gly Ala Gly Pro 225 230 235 240 Gly Asp Arg Lys Val Val Gly Pro Leu Gly Arg Gin Arg Leu Ile Ile

245 250 255

Glu Glu Leu Thr Leu Glu Thr Gin Gly Met Tyr Tyr Trp Val Trp Gly

260 265 270

Arg Thr Asp Arg Pro Ser Ala Tyr Gly Thr Trp Val Arg Val Arg Val 275 280 285

Phe Arg Pro Pro Ser Leu Thr Ile His Pro His Ala Val Leu Glu Gly

290 295 300

Gin Pro Phe Lys Ala Thr Cys Thr Ala Ala Thr Tyr Tyr Pro Gly Asn 305 310 315 320 Arg Ala Glu Phe Val Trp Phe Glu Asp Gly Arg Arg Val Phe Asp Pro

325 330 335

Ala Gin Ile His Thr Gin Thr Gin Glu Asn Pro Asp Gly Phe Ser Thr

340 345 350

Val Ser Thr Val Thr Ser Ala Ala Val Gly Gly Gin Gly Pro Pro Arg 355 360 365

Thr Phe Thr Cys Gin Leu Thr Trp His Arg Asp Ser Val Ser Phe Ser

370 375 380

Arg Arg Asn Ala Ser Gly Thr Ala Ser Val Leu Pro Arg Pro Thr Ile 385 390 395 400 Thr Met Glu Phe Thr Gly Asp His Ala Val Cys Thr Ala Gly Cys Val

405 410 415

Pro Glu Gly Val Thr Phe Ala Trp Phe Leu Gly Asp Asp Ser Ser Pro

420 425 430

Ala Glu Lys Val Ala Val Ala Ser Gin Thr Ser Cys Gly Arg Pro Gly 435 440 445

Thr Ala Thr Ile Arg Ser Thr Leu Pro Val Ser Tyr Glu Gin Thr Glu

450 455 460

Tyr Ile Cys Arg Leu Ala Gly Tyr Pro Asp Gly Ile Pro Val Leu Glu 465 470 475 480

His His Gly Ser His Gin Pro Pro Pro Arg Asp Pro Thr Glu Arg Gin

485 . 490 495

Val He Arg Ala Val Glu Gly Ala Gly Ile Gly Val Ala Val Leu Val

500 505 510

Ala Val Val Leu Ala Gly Thr Ala Val Val Tyr Leu Thr His Ala Ser

515 520 525

Ser Val Arg Tyr Arg Arg Leu Arg 530 535

(2) INFORMATION FOR SEQ ID NO: 301

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 545 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 301:

Met Ser Val Leu Gly Asp Ala Arg His Pro Arg Arg Phe Pro Ser Arg 1 5 10 15 Gly Pro Arg Pro Phe Ser Val Ala Gly Pro Gly Ser Leu Pro Pro Ser 20 25 30

Pro Pro Pro Gly Ala Arg Ala Arg Leu Ile Arg Leu Ser Arg Ser Leu

35 40 45

Phe Pro Asp Pro Thr Ala Pro Met Asp Leu Leu Val Asp Asp Leu Phe 50 55 60

Ala Asp Ala Asp Gly Val Ser Pro Pro Pro Pro Arg Pro Ala Gly Gly

65 70 75 80

Pro Lys Asn Thr Pro Ala Ala Pro Pro Leu Tyr Ala Thr Gly Arg Leu

85 90 95 Ser Gin Ala Gin Leu Met Pro Ser Pro Pro Met Pro Val Pro Pro Ala

100 105 110

Ala Leu Phe Asn Arg Leu Leu Asp Asp Leu Gly Phe Ser Ala Gly Pro

115 120 125

Ala Leu Cys Thr Met Leu Asp Thr Trp Asn Glu Asp Leu Phe Ser Gly 130 135 140

Phe Pro Thr Asn Ala Asp Met Tyr Arg Glu Cys Lys Phe Leu Ser Thr 145 150 155 160

Leu Pro Ser Asp Val Ile Asp Trp Gly Asp Ala His Val Pro Glu Arg 165 170 175

Ser Pro Ile Asp Ile Arg Ala His Gly Asp Val Ala Phe Pro Thr Leu

180 _. 185 190

Pro Ala Thr Arg Asp Glu Leu Pro Ser Tyr Tyr Glu Ala Met Ala Gin 195 200 205

Phe Phe Arg Gly Glu Leu Arg Ala Arg Glu Glu Ser Tyr Arg Thr Val

210 215 220

Leu Ala Asn Phe Cys Ser Ala Leu Tyr Arg Tyr Leu Arg Ala Ser Val 225 230 235 240 Arg Gin Leu His Arg Gin Ala His Met Arg Gly Arg Asn Arg Asp Leu

245 250 255

Arg Glu Met Leu Arg Thr Thr Ile Ala Asp Arg Tyr Tyr Arg Glu Thr

260 265 270

Ala Arg Leu Ala Arg Val Leu Phe Leu His Leu Tyr Leu Phe Leu Ser 275 280 285

Arg Glu Ile Leu Trp Ala Ala Tyr Ala Glu Gin Met Met Arg Pro Asp

290 295 300

Leu Phe Asp Gly Leu Cys Cys Asp Leu Glu Ser Trp Arg Gin Leu Ala 305 310 315 320 Cys Leu Phe Gin Pro Leu Met Phe Ile Asn Gly Ser Leu Thr Val Arg

325 330 335

Gly Val Pro Val Glu Ala Arg Arg Leu Arg Glu Leu Asn His Ile Arg

340 345 350

Glu His Leu Asn Leu Pro Leu Val Arg Ser Ala Ala Ala Glu Glu Pro 355 360 365

Gly Ala Pro Leu Thr Thr Pro Pro Val Leu Gin Gly Asn Gin Ala Arg

370 375 380

Ser Ser Gly Tyr Phe Met Leu Leu Ile Arg Ala Lys Leu Asp Ser Tyr 385 390 395 400 Ser Ser Val Ala Thr Ser Glu Gly Glu Ser Val Met Arg Glu His Ala

405 410 415

Tyr Ser Arg Gly Arg Thr Arg Asn Asn Tyr Gly Ser Thr Ile Glu Gly

420 425 430

Leu Leu Asp Leu Pro Asp Asp Asp Asp Ala Pro Ala Glu Ala Gly Leu 435 440 445

Val Ala Pro Arg Met Ser Phe Leu Ser Ala Gly Gin Arg Pro Arg Arg

450 455 460

Leu Ser Thr Thr Ala Pro Ile Thr Asp Val Ser Leu Gly Asp Glu Leu 465 470 475 480 Arg Leu Asp Gly Glu Glu Val Asp Met Thr Pro Ala Asp Ala Leu Asp

485 490 495

Asp Phe Asp Leu Glu Met Leu Gly Asp Val Glu Ser Pro Ser Pro Gly 500 505 510 Met Thr His Asp Pro Val Ser Tyr Gly Ala Leu Asp Val Asp Asp Phe

515 520 525

Glu Phe Glu Gin Met Phe Thr Asp Ala Met Gly Ile Asp Asp Phe Gly 530 535 540 Gly 545

(2) INFORMATION FOR SEQ ID NO: 302:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 490 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 302:

Met Asp Leu Leu Val Asp Asp Leu Phe Ala Asp Ala Asp Gly Val Ser 1 5 10 15

Pro Pro Pro Pro Arg Pro Ala Gly Gly Pro Lys Asn Thr Pro Ala Ala

20 25 30

Pro Pro Leu Tyr Ala Thr Gly Arg Leu Ser Gin Ala Gin Leu Met Pro 35 40 45

Ser Pro Pro Met Pro Val Pro Pro Ala Ala Leu Phe Asn Arg Leu Leu

50 55 60

Asp Asp Leu Gly Phe Ser Ala Gly Pro Ala Leu Cys Thr Met Leu Asp 65 70 75 80 Thr Trp Asn Glu Asp Leu Phe Ser Gly Phe Pro Thr Asn Ala Asp Met

85 90 95

Tyr Arg Glu Cys Lys Phe Leu Ser Thr Leu Pro Ser Asp Val Ile Asp

100 105 110

Trp Gly Asp Ala His Val Pro Glu Arg Ser Pro Ile Asp Ile Arg Ala 115 120 125

His Gly Asp Val Ala Phe Pro Thr Leu Pro Ala Thr Arg Asp Glu Leu

130 135 140

Pro Ser Tyr Tyr Glu Ala Met Ala Gin Phe Phe Arg Gly Glu Leu Arg 145 150 155 160 Ala Arg Glu Glu Ser Tyr Arg Thr Val Leu Ala Asn Phe Cys Ser Ala

165 170 175

Leu Tyr Arg Tyr Leu Arg Ala Ser Val Arg Gin Leu His Arg Gin Ala 180 185 190 His Met Arg Gly Arg Asn Arg Asp Leu Arg Glu Met Leu Arg Thr Thr

195 200 205

Ile Ala Asp Arg Tyr Tyr Arg Glu Thr Ala Arg Leu Ala Arg Val Leu

210 215 220 Phe Leu His Leu Tyr Leu Phe Leu Ser Arg Glu Ile Leu Trp Ala Ala

225 230 235 240

Tyr Ala Glu Gin Met Met Arg Pro Asp Leu Phe Asp Gly Leu Cys Cys

245 250 255

Asp Leu Glu Ser Trp Arg Gin Leu Ala Cys Leu Phe Gin Pro Leu Met 260 265 270

Phe Ile Asn Gly Ser Leu Thr Val Arg Gly Val Pro Val Glu Ala Arg

275 280 285

Arg Leu Arg Glu Leu Asn His Ile Arg Glu His Leu Asn Leu Pro Leu

290 295 300 Val Arg Ser Ala Ala Ala Glu Glu Pro Gly Ala Pro Leu Thr Thr Pro

305 310 315 320

Pro Val Leu Gin Gly Asn Gin Ala Arg Ser Ser Gly Tyr Phe Met Leu

325 330 335

Leu Ile Arg Ala Lys Leu Asp Ser Tyr Ser Ser Val Ala Thr Ser Glu 340 345 350

Gly Glu Ser Val Met Arg Glu His Ala Tyr Ser Arg Gly Arg Thr Arg

355 360 365

Asn Asn Tyr Gly Ser Thr He Glu Gly Leu Leu Asp Leu Pro Asp Asp

370 375 380 Asp Asp Ala Pro Ala Glu Ala Gly Leu Val Ala Pro Arg Met Ser Phe

385 390 395 400

Leu Ser Ala Gly Gin Arg Pro Arg Arg Leu Ser Thr Thr Ala Pro lie

405 410 415

Thr Asp Val Ser Leu Gly Asp Glu Leu Arg Leu Asp Gly Glu Glu Val 420 425 430

Asp Met Thr Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Glu Met Leu

435 440 445

Gly Asp Val Glu Ser Pro Ser Pro Gly Met Thr His Asp Pro Val Ser 450 455 460 Tyr Gly Ala Leu Asp Val Asp Asp Phe Glu Phe Glu Gin Met Phe Thr 465 470 475 480

Asp Ala Met Gly Ile Asp Asp Phe Gly Gly 485 490

(2) INFORMATION FOR SEQ ID NO: 303:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 552 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: peptide

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 303:

Met Arg Gly Gly Gly Arg Glu Met Ser Val Leu Gly Asp Ala Arg His 1 5 10 15

Pro Arg Arg Phe Pro Ser Arg Gly Pro Arg Pro Phe Ser Val Ala Gly

20 25 30

Pro Gly Ser Leu Pro Pro Ser Pro Pro Pro Gly Ala Arg Ala Arg Leu 35 40 45 He Arg Leu Ser Arg Ser Leu Phe Pro Asp Pro Thr Ala Pro Met Asp 50 55 60

Leu Leu Val Asp Asp Leu Phe Ala Asp Ala Asp Gly Val Ser Pro Pro 65 70 75 80

Pro Pro Arg Pro Ala Gly Gly Pro Lys Asn Thr Pro Ala Ala Pro Pro 85 90 95

Leu Tyr Ala Thr Gly Arg Leu Ser Gin Ala Gin Leu Met Pro Ser Pro

100 105 110

Pro Met Pro Val Pro Pro Ala Ala Leu Phe Asn Arg Leu Leu Asp Asp 115 120 125 Leu Gly Phe Ser Ala Gly Pro Ala Leu Cys Thr Met Leu Asp Thr Trp 130 135 140

Asn Glu Asp Leu Phe Ser Gly Phe Pro Thr Asn Ala Asp Met Tyr Arg 145 150 155 160

Glu Cys Lys Phe Leu Ser Thr Leu Pro Ser Asp Val Ile Asp Trp Gly 165 170 175

Asp Ala His Val Pro Glu Arg Ser Pro Ile Asp Ile Arg Ala His Gly

180 185 190

Asp Val Ala Phe Pro Thr Leu Pro Ala Thr Arg Asp Glu Leu Pro Ser 195 200 205 Tyr Tyr Glu Ala Met Ala Gin Phe Phe Arg Gly Glu Leu Arg Ala Arg 210 215 220

Glu Glu Ser Tyr Arg Thr Val Leu Ala Asn Phe Cys Ser Ala Leu Tyr 225 230 235 240

Arg Tyr Leu Arg Ala Ser Val Arg Gin Leu His Arg Gin Ala His Met 245 250 255

Arg Gly Arg Asn Arg Asp Leu Arg Glu Met Leu Arg Thr Thr Ile Ala

260 265 270

Asp Arg Tyr Tyr Arg Glu Thr Ala Arg Leu Ala Arg Val Leu Phe Leu 275 280 285

His Leu Tyr Leu Phe Leu Ser Arg Glu Ile Leu Trp Ala Ala Tyr Ala

290 295 300

Glu Gin Met Met Arg Pro Asp Leu Phe Asp Gly Leu Cys Cys Asp Leu 305 310 315 320

Glu Ser Trp Arg Gin Leu Ala Cys Leu Phe Gin Pro Leu Met Phe Ile

325 330 335

Asn Gly Ser Leu Thr Val Arg Gly Val Pro Val Glu Ala Arg Arg Leu 340 345 350 Arg Glu Leu Asn His Ile Arg Glu His Leu Asn Leu Pro Leu Val Arg 355 360 365

Ser Ala Ala Ala Glu Glu Pro Gly Ala Pro Leu Thr Thr Pro Pro Val

370 375 380

Leu Gin Gly Asn Gin Ala Arg Ser Ser Gly Tyr Phe Met Leu Leu Ile 385 390 395 400

Arg Ala Lys Leu Asp Ser Tyr Ser Ser Val Ala Thr Ser Glu Gly Glu

405 410 415

Ser Val Met Arg Glu His Ala Tyr Ser Arg Gly Arg Thr Arg Asn Asn 420 425 430 Tyr Gly Ser Thr Ile Glu Gly Leu Leu Asp Leu Pro Asp Asp Asp Asp 435 440 445

Ala Pro Ala Glu Ala Gly Leu Val Ala Pro Arg Met Ser Phe Leu Ser

450 455 460

Ala Gly Gin Arg Pro Arg Arg Leu Ser Thr Thr Ala Pro Ile Thr Asp 465 470 475 480

Val Ser Leu Gly Asp Glu Leu Arg Leu Asp Gly Glu Glu Val Asp Met

485 490 495

Thr Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Glu Met Leu Gly Asp 500 505 510 Val Glu Ser Pro Ser Pro Gly Met Thr His Asp Pro Val Ser Tyr Gly 515 520 525

Ala Leu Asp Val Asp Asp Phe Glu Phe Glu Gin Met Phe Thr Asp Ala

530 535 540

Met Gly Ile Asp Asp Phe Gly Gly 545 550

Claims

What is claimed is:

I . An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of:

(a) a polynucleotide having at least a 70% identity to a polynucleotide encoding a polypeptide comprising an amino acid sequence of Table 1, 2, 3 or 4;

(b) a polynucleotide having at least a 70% identity to a polynucleotide encoding a mature polypeptide expressed by the gene contained in the HSV-2 of deposited strain VR-2546 that was sequenced to obtain a polynucleotide sequence of Table 1, 2 or 3;

(c) a polynucleotide encoding a polypeptide comprising an amino acid sequence which is at least 70% identical to an amino acid sequence of Table 1, 2, 3 or 4;

(d) a polynucleotide which is complementary to the polynucleotide of (a), (b) or (c); and

(e) a polynucleotide comprising at least 15 sequential bases of the polynucleotide of (a), (b), (c) or (d).

2. The polynucleotide of Claim 1 wherein the polynucleotide is DNA.

3. The polynucleotide of Claim 1 wherein the polynucleotide is RNA.

4. The polynucleotide of Claim 2 comprising the nucleic acid sequence selected from the group consisting of the nucleic acid sequences set forth in Table 1, 2 and 3.

5. The polynucleotide of Claim 2 which encodes a polypeptide comprising an amino acid sequence sequence selected from the group consisting of the amino acid sequences set forth in Table 1, 2, 3 and 4.

6. A vector comprising the polynucleotide of Claim 1.

7. A host cell comprising the vector of Claim 6.

8. A process for producing a polypeptide comprising expressing in the host cell of Claim 7 a polypeptide encoded by said polynucleotide.

9. A process for producing a polypeptide or fragment thereof comprising culturing a host cell of Claim 7 under conditions sufficient for the production of said polypeptide or fragment.

10. A polypeptide comprising an amino acid sequence which is at least 70% identical to an amino acid sequence selected from the group consisting of the amino acid sequences or fragments thereof set forth in Table 1, 2, 3 and 4.

I I. A polypeptide comprising an amino acid sequence selected from the group consisting of the amino acid sequences or fragments thereof set forth in Table 1, 2, 3, and 4.

12. An antibody generated against the polypeptide of claim 10.

13. An antagonist or agonist of the activity or expression of the polypeptide of claim 10.

14. A method for the treatment or prevention of disease of an individual comprising administering to the individual a therapeutically effective amount of the polypeptide of claim 10.

15. A method for the treatment of an individual having medical need to inhibit a viral polypeptide comprising administering to the individual a therapeutically effective amount of the antagonist of Claim 13.

16. A process for diagnosing a disease related to expression or activity of the polypeptide of claim 10 in an individual comprising (a) determining a nucleic acid sequence encoding said polypeptide, and/or

(b) analyzing for the presence or amount of said polypeptide in a sample derived from the individual.

17. A method for identifying compounds which inhibit or activate the polypeptide of claim 10 comprising (a) contacting a composition comprising the polypeptide with the compound to be screened under conditions to permit interaction between the compound and the polypeptide to assess the interaction of a compound, such interaction being associated with a second component capable of providing a detectable signal in response to the interaction of the polypeptide with the compound; and (b) determining whether the compound activates or inhibits polypeptide by detecting the presence or absence of the signal generated from the interaction of the compound with the polypeptide.

18. A method for inducing an immunological response in a mammal which comprises inoculating the mammal with the polypeptide of Claim 10, or a variant thereof, adequate to produce antibody and or T cell immune response to protect said animal from disease.

19. A method of inducing immunological response in a mammal which comprises delivering a nucleic acid vector to direct expression of a polypeptide of Claim 10, or a variant thereof, for expressing said polypeptide in vivo in order to induce an immunological response to produce antibody and or T cell immune response to protect said animal from disease.

20. The isolated polynucleotide of claim 1 wherein said nucleotide is selected from the group consisting of:

(a) a polynucleotide having at least a 90% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of Table 1, 2, 3 or 4; (b) a polynucleotide having at least a 90% identity to a polynucleotide encoding the same mature polypeptide expressed by the gene contained in the HSV-2 of the deposited strain VR-2546that was sequenced to obtain a.poly nucleotide sequence of Table 1, 2 or 3;

(c) a polynucleotide encoding a polypeptide comprising an amino acid sequence which is at least 90% identical to the amino acid sequence of Table 1 , 2, 3 or 4;

(d) a polynucleotide which is complementary to the polynucleotide of (a), (b) or (c); and

(e) a polynucleotide comprising at least 15 sequential bases of the polynucleotide of (a), (b), (c) or (d).

21. The isolated polynucleotide of Claim 1 selected from the group consisting of

(a) a polynucleotide having at least a 95% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of Table 1, 2, 3 or 4;

(b) a polynucleotide having at least a 95% identity to a polynucleotide encoding the same mature polypeptide expressed by the gene contained in the HSV-2 of the deposited strain VR-2546 that was sequenced to obtain a polynucleotide sequence of Table 1 , 2 or 3;

(c) a polynucleotide encoding a polypeptide comprising an amino acid sequence which is at least 95% identical to the amino acid sequence of Table 1 , 2, 3 or 4;

(d) a polynucleotide which is complementary to the polynucleotide of (a), (b) or (c); and (e) a polynucleotide comprising at least 15 sequential bases of the polynucleotide of (a), (b), (c) or (d).

22. An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of:

(a) a polynucleotide having at least a 50% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of Table 1, 2, 3 or 4 and obtained from a prokaryotic species other than HSV-2;

(b) a polynucleotide encoding a polypeptide comprising an amino acid sequence which is at least 50% identical to the amino acid sequence of Table 1, 2, 3 or 4 and obtained from a prokaryotic species other than HSV-2; and (c) a polynucleotide which is complementary to the polynucleotide of (a) or (b).

23. An isolated polypeptide having one of the amino acid sequences given in Table 1, 2, 3 or 4.

24. An isolated nucleic acid encoding one of the amino acid sequences of Claim 1 and nucleic acid sequences capable of hybridizing therewith under stringent conditions.

25. A recombinant vector comprising the nucleic acid sequences of Claim 24 and host cells transformed or transfected therewith.

26. A method of identifying an antiviral compound comprising contacting candidate compounds with a polypeptide of Claim 10 and selecting those compounds capable of inhibiting the bioactivity of said polypeptide.

27. Antiviral compounds identified by the method of Claim 26.

28. An isolated polypeptide having an amino acid sequence or fragment thereof given in Table 1, 2, 3 or 4.

29. An isolated nucleic acid encoding one of the amino acid sequences of Claim 28 and nucleic acid sequences capable of hybridizing therewith under stringent conditions.

30. A method of identifying an antiviral compound comprising contacting candidate compounds with a polypeptide of Claim 28 and selecting those compounds capable of inhibiting the bioactivity of said polypeptide.