KR102039633B1 - A recombinant herpes simplex virus vector comprising GM-CSF gene - Google Patents

Abstract

The present invention relates to a vector for producing recombinant herpes simplex virus type 1 (HSV-1) and uses thereof. By using the vector according to one aspect, a portion of the ICP6 gene region of HSV-1 can be deleted and at the same time various foreign genes can be recombined. Thus, HSV-1 manipulation can be facilitated and HSV-1 specific for cancer cells or tumor cells can be produced.

Description

Simple recombinant herpes virus shuttle vector comprising GM-CSF gene {A recombinant herpes simplex virus vector comprising GM-CSF gene}

As a recombinant herpes simplex virus type 1 (HSV-1), it relates to a shuttle vector containing a GM-CSF gene.

In order to conquer cancer around the world, many studies have been conducted, such as the development of anticancer drugs, but no fundamental treatment has been made. To this end, a target-oriented therapeutic agent is used to specifically treat cancer cells, and by using a viral vector, it has the advantage of being able to develop a gene therapeutic agent through genetic manipulation of the virus itself.

In this regard, in 2001, researchers from the Calgary Medical School in Canada, Partick Lee, found that Herpes Simplex Virus type 1 (HSV-1) was caused by mutations in the oncogenic gene (Las) present in cancer cells. It has been reported that it causes a selective infection of, and through this, can kill cancer cells. Compared to other viral vectors, the herpes virus has the advantage of being able to insert a variety of genes because there is no limit on the size of the inserted gene. However, most of the currently developed anticancer HSV-1 has a limitation in that its therapeutic efficacy is low because viral replication is restricted as genes required for viral replication are lost.

In addition, since HSV-1 is a DNA virus with a size of 152 kb, it is not easy to manipulate the gene and it is technically difficult to mount a therapeutic gene. In general, in order to manufacture recombinant HSV-1 by manipulating the HSV-1 gene, most of the desired gene sites for insertion or substitution are amplified by PCR, but the PCR method is likely to cause mutations in the sequence to be substituted or inserted in the PCR process. In addition, when the GC ratio of the sequence is high, the PCR efficiency is low, and thus it is difficult to obtain sufficient PCR fragments to perform recombination. In addition, since HSV-1 has a very complex genetic structure compared to other viral vectors, a recombinant vector that can be prepared so that it cannot self-replicate is produced to eliminate the ability to generate lysosomes while maintaining the latent infection ability for use in clinical trials. It is difficult to make.

Therefore, there is a need for research on a method for easily recombining HSV-1, which causes selective infection for cancer.

The present invention relates to a system for easily recombining a gene of HSV-1 that causes selective infection for cancer, and an object thereof is to provide a recombinant vector, a recombinant HSV-1, and a method for producing the same.

One aspect provides a vector for HSV-1 recombination.

A vector according to an aspect of the present invention includes a nucleotide sequence in which some regions of the ICP6 (Infected-cell protein 6) gene derived from HSV-1 (Herpes Simplex Virus 1) have been deleted. In order to produce recombinant HSV-1, a vector structure in which some regions of the ICP6 gene derived from HSV-1 have been deleted has not yet been reported, so the vector according to an aspect of the present invention is a recombinant vector having a novel structure, and the vector There has been no report on the production of HSV-1 as a recombinant assassination wound using. Since some regions of the ICP6 gene derived from HSV-1 have been deleted, a foreign gene is inserted into the region in which ICP6 has been deleted, and the recombinant vector is transformed into HSV-1, so that between the ICP-6 regions of the genomic region of HSV-1 The foreign gene is efficiently inserted by homologous recombination. Therefore, compared to the conventional method for producing recombinant HSV-1 having low efficiency, it is possible to easily prepare recombinant HSV-1 with superior efficiency. In the present specification, "deletion" means removing a gene present on the genome. For example, a restriction enzyme can be used to remove a gene. The entire gene or part of the gene nucleotide sequence may be removed by a gene cloning method using a restriction enzyme. Expression of the functional protein of the gene does not occur or is inhibited by the deletion of the gene.

In the present specification, "substitution" means replacing a gene present in the genome with another gene. For example, a gene can be replaced using homologous recombination.

In the present specification, "homologous recombination" refers to what occurs between very similar long nucleotides. This is a necessary phenomenon when new 　DNA 　 molecules are introduced into the cell through several 　gene 　 exchange methods. Once the external 　DNA enters the bacterium, it is preserved in the cell in different forms depending on the 　DNA　 type. There are cases of plasmids that can be replicated independently and coexist with chromosomes, but in the case of DNA that does not have the ability to replicate themselves, it has no choice but to keep them inserted into the chromosome through genetic recombination. Homologous recombination takes place in order to be inserted into the chromosome in this way. In the present specification, a "vector" is a construct capable of expressing a protein of interest or RNA of interest in an appropriate host cell, and includes essential regulatory elements operably linked to express a gene insert. Refers to the genetic construct. The vector may preferably be a vector containing essential regulatory elements operably linked so that the gene insert is expressed, for example, a plasmid vector, a cozmid vector and a bacteriophage vector, an adenovirus vector, a retroviral vector and an adeno- Includes viral vectors such as associated viral vectors. Vectors that can be used as the vector include plasmids used in the art (e.g., pSP72, pSC101, pGV1106, pACYC177, ColE1, pKT230, pME290, pBR322, pUC8/9, pUC6, pBD9, pHC79, pIJ61, pLAFR1, pHV14 , pGEX series, pQE series, pBAD series, pET series and pUC19, etc.), phage (e.g., λgt4λB, λ-Charon, λΔz1 and M13, etc.) or virus (e.g. CMV, SV40, etc.) Can be. The vector may more preferably be a plasmid vector.

The vector may contain a promoter for gene expression. In the present specification, the "promoter" refers to a nucleic acid sequence that controls the expression of another nucleic acid sequence operably linked in an appropriate host cell, and "operably linked" herein refers to a nucleic acid to perform a general function. It refers to a functional linkage between the expression control sequence and the nucleic acid sequence encoding the protein or RNA of interest. For example, a promoter and a nucleic acid sequence encoding a protein or RNA can be operably linked to affect the expression of the coding sequence. The operative linkage of the promoter in the DNA construct or vector can be prepared using gene recombination techniques well known in the art, and site-specific DNA cleavage and linkage use enzymes generally known in the art. . In the case of using prokaryotic cells as a host, a strong promoter capable of promoting transcription (e.g., pLλ promoter, trp promoter, lac promoter, tac promoter, T5 promoter, T7 promoter, PBAD promoter, etc.), for initiation of translation It is common to include a ribosome binding site and a transcription/translation termination sequence. In the case of eukaryotic cells as a host, the origin of replication operating in eukaryotic cells included in the vector is the origin of replication f1, origin of replication SV40, origin of replication of pMB1, origin of replication of adeno, origin of replication of AAV, origin of replication of CMV and origin of replication of BBV, etc. Including, but not limited to. In addition, a promoter derived from the genome of a mammalian cell (e.g., metallotionine promoter) or a promoter derived from mammalian virus (e.g., adenovirus late promoter, vaccinia virus 7.5K promoter, SV40 promoter, The cytomegalovirus (CMV) promoter and the tk promoter of HSV) can be used and generally have a polyadenylation sequence as the transcription termination sequence.

The vector may further include an antibiotic resistant region or an origin of replication.

In the present specification, "total vector" refers to a vector having all the genes of HSV-1. Since it contains BAC (Bacterial artificial chromosome) and YAC (Yeast artificial chromosome), it is possible to propagate HSV-1 DNA or clone genes in a microbial system.

In the present specification, "shuttle vector" refers to a vector having some genes of HSV-1. The total vector and the shuttle vector can be homologously recombined by a common gene sequence.

In this specification, "Herpes simplex virus (Herpes Simplex Virus: HSV)" is herpes irregularities having a (Herpesviridae), viruses belonging to, herpes simplex virus type 1 (Herpes Simplex Virus type 1: HSV -1) and herpes simplex virus type 2 (Herpes Simplex Virus type 2: HSV-2). HSV-1 is also referred to as Human Herpes Virus type 1: HHV-1. The nucleic acid of HSV-1 is double-stranded linear DNA. Thus, the genome of HSV-1 may be composed of double-stranded linear DNA. If the genomic sequence of HSV-1 is a genomic sequence of a known HSV-1 strain, the kind is not limited. An exemplary sequence of the HSV-1 genome is NCBI GenBank Accession No. It is described in JQ673480.1. Unless otherwise disclosed herein, “HSV-1” is used interchangeably with “wild type HSV-1” and is distinguished from “recombinant HSV-1” according to one aspect.

In the present specification, "ICP6 (Infected-cell protein 6)" may refer to the UL39 gene derived from HSV-1. The nucleotide sequence of ICP6 may have a size of about 4.8 kb. Exemplary nucleotide sequence of the ICP6 gene is NCBI GenBank Accession No. It may be the 86,364 to 89,777 nucleotide sequence of the HSV-1 genomic sequence described in JQ673480.1. In one embodiment, the nucleotide included in the vector may be one in which some regions of the ICP6 gene have been deleted.

The size of the deleted partial region may be about 200 to 3000 nucleotides. If the size of some of the deleted regions is 200 nucleotides or less, the homologous recombination efficiency decreases upon transduction into HSV-1, which may lower the HSV-1 recombination efficiency.

The deleted partial region may be, for example, 87,000 to 90,000 th, more specifically 86,901 to 89,573 th sequence of the nucleotide sequence of SEQ ID NO: 1. Even if the sequence is deleted, the specificity of cancer tissue or tumor tissue of recombinant HSV-1 can be maintained.

The nucleotide sequence included in the vector may further include a partial nucleotide sequence of the UL38 (Unique Long 38) gene at the 3'end. For example, some nucleotide sequences of the UL38 (Unique Long 38) gene may include the 85,225 to 86,364 th sequence of the nucleotide sequence of SEQ ID NO: 1, but it does not affect the HSV-1 recombination function of the vector according to one aspect. If the sequence is not limited thereto.

The nucleotide sequence included in the vector may further include a partial nucleotide sequence of the UL40 or UL41 gene at the 5'end. For example, some of the nucleotide sequences of the UL40 or UL41 gene may include the 89,777 to 91,177 th sequence of the nucleotide sequence of SEQ ID NO: 1, but if a sequence does not affect the HSV-1 recombination function of the vector according to an aspect It is not limited thereto.

The sequence that may be further included may be a sequence that does not inhibit the function for achieving the purpose of the vector of one aspect, and for example, for convenience of vector construction, it may be selected as a sequence of a desired size by a person skilled in the art.

The vector may have a genetic map of FIG. 2.

Another aspect is the step of preparing a vector comprising a nucleotide sequence in which some regions of the ICP6 gene derived from HSV-1 are deleted; And transducing the vector into cells to obtain recombinant HSV-1.

In the above method, the vector may be a foreign gene additionally introduced into a partial region of the deleted ICP6 gene.

The step of obtaining the recombinant HSV-1 may be performed by transduction by homologous recombination occurring between the ICP6 gene of HSV-1 and the vector.

The recombinant HSV-1 is that the ICP6 gene region in the HSV-1 genome has been deleted and is recombined with a foreign gene, and the foreign gene may be homologously recombined with the ICP6 gene of the cell upon transduction. The method uses a vector containing a nucleotide in which some regions of the ICP6 gene derived from HSV-1 are deleted as a shuttle vector, and has characteristics similar to the ICP6 gene sequence included in the shuttle vector when the shuttle vector is introduced into a host cell. It is intended to insert ICP6 and foreign genes into the chromosome through homologous recombination.

The method of transducing the vector into cells may be performed through various methods known in the art. For example, microinjection (Capecchi, MR, Cell, 22:479 (1980); And Harland and Weintraub, J. Cell Biol. 101:1094-1099 (1985)), calcium phosphate precipitation (Graham, FL et al. ., Virology, 52:456 (1973); And Chen and Okayama, Mol. Cell. Biol. 7:2745-2752 (1987)), electroporation (Neumann, E. et al., EMBO J., 1: 841 (1982); And Tur-Kaspa et al., Mol. Cell Biol., 6:716-718 (1986)), liposome-mediated transfection (Wong, TK et al., Gene, 10:87 (1980)) ); Nicolau and Sene, Biochim.Biophys. Acta, 721:185-190 (1982); And Nicolau et al., Methods Enzymol., 149:157-176 (1987)), DEAE-dextran treatment (Gopal, Mol Cell Biol., 5:1188-1190 (1985)), and Gene Bombadment (Yang et al., Proc. Natl. Acad. Sci., 87:9568-9572 (1990)). Can be transfected.

In the present specification, the "foreign gene" may include all genes of origin different from HSV-1 of the present invention, genes that are heterogeneous to HSV-1 of the present invention, and genes that are heterogeneous to the host when introduced into an appropriate host. It is not limited as long as it is inserted into a vector according to an aspect and can be used to produce recombinant HSV-1 by transduction into HSV-1 by homologous recombination.

Examples of the foreign gene include a nucleic acid encoding a protein, a nucleic acid encoding an antisense RNA, a nucleic acid encoding a ribozyme, and the like. The origin of such foreign genes is not particularly limited, and examples thereof include microorganisms such as bacteria, yeasts, radioactive fungi, filamentous fungi, associa fungi, basidiomycetes, and the like; plant; insect; Animals, etc. may be mentioned, and may include genes artificially synthesized depending on the purpose, but is not limited thereto.

The foreign gene as used herein refers to a nucleotide sequence that is expressed in abnormal cells and exhibits a therapeutic effect. As the therapeutic gene of the present invention, any gene that has a therapeutic effect by acting on diseased cells (abnormal cells) can be used. The therapeutic gene may be for cancer treatment, but is not limited thereto.

Regarding the therapeutic gene for the treatment of cancer, for example, a drug sensitivity gene, apoptosis gene, a cell proliferation inhibitory gene, a cytotoxic gene, a tumor suppressor gene, an antigenic gene, an angiogenesis gene, a cytokine gene And the like may be included, but is not limited thereto.

The drug-sensitizing gene is a gene for an enzyme that converts a non-toxic prodrug into a toxic substance, and is also called a suicide gene because the transfected cell dies. That is, when a precursor that is not toxic to normal cells is systemically administered, the precursor is converted to a toxic metabolite only in cancer cells, thereby changing the sensitivity to drugs, thereby destroying cancer cells. Representatively, HSV-tk (Herpes simplex virus-thymidine kinase) gene, ganciclovir, E. coli cytosine deaminase (CD) gene, and 5-fluorocytosine (5-FC) ) Is possible.

The apoptotic gene refers to a nucleotide sequence that is expressed and induces programmed cell death. As apoptosis genes known to those skilled in the art, p53 gene, adenovirus E3-11.6K gene (derived from Ad2 and Ad5), adenovirus E3-10.5K (derived from Ad) gene, adenovirus E4 gene, p53 pathway gene or caspa A gene encoding the agent may be included.

The cytostatic gene refers to a nucleotide sequence that is expressed in a cell to stop the cell cycle during the cell cycle. Representatively, p21 gene, retinoblastoma gene, E2F-Rb fusion protein gene, genes encoding cyclin-dependent kinase inhibitors (e.g., p16, p15, p18 and p19), growth arrest specific homeobox (growth arrest specific) homeobox, GAX) genes (International Patent Application Publication Nos. WO 97/16459 and WO96/30385).

The cytotoxic gene refers to a nucleotide sequence that is expressed in cells and exhibits a toxic effect. For example, nucleotides encoding Pseudomonas exotoxin, lysine toxin, or diphtheria toxin

De-sequence genes.

The tumor suppressor gene refers to a nucleotide sequence that can be expressed in a target cell to suppress a tumor phenotype or induce apoptosis. Typically, tumor necrosis factor-α, TNF-α gene, p53 gene, APC gene, DPC-4/Smad4 gene, BRCA-1 gene, BRCA-2 gene, WT-1 gene, retinoblastoma gene (Lee et al., Nature, 329,642, 1987), MMAC-1 gene, adenomatous polyposis coil protein gene (Albertsen et al. U.S. Patent Publication No. US 5,783,666), defective colon tumor (DCC) Gene, MMSC-2 gene, NF-1 gene, nasopharyngeal tumor suppressor gene located on chromosome 3p21.3 (Cheng et al. Proc. Nat. Acad. Sci., 95,3042-3047, 1998), MTS1 gene, CDK4 gene, NF-1 gene, NF-2 gene, or VHL gene may be included.

The antigenic gene refers to a nucleotide sequence that is expressed in a target cell to produce a cell surface antigenic protein that can be recognized by the immune system. Examples of antigenic genes known to those skilled in the art may include a carcinoembryonic antigen (CEA) gene or a p53 gene (Levine, A., International Patent Application Publication No. WO 94/02167).

The anti-angiogenic gene refers to a nucleotide sequence that is expressed and releases an anti-angiogenic factor to the outside of the cell. Examples thereof may include angiostatin gene, an inhibitory factor gene of vascular endothelial growth factor (VEGF), or an endostatin gene.

유전자 또는 인터페론 γ 유전자 등이 포함될 수 있다. 상기 방법에 따르면, 크기가 커서 조작이 어려운 HSV-1을 쉽게 조작하여 상동 재조합을 통한 재조합 HSV-1을 제조할 수 있고, PCR 증폭을 통한 재조합에 비하여 돌연변이 발생 가능성이 없고 절차가 간편한 장점이 있다.The cytokine gene refers to a nucleotide sequence that is expressed in a cell to generate a cytokine. Typically, GM-CSF gene, interleukin (IL-1, IL-2, IL-4, IL-12, IL-10, IL-19, IL-20) gene, interferon α gene, interferon

Gene or interferon γ gene may be included. According to the above method, HSV-1, which is difficult to manipulate because of its large size, can be easily manipulated to produce recombinant HSV-1 through homologous recombination, and compared to recombination through PCR amplification, there is no possibility of mutation and the procedure is simple. .

Another aspect provides a recombinant HSV-1 prepared according to the above method.

The recombinant HSV-1 may exhibit cancer cell or tumor cell specificity. That is, the recombinant HSV-1 may be an oncolytic virus. The term “oncology virus” is used interchangeably with “cancer lysing virus” and “anti-cancer virus”. The oncogenic virus can activate immune cells by exposing antigens of cancer cells by specifically killing cancer cells or tumor cells. Therefore, the oncolytic virus itself can be used for anti-cancer purposes, and can also be used in combination with other anti-cancer agents to enhance the anti-cancer effect. In addition, it is possible to enhance the anticancer effect by inserting various therapeutic genes into an oncogenic virus vector.

Another aspect provides a pharmaceutical composition comprising the recombinant HSV-1.

The recombinant HSV-1 is as described above.

The pharmaceutical composition may be a pharmaceutical composition for anticancer.

The "cancer" is an aggressive characteristic in which cells divide and grow while ignoring normal growth limits, invasive properties that penetrate into surrounding tissues, and metastatic properties that spread to other areas inside and outside the body. It refers to diseases caused by cells having The cancer has the same meaning as a malignant tumor or a tumor, and may include a solid tumor and a blood born tumor. The type of cancer is not limited.

The pharmaceutical composition may be used in combination with an existing cancer treatment substance (eg, anticancer agent) to improve cancer treatment efficacy. The anticancer agent may be a metabolic antagonist, an alkylating agent, a topoisomerase antagonist, a microtubule antagonist, an anticancer antibiotic, a plant-derived alkaloid, an antibody anticancer agent or a molecular target anticancer agent, and more specifically, Taxol, Nitrogen Mustard, Imatinib, Oxaliplatin, Ritux Simab, Erlotinib, Trastuzumab, Gefitinib, Bortezomib, Sunitinib, Carboplatin, Sorafenib, Bevacizumab, Cisplatin, Cetuximab, Viscumalbum, Asparaginase, Tretinoin, Hydroxy Carbamide, Dasatinib, Estramustine, Gemtuzumab ozogamycin, Ibritumomab Tucetan, Heptaplatin, Methylaminolevulinic Acid, Amsacrine, Alemtuzumab, Procarbazine, Alprostadil, Nitric Acid Holmium chitosan, gemcitabine, doxyfluridine, pemetrexed, tegafur, capecitabine, gimeracil, oteracil, azacitidine, methotrexate, uracil, cytarabine, fluorouracil, fludarabine, Enocitabine, decitabine, mercaptopurine, thioguanine, cladribine, carmophor, raltitrexed, docetaxel, paclitaxel, irinotecan, belotecan, topotecan, vinorelbine, etoposide, vincristine, vinblastine , Teniposide, doxorubicin, darubicin, epirubicin, mitoxantrone, mitomycin, bleomycin, daunorubicin, dactinomycin, pyrarubicin, aclarubicin, peplomycin, temozolomide, Busulfan, ifosfamide, cyclophosphamide, melpharan, altrethmin, dacarbazine, thiotepa, nimustine, chlorambucil, mitrolactol, lomustine and carmustineyl, imatinib, gefitinib, Ertotinib, Tristuzumab, Rosiletinib, Necitumumab, Everolimus, Ramucirumab, Dacomitinib, Foretinib, Pembrolizumab, Ipilimumab, Nivolumab, Dabrafenib, Veliparib, Se It may be ritinib, carmustine, cyclophosphamide, ifosfamide, ixabepilone, melphalan, mercaptopurine, mitosantrone, or TS1, but is not limited thereto.

The composition may be administered simultaneously, separately, or sequentially in combination with an immune checkpoint inhibitor. The "immune checkpoint" is a generic term for proteins involved in inducing stimulation or suppression signals of an immune response on the surface of immune cells, and cancer cells are manipulated so that stimulation of the immune response and suppression of cancer cells accordingly through these immune checkpoints do not proceed properly. This avoids the surveillance network of the immune system, that is, neutralizes the anti-tumor immune response. The immune checkpoint inhibitors are PD-1 (programmed cell death-1), PD-L1 (programmed cell deathligand 1), PD-L2 (programmed cell death-ligand 2), CD27 (cluster of differentiation 27), and CD28 (cluster of differentiation 28), CD70 (cluster of differentiation 70), CD80 (cluster of differentiation 80; also known as B7-1), CD86 (cluster of differentiation 86; also known as B7-2), CD137 (cluster of differentiation 137), CD276 ( cluster of differentiation 276), KIRs (killer-cell immunoglobulin-like receptors), LAG3 (lymphocyte-activation gene 3), TNFRSF4 (tumor necrosis factor receptor superfamily, member 4; also known as CD134), GITR (glucocorticoid-induced TNFR-related). protein), GITRL (glucocorticoid-induced TNFR-related protein ligand), 4-1BB ligand (4-1BBL), and cytolytic T lymphocyte associated antign-4 (CTLA-4) antagonists, but limited thereto. It doesn't work.

The pharmaceutical composition may further include a pharmaceutically acceptable carrier or diluent. A pharmaceutically acceptable carrier or diluent may be known in the art. The carrier or diluent is lactose, dextrose, sucrose, sorbitol, mannitol, starch, gum acacia, calcium phosphate, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water (e.g. For example, saline and sterile water), syrup, methyl cellulose, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, mineral oil, Ringer's solution, buffer, maltodextrin solution, glycerol, ethanol, dextran, albumin , Or any combination thereof. The pharmaceutical composition may further include a lubricant, a wetting agent, a sweetening agent, a flavoring agent, an emulsifying agent, a suspending agent, or a preservative.

The pharmaceutical composition may be prepared in unit dosage form by formulation using a pharmaceutically acceptable carrier and/or excipient according to a method known to those skilled in the art, or may be prepared by incorporating it into a multi-dose container. In this case, the formulation may be in the form of a solution, suspension, syrup, or emulsion in an oil or aqueous solvent, or in the form of an extract, powder, powder, granule, tablet or capsule, and may additionally include a dispersant or a stabilizer. The aqueous solvent may include physiological saline or PBS. The pharmaceutical composition according to an embodiment may be formulated in an oral or parenteral dosage form, preferably a parenteral dosage form. In the case of intramuscular, intraperitoneal, subcutaneous and intravenous dosage forms, a sterile solution of the active ingredient is usually prepared, and a buffer capable of appropriately adjusting the pH of the solution may be included, and in the case of intravenous administration, it appears in the formulation. An tonicity agent may be included so that sex is imparted.

The dosage (effective amount) of the pharmaceutical composition is prescribed in various ways depending on factors such as formulation method, administration mode, patient's age, weight, sex, pathological condition, food, administration time, route of administration, excretion rate and response sensitivity. It can be, and those skilled in the art can appropriately adjust the dosage in consideration of these factors. Possible routes of administration may include parenteral (e.g., subcutaneous, intramuscular, intraarterial, intraperitoneal, intrathecal, or intravenous), topical (including transdermal), and injection, or insertion of implantable devices or materials. have. Examples of animals to be treated according to one embodiment include humans and mammals for other purposes, specifically humans, monkeys, mice, rats, rabbits, sheep, cows, dogs, horses, pigs, etc. Included. The composition may be used alone or in combination with auxiliary treatment methods such as surgical operation therapy. Chemotherapeutic agents that can be used with the composition include cisplatin, carboplatin carboplatin, procarbazine, mechlorethamine, cyclophosphamide, Ifosfamide, melphalan, chlorambucil, bisulfan, nitrosourea, dactinomycin, daunorubicin, doxorubicin ), bleomycin, plicomycin, mitomycin, etoposide, tamoxifen, taxol, transplatinum, 5-fluoro Uracil (5-fluorouracil), vincristin (vincristin), vinblastin (vinblastin), and may include methotrexate (methotrexate).

Radiation therapy that can be used with the composition is X-ray irradiation and γ-ray irradiation.

Another aspect provides a method of inhibiting cancer cell or tumor cell viability comprising administering to an individual an effective amount of the recombinant HSV-1 or a pharmaceutical composition comprising the recombinant HSV-1. The method may be a cancer treatment method.

The term "treatment" refers to, or includes alleviation, inhibition or prevention of a disease, disorder or condition, or one or more symptoms thereof, and "active ingredient" or "pharmaceutically effective amount" refers to a disease, disorder or condition, or It may mean any amount of a composition used in the practice of the invention provided herein sufficient to alleviate, inhibit or prevent progression of one or more symptoms.

The terms "administering", "introducing", and "implanting" are used interchangeably and one embodiment into a subject by a method or route that results in at least partial localization of a composition to a desired site according to one embodiment. It may mean the arrangement of the composition according to the example. It can be administered by any suitable route to deliver the active ingredient of the composition according to one embodiment to a desired location in a living individual. The survival period of the cells after administration to a subject may be several hours if short, for example from 24 hours to several days to several years if long.

The use of a vector according to one aspect can facilitate the manipulation of HSV-1 because a portion of the ICP6 gene site of HSV-1 is deleted and various foreign genes can be recombined, and HSV-1 specific for cancer cells or tumor cells can be used. Can be manufactured.

1 is a schematic diagram of wild-type HSV-1 (Wt-HSV-1).
Fig. 2 is a schematic diagram of a pSP72-ΔICP6 shuttle vector.
3 is a result of performing electrophoresis to verify the cloning of the pSP72-ΔICP6 plasmid.
4 is a schematic diagram of a pSP72-ΔICP6-mGM-CSF shuttle vector.
5 is a result of performing electrophoresis to verify whether the pSP72-ΔICP6-mGM-CSF shuttle vector is cloned.
6 is a diagram showing a homologous site for homologous recombination between the HSV-1-rpsL-neo total vector and the pSP72-ΔICP6-mGM-CSF vector.
7 is a schematic diagram of ΔICP6-GM-CFS HSV-1 prepared by homologous recombination between the HSV-1-rpsL-neo total vector and the pSP72-ΔICP6-mGM-CSF vector.
8 is a result of amplifying the GM-CFS gene by PCR in order to verify the recombinant HSV-1 (ΔICP6-GM-CFS HSV-1).
9 is a vero cell line (cell only), ΔICP6 virus, ΔICP6-GM-CFS virus after 48 hours treatment (ΔICP6-/GM 48 hours), and ΔICP6-GM-CFS virus 72 hours after treatment (ΔICP6-/ GM 72hr) is a graph showing the results of confirming the expression of GM-CFS in each cell by ELISA.

It will be described in more detail through the following examples. However, these examples are for illustrative purposes only and the scope of the present invention is not limited to these examples.

Example One. HSV -1 origin ICP6 Construction of a recombinant vector containing a sequence in which a part of the gene has been deleted

A recombinant vector including a sequence in which a portion of the HSV-1 derived ICP6 gene was deleted was constructed and verified.

1 is a schematic diagram of wild-type HSV-1 (Wt-HSV-1).

Wild-type HSV-1 is surrounded by a terminal repeat (TR) region on both sides _{and is divided into a U L} (unique long) region and a U _S (unique short) region by an internal repeat (IR) region. Wild-type HSV-1 has a total of three origins (ori sites), one at the U _L position (L) _{and two at the U S} position (S). ICP6 is a gene having a size of 3414 bp from the 86,364 th sequence to the 89,777 th sequence of HSV-1.

First, from the genomic sequence of wild-type HSV-1, using restriction enzymes SalI and EcoRV, the 89,574 to 91,177th nucleotide of the HSV-1 genomic region was cut to make a 1603 bp fragment (ICP6 R) blunt end, followed by restriction enzymes. The gene was cloned into pSP72 vector, which was cleaved with ClaI and BglII to make blunt ends, to make pSP72-ICP6-R.

Next, from the genomic sequence of wild-type HSV-1, the 85,225 to 86,900 nucleotides of the HSV-1 genomic region were cut using restriction enzymes NheI and BamHI to obtain a 1675 bp fragment (ICP6 L). The pSP72-ICP6-R was gene cloned into restriction enzymes XbaI and BamHI sites to produce a pSP72-ΔICP6 shuttle vector (pSP72-ΔICP6 Shuttle vector).

Nucleotides 89,574 to 91,177 in the wild-type HSV-1 genomic sequence correspond to a region including a part of the ICP6 gene and a part of the UL36 gene. The nucleotides 85,225 to 86,900 in the wild-type HSV-1 genomic sequence correspond to a region including a portion of the ICP6 gene and a portion of the UL40 and UL41 genes.

Fig. 2 is a schematic diagram of a pSP72-ΔICP6 shuttle vector.

To verify cloning, the pSP72-ΔICP6 shuttle vector was treated with restriction enzymes XhoI and SacI, respectively, and electrophoresis was performed to confirm the band.

3 is a result of performing electrophoresis to verify the cloning of the pSP72-ΔICP6 plasmid.

As shown in Figure 3, in the case of the control (uncut) not treated with the restriction enzyme, pSP72 itself showed a band of 2462bp size, and the pSP72-ΔICP6 plasmid showed a size of 5727bp. By the restriction enzyme XhoI treatment, pSP72 showed a band of 2462 bp, and the pSP72-ΔICP6 plasmid showed a band of 1141, 4586 bp, whereas the restriction enzyme SacI treatment showed that pSP72 had a band of 2462 bp, and the pSP72-ΔICP6 plasmid was 519, 1197, 4011 bp. Showed the band of. Therefore, it was verified that pSP72-ΔICP6 cloning was successfully performed.

Experimental example One. Example Insertion of a foreign gene into the vector of 1

In the vector of Example 1, a foreign gene was inserted into the region in which ICP6 was deleted, and the recombinant vector was transformed into HSV-1, whereby the foreign gene was homologously recombined between the ICP-6 regions of the genomic region of HSV-1. In order to confirm whether it can be efficiently inserted to produce recombinant HSV-1, the experiment was performed as follows. GM-CSF, a therapeutic gene, was used as a foreign gene. This therapeutic gene is exemplary, and the same effect can be obtained by inserting any foreign gene.

First, in order to insert the GM-CSF gene into the pSP72-ΔICP6 vector prepared in Example 1, the GM-CSF expression cassette plasmid (pVAX1-GM-CSF) was cut with MluI and NotI according to a known method, and then to a blunt end. The resulting fragment was gene cloned into the blunt-terminated BamHI site of the pSP72-ΔICP6-mIL12 shuttle vector, thereby constructing a pSP72-ΔICP6-mGM-CSF shuttle vector. It was confirmed with the restriction enzymes EcoRI and EcoRV.

4 is a schematic diagram of a pSP72-ΔICP6-mGM-CSF shuttle vector.

5 is a result of performing electrophoresis to verify whether the pSP72-ΔICP6-mGM-CSF shuttle vector is cloned.

As shown in Figure 5, in the case of the control (uncut) not treated with the restriction enzyme, pSP72-ΔICP6 showed a band of 5727bp size, and pSP72-ΔICP6-mGM-CSF showed a size of 7059bp. By the restriction enzyme EcoRV treatment, pSP72-ΔICP6 showed a band of 5725 bp, pSP72-ΔICP6-mGM-CSF showed a band of 1857 and 5202 bp, whereas pSP72-ΔICP6 showed a band of 5727 bp and pSP72-ΔICP6 by the restriction enzyme EcoRV treatment. -mGM-CSF showed bands of 589 and 6470 bp. Therefore, it was verified that the cloning of the pSP72-ΔICP6-mGM-CSF vector was successfully performed, and the pSP72- of the present invention was used to prepare a pSP72-ΔICP6-mGM-CSF vector that can be used as a shuttle vector for the production of recombinant HSV-1. It was confirmed that the ΔICP6 shuttle vector can be utilized.

Experimental example 2. Recombination HSV -1 manufacturing

Through Experimental Example 1, it was confirmed that a foreign gene could be inserted into the region in which ICP6 was deleted in the vector of Example 1, and HSV-1 was transformed by transducing the recombinant vector into HSV-1 to transform HSV-1. In order to confirm whether a foreign gene can be efficiently inserted between the ICP6 regions of the genomic regions by homologous recombination to produce recombinant HSV-1, an experiment was conducted as follows. GM-CSF, a therapeutic gene, was used as a foreign gene.

First, homologous recombination was induced by transforming the total vector expressing rps-neo and the pSP72-ΔICP6-mGM-CSF vector into DH10b E. coli in the ICP6 site of HSV-1-rpsL-neo HSV-1.

6 is a diagram showing a homologous site for homologous recombination between the HSV-1-rpsL-neo total vector and the pSP72-ΔICP6-mGM-CSF vector. The total vector of HSV-1 contains all of the HSV-1 gene and encodes the rpsL-neo gene in the ICP6 gene site. In the 85,225 to 86,900 regions of the total vector, ICP6 L of the ΔICP6-mGM-CSF shuttle vector is homologous to each other, and the ICP6 R of the shuttle vector from 89,574 to 911,777 regions of the total vector is homologous to each other, and recombination occurs in this region.

The ΔICP6-GM-CFS HSV-1 virus is produced by homologous recombination of the two vectors.

7 is a schematic diagram of ΔICP6-GM-CFS HSV-1 prepared by homologous recombination between HSV-1-rpsL-neo total vector and pSP72-ΔICP6-mGM-CSF vector.

In order to confirm whether the recombinant HSV-1 (ΔICP6-GM-CFS HSV-1) prepared as described above was prepared as intended, the GM-CFS gene was amplified through PCR. Each primer was used as a primer pair (Primer 1: ATG TTG TCG TCG CCG, Primer 2: GTG GCA TTC GGG GGA AC) and Master mix (K1081 / Thermo Scientific) containing 100 pmol/µl of primer, and PCR conditions were Denaturation. 95°C / 30s; Annealing 58° C. / 30s; Extension was set to 72°C/1min.

8 is a result of amplifying the GM-CFS gene by PCR in order to verify the recombinant HSV-1 (ΔICP6-GM-CFS HSV-1). The primer pairs for PCR are as follows.

ICP6 L/S primer 5'- GTG GCA TTC GGG GGA AC-3' ICP6 R / AS primer 5'- ATG TTG TCG TCG CCG CCA-3'

As shown in FIG. 8, since a 1715bpbp band was identified in the ΔICP6-GM-CFS of lane 4, it was verified that GM-CFS was inserted by homologous recombination.

Additionally, in order to confirm the expression of GM-CFS in the recombinant ΔICP6-GM-CFS HSV-1, ELISA was performed by a method known in the art. Specifically, ΔICP6-GM-CFS HSV-1 produced in vero cell line was treated with 5 MOI, and after 48 and 72 hours, the medium was collected and GM-CFS was used with a GM-CFS ELISA kit (MGMo0 / R&D systme / USA). The expression of was confirmed.

9 is a vero cell line (cell only), ΔICP6 virus, ΔICP6-GM-CFS virus after 48 hours treatment (ΔICP6-/GM 48 hours), and ΔICP6-GM-CFS virus 72 hours after treatment (ΔICP6-/ GM 72hr) is a graph showing the results of confirming the expression of GM-CFS in each cell by ELISA.

As shown in Fig. 9, it was confirmed that ΔICP6-GM-CFS HSV-1 stably expresses the GM-CFS protein.

Therefore, using the pSP72-ΔICP6 shuttle vector according to an aspect, recombinant HSV-1 can be produced by easily inserting a desired foreign gene through homologous recombination to the ICP6 gene on the genome of HSV-1.

SEQUENCE LISTING <110> SUNGKWANG MEDICAL FOUNDATION <120> A vector for preparing recombinant herpes simplex virus <130> pn122410 <160> 3 <170> PatentIn version 3.2 <210> 1 <211> 152011 <212> DNA <213> HSV-1 <400> 1 gcagcccggg ccccccgcgg gcgcgcgcgc gcgcaaaaaa ggcgggcggc ggtccgggcg 60 gcgtgcgcgc gcgcggcggg cgtggggggc ggggccgcgg gagcggggga ggagcggggg 120 aggagcgggg ggaggagcgg ggggaggagc ggggggagga gcggggggag gagcgggggg 180 aggagcgggg ggaggagcgg ggggaggagc ggggggagga gcggggggag gagcgggggg 240 aggagcgggg ggaggagcgg ggggaggagc ggggggagga gcggggggag gagcgggggg 300 aggagcgggg gaggagcggc cagaccccgg aaacgggccc cccccaaaac acaccccccg 360 ggggtcgcgc gcggcccttt aaaggcgggc ggcgggcagc ccgggccccc cgcggccgag 420 actagcgagt tagacaggca agcactactc gcctctgcac gcacatgctt gcctgtcaaa 480 ctctaccacc ccggcacgct ctctgtctcc atggcccgcc gccgccatcg cggcccccgc 540 cgcccccggc cgcccgggcc cacgggcgcg gtcccaaccg cacagtccca ggtaacctcc 600 acgcccaact cggaacccgt ggtcaggagc gcgcccgcgg ccgccccgcc gccgcccccc 660 gccagtgggc ccccgccttc ttgttcgctg ctgctgcgcc agtggctcca cgttcccgag 720 tccgcgtccg acgacgacga cgacgactgg ccggacagcc ccccgcccga gccggcgcca 780 gaggcccggc ccaccgccgc cgccccccgc ccccggtccc caccgcccgg cgcgggcccg 840 gggggcgggg ctaacccctc ccaccccccc tcacgcccct tccgccttcc gccgcgcctc 900 gccctccgcc tgcgcgtcac cgcagagcac ctggcgcgcc tgcgcctgcg acgcgcgggc 960 ggggaggggg cgccgaagcc ccccgcgacc cccgcgaccc ccgcgacccc cacgcgggtg 1020 cgcttctcgc cccacgtccg ggtgcgccac ctggtggtct gggcctcggc cgcccgcctg 1080 gcgcgccgcg gctcgtgggc ccgcgagcgg gccgaccggg ctcggttccg gcgccgggtg 1140 gcggaggccg aggcggtcat cgggccgtgc ctggggcccg aggcccgtgc ccgggccctg 1200 gcccgcggag ccggcccggc gaactcggtc taacgttaca cccgaggcgg cctgggtctt 1260 ccgcggagct cccgggagct ccgcaccaag ccgctctccg gagagacgat ggcaggagcc 1320 gcgcatatat acgcttggag ccggcccgcc cccgaggcgg gcccgccctc ggagggcggg 1380 actggccaat cggcggccgc cagcgcggcg gggcccggcc aaccagcgtc cgccgagtcg 1440 tcggggcccg gcccactggg cggtaactcc cgcccagtgg gccgggccgc ccacttcccg 1500 gtatggtaat taaaaacttg cagaggcctt gttccgcttc ccggtatggt aattagaaac 1560 tcattaatgg gcggccccgg ccgcccttcc cgcttccggc aattcccgcg gcccttaatg 1620 ggcaaccccg gtattccccg cctcccgcgc cgcgcgtaac cactcccctg gggttccggg 1680 ttatgttaat tgcttttttg gcggaacaca cggcccctcg cgcattggcc cgcgggtcgc 1740 tcaatgaacc cgcattggtc ccctggggtt ccgggtatgg taatgagttt cttcgggaag 1800 gcgggaagcc ccggggcacc gacgcaggcc aagcccctgt tgcgtcggcg ggaggggcat 1860 gctaatgggg ttctttgggg gacaccgggt tggtccccca aatcgggggc cgggccgtgc 1920 atgctaatga tattctttgg gggcgccggg ttggtccccg gggacggggc cgccccgcgg 1980 tgggcctgcc tcccctggga cgcgcggcca ttgggggaat cgtcactgcc gcccctttgg 2040 ggaggggaaa ggcgtggggt ataagttagc cctggcccga cggtctggtc gcatttgcac 2100 ctcggcactc ggagcgagac gcagcagcca ggcagactcg ggccgccccc tctccgcatc 2160 accacagaag ccccgcctac gttgcgaccc ccagggaccc tccgtcagcg accctccagc 2220 cgcatacgac ccccatggag ccccgccccg gagcgagtac ccgccggcct gagggccgcc 2280 cccagcgcga ggtgaggggc cgggcgccat gtctggggcg ccatgttggg gggcgccatg 2340 ttggggggcg ccatgttggg ggacccccga cccttacact ggaaccggcc gccatgttgg 2400 gggaccccca ctcatacacg ggagccgggc gccatgttgg ggcgccatgt tagggggcgt 2460 ggaaccccgt gacactatat atacagggac cgggggcgcc atgttagggg gcgcggaacc 2520 ccctgaccct atatatacag ggaccggggt cgccctgtta ggggtcgcca tgtgaccccc 2580 tgactttata tatacagacc cccaacacct acacatggcc cctttgactc agacgcaggg 2640 cccggggtcg ccgtgggacc cccctgactc atacacagag acacgccccc acaacaaaca 2700 cacagggacc ggggtcgccg tgttaggggg cgtggtcccc actgactcat acgcagggcc 2760 cccttactca cacgcatcta ggggggtggg gaggagccgc ccgccatatt tgggggacgc 2820 cgtgggaccc ccgactccgg tgcgtctgga gggcgggaga agagggaaga agaggggtcg 2880 ggatccaaag gacggaccca gaccaccttt ggttgcagac ccctttctcc cccctcttcc 2940 gaggccagca ggggggcagg actttgtgag gcgggggggg agggggaact cgtgggcgct 3000 gattgacgcg ggaaatcccc ccattcttac ccgccccccc ttttttcccc tcagcccgcc 3060 ccggatgtct gggtgtttcc ctgcgaccga gacctgccgg acagcagcga ctcggaggcg 3120 gagaccgaag tgggggggcg gggggacgcc gaccaccatg acgacgactc cgcctccgag 3180 gcggacagca cggacacgga actgttcgag acggggctgc tggggccgca gggcgtggat 3240 gggggggcgg tctcgggggg gagccccccc cgcgaggaag accccggcag ttgcgggggc 3300 gccccccctc gagaggacgg ggggagcgac gagggcgacg tgtgcgccgt gtgcacggat 3360 gagatcgcgc cccacctgcg ctgcgacacc ttcccgtgca tgcaccgctt ctgcatcccg 3420 tgcatgaaaa cctggatgca attgcgcaac acctgcccgc tgtgcaacgc caagctggtg 3480 tacctgatag tgggcgtgac gcccagcggg tcgttcagca ccatcccgat cgtgaacgac 3540 ccccagaccc gcatggaggc cgaggaggcc gtcagggcgg gcacggccgt ggactttatc 3600 tggacgggca atcagcggtt cgccccgcgg tacctgaccc tgggggggca cacggtgagg 3660 gccctgtcgc ccacccaccc tgagcccacc acggacgagg atgacgacga cctggacgac 3720 ggtgaggcgg gggggcggcg aggaccctgg gggaggagga ggaggggggg gggagggagg 3780 aataggcggg cgggcgggcg aggaaagggc gggccgggga gggggcgtaa cctgatcgcg 3840 ccccccgttg tctcttgcag cagactacgt accgcccgcc ccccgccgga cgccccgcgc 3900 ccccccacgc agaggcgccg ccgcgccccc cgtgacgggc ggggcgtctc acgcagcccc 3960 ccagccggcc gcggctcgga cagcgccccc ctcggcgccc atcgggccac acggcagcag 4020 taacactaac accaccacca acagcagcgg cggcggcggc tcccgccagt cgcgagccgc 4080 ggtgccgcgg ggggcgtctg gcccctccgg gggggttggg gttgttgaag cggaggcggg 4140 gcggccgagg ggccggacgg gcccccttgt caacagaccc gccccccttg caaacaacag 4200 agaccccata gtgatcagcg actccccccc ggcctctccc cacaggcccc ccgcggcgcc 4260 catgccaggc tccgcccccc gccccggtcc ccccgcgtcc gcggccgcgt cgggccccgc 4320 gcgcccccgc gcggccgtgg ccccgtgtgt gcgggcgccg cctccggggc ccggcccccg 4380 cgccccggcc cccggggcgg agccggccgc ccgccccgcg gacgcgcgcc gtgtgcccca 4440 gtcgcactcg tccctggctc aggccgcgaa ccaagaacag agtctgtgcc gggcgcgtgc 4500 gacggtggcg cgcggctcgg gggggccggg cgtggagggt ggacacgggc cctcccgcgg 4560 cgccgccccc tccggcgccg ccccctccgg cgcccccccg ctcccctccg ccgcctctgt 4620 cgagcaggag gcggcggtgc gtccgaggaa gaggcgcggg tcgggccagg aaaacccctc 4680 cccccagtcc acgcgtcccc ccctcgcgcc ggcaggggcc aagagggcgg cgacgcaccc 4740 cccctccgac tcagggccgg gggggcgcgg ccagggaggg cccgggaccc ccctgacgtc 4800 ctcggcggcc tccgcctctt cctcctccgc ctcttcctcc tcggccccga ctcccgcggg 4860 ggccacctct tccgccaccg gggccgcgtc ctcctccgct tccgcctcct cgggcggggc 4920 cgtcggtgcc ctgggaggga gacaagagga aacctccctc ggcccccgcg ctgcttctgg 4980 gccgcggggg ccgaggaagt gtgcccggaa gacgcgccac gcggagactt ccggggccgt 5040 ccccgcgggc ggcctcacgc gctacctgcc catctcgggg gtctctagcg tggtcgccct 5100 gtcgccttac gtgaacaaga cgatcacggg ggactgcctg cccatcctgg acatggagac 5160 ggggaacatc ggggcgtacg tggtcctggt ggaccagacg ggaaacatgg cgacccggct 5220 gcgggccgcg gtccccggct ggagccgccg caccctgctc cccgagaccg cgggtaacca 5280 cgtgacgccc cccgagtacc cgacggcccc cgcgtcggag tggaacagcc tctggatgac 5340 ccccgtgggg aacatgctgt tcgaccaggg caccctagtg ggcgccctgg acttccgcag 5400 cctgcggtct cggcacccgt ggtccgggga gcagggggcg tcgacccggg acgagggaaa 5460 acaataaggg acgcccccgt gtttgtgggg aggggggggt cgggcgctgg gtggtctctg 5520 gccgcgccca ctacaccagc caatccgtgt cggggaggtg gaaagtgaaa gacacgggca 5580 ccacacacca gcgggtcttt tgtgttggcc ctaataaaaa aaactcaggg gatttttgct 5640 gtctgttggg aaataaaggt ttacttttgt atcttttccc tgtctgtgtt ggatgtatcg 5700 cgggggtgcg tgggagtggg ggtgcgtggg agtgggggtg cgtgggagtg ggggtgcgtg 5760 ggagtggggg tgcgtgggag tgggggtgcg tgggagtggg ggtgcgtggg agtgggggtg 5820 cgtgggagtg ggggtgcgtg ggagtggggg tgccatgttg ggcaggctct ggtgttaacc 5880 acagagccgc ggcccgggct gcctgaccac cgatccccga aagcatcctg ccactggcat 5940 ggagccagaa ccacagtggg ttgggtgtgg gtgttaagtt tccgcgagcg cctgcccgcc 6000 cggactgacc tggcctctgg ccgccacaaa gggcgggggg gggggttaac tacactatag 6060 ggcaacaaag gatgggaggg gtagcggggc gggacggggc gcccaaaagg gggtcggcca 6120 caccacagac gtgggtgttg gggggtgggg cggaggggtg gggggggaga cagaaacagg 6180 aacatagtta gaaaacaaga atgcggtgca gccagagaat cacaggagac gaggggatgg 6240 gcgtgttggt taccaaccca cacccaggca tgctcggtgg tatgaaggag ggggggcggt 6300 gtttcttaga gaccgccggg ggacgtgggg ttggtgtgca aaggcacgcg cacccgcgcc 6360 ggccaggtgg gccggtaccc catccccccc tcccccgacc cttcccaccc ccgcgtgcca 6420 gagatcaccc cggtcccccg gcacccgcca ctcctccata tcctcgcttt aggaacaact 6480 ttaggggggg gtacacacgc gccgtgcatt tccttccaca ccccccccct cccccgcact 6540 cccccccccc aggcagtaag acccaagcat agagagccag gcacaaaaac acaggcgggg 6600 tgggacacat gccttcttgg agtacgtggg tcattggcgt ggggggttac agcgacaccg 6660 gccgaccccc tggcggtctt ccagccggcc cttagataag ggggcagttg gtggtcggac 6720 gggtaagtaa cagagtctaa ctaagggtgg gaggggggga aaataacggg ctggtgtgct 6780 gtaacacgag cccacccgcg agtggcgtgg ccgaccttag cctctggggc gccccctgtc 6840 gtttgggtcc ccccccctct attggggaga agcaggtgtc taacctacct ggaaacgcgg 6900 cgtctttgtt gaacgacacc ggggcgccct cgacgagtgg gataacgggg gaggaaggga 6960 gggaggaggg tactgggggt gaaggggggg ggggagaagc gagaacagga aaggcgacgg 7020 agcccggcag aacaccgagg aaaaaaaaac cacagcgcat gcgccgggcc gttgtggggc 7080 cccgggccgg ggccccttgg gtccgccggg gccccgggcc gggccgccac gggggccggc 7140 cgttggcggt aaccccgagt gttcatctca ggccccgggc cgggaacccg gaaaagcctc 7200 cggggggcct ttttcgcgtc gcgtgccggc gagcgggtcc ggacggggcc cggaccgccg 7260 cggtcggggg cccctcgtcc cgggccgtac gcggccttcg ccccgtgagg ggacagacga 7320 acgaaacatt ccggcgacgg aacgaaaaac accccagacg ggttaaagaa acagaaaccg 7380 caacccccac cacccccgaa acggggaaaa cgaaaaaaca gaccagcggc cggccggcgc 7440 ttagggggag gatgtcgccg acgccccttg gccgccccgg ctgcaggggg gcccggagag 7500 ccgcggcacc cggacgcgcc cggaaagtct ttcgcaccac cggcgatcgg cacggccgcg 7560 cccccgcttt tataaaggct cagatgacgc agcaaaaaca ggccacagca ccacatgggt 7620 aggtgatgta attttatttt cctcgtctgc ggcctaatgg atttccgggc gcggtgcccc 7680 tgtctgcaga gcacttaacg gattgatatc tcgcgggcac gcgcgccctt aatggaccgg 7740 cgcggggcgg ggggccggat acccacacgg gcgggggggg gtgtcgcggg ccgtctgctg 7800 gcccgcggcc acataaacaa tgactcgggg cctttctgcc tctgccgctt gtgtgtgcgc 7860 gcgccggctc tgcggtgtcg gcggcggcgg cggcggtggc cgccgtgttc ggtctcggta 7920 gccggccggc gggtggactc gcggggggcc ggagggtgga aggcaggggg gtgtaggatg 7980 ggtatcagga cttccacttc ccgtccttcc atcccccgtt cccctcggtt gttcctcgcc 8040 tcccccaaca ccccgccgct ttccgttggg gttgttattg ttgtcgggat cgtgcgggcc 8100 gggggtcgcc ggggcagggg cgggggcgtg ggcgggggtg ctcgtcgatc gaccgggctc 8160 agtgggggcg tggggtgggt gggagaaggc gaggagactg gggtgggggt gtcggtgggt 8220 ggttgttttt tgtggttgtt ttttgtgtct gtttccgtcc cccgtcaccc ccctccctcc 8280 gtcccctccg tccccccgtc gcgggtgttt gtgtttgttt attccgacat cggtttattt 8340 aaaataaaca cagccgttct gcgtgtctgt tcttgcgtgt ggctgggggc ttatatgtgg 8400 ggtcccgggg gcgggatggg gtttagcggc ggggggcggc gcgccggacg gggcgctgga 8460 gataacggcc cccggggaac gggggaccgg ggctgggtat cccgaggtgg gtgggtgggc 8520 ggcggtggcc gggccgggcc gggccgggcc gggtgggcgg ggtttggaaa aacgaggagg 8580 aggaggagaa ggcggggggg gagacggggg gaaagcaagg acacggcccg gggggtggga 8640 gcgcgggccg ggccgctcgt aagagccgcg acccggccgc cggggagcgt tgtcgccgtc 8700 ggtctgccgg cccccgtccc tccctttttt gaccaaccag cgccctcccc cccaccacca 8760 ttcctactac caccaccacc accaccccca ccaccgacac ctcccgcgca cccccgccca 8820 catcccccca ccccgcacca cgagcacggg gtgggggtag caggggatca aaggggggca 8880 aagccggcgg ggcggttcgg gggggcggga gaccgagtag gcccgcccat acgcggcccc 8940 tcccggcagc cacgcccccc agcgtcgggt gtcacgggga aagagcaggg gagagggggg 9000 gagaggggag agggggggag aggggagagg gggggagagg ggagaggggg ggagagggga 9060 gaggggggga gaggggagag ggggggagag gggagagggg gggagagggg agaggggggg 9120 agaggggaga gggggggaga ggggagaggg ggggagaggg ggtatataaa ccaacgaaaa 9180 gcgcgggaac ggggatacgg ggcttgtgtg gcacgacgtc gtggttgtgt tactgggcaa 9240 acacttgggg actgtaggtt tctgtgggtg ccgaccctag gcgctatggg gattttgggt 9300 tgggtcgggc ttattgccgt tggggttttg tgtgtgcggg ggggcttgtc ttcaaccgaa 9360 tatgttattc ggagtcgggt ggctcgagag gtgggggata tattaaaggt gccttgtgtg 9420 ccgctcccgt ctgacgatct tgattggcgt tacgagaccc cctcggctat aaactatgct 9480 ttgatagacg gtatattttt gcgttatcac tgtcccggat tggacacggt cttgtgggat 9540 aggcatgccc agaaggcata ttgggttaac ccctttttat ttgtggcggg ttttctggag 9600 gacttgagtc accccgcgtt tcctgccaac acccaggaaa cagaaacgcg cttggccctt 9660 tataaagaga tacgccaggc gctggacagt cgcaagcagg ccgccagcca cacacctgtg 9720 aaggctgggt gtgtgaactt tgactattcg cgcacccgcc gctgtgtagg gcgacaggat 9780 ttgggaccta ccaacggaac gtctggacgg accccggttc tgccgccgga cgatgaagcg 9840 ggcctgcaac cgaagcccct caccacgccg ccgcccatca tcgccacgtc ggaccccacc 9900 ccgcgacggg acgccgccac aaaaagcaga cgccgacgac cccactcccg gcgcctctaa 9960 cgatgcctcg acggaaaccc gtccgggttc ggggggcgaa ccggccgcct gtcgctcgtc 10020 agggccggcg ggcgctcctc gccgccctag aggctgtccc gctggtgtga cgttttcctc 10080 gtccgcgccc cccgaccctc ccatggattt aacaaacggg ggggtgtcgc ctgcggcgac 10140 ctcggcgcct ctggactgga ccacgtttcg gcgtgtgttt ctgatcgacg acgcgtggcg 10200 gcccctgatg gagcctgagc tggcgaaccc cttaaccgcc cacctcctgg ccgaatataa 10260 tcgtcggtgc cagaccgaag aggtgctgcc gccgcgggag gatgtgtttt cgtggactcg 10320 ttattgcacc cccgacgagg tgcgcgtggt tatcatcggc caggacccat atcaccaccc 10380 cggccaggcg cacggacttg cgtttagcgt gcgcgcgaac gtgccgcctc ccccgagtct 10440 tcggaatgtc ttggtggccg tcaagaactg ttatcccgag gcacggatga gcggccacgg 10500 ttgcctggaa aagtgggcgc gggacggcgt cctgttacta aacacgaccc tgaccgtcaa 10560 gcgcggggcg gcggcgtccc actctagaat cggttgggac cgcttcgtgg gcggagttat 10620 ccgccggttg gccgcgcgcc gccccggcct ggtgtttatg ctctggggcg cacacgccca 10680 gaatgccatc aggccggacc ctcgggtcca ttgcgtcctc aagttttcgc acccgtcgcc 10740 cctctccaag gttccgttcg gaacctgcca gcatttcctc gtggcgaacc gatacctcga 10800 gacccggtcg atttcaccca tcgactggtc ggtttgaaag gcatcgacgt ccggggtttt 10860 tgtcggtggg ggcttttggg tatttccgat gaataaagac ggttaatggt taaacctctg 10920 gtctcatacg ggtcggtgat gtcgggcgtc gggggagagg gagttccctc tgcgcttgcg 10980 attctagcct cgtggggctg gacgttcgac acgccaaacc acgagtcggg gatatcgcca 11040 gatacgactc ccgcagattc cattcggggg gccgctgtgg cctcacctaa ccaaccttta 11100 cacgggggcc cggaacggga ggccacagcg ccgtctttct ccccaacgcg cgcggatgac 11160 ggcccgccct gtaccgacgg gccctacgtg acgtttgata ccctgtttat ggtgtcgtcg 11220 atcgacgaat tagggcgtcg ccagctcacg gacaccatcc gcaaggacct gcggttgtcg 11280 ctggccaagt ttagcattgc gtgcaccaag acctcctcgt tttcgggaaa cgccccgcgc 11340 caccacagac gcggggcgtt ccagcgcggc acgcgggcgc cgcgcagcaa caaaagcctc 11400 cagatgtttg tgttgtgcaa acgcgcccac gccgctcgag tgcgagagca gcttcgggtc 11460 gttattcagt cccgcaagcc gcgcaagtat tacacgcgat cttcggacgg gcggctctgc 11520 cccgccgtcc ccgtgttcgt ccacgagttc gtctcgtccg agccaatgcg cctccaccga 11580 gataacgtca tgctggcctc gggggccgag taaccgcccc ccccccatgc caccctcact 11640 gcccgtcgcg cgtgtttgat gttaataaat aacacataaa tttggctggt tgtttgttgt 11700 ctttaatgga ccgcccgcaa gggggggggg gcgtttcagt gtcgggtgac gagcgcgatc 11760 cggccgggat cctaggaccc caaaagtttg tctgcgtatt ccagggtggg gctcagttga 11820 atctcccgca gcacctctac cagcaggtcc gcggtgggct ggagaaactc ggccgtcccg 11880 gggcaggcgg ttgtcggggg tggaggcgcg gcgcccaccc cgtgtgccgc gcctggcgtc 11940 tcctctgggg gcgacccgta aatggttgca gtgatgtaaa tggtgtccgc ggtccagacc 12000 acggtcaaaa tgccggccgt ggcgctccgg gcgctttcgc cgcgcgagga gctgacccag 12060 gagtcgaacg gatacgcgta catatgggcg tcccacccgc gttcgagctt ctggttgctg 12120 tcccggccta taaagcggta ggcacaaaat tcggcgcgac agtcgataat caccaacagc 12180 ccaatggggg tgtgctggat aacaacgcct ccgcgcggca ggcggtcctg gcgctcccgg 12240 ccccgtacca tgatcgcgcg ggtgccgtac tcaaaaacat gcaccacctg cgcggcgtcg 12300 ggcagtgcgc tggtcagcga ggccctggcg tggcataggc tatacgcgat ggtcgtctgt 12360 ggattggaca tctcgcggtg ggtagtgagt cccccgggcc gggttcggtg gaactgtaag 12420 gggacggcgg gttaatagac aatgaccacg ttcggatcgc gcagagccga tagtatgtgc 12480 tcactaatga cgtcatcgcg ctcgtggcgc tcccggagcg gatttaagtt catgcgaagg 12540 aattcggagg aggtggtgcg ggacatggcc acgtacgcgc tgttgaggcg caggttgccg 12600 ggcgtaaagc agatggcgac cttgtccagg ctaaggccct gggagcgcgt gatggtcatg 12660 gcaagcttgg agctgatgcc gtagtcggcg tttatggcca tggccagctc cgtagagtca 12720 atggactcga caaactcgct gatgttggtg ttgacgacgg acatgaagcc gtgttggtcc 12780 cgcaagacca cgtaaggcag gggggcctct tccagtaact cggccacgtt ggccgtcgcg 12840 tgccgcctcc gcagctcgtc cgcaaaggca aacacccgtg tgtacgtgta tcccatgagc 12900 gtataattgt ccgtctgcag ggcgacggac atcagccccc cgcgcggcga gccggtcagc 12960 atctcgcagc cccggaagat aacgttgtcc acgtacgtgc taaagggggc gacttcaaat 13020 gcctccccga agagctcttg gaggattcgg aatctcccga ggaaggcccg cttcagcagc 13080 gcaaactggg tgtgaacggc ggcggtggtc tccggttccc cgggggtgta gtggcagtaa 13 140 aacacgtcga gctgttgttc gtccagcccc gcgaaaataa cgtcgaggtc gtcgtcggga 13200 aaatcgtccg ggcccccgtc ccgcggcccc agttgcttaa aatcaaacgc acgctcgccg 13260 ggggcgcctg cgtcggccat taccgacgcc tgcgtcggca cccccgaaga tttggggcgc 13320 agagacagaa tctccgccgt tagttctccc atgcgggcgt acgcgagggt cctctgggtc 13380 gcatccaggc ccgggcgctg cagaaagttg taaaaggaga taagcccgct aaatatgagc 13440 cgcgacagga acctgtaggc aaactccacc gaagtctccc cctgagtctt tacaaagctg 13500 tcgtcacgca acactgcctc gaaggcccgg aacgtcccac taaacccaaa aaccagtttt 13560 cgcaggcgcg cggtcaccgc gatctggctg ttgaggacgt aagtgacgtc gttgcgggcc 13620 acgaccagct gctgtttgct gtgcacctcg cagcgcatgt gccccgcgtc ctggtcctgg 13680 ctctgcgagt agttggtgat gcggctggcg ttggccgtga gccacttttc aatagtcagg 13740 ccgggctggt gtgtcagccg tcggtattcg tcaaactcct tgaccgacac gaacgtaagc 13800 acggggaggg tgaacacgac gaactccccc tcacgggtca ccttcaggta ggcgtggagc 13860 ttggccatgt acgcgctcac ctctttgtgg gaggagaaca gccgcgtcca gccggggagg 13920 ttggcggggt tggtgatgta gttttccggg acgacgaagc gatccacgaa ctgcatgtgc 13980 tcctcggtga tgggcaggcc gtactccagc accttcatga ggttaccgaa ctcgtgctcg 14040 acgcaccgtt tgttgttaat aaaaatggcc cagctatacg agaggcgggc gtactcgcgc 14100 agcgtgcggt tgcagatgag gtacgtgagc acgttctcgc tctggcggac ggaacaccgc 14160 agtttctggt gctcgaaggt cgactccagg gacgccgtct gcgtcggcga gcccacacac 14220 accaacacgg gccgcaggcg ggccgcgtac tggggggtgt ggtacagggc gttaatcatc 14280 caccagcaat acaccacggc cgtgaggagg tgacgcccaa ggagcccggc ctcgtcgatg 14340 acgatcacgt tgctgcgggt aaaggccggc agcgccccgt gggtggccgg ggccaaccgc 14400 gtcagggcgc cctcggccaa ccccagggtc cgttccaggg cggccagggc gcgaaactcg 14460 ttccgcaact cctcgccccc ggaggcggcc agggcgcgct tcgtgaggtc caaaatcacc 14520 tcccagtagt acgtcagatc tcgtcgctgc aggtcctcca gcgaggcggg gttgctggtc 14580 agggtgtacg ggtactgtcc cagttgggcc tggacgtgat tcccgcgaaa cccaaattca 14640 tgaaagatgg tgttgatggg tcggctgaga aaggcgcccg agagtttggc gtacatgttt 14700 tgggccgcaa tgcgcgtggc gcccgtcacc acacagtcca agacctcgtt gattgtctgc 14760 acgcacgtgc tctttccgga gccagcgttg ccggtgataa gatacaccgc gaacggaaac 14820 tccctgaggg gcaggcctgc gggggactct aaggccgcca cgtcccggaa ccactgcaga 14880 cggggcactt gcgctccgtc gagctgttgt tgcgagagct ctcggatgcg cttaaggatt 14940 ggctgcaccc cgtgcataga cgtaaaattt aaaaaggcct cggccctccc tggaacggct 15000 ggtcggtccc cgggttgctg aaggtgcggc gggccgggtt tctgtccgtc tagctggcgc 15060 tccccgccgg ccgccgccat gaccgcacca cgctcgtggg cccccactac gcgtgcgcgg 15120 ggggacacgg aagcgctgtg ctcccccgag gacggctggg taaaggttca ccccaccccc 15180 ggtacgatgc tgttccgtga gattctccac gggcagctgg ggtataccga gggccagggg 15240 gtgtacaacg tcgtccggtc cagcgaggcg accacccggc agctgcaggc ggcgatcttt 15300 cacgcgctcc tcaacgccac cacttaccgg gacctcgagg cggactggct cggccacgtg 15360 gcggcccgcg gtctgcagcc ccaacggctg gttcgccggt acaggaacgc ccgggaggcg 15420 gatatcgccg gggtggccga gcgggtgttc gacacgtggc ggaacacgct taggacgacg 15480 ctgctggact ttgcccacgg gttggtcgcc tgctttgcgc cgggcggccc gagcggcccg 15540 tcaagcttcc ccaaatatat cgactggctg acgtgcctgg ggctggtccc catattacgc 15600 aagcgacaag aagggggtgt gacgcagggt ctgagggcgt ttctcaagca gcacccgctg 15660 acccgccagc tggccacggt cgcggaggcc gcggagcgcg ccggccccgg gttttttgag 15720 ctggcgctgg ccttcgactc cacgcgcgtg gcggactacg accgcgtgta tatctactac 15780 aaccaccgcc ggggcgactg gctcgtgcga gaccccatca gcgggcagcg cggagaatgt 15840 ctggtgctgt ggcccccctt gtggaccggg gaccgtctgg tcttcgattc gcccgtccag 15900 cggctgtttc ccgagatcgt cgcgtgtcac tccctccggg aacacgcgca cgtctgccgg 15960 ctgcgcaata ccgcgtccgt caaggtgctg ctggggcgca agagcgacag cgagcgcggg 16020 gtggccggtg ccgcgcgggt cgttaacaag gtgttggggg aggacgacga gaccaaggcc 16080 gggtcggccg cctcgcgcct cgtgcggctt atcatcaaca tgaagggcat gcgccacgta 16140 ggcgacatta acgacaccgt gcgtgcctac ctcgacgagg ccggggggca cctgatagac 16200 gccccggccg tcgacggtac cctccctgga ttcggcaagg gcggaaacag ccgcgggtct 16260 gcgggccagg accagggggg gcgggcgccg cagcttcgcc aggccttccg cacggccgtg 16320 gttaacaaca tcaacggcgt gttggagggc tatataaata acctgtttgg aaccatcgag 16380 cgcctgcgcg agaccaacgc gggcctggcg acccaattgc aggagcgcga ccgcgagctc 16440 cggcgcgcaa cagcgggggc cctggagcgc cagcagcgcg cggccgacct ggcggccgag 16500 tccgtgaccg gtggatgcgg cagccgccct gcgggggcgg acctgctccg ggccgactat 16560 gacattatcg acgtcagcaa gtccatggac gacgacacgt acgtcgccaa cagctttcag 16620 cacccgtaca tcccttcgta cgcccaggac ctggagcgcc tgtcgcgcct ctgggagcac 16680 gagctggtgc gctgttttaa aattctgtgt caccgcaaca accagggcca agagacgtcg 16740 atctcgtact ccagcggggc gatcgccgca ttcgtcgccc cctactttga gtcagtgctt 16800 cgggcccccc gggtaggcgc gcccatcacg ggctccgatg tcatcctggg ggaggaggag 16860 ttatgggatg cggtgtttaa gaaaacccgc ctgcaaacgt acctgacaga catcgcggcc 16920 ctgttcgtcg cggacgtcca gcacgcagcg ctgcccccgc ccccctcccc ggtcggcgcc 16980 gatttccggc ccggcgcgtc cccgcggggc cggtccagat cgcggtcgcc cggaagaact 17040 gcgccaggcg cgccggacca gggcgggggc atcgggcacc gggatggccg ccgcgacggc 17 100 cgacgatgag gggtcggccg ccaccatcct caagcaggcc atcgccgggg accgcagcct 17160 ggtcgaggcg gccgaggcga ttagccagca gacgctgctc cgcctggcct gcgaggtgcg 17220 ccaggtcggc gaccgccagc cgcggtttac cgccaccagc atcgcgcgcg tcgacgtcgc 17280 gcctgggtgc cggttgcggt tcgttctgga cgggagtccc gaggacgcct atgtgacgtc 17340 ggaggattac tttaagcgct gctgcggcca gtccagttat cgcggcttcg cggtggcggt 17400 cctgacggcc aacgaggacc acgtgcacag cctggccgtg ccccccctcg ttctgctgca 17460 ccggttctcc ctgttcaacc ccagggacct cctggacttt gagcttgcct gtctgctgat 17520 gtacctggag aactgccccc gaagccacgc caccccgtcg acctttgcca aggttctggc 17580 gtggctcggg gtcgcgggtc gccgcacgtc cccattcgaa cgcgttcgct gccttttcct 17640 ccgcagttgc cactgggtcc taaacacact catgttcatg gtgcacgtaa aaccgttcga 17700 cgacgagttc gtcctgcccc actggtacat ggcccggtac ctgctggcca acaacccgcc 17760 ccccgttctc tcggccctgt tctgtgccac cccgacgagc tcctcattcc ggctgccggg 17820 gccgcccccc cgctccgact gcgtggccta taaccccgcc gggatcatgg ggagctgctg 17880 ggcgtcggag gaggtgcgcg cgcctctggt ctattggtgg ctttcggaga ccccaaaacg 17940 acagacgtcg tcgctgtttt atcagttttg ttgaatttta ggaaataaac ccggttttgt 18000 ttctgtggcc tcccgacgga tgcgcgtgtc cttcctccgt cttggtgggt gggtgtctgt 18060 gtatcgcgtc ccatctgtgc ggagaggggg ggcatgtcgg cacgtattcg gacagactca 18120 agcacacacg ggggagcgct cttgtctcag ggcaatgttt ttattggtca aactcaggca 18180 aacagaaacg acatcttgtc gtcaaaggga tacacaaact tccccccctc tccccatact 18240 cccgccagca ccccggtaaa caccaactca atctcgcgca ggatttcgcg caggtgatga 18300 gcgcagtcca cgggggggag cacaaggggc cgcgggtata gatcgacggg gacgccgacc 18360 gactccccgc ctccgggaca gacacgcacg acgcgccgcc agtagtgctc tgcgtccagc 18420 aaggcgccgc cgcggaaggc agtggggggc aaggggtcgc tagcctcaaa gggggacacc 18480 cgaacgctcc agtactccgc gtccaaccgt ttattaaacg cgtccacgat aaggcggtcg 18540 caggcgtcct ccataaggcc ccgggccgtg agtgcgtcct cctccggcac gcctgccgtt 18600 gtcaggccca ggacccgtcg cagcgtgtcg cgtacgaccc cggccgccgt ggtgtacgcg 18660 ggcccgcgga gaggaaatcc cccaagatgg tcagtgttgt cgcgggagtt ccagaaccac 18720 actcccgcct ggttccaggc gactgcgtgg gtgtagacgc cctcgagggc caggcacagt 18780 gggtgccgca gccggaggcc gttggcccta agcacggctc ccacggccgt ctcgatggcc 18840 cgccgggcgt cctcgatcac cccggaagcc gcatccgcgt cttgggggtc cacgttaaag 18900 acaccccaga acgcaccccc atcgcccccg cagaccgcga acttcaccga gctggccgtc 18960 tcctcgatct gcaggcagac ggcggccatt accccaccca ggagctgccg cagcgcaggg 19020 caggcgtcgc acgtgtccgg gaccaggcgc tccaagacgg ccccggccca gggctctgag 19080 ggagcggcca ccaccagcgc gtccagtctt gctaggcccg tccggccgtg ggggtccgcc 19140 agcccgctcc ccccgaggtc ggccagggcc gccaggagct gggcgcgaag tccggggaag 19200 caaaaccgcg ccgtccagac gggcccgacg gccgcgggcg ggtctaacag ttggatgatt 19260 ttagtggcgg gatgccaccg cgccaccgcc tcccgcaccg cgggcaggag gcatccggct 19320 gccgccgagg ccacgccggg ccaggctcgc ggggggagga cgaccctggc ccccaccgcg 19380 ggccaggccc ccaggagcgc ggcgtaagcg gccgcggccc cgcgcaccag gtcccgtgcc 19440 gactcggccg tggccggcac ggtgaacgtg ggccaacccg gaaaccccag gacggcaaag 19500 tacgggacgg gtcccccccg gacctcaaac tcgggcccca gaaaggcaaa gacgggggcc 19560 agggccccgg gggcggcgtg gaccgtggta tgccactgcc ggaaaagggc gacgagcgcc 19620 ggcgcggaga acttctcgcc ggcgcttaca aagtagtcgt aatcgcgggg cagcagcacc 19680 cgtgccgtga ctcgttgcgg gtgcccgcgt ggccgcaggc ccacctcgca cacctcgacc 19740 aggtccccga acgcgccctc cttcttgatc ggcggaaacg caagagtctg gtattcgcgc 19800 gcaaatagcg cggttccggt ggtgatgtta acggtcagcg aagcggcgga cgcgcactgg 19860 ggggtgtcgc gaatggccgc caggcgcgcc cacgccagcc gcgcgtcggg atgctcggca 19920 acgcgcgccg ccagggccat agggtcgatg tcaatgttgg cctccgcgac caggagagcg 19980 gcgcgagggg cggcgggcgg gccccacgac gctctctcaa ctttcaccac cagtcccgtg 20040 cgtgggtccg agccgatacg cagcggggcg aacagggcca ccggcccggt ctggcgctcc 20 100 agggccgcca ggacgcacgc gtacagcgcc cgccacagag tcgggttctc caggggctcc 20160 agcggggagg cggccggcgt cgtcgcggcg cgggcggccg ccacgacggc ctggacggag 20220 acgtccgcgg agccgtagaa atcccgcagc tccgtcgcgg tgacggagac ctccgcaaag 20280 cgcgcgcgac cctcccctgc ggcgttgcga catacaaaat acaccagggc gtggaagtac 20340 tcgcgagcgc gggggggcag ccataccgcg taaagggtaa tggcgctgac gctctcctcc 20400 acccacacga tatctgcggt gtccatcgca cggcccctaa ggatcacggg cggtctgtgg 20460 gtcccatgct gccgtgcctg gccgggcccg gtgggtcgcg gaaaccggtg acgggggggg 20520 ggcggttttt ggggttgggg tgggggtggg aaacggcccg ggtccggggg ccaacttggc 20580 ccctcggtgc gttccggcaa cagcgccgcc ggtccgcgga cgaccacgta ccgaacgagt 20640 gcggtcccga gacttatagg gtgctaaagt tcaccgcccc ctgcatcatg ggccaggcct 20700 cggtggggag ctccgacagc gccgcctcca ggatgatgtc agcgttgggg ttggcgctgg 20760 atgagtgcgt gcgcaaacag cgcccccacg caggcacgcg tagcttgaag cgcgcgcccg 20820 caaactcccg cttgtgggcc ataagcaggg cgtacagctg cctgtgggtc cggcaggcgc 20880 tgtggtcgat gtggtgggcg tccaacaacc ccacgattgt ctgtttggtg aggtttttaa 20940 cgcgccccgc cccgggaaac gtctgcgtgc ttttggccat ctgcacgcca aacagttcgc 21000 cccagattat cttgaacagc gccaccgcgt ggtccgtctc gctaacggac ccgcgcgggg 21060 gacagccgct tagggcgtcg gcgacgcgct tgacggcttc ctccgagagc agaagtccgt 21120 cggttacgtt acagtggccc agttcgaaca ccagctgcat gtagcggtcg tagtgggggg 21180 tcagtaggtc cagcacgtca tcggggccga aggtcctccc agatcccccg gccgccgagt 21240 cccaatgcag gcgcgcggcc atggtgctgc acaggcacaa cagctcccag acgggggtta 21300 cgttcagggt ggggggcagg gccacgagct ccagctctcc ggtgacgttg atcgtgggga 21360 tgacgcccgt ggcgtagtgg tcatagatcc gccgaaatat ggcgctgctg cgggtggcca 21420 tgggaacgcg gagacaggcc tccagcaacg ccaggtaaat aaaccgcgtg cgtcccatca 21480 ggctgttgag gttgcgcatg agcgcgacaa tttccgccgg cgcgacatcg gaccggaggt 21540 atttttcgac gaaaagaccc acctcctccg tctcggcggc ctgggccggc agcgacgcct 21600 cgggatcccg gcaccgcagc tcccgtagat cgcgctgggc cctgagggcg tcgaaatgta 21660 cgccccgcaa aaacagacag aagtcctttg gggtcagggt atcgtcgtgt ccccagaagc 21720 gcacgcgtat gcagtttagg gtcagcagca tgtgaaggat gttaaggctg tccgagagac 21780 acgccagcgt gcatctctca aagtagtgtt tgtaacggaa tttgttgtag atgcgcgacc 21840 cccgccccag cgacgtgtcg catgccgacg cgtcacagcg ccccttgaac cggcgacaca 21900 gcaggtttgt gacctgggag aactgcgcgg gccactggcc gcaggaactg accacgtgat 21960 taaggagcat gggcgtaaag acgggctccg agcgcgcccc ggagccgtcc atgtaaatca 22020 gtagctcccc cttgcggagg gtgcgcaccc gtcccaggga ctggtacacg gacaccatgt 22080 ccggtccgta gttcatgggt tttacgtagg cgaacatgcc atcaaagtgc aggggatcga 22140 agctgaggcc cacggttacg accgtcgtgt atataaccac gcggtattgg ccccacgtgg 22200 tcacgtcccc gaggggggtg agcgagtgaa gcaacagcac gcggtccgta aactgacggc 22260 agaaccgggc cacgatctcc gcgaaggaga ccgtcgacga aaaaatgcag atgttatcgc 22320 ccccgccaag gcgcgcttcc agctccccaa agaacgtggc cccccgggcg tccggagagg 22380 cgtccggaga cgggccgctc ggcggcccgg gcgggcgcag ggcagcctgc aggagctcgg 22440 tccccagacg cgggagaaac aggcaccggc gcgccgaaaa cccgggcatg gcgtactcgc 22500 cgaccaccac atgcacgttt ttttcgcccc ggagaccgca caggaagtcc accaactgcg 22560 cgttggcggt tgcgtccatg gcgatgatcc gaggacaggt gcgcagcagg cgtagcatta 22620 acgcatccac gcggcccagt tgctgcatcg ttggcgaata gagctggccc agcgtcgaca 22680 taacctcgtc cagaacgagg acgtcgtagt tgttcagaag gttggggccc acgcgatgaa 22740 ggctttccac ctggacgata agtcggtgga aggggcggtc gttcataatg taattggtgg 22800 atgagaagta ggtgacaaag tcgaccaggc ctgactcagc gaaccgcgtc gccagggtct 22860 gggtaaaact ccgacgacag gagacgacga gcacactcgt gtccggagag tggatcgctt 22920 cccgcagcca gcggatcagc gcggtagttt ttcccgaccc cattggcgcg cggaccacag 22980 tcacgcacct ggccgtcggg gcgctcgcgt tggggaaggt gacgggtccg tgctgctgcc 23040 gctcgatcgt tgttttcggg tgaacccggg gcacccattc ggccaaatcc cccccgtaca 23100 acatccgcgc tagcgatacg ctcgacgtgt actgttcgca ctcgtcgtcc ccaatgggac 23160 gcccggcccc cagaggatct cccgactccg cgccccccac gaaaggcatg accggggcgc 23220 ggacggcgtg gtgggtctgg tgtgtgcagg tggcgacgtt tgtggtctct gcggtctgcg 23280 tcacggggct cctcgtcctg gcctctgtgt tccgggcacg gtttccctgc ttttacgcca 23340 cggcgagctc ttatgccggg gtgaactcca cggccgaggt gcgcgggggt gtagccgtgc 23400 ccctcaggtt ggacacgcag agccttgtgg gcacttatgt aatcacggcc gtgttgttgt 23460 tggccgcggc cgtgtatgcc gtggtcggcg ccgtgacctc ccgctacgac cgcgccctgg 23520 acgcgggccg ccgtctggct gcggcccgca tggccatgcc gcacgccacg ctgatcgccg 23580 gaaacgtctg ctcttggttg ctgcagatca ccgtcctgtt gctggcccat cgcaccagcc 23640 agctggccca cctggtttac gtcctgcact ttgcgtgtct ggtgtatttt gcggcccatt 23700 tttgcaccag gggggtcctg agcgggacgt atctgcgtca ggtgcacggc ctgatggagc 23760 cggccccgac tcatcatcgc gtcgttggcc cggctcgagc cgtgctgaca aacgccttgc 23820 tgttgggcgt cttcctgtgc acggccgacg ccgcggtatc cctgaatacc atcgccgcgt 23880 tcaactttaa tttttcggcc ccgggcatgc tcatatgcct gaccgtgctg ttcgcccttc 23940 tcgtcgtatc gctgttgttg gtggtcgagg gggtgttgtg tcactacgtg cgcgtgttgg 24000 tgggccccca cctgggggcc gtggccgcca cgggcatcgt cggcctggca tgcgagcact 24060 attacaccaa cggctactac gttgtggaga cgcagtggcc gggggcccag acgggagtcc 24120 gcgtcgccct cgccctggtc gccgcctttg ccctcggcat ggccgtgctc cgctgcaccc 24180 gcgcctatct gtatcacagg cggcaccaca ccaaattttt tatgcgcatg cgcgacacgc 24240 gacaccgcgc acattccgcc ctcaagcgcg tacgcagttc catgcgcgga tcgcgagacg 24300 gccgccacag gcccgcaccc ggcagcccgc ccgggattcc cgaatatgcg gaagacccct 24360 acgcgatctc atacggcggc cagctcgacc ggtacggaga ttccgacggg gagccgattt 24420 acgacgaggt ggcggacgac caaaccgacg tattgtacgc caagatacaa cacccgcggc 24480 acctgcccga cgacgagccc atctatgaca ccgttggggg gtacgacccc gagcccgccg 24540 aggaccccgt gtacagcacc gtccgccgtt ggtagctgtt tggttccgtt ttaataaacc 24600 gtttgtgttt aacccgaccg tggtgtatgt ctggtgtgtg gcgtccgatc ccgttactat 24660 caccgttccc cccaaacccc ggcgattgtg ggttttttta aaaacgacac gcgtgcgacc 24720 gtatacagaa cattgttgtt ttttattcgc tatcggacat ggggggtgga aactgggtgg 24780 cggggcaggc gcctccgggg gttcgccggt gagtgtggcg cgagggggga tccgacgaac 24840 gcaggcgctg tctccccggg gcccgcgtaa ccccgcgcat atccgggggc acgtagaaat 24900 taccttcctc ttcggactcg atatccacga cgtcaaagtc gtgggcggtc agcgagacga 24960 cctccccgtc gtcggtgatg aggacgttgt ttcggcagca gcagggccgg gtcccggaga 25020 acgagaggcc catagctcgg cgagcgtgtc gtcgaacgcc aggcggctgc ttcgctgtat 25080 ggccttatag atctccggat cgatgcggac gggggtaatg atcagggcga tcggaacggc 25140 ctggttcggg agaatggacg ccttgctggg tcctgcggcc ccgagagccc cggcgccgtc 25200 ctccaggcgg aacgttacgc cctcctccgc gctagtgcgg tgcctgccga taaacgtcac 25260 cagatgcggg tggggggggc agtcggggaa gtggctgtcg agcacgtagc cctgcaccaa 25320 gatctgctta aagttcgggt gacgggggtt cgcgaagacg ggctcgcggc gtaccagatc 25380 cccggagctc caggacacgg gggagatggt gtggcgtccg aggtcggggg cgccaaacag 25440 aagcacctcc gagacaacgc cgctatttaa ctccaccaag gcccgatccg cggcggagca 25500 ccgccttttt tcgcccgagg cgtgggggcctc tgaccaggcc tggtcttgcg tgacgagagc 25560 ctcctccggg ccggggacgc gcccgggcgc gaagtatcgc acgctgggct tcgggatcga 25620 ccggataaat gcccggaacg cctccgggga ccggtgtgcc atcaagtcct cgtacgcgga 25680 ggccgtgggg tcgctggggt ccatggggtc gaaagcgtac ttggcccggc atttgacctc 25740 gtaaaaggcc aggggggtct tggggactgg ggccaagtag ccgtgaatgt cccgaggaca 25800 gacgagaata tccagggacg ccccgaccat ccccgtgtga ccgtccatga ggaccccaca 25860 cgtatgcacg ttctcttcgg cgaggtcgcc gggttcgtgg aagataaagc gccgcgtgtc 25920 ggcgccggcc tcgccgccgt cgtccgcgcg gcccacgcag tagcgaaaca gcaggcttcg 25980 ggccgtcggc tcgttcaccc gcccgaacat caccgccgaa gactgtacat ccggccgcag 26040 gctggcgttg tgcttcagcc actggggcga gaaacacgga ccctgggggc cccagcggag 26100 ggtggatgcg gtcgtgaggc cccgccggag cagggcccat agctggcagt cggcctggtt 26160 ttgcgtggcc gcctcgtaaa accccatgag gggccggggc gccacggcgt ccgcggcggc 26220 cgggggcccg cggcgcgtca ggcgccatag gtgccggccg agtccgcggt ccaccatacc 26280 cgcctcctcg aggaccacgg ccagggaaca cagataatcc aggcgggccc agaggggacc 26340 gatggccaga ggggcgcgga cgccgcgcag caacccgcgc aggtggcgct cgaacgtctc 26400 ggctagtata tgggagggca gcgcgttggg gatcaccgac gccgaccaca tagagtcaag 26460 gtccggggag tcgggatcgg cgtccgggtc gcgggcgtgg gtgcccccag gagatagcgg 26520 aatgtctggg gtcggaggcc ctgaggcgtc agaaagtgcc ggcgacgcgg cccggggctt 26580 ttcgtctgcg gtgtcggtgg cgtgctgatc acgtgggggg ttaacgggcg aatgggagct 26640 cgggtccaca gctgacgtcg tctggggtgg ggggggcagg ggacggaagg tggttgttag 26700 cggaagactg ttagggcggg ggcgcttggg ggggctgtcg gggccacgag gggtgtcctc 26760 ggccagggcc caggaacgct tagtcacggt gcgtcccggc ggacatgctg ggcctcccgt 26820 ggactccatt tccgagacga cgtgggggga gcggtggttg agcgcgccgc cgggtgaacg 26880 ctgattctca cgacagcgcg tgccgcgcgc acgggttggt gtgacacagg cgggacacca 26940 gcaccaggag aggcttaagc tcgggaggca gcgccaccga cgacagtatc gccttgtgtg 27000 tgtgctggta atttatacac cgatccgtaa acgcgcgccg aatcttggga ttgcggaggt 27060 ggcgccggat gccctctggg acgtcatacg ccaggccgtg ggtgttggtc tcggccgagt 27120 tgacaaacag ggctgggtgc agcacgcggc gataggcgag cagggccagg gcgaagtcca 27180 gcgacagctg gttgttgaaa tactggtaac cgggaaaccg ggtcacgggt acgcccaggc 27240 tcggggcgac gtacacgcta accaccaact ccagcagcgt ctggccaagg gcgtacaggt 27300 caaccgctaa cccgacgtcg tgcttcaggc ggtggttggt aaattcggcc cgttcgttgt 27360 taaggtattt caccaacagc tccgggggct ggttataccc gtgacccacc agggtgtgaa 27420 agttggctgt ggttagggcg gtgggcatgc caaacatccg gggggacttg aggtccggct 27480 cctggaggca aaactgcccc cgggcgatcg tggagttgga gttgagggtg acgaggctaa 27540 agtcggcgag gacggcccgc cggagcgaga cggcgtccga ccgcagcatg acgaggatgt 27600 tggcgcactt gatatccagg tggctgatcc cgcaggtggt gtttaaaaac acaacggcgc 27660 gggccagctc cgtgaagcac tggtggaggg ccgtcgagac cgaggggttt gttgtgcgca 27720 gggacgccag ttggccgata tacttaccga ggtccatgtc gtacgcgggg aacactatct 27780 gtcgttgttg cagcgagaac ccgaggggcg cgatgaagcc gcggatgttg tgggtgcggc 27840 cggcgcgtag agcgcactcc ccgaccaaca gggtcgcgat gagctcaacg gcaaaccact 27900 ccttttcctt tatggtctta acggcaagct tatgttcgcg aatcagttgg acgtcgccgt 27960 atcccccaga ccccccgaag cttcgggccc cggggatctc gagggtcgtg tagtgtaggg 28020 cggggttgat ggcgaacacg gggctgcata gcttgcggat gcgcgtgagg gtaaggatgt 28080 gcgaggggga cgaggggggt gcggttaacg ccgcctggga tctgcgcagg ggcgggcggt 28 140 tcagtttggc cgccgtaccg ggcgtctcgg gggacgcgcg gcgatgagac gagcggctca 28200 ttcgccatcg ggatagtccc gcgcgaagcc gctcgcggag gccggatcgg tggcgggacc 28260 cgtgggagga gcgggagccg gcggcgtcct ggagagaggg gccgctgggg cgcccggagg 28320 ccccgtgtgg gttggagtgt atgtaggatg cgagccaatc cttgaaggac tgttggcgtg 28380 caccttgggg gctgaggtta gctgccacat gaccagcagg tcgctgtctg cgggactcat 28440 ccatccttcg gccaggtcgc cgtcttccca cagagaagcg ttggtcgctg cttcctcgag 28500 ttgctcctcc tggtccgcaa gacgatcgtc cacggcgtcc aggcgctcac caagcgccgg 28560 atcgaggtac cgtcggtgtg cggttagaaa gtcacgacgc gccgcttgct cctccacgcg 28620 aattttaaca caggtcgcgc gctgtcgcat catctctaag cgcgcgcggg actttagccg 28680 cgcctccaat tccaagtggg ccgcctttgc agccataaag gcgccaacaa accgaggatc 28740 ttgggtgctg acgccctccc ggtgcagctg cagggtctgg tccttgtaaa tctcggctcg 28800 gaggtgcgtc tcggccaggc gtcggcgcag ggccgcgtgg gcggcatctc ggtccattcc 28860 gccaccctgc gggcgacccg gggggtgctc tgatagtctc gcgtgcccaa ggcccgtgat 28920 cggggtactt cgccgccgcg acccgccacc cggtgtgcgc gatgtttggt cagcagctgg 28980 cgtccgacgt ccagcagtac ctggagcgcc tcgagaaaca gaggcaactt aaggtgggcg 29040 cggacgaggc gtcggcgggc ctcacaatgg gcggcgatgc cctacgagtg ccctttttag 29100 atttcgcgac cgcgaccccc aagcgccacc agaccgtggt cccgggcgtc gggacgctcc 29160 acgactgctg cgagcactcg ccgctcttct cggccgtggc gcggcggctg ctgtttaata 29220 gcctggtgcc ggcgcaacta aaggggcgtg atttcggggg cgaccacacg gccaagctgg 29280 aattcctggc ccccgagttg gtacgggcgg tggcgcgact gcggtttaag gagtgcgcgc 29340 cggcggacgt ggtgcctcag cgtaacgcct actatagcgt tctgaacacg tttcaggccc 29400 tccaccgctc cgaagccttt cgccagctgg tgcactttgt gcgggacttt gcccagctgc 29460 ttaaaacctc cttccgggcc tccagcctca cggagaccac gggcccccca aaaaaacggg 29520 ccaaggtgga cgtggccacc cacggccgga cgtacggcac gctggagctg ttccaaaaaa 29580 tgatccttat gcacgccacc tactttctgg ccgccgtgct cctcggggac cacgcggagc 29640 aggtcaacac gttcctgcgt ctcgtgtttg agatccccct gtttagcgac gcggccgtgc 29700 gccacttccg ccagcgcgcc accgtgtttc tcgtcccccg gcgccacggc aagacctggt 29760 ttctagtgcc cctcatcgcg ctgtcgctgg cctcctttcg ggggatcaag atcggctaca 29820 cggcgcacat ccgcaaggcg accgagccgg tgtttgagga gatcgacgcc tgcctgcggg 29880 gctggttcgg ttcggcccga gtggaccacg ttaaagggga aaccatctcc ttctcgtttc 29940 cggacgggtc gcgcagtacc atcgtgtttg cctccagcca caacacaaac gtaagtcctc 30000 ttttctttcg catggctctc ccaaggggcc ccgggtcgac ccgacccaca cccacccacc 30060 cacccacata cacacacaac cagacgcggg aggaaagtct gccccgtggg cactgatttt 30120 tattcgggat cgcttgagga ggcccgggca acggcccggg caacggtggg gcaactcgta 30180 gcaaataggc gactgatgta cgaagagaag acacacaggc gccacccggc gctggtcggg 30240 gggatgttgt ccgcgccgca ccgtcccccg acgacctctt gcagacggtc cgtgatgcaa 30300 ggacggcggg gggcctgcag cagggtgacc gtatccacgg gatggccaaa gagaagcgga 30360 cacaggctag catccccctg gaccgccagg gtacactggg ccatcttggc ccacagacac 30420 ggggcgacgc agggacagga ctccgttacg acggaggaga gccacagtgc gttggcggaa 30480 tcgatgtggg gcggcggggc gcaggactcg cagccccccg ggtggttggt gatcctggcc 30540 aggagccatc ccagatggcg ggccctgctt cccggtggac agagcgaccc caggtcgctg 30600 tccatggccc agcagtagat ctggccgctg gggaggtgcc accaggcccc cgggcccaag 30660 gcgcaacacg cgcccggctc cgggggggtc ttcgcgggga ccagatacgc gccatccagc 30720 tcgccgacca ctggctcctc cgcgagctgt tcggtggttg ggtcgggggt ttcctccggg 30780 ggggtggccg cccgtatgcg ggcgaacgtg agggtgcaca ggagcggggt cagggggtgc 30840 gtcacgctcc ggaggtggac gatcgcgcag tagcggcgct cgcggttaaa gaaaaagagg 30900 gcaaagaagg tgttcggggg caaccgcagc gccttggggc gcgtcagata cagaaaaatc 30960 tcgcagaaga gggcgcgccc ggggtctggg ttaggaaggg ccacctgaca cagaggctcg 31020 gtgaggaccg ttagacaccg aaagatcttg agccgctcgt ccgcccgaac gacgcgccac 31080 acaaagacgg agttgacaat gcgcgcgata gagtcgacgt ccgtccccag gtcgtcgact 31140 ctgtcgcgcg tgccgcgagc tccggcccgg gaatccggcc ggggcaaggt ccccggggga 31200 ccaggcggcg ccaggggccg ccggggtccc agctgcgcca tgccgggggc ggggggaggg 31260 caaaccccag aggcgggggc caacggcgcg gggaggagtg ggtgggcgag gtggccgggg 31320 gaaggcgccc gctagcgaga acggccgttc ccggacgaca ccttgcgaca aaacctaagg 31380 acagcggccc gcgcgacggg gtccgagagg ctaaggtagg ccgcgatgtt aatggtgaac 31440 gcaaagccgc cgggaaagac aactatgcca cagaggcggc gattaaaccc caggcagagg 31500 taggcgtagc tttccccggg caggtattgc tcgcagaccc tgcgtggggc tgtggagggg 31560 acggcctcca tgaagcgaca tttactctgc tcgcgtttac tgacgtcacc atccatcgcc 31620 acggcgattg gacgattgtt aagccgcagc gtgtctccgc ttgtgctgta gtagtcaaaa 31680 acgtaatggc cgtcggagtc ggcaaagcgg gccgggaggt cgtcgccgag cgggacgacc 31740 cgccgccccc gaccgccccg tccccccagg tgtgccagga cggccagggc atacgcggtg 31800 tgaaaaaagg cgtcgggggc ggtcccctcg acggcgcgca tcaggttctc gaggagaatg 31860 gggaagcgcc tggtcacctc ccccagccac gcgcgttggt cggggccaaa gtcatagcgc 31920 aggcgctgtg agattcgagg gccgccctga agcgcggccc ggatggcctg gcccagggcc 31980 cggaggcacg ccagatgtat gcgcgcagta aaggcgacct cggcggcgat gtcaaagggc 32040 ggcaggacgg ggcgcgggtg gcgcaggggc acctcgagcg cgggaaagcg gagcagcagc 32 100 tccgcctgcc cagcgggaga cagctggtgg gggcgcacga cgcgttctgc ggcgcaggcc 32160 tcggtcaggg ccgtggccag cgccgaggac agcagcggag ggcgggcgcg tcgcccgccc 32220 cacgccacgg agttctcgta ggagacgacg acgaagcgct gcttggttcc gtagtggtgg 32280 cgcaggacca cggagataga acgacggctc cacagccagt ccggccggtc gccgccggcc 32340 agggcttccc atccgcgatc caaccactcg accagcgacc gcggctttgc ggtaccaggg 32400 gtcagggtta gaacgtcgtt caggatgtcc tcgcccccgg gcccgtgggg cactggggcc 32460 acaaagcggc ccccgcctgg gggctccaga cccgccaaca ccgcatctgc gtcagccgcc 32520 cccatggcgc ccccgctgac ggcctggtga accagggcgc cctggcggag ccccgatgca 32580 acgccacagg ccgcacgccc ggtccgagcg cggaccgggt ggcggcgggt gacgtcctgc 32640 actgcccgct gaaccaacgc gaggatctcc tcgttctcct gcgcgatgga cacgtcctgg 32700 gccgcggtcg tgtcgccgcc gggggccgtc agctgctcct ccggggagat gggggggtcg 32760 gacgccccga cgatgggcgg gtctgcgggc gcccccgcgt ggggccgggc caagggctgc 32820 ggacgcgggg acgcgctttc ccccagaccc atggacaggt gggccgcagc ctccttcgcg 32880 gccggcgggg cggcggcgcc aagcagagcg acgtagcggc acaaatgccg acagacgcgc 32940 atgatgcgcg tgctgtcggc cgcgtagcgc gtgttggggg ggacgagctc gtcgtaacta 33000 aacagaatca cgcgggcaca gctcgccccc gagccccacg caaggcgcag cgccgccacg 33060 gcgtacgggt catagacgcc ctgtgcgtca cacaccacgg gcaaggagac gaacaacccc 33120 ccggcgctgg acgcacgcgg aaggaggcca gggtgtgccg gcacgacggg ggccagaagc 33180 tcccccaccg catccgcggg cacgtaggcg gcaaacgccg tgcaccacgg ggtacagtcg 33 240 ccggtggcat gagcccgagt ctggatttcg acctggaagt ttgcggccgt cccgagtccg 33300 gggcggccgc gcatcagggc ggccagaggg attcccgcgg ccgccaggca ctcgctggat 33360 atgatgacgt gaaccaaaga cgagggccga cccgggacgt ggccgagatc gtactggacc 33420 tcgttggcca agtgcgcgtt catggttcgg gggtgggtgt gggtgtgtag gcgatgcggg 33480 tcccccgagt ccgcgggaag ggcgcgggtt tggcgcgcgt atgcgtattc gccaacggag 33540 gcgtgcgtgc ttatgcgcgg cgcgtttctt ctgtctccag ggaatccgag gccaggactt 33600 taacctgctc tttgtcgacg aggccaactt tattcgcccg gatgcggtcc agacgattat 33660 gggctttctc aaccaggcca actgcaagat tatcttcgtg tcgtccacca acaccgggaa 33720 ggccagtacg agctttttgt acaacctccg cggggccgcc gacgagcttc tcaacgtggt 33780 gacctatata tgcgatgatc acatgccgcg ggtggtgacg cacacaaacg ccacggcctg 33840 ttcttgttat atcctcaaca agcccgtttt catcacgatg gacggggcgg ttcgccggac 33900 cgccgatttg tttctggccg attccttcat gcaggagatc atcgggggcc aggccaggga 33960 gaccggcgac gaccggcccg ttctgaccaa gtctgcgggg gagcggtttc tgttgtaccg 34020 cccctcgacc accaccaaca gcggcctcat ggcccccgat ttgtacgtgt acgtggatcc 34080 cgcgttcacg gccaacaccc gagcctccgg gaccggcgtc gctgtcgtcg ggcggtaccg 34140 cgacgattat atcatcttcg ccctggagca cttttttctc cgcgcgctca cgggctcggc 34200 ccccgccgac atcgcccgct gcgtcgtcca cagtctgacg caggtcctgg ccctgcatcc 34260 cggggcgttt cgcggcgtcc gggtggcggt cgagggaaat agcagccagg actcggccgt 34320 cgccatcgcc acgcacgtgc acacagagat gcaccgccta ctggcctcgg agggggccga 34380 cgcgggctcg ggccccgagc ttctcttcta ccactgcgag cctcccggga gcgcggtgct 34440 gtaccccttt ttcctgctca acaaacagaa gacgcccgcc tttgaacact ttattaaaaa 34500 gtttaactcc gggggcgtca tggcctccca ggagatcgtt tccgcgacgg tgcgcctgca 34560 gaccgacccg gtcgagtatc tgctcgagca gctgaataac ctcaccgaaa ccgtctcccc 34620 caacacggac gtccgtacgt attccggaaa acggaacggc gcctcggatg accttatggt 34680 cgccgtcatt atggccatct accttgcggc ccaggccgga cctccgcaca cattcgctcc 34740 catcacacgc gtttcgtgag cgcccaataa acacacccag gtatgctacg cacgaccacg 34800 gtgtcgcctg ttaagggggg gggaaggggg tgttggcggg aagcgtggga acacggggga 34860 ttctctcacg accggcacca gtaccacccc cctgtgaaca cagaaacccc aacccaaatc 34920 ccataaacat acgacacaca ggcatatttt ggaatttctt aggtttttat ttatttaggt 34980 atgctggggt ttctccctgg atgcccaccc ccaccccccc ccgtgggtct agccgggcct 35040 tagggatagc gtataacggg ggccatgtct ccggaccgca caacggccgc gccgtcaaag 35 100 gtgcacaccc gaaccacggg agccagggcc aaggtgtctc ctagttggcc cgcgtgggtc 35 160 agccaggcga cgagcgcctc gtagagcggc agccttcgct ctccatcctg catcagggcc 35220 ggggcttcgg ggtgaatgag ctgggcggcc tcccgcgtga cactctgcat ctgcaggaga 35280 gcgttcacgt acccgtcctg ggcacttagc gcaaagagcc gggggattag cgtaaggatg 35340 atggtggttc cctccgtgat cgagtaaacc atgttaagga ccagcgatcg cagctcggcg 35400 tttacggggc cgagttgttg gacgtccgcc agcagcgaga ggcgactccc gttgtagtac 35460 agcacgttga ggtctggcag ccctccgggg tttctggggc tggggttcag gtcccggatg 35520 cccctggcca cgagccgcgc cacgatttcg cgcgccaggg gcgatggaag cggaacggga 35580 aaccgcaacg tgaggtccag cgaatccagg cgcacgtccg tcgcttggcc ctcgaacacg 35640 ggcgggacga ggctgatggg gtccccgtta cagagatcta cgggggaggt gttgcgaagg 35700 ttaacggtgc cggcgtgggt gaggcccacg tccagggggc aggcgacgat tcgcgtggga 35760 agcacccggg tgatgaccgc ggggaagcgc cttcggtacg ccagcaacag ccccaacgtg 35820 tcgggactga cgcctccgga gacgaaggat tcgtgcgcca cgtcggccag cgtcagttgc 35880 cggcggatgg tcggcaggaa taccacccgc ccttcgcagc gctgcagcgc cgccgcatcg 35940 gggcgcgaga tgcccgaggg tatcgcgatg tcagtttcaa agccgtccgc cagcatggcg 36000 ccgatccacg cggcagggag tgcagtggtg gttcgggtgg cgggaggagc gcggtggggg 36060 tcagcggcgt agcagagacg ggcgaccaac ctcgcatagg acggggggtg ggtcttaggg 36120 ggttgggagg cgacagggac cccagagcat gcgcggggag gtctgtcggg cccagacgca 36180 ccgagagcga atccgtccat ggagtcccgg cctgggtttt atggggcccg gccctcggaa 36240 tcgcggcttg tcggcgggga caaagggggc ggggctaggg ggcttgcgga aacagaagac 36300 gtgtgggata aaagaatcgc actaccccaa ggaagggcgg ggcggtttat tacagagcca 36360 gtcccttgag cggggatgcg tcatagacga gatactgcgc gaagtgggtc tcccgcgcgt 36420 gggcttcccc gttgcgggcg ctgcggagga gggcggggtc gctggcgcag gtgagcgggt 36480 aggcctcctg aaacaggcca cacgggtcct ccacgagttc gcggcacccc ggggggcgct 36540 taaactgtac gtcgctggcg gcggtggccg tggacaccgc cgaacccgtc tccacgatca 36600 ggcgctccag gcagcgatgt ttggcggcga tgtcggccga cgtaaagaac ttaaagcagg 36660 ggctgagcac cggcgaggcc ccgttgaggt ggtaggcccc gttatagagc aggtccccgt 36720 acgaaaatcg ctgcgacgcc cacgggttgg ccgtggccgc gaaggcccgg gacgggtcgc 36780 tctggccgtg gtcgtacatg agggcggtga catccccctc cttgtccccc gcgtaaacgc 36840 ccccggcggc gcgtccccgg gggttgcagg gccggcggaa gtagttgacg tcggtcgaca 36900 cgggggtggc gataaactca cacacggcgt cctggccgtg gtccatccct gcgcgccgcg 36960 gcacctgggc gcacccgaac acggggacgg gctgggccgg ccccaggcgg tttcccgcca 37020 cgaccgcgtt ccgcaggtac acggctgccg cgttgtccag tagaggggga gccccgcggc 37080 ccaggtaaaa gttttgggga aggttgccca tgtcggtgac ggggttgcgg acggttgccg 37 140 tggccacgac ggcggtgtag cccacgccca ggtccacgtt cccgcgcggc tgggtgagcg 37200 tgaagtttac ccccccgcca gtttcatgcc gggccacctg gagctggccc aggaagtacg 37260 cctccgacgc gcgctccgag aacagcacgt tctcagtcac aaagcggtcc tgtcggacga 37320 cggtgaaccc aaacccggga tggaggcccg tcttgagctg atgatgcaag gccacgggac 37380 tgatcttgaa gtaccccgcc atgagcgcgt aggtcagcgc gttctccccg gccgcgctct 37440 cgcggacgtg ctgcacgacg ggctgtcgga tcgacgaaaa gtagttggcc cccagagccg 37500 gggggaccag ggggacctgc cgcgacaggt cgcgcagggc cggggggaaa ttgggcgcgt 37560 tcgccacgtg gtcggccccg gcgaacagcg cgtggacggg gagggggtaa aaatagtcgc 37620 cattttggat ggtatggtcc agatgctggg gggccatcag caggattccg gcgtgcaacg 37680 ccccgtcgaa tatgcgcatg ttggtggtgg acgcggtgtt ggcgcccgcg tcgggcgccg 37740 ccgagcagag cagcgccgtt gtgcgttcgg ccatgttgtg ggccagcacc tgcagcgtga 37800 gcatggcggg cccgtccact accacgcgcc cgttgtgaaa catggcgttg accgtgttgg 37860 ccaccagatt ggccgggtgc agggggtgcg cggggtccgt cacggggtcg ctggggcaat 37920 cctcgccggg ggtgatctcc gggaccacca tgttctgcag ggtggcgtat acgcggtcga 37980 agcgaacccc cgcggtgcag cagcggcccc gcgagaaggc gggcaccatc acgtagtagt 38040 aaatcttgtg gtgcacggtc cagtccgccc cccggtgcgg ccggtcgtcc gcggcgtccg 38 100 cggctcgggc ctgggtgttg tgcagcagct ggccgtcgtt gcggttgaag tccgcggtcg 38 160 ccacgttaca cgccgctgcg tacacggggt cgtggccccc cgcgctaacc cggcagtcgc 38220 gatggcggtc cagggccgcg cgccgcatca gggcgtcgca gtcccacacg aggggtggca 38280 gcagcgccgg gtctcgcatt aggtgattca gttcggcttg cgcctgcccg cccagttccg 38340 ggccggtcag ggtaaagtca tcaaccagct gggccagggc ctcgacgtgc gccaccaggt 38400 cccggtacac ggccatgcac tcctcgggaa ggtctccccc gaggtaggtc acgacgtacg 38460 agaccagcga gtagtcgttc acgaacgccg cgcaccgcgt gttgttccag tagctggtga 38520 tgcactggac cacgagccgg gccagggcgc agaagacgtg ctcgctgccg tgtatggcgg 38580 cctgcagcag gtaaaacacc gccgggtagt tgcggtcttc gaacgccccg cgaacggcgg 38640 cgatggtggc gggggccatg gcgtggcgtc ccacccccag ctccaggccc cgggcgtccc 38700 ggaacgccgc cggacatagc gccaggggca agttgccgtt caccacgcgc caggtggcct 38760 ggatctcccc cgggccggcc gggggaacgt ccccccccgg cagctccacg tcggccaccc 38820 ccacgaagaa gtcgaacgcg gggtgcagct caagagccag gttggcgttg tcgggctgca 38880 taaactgctc cggggtcatc tggccttccg cgacccatcg gacccgcccg tgggccaggc 38940 gctgccccca ggcgttcaaa aacagctgct gcatgtctgc ggcggggccg gccggggccg 39000 ccacgtacgc cccgtacgga ttggcggctt cgacggggtc gcggttaagg cccccgaccg 39060 ccgcgtcaac gttcatcagc gaagggtggc acacggtccc gatcgcgtgt tccagagaca 39120 ggcgcagcac ctggcggtcc ttcccccaaa aaaacagctg gcggggcggg aaggcgcggg 39180 gatccgggtg gccgggggcg gggactaggt ccccggcgtg cgcggcaaac cgttccatga 39240 ccggattgaa caggcccagg ggcaggacga acgtcaggtc catggcgccc accagggggt 39300 agggaacgtt ggtggcggcg tagatgcgct tctccagggc ctccaaaaag atcagcttct 39360 cgccgatgga caccagatcc gcgcgcacgc gcgtcgtctg gggggcgctc tcgagctcgt 39420 ccagcgtctg ccggttcagg tcgagctgct cctcctgcat ctccagcagg tggcggccca 39480 cgtcgtccag acttcgcacg gccttgccca tcacgagcgc cgtgaccagg ttggccccgt 39540 tcaggaccat ctcgccgtac gtcaccggca cgtcggcttc ggtgtcctcc actttcagga 39600 aggactgcag gaggcgctgt ttgatcgggg cggtggtgac gagcaccccg tcgaccggac 39660 gcccgcgcgt gtcggcatgc gtcagacggg gcacggccac ggagggctgc gtggccgtgg 39720 tgaggtccac gagccaggcc tcgacggcct cccggcggtg gcccgccttg cccaggaaaa 39780 agctcgtctc gcagaagctt cgctttagct cggcgaccag ggtcgcccgg gccaccctgg 39840 tggccaggcg gccgttgtcc aggtatcgtt gcatcggcaa caacaaagcc aggggcggcg 39900 ccttttccag cagcacgtgc agcatctggt cggccgtgcc gcgctcaaac gccccgagga 39960 cggcctggac gttgcgagcg agctgttgga tggcgcgcaa ctggcgatgc gcgctgatac 40020 ccgtcccgtc cagggcctcc cccgtgagca gggcgatggc ctcggtggcc aggctgaagg 40080 cggcgttcag ggcccggcgg tcgataatct tggtcatgta attgtgtgtg ggttgctcga 40140 tggggtgcgg gccgtcgcgg gcaatcagcg gctggtggac ctcgaactgt acgcgcccct 40200 cgttcatgta ggccagctcc ggaaacttgg tacacacgca cgccaccgac aacccgagct 40260 ccagaaagcg cacgagcgac agggtgttgc aatacgaccc caacagggcg tcgaactcga 40320 cgtcatacag gctgtttgca tcggagcgca cgcgggaaaa aaaatcgaac aggcgtcgat 40380 gcgacgccac ctcgatcgtg ctaaggaggg acccggtcgg caccatggcc gcggcatacc 40440 ggtatcccgg agggtcgcgg ttgggagcgg ccatggggtc gcgtggagat cggctgtctc 40500 tagcgatatt ggcccgggga ggctaagatc caccccaacg cccggccacc cgtgtacgtg 40560 cccgacggcc caaggtccac cgaaagacac gacgggcccg gacccaaaaa ggcgggggat 40620 gctgtgtgag aggccgggtg tcggtcgggg gggaaaggca ccgggagaag gctgcggcct 40680 cgttccagga gaacccagtg tccccaacag acccggggac gtgggatccc aggccttata 40740 tacccccccc gccccacccc cgttagaacg cgacgggtgc attcaagatg gccctggtcc 40800 aaaagcgtgc caggaagaaa ttggcagagg cggcaaagct gtccgccgcc gccacccaca 40860 tcgaggcccc ggccgcgcag gctatcccca gggcccgtgt gcgcagggga tcggtgggcg 40920 gcagcatttg gttggtggcg ataaagtgga aaagcccgtc cggactgaag gtctcgtggg 40980 cggcggcgaa caaggcacac agggccgtgc ctcccaaaaa cacggacatc ccccaaaaca 41040 cgggcgccga caacggcaga cgatccctct tgatgttaac gtacaggagg agcgcccgca 41100 ccgcccacgt aacgtagtag ccgacgatgg cggccaggat acaggccggc gccaccaccc 41160 ttccggtcag cccgtaatac atgcccgctg ccaccatctc caacggcttc aggaccaaaa 41220 acgaccaaag gaacagaatc acgcgctttg aaaagaccgg ctgggtatgg ggcggaagac 41280 gcgagtatgc cgaactgaca aaaaagtcag aggtgccgta cgaggacaat gaaaactgtt 41340 cctccagtgg cagttctccc tcctcccccc caaaggcggc ctcgtcgacc agatctcgat 41400 ccaccagagg aaggtcatcc cgcatggtca tggggtgtgc ggtggaggtg gggagaccga 41460 aaccgcaaag ggtcgcttac gtcagcagga tcccgagatc aaagacaccc gggttcttgc 41520 acaaacacca cccgggttgc atccgcggag gcgagtgttt tgataaggcc gttccgcgcc 41580 ttgatataac ctttgatgtt gaccacaaaa cccggaattt acgcctacgc cccaatgccc 41640 acgcaagatg aggtaggtaa cccccccccc gtgggtgtga cgttgcgttt agttcattgg 41700 aggccaaggg gaaaatgggg tggggaggaa acggaaaacc cagtaggccg tgttgggaac 41760 acgcccgggg ttgtcctcaa aaggcagggt ccatactacg gaagccgtcg ttgtattcga 41820 gacctgcctg tgcgacgcac gtcggggttg cctgtgtccg gttcggcccc accgcgtgcg 41880 gcacgcacga ggacgagtcc gcgtgcttta ttggcgttcc aagcgttgcc ctccagtttc 41940 tgttgtcggt gttcccccat acccacgccc acatccaccg tagggggcct ctgggccgtg 42000 tcacgtcgcc gcccgcgatg gagcttagct acgccaccac catgcactac cgggacgttg 42060 tgttttacgt cacaacggac cgaaaccggg cctactttgt gtgcgggggg tgtgtttatt 42120 ccgtggggcg gccgtgtgcc tcgcagcccg gggagattgc caagtttggt ctggtcgttc 42180 gagggacagg cccagacgac cgcgtggtcg ccaactatgt acgaagcgag ctccgacaac 42240 gcggcctgca ggacgtgcgt cccattgggg aggacgaggt gtttctggac agcgtgtgtc 42300 ttctaaaccc gaacgtgagc tccgagctgg atgtgattaa cacgaacgac gtggaagtgc 42360 tggacgaatg tctggccgag tactgcacct cgctgcgaac cagcccgggt gtgctaatat 42420 ccgggctgcg cgtgcgggcg caggacagaa tcatcgagtt gtttgaacac ccaacgatag 42480 tcaacgtttc ctcgcacttt gtgtataccc cgtccccata cgtgttcgcc ctggcccagg 42540 cgcacctccc ccggctcccg agctcgctgg aggccctggt gagcggcctg tttgacggca 42600 tccccgcccc acgccagcca cttgacgccc acaacccgcg cacggatgtg gttatcacgg 42660 gccgccgcgc cccacgaccc atcgccgggt cgggggcggg gtcggggggc gcgggcgcca 42720 agcgggccac cgtcagcgag ttcgtgcaag tcaaacacat tgaccgcgtg ggccccgctg 42780 gcgtttcgcc ggcgcctccg ccaaacaaca ccgactcaag ttccctggtg cccggggccc 42840 aggattccgc cccgcccggc cccacgctaa gggagctgtg gtgggtgttt tatgccgcag 42900 accgggcgct ggaggagccc cgcgccgact ctggcctcac ccgcgaggag gtacgtgccg 42960 tacgtgggtt ccgggagcag gcgtggaaac tgtttggctc cgcgggggcc ccgcgggcgt 43020 ttatcggggc cgcgttgggc ctgagccccc tccaaaagct agccgtttac tactatatca 43080 tccaccgaga gaggcgcctg tcccccttcc ccgcgctagt ccggctcgta ggccggtaca 43 140 cacagcgcca cggcctgtac gtccctcggc ccgacgaccc agtcttggcc gatgccatca 43200 acgggctgtt tcgcgacgcg ctggcggccg gaaccacagc cgagcagctc ctcatgttcg 43260 accttctccc cccaaaggac gtgccggtgg gaagcgacgt gcaggccgac agcaccgctc 43320 tgctgcgctt tatagaatcg caacgtctcg ccgtccccgg gggggtgatc tcccccgagc 43380 acgtcgcgta ccttggtgcg ttcctgagcg tgctgtacgc tggccgcggg cgcatgtccg 43440 cagccacgca caccgcgcgg ctgacagggg tgacctccct ggtgctagcg gtgggtgacg 43500 tggaccgtct ttccgcgttt gaccgcggag cggcgggcgc ggccagccgc acgcgggccg 43560 ccgggtacct ggatgtgctt cttaccgttc gtctcgctcg ctcccaacac ggacagtctg 43620 tgtaacagac cccaataaac gtatgtcgct accacaccct tgtgtgtcaa tggacgcctc 43680 tccggggggg aagggaaaac aaagaggggc tgggggagcg gcaccaccgg ggcctgaaca 43740 aacaaaccac agacacggtt acagtttatt cggtcgggcg gagaaacggc cgaagccacg 43800 ccccctttat tcgcgtctcc aaaaaaacgg gacacttgtc cggagaacct ttaggatgcc 43860 agccagggcg gcggtaatca taaccacgcc cagcgcagag gcggccagaa acccgggcgc 43920 aattgcggcc acgggctgcg tgtcaaaggc tagcaaatga atgacggttc cgtttggaaa 43980 tagcaacaag gccgtggacg gcacgtcgct cgaaaacacg cttggggcgc cctccgtcgg 44040 cccggcggcg atttgctgct gtgtgttgtc cgtatccacc agcaacacag acatgacctc 44100 cccggccggg gtgtagcgca taaacacggc ccccacgagc cccaggtcgc gctggttttg 44160 ggtgcgcacc agccgcttgg actcgatatc ccgggtggag ccttcgcatg tcgcggtgag 44220 gtaggttagg aacagtgggc gtcggacgtc gacgccggtg agcttgtagc cgatcccccg 44280 gggcagaggg gagtgggtga cgacgtagct ggcgttgtgg gtgatgggta ccaggatccg 44340 tggctcgacg ttggcagact gccccccgca ccgatgtgag gcctcaggga cgaaggcgcg 44400 gatcagggcg ttgtagtgtg cccagcgcgt cagggtcgag gcgaggccgt gggtctgctg 44460 ggccaggact tcgaccgggg tctcggatcg ggtggcttga gccagcgcgt ccaggataaa 44520 cacgctctcg tctagatcaa agcgcaggga ggccgcgcat ggcgaaaagt ggtccggaag 44580 ccaaaagagg gttttctggt ggtcggcccg ggccagcgcg gtccggaggt cggcgttggt 44640 cgctgcggcg acgtcggacg tacacagggc cgaggctatc agaaggctcc ggcgggcgcg 44700 ttcccgctgc accgccgagg ggacgcccgc caagaacggc tgccggagga cagccgaggc 44760 gtaaaatagc gcccggtgga cgaccggggt ggtcagcacg cggcccccta gaaactcggc 44820 atacagggcg tcgatgagat gggctgcgct gggcgccact gcgtcgtacg ccgaggggct 44880 atccagcacg aaggccagct gatagcccag cgcgtgtaat gccaagctct gttcgcgctc 44940 cagaatctcg gccaccaggt gctggagccg agcctctagc tgcaggcggg ccgtgggatc 45000 caagactgac acattaaaaa acacagaatc cgcggcacag cccgcggccc cgcgggcggc 45060 caacccggca agcgcgcgcg agtgggccaa aaagcctagc aggtcggaga ggcagaccgc 45120 gccgtttgcg tgggcggcgt tcacgaaagc aaaacccgac gtcgcgagca gccccgttag 45180 gcgccagaag agagggggac gcgggccctg ctcggcgccc gcgtcccccg agaaaaactc 45240 cgcgtatgcc cgcgacagga actgggcgta gttcgtgccc tcctccgggt agccgcccac 45300 gcggcggagg gcgtccagcg cggagccgtt gtcggcccgc gtcagggacc ctaggacaaa 45360 gacccgatac cgggggccgc ccgggggccc gggaagagcc cccggggggt tttcgtccgc 45420 ggggtccccg acccgatcta gcgtctggcc cgcggggacc accatcactt ccaccggagg 45480 gctgtcgtgc atggatatca cgagccccat gaattcccgc ccgtagcgcg cgcgcaccag 45540 cgcggcatcg cacccgagca ccagctcccc cgtcgtccag atgcccacgg gccacgtcga 45600 ggccgacggg gagaaataca cgtacctacc tggggatctc aacaggcccc gggtggccaa 45660 ccaggtcgtg gacgcgttgt gcaggtgcgt gatgtccagc tccgtcgtcg ggtgccgccg 45720 ggccccaacc ggcggtcggg ggggcggtgt atcacgcggc ccgctcgggt ggctcgccgt 45780 cgccacgttg tctccccgcg ggaacgtcag ggcctcgggg tcagggacgg ccgaaaacgt 45840 tacccaggcc cgggaacgca gcaacacgga ggcggttgga ttgtgcaaga gacccttaag 45900 gggggcgacc gcggggggag gctgggcggt cggctcgacc gtgatggggg cgggcaggct 45960 cgcgttcggg ggccggccga gcaggtaggt cttcgagatg taaagcagct ggccggggtc 46020 ccgcggaaac tcggccgtgg tgaccaatac aaaacaaaag cgctcctcgt accagcgaag 46080 aaggggcaga gatgccgtag tcaggtttag ttcgtccggc ggcgccagaa atccgcgcgg 46140 tggtttttgg gggtcggggg tgtttggcag ccacagacgc ccggtgttcg tgtcgcgcca 46200 gtacatgcgg tccatgccca ggccatccaa aaaccatggg tctgtctgct cagtccagtc 46260 gtggacctga ccccacgcaa cgcccaaaag aataaccccc acgaaccata aaccattccc 46320 catgggggac cccgtcccta acccacgggg cccgtggcta tggcagggct tgccgccccg 46380 acgttggctg cgagccctgg gccttcaccc gaacttgggg gttggggtgg ggaaaaggaa 46440 gaaacgcggg cgtattggcc ccaatggggt ctcggtgggg tatcgacaga gtgccagccc 46500 tgggaccgaa ccccgcgttt atgaacaaac gacccaacac ccgtgcgttt tattctgtct 46560 ttttatttcc gtcatagcgc gggttccttc cggtattgtc tccttccgtg tttcagttag 46620 cctcccccat ctcccgggca aacgtgcgcg ccaggtcgca gatcgtcggt atggagcctg 46680 gggtggtgac gtgggtctgg accatcccgg aggtaagttg cagcagggcg tcccggcagc 46740 cggcgggcga ttggtcgtaa tccaggataa agacgtgcat gggacggagg cgtttggcca 46800 agacgtccaa ggcccaggca aacacgttat acaggtcgcc gttgggggcc agcaactcgg 46860 gggcccgaaa cagggtaaat aacgtgtccc cgatatgggg tcgtgggccc gcgttgctct 46920 ggggctcggc accctggggc ggcacggccg tccccgaaag ctgtccccaa tcctcccgcc 46980 acgacccgcc gccctgcaga taccgcaccg tattggcaag cagcccgtaa acgcggcgaa 47040 tcgcggccaa catagccagg tcaagccgct cgccggggcg ctggcgtttg gccaggcggt 47 100 cgatgtgtct gtcctccgga agggccccca acacgatgtt tgtgccgggc aaggtcggcg 47 160 ggatgagggc cacgaacgcc agcacggcct ggggggtcat gctgcccata aggtatcgcg 47220 cggccgggta gcacaggagg gcggcgatgg gatggcggtc gaagatgagg gtgagggccg 47280 ggggcggggc atgtgagctc ccagcctccc ccccgatatg aggagccaga acggcgtcgg 47340 tcacggcata aggcatgccc attgttatct gggcgcttgt cattaccacc gccgcgtccc 47400 cggccgatat ctcaccctgg tcgaggcggt gttgtgtggt gtagatgttc gcgattgtct 47460 cggaagcccc cagcacctgc cagtaagtca tcggctcggg tacgtagacg atatcgtcgc 47520 gcgaacccag ggccaccagc agttgcgtgg tggtggtttt ccccatcccg tgaggaccgt 47580 ctatataaac ccgcagtagc gtgggcattt tctgctccag gcggacttcc gtggcttctt 47640 gctgccggcg agggcgcaac gccgtacgtc ggttgctatg gccgcgagaa cgcgcagcct 47700 ggtcgaacgc agacgcgtgt tgatggcagg ggtacgaagc catacgcgct tctacaaggc 47760 gcttgccaaa gaggtgcggg agtttcacgc caccaagatc tgcggcacgc tgttgacgct 47820 gttaagcggg tcgctgcagg gtcgctcggt gttcgaggcc acacgcgtca ccttaatatg 47880 cgaagtggac ctgggaccgc gccgccccga ctgcatctgc gtgttcgaat tcgccaatga 47940 caagacgctg ggcggggttt gtgtcatcat agaactaaag acatgcaaat atatttcttc 48000 cggggacacc gccagcaaac gcgagcaacg ggccacgggg atgaagcagc tgcgccactc 48060 cctgaagctc ctgcagtccc tcgcgcctcc gggtgacaag atagtgtacc tgtgccccgt 48120 cctggtgttt gtcgcccaac ggacgctccg cgtcagccgc gtgacccggc tcgtcccgca 48180 gaaggtctcc ggtaatatca ccgcagtcgt gcggatgctc cagagcctgt ccacgtatac 48240 ggtccccatg gagcctagga cccagcgagc ccgtcgccgc cgcggcggcg ctgcccgggg 48300 gtctgcgagc agaccgaaaa ggtcacactc tggggcgcgc gacccgcccg agccagcggc 48360 ccgccaggta ccacccgccg accaaacccc cgcctccacg gagggcgggg gggtgcttaa 48420 gaggatcgcg gcgctcttct gcgtgcccgt ggccaccaag accaaacccc gagctgcctc 48480 cgaatgagag tgtttcgttc cttccccctc cccccgcgtc agacaaaccc taaccaccgc 48540 ttaagcggcc cccgcgaggt ccgaagactc atttggatcc ggcgggagcc acctgacaac 48600 agcccccggg tttccccacg ccagacgccg gtccgctgtg ccatcgctcc ccttcatccc 48660 acccccatct tgtccccaaa taaaacaagg tctggtagtt aggacaacga ccgcagttct 48720 cgtgtgttat tgtcgctctc cgcctctcgc agatggaccc gtattgccca tttgacgctc 48780 tggacgtctg ggaacacagg cgcttcatag tcgccgattc ccgaaacttc atcacccccg 48840 agttcccccg ggacttttgg atgtcgcccg tctttaacct cccccgggag acggcggcgg 48900 agcaggtggt cgtcctgcag gcccagcgca cagcggctgc cgctgccctg gagaacgccg 48960 ccatgcaggc ggccgagctc cccgtcgata tcgagcgccg gttacgcccg atcgaacgga 49020 acgtgcacga gatcgcaggc gccctggagg cgctggagac ggcggcggcc gccgccgaag 49080 aggcggatgc cgcgcgcggg gatgagccgg cgggtggggg cgacgggggg gcgcccccgg 49140 gtctggccgt cgcggagatg gaggtccaga tcgtgcgcaa cgacccgccg ctacgatacg 49200 acaccaacct ccccgtggat ctgctacata tggtgtacgc gggccgcggg gcgaccggct 49260 cgtcgggggt ggtgttcggg acctggtacc gcactatcca ggaccgcacc atcacggact 49320 ttcccctgac cacccgcagt gccgactttc gggacggccg gatgtccaag accttcatga 49380 cggcgctggt cctgtccctg cagtcgtgcg gccggctgta tgtgggccag cgccactatt 49440 ccgccttcga gtgcgccgtg ttgtgtctct acctgctgta ccgaaacacg cacggggccg 49500 ccgacgatag cgaccgcgct ccggtcacgt tcggggatct gctgggccgg ctgccccgct 49560 acctggcgtg cctggccgcg gtgatcggga ccgagggcgg ccggccacag taccgctacc 49620 gcgacgacaa gctccccaag acgcagttcg cggccggcgg gggccgctac gaacacggag 49680 cgctggcgtc gcacatcgtg atcgccacgc tgatgcacca cggggtgctc ccggcggccc 49740 cgggggacgt cccccgggac gcgagcaccc acgttaaccc cgacggcgtg gcgcaccacg 49800 acgacataaa ccgcgccgcc gccgcgttcc tcagccgggg ccacaaccta ttcctgtggg 49860 aggaccagac tctgctgcgg gcaaccgcga acaccataac ggccctgggc gttatccagc 49920 ggctcctcgc gaacggcaac gtgtacgcgg accgcctcaa caaccgcctg cagctgggca 49980 tgctgatccc cggagccgtc ccttcggagg ccatcgcccg tggggcctcc gggtccgact 50040 cgggggccat caagagcgga gacaacaatc tggaggcgct atgtgccaat tacgtgcttc 50 100 cgctgtaccg ggccgacccg gcggtcgagc tgacccagct gtttcccggc ctggccgccc 50 160 tgtgtcttga cgcccaggcg gggcggccgg tcgggtcgac gcggcgggtg gtggatatgt 50 220 catcgggggc ccgccaggcg gcgctggtgc gcctcaccgc cctggaactc atcaaccgca 50280 cccgcacaaa ccccaccccc gtgggggagg ttatccacgc ccacgacgcc ctggcgatcc 50340 aatacgaaca ggggcttggc ctgctggcgc agcaggcacg cattggcttg ggctccaaca 50400 ccaagcgttt ctccgcgttc aacgttagca gcgactacga catgttgtac tttttatgtc 50460 tggggttcat tccacagtac ctgtcggcgg tttagtgggt ggtgggcgag gggggagggg 50520 gcattaggga gaaagaacaa gagcctccgt tgggttttct ttgtgcctgt actcaaaagg 50580 tcataccccg taaacggcgg gctccagtcc cggcccggcg gttggcgtga acgcaacggc 50640 gggagctggg ttagcgttta gtttagcatt cgctctcgcc tttccgcccg cccccgaccg 50700 ttgagccttt ttttttttcg tccaccaaag tctctgtggg tgcgcgcatg gcagccgatg 50760 ccccgggaga ccggatggag gagcccctgc cagacagggc cgtgcccatt tacgtggctg 50820 ggtttttggc cctgtatgac agcggggact cgggcgagtt ggcattggat ccggatacgg 50880 tgcgggcggc cctgcctccg gataacccac tcccgattaa cgtggaccac cgcgctggct 50940 gcgaggtggg gcgggtgctg gccgtggtcg acgacccccg cgggccgttt tttgtgggac 51000 tgatcgcctg cgtgcaactg gagcgcgtcc tcgagacggc cgccagcgct gcgattttcg 51060 agcgccgcgg gccgccgctc tcccgggagg agcgcctgtt gtacctgatc accaactacc 51120 tgccctcggt ctccctggcc acaaaacgcc tggggggcga ggcgcacccc gatcgcacgc 51180 tgttcgcgca cgtagcgctg tgcgcgatcg ggcggcgcct tggcactatc gtcacctacg 51240 acaccggtct cgacgccgcc atcgcgccct ttcgccacct gtcgccggcg tctcgcgagg 51300 gggcgcggcg actggccgcc gaggccgagc tcgcgctatc cggacgcacc tgggcgcccg 51360 gcgtggaggc gctgacccac acgctgcttt ccaccgccgt taacaacatg atgctgcggg 51420 accgctggag cctggtggcc gagcggcggc ggcaggccgg gatcgccgga cacacctacc 51480 tccaggcgag cgaaaaattc aaaatgtggg gggcggagcc tgtttccgcg ccggcgcgcg 51540 ggtataagaa cggggccccg gagtccacgg acataccgcc cggctcgatc gctgccgcgc 51600 cgcagggtga ccggtgccca atcgtccgtc agcgcggggt cgcctcgccc ccggtactgc 51660 cccccatgaa ccccgttcca acatcgggca ccccggcccc cgcgccgccc ggcgacggga 51720 gctacctgtg gatcccggcc tcccattaca accagctcgt cgccggccac gccgcgcccc 51780 aaccccagcc gcattccgcg tttggtttcc cggctgcggc gggggccgtg gcctatgggc 51840 ctcacggcgc gggtctttcc cagcattacc ctccccacgt cgcccatcag tatcccgggg 51900 tgctgttctc gggacccagc ccactcgagg cgcagatagc cgcgttggtg ggggccatag 51960 ccgcggaccg ccaggcgggc ggtcagccgg ccgcgggaga ccctggggtc cgggggtcgg 52020 gaaagcgtcg ccggtacgag gcggggccgt cggagtccta ctgcgaccag gacgaaccgg 52080 acgcggacta cccgtactac cccggggagg ctcgaggcgg gccgcgcggg gtcgactctc 52140 ggcgcgcggc ccgccagtct cccgggacca acgagaccat cacggcgctg atgggggcgg 52200 tgacgtctct gcagcaggaa ctggcgcaca tgcgggctcg gaccagcgcc ccctatggaa 52260 tgtacacgcc ggtggcgcac tatcgccctc aggtggggga gccggaacca acaacgaccc 52320 acccggccct ttgtcccccg gaggccgtgt atcgcccccc accacacagc gccccctacg 52380 gtcctcccca gggtccggcg tcccatgccc ccactccccc gtatgcccca gctgcctgcc 52440 cgccaggccc gccaccgccc ccatgtcctt ccacccagac gcgcgcccct ctaccgacgg 52500 agcccgcgtt cccccccgcc gccaccggat cccaaccgga ggcatccaac gcggaggccg 52560 gggcccttgt caacgccagc agcgcagcac acgtggacgt tgacacggcc cgcgccgccg 52620 atttgttcgt ctctcagatg atgggggccc gctgattcgc cccggtcttt ggtaccatgg 52680 gatgtcttac tgtatatctt tttaaataaa ccaggtaata ccaaataaga cccattggtg 52740 tatgttcttt ttttattggg aggggcgggt aggcgggtag ctttacaatg caaaagcctt 52800 tgacgtggag gaaggcgtgg gggggaggaa atcggcactg accaaggggg tccgttttgt 52860 cacgggaaag gaaagaggaa acaggccgcg gacacccggg ggagtttatg tgttcctttt 52920 tctttcttcc cacacacaca caaaaggcgt accaaacaaa aaaaccaaaa gatgcgcatg 52980 cggtttaaca cccgtggttt ttatttacaa caaacccccc gtcacaggtc gtcctcgtcg 53040 gcgtcaccgt ctttgttggg aacttgggtg tagttggtgt tgcggcgctt gcgcatgacc 53100 atgtcggtga ccttggcgct gagcagcgcg ctcgtgccct tcttcttggc cttgtgttcc 53160 gtgcgctcca tggccgacac cagggccatg taccgtatca tctccctggc ctcggctagc 53220 ttggcctcgt caaagtcgcc gccctcctcg ccctccccgg acgcgtccgg gttggtgggg 53280 ttcttgagct ccttggtggt tagagggtac agggccttca tggggttgct ctgcagccgc 53340 atgacgtaac gaaaggcgaa gaaggccgcc gccaggccgg ccaggaccaa cagacccacg 53400 gccagcgccc caaaggggtt ggacatgaag gaggacacgc ccgacacggc cgataccacg 53460 ccgcccacga tgcccatcac caccttgccg accgcgcgcc ccaggtcgcc catcccctcg 53520 aagaacgcgc ccaggcccgc gaacatggcg gcgttggcgt cggcgtggat gaccgtgtcg 53580 atgtcggcga agcgcaggtc gtgcagctgg ttgcggcgct ggacctccgt gtagtccagc 53640 aggccgctgt ccttgatctc gtggcgggtg tacacctcca gggggacaaa ctcgtgatcc 53700 tccagcatgg tgatgttgag gtcgatgaag gtgctgacgg tggtgatgtc ggcgcggctc 53760 agctggtggg agtacgcgta ctcctcgaag tacacgtagc ccccaccgaa ggtgaagtag 53820 cgccggtgtc ccacggtgca cggctcgatc gcatcgcgcg tcagccgcag ctcgttgttc 53880 tcccccagct gcccctcgac caacgggccc tggtcttcgt accgaaagct gaccaggggg 53940 cggctgtagc aggccccggg ccgcgagctg atgcgcatcg agttttggac gatcacgttg 54000 tccgcggcga ccggcacgca cgtggagacg gccatcacgt cgccgagcat ccgcgcgctc 54060 acccgccggc ccacggtgac cgaggcgatg gcgttggggt tcagcttgcg ggcctcgttc 54120 cacagggtca gctcgtgatt ctgtagctcg caccacgcga tggcaacgcg gcccaacata 54180 tcgttgacat ggcgctgtat gtggttgtac gtaaactgca gccgggcgaa ctcgatggag 54240 gaggtggtct tgatgcgctc cacggacgcg ttggcgctgg ccccgggcgg cgggggcgtg 54300 gggtttgggg gcttgcggct ctgctctcgg aggtgttccc gcacgtacag ctccgcgagc 54360 gtgttgctga gaaggggctg gtacgcgatc agaaagcccc cattggccag gtagtactgc 54420 ggctggccca ccttgatgtg cgtcgcgttg tacctgcggg cgaagatgcg gtccatggcg 54480 tcgcgggcgt ccttgccgat gcagtccccc aggtccacgc gcgagagcgg gtactcggtc 54540 aggttggtgg tgaaggtggt ggatatggcg tcggaggaga atcggaagga gccgccgtac 54600 tcggagcgca gcatctcgtc cacttcctgc cacttggtca tggtgcagac cgacgggcgc 54660 tttggcaccc agtcccaggc cacggtgaac ttgggggtcg tgagcaggtt ccgggtggtc 54720 ggcgccgtgg cccgggcctt ggtggtgagg tcgcgcgcgt agaagccgtc gacctgcttg 54780 aagcggtcgg cggcgtagct ggtgtgttcg gtgtgcgacc cctcccggta gccgtaaaac 54840 ggggacatgt acacaaagtc gccagtcgcc agcacaaact cgtcgtacgg gtacaccgag 54900 cgcgcgtcca cctcctcgac gatgcagttt accgtcgtcc cgtaccggtg gaacgcctcc 54960 acccgcgagg ggttgtactt gaggtcggtg gtgtgccagc cccggctcgt gcgggtcgcg 55020 gcgttggccg gtttcagctc catgtcggtc tcgtggtcgt cccggtgaaa cgcggtggtc 55080 tccaggttgt tgcgcacgta cttggccgtg gaccgacaga cccccttggc gttgatcttg 55 140 tcgatcacct cctcgaaggg gacgggggcg cggtcctcaa agatccccat aaactgggag 55200 tagcggtggc cgaaccacac ctgcgaaacg gtgacgtctt tgtagtacat ggtggccttg 55260 aacttgtacg gggcgatgtt ctccttgaag accaccgcga tgccctccgt gtagttctga 55320 ccctcgggcc gggtcgggca gcggcgcggc tgctcgaact gcaccaccgt ggcgcccgtg 55380 gggggtgggc acacgtaaaa gtttgcatcg gtgttctccg ccttgatgtc ccgcaggtgc 55440 tcgcgcaggg tggcgtggcc cgcggcgacg gtcgcgttgt cgccggcggg gcgtggtggc 55500 gttgggtttt tcggtttttt gttcttcttc ggtttcgggt cccccgttgg ggcggcgcca 55560 agggcgggcg gcgccggagt ggcagggccc ccgttcgccg cctgggtcgc ggccgcgacc 55620 ccaggcgtgc cgggggaact cggagccgcc gacgccacca ggacccccag cgtcaacccc 55680 aagagcgccc atacgacgaa ccaccggcgc ccccacgagg gggcgccctg gtgcatggcg 55740 ggactacggg ggcccgtcgt gccccccgtc aggtagcctg ggggcgaggt gctggaggac 55800 cgagtagagg atcgagaaaa cgtcgcggtc gtagaccacg accgaccggg ggccgataca 55860 gccgtcgggg gcgctctcga cgatggccac cagcggacag tcggagtcgt acgtgagata 55920 tacgccgggc gggtaacggt aacgaccttc ggaggtcggg cggctgcagt ccgggcggcg 55980 caactcgagc tccccgcacc ggtagaccga ggcaaagagt gtggtggcga taatcagctc 56040 gcgaatatat cgccaggcgg cgcgctgagt gggcgttatt ccggaaatgc cgtcaaaaca 56100 gtaaaacctc tgaaattcgc tgacggccca atcagcaccc gagccccccg cccccatgat 56160 gaaccgggcg agctcctcct tcaggtgcgg caggagcccc acgttctcga cgctgtaata 56220 cagcgcggtg ttggggggct gggcgaagct gtgggtggag tgatcaaaga ggggcccgtt 56280 gacgagctcg aagaagcgat gggtgatgct ggggagcagg gccgggtcca cctggtgtcg 56340 caggagagac gctcgcatga accggtgcgc gtcgaacacg cccggcgccg agcggttgtc 56400 gatgaccgtg cccgcgcccg ccgtcagggc gcagaagcgc gcgcgcgccg caaagccgtt 56460 ggcgaccgcg gcgaacgtcg cgggcagcac ctcgccgtgg acgctgaccc gcagcatctt 56520 ctcgagctcc ccgcgctgct cgcggacgca gcgccccagg ctggccaacg accgcttcgt 56580 caggcggtcc gcgtacagcc gccgtcgctc ccgtacgtcc gcggccgctt gcgtggcgat 56640 gtccccccac gtctcgggcc cctgcccccc gggcccgcgg cgacggtctt cgtcctcgcc 56700 cccgcccccg ggagctccca acccccgtgc cccttcctct acggcgacac ggtccccgtc 56760 gtcgtcgggg cccgcgccgc ccttgggcgc gtccgccgcg ccccccgccc ccatgcgcgc 56820 cagcacgcga cgcagcgcct cctcgtcgca ctgttcgggg ctgacgaggc gccgcaagag 56880 cggcgtcgtc aggtggtggt cgtagcacgc gcggatgagc gcctcgatct gatcgtcggg 56940 tgacgtggcc tgaccgccga ttattagggc gtccaccata tccagcgccg ccaggtggct 57000 cccgaacgcg cgatcgaaat gctccgcccg ccgcccgaac agcgccagtt ccacggccac 57060 cgcggcggtc tcctgctgca actcgcgccg cgccagcgcg gtcaggttgc tggcaaacgc 57120 gtccatggtg gtctggccgg cgcggtcgcc ggacgcgagc cagaatcgca attcgctgat 57180 ggcgtacagg ccgggcgtgg tggcctgaaa cacgtcgtgc gcctccagca gggcgtcggc 57 240 ctccttgcgg accgagtcgt tctcgggcga cgggtggggc tgcccgtcgc cccccgcggt 57300 ccgggccagc gcatggtcca acacggagag cgcccgcgcg cggtcggcgt ccgacagccc 57360 ggcggcgtgg ggcaggtacc gccgcagctc gttggcgtcc agccgcacct gcgcctgctg 57420 ggtgacgtgg ttacagatac ggtccgccag gcggcgggcg atcgtcgccc cctggttcgc 57480 cgtcacacac agttcctcga aacagaccgc gcaggggtgg gacgggtcgc taagctccgg 57540 ggggacgata aggcccgacc ccaccgcccc caccataaac tcccgaacgc gctccagcgc 57600 ggcggtggcg ccgcgcgagg gggtgatgag gtggcagtag tttagctgct ttagaaagtt 57660 ctcgacgtcg tgcaggaaac acagctccat atggacggtc ccgccatacg tatccagcct 57720 gacccgttgg tgatacggac agggtcgggc caggcccatg gtctcggtga aaaacgccgc 57780 gacgtctccc gcggtcgcga acgtctccag gctgcccagg agccgctcgc cctcgcgcca 57840 cgcgtactct agcagcaact ccagggtgac cgacagcggg gtgagaaagg ccccggcctg 57900 ggcctccagg cccggcctca gacgacgccg cagcgcccgc acctgaagcg cgttcagctt 57960 cagttggggg agcttccccc gtccgatgtg ggggtcgcac cgccggagca gctctatctg 58020 aaacacatag gtctgcacct gcccgagcag ggctaacaac ttttgacggg ccacggtggg 58080 ctcggacacc ggggcggcca tctcgcggcg ccgatctgta ccgcggccgg agtatgcggt 58140 ggaccgaggc ggtccgtacg ctacccggtg tctggctgag ccccggggtc cccctcttcg 58200 gggcggcctc ccgcgggccc gccgaccggc aagccgggag tcggcggcgc gtgcgtttct 58260 gttctattcc cagacaccgc ggagaggaat cacggcccgc ccagagatat agacacggaa 58320 cacaaacaag cacggatgtc gtagcaataa tttattttac acacattccc cgccccgccc 58380 taggttcccc caccccccaa cccctcacag catatccaac gtcaggtctc cctttttgtc 58440 ggggggcccc tccccaaacg ggtcatcccc gtggaacgcc cgtttgcggc cggcaaatgc 58500 cggtcccggg gcccccgggc cgccgaacgg cgtcgcgttg tcgtcctcgc agccaaaatc 58560 cccaaagtta aacacctccc cggcgttgcc gagttggctg actagggcct cggcctcgtg 58620 cgccacctcc agggccgcgt ccgtcgacca ctcgccgttg ccgcgctcca gggcacgcgc 58680 ggtcagctcc atcatctcct cgcttaggta ctcgtcctcc aggagcgcca gccagtcctc 58740 gatctgcagc tgctgggtgc ggggccccag gcttttcacg gtcgccacga acacgctact 58800 ggcgacggcc gccccgccct cggagataat gccccggagc tgctcgcaca gcgagctttc 58860 gtgcgctccg ccgccgaggt tcgaggccgc gcacacaaac ccggcccggg gacaggccag 58920 gacgaacttg cgggtgcggt caaaaataag gagcgggcac gcgtttttgc cgcccatcag 58980 gctggcccag ttcccggcct gaaacacacg gtcgttgccg gccatgccgt agtatttgct 59040 gatgctcaac cccaacacga ccatggggcg cgccgccatg acgggccgca gcaggttgca 59 100 gctggcgaac atggacgtcc acgcgcccgg atgcgcgtcc acggcgtcca tcagcgcgcg 59160 ggccccggcc tccaggcccg ccccgccctg cgcggaccac gcggccgccg cctgcacgct 59220 ggggggacgg cgggaccccg cgatgatggc cgtgagggtg ttgatgaagt atgtcgagtg 59280 atcgcagtac cgcagaatct ggtttgccat gtagtacatc gccagctcgc tcacgttgtt 59340 gggggccagg ttaataaagt ttatcgcgcc gtagtccagg gaaaactttt taatgaacgc 59400 gatggtctcg atgtcctcgc gcgacaggag ccgggcggga agctggttgc gttggagggc 59460 cgtccagaac cactgcgggt tcggctggtt ggaccccggg ggcttgccgt tggggaagat 59520 ggccgcgtgg aactgcttca gcagaaagcc cagcggtccg aggaggatgt ccacgcgctt 59580 gtcgggcttc tggtaggcgc tctggaggct ggcgacccgc gccttggcgg cctcggacgc 59640 gttggcgctc gcgcccgcga acaacacgcg gctcttgacg cgcagctcct tgggaaaccc 59700 cagggtcacg cgggcaacgt cgccctcgaa gctgctctcg gcgggggccg tctggccggc 59760 cgttaggctg ggggcgcaga tagccgcccc ctccgagagc gcgaccgtca gcgttttggc 59820 cgacagaaac ccgttgttaa acatgtccat cacgcgccgc cgcagcaccg gttggaattg 59880 attgcgaaag ttgcgcccct cgaccgactg cccggcgaac accccgtggc actggctcag 59940 ggccaggtcc tgatacacgg cgaggttgga tcgccgcccg agaagctgaa gcagggggca 60000 tggcccgcac gcgtacgggt ccagcgtcag ggacatggcg tggttggcct cgcccagacc 60060 gtcgcgaaac ttgaagttcc tcccctccac caggttgcgc atcagctgct ccacctcgcg 60120 gtccacgacc tgcctgacgt tgttcaccac cgtatgcagg gcctcgcggt tggtgatgat 60180 ggtctccagc cgccccatgg ccgtggggac cgcctggtcc acgtactgca gggtctcgag 60240 ttcggccatg acgcgctcgg tcgccgcgcg gtacgtctcc tgcatgatgg tccgggcggt 60300 ctcggatccg tccgcgcgct tcagggccga gaaggcggcg tagtttccca gcacgtcgca 60360 gtcgctgtac atgctgttca tggtcccgaa gacgccgatg gctccgcggg cggcgctggc 60420 gaacttggga tggcgcgccc ggaggcgcat gagcgtcgtg tgtacgcagg cgtggcgcgt 60480 gtcgaaggtg cacaggttgc agggcacgtc ggtctggttg gagtccgcga cgtatcgaaa 60540 cacgtccatc tcctggcgcc cgacgatcac gccgccgtcg cagcgctcca ggtaaaacag 60600 catcttggcc agcagcgccg gggaaaaccc acacagcatg gccaggtgct cgccggcaaa 60660 ttcctgggtt ccgccgacga ggggcgcggt gggccgaccc tcgaacccgg gcaccacgtg 60720 tccctcgcgg tccacctgtg ggttggccgc cacgtgggtc ccgggcacga ggaagaagcg 60780 gtaaaaggag ggtttgctgt ggtcctttgg gtccgccgga ccggcgtcgt ccacctcggt 60840 gagatggagg gccgagttgg tgctaaatac catggccccc acgagtcccg cggcgcgcgc 60900 caggtacgcc ccgacggcgt tggcgcgggc cgcggccgtg tcctggccct cgcacagcgg 60960 ccacgcggag atgtcggtgg gcggctcgtc gaagacggcc atcgacacga tagactcgag 61020 ggccagggcg gcgtctccgg ccatgacgga ggccaggcgc tgttcgaacc cgcccgccgg 61080 gcccttgccg ccgccgtcgc gcccaccccg cggggtctta ccctggctgg cttcgaaggc 61140 cgtgaacgta atgtcggcgg ggagggcggc gccctcgtgg ttttcgtcaa acgccaggtg 61200 ggcggccgcg cgggccacgg cgtccacgtt tcggcatcgc agtgccacgg cggcgggtcc 61260 cacgaccgcc tcgaacagga ggcggttgag ggggcggtta aaaaacggaa gcgggtaggt 61320 aaaattctcc ccgatcgatc ggtggttggc gttgaacggc tcggcgatga cccggctaaa 61380 atccggcatg aacagctgca acggatacac gggtatgcgg tgcacctccg ccccgcctat 61440 ggttaccttg tccgagcctc ccaggtgcag aaaggtgttg ttgatgcaca cggcctcctt 61500 gaagccctcg gtaacgacca gatacaggag ggcgcggtcc gggtccaggc cgaggcgctc 61560 acacagcgcc tcccccgtcg tctcgtgttt gaggtcgccg ggccgggggg tgtagtccga 61620 aaagccaaaa tggcggcgtg cccgctcgca gagtcgcgtc aggtttgggg cctgggtgct 61680 ggggtccagg tgccggccgc cgtgaaagac gtacacggac gagctgtagt gcgatggcgt 61740 cagtttcagg gacaccgcgg tacccccgag ccccgtcgtg cgagaaccca cgaccacggc 61800 tacgttggcc tcaaagccgc tctccacggt caggcccacg accaggggcg ccacggcgac 61860 gtcggcatcg ccgctgcgcg ccgacagtaa cgccagaagc tcgatgcctt cggacggaca 61920 cgcgcgagcg tacacgtatc ccaggggccc gggggggacc ttgatggtgg ttgccgtctt 61980 gggctttgtc tccatgtcct cctggcaatc ggtccgcaaa cggaggtaat cccggcacga 62040 cgacggacgc ccgacgaggt atgtctcccg agcgtcaaaa tccggggggg ggggcggcga 62 100 cggtcaaggg gagggtggga gaccggggtt ggggaatgaa tccctaccct tcacagacaa 62160 cccccgggta accacggggt gccgatgaac cccggcggct ggcaacgcgg ggtccctgcg 62220 agaggcacag atgcttacgg tcaggtgctc cgggccgggt gcgtctgata tgcggttggt 62280 atatgtacac tttacctggg ggcgtgccgg accgccccag cccctcccac accccgcgcg 62340 tcatcagccg gtgggcgtgg ccgctattat aaaaaaagtg agaacgcgaa gcgttcgcac 62400 tttgtcctaa taatatatat attattagga caaagtgcga acgcttcgcg ttctcacttt 62460 ttttataata gcggccacgc ccaccggcta cgtcacgctc ctgtcggccg ccggcggtcc 62520 ataagcccgg ccggccgggc cgacgcgaat aaaccgggcc gccggccggg gcgccgcgca 62580 gcagctcgcc gcccggatcc gccagacaaa caaggccctt gcacatgccg gcccgggcga 62640 gcctgggggt ccggtaattt tgccatccca cccaagcggc ttttggggtt tttcctcttc 62700 ccccctcccc acatcccccc tctttagggg ttcgggtggg aacaaccgcg atgttttccg 62760 gtggcggcgg cccgctgtcc cccggaggaa agtcggcggc cagggcggcg tccgggtttt 62820 ttgcgcccgc cggccctcgc ggagccggcc ggggaccccc gccttgtttg aggcaaaact 62880 tttacaaccc ctacctcgcc ccagtcggga cgcaacagaa gccgaccggg ccaacccagc 62940 gccatacgta ctatagcgaa tgcgatgaat ttcgattcat cgccccgcgg gtgctggacg 63000 aggatgcccc cccggagaag cgcgccgggg tgcacgacgg tcacctcaag cgcgccccca 63060 aggtgtactg cgggggggac gagcgcgacg tcctccgcgt cgggtcgggc ggcttctggc 63120 cgcggcgctc gcgcctgtgg ggcggcgtgg accacgcccc ggcggggttc aaccccaccg 63180 tcaccgtctt tcacgtgtac gacatcctgg agaacgtgga gcacgcgtac ggcatgcgcg 63240 cggcccagtt ccacgcgcgg tttatggacg ccatcacacc gacggggacc gtcatcacgc 63300 tcctgggcct gactccggaa ggccaccggg tggccgttca cgtttacggc acgcggcagt 63360 acttttacat gaacaaggag gaggttgaca ggcacctaca atgccgcgcc ccacgagatc 63420 tctgcgagcg catggccgcg gccctgcgcg agtccccggg cgcgtcgttc cgcggcatct 63480 ccgcggacca cttcgaggcg gaggtggtgg agcgcaccga cgtgtactac tacgagacgc 63540 gccccgctct gttttaccgc gtctacgtcc gaagcgggcg cgtgctgtcg tacctgtgcg 63600 acaacttctg cccggccatc aagaagtacg agggtggggt cgacgccacc acccggttca 63660 tcctggacaa ccccgggttc gtcaccttcg gctggtaccg tctcaaaccg ggccggaaca 63720 acacgctagc ccagccgcgg gccccgatgg ccttcgggac atccagcgac gtcgagttta 63780 actgtacggc ggacaacctg gccatcgagg ggggcatgag cgacctaccg gcatacaagc 63840 tcatgtgctt cgatatcgaa tgcaaggcgg ggggggagga cgagctggcc tttccggtgg 63900 ccgggcaccc ggaggacctg gttattcaga tatcctgtct gctctacgac ctgtccacca 63960 ccgccctgga gcacgtcctc ctgttttcgc tcggttcctg cgacctcccc gaatcccacc 64020 tgaacgagct ggcggccagg ggcctgccca cgcccgtggt tctggaattc gacagcgaat 64080 tcgagatgct gttggccttc atgacccttg tgaaacagta cggccccgag ttcgtgaccg 64140 ggtacaacat catcaacttc gactggccct tcttgctggc caagctgacg gacatttaca 64200 aggtccccct ggacgggtac ggccgcatga acggccgggg cgtgtttcgc gtgtgggaca 64260 taggccagag ccacttccag aagcgcagca agataaaggt gaacggcatg gtgaacatcg 64320 acatgtacgg gatcataacc gacaagatca agctctcgag ctacaagctc aacgccgtgg 64380 ccgaagccgt cctgaaggac aagaagaagg acctgagcta tcgcgacatc cccgcctact 64440 acgccaccgg gcccgcgcaa cgcggggtga tcggcgagta ctgcatacag gattccctgc 64500 tggtgggcca gctgtttttt aagtttttgc cccatctgga gctctcggcc gtcgcgcgct 64560 tggcgggtat taacatcacc cgcaccatct acgacggcca gcagatccgc gtctttacgt 64620 gcctgctgcg cctggccgac cagaagggct ttattctgcc ggacacccag gggcgattta 64680 ggggcgccgg gggggaggcg cccaagcgtc cggccgcagc ccgggaggac gaggagcggc 64740 cagaggagga gggggaggac gaggacgaac gcgaggaggg cgggggcgag cgggagccgg 64800 agggcgcgcg ggagaccgcc ggccggcacg tggggtacca gggggccagg gtccttgacc 64860 ccacttccgg gtttcacgtg aaccccgtgg tggtgttcga ctttgccagc ctgtacccca 64920 gcatcatcca ggcccacaac ctgtgcttca gcacgctctc cctgagggcc gacgcagtgg 64980 cgcacctgga ggcgggcaag gactacctgg agatcgaggt gggggggcga cggctgttct 65040 tcgtcaaggc tcacgtgcga gagagcctcc tcagcatcct cctgcgggac tggctcgcca 65 100 tgcgaaagca gatccgctcg cggattcccc agagcagccc cgaggaggcc gtgctcctgg 65 160 acaagcagca ggccgccatc aaggtcgtgt gtaactcggt gtacgggttc acgggagtgc 65220 agcacggact cctgccgtgc ctgcacgttg ccgcgacggt gacgaccatc ggccgcgaga 65280 tgctgctcgc gacccgcgag tacgtccacg cgcgctgggc ggccttcgaa cagctcctgg 65340 ccgatttccc ggaggcggcc gacatgcgcg cccccgggcc ctattccatg cgcatcatct 65400 acggggacac ggactccata tttgtgctgt gccgcggcct cacggccgcc gggctgacgg 65460 ccatgggcga caagatggcg agccacatct cgcgcgcgct gtttctgccc cccatcaaac 65520 tcgagtgcga aaagacgttc accaagctgc tgctgatcgc caagaaaaag tacatcggcg 65580 tcatctacgg gggtaagatg ctcatcaagg gcgtggatct ggtgcgcaaa aacaactgcg 65640 cgtttatcaa ccgcacctcc agggccctgg tcgacctgct gttttacgac gataccgtat 65700 ccggagcggc cgccgcgtta gccgagcgcc ccgcagagga gtggctggcg cgacccctgc 65760 ccgagggact gcaggcgttc ggggccgtcc tcgtagacgc ccatcggcgc atcaccgacc 65820 cggagaggga catccaggac tttgtcctca ccgccgaact gagcagacac ccgcgcgcgt 65880 acaccaacaa gcgcctggcc cacctgacgg tgtattacaa gctcatggcc cgccgcgcgc 65940 aggtcccgtc catcaaggac cggatcccgt acgtgatcgt ggcccagacc cgcgaggtag 66000 aggagacggt cgcgcggctg gccgccctcc gcgagctaga cgccgccgcc ccaggggacg 66060 agcccgcccc ccccgcggcc ctgccctccc cggccaagcg cccccgggag acgccgtcgc 66120 atgccgaccc cccgggaggc gcgtccaagc cccgcaagct gctggtgtcc gagctggccg 66180 aggatcccgc atacgccatt gcccacggcg tcgccctgaa cacggactat tacttctccc 66240 acctgttggg ggcggcgtgc gtgacattca aggccctgtt tgggaataac gccaagatca 66300 ccgagagtct gttaaaaagg tttattcccg aagtgtggca ccccccggac gacgtggccg 66360 cgcggctccg ggccgcaggg ttcggggcgg tgggtgccgg cgctacggcg gaggaaactc 66420 gtcgaatgtt gcatagagcc tttgatactc tagcatgagc cccccgtcga agctgatgtc 66480 cctcatttta caataaatgt ctgcggccga cacggtcgga atctccgcgt ccgtgggttt 66540 ctctgcgttg cgccggacca cgagcacaaa cgtgctctgc cacacgtggg cgacgaaccg 66600 gtaccccggg cacgcggtga gcatccggtc tatgagccgg tagtgcaggt gggcggacgt 66660 gccgggaaag atgacgtaca gcatgtggcc cccgtaagtg gggtccgggt aaaacaacag 66720 ccgcgggtcg cacgccccgc ctccgcgcag gatcgtgtgg acgaaaaaaa gctcgggttg 66780 gccaagaatc ccggccaaga ggtcctggag gggggcgttg tggcggtcgg ccaacacgac 66840 caaggaggcc aggaaggcgc gatgctcgaa tatcgtgttg atctgctgca cgaaggccag 66900 gattagggcc tcgcggctgg tggcggcgaa ccgcccgtct cccgcgttgc acgcgggaca 66960 gcaacccccg atgcctaggt agtagcccat cccggagagg gtcaggcagt tgtcggccac 67020 ggtctggtcc agacagaagg gcagcgacac gggagtggtc ttcaccaggg gcaccgagaa 67080 cgagcgcacg atggcgatct cctcggaggg cgtctgggcg agggcggcga aaaggccccg 67 140 atagcgctgg cgctcgtgta aacacagctc ctgtttgcgg gcgtgaggcg gcaggctctt 67200 ccgggaggcc cgacgcacca cgcccagagt cccgccggcc gcagaggagc acgaccgccg 67260 gcgctccttg ccgtgatagg gcccgggccg ggagccgcgg cgatgggggt cggtatcata 67320 cataggtaca cagggtgtgc tccagggaca ggagcgagat cgagtggcgt ctaagcagcg 67380 cgcccgcctc acggacaaat gtggcgagcg cggtgggctt tggtacaaat acctgatacg 67440 tcttgaaggt gtagatgagg gcacgcaacg ctatgcagac acgcccctcg aactcgttcc 67500 cgcaggccag cttggccttg tggagcagca gctcgtcggg atgggtggcg gggggatggc 67560 cgaacagaac ccaggggtca acctccatct ccgtgatggc gcacatgggg tcacagaaca 67620 tgtgcttaaa gatggcctcg ggccccgcgg cccgcagcag gctcacaaac cggcccccgt 67680 ccccgggctg cgtctcgggg tccgcctcga gctggtcgac gacgggtacg atacagtcga 67740 agaggctcgt gttgttttcc gagtagcgga ccacggaggc ccggagtctg cgcagggcca 67800 gccagtaagc ccgcaccagt aacaggttac acagcaggca ttctccgccg gtgcgcccgc 67860 gcccccggcc gtgtttcagc acggtggcca tcagagggcc caggtcgagg tcgggctggg 67920 catcgggttc ggtaaactgc gcaaagcgcg gagccacgtc gcgcgtgcgt gccccgcgat 67980 gcgcttccca ggactggcgg accgtggcgc gacgggcctc cgcggcagcg cgcagctggg 68040 gccccgactc ccagacggcg ggggtgccgg cgaggagcag caggaccaga tccgcgtacg 68 100 cccacgtatc cggcgactcc tccggctcgc ggtccccggc gaccgtctcg aattccccgt 68 160 tgcgagcggc ggcgcgcgta cagcagctgt ccccgccccc gcgccgaccc tccgtgcagt 68220 ccaggagacg ggcgcaatcc ttccagttca tcagcgcggt ggtgagcgac ggctgcgtgc 68280 cggatcccgc cgccgacccc gccccctcct cgcccccgga ggccaaggtt ccgatgaggg 68340 cccgggtggc agactgcgcc aggaacgagt agttggagta ctgcaccttg gcggctcccg 68 400 gggagggcga gggcttgggt tgcttctggg catgccgccc gggcaccccg ccgtcggtac 68460 ggaagcagca gtggagaaaa aagtgccggt ggatgtcgtt tatggtgagg gcaaagcgtg 68520 cgaaggagcc gaccagggtc gccttcttgg tgcgcagaaa gtggcggtcc atgacgtaca 68580 caaactcgaa cgcggccacg aagatgctag cggcgcagtg gggcgccccc aggcatttgg 68640 cacagagaaa cgcgtaatcg gccacccact ggggcgagag gcggtaggtt tgcttgtaca 68700 gctcgatggt gcggcagacc agacagggcc ggtccagcgc gaaggtgtcg atggccgccg 68760 cggaaaaggg cccggtgtcc aaaagcccct ccccacaggg atccgggggc gggttgcggg 68820 gtcctccgcg cccgcccgaa ccccctccgt cgcccgcccc cccgcgggcc cttgaggggg 68880 cggtgaccac gtcggcggcg acgtcctcgt cgagcgtacc gacgggcggc acacctatca 68940 cgtgactggc cgccaggagc tcggcgcaga gagcctcgtt aagagccagg aggctgggat 69000 cgaaggccac atacgcgcgc tcgaacgccc ccgccttcca gctgctgccg ggggactctt 69060 cgcacaccgc gacgctcgcc aggaccccgg ggggcgaagt tgccatggct gggcgggagg 69 120 ggcgcacgcg ccagcgaact ttacgggaca caatccccga ctgcgcgctg cggtcccaga 69180 ccctggagag tctagacgcg cgctacgtct cgcgagacgg cgcgcatgac gcggccgtct 69240 ggttcgagga tatgaccccc gccgagctgg aggttgtctt cccgactacg gacgccaagc 69300 tgaactacct gtcgcggacg cagcggctgg cctccctcct gacgtacgcc gggcctataa 69360 aagcgcccga cgacgccgcc gccccgcaga ccccggacac cgcgtgtgtg cacggcgagc 69420 tgctcgcccg caagcgggaa agattcgcgg cggtcattaa ccggttcctg gacctgcacc 69480 agattctgcg gggctgacgc gcgcgctgtt gggcgggacg gttcgcgaac cctttggtgg 69540 gtttacgcgg gcacgcacgc tcccatcgcg ggcgccatgg cgggactggg caagccctac 69600 cccggccacc caggtgacgc cttcgagggt ctcgttcagc gaattcggct tatcgtccca 69660 tctacgttgc ggggcgggga cggggaggcg ggcccctact ctccctccag cctcccctcc 69720 aggtgcgcct ttcagtttca tggccatgac gggtccgacg agtcgtttcc catcgagtat 69780 gtactgcggc ttatgaacga ctgggccgag gtcccgtgca acccttacct gcgcatacag 69840 aacaccggcg tgtcggtgct gtttcagggg ttttttcatc gcccacacaa cgcccccggg 69900 ggcgcgatta cgccagagcg gaccaatgtg atcctgggct ccaccgagac gacggggctg 69960 tccctcggcg acctggacac catcaagggg cggctcggcc tggatgcccg gccgatgatg 70020 gccagcatgt ggatcagctg ctttgtgcgc atgccccgcg tgcagctcgc gtttcggttc 70080 atgggccccg aagatgccgg acggacgaga cggatcctgt gccgcgccgc cgagcaggct 70140 attacccgtc gccgccgaac ccggcggtcc cgggaggcgt acggggccga ggccgggctg 70200 ggggtggctg gaacgggttt ccgggccagg ggggacggtt ttggcccgct ccccttgtta 70260 acccaagggc cctcccgccc gtggcaccag gccctgcggg gtcttaagca cctacggatt 70320 ggcccccccg cgctcgtttt ggcggcggga ctcgtcctgg gggccgctat ttggtgggtg 70380 gttggtgctg gcgcgcgcct ataaaaaagg acgcaccgcc gccctaatcg ccagtgcgtt 70440 ccggacgcct tcgccccaca cagccctccc gtccgacacc cccatatcgc ttcccgacct 70500 ccggtcccga tggccgtccc gcaatttcac cgccccagca ccgttaccac cgatagcgtc 70560 cgggcgcttg gcatgcgcgg gctcgtcttg gccaccaata actctcagtt tatcatggat 70620 aacaaccacc cgcaccccca gggcacccaa ggggccgtgc gggagtttct ccgcggtcag 70680 gcggcggcgc tgacggacct tggtctggcc cacgcaaaca acacgtttac cccgcagcct 70740 atgttcgcgg gcgacgcccc ggccgcctgg ttgcggcccg cgtttggcct gcggcgcacc 70800 tattcaccgt ttgtcgttcg agaaccttcg acgcccggga ccccgtgagg cccggggagt 70860 tccttctggg gtgttttaat caataaaaga ccacaccaac gcacgagcct tgcgtttaat 70920 gtcgtgttta ttcaagggag tgggataggg ttcgacggtt cgaaacttaa cacacaaaat 70980 aatcgagcgc gtctagccca gtaacatgcg cacgtgatgt aggctggtca gcacggcgtc 71040 gctgtgatga agcagcgccc ggcgggtccg ctgtaactgc tgttgtaggc ggtaacaggc 71 100 gcggatcagc accgccaggg cgctacgacc ggtgcgttgc acgtagcgtc gcgacagaac 71 160 tgcgtttgcc gatacgggcg gggggccgaa ttgtaagcgc gtcacctctt gggagtcatc 71220 ggcggataac gcactgaatg gttcgttggt tatgggggag tgtggttccc gagggagtgg 71280 gtcgagcgcc tcggcctcgg aatccgagag gaacaacgag gtggtgtcgg agtcttcgtc 71340 gtcagagaca tacagggtct gaagcagcga cacgggcggg ggggtagcgt caatgtgtag 71400 cgcgagggag gatgcccacg aagacacccc agacaaggag ctgcccgtgc gtggatttgt 71460 ggacgacgcg gaagccggga cggatgggcg gttttgcggt gcccggaacc gaaccgccgg 71520 atactccccg ggtgctacat gcccgttttg gggctggggt tggggctggg gctggggttg 71580 gggttggggc tggggttggg gctggggttg gggctggggt tggggttggg gttggggctg 71640 gggttggggt tggggctggg gctggggctg gggctggggc tggggctggg gctggggctg 71700 gggctggggc tggggctggg gctggggctg gggctggggt tggggctggg gttggggctg 71760 gggcgcggac aggcggttga cggtcaaatg cccccggggg cgcgcagatg tggtgggcgt 71820 ggccaccggc tgccgtgtag tggggcggcg ggaaaccggg cctccgggcg taacaccgcc 71880 ctccagcgtc aagtatgtgg ggggcgggcc tgacgtcggg ggcggggtga cgggttggac 71940 cgcgggaggc gggggagagg gacctgcggg agaggatgag gtcggctcgg ccgggttgcg 72000 gcctaaaaca ggggccgtgg ggtcggcggg gtcccagggt gaagggaggg attcccgcga 72060 ttcggacagc gacgcgacag cggggcgcgt aaggcgccgc tgcggcccgc ctacgggaac 72 120 cctggggggg gttggcgcgg gacccgaggt tagcgggggg cggcggtttt cgcccccggg 72180 caaaaccgtg ccggttgcga ccgggggcgg aacgggatcg atagggagag cgggagaagc 72240 ctggccggcg aactggggac cgagcgggag gggcacacca gacaccaaag cgtggagcgc 72300 tggctctggg ggtttgggag gggccggggg gcgcgcgaaa tcggtaaccg gggcgaccgt 72360 gtcggggagg gcaggcggcc gccaaccctg ggtggtcgcg gaagcctggg tggcgcgcgc 72420 cagggagcgt gcccggcggt gtcggcgcgc gcgcgacccg gacgaagaag cggcagaagc 72480 gcgggaggag gcgggggggc ggggggcggt ggcatcgggg ggcgccgggg aactttgggg 72540 ggacggcaag cgccggaagt cgtcgcgggg gcccacgggc gccggccgcg tgctttcggc 72600 cgggacgccc ggtcgtgctt cgcgagccgt gactgccggc ccagggggcc gcggtgcaca 72660 ctgggacgtg gggacggact gatcggcggt gggcgaaagg gggtccgggg caaggagggg 72720 cgcggggccg ccggagtcgt cagacgcgag ctcctccagg ccgtgaatcc atgcccacat 72780 gcgagggggg acgggctcgc cgggggtggc gtcggtgaat agcgtggggg ccaggcttcc 72840 gggccccaac gagccctccg tcccaacaag gtccgccggg ccgggggtcg ggttcgggac 72900 cgaggggctc tggtcgtcgg gggcgcgctg gtacaccgga tgccccggga atagctcccc 72960 cgacaggagg gaggcgtcga acggccgccc gaggatagct cgcgcgagga aggggtcctc 73020 gtcggtggcg ctggcggcga ggacgtcctc gccgcccgcc acaaacggga gctcctcggt 73080 ggcctcgctg ccaacaaacc gcacgtcggg ggggccgggg gggtccgggt tttcccacaa 73140 caccgcgacc ggggtcatgg agatgtccac gagcaccaga cacggcgggc cccgggcgag 73200 gggccgctcg gcgatgagcg cggacaggcg cgggagctgt gccgccagac acgcgttttc 73260 aatcgggttc aggtcggcgt gcaggaggcg gacggcccac gtctcgatgt cggacgacac 73320 ggcatcgcgc aaggcggcgt ccggcccgcg agcgcgtgag tcaaacagcg tgagacacag 73380 ctccagctcc gactcgcggg aaaaggccgt ggtgttgcgg agcgccacga cgacgggcgc 73440 gcccaggagc actgccgcca gcaccaggtc catggccgta acgcgcgccg cgggggtgcg 73500 gtgggtggcg gcggccggca cggcgacgtg ctggcccgtg ggccggtaga gggcgttggg 73560 gggagcgggg ggtgacgcct cgcgcccccc cgaggggctc agcgtctgcc cagattccag 73620 acgcgcggtc agaagggcgt cgaaactgtc atactctgtg tagtcgtccg gaaacatgca 73680 ggtccaaaga gcggccagag cggtgcttgg gagacacatg cgcccgagga cgctcaccgc 73740 cgccagcgcc tgggcgggac tcagctttcc cagcgcggcg ccgcgctcgg ttcccagctc 73800 ggggaccgag cgccagggcg ccagggggtc ggtttcggac aacttgccgc ggcgccagtc 73860 tgccagccgc gtgccgaaca tgaggccccg ggtcggaggg cctccggtcg aaaacactgg 73920 cagcacgcgg atgcgggcgt ctggatgcgg ggtcaggcgc tgcacgaata gcatggaatc 73980 tgctgcgttc tgaaacgcac gggggagggt gagatgcatg tactcgtgtt ggcggaccag 74040 atccaggcgc caaaaggtgt aaatgtgttc cggggagctg gccaccagcg ccaccagcac 74 100 gtcgttctcg ttaaaggaaa cgcggtgcct agtggagctg tggggcccga gcggcggtcc 74 160 cggggccgcc gcgtcacccc cccattccag ctgggcccag cgacacccaa actcgcgcgt 74220 gagagtggtc gcgacgaggg cgacgtagag ctcggccgcc gcatccatcg aggcccccca 74280 tctcgcctgg cggtggcgca caaagcgtcc gaagagctga aagttggcgg cctgggcgtc 74340 gctgagggcc agctgaagcc ggttgatgac ggtgatgacg tacatggccg tgacggtcga 74400 ggccgactcc agggtgtccg tcggaagcgg ggggcgaatg catgccgcct cgggacacat 74460 cagcagcgcg ccgagcttgt cggtcacggc cgggaagcag agcgcgtact gcagtggcgt 74520 tccatccggg accaaaaagc tgggggcgaa cggccgatcc agcgtactgg tggcctcgcg 74580 cagcaccagg ggccccgggc ctccgctcac tcgcaggtac gcctcgcccc ggcggcgcag 74640 catctgcggg tcggcctctt ggccgggtgg ggcggacgcc cgggcgcggg cgtctagggc 74700 gcgaagatcc acgagcaggg gcgcgggcgc ggcggccgcg cccgcgcccg tctggcctgt 74760 ggccttggcg tacgcgctat ataagcccat gcggcgttgg atgagctccc gcgcgccccg 74820 gaactcctcc accgcccatg gggccaggtc cccggccacc gcgtcgaatt ccgccaacag 74880 gccccccagg gtgtcaaagt tcatctccca ggccaccctt ggcaccacct cgtcccgcag 74940 ccgggcgctc aggtcggcgt gttgggccac gcgccccccg agctcctcca cggccccggc 75000 ccgctcggcg ctcttggcgc ccaggacgcc ctggtacttg gcgggaaggc gctcgtagtc 75060 ccgctgggct cgcagccccg acacagtgtt ggtggtgtcc tgcagggcgc gaagctgctc 75 120 gcatgccgcg cgaaatccct cgggcgattt ccaggccccc ccgcgaacgc ggccgaagcg 75180 accccatacc tcgtcccact ccgcctcggc ctcctcgaga gacctccgca gggcctcgac 75240 gcggcgacgg gtgtcgaaga gcgcctgcag gcgcgcgccc tgtcgcgtca ggaggcccgg 75300 gccgtcgccg ctggccgcgt ttagcgggtg cgtctcaaag gtacgctggg catgttccaa 75360 ccaggcgacc gcctgcacgt cgagctcgcg cgccttctcc gtctggtcca acagaatttc 75420 gacctgatcc gcgatctcct ccgccgagcg cgcctggtcc agcgtcttgg ccacggtcgc 75480 cgggacggcg accaccttca gcagggtctt cagattggcc agaccctcgg cctcgagctg 75540 ggcccggcgc tcgcgcgcgg ccagcacctc ccgcagcccc gccgtgaccc gctcggtggc 75600 ttcggcgcgc tgctgtttgg cgcgcaccac ggcgtccttg gtatcggcca ggtcctgtcg 75660 ggtcacgaat gcgacgtagt cggcgtacgc cgtgtccttc acggggctct ggtccacgcg 75720 ctccagcgcc gccacgcacg ccaccagcgc gtcctcgctc gggcagggca gggtgacccc 75780 tgcccggaca agctcggcgg ccgccgccgg gtcgttgcgc accgcggata tctcctccgc 75840 ggcggcggcc aggtccagcg ccacgcttcc gatcgcgcgc cgcgcgtcgg cccggagggc 75900 gtccaggcga tcgcggatat ccacgtactc ggcgtagccc ttttgaaaaa acggcacgta 75960 ctggcgcagg gccggcacgc cccccaagtc ttccgacagg tgtaggacgg cctcgtggta 76020 gtcgataaac ccgtcgttcg cctgggcccg ctccagcagc ccccccgcca gccgcagaag 76080 ccgcgccagg ggctcggtgt ccacccgaaa catgtcggcg tacgtgtcgg ccgcggcccc 76 140 gaaggccgcg ctccagtcga tgcggtgaat ggctgcgagc ggggggagca tggggtggcg 76200 ctggttctcg ggggtgtatg ggttaaacgc aagggccgtc tccagggcaa gggtcaccgc 76260 cttggcgttg gttcccagcg cctgttcggc ccgctttcgg aagtcccggg ggttgtagcc 76320 gtgcgtgccc gccagcgcct gcaggcgacg gagctcgacc acgtcaaact cggcaccgct 76380 ttccacgcgg tccagcacgg cctccacgtc ggcggcccag cgctcgtggc tactgcgggc 76440 gcgctgggcc gccatcttct ctctcaggtc ggcgatggcg gcctcaagtt cgtcggcgcg 76500 gcgtcgcgtg gcgccgatga cctttcccag ctcctgcagg gcgcgcccgc tgggggagtg 76560 gtccccggcc gtcccttcgg cgtgcaacag gcccccgaac ctgccctcgt ggcccgcgag 76620 gctttcccgc gcgccggtgg tcgcgcgcgt cgcggcctgg atcagggagg catgctctcc 76680 ctccggttgg ttggcggccc ggcgcacctg gacgacaagg tcggctgccg ccgaccctaa 76740 ggtcgtgagc tgggcgatgg ccccccgcgc gtccagggcc aaccgagtcg ccttgacgta 76800 tcccgcggcg ctgtcggcca tggccgctag gaaggccagg ggggaggccg ggtcgctggc 76860 ggccgcgccc agggccgtca ccgcgtcgac caggacgcgg tgcgcccgca cggccgcatc 76920 caccgtcgac gcggggtctg ccgtcgcgac ggcggcgctg ccggcgttga tggcgttcga 76980 gacggcgtgg gctatgatcg gggcgtgatc ggcgaagaac tgcaagagaa acggagtctc 77040 tggggcgtcg gcgaacaggt tcttcagcac caccacgaag ctgggatgca agccagacag 77 100 agccgtcgcc gtgtccggag tcgggtgctc cagggcatct cggtactgcc ccagcagccc 77160 ccacatgtcc gcccgcagcg ccgccgtaac ctcagggggc gccccccgaa cggcctcggg 77220 gaggtccgac cagcccgccg gcagggaggc ccgcagggtc gccaggacgg ccggacaggc 77280 ctttagcccc acaaagtcag ggagggggcg caggaccccc tggagtttgt gcaagaactt 77340 ctcccgggcg tcgcgggcca ccttcgcccg ctcccgcgct ccctcgagca ttgcctccag 77400 ggagcgcgcg cgctcccgca aacgggcacg cgcatcgggg gcgagctctg ccgtcagctt 77460 ggcggcatcc atggcccgcg cctgccgcag cgcttcctcg gccatgcgcg tggcctctgg 77520 cgacagcccg ccgtcgtcgg ggtagggcga cgcgccgggc gcaggaacaa aggccgcgtc 77580 gctgtccagc tgctggccca gggccgcatc tagggcgtcg aagcgccgca gctcggccag 77640 acccgagctg cggcgcgcct gctggtcgtt aatgtcgcgg atgctgcgcg ccagctcgtc 77700 cagcggcttg cgttctatca gcccttggtt ggcggcgtcc gtcaggacgg agagccaggc 77760 cgccaggtcc tcgggggcgt ccagcgtctg gccccgctgg atcagatccc gcaacaggat 77820 ggccgtgggg ctggtcgcga tcgggggcgg ggcgggaatg gcggcgcgct gcgcgatgtc 77880 ccgcgtgtgc tggtcgaaga caggcaggga ctcgagcagc tggaccacgg gcacgacggc 77940 ggccgaagcc acgtgaaacc ggcggtcgtt gttgtcgctg gcctgtagag ccttggcgct 78000 gtatacggcc ccccggtaaa agtactcctt aaccgcgccc tcgatcgccc gacgggcctg 78060 ggtccgcacc tcctccagcc gaacctgaac ggcctcgggg cccagggggg gtgggcgcgg 78 120 agccccctgc ggggccgccc cggccggggc gggcattacg ccgaggggcc cggcgtgctg 78180 tgagaccgcg tcgaccccgc gagcgagggc gtcgagggcc tcgcgcatct ggcgatcctc 78240 cgcctccacc ctaatctctt cgccacgggc aaatttggcc agagcctgga ctctatacag 78300 aagcggttct gggtgcgtcg gggtggcggg ggcaaaaagg gtgtccgggt gggcctgcga 78360 gcgctccaga agccactcgc cgaggcgtgt atacagattg gccggcgggg ccgcgcgaag 78420 ctgcagctcc aggtccgcga gttccccgta aaaggcgtcc gtctcccgaa tgacatccct 78480 agccacaagg atcagcttcg ccagcgccag gcgaccgatc agagagtttt cgtccagcac 78540 gtgctggacg aggggcagat gggcggccac gtcggccagg ctcaggcgcg tggaggccag 78600 aaagtccccc acggccgttt tccggggcag catgctcagg gtaaactcca gcagggcggc 78660 ggccgggccg gccaccccgg cctgggtgtg cgtccgggcc ccgttctcga tgagaaaggc 78720 gaggacgcgt tcaaagaaaa aaataacaca gagctccagc agccccggag aagccggata 78780 cggcgaccgt aaggcgctga tggtgagccg cgaacacgcg gcgacctcgc gggccagggt 78840 ggcggagcac gcggtgaact taaccgccgt ggcggccacg tttgggtggg cctcgaacag 78900 ctgggcgagg tctgcgcccg ggggctcggg tgagcggcga gtcttcagcg cctcgagggc 78960 ctgtgaggac gccggaacca tgggcccgtc gtcctcgccc gcctcggcga ccggcggccc 79020 ggccgggtcg gggggtgccg aggcgaggac aggctccgga acggaggcgg ggaccgcggc 79080 cccgacgggg gttttgcctt tgggggtgga tttcttcttg gttttggcag ggggggccga 79 140 gcgtttcgtt ttctcccccg aagtcaggtc ttcgacgctg gaaggcggag tccaggtggg 79200 tcggcggcgc ttgggaaggc cggccgagta gcgtgcccgg tgccgaccaa ccgggacgac 79260 gcccatctcc aggacccgca tgtcgtcgtc atcttcttcg gccgcctctg cggcgggggt 79320 cttgggggcg gagggaggcg gtggtgggat cgcggagggt gggtcggcgg aggggggatc 79380 cgtgggtggg gtacccttta gggccaccgc ccatacatcg tcgggcgccc gattcgggcg 79440 cttggcctct ggttttgccg acggaccggc cgtcccccgg gatgtctcgg aggccctgtc 79500 gtcgcgacgg gcccgggtcg gtggcggcga ctgggcggct gtgggcgggt gtggccccgg 79560 cccccctccc ccctcccggg ggcccacgcc gacgcagggc tcccccaggc ccgcgatctc 79620 gccccgcagg gggtgcgtga tggccacgcg ccgttcgctg aacgcttcgt cctgcatgta 79680 agtctcgctg gccccgtaaa gatgcagagc cgcggccgtc aagtccgcag gagccgcggg 79740 ttccgggccc gacggcacga aaaacaccat ggctcccgcc caccgtacgt ccgggcgatc 79800 gcgggtgtaa tacgtcaggt atggatacat gtcccccgcc cgcactttgg cgatgaacgc 79860 gggggtgccc tccggaaggc catgcgggtc aaaaaggtat gcggtgtcgc cgtccctgaa 79920 cagccccatc cctagggggc caatggttag gagcgtgtac gacagggggc gcagggccca 79980 cgggccggcg aagaacgtgt gtgcggggca ttgtgtctcc agcaggcctg ccgcgggctc 80040 cccgaagaag cccacctcgc cgtatacgcg cgagaagaca cagcgcagtc cgccgcgcgc 80 100 ccctgggtac tcgaggaagt tggggagctc gacgatcgaa cacatgcgcg gcggcccagg 80 160 gcccgcagtc gcgcgcgtcc actcgccccc ctcgaccaaa catccctcga tggcctccgc 80 220 ggacagaacg tcgcgagggc ccacatcaaa tatgaggctg agaaaggaca gcgacgagcg 80280 catgcacgat accgaccccc ccggctccag gtcgggcgcg aactggttcc gagcaccggt 80340 gaccacgatg tcgcgatccc ccccgcgttc catcgtggag tgcggtgggg tgcccgcgat 80 400 catatgtgcc ctgcgggcca gagacccggc ctgtttatgg accggacccc cggggttagt 80460 gttgtttccg ccacccacgc ccccgtacca tggccccggt tcccctgatt aggctacgag 80520 tcgcggtgat cgcttcccaa aaaccgagct gcgtttgtct gtcttggtct tccccccccc 80580 cagcccgcac accataacac cgagaacaac acacgggggt gggcggaaca taataaagct 80640 ttattggtaa ctagttaacg gcaagtccgt gggtggcgcg acggtgtcct ccgggatcat 80700 ctcgtcgtcc tcgacggggg tgttggaatg aggcgcctcc tcgcggtcca cctggcgtgg 80760 gccgtgccca taggcctccg gcttctgtgc gtccatgggc gtaggcgcgg ggagactgtt 80820 tccggcgtcg cggacctcca ggtccctggg agcctccggt ccggctaacg gacgaaacgc 80880 ggaagcgcga aacacgccgt cggtgacccg caggagctcg ttcatcagta accaatccat 80940 actcagcgta acggccagcc cctggcgaga cagatccacg gagtccggaa ccgcggtcgt 81000 ctggcccagg gggccgaggc tgtagtcccc ccaggcccct aggtcgcgac ggctcgtaag 81060 cacgacgcgg tcggccgcgg ggctttgcgg gggggcgtcc tcgggcgcat gcgccattac 81120 ctctcggatg gccgcggcgc gctggtcggc cgagctgacc aagggcgcca cgaccacggc 81180 gcgctccgtc tgcaggccct tccacgtgtc gtggagttcc tggacaaact cggccacggg 81240 ctcgggtccc gcggccgcgc gcgcggcttg atagcaggcc gacagacgcc gccagcgcgc 81300 tagaaactga cccatgaaac aaaacccggg gacctggtct cccgacagca gcttcgacgc 81360 ccgggcgtga atgccggaca cgacggacag aaacccgtga atttcgcgcc ggaccacggc 81420 cagcacgttg tcctcgtgcg acacctgggc cgccagctcg tcgcacaccc ccaggtgcgc 81480 cgtggtttcg gtgatgacgg aacgcaggct cgcgagggac gcgaccagcg cgcgcttggc 81540 gtcgtgatac atgctgcagt actgactcac cgcgtccccc atggcctcgg ggggccaggg 81600 ccccaggcgg tcgggcgtgt ccccgaccac cgcatacagg cggcgcccgt cgctctcgaa 81660 ccgacactcg aaaaaggcgg agagcgtgcg catgtgcagc cgcagcagca cgatggcgtc 81720 ctccagttgg cgaatcaggg ggtcggcgcg ctcggcgagg tcctgcagca ccccccgggc 81780 agccagggcg tacatgctaa tcaacaggag gctggtgccc acctcggggg gcgggggggg 81840 ctgcagttgg accaggggcc gcagctgctc gacggcaccc ctggagatca cgtacagctc 81900 ccggagcagc tgctctatgt tgtcggccat ctgcatagtg gggccgaggc cgccccgggc 81960 ggccggttcg aggagagtga tcagcgcgcc cagtttggtg cgatggccct cgaccgtggg 82020 gagatagccc agcccaaagt cccgggccca ggccaacaca cgcagggcga actcgaccgg 82080 gcggggaagg taggccgcgc tacacgtggc cctcagcgcg tccccaacca ccagggccag 82140 aacgtagggg acgaagcccg ggtcggcgag gacgttgggg tgaatgccct cgagggcggg 82200 gaagcggatc tgggtcgccg cggccaggtg gacagagggg gcatggctgg gctgcccgac 82260 ggggagaagc gcggacagcg gcgtggccgg ggtggtgggg gtgatgtccc agtgggtctg 82320 accatacacg tcgatccaga tgagcgccgt ctcgcggaga aggctgggtt gaccggaact 82380 aaagcggcgc tcggccgtct caaactcccc cacgagcgcc cgccgcaggc tcgccagatg 82440 ttccgtcggc acggccggcc ccatgatacg cgccagcgtc tggctcagaa cgccccccga 82500 caggccgacc gcctcacaga gccgcccgtg cgtgtgctcg ctggcgccct ggacccgcct 82560 gaaagttttt acgtagttgg catagtaccc gtattcccgc gccagaccaa acacgttcga 82620 ccccgcgagg gcaatgcacc caaagagctg ctggacttcg ccgagtccgt ggccggcggg 82680 cgtccgcgcg gggacgcccg ccgccagaaa cccctccagg gccgaaaggt agtgcgtgca 82740 gtgcgagggc gtgaacccag cgtcgatcag ggtgttgatc accacggagg gcgaattggt 82800 attctggatc aacgtccacg tctgctgcag cagagccagc agccgctgct gggcgccggc 82860 ggagggctgc tccccgagct gcagcaggct ggagacggca ggctggaaga ctgccagtgc 82920 cgacgaactc aggaacggca cgtcgggatc aaacacggcc acgtccgtcc gcacgcgcgc 82980 cattagcgtc cccgggggcg cacaggccga gcgcgggctg acgcggctga gggccgtcga 83040 cacgcgcacc tcctcgcggc tgcgaaccat cttgttggcc tccagtggcg gaatcattat 83100 ggccgggtcg atctcccgca cggtgtgctg aaactgcgcc aacaggggcg gcgggaccac 83 160 agccccccgc tcgggggtcg tcaggtactc gtccaccagg gccaacgtaa agagggcccg 83220 tgtgagggga gtgagggtcg cgtcgtctat gcgctggagg tgcgccgaga acagcgtcac 83280 ccgattactc accagggcca agaaccggag gccctcttgc acgaacgggg cggggaagag 83340 caggctgtac gccggggtgg taaggttcgc gctgggctgc cccaacggga ccggcgccag 83400 cttgagcgac gtctccccaa gggcctcgat ggaggtccgc gggctcatgg ccaagcagct 83460 cttggtgacg gtttgccagc ggtctatcca ctccacggcg cactggcgga cgcggaccgg 83520 ccccagggcc gccgcggtgc gcaggccggc ggactccagc gcatgggacg tgtcggagcc 83580 ggtgaccgcg aggatggtgt ccttgatgac ctccatctcc cggaaggcct ggtcgggggc 83640 ctcggggaga gccaccacca agcggtgtac gagcaacccg gggaggttct cggccaagag 83700 cgccgtctcc ggaagcccgt gggcccggtg gagcgcgcac aggtgttcca gcagcggccg 83760 ccagcatgcc cgcgcgtctg ccggggcgat ggccgttccc gacaacagaa acgccgccat 83820 ggcggcgcgc agcttggccg tggccagaaa cgccgggtcg tccgccccgt ttgccgtctc 83880 ggccgtgggg gttggcggtt ggcgaaggcc ggctaggctc gccaataggc gctgcatagg 83940 tccgtccgag ggcggaccgg cgggtgaggt cgtgacgacg ggggcctcgg acgggagacc 84000 gcggtctgcc atgacgcccg gctcgcgtgg gtgggggaca gcgtagacca acgacgagac 84060 cgggcgggaa tgactgtcgt gcgctgtagg gagcggcgaa ttatcgatcc cccgcggccc 84 120 tccaggaacc ccgcaggcgt tgcgagtacc ccgcgtcttc gcggggtgtt atacggccac 84180 ttaagtcccg gcatcccgtt cgcggaccca ggcccggggg attgtccgga tgtgcgggca 84 240 gcccggacgg cgtgggttgc ggactttcgg cggggcggcc caaatggccc tttaaacgtg 84300 tgtatacgga cgcgccgggc cagtcggcca acacaaccca ccggaggcgg tagccgcgtt 84360 tggctgtggg gtgggtggtt ccgccttgcg tgagtgtcct ttcgaccccc cccctccccc 84420 gggtcttgct aggtcgcgat ctgtggtcgc aatgaagacc aatccgctac ccgcaacccc 84480 ttccgtgtgg ggcgggagta ccgtggaact cccccccacc acacgcgata ccgcggggca 84540 gggcctgctt cggcgcgtcc tgcgcccccc gatctctcgc cgcgacggcc cagtgctccc 84600 cagggggtcg ggaccccgga gggcggccag cacgctgtgg ttgcttggcc tggacggcac 84660 agacgcgccc cctggggcgc tgacccccaa cgacgatacc gaacaggccc tggacaagat 84 720 cctgcggggc accatgcgcg ggggggcggc cctgatcggc tccccgcgcc atcatctaac 84780 ccgccaagtg atcctgacgg atctgtgcca acccaacgcg gatcgtgccg ggacgctgct 84840 tctggcgctg cggcaccccg ccgacctgcc tcacctggcc caccagcgcg ccccgccagg 84900 ccggcagacc gagcggctgg gcgaggcctg gggccagctg atggaggcga ccgccctggg 84960 gtcggggcga gccgagagcg ggtgcacgcg cgcgggcctc gtgtcgttta acttcctggt 85020 ggcggcgtgt gccgcctcgt acgacgcgcg cgacgccgcc gatgcggtac gggcccacgt 85080 cacggccaac taccgcggga cgcgggtggg ggcgcgcctg gatcgttttt ccgagtgtct 85 140 gcgcgccatg gttcacacgc acgtcttccc ccacgaggtc atgcggtttt tcggggggct 85200 ggtgtcgtgg gtcacccagg acgagctagc gagcgtcacc gccgtgtgcg ccgggcccca 85260 ggaggcggcg cacaccggcc acccgggccg gccccgctcg gccgtgatcc tcccggcgtg 85320 tgcgttcgtg gacctggacg ccgagctggg gctggggggc ccgggcgcgg cgtttctgta 85380 cctggtattc acttaccgcc agcgccggga ccaggagctg tgttgtgtgt acgtgatcaa 85440 gagccagctc cccccgcgcg ggttggagcc ggccctggag cggctgtttg ggcgcctccg 85500 gatcaccaac acgattcacg gcaccgagga catgacgccc ccggccccaa accgaaaccc 85560 cgacttcccc ctcgcgggcc tggccgccaa tccccaaacc ccgcgttgct ctgctggcca 85620 ggtcacgaac ccccagttcg ccgacaggct gtaccgctgg cagccggacc tgcgggggcg 85680 ccccaccgca cgcacctgta cgtacgccgc ctttgcagag ctcggcatga tgcccgagga 85740 tagtccccgc tgcctgcacc gcaccgagcg ctttggggcg gtcagcgtcc ccgttgtcat 85800 cctggaaggc gtggtgtggc gccccggcga gtggcgggcc tgcgcgtgag cgtagcaaac 85860 gccccgccca cacaacgctc cgcccccaac cccttccccg ctgtcactcg ttgttcgttg 85920 acccggacgt ccgccaaata aagccactga aacccgaaac gcgagtgttg taacgtcctt 85980 tgggcgggag gaagccacaa aatgcaaatg ggatacatgg aaggaacaca cccccgtgac 86040 tcaggacatc ggcgtgtcct tttgggtttc actgaaactg gcccgcgccc cacccctgcg 86 100 cgatgtggat aaaaagccag cgcgggtggt ttagggtacc acaggtgggt gctttggaaa 86 160 cttgtcggtc gccgtgctcc tgtgagcttg cgtccctccc cggtttcctt tgcgctcccg 86220 ccttccggac ctgctctcgc ctatcttctt tggctctcgg tgcgattcgt caggcagtgg 86280 ccttgtcgaa tctcgacccc accactcgcc ggacccgccg acgtcccctc tcgagcccgc 86340 cgaaacccgc cgcgtctgtt gaaatggcca gccgccccgc cgcatcctct cccgtcgaag 86400 cgcgggcccc ggttggggga caggaggccg gcggccccag cgcagccacc cagggggagg 86460 ccgccggggc ccctctcgcc cgcggccacc acgtgtactg ccagcgagtc aatggcgtga 86520 tggtgctttc cgacaagacg cccgggtccg cgtcctaccg catcagcgat agcaactttg 86580 tccaatgtgg ttccaactgc accatgatca tagacggaga cgtggtgcgc gggcgccccc 86640 aggacccggg ggccgcggca tcccccgctc ccttcgttgc ggtgacaaac atcggagccg 86700 gcagcgacgg cgggaccgcc gtcgtggcat tcgggggaac cccacgtcgc tcggcgggga 86760 cgtctaccgg tacccagacg accgacgtcc ccaccgaggc ccttgggggc ccccctcctc 86820 ctccccgctt caccctgggt ggcggctgtt gttcctgtcg cgacacacgg cgccgctctg 86880 cggtattcgg gggggagggg gatcccgtcg gccccgcgga gttcgtctcg gacgaccggt 86940 cgtccgattc cgactcggat gactcggagg acaccgactc ggagacgctg tcacacgcct 87000 cctcggacgt gtccggcggg gccacgtacg acgacgccct tgactccgat tcgtcatcgg 87060 atgactccct gcagatagat ggccccgtgt gtcgcccgtg gagcaatgac accgcgcccc 87 120 tggatgtttg ccccgggacc cccggcccgg gcgccgacgc cggtggtccc tcagcggtag 87180 acccacacgc accgacgcca ggggccggcg ctggtcttgc ggccgatccc gccgtggccc 87 240 gggacgacgc ggaggggctt tcggaccccc ggccacgtct gggaacgggc acggcctacc 87300 ccgtccccct ggaactcacg cccgagaacg cggaggccgt ggcgcgcttt ctgggagatg 87360 ccgtgaaccg cgaacccgcg ctcatgctgg agtacttttg ccggtgcgcc cgcgaggaaa 87420 ccaagcgtgt cccccccagg acattctgca gcccccctcg cctcacggag gacgactttg 87480 ggcttctcaa ctacgcgctc gtggagatgc agcgcctgtg tctggacgtt cctccggtcc 87540 tgccgaacgc atacatgccc tattatctca gggagtatgt gacgcggctg gtcaacgggt 87600 tcaagccgct ggtgagccgg tccgctcgcc tttaccgcat cctgggggtt ctggtgcacc 87660 tgcggatccg gacccgggag gcctcctttg aggagtggct gcgatccaag gaagtggccc 87 720 tggactttgg cctgacggaa aggcttcgcg agcacgaagc ccagctggtg atcctggccc 87780 aggctctgga ccattacgac tgtctgatcc acagcacacc gcacacgctg gtcgagcggg 87840 ggctgcaatc ggccctgaag tatgaggagt tttacctaaa gcgctttggc gggcactaca 87900 tggagtccgt cttccagatg tacacccgca tcgccggctt tttggcctgc cgggccacgc 87960 gcggcatgcg ccacatcgcc ctggggcgag aggggtcgtg gtgggaaatg ttcaagttct 88020 ttttccaccg cctctacgac caccagatcg taccgtcgac ccccgccatg ctgaacctgg 88080 ggacccgcaa ctactacacc tccagctgct acctggtaaa cccccaggcc accacaaaca 88 140 aggcgaccct gcgggccatc accagcaacg tcagcgccat cctcgcccgc aacgggggca 88200 tcgggctatg cgtgcaggcg tttaacgact ccggccccgg gaccgctagc gtcatacccg 88260 ccctcaaggt cctcgactcg ctggtggcgg cgcacaacaa agagagcgcg cgtccaaccg 88320 gcgcgtgcgt gtacctggag ccgtggcaca ccgacgtgcg ggccgtgctc cggatgaagg 88380 gggtcctcgc cggcgaagag gcccagcgct gcgacaatat cttcagcgcc ctctggatgc 88440 cagacctgtt tttcaagcgc ctgattcgcc acctggacgg cgagaagaac gtcacatgga 88500 ccctgttcga ccgggacacc agcatgtcgc tcgccgactt tcacggggag gagttcgaga 88560 agctctacca gcacctcgag gtcatggggt tcggcgagca gatacccatc caggagctgg 88620 cctatggcat tgtgcgcagt gcggccacga ccgggagccc cttcgtcatg ttcaaagacg 88680 cggtgaaccg ccactacatc tacgacaccc agggggcggc catcgccggc tccaacctct 88740 gcaccgagat cgtccatccg gcctccaagc gatccagtgg ggtctgcaat ctgggaagcg 88800 tgaatctggc ccgatgcgtc tccaggcaga cgtttgactt tgggcggctc cgcgacgccg 88860 tgcaggcgtg cgtgctgatg gtgaacatca tgatcgacag cacgctacaa cccacgcccc 88920 agtgcacccg cggcaacgac aacctgcggt ccatgggaat cggcatgcag ggcctgcaca 88980 cggcctgcct gaagctgggg ctggatctgg agtctgtcga atttcaggac ctgaacaaac 89040 acatcgccga ggtgatgctg ctgtcggcga tgaagaccag caacgcgctg tgcgttcgcg 89 100 gggcccgtcc cttcaaccac tttaagcgca gcatgtatcg cgccggccgc tttcactggg 89 160 agcgctttcc ggacgcccgg ccgcggtacg agggcgagtg ggagatgcta cgccagagca 89220 tgatgaaaca cggcctgcgc aacagccagt ttgtcgcgct gatgcccacc gccgcctcgg 89280 cgcagatctc ggacgtcagc gagggctttg cccccctgtt caccaacctg ttcagcaagg 89340 tgacccggga cggcgagacg ctgcgcccca acacgctcct gctaaaggaa ctggaacgca 89400 cgtttagcgg gaagcgcctc ctggaggtga tggacagtct cgacgccaag cagtggtccg 89460 tggcgcaggc gctcccgtgc ctggagccca cccaccccct ccggcgattc aagaccgcgt 89520 ttgactacga ccagaagttg ctgatcgacc tgtgtgcgga ccgcgccccc tacgtcgacc 89580 atagccaatc catgaccctg tatgtcacgg agaaggcgga cgggaccctc ccagcctcca 89640 ccctggtccg ccttctggtc cacgcatata agcgcggact aaaaacaggg atgtactact 89700 gcaaggttcg caaggcgacc aacagcgggg tctttggcgg cgacgacaac attgtctgca 89760 cgagctgcgc gctgtgaccg acaaaccccc tccgcgccag gcccgccgcc actgtcgtcg 89820 ccgtcccacg cgctcccccg ctgccatgga ttccgcggcc ccagccctct cccccgctct 89880 gacggcccat acgggccaga gcgcgccggc ggacctggcg atccagattc caaagtgccc 89940 cgaccccgag aggtacttct acacctccca gtgtcccgac attaaccacc tgcgctccct 90000 cagcatcctt aaccgctggc tggaaaccga gcttgttttc gtgggggacg aggaggacgt 90060 ctccaagctt tccgagggcg agctcagctt ttaccgcttc ctcttcgctt tcctgtcggc 90 120 cgccgacgac ctggttacgg aaaacctggg cggcctctcc ggcctgtttg agcagaagga 90180 cattctccac tactacgtgg agcaggaatg catcgaagtc gtacactcgc gcgtgtacaa 90240 catcatccag ctggtgcttt ttcacaacaa cgaccaggcg cgccgcgagt acgtggccgg 90300 caccatcaac cacccggcca tccgcgccaa ggtggactgg ctggaagcgc gggtgcggga 90360 atgcgcctcc gttccggaaa agttcatcct catgatcctc atcgagggca tcttttttgc 90420 cgcctcgttt gccgccatcg cctaccttcg caccaacaac cttctgcggg tcacctgcca 90480 gtcaaacgac ctcatcagcc gggacgaggc cgtgcacacg acggcctcgt gttacatcta 90540 caacaactac ctcggcgggc acgccaagcc cccgcccgac cgcgtgtacg ggctgttccg 90600 ccaggcggtc gagatcgaga tcggatttat ccgatcccag gcgccgacgg acagccatat 90660 cctgagcccg gcggcgctgg cggccatcga aaactacgtg cgattcagcg cggatcgcct 90720 gttgggcctt atccacatga agccactgtt ttccgcccca ccccccgacg ccagctttcc 90780 gctgagcctc atgtccaccg acaaacacac caattttttc gagtgtcgca gcacctccta 90840 cgccggggcg gtcgtcaacg atctgtgagg gtcgcggcgc gcttctaccc gtgtttgccc 90900 ataataaacc tctgaaccaa actttgggtc tcattgtgat tcttgtcagg gacgcggggg 90960 tgggagagga taaaaggcgg cgcaaaaagc agtaaccagg tccgtccaga ttctgagggc 91020 ataggatacc ataattttat tggtgggtcg tttgttcggg gacaagcgcg ctcgtctgac 91080 gtttgggcta ctcgtcccag aatttggcca ggacgtcctt gtagaacgcg ggtggggggg 91 140 cctgggtccg cagctgctcc agaaacctgt cggcgatatc aggggccgtg atatgccggg 91200 tcacaataga tcgcgccagg ttttcgtcgc ggatgtcctg gtagataggc aggcgtttca 91260 gaagagtcca cggcccccgc tccttggggc cgataagcga tatgacgtac ttaatgtagc 91320 ggtgttccac cagctcggtg atggtcatgg gatcggggag ccagtccagg gactctgggg 91380 cgtcgtggat gacgtggcgt cgccggctgg ccacataact gcggtgctct tccagcagct 91440 gcgcgttcgg gacctggacg agctcgggcg gggtgagtat ctccgaggag gacgacctgg 91500 ggccggggtg gcccccggta acgtcccggg gatccagggg gaggtcctcg tcgtcttcgt 91560 atccgccggc gatctgttgg gttagaattt cggtccacga gacgcgcatc tcggtgccgc 91620 cggcggccgg cggcaaaggg ggcctggttt ccgtggagcg cgagctggtg tgttcccggc 91680 ggatggcccg ccgggtctga gagcgactcg ggggggtcca gtgacattcg cgcagcacat 91740 cctccacgga ggcgtaggtg ttattgggat ggaggtcggt gtggcagcgg acaaagaggg 91800 ccaggaactg ggggtagctc atcttaaagt actttagtat atcgcgacag ttgatcgtgg 91860 gaatgtagca ggcgctaata tccaacacaa tatcacagcc catcaacagg aggtcagtgt 91920 ctgtggtgta cacgtacgcg accgtgttgg tgtgatagag gttggcgcag gcatcgtccg 91980 cctccagctg acccgagtta atgtaggcgt accccagggc ccggagaacg cgaatacaga 92040 acagatgcgc cagacgcagg gccggcttcg agggcgcggc ggacggcagc gcggctccgg 92 100 acccggccgt cccccgggtc cccgaggcca gagaggtgcc gcgccggcgc atgttggaaa 92160 aggcagagct gggtctggag tcggtgatgg gggaaggcgg tggagaggcg tccacgtcac 92220 tggcctcctc gtccgtccgg cattgggccg tcgtgcgggc caggatggcc ttggctccaa 92280 acacaaccgg ctccatacaa ttgaccccgc gatcggtaac gaagatgggg aaaagggact 92340 tttgggtaaa cacctttaat aagcgacaga ggcagtgtag cgtaatggcc tcgcggtcgt 92400 aactggggta tcggcgctga tatttgacca ccaacgtgta catgacgttc cacaggtcca 92460 cggcgatggg ggtgaagtac ccggccgggg ccccaaggcc ctggcgcttg accagatggt 92520 gtgtgtgggc aaacttcatc atcccgaaca aacccatgtc aggtcgattg taactgcgga 92580 tcggcctaac taaggcgtgg ttggtgcgac ggtccgggac acccgagcct gtctctctgt 92640 gtatggtgac ccagacaaca acaccgacac aagaggacaa taatccgtta ggggacgctc 92700 tttataattt cgatggccca actccacgcg gattggtgca gcaccctgca tgcgccggtg 92760 tgggccaaac ttccccccgc tcattgcctc ttccaaaagg gtgtggccta acgagctggg 92820 ggcgtattta atcaggctag cgcggcgggc ctgccgtagt ttctggctcg gtgagcgacg 92880 gtccggttgc ttgggtcccc tggctgccag caaaacccca ccctcgcagc ggcatacgcc 92940 ccctccgcgt cccgcacccg agaccccggc ccggctgccc tcaccaccga agcccacctc 93000 gtcactgtgg ggtgttccca gcccgcattg ggatgacgga ttcccctggc ggtgtggccc 93060 ccgcctcccc cgtggaggac gcgtcggacg cgtccctcgg gcagccggag gagggggcgc 93 120 cctgccaggt ggtcctgcag ggcgccgaac ttaatggaat cctacaggcg tttgccccgc 93180 tgcgcacgag ccttctggac tcgcttctgg ttatgggcga ccggggcatc cttatccata 93240 acacgatctt tggggagcag gtgttcctgc ccctggaaca ctcgcaattc agtcggtatc 93300 gctggcgcgg acccacggcg gcgttcctgt ctctcgtgga ccagaagcgc tccctcctga 93360 gcgtgtttcg cgccaaccag tacccggacc tacgtcgggt ggagttggcg atcacgggcc 93420 aggccccgtt tcgcacgctg gttcagcgca tatggacgac gacgtccgac ggcgaggccg 93480 ttgagctagc cagcgagacg ctgatgaagc gcgaactgac gagctttgtg gtgctggttc 93540 cccagggaac ccccgacgtt cagttgcgcc tgacgaggcc gcagctcacc aaggtcctta 93600 acgcgaccgg ggccgatagt gccacgccca ccacgttcga gctcggggtt aacggcaaat 93660 tttccgtgtt caccacgagt acctgcgtca catttgctgc ccgcgaggag ggcgtgtcgt 93720 ccagcaccag cacccaggtc cagatcctgt ccaacgcgct caccaaggcg ggccaggcgg 93780 ccgccaacgc caagacggtg tacggggaaa atacccatcg caccttctct gtggtcgtcg 93840 acgattgcag catgcgggcg gtgctccggc gactgcaggt cgccgggggc accctcaagt 93900 tcttcctcac gacccccgtc cccagtctgt gcgtcaccgc caccggtccc aacgcggtat 93960 cggcggtatt tctcctgaaa ccccagaaga tttgcctgga ctggctgggt catagccagg 94020 ggtctccttc agccgggagc tcggcctccc gggcctctgg gagcgagcca acagacagcc 94080 aggactccgc gtcggacgcg gtcagccacg gcgatccgga agacctcgat ggcgctgccc 94140 gggcgggaga ggcgggggcc tcgcacgcct gtccgatgcc gtcgtcgacc acgcgggtca 94200 ctcccacgac caagcggggg cgctcggggg gcgaggatgc gcgcgcggac acggccctaa 94260 agaaacctaa gacggggtcg cccaccgcac ccccgcccac agatccagtc cccctggaca 94320 cggaggacga ctccgatgcg gcggacggga cggcggcccg tcccgccgct ccagacgccc 94380 ggagcggaag ccgttacgcg tgttactttc gcgacctccc gaccggagaa gcaagccccg 94440 gcgccttctc cgccttccgg gggggccccc aaaccccgta tggttttgga ttcccctgac 94500 ggggcggggc cttggcggcc gcccaactct cgcaccatcc cgggttaatg taaataaact 94560 tggtattgcc caacactctc ccgcgtgtcg cgtgtggttc atgtgtgtgc ctggcgtccc 94620 ccaccctcgg gttcgtgtat ttcctttccc tgtccttata aaagccgtat gtggggcgct 94680 gacggaacca ccccgcgtgc catcacggcc aaggcgcggg atgctccgca acgacagcca 94740 ccgggccgcg tccccggagg acggccaggg acgggtcgac gacggacggc cacacctcgc 94800 gtgcgtgggg gccctggcgc gggggttcat gcatatctgg cttcaggccg ccacgctggg 94860 ttttgcggga tcggtcgtta tgtcgcgcgg gccgtacgcg aatgccgcgt ctggggcgtt 94920 cgccgtcggg tgcgccgtgc tgggctttat gcgcgcaccc cctcccctcg cgcggcccac 94980 cgcgcggata tacgcctggc tcaaactggc ggccggtgga gcggcccttg ttctgtggag 95040 tctcggggag cccggaacgc agccgggggc cccgggcccg gccacccagt gcctggcgct 95 100 gggcgccgcc tatgcggcgc tcctggtgct cgccgatgac gtctatccgc tctttctcct 95 160 cgccccgggg cccctgttcg tcggcaccct ggggatggtc gtcggcgggc tgacgatcgg 95220 aggcagcgcg cgctactggt ggatcggtgg gcccgccgcg gccgccttgg ccgcggcggt 95280 gttggcgggc ccgggggcga ccaccgccag ggactgcttc tccagggcgt gccccgacca 95340 ccgccgcgtc tgcgtcatcg tcgcaggcga gtctgtttcc cgccgccccc cggaggaccc 95400 agagcgaccc ggggaccccg ggccaccgtc ccccccgaca ccccaacgat cccaggggcc 95460 gccggccgat gaggtcgcac cggccggggt agcgcggccc gaaaacgtct gggtgcccgt 95520 ggtcaccttt ctgggggcgg gcgcgctcgc cgtcaagacg gtgcgagaac atgcccggga 95580 aacgccgggc ccgggcctgc cgctgtggcc ccaggtgttt ctcggaggcc atgtggcggt 95640 ggccctgacg gagctgtgtc aggcgcttat gccctgggac cttacggacc cgctgctgtt 95700 tgttcacgcc ggactgcagg tcatcaacct cgggttggtg tttcggtttt ccgaggttgt 95760 cgtgtatgcg gcgctagggg gtgccgtgtg gatttcgttg gcgcaggtgc tggggctccg 95820 gcgtcgcctg cacaggaagg accccgggga cggggcccgg ttggcggcga cgcttcgggg 95880 cctcttcttc tccgtgtacg cgctggggtt tggggtgggg gcgctgctgt gccctccggg 95940 gtcaacgggc gggtggtcgg gcgattgata tatttttcaa taaaaggcat tagtcccgaa 96000 gaccgccggt gtgtgatgat ttcgccataa cacccaaacc ccggatgggg cccgggtata 96060 aattccggaa ggggacacgg gctaccctca ctaccgaggg cgcttggtcg ggaggccgca 96120 tcgaacgcac acccccatcc ggtggtccgt gtggaggtcg tttttcagtg cccggtctcg 96180 ctttgccggg aacgctagcc gatccctcgc gagggggagg cgtcgggcat ggccccgggg 96240 cgggtgggcc ttgccgtggt cctgtggagc ctgttgtggc tcggggcggg ggtggccggg 96300 ggctcggaaa ctgcctccac cgggcccacg atcaccgcgg gagcggtgac gaacgcgagc 96360 gaggccccca catcggggtc ccccgggtca gccgccagcc cggaagtcac ccccacatcg 96420 accccaaacc ccaacaatgt cacacaaaac aaaaccaccc ccaccgagcc ggccagcccc 96480 ccaacaaccc ccaagcccac ctccacgccc aaaagccccc ccacgtccac ccccgacccc 96540 aaacccaaga acaacaccac ccccgccaag tcgggccgcc ccactaaacc ccccgggccc 96600 gtgtggtgcg accgccgcga cccattggcc cggtacggct cgcgggtgca gatccgatgc 96660 cggtttcgga attccacccg catggagttc cgcctccaga tatggcgtta ctccatgggt 96720 ccgtcccccc caatcgctcc ggctcccgac ctagaggagg tcctgacgaa catcaccgcc 96780 ccacccgggg gactcctggt gtacgacagc gcccccaacc tgacggaccc ccacgtgctc 96840 tgggcggagg gggccggccc gggcgccgac cctccgttgt attctgtcac cgggccgctg 96900 ccgacccagc ggctgattat cggcgaggtg acgcccgcga cccagggaat gtattacttg 96960 gcctggggcc ggatggacag cccgcacgag tacgggacgt gggtgcgcgt ccgcatgttc 97020 cgccccccgt ctctgaccct ccagccccac gcggtgatgg agggtcagcc gttcaaggcg 97080 acgtgcacgg ccgccgccta ctacccgcgt aaccccgtgg agtttgtctg gttcgaggac 97 140 gaccgccagg tgtttaaccc gggccagatc gacacgcaga cgcacgagca ccccgacggg 97200 ttcaccacag tctctaccgt gacctccgag gctgtcggcg gccaggtccc cccgcggacc 97260 ttcacctgcc agatgacgtg gcaccgcgac tccgtgatgt tctcgcgacg caatgccacc 97320 gggctggccc tggtgctgcc gcggccaacc atcaccatgg aatttggggt ccggcatgtg 97380 gtctgcacgg ccggctgcgt ccccgagggc gtgacgtttg cctggttcct gggggacgac 97440 ccctcaccgg cggctaagtc ggccgttacg gcccaggagt cgtgcgacca ccccgggctg 97500 gctacggtcc ggtccaccct gcccatttcg tacgactaca gcgagtacat ctgtcggttg 97560 accggatatc cggccgggat tcccgttcta gagcaccacg gcagtcacca gcccccaccc 97620 agggacccca ccgagcggca ggtgatcgag gcgatcgagt gggtggggat tggaatcggg 97680 gttctcgcgg cgggggtcct ggtcgtaacg gcaatcgtgt acgtcgtccg cacatcacag 97740 tcgcggcagc gtcatcggcg gtaacgcgag acccccccgt taccttttta atatctatat 97800 agtttggtcc ccctctatcc cgcccaccgc tgggcgctat aaagccgcca ccctctcttc 97860 cctcaggtca tccttggtcg atcccgaacg acacacggcg tggagcaaaa cgcctccccc 97920 tgagccgctt tcctaccaac acaacggcat gcctctgcgg gcatcggaac acgcctaccg 97980 gcccctgggc cccgggacac cccccatgcg ggctcggctc cccgccgcgg cctgggttgg 98040 cgtcgggacc atcatcgggg gagttgtgat cattgccgcg ttggtcctcg tgccctcgcg 98 100 ggcctcgtgg gcactttccc catgcgacag cggatggcac gagttcaacc tcgggtgcat 98 160 atcctgggat ccgaccccca tggagcacga gcaggcggtc ggcggctgta gcgccccggc 98220 gaccctgatc ccccgcgcgg ctgccaaaca gctggccgcc gtcgcacgcg tccagtcggc 98280 aagatcctcg ggctactggt gggtgagcgg agacggcatt cgggcctgcc tgcggctcgt 98340 cgacggcgtc ggcggtattg accagttttg cgaggagccc gcccttcgca tatgctacta 98400 tccccgcagt cccgggggct ttgttcagtt tgtaacttcg acccgcaacg cgctggggct 98460 gccgtgaggc gcgtgtactg cggtctgtct cgtctcctct tctccccttc cctccccctc 98520 cgcatcccag gatcacaccg gccaacgagg gttggggggg tccggcacgg acccaaaata 98580 ataaacacac aatcacgtgc gataaaaaga acacgcggtc ccctgtggtg tttttggtta 98640 tttttattaa atctcgtcga caaacagggg gaaaggggcg tggtctagcg acggcagcac 98700 gggcggaggc gttcaccggc tccggcgtcc ttcgcgttta agcttggtca ggagggcgct 98760 cagggcggcg acgttggtcg ggccgtcgtt ggtcagggcg ttggctcgat ggcgggcgag 98820 gacgggcgag gggctcaacg gcgggggcgg gggtccggtg cggcccgggg gggaaaatag 98880 ggcggatccc ccccagtcgt acaggggatt ttccgcctca atgtacgggg aggccggcgc 98940 tgcattcgcc gtgttcacgc agacgttttc gtagacccgc atccatggta tttcctcgta 99000 gacacgcccc ccgtcctcgc tcacggtctc gtatattgac tcgtcgtcct cgtagggggc 99060 gtgccgttcg cgggccgagg cggcgtgggt ggctttgcgg cgggcgtcgt cgtcgtcgtc 99120 gtcggccgtc agatacgtgg cttccatctg gtcgggttct ccctccgggg cgggtcccca 99180 cacccgtggc cgatcgaggc tccccagaga cgcgcgccgg acaagaaggg ggcacgtcgc 99240 cgccggcggt cgcctgtcgg gtcccgcgac gttacgggcc gggaggcgcg ggggcacctc 99300 ccccatgtgc gtgtaatacg tggccggctg tgcggccgca gcggggggct cggcgaccgg 99360 gtcgtccgca tccggaagcg ggggccccgc gccgtccgca cggcgcctcc ggaaccgccg 99420 ggtggacggc gcgggggtcg agtgtaggcg aggtcggggg aggggcgggg gctcgttgtc 99480 gcgccgcgcc cgctgaatct tttcccgaca ggtcccaccc cccgcgcgat gcccccccgg 99540 gccgcgggcc atgtcgtccg ggggaggccc cgcggaccac gtcgtccggc gagacgccac 99600 gagccgcagg atggactcgt agtggagcga cggcgccccg ctgcggagca gatccgcggc 99660 cagggcggcc ccgaaccaag ccttgatgct caactccatc cgggcccagc tgggggcggt 99720 catcgtgggg aacagggggg cggtggtccg acagaaacgc tcctggctgt ccaccgcggc 99780 ccgcagatac tcgttgttca ggctgtcggt ggcccagacg ccgtacccgg tgagggtcgc 99840 gttgatgata tactgggcgt ggtgatggac gatcgacaga acctccaccg tggataccac 99900 ggtatccacg gtcccgtacg taccgccgct ccgcttgccg gtctgccaca ggttggctag 99960 gcacgtcagg tggcccagga cgtcgctgac cgccgccctg agcgccatgc actgcatgga 100020 gccggtcgtg ccgctgggac cccggtccag atggcgcgcg aacgtttccg cgggcgcctc 100080 cgggctgccg ccgagcggga ggaaccggcg attggaggga ctcagccggt gacatacgtg 100 140 cttgtccgtc gtccacagca tccaggacgc ccaccggtac agcacggaga cgtaggccag 100 200 gagctcgttg agccgcagtg cggtgtcggt gctggggcgg cttgggtccg ccgggcgcat 100 260 aaagaacatg tactgctgaa tccgatggag ggcgtcgcgc aggccggcca cggtggcggc 100 320 gtacttggcc gccgcggccc cgctcttgaa cggggtgcgc gccagcagct ttggcgccag 100 380 ggtgggccgc agcagcacgt gaaggctggg gtcgcagtcg cccacggggt cctcggggac 100440 gtccaggccg ctgggcacca ccgtctgcag gtacttccag tactgcgtga ggatggcgcg 100 500 gctcaactgg ccgccgggca gctccacctc gcccagcgcc tgggtggcgg ccgaagcgta 100560 gtgccggatg tactcgtagt gcgggtcgct ggcgagcccg tccacgatca aactctcggg 100620 aaccgtgttg tgttgccgcg cggccaaccg gacgctgcga tcggtgcagg tcagaaacgc 100680 cggctgcgcg tcgtcggagc gctgccgcaa ggcgcccacg gccgcgctaa ggagcccctc 100740 cggggtgggg agcagacacc cgccgaagat gcgccgctcg ggaacgcccg cgttgtcgcc 100 800 gcggatcagg ttggcaggcg tcaggcaccg cgccagccgc agggagctcg cgccgcgcgt 100860 ccggcgctgc atggtgacgc ccgttcggtc gggacccgcc ggtcggagtt atgccgcgtc 100920 cagggccatc ggggcgcttt ttatcgggag gagcttatgg gcgtggcggg cctcccagcc 100980 cggtcgcgcg cctccccgac acgtgcgccc gcagggcggc ggccccctcg tctcccatca 101040 gcagtttcct aaactgggac atgatgtcca ccacgcggac ccgcgggccc aacacggacc 101100 cgccgcttac gggggcgggg gggaagggct ccaggtcctt gagcagaaag gcggggtctg 101 160 ccgtcccgga cacgggggcc cggggcgcgg aggaggcggg gcgcagatcc acgtgctccg 101220 cggccgcgcg gacgtccgcc cagaacttgg cgggggtggt gcgcgcgtac aggggctggg 101280 tcgctcggag gacacacgcg tagcgcaggg gggtgtacgt gcccacctcg ggggccgtga 101340 atcccccgtc aaacgcggcc agtgtcacgc acgccaccac ggtgtcggca aagcccagca 101400 gccgctgcag gacgagcccg gcggccagaa tggcgcgcgt ggtcgcagcg tcgtcccggc 101460 gccggtgcgc gtccccgcac gcccgggcgt actttaaggt cactgtcgcc agggccgtgt 101520 gcagcgcgta caccgcagcg cccagcacgg cgttgagccc gctgttggcg agcagccggc 101580 gcgctgcggt gtcgcccagc gcctcgtgct cggcccccac gaccgcgggg cttcccaggg 101640 gcagggcgcg aaacagctcc tcccgcgcca cgtccgcaaa ggcggggtgg tgcacgtgcg 101700 ggtgcaggcg cgcccccacg accaccgaga gccactggac cgtctgctcc gccatcaccg 101760 ccaacacatc cagcacgcgc cccaggaagg cggcctcccg cgtcaaaacg caccggacgg 101820 cgtcgggatt gaagcgggcg agcagggccc cggtggccag gtacgtcatg cggccggcat 101880 agcgggcggc cacgcgacag tcgcggtcca gcagcgcgcg caccccgggc cagtacagca 101940 gggaccccag cgagctgcga aacaccgcgg cgtcggggcc ggattggggg gacactaacc 102000 cccccgcgct cagtaacggc acggccgcgg ccccgacggg acgcaacgcc gtgaggctcg 102060 cgaactgccg cctcagctcg gcagccctgt cgtccaggtc cgacccgcgc gcctctgcgt 102 120 gaaggcgcgt cccgcacacc cacccgttga tggccagccg cacgacggca tccgccaaaa 102 180 agctcatcgc ctgggcgggg ctggtttttg ttcgacgatc cgtcaggtca agaatcccat 102 240 cgcccgtgat ataccaggcc aacgcctcgc cctgctgcag ggtttggcgg aaaaacaccg 102 300 cggggttgtc gggggaggcg aagtgcatga cccccacgcg cgataacccg aacgcgctat 102360 ccggacacgg gtaaaacccg gccggatgcc ccagggctag ggcggagcgc acggactcgt 102420 cccacacggc aacctgaggg gccagtcgat ccaacgggaa tgccgcccgg agctccgggc 102480 ccggcacgcg tccctccaga acctccacct tgggcgggga acgggccccg ccgccgtcct 102540 ccggcccgac gtcttccggg tagtcgtcct cctcgtactg cagttcctct aggaacagcg 102 600 gcgacggcgc cacccgcgaa ccgccgaccc gccccaaaat agcccgcgcg tcgacgggac 102660 ccaggtatcc cccctgccgg gcctgcggag gaccgcgggg aacctcatca tcatcgtcca 102 720 ggcgaccgcg caccgactgg ctacgggccg catcgggccc ggggcgctgc cgggacgctc 102780 ggcgatggga tgagggcggg gcttccgacg cgcgccgtcg tcgggctcgc gggccttccc 102840 gtcgacggcg cacgggcggc tcgtcgcccg ccatctcctc cagagcctct agctcgctgt 102900 cgtcatcccc gcggaacacc gcacgcaggt accccatgaa ccccacccca tcgcccgctg 102960 gctcgtccgc cacgggcgag gcgcgggggc gggtggatgc gcgcctcctg cgccccgcgg 103020 gttcgcgagc cgacatggtg gcgatagacg cgggttatcg gatgtccgct accccccaaa 103080 aaagaaaaag accccacagc gcggatggag gtcggggtag gtgccgccgg accccctcgc 103 140 gatgggaatg gacgggagcg acggggccgg cgcaaaaaac gcagtatctc ccgcgaaggc 103 200 tacccgccgc cccagccccc ggccaaatgc ggaaacggtc ccgcgctctc gcctttatac 103260 gcgggccgcc ctgcgacaca atcacccgtc cgtggtttcg aatctacacg acaggcccgc 103320 agacgcggct aacacacacg ccggcaaccc agaccccagt gggttggttg cgcggtcccg 103380 tctcctggct agttctttcc cccaccacca aataatcaga cgacaaccgc aggtttttgt 103440 aatgtatgtg ctcgtgttta ttgtggatac gaaccgggga cgggagggga aaacccagac 103500 gggggatgcg ggtccggtcg cgccccctac ccaccgtact cgtcaattcc aagggcatcg 103560 gtaaacatct gctcaaactc gaagtcggcc atatccagag cgccgtaggg ggcggagtcg 103620 tggggggtaa atcccggacc cggggaatcc ccgtccccca acatgtccag atcgaaatcg 103680 tctagcgcgt cggcatgcgc catcgccacg tcctcgccgt ctaagtggag ctcgtccccc 103740 aggctgacat cggtcggggg ggccgtcgac agtctgcgcg tgtgtcccgc ggggagaaag 103800 gacaggcgcg gagccgccag ccccgcctct tcgggggcgt cgtcgtccgg gagatcgagc 103860 aggccctcga tggtagaccc gtaattgttt ttcgtacgcg cgcggctgta cgcgtgttcc 103920 cgcatgaccg cctcggaggg cgaggtcgtg aagctggaat acgagtccaa cttcgcccga 103980 atcaacacca taaagtaccc agaggcgcgg gcctggttgc catgcagggt gggaggggtc 104040 gtcaacggcg cccctggctc ctccgtagcc gcgctgcgca ccagcgggag gttaaggtgc 104 100 tcgcgaatgt ggtttagctc ccgcagccgg cgggcctcga ttggcactcc ccggacggtg 104 160 agcgctccgt tgacgaacat gaagggctgg aacagacccg ccaactgacg ccagctctcc 104 220 aggtcgcaac agaggcagtc aaacaggtcg ggccgcatca tctgctcggc gtacgcggcc 104280 cataggatct cgcgggtcaa aaatagatac aaatgcaaaa acagaacacg cgccagacga 104340 gcggtctctc ggtagtacct gtccgcgatc gtggcgcgca gcatttctcc caggtcgcga 104 400 tcgcgtccgc gcatgtgcgc ctggcggtgc agctgccgga cgctggcgcg caggtaccgg 104460 tacagggccg agcagaagtt ggccaacacg gttcgatagc tctcctcccg cgcccgtagc 104520 tcggcgtgga agaaacgaga gagcgcttcg tagtagagcc cgaggccgtc gcgggtggcc 104580 ggaagcgtcg ggaaggccac gtcgccgtgg gcgcgaatgt cgatttgggc gcgttcgggg 104640 acgtacgcgt ccccccattc caccacatcg ctgggcagcg ttgataggaa tttacactcc 104700 cggtacaggt cggcgttggt cggtaacgcc gaaaacaaat cctcgttcca ggtatcgagc 104760 atggtacata gcgcggggcc cgcgctaaag cccaagtcgt cgaggagacg gttaaagagg 104820 gcggcggggg ggacgggcat gggcggggag ggcatgagct gggcctggct caggcgcccc 104880 gttgcgtaca gcggaggggc cgccggggtg tttttgggac ccccggccgg gcgggggggt 104940 ggtggcgaag cgccgtccgc gtccatgtcg gcaaacagct cgtcgaccaa gaggtccatt 105000 gggtggggtt gatacgggaa agacgatatc gggcttttga tgcgatcgtc cccgcccgcc 105060 cagagagtgt gggacgcccg acggcgcggg aagagaaaaa cccccaaacg cgttagagga 105 120 ccggacggac cttatggggg gaagtgggca gcgggaaccc cgtccgttcc cgaggaatga 105 180 cagcccgtgg tcgccacccc gcatttaagc aacccgcacg ggccgccccg tacctcgtga 105 240 cttcccccca cattggctcc tgtcacgtga aggcaaaccg agggcggctg tccaacccac 105 300 cccccgccac ccagtcacgg tccccgtcgg attgggaaac aaaggcacgc aacgccaaca 105360 ccgaatgaac ccctgttggt gctttattgt ctgggtacgg aagtttttca ctcgacgggc 105420 cgtctggggc gagaagcgga gcgggctggg gctcgaggtc gctcggtggg gcgcgacgcc 105 480 gcagaacgcc ctcgagtcgc cgtggccgcg tcgacgtcct gcaccacgtc tggattcacc 105540 aactcgttgg cgcgctgaat caggtttttg ccctcgcaga ccgtcacgcg gatggtggtg 105 600 atgccaagga gttcgttgag gtcttcgtct gtgcgcggac gcgacatgtc ccagagctgg 105660 accgccgcca tccgggcatg catggccgcc aggcgcccaa ccgcggcgca gaagacgcgc 105 720 ttgttaaagc cggccacccg gggggtccat ggcgcgtcgg ggtttggggg ggcggtgcta 105780 aagtgcagct ttctggccag cccctgcgcg ggtgtcttgg atcgggttgg cgccgtcgac 105840 gcgggggcgt ctgggagtgc ggcggattct ggctgggccg atttcctgcc gcgggtggtc 105900 tccgccgccg gggccgcggg ggccttagtc gccacccgct gggttcgggg ggcccggggg 105960 gcggtggtgg gtgtgcgtcc ggcccctccg gacccagcgg gcggcggagg cgcccgcgca 106020 ggccccgggg cggacaaaac cgccccggaa acgggacgcc gcgtccgggg gacctccggg 106080 tgttcgtcgt cttcggatga cgagcccccg tagagggcat aatccgactc gtcgtactgg 106 140 acgaaacgga cctcgcccct tgggcgcgcg cgtgtctgta gggcgccacg gcgggaggtg 106 200 tcaggcggac tatcgggact cgccatacat gaagacgggg tgtagtacag atcctcgtac 106 260 tcatcgcgcg gaacctcccg cggacccgac ttcacggagc ggcgagaggt catggttcca 106 320 cgaacacgct agggtcggat gcgcggacaa ttaggcctgg gttcggacgg cgggggtggt 106380 gcaggtgtgg agaggtcgag cgataggggc ggcccgggag agaagagagg gtccgcaaaa 106440 cccactgggg atgcgtgagt ggccctctgt gggcggtggg ggagagtctt ataggaagtg 106500 catataacca caacccatgg gtctaaccaa tccccagggg ccaagaaaca gacacgcccc 106560 aaacggtctc ggtttccgcg aggaagggga agtcctggga caccctccac ccccacccct 106620 caccccacac agggcgggtt caggcgtgcc cggcagccag tagcctctgg cagatctgac 106680 agacgtgtgc gataatacac acgcccatcg aggccatgcc tacataaaag ggcaccaggg 106740 cccccggggc agacatttgg ccagcgtttt gggtctcgca ccgcgcgccc ccgatcccat 106800 cgcgcccgcc ctcctcgccg ggcggctccc cgtgcgggcc cgcgtctccc gccgctaagg 106860 cgacgagcaa gacaaacaac aggcccgccc gacagaccct tctggggggg cccatcgtcc 106920 ctaacaggaa gatgagtcag tggggatccg gggcgatcct tgtccagccg gacagcttgg 106980 gtcgggggta cgatggcgac tggcacacgg ccgtcgctac tcgcgggggc ggagtcgtgc 107040 aactgaacct ggtcaacagg cgcgcggtgg cttttatgcc gaaggtcagc ggggactccg 107 100 gatgggccgt cgggcgcgtc tctctggacc tgcgaatggc tatgccggct gacttttgtg 107 160 cgattattca cgcccccgcg ctatccagcc cagggcacca cgtaatactg ggtcttatcg 107 220 actcggggta ccgcggaacc gttatggccg tggtcgtagc gcctaaaagg acgcgggaat 107280 ttgcccccgg gaccctgcgg gtcgacgtga cgttcctgga catcctggcg acccccccgg 107340 ccctcaccga gccgatttcc ctgcggcagt tcccgcaact ggcgcccccc cctccaaccg 107 400 gggccgggat acgcgcagat ccttggttgg agggggcgct cggggaccca agcgtgactc 107460 ctgccctacc ggcgcgacgc cgagggcggt ccctcgtcta tgccggcgag ctgacgccgg 107520 ttcagacgga acacggggac ggcgtacgag aagccatcgc cttccttcca aaacgcgagg 107580 aggatgccgg tttcgacatt gtcgtccgtc gcccggtcac cgtcccggca aacggcacca 107640 cggtcgtgca gccatccctc cgcatgctcc acgcggacgc cgggcccgcg gcctgctatg 107700 tgctggggcg gtcgtcgctc aacgcccgcg gcctcctggt cgttcctacg cgctggctcc 107760 ccgggcacgt atgtgcgttt gttgtttaca accttacggg ggttcctgtg accctcgagg 107820 ccggcgccaa ggtcgcccag ctcctggttg cgggggcgga cgctcttcct tggatccccc 107880 cggacaactt tcacgggacc aaagcgcttc gaaactaccc caggggtgtt ccggactcaa 107940 ccgccgaacc caggaacccg ccgctcctgg tgtttacgaa cgagtttgac gcggaggccc 108000 ccccgagcga gcgcgggacc gggggttttg gctctaccgg tatttagccc atagcttggg 108060 gttcgttccg ggcaataaaa aacgtttgta tctcatcttt cctgtgtgta gttgtttctg 108 120 ttggatgcct gtgggtctat cacacccgcc cctccatccc acaaacacag aacacacggg 108 180 ttggatgaaa acacgcattt attgacccaa aacacacgga gctgctcgag atgggccagg 108 240 gcgaggtgcg gttggggagg ctgtaggtct gggaacggac acgcggggac acgattccgg 108 300 tttggggtcc gggagggcgt cgccgtttcg ggcggcaggc gccagcgtaa cctccggggg 108360 cggcgtgtgg gggtgcccca aggagggcgc ctcggtcacc ccaagccccc ccgagcgggt 108420 tcccccggca accccgaagg cggagaggcc aagggcccgt tcggcgatgg ccacatcctc 108480 catgaccacg tcgctctcgg ccatgctccg aatagcctgg gagacgagca catccgcgga 108540 cttgtcagcc gcccccacgg acatgtacat ctgcaggatg gtggccatac acgtgtccgc 108600 caggcgccgc atcttgtcct gatgggccgc cacggccccg tcgatcgtgg gggcctcgag 108660 cccggggtgg tggcgcgcca gtcgttctag gttcaccatg caggcgtggt acgtgcgggc 108 720 caaggcgcgg gccttcacga ggcgtcgggt gtcgtccagg gaccccaggg cgtcatcgag 108780 cgtgatgggg gcgggaagta gcgcgttaac gaccaccagg gcctcctgca gccgcggctc 108840 cgcctccgag ggcggaacgg ccgcgcggat catctcatat tgttcctcgg ggcgcgctcc 108900 ccagccacat atagccccga gaagagaagc catcgcgggc gggtactggc ccttgggcgc 108960 gcggacgcaa tggggcagga agacgggaac cgcggggaga ggcgggcggc cgggactccc 109020 gtggaggtga ccgcgcttta tgcgaccgac gggtgcgtta ttacctcttc gatcgccctc 109080 ctcacaaact ctctactggg ggccgagccg gtttatatat tcagctacga cgcatacacg 109140 cacgatggcc gtgccgacgg gcccacggag caagacaggt tcgaagagag tcgggcgctc 109200 taccaagcgt cgggcgggct aaatggcgac tccttccgag taaccttttg tttattgggg 109 260 acggaagtgg gtgggaccca ccaggcccgc gggcgaaccc gacccatgtt cgtctgtcgc 109320 ttcgagcgag cggacgacgt cgccgcgcta caggacgccc tggcgcacgg gaccccgcta 109380 caaccggacc acatcgccgc caccctggac gcggaggcca cgttcgcgct gcatgcgaac 109440 atgatcctgg ctctcaccgt ggccgtcaac aacgccagcc cccgcaccgg acgcgacgcc 109500 gccgcggcgc agtatgatca gggcgcgtcc ctacgctcgc tcgtggggcg cacgtccctg 109560 ggacaacgcg gccttaccac gctatacgtc caccacgagg cgcgcgtgct ggccgcgtac 109620 cgcagggcgt attatggaag cgcgcagagt cccttctggt ttcttagcaa attcgggcct 109680 gacgaaaaaa gcctggtgct caccactcgg tactacctgc ttcaggccca gcgtctgggg 109740 ggcgcggggg ccacgtacga cctgcaggcc atcaaggaca tctgcgccac ctacgcgatt 109800 ccccacgccc cccgccccga caccgtcagc gccgcgtccc tgacctcgtt tgccgccatc 109860 acgcggttct gttgcacgag ccagtacgcc cgcggggccg cggcggccgg gtttccgctt 109920 tacgtggagc gccgtattgc ggccgacgtc cgcgagacca gtgcgctgga gaagttcata 109980 acccacgatc gcagttgcct gcgcgtgtcc gaccgtgaat tcattacgta catttacctg 110040 gcccattttg agtgtttcag ccccccgcgc ctagccacgc atcttcgggc cgtgacgacc 110 100 caggacccca accccgcggc caacacggag cagccctcgc ccctgggcag ggaggccgtg 110 160 gaacaatttt tttgccacgt gcgcgcccaa ctgaatatcg gggagtacgt caaacacaac 110 220 gtgacccccc gggagaccgt cctggatggc gatacggcca aggcctacct gcgcgctcgc 110 280 acgtacgcgc ccggggccct gacgcccgcc cccgcgtatt gcggggccgt ggactccgcc 110340 accaaaatga tggggcgttt ggcggacgcc gaaaagctcc tggtcccccg cgggtggccc 110 400 gcgtttgcgc ccgccagtcc cggggaggat acggcgggcg gcacgccgcc cccacagacc 110460 tgcggaatcg tcaagcgcct cctgagactg gccgccacgg aacaacagga caccacgccc 110 520 ccggcgatcg cggcgcttat ccgtaatgcg gcggtgcaga ctcccctgcc cgtctaccgg 110580 atatccatgg tccccacggg acaggcattt gccgcgctgg cctgggacga ctgggcccgc 110640 ataacgcggg acgctcgcct ggccgaagcg gtcgtgtccg ccgaagcggc ggcgcacccc 110 700 gaccacggcg cgctgggcag gcggctcacg gatcgcatcc gcgcccaggg ccccgtgatg 110 760 ccccctggcg gcctggatgc cggggggcag atgtacgtga atcgcaacga gatatttaac 110820 ggcgcgctgg caatcacaaa catcatcctg gatctcgaca tcgccctgaa ggagcccgtc 110880 ccctttcgcc ggctccacga ggccctgggc cactttaggc gcggggctct ggcggcggtt 110940 cagctcctgt ttcccgcggc ccgcgtggac cccgacgcat atccctgtta ttttttcaaa 111000 agcgcatgtc ggcccggccc ggcgtccgtg ggttccggca gcggactcgg caacgacgac 111060 gacggggact ggtttccctg ctacgacgac gccggtgatg aggagtgggc ggaggacccg 111 120 ggcgccatgg acacatccca cgatcccccg gacgacgagg ttgcctactt tgacctgtgc 111 180 cacgaagtcg gccccacggc ggaacctcgc gaaacggatt cgcccgtgtg ttcctgcacc 111 240 gacaagatcg gactgcgggt gtgcatgccc gtccccgccc cgtacgtcgt ccacggttct 111 300 ctaacgatgc ggggggtggc acgggtcatc cagcaggcgg tgctgttgga ccgagatttt 111360 gtggaggcca tcgggagcta cgtaaaaaac ttcctgttga tcgatacggg ggtgtacgcc 111420 cacggccaca gcctgcgttt gccgtatttt gccaaaatcg cccccgacgg gcctgcgtgc 111480 ggaaggctgc tgccagtgtt tgtgatcccc cccgcctgca aagacgttcc ggcgtttgtc 111540 gccgcgcacg ccgacccgcg gcgcttccat tttcacgccc cgcccaccta tctcgcttcc 111600 ccccgggaga tccgtgtcct gcacagcctg ggtggggact atgtgagctt ctttgaaagg 111660 aaggcgtccc gcaacgcgct ggaacacttt gggcgacgcg agaccctgac ggaggtcctg 111 720 ggtcggtaca acgtacagcc ggatgcgggg gggaccgtcg aggggttcgc atcggaactg 111780 ctggggcgga tagtcgcgtg catcgaaacc cactttcccg aacacgccgg cgaatatcag 111840 gccgtatccg tccggcgggc cgtcagtaag gacgactggg tcctcctaca gctagtcccc 111900 gttcgcggta ccctgcagca aagcctgtcg tgtctgcgct ttaagcacgg ccgggcgagt 111960 cgcgccacgg cgcggacatt cgtcgcgctg agcgtcgggg ccaacaaccg cctgtgcgtg 112020 tccttgtgtc agcagtgctt tgccgccaaa tgcgacagca accgcctgca cacgctgttt 112080 accattgacg ccggcacgcc atgctcgccg tccgttccct gcagcacctc tcaaccgtcg 112 140 tcttgataac ggcgtacggc ctcgtgctcg tgtggtacac cgtcttcggt gccagtccgc 112200 tgcaccgatg tatttacgcg gtacgcccca ccggcaccaa caacgacacc gccctcgtgt 112 260 ggatgaaaat gaaccagacc ctattgtttc tgggggcccc gacgcacccc cccaacgggg 112 320 gctggcgcaa ccacgcccat atctgctacg ccaatcttat cgcgggtagg gtcgtgccct 112380 tccaggtccc acccgacgcc acgaatcgtc ggatcatgaa cgtccacgag gcagttaact 112440 gtctggagac cctatggtac acacgggtgc gtctggtggt cgtagggtgg ttcctgtatc 112500 tggcgttcgt cgccctccac caacgccgat gtatgtttgg tgtcgtgagt cccgcccaca 112560 agatggtggc cccggccacc tacctcttga actacgcagg ccgcatcgta tcgagcgtgt 112620 tcctgcagta cccctacacg aaaattaccc gcctgctctg cgagctgtcg gtccagcggc 112680 aaaacctggt tcagttgttt gagacggacc cggtcacctt cttgtaccac cgccccgcca 112740 tcggggtcat cgtaggctgc gagttgatgc tacgctttgt ggccgtgggt ctcatcgtcg 112 800 gcaccgcttt catatcccgg ggggcatgtg cgatcacata ccccctgttt ctgaccatca 112860 ccacctggtg ttttgtctcc accatcggcc tgacagagct gtattgtatt ctgcggcggg 112920 gcccggcccc caagaacgca gacaaggccg ccgccccggg gcgatccaag gggctgtcgg 112980 gcgtctgcgg gcgctgttgt tccatcatcc tgtcgggcat cgcaatgcga ttgtgttata 113040 tcgccgtggt ggccggggtg gtgctcgtgg cgcttcacta cgagcaggag atccagaggc 113 100 gcctgtttga tgtatgacgt cacatccagg ccggcggaaa ccggaacggc atatgcaaac 113 160 tggaaactgt cctgtcttgg ggcccaccca cccgacgcgt catatgtaaa tgaaaatcgt 113220 tcccccgagg ccatgtgtag cctggatccc aacgaccccg cccatgggtc ccaattggcc 113280 gtcccgttac caagaccaac ccagccagcg tatccacccc cgcccgggtc cccgcggaag 113340 cggaacggtg tatgtgatat gctaattaaa tacatgccac gtacttatgg tgtctgattg 113400 gtccttgtct gtgccggagg tggggcgggg gccccgcccg gggggcggaa ctaggagggg 113460 tttgggagag ccggccccgg caccacgggt ataaggacat ccaccacccg gccggtggtg 113520 gtgtgcagcc gtgttccaac cacggtcacg cttcggtgcc tctccccgat tcgggcccgg 113580 tcgcttgcta ccggtgcgcc accaccagag gccatatccg acaccccagc cccgacggca 113640 gccgacagcc cggtcatggc gactgacatt gatatgctaa ttgacctcgg cctggacctc 113700 tccgacagcg atctggacga ggaccccccc gagccggcgg agagccgccg cgacgacctg 113760 gaatcggaca gcaacgggga gtgttcctcg tcggacgagg acatggaaga cccccacgga 113820 gaggacggac cggagccgat actcgacgcc gctcgcccgg cggtccgccc gtctcgtcca 113880 gaagaccccg gcgtacccag cacccagacg cctcgtccga cggagcggca gggccccaac 113940 gatcctcaac cagcgcccca cagtgtgtgg tcgcgcctcg gggcccggcg accgtcttgc 114000 tcccccgagc ggcacggggg caaggtggcc cgcctccaac ccccaccgac caaagcccag 114060 cctgcccgcg gcggacgccg tgggcgtcgc aggggtcggg gtcgcggtgg tcccggggcc 114 120 gccgatggtt tgtcggaccc ccgccggcgt gcccccagaa ccaatcgcaa cccgggggga 114180 ccccgccccg gggcggggtg gacggacggc cccggcgccc cccatggcga ggcgtggcgc 114 240 ggaagtgagc agcccgaccc acccggaggc ccgcggacac ggagcgtgcg ccaagcaccc 114 300 cccccgctaa tgacgctggc gattgccccc ccgcccgcgg acccccgcgc cccggccccg 114360 gagcgaaagg cgcccgccgc cgacaccatc gacgccacca cgcggttggt cctgcgctcc 114420 atctccgagc gcgcggcggt cgaccgcatc agcgagagct tcggccgcag cgcacaggtc 114480 atgcacgacc cctttggggg gcagccgttt cccgccgcga atagcccctg ggccccggtg 114540 ctggcgggcc aaggagggcc ctttgacgcc gagaccagac gggtctcctg ggaaaccttg 114600 gtcgcccacg gcccgagcct ctatcgcact tttgccggca atcctcgggc cgcatcgacc 114660 gccaaggcca tgcgcgactg cgtgctgcgc caagaaaatt tcatcgaggc gctggcctcc 114 720 gccgacgaga cgctggcgtg gtgcaagatg tgcatccacc acaacctgcc gctgcgcccc 114780 caggacccca ttatcgggac ggccgcggcg gtgctggata acctcgccac gcgcctgcgg 114840 ccctttctcc agtgctacct gaaggcgcga ggcctgtgcg gcctggacga actgtgttcg 114900 cggcggcgtc tggcggacat taaggacatt gcatccttcg tgtttgtcat tctggccagg 114960 ctcgccaacc gcgtcgagcg tggcgtcgcg gagatcgact acgcgaccct tggtgtcggg 115020 gtcggagaga agatgcattt ctacctcccc ggggcctgca tggcgggcct gatcgaaatc 115080 ctagacacgc accgccagga gtgttcgagt cgtgtctgcg agttgacggc cagtcacatc 115 140 gtcgcccccc cgtacgtgca cggcaaatat ttttattgca actccctgtt ttaggtacaa 115200 taaaaacaaa acatttcaaa caaatcgccc cacgtgttgt ccttctttgc tcatggccgg 115 260 cggggcgtgg gtcacggcag atggcggggg tgggcccggc gtacggcctg ggtgggcgga 115 320 gggaactaac ccaacgtata aatccgtccc cgctccaagg ccggtgtcat agtgccctta 115380 ggagcttccc gcccgggcgc atcccccctt ttgcactatg acagcgaccc ccctcaccaa 115440 cctgttctta cgggccccgg acataaccca cgtggccccc ccttactgcc tcaacgccac 115 500 ctggcaggcc gaaacggcca tgcacaccag caaaacggac tccgcttgcg tggccgtgcg 115560 gagttacctg gtccgcgcct cctgtgagac cagcggcaca atccactgct ttttctttgc 115620 ggtatacaag gacacccacc atacccctcc gctgattacc gagctccgca actttgcgga 115680 cctggttaac cacccgccgg tcctacgcga actggaggat aagcgcgggg tgcggctgcg 115740 gtgtgcgcgg ccgtttagcg tcgggacgat taaggacgtc tctgggtccg gcgcgtcctc 115800 ggcgggagag tacacgataa acgggatcgt gtaccactgc cactgtcggt atccgttctc 115860 aaaaacatgc tggatggggg cctccgcggc cctacagcac ctgcgctcca tcagctccag 115920 cggcatggcc gcccgcgcgg cagagcatcg acgcgtcaag attaaaatta aggcgtgatc 115980 tccaaccccc catgaatgtg tgtaaccccc cccaaaaaaa taaagagccg taacccaacc 116040 aaaccaggcg tggtgtgagt ttgtggaccc aaagccctca gagacaatgc gacaggccag 116 100 tatggaccgt gatactttta tttattaact cacaggggcg cttaccgcca caggaatacc 116 160 agaataatga ccaccacaat cgcgaccacc ccaaatacag catggcgcca caccacgcca 116 220 caacagccct gtcgccggta tggggcatga tcagacgagc cgcgcgccgc gcgttgggcc 116280 ctgtacagct cgcgcgaatt gaccctagga ggccgccacg cgcccgagtt ttgcgttcgt 116340 cgctggtcgt cgggcgccaa agccccggac ggctgttcgg tcgaacgaac ggccacgaca 116400 gtggcatagg ttggggggtg gtccgacata gcctcggcgt acgtcgggag gcccgacaag 116460 aggtcccttg tgatgtcggg tggggccaca agcctggttt ccggaagaaa caggggggtt 116520 gccaataacc cgccagggcc aaaactccgg cgctgcgcac gtcgttcggc gcggcgccgg 116580 gcgcgccgag cggctcgctg ggcggcttgg cgtgagcggc cccgctccga cgcctcgccc 116640 tctccggagg aggttggcgg aattggcacg gacgacaggg gcccagcaga gtacggtgga 116700 ggtgggtccg tgggggtgtc cagatcaata acgacaaacg gcccctcgtt cctaccagac 116760 aagctatcgt aggggggcgg gggatcagca aacgcgttcc ccgcgctcca tagacccgcg 116820 tcgggttgcg ccgcctccga agccatggat gcgccccaaa gccacgactc ccgcgcgcta 116880 ggtccttggg gtaagggaaa aggccctact ccccatccaa gccagccaag ttaacgggct 116940 acgccttcgg ggatgggact ggcaccccgg cggattttgt tgggctggta cgcgtcgccc 117000 aaccgagggc cgcgtccacg ggacgcgcct tttataaccc cggggtcatt cccaacgatc 117060 acatgcaatc taactggctc ccctctcccc ccctctcccc tctccccccc tctcccctct 117 120 ccccccctct cccctctccc cccctctccc ctctcccccc ctctcccctc tccccccctc 117 180 tcccctctcc ccccctctcc cctctccccc cctctcccct ctccccccct ctcccctctc 117 240 cccccctctc ccctgctctt tccccgtgac acccgacgct ggggggcgtg gctgccggga 117 300 ggggccgcgt atgggcgggc ctactcggtc tcccgccccc ccgaaccgcc ccgccggctt 117360 tgcccccctt tgatcccctg ctacccccac cccgtgctcg tggtgcgggg tggggggatg 117 420 tgggcggggg tgcgcgggag gtgtcggtgg tgggggtggt ggtggtggtg gtagtaggaa 117480 tggtggtggg ggggagggcg ctggttggtc aaaaaaggga gggacggggg ccggcagacc 117540 gacggcgaca acgctccccg gcggccgggt cgcggctctt acgagcggcc cggcccgcgc 117600 tcccaccccc cgggccgtgt ccttgctttc cccccgtctc cccccccgcc ttctcctcct 117660 cctcctcgtt tttccaaacc ccgcccaccc ggcccggccc ggcccggccc ggccaccgcc 117 720 gcccacccac ccacctcggg atacccagcc ccggtccccc gttccccggg ggccgttatc 117780 tccagcgccc cgtccggcgc gccgcccccc gccgctaaac cccatcccgc ccccgggacc 117840 ccacatataa gcccccagcc acacgcaaga acagacacgc agaacggctg tgtttatttt 117900 aaataaaccg atgtcggaat aaacaaacac aaacacccgc gacgggggga cggaggggac 117960 ggagggaggg gggtgacggg ggacggaaac agacacaaaa aacaaccaca aaaaacaacc 118020 acccaccgac acccccaccc cagtctcctc gccttctccc acccacccca cgcccccact 118080 gagcccggtc gatcgacgag cacccccgcc cacgcccccg cccctgcccc ggcgaccccc 118 140 ggcccgcacg atcccgacaa caataacaac cccaacggaa agcggcgggg tgttggggga 118200 ggcgaggaac aaccgagggg aacgggggat ggaaggacgg gaagtggaag tcctgatacc 118 260 catcctacac ccccctgcct tccaccctcc ggccccccgc gagtccaccc gccggccggc 118320 taccgagacc gaacacggcg gccaccgccg ccgccgccgc cgacaccgca gagccggcgc 118380 gcgcacacac aagcggcaga ggcagaaagg ccccgagtca ttgtttatgt ggccgcgggc 118440 cagcagacgg cccgcgacac ccccccccgc ccgtgtgggt atccggcccc ccgccccgcg 118500 ccggtccatt aagggcgcgc gtgcccgcga gatatcaatc cgttaagtgc tctgcagaca 118560 ggggcaccgc gcccggaaat ccattaggcc gcagacgagg aaaataaaat tacatcacct 118620 acccatgtgg tgctgtggcc tgtttttgct gcgtcatctg agcctttata aaagcggggg 118680 cgcggccgtg ccgatcgccg gtggtgcgaa agactttccg ggcgcgtccg ggtgccgcgg 118740 ctctccgggc ccccctgcag ccggggcggc caaggggcgt cggcgacatc ctccccctaa 118800 gcgccggccg gccgctggtc tgttttttcg ttttccccgt ttcgggggtg gtgggggttg 118860 cggtttctgt ttctttaacc cgtctggggt gtttttcgtt ccgtcgccgg aatgtttcgt 118920 tcgtctgtcc cctcacgggg cgaaggccgc gtacggcccg ggacgagggg cccccgaccg 118980 cggcggtccg ggccccgtcc ggacccgctc gccggcacgc gacgcgaaaa aggccccccg 119040 gaggcttttc cgggttcccg gcccggggcc tgagatgaac actcggggtt accgccaacg 119 100 gccggccccc gtggcggccc ggcccggggc cccggcggac ccaaggggcc ccggcccggg 119 160 gccccacaac ggcccggcgc atgcgctgtg gttttttttt cctcggtgtt ctgccgggct 119 220 ccgtcgcctt tcctgttctc gcttctcccc cccccccttc acccccagta ccctcctccc 119280 tcccttcctc ccccgttatc ccactcgtcg agggcgcccc ggtgtcgttc aacaaagacg 119340 ccgcgtttcc aggtaggtta gacacctgct tctccccaat agaggggggg ggacccaaac 119400 gacagggggc gccccagagg ctaaggtcgg ccacgccact cgcgggtggg ctcgtgttac 119460 agcacaccag cccgttattt tccccccctc ccacccttag ttagactctg ttacttaccc 119520 gtccgaccac caactgcccc cttatctaag ggccggctgg aagaccgcca gggggtcggc 119580 cggtgtcgct gtaacccccc acgccaatga cccacgtact ccaagaaggc atgtgtccca 119640 ccccgcctgt gtttttgtgc ctggctctct atgcttgggt cttactgcct gggggggggg 119700 agtgcggggg aggggggggg tgtggaagga aatgcacggc gcgtgtgtac ccccccctaa 119760 agttgttcct aaagcgagga tatggaggag tggcgggtgc cgggggaccg gggtgatctc 119820 tggcacgcgg gggtgggaag ggtcggggga gggggggatg gggtaccggc ccacctggcc 119880 ggcgcgggtg cgcgtgcctt tgcacaccaa ccccacgtcc cccggcggtc tctaagaaac 119940 accgcccccc ctccttcata ccaccgagca tgcctgggtg tgggttggta accaacacgc 120000 ccatcccctc gtctcctgtg attctctggc tgcaccgcat tcttgttttc taactatgtt 120060 cctgtttctg tctccccccc cacccctccg ccccaccccc caacacccac gtctgtggtg 120 120 tggccgaccc ccttttgggc gccccgtccc gccccgctac ccctcccatc ctttgttgcc 120 180 ctatagtgta gttaaccccc ccccccgccc tttgtggcgg ccagaggcca ggtcagtccg 120 240 ggcgggcagg cgctcgcgga aacttaacac ccacacccaa cccactgtgg ttctggctcc 120 300 atgccagtgg caggatgctt tcggggatcg gtggtcaggc agcccgggcc gcggctctgt 120 360 ggttaacacc agagcctgcc caacatggca cccccactcc cacgcacccc cactcccacg 120420 cacccccact cccacgcacc cccactccca cgcaccccca ctcccacgca cccccactcc 120480 cacgcacccc cactcccacg cacccccact cccacgcacc cccactccca cgcacccccg 120 540 cgatacatcc aacacagaca gggaaaagat acaaaagtaa acctttattt cccaacagac 120 600 agcaaaaatc ccctgagttt tttttattag ggccaacaca aaagacccgc tggtgtgtgg 120660 tgcccgtgtc tttcactttc cacctccccg acacggattg gctggtgtag tgggcgcggc 120 720 cagagaccac ccagcgcccg acccccccct ccccacaaac acgggggcgt cccttattgt 120780 tttccctcgt cccgggtcga cgccccctgc tccccggacc acgggtgccg agaccgcagg 120840 ctgcggaagt ccagggcgcc cactagggtg ccctggtcga acagcatgtt ccccacgggg 120900 gtcatccaga ggctgttcca ctccgacgcg ggggccgtcg ggtactcggg gggcgtcacg 120960 tggttacccg cggtctcggg gagcagggtg cggcggctcc agccggggac cgcggcccgc 121020 agccgggtcg ccatgtttcc cgtctggtcc accaggacca cgtacgcccc gatgttcccc 121080 gtctccatgt ccaggatggg caggcagtcc cccgtgatcg tcttgttcac gtaaggcgac 121 140 agggcgacca cgctagagac ccccgagatg ggcaggtagc gcgtgaggcc gcccgcgggg 121200 acggccccgg aagtctccgc gtggcgcgtc ttccgggcac acttcctcgg cccccgcggc 121260 ccagaagcag cgcgggggcc gagggaggtt tcctcttgtc tccctcccag ggcaccgacg 121320 gccccgcccg aggaggcgga agcggaggag gacgcggccc cggtggcgga agaggtggcc 121380 cccgcgggag tcggggccga ggaggaagag gcggaggagg aagaggcgga ggccgccgag 121440 gacgtcaggg gggtcccggg ccctccctgg ccgcgccccc ccggccctga gtcggagggg 121500 gggtgcgtcg ccgccctctt ggcccctgcc ggcgcgaggg ggggacgcgt ggactggggg 121560 gaggggtttt cctggcccga cccgcgcctc ttcctcggac gcaccgccgc ctcctgctcg 121620 acagaggcgg cggaggggag cgggggggcg ccggaggggg cggcgccgga gggggcggcg 121680 ccgcgggagg gcccgtgtcc accctccacg cccggccccc ccgagccgcg cgccaccgtc 121740 gcacgcgccc ggcacagact ctgttcttgg ttcgcggcct gagccaggga cgagtgcgac 121800 tggggcacac ggcgcgcgtc cgcggggcgg gcggccggct ccgccccggg ggccggggcg 121860 cgggggccgg gccccggagg cggcgcccgc acacacgggg ccacggccgc gcgggggcgc 121920 gcggggcccg acgcggccgc ggacgcgggg ggaccggggc ggggggcgga gcctggcatg 121980 ggcgccgcgg ggggcctgtg gggagaggcc gggggggagt cgctgatcac tatggggtct 122040 ctgttgtttg caaggggggc gggtctgttg acaagggggc ccgtccggcc cctcggccgc 122 100 cccgcctccg cttcaacaac cccaaccccc ccggaggggc cagacgcccc ccgcggcacc 122160 gcggctcgcg actggcggga gccgccgccg ccgctgctgt tggtggtggt gttagtgtta 122 220 ctgctgccgt gtggcccgat gggcgccgag gggggcgctg tccgagccgc ggccggctgg 122 280 ggggctgcgt gagacgcccc gcccgtcacg gggggcgcgg cggcgcctct gcgtgggggg 122 340 gcgcggggcg tccggcgggg ggcgggcggt acgtagtctg ctgcaagaga caacgggggg 122 400 cgcgatcagg ttacgccccc tccccggccc gccctttcct cgcccgcccg cccgcctatt 122 460 cctccctccc ccccccctcc tcctcctccc ccagggtcct cgccgccccc ccgcctcacc 122520 gtcgtccagg tcgtcgtcat cctcgtccgt ggtgggctca gggtgggtgg gcgacagggc 122580 cctcaccgtg tgccccccca gggtcaggta ccgcggggcg aaccgctgat tgcccgtcca 122 640 gataaagtcc acggccgtgc ccgccctgac ggcctcctcg gcctccatgc gggtctgggg 122 700 gtcgttcacg atcgggatgg tgctgaacga cccgctgggc gtcacgccca ctatcaggta 122760 caccagcttg gcgttgcaca gcgggcaggt gttgcgcaat tgcatccagg ttttcatgca 122820 cgggatgcag aagcggtgca tgcacgggaa ggtgtcgcag cgcaggtggg gcgcgatctc 122880 atccgtgcac acggcgcaca cgtcgccctc gtcgctcccc ccgtcctctc gagggggggc 122940 gcccccgcaa ctgccggggt cttcctcgcg gggggggctc ccccccgaga ccgccccccc 123000 atccacgccc tgcggcccca gcagccccgt ctcgaacagt tccgtgtccg tgctgtccgc 123060 ctcggaggcg gagtcgtcgt catggtggtc ggcgtccccc cgccccccca cttcggtctc 123 120 cgcctccgag tcgctgctgt ccggcaggtc tcggtcgcag ggaaacaccc agacatccgg 123180 ggcgggctga ggggaaaaaa gggggggcgg gtaagaatgg ggggatttcc cgcgtcaatc 123 240 agcgcccacg agttccccct ccccccccgc ctcacaaagt cctgcccccc tgctggcctc 123 300 ggaagagggg ggagaaaggg gtctgcaacc aaaggtggtc tgggtccgtc ctttggatcc 123360 cgacccctct tcttccctct tctcccgccc tccagacgca ccggagtcgg gggtcccacg 123420 gcgtccccca aatatggcgg gcggctcctc cccacccccc tagatgcgtg tgagtaaggg 123480 ggccctgcgt atgagtcagt ggggaccacg ccccctaaca cggcgacccc ggtccctgtg 123540 tgtttgttgt gggggcgtgt ctctgtgtat gagtcagggg ggtcccacgg cgaccccggg 123600 ccctgcgtct gagtcaaagg ggccatgtgt aggtgttggg ggtctgtata tataaagtca 123660 gggggtcaca tggcgacccc taacagggcg accccggtcc ctgtatatat agggtcaggg 123 720 ggttccgcgc cccctaacat ggcgcccccg gtccctgtat atatagtgtc acggggttcc 123780 acgcccccta acatggcgcc ccaacatggc gcccggctcc cgtgtatgag tgggggtccc 123840 ccaacatggc ggccggttcc agtgtaaggg tcgggggtcc cccaacatgg cgccccccaa 123900 catggcgccc cccaacatgg cgccccagac atggcgcccg gcccctcacc tcgcgctggg 123960 ggcggccctc aggccggcgg gtactcgctc cggggcgggg ctccatgggg gtcgtatgcg 124020 gctggagggt cgctgacgga gggtccctgg gggtcgcaac gtaggcgggg cttctgtggt 124080 gatgcggaga gggggcggcc cgagtctgcc tggctgctgc gtctcgctcc gagtgccgag 124 140 gtgcaaatgc gaccagaccg tcgggccagg gctaacttat accccacgcc tttcccctcc 124200 ccaaaggggc ggcagtgacg attcccccaa tggccgcgcg tcccagggga ggcaggccca 124 260 ccgcggggcg gccccgtccc cggggaccaa cccggcgccc ccaaagaata tcattagcat 124320 gcacggcccg gcccccgatt tgggggacca acccggtgtc ccccaaagaa ccccattagc 124380 atgcccctcc cgccgacgca acaggggctt ggcctgcgtc ggtgccccgg ggcttcccgc 124440 cttcccgaag aaactcatta ccatacccgg aaccccaggg gaccaatgcg ggttcattga 124500 gcgacccgcg ggccaatgcg cgaggggccg tgtgttccgc caaaaaagca attaacataa 124560 cccggaaccc caggggagtg gttacgcgcg gcgcgggagg cggggaatac cggggttgcc 124620 cattaagggc cgcgggaatt gccggaagcg ggaagggcgg ccggggccgc ccattaatga 124680 gtttctaatt accataccgg gaagcggaac aaggcctctg caagttttta attaccatac 124740 cgggaagtgg gcggcccggc ccactgggcg ggagttaccg cccagtgggc cgggccccga 124800 cgactcggcg gacgctggtt ggccgggccc cgccgcgctg gcggccgccg attggccagt 124860 cccgccctcc gagggcgggc ccgcctcggg ggcgggccgg ctccaagcgt atatatgcgc 124920 ggctcctgcc atcgtctctc cggagagcgg cttggtgcgg agctcccggg agctccgcgg 124980 aagacccagg ccgcctcggg tgtaacgtta gaccgagttc gccgggccgg ctccgcgggc 125040 cagggcccgg gcacgggcct cgggccccag gcacggcccg atgaccgcct cggcctccgc 125 100 cacccggcgc cggaaccgag cccggtcggc ccgctcgcgg gcccacgagc cgcggcgcgc 125 160 caggcgggcg gccgaggccc agaccaccag gtggcgcacc cggacgtggg gcgagaagcg 125 220 cacccgcgtg ggggtcgcgg gggtcgcggg ggtcgcgggg ggcttcggcg ccccctcccc 125280 gcccgcgcgt cgcaggcgca ggcgcgccag gtgctctgcg gtgacgcgca ggcggagggc 125 340 gaggcgcggc ggaaggcgga aggggcgtga gggggggtgg gaggggttag ccccgccccc 125 400 cgggcccgcg ccgggcggtg gggaccgggg gcggggggcg gcggcggtgg gccgggcctc 125460 tggcgccggc tcgggcgggg ggctgtccgg ccagtcgtcg tcgtcgtcgt cggacgcgga 125520 ctcgggaacg tggagccact ggcgcagcag cagcgaacaa gaaggcgggg gcccactggc 125580 ggggggcggc ggcggggcgg ccgcgggcgc gctcctgacc acgggttccg agttgggcgt 125 640 ggaggttacc tgggactgtg cggttgggac cgcgcccgtg ggcccgggcg gccgggggcg 125 700 gcgggggccg cgatggcggc ggcgggccat ggagacagag agcgtgccgg ggtggtagag 125760 tttgacaggc aagcatgtgc gtgcagaggc gagtagtgct tgcctgtcta actcgctagt 125820 ctcggccgcg gggggcccgg gctgcccgcc gcccgccttt aaagggccgc gcgcgacccc 125880 cggggggtgt gttttggggg gggcccgttt ccggggtctg gccgctcctc ccccgctcct 125940 ccccccgctc ctccccccgc tcctcccccc gctcctcccc ccgctcctcc ccccgctcct 126000 ccccccgctc ctccccccgc tcctcccccc gctcctcccc ccgctcctcc ccccgctcct 126060 ccccccgctc ctccccccgc tcctcccccc gctcctcccc ccgctcctcc ccccgctcct 126 120 cccccgctcc tcccccgctc ccgcggcccc gccccccacg cccgccgcgc gcgcgcacgc 126 180 cgcccggacc gccgcccgcc ttttttgcgc gcgcgcgcgc ccgcgggggg cccgggctgc 126 240 cacaggtaaa acaacaccaa caaagcacgg cgcaatccgc acgtcacacg tcacgtcatc 126 300 caccacacct gcccaacaac acaactcaca gcgacaactc accgcgcaac aactcctgtt 126360 cctcatccac acgtcaccgc gcacctcccg ctcctccaga cgtaccccgg cgcaacacac 126420 cgctcctgct acacaccacc gcccctcccc agccccagcc ctccccagcc ccagccctcc 126480 ccggccccag ccctccccgg ccccagccct ccccggcccc agccctcccc ggccccagcc 126540 ctccccggcc ccagccctcc ccagccccag ccctccccag ccgcgtcccg cgctccctcg 126600 ggggggttcg ggcatctcta cctcagtgcc gccaatctca ggtcagagat ccaaaccctc 126660 cgggggcgcc cgcgcaccac caccgcccct cgccccctcc cgcccctcgc cccctcccgc 126720 ccctcgcccc ctcccgcccc tcgccccctc ccgcccctcg ccccctcccg cccctcgccc 126780 cctcccgccc ctcgccccct cccgcccctc gccccctccc gcccctcgcc ccctcccgcc 126840 cctcgccccc tcccgcccct cgccccctcc cgcccctcgc cccctcccgc ccctcgcccc 126900 ctcccgcccc tcgccccctc ccgcccctcg ccccctcccg cccctcgccc cctcccgccc 126960 ctcgccccct cccgcccctc gccccctccc gcccctcgcc ccctcccgcc cctcgaataa 127020 acaacgctac tgcaaaactt aatcaggtcg ttgccgttta ttgcgtcttc gggtttcaca 127080 agcgccccgc cccgtcccgg cccgttacag caccccgtcc ccctcgaacg cgccgccgtc 127 140 gtcttcgtcc caggcgcctt cccagtccac aacgtcccgt cgcgggggcg tggccaagcc 127200 cgcctccgcc cccagcacct ccacggcccc cgccgccgcc agcacggtgc cgctgcggcc 127 260 cgtggccgag gcccagcgaa tcccgggcgg cgccggcggc agggcccccg ggccgtcgtc 127320 gtcgtcgccg cgcagcacca gcgggggggc gtcgtcgtcg ggctccagca gggcgcgggc 127380 gcaaaagtcc ctccgcggcc cgcgccaccg ggccgggccg gcgcgcaccg cctcgcgccc 127440 cagcgccacg tacacgggcc gcagcggcgc gcccaggccc cagcgcgcgc aggcgcggtg 127500 cgagtgggcc tcctcctcgc agaagtccgg cgcgccgggc gccatggcgt cggtggtccc 127560 cgaggccgcc gcccggccgt ccagcgccgg cagcacggcc cggcggtact cgcgcgggga 127620 catgggcacc ggcgtgtccg ggccgaagcg cgtgcgcacg cggtagcgca cgttgccgcc 127680 gcggcacagg cgcagcggcg gcgcgtcggg gtacaggcgc gcgtgcgcgg cctccacgcg 127740 cgcgaagacc cccgggccga acacgcggcc cgaggccagc accgtgcggc gcaggtcccg 127800 cgccgccggc cagcgcacgg cgcactgcac ggcgggcagc aggtcgcacg ccaggtaggc 127860 gtgctgccgc gacaccgcgg gcccgtcggc gggccagtcg caggcgcgca cggtgttgac 127920 cacgatgagc cgccggtcgc cggcgctggc gagcagcccc agaaactcca cggccccggc 127980 gaaggccagg tcccgcgtgg acagcagcag cacgccctgc gcgcccagcg ccgacacgtc 128040 gggggcgccg gtccagttgc ccgcccaggc ggccgtgtcc ggcccgcaca gccggttggc 128 100 cagggccgcc agcaggcagg acagcccgcc gcgctcggcg gaccactccg gcggcccccc 128 160 cgaggccccg ccgccggcca ggtcctcgcc cggcagcggc gagtacagca ccaccacgcg 128 220 cacgtcctcg gggtcgggga tctggcgcat ccaggccgcc atgcggcgca gcgggcccga 128280 ggcgcgcagg gggccaaaga ggcggccccc ggcggccccg tgggggtggg ggttctcgtc 128340 gtcgtcgccg ccgcacgcgg cctgggcggc gggggcgggc ccggcgcacc gcgcggcgat 128 400 cgaggccagg gcccgcgggt caaacatgag ggccggtcgc caggggacgg ggaacagcgg 128460 gtggtccgtg agctcggcca cggcgcgcgg ggagcagtag gcctccaggg cggcggccgc 128520 gggcgccgcc gtgtggctgg gcccccgggg ctgccgccgc cagccgccca gggggtcggg 128580 gccctcggcg ggccggcgcg acagcgccac ggggcgcggg cgggcctgcg ccgcggcgcc 128640 ccgggccgcc gcgggctggg cgggggtggg ctcgggcccc gggggcgtgg aggggggcgc 128700 ggggaggggg gcgcgggcgt ccgagccggg ggcgtccgcg ccgctcttct tcgtcttcgg 128760 gggtcgcggg ccgccgcctc cgggcggccg ggccgggccg ggactcttgc gcttgcgccc 128820 ctcccgcggc gcggcggagg cggcggcggc cgccagcgcg tcggcggcgt ccggtgcgct 128880 ggccgccgcc gccagcaggg ggcggaggct ctggttctca aacagcaggt ccgcggcggc 128940 ggcggccgcg gagctcggca ggcgcgggtc ccgcggcagc gcggggccca gggccccggc 129000 gaccaggctc acggcgcgca cggcggccac ggcggcctcg ctgccgccgg ccacgcgcag 129060 gtccccgcgc aggcgcatga gcaccagcgc gtcgcgcacg aaccgcagct cgcgcagcca 129 120 cgcgcgcagg cggggcgcgt cggcgtgcgg cggcggcggg gaagcggggc ccgcgggtcc 129180 ctccggccgc ggggggctgg cgggccgggc cccggccagc cccgggacgg ccgccaggtc 129240 gccgtcgaag ccctcggcca gcgcctccag gatcccgcgg caggcggcca ggcactcgac 129 300 ggccacgcgg ccggcctggg cgcggcgccc ggcgtcggcg tcggcgtggc gggcggcgtc 129360 ggggtcgtcg ccccccacgg gggaggcggg cgcggcggac agccgcccca gggcggcgag 129420 gatccccgcg gcgccgtacc cggcgggcac cgcgcgctcg cccggtgcgg cggcggcgac 129480 ggcggcgacc ccctcgtcat ctgcgccggc gccggggctc cccgcggccc ccgtcagcgc 129540 cgcgttctcg cgcgccaaca ggggcgcgta ggcgcggcgc aggctggtca gcaggaagcc 129600 cttctgcgcg cggtcgtatc ggcggctcat ggccacggcg gccgccgcgt gcgccaggcc 129660 ccagccgaag cggccggccg ccatggcgta gcccaggtgg ggcacggccc gcgccacgct 129720 gccggtgatg aaggagctgc tgttgcgcgc ggcgcccgag atccggaagc aggcctggtc 129780 cagcgccacg tccccgggga ccacgcgcgg gttctggagc caccccatgg cctccgcgtc 129840 cggggtgtac agcagccgcg tgatcagggc gtactgctgc gcggcgtcgc ccagctcggg 129900 cgcccacacg gccgccgggg cgcccgaggc ctcgaaccgg cgtcgcgcct cctccgcctc 129960 gggcgccccc cagaggcccg ggcggctgtc gcccaggccg ccgtacagca cccgccccgg 130020 gggcgggggc ccggcgccgg gccacggctc cccgctgacg tacccgtcgc gatagcgcgc 130080 gtagaaggcg ccggaggccg cgtcggcgtc cagctcgacc cgccggggct gcccggccgt 130 140 gaagcggccc gtggcgtcgc ggccggccac cgccgcgcgg gcccggcggc gctcgatgcg 130 200 gcccgcggag gccgcggggg tcctcgccgc cgcccggggc ttgggcgcgg cctcggagag 130 260 ggggggtggc ccgggcgggg gcggcgtccg cccgggggct tccggcgccg cgctcgacgg 130 320 accccgcccg acggcccgcg cctcgcgtgc gtggtcggcc gcgtcgttgc cgtcgtcgtc 130 380 ctcgtcctcg tcggacgacg aggacgaaga ggatgcggac gacgaggacg aggacccgga 130440 gtccgacgag gtcgatgacg ccgatggccg ccgccggccg tgacgacgtc tccgcggcgg 130 500 ctgggccggc gggcgcggcg acaggcggtc cgtggggtcc ggatacgcgc cgcgtagcgg 130560 ggcctcccgt tcgcggcccc gggccggggc ccggtcgccg gcggcgtcgg ctgcgtcgtc 130620 gtactcgtcc ccgtcatcgt cgtcggctag aaaggcgggg gtccggggcg gcgaggccgc 130680 ggggtcgggc gtcgggatcg tccggacggc ctcctctacc atggaggcca gcagagccag 130740 ctgtcgcgac gagacggcgt ccccggcgtc ctcgccggcg tcggtgcccg ccgcgggggc 130 800 cctcccgtcc cgccgggcgt cgtcgaggtc gtgggggtgg tcggggtcgt ggtcggggtc 130860 gtccccgccc tcctccgtct ccgcgcccca cccgagggcc ccccgctcgt cgcggtctgg 130920 gctcggggtg ggcggcggcc cgtcggtggg gcccggggag ccggggcgct gcttgttctc 130980 cgacgccatc gccgatgcgg ggcgatcctc cggggatacg gctgcgacgg cggacgtagc 131040 acggtaggtc acctacggac tctcgatggg gggagggggc gagacccacg gaccccgacg 131 100 acccccgccg tcgacgcgga actagcgcgg accggtcgat gcttgggtgg ggaaaaagga 131 160 cagggacggc cgatccccct cccgcgcttc gtccgcgtat cggcgtcccg gcgcggcgag 131 220 cgtctgacgg tctgtctctg gcggtcccgc gtcgggtcgt ggatccgtgt cggcagccgc 131280 gctccgtgtg gacgatcggg gcgtcctcgg gctcatatag tcccaggggc cggcgggaag 131340 gaggagcagc ggaggccgcc ggccccccgc cccccggcgg gcccaccccg aacggaattc 131 400 cattatgcac gaccccgccc cgacgccggc acgccggggg cccgtggccg cggcccgttg 131460 gtcgaacccc cggccccgcc catccgcgcc atctgccatg gacggggcgc gagggcgggt 131520 gggtccgcgc cccgccccgc atggcatctc attaccgccc gatccggcgg tttccgcttc 131580 cgttccgcat gctaacgagg aacgggcagg gggcggggcc cgggccccga cttcccggtt 131640 cggcggtaat gagatacgag ccccgcgcgc ccgttggccg tccccgggcc cccggtcccg 131700 cccgccggac gccgggacca acgggacggc gggcggccct tgggccgccc gccttgccgc 131760 ccccccattg gccggcgggc gggaccgccc caagggggcg gggccgccgg gtaaaagaag 131820 tgagaacgcg aagcgttcgc acttcgtccc aatatatata tattattagg gcgaagtgcg 131880 agcactggcg ccgtgcccga ctccgcgccg gccccggggg cggacccggg cggcgggggg 131940 cgggtctctc cggcgcacat aaaggcccgg cgcgaccgac gcccgcagac ggcgccagcc 132000 acgaacgacg ggagcggctg cggagcacgc ggaccgggag cgggagtcgc agagggccgt 132060 cggagcggac ggcgtcggca tcgcgacgcc ccggctcggg atcgggatcg catcggaaag 132 120 ggacacgcgg acgcgggggg gaaagacccg cccaccccac ccacgaaaca caggggacgc 132 180 accccggggg cctccgacga cagaaaccca ccggtccgcc ttttttgcac gggtaagcac 132 240 cttgggtggg cagaggaggg gggacgcggg ggcggaggag gggggacgcg ggggcggagg 132 300 aggggggacg cgggggcgga ggagggggga cgcgggggcg gaggaggggg gacgcggggg 132 360 cggaggaggg ggctcacccg cgttcgtgcc ttcccgcagg aggaacgccc tcgtcgaggc 132420 gaccggcggc gaccgttgcg tggaccgctt cctgctcgtc gggggggggg gagccactgt 132 480 ggtcctccgg gacgttttct ggatggccga catttcccca ggcgcttttg tgccttgtgt 132540 aaaagcgcgg cgtcccgctc tccgatcccc gcccctgggc acgcgcaagc gcaagcgccc 132600 tgcccgcccc ctctcatcgg agtctgaggt cgaatccgag acagccttgg agtctgaggt 132660 cgaatccgag acagcatcgg attcgaccga gtctggggac caggaggaag ccccccgcat 132720 cggtggccgt agggcccccc ggaggcttgg ggggcggttt tttctggaca tgtcggcgga 132780 atccaccacg gggacggaaa cggatgcgtc ggtgtcggac gaccccgacg acacgtccga 132840 ctggtcttgt gacgacattc ccccacgacc caagcgggcc cgggtaaacc tgcggctcac 132900 tagctctccc gatcggcggg atggggttat ttttcctaag atggggcggg tccggtctac 132960 ccgggaaacg cagccccggg cccccacccc gtcggcccca agcccaaatg caatgctccg 133020 gcgctcggtg cgccaggccc agaggcggag cagcgcacga tggacccccg acctgggcta 133080 catgcgccag tgtatcaatc agctgtttcg ggtcctgcgg gtcgcccggg acccccacgg 133 140 cagtgccaac cgcctgcgcc acctgatacg cgactgttac ctgatgggat actgccgagc 133 200 ccgtctggcc ccgcgcacgt ggtgccgctt gctgcaggtg tccggcggaa cctggggcat 133 260 gcacctgcgc aacaccatac gggaggtgga ggctcgattc gacgccaccg cagaacccgt 133 320 gtgcaagctt ccttgtttgg aggccagacg gtacggcccg gagtgtgatc ttagtaatct 133380 cgagattcat ctcagcgcga caagcgatga tgaaatctcc gatgccaccg atctggaggc 133440 cgccggttcg gaccacacgc tcgcgtccca gtccgacacg gaggatgccc cctcccccgt 133500 tacgctggaa accccagaac cccgcgggtc cctcgctgtg cgtctggagg atgagtttgg 133560 ggagtttgac tggacccccc aggagggctc ccagccctgg ctgtctgcgg tcgtggccga 133620 taccagctcc gtggaacgcc cgggcccatc cgattctggg gcgggtcgcg cagcagaaga 133680 ccgcaagtgt ctggacggct gccggaaaat gcgcttctcc accgcctgcc cctatccgtg 133740 cagcgacacg tttctccggc cgtgagtccg gtcgccccga cccccttgta tgtccccaaa 133800 ataaaagacc aaaatcaaag cgtttgtccc agcgtcttaa tggcgggaag ggcggagaga 133860 aacagaccac gcgtacatgg ggggtgtttg ggggtttatt gacatcgggg ctacagggtg 133920 gtaaccggat agcagatgtg aggaagtctg ggccgttcgc cgcgaacggc gatcagaggg 133980 tccgtttctt gcggaccacg gcccggtgat gtgggttgct cgtctaaaat ctcgggcata 134040 cccatacacg cacaacacgg acgccgcacc gaatgggacg tcgtaagggg gtgggaggta 134 100 gctgggtggg gtttgtgcag agcaatcagg gaccgcagcc agcgcataca atcgcgctcc 134 160 cgtccgttgg tcccgggcag gaccacgccg tactggtatt cgtaccggct gagcagggtc 134 220 tccagggggt ggttgggtgc cgcggggaac ggggtccacg ccacggtcca ctcgggcaaa 134280 aaccgagtcg gcacggccca cggttctccc acccacgcgt ctggggtctt gatggcgata 134340 aatcttaccc cgagccggat tttttgggcg tattcgagaa acggcacaca cagatccgcc 134 400 gcgcctacca cccacaagtg gtagaggcga ggggggctgg gttggtctcg gtgcaacagt 134460 cggaagcacg ccacggcgtc cacgacctcg gtgctctcca aggggctgtc ctccgcaaac 134520 aggcccgtgg tggtgtttgg ggggcagcga caggacctag tgcgcacgat cgggcgggtg 134580 ggtttgggta agtccatcag cggctcggcc aaccgtcgaa ggttggccgg gcgaacgacg 134640 accggggtac ccaggggttc tgatgccaaa atgcggcact gcctaagcag gaagctccac 134700 agggccgggc ttgcgtcgac ggaagtccgg ggcagggcgt tgttctggtc aaggagggtc 134760 attacgttga cgacaacaac gcccatgttg gtatattaca ggcccgtgtc cggtttgggg 134820 cacttgcaga tttgtaaggc cacgcacggc ggggagacag gccgacgcgg gggctgctct 134880 aaaaatttaa gggccctacg gtccacagac ccgccttccc gggggggccc ttggagcgac 134940 cggcagcgga ggcgtccggg ggaggggagg gttatttacg ggggggtagg tcagggggtg 135000 ggtcgtcaaa ctgccgctcc ttaaaacccc ggggcccgtc gttcggggtg ctcgttggtt 135060 ggcactcacg gtgcggcgaa tggcctgtcg taagttttgt cgcgtttacg ggggacaggg 135 120 caggaggaag gaggaggccg tcccgccgga gacaaagccg tcccgggtgt ttcctcatgg 135 180 ccccttttat accccagccg aggacgcgtg cctggactcc ccgcccccgg agacccccaa 135 240 accttcccac accacaccac ccggcgatgc cgagcgcctg tgtcatctgc aggagatcct 135 300 ggcccagatg tacggaaacc aggactaccc catagaggac gaccccagcg cggatgccgc 135 360 ggacgatgtc gacgaggacg ccccggacga cgtggcctat ccggaggaat acgcagagga 135420 gctttttctg cccggggacg cgaccggtcc ccttatcggg gccaacgacc acatccctcc 135480 cccgcgtggc gcatctcccc ccggtatacg acgacgcagc cgggatgaga ttggggccac 135 540 gggatttacc gcagaagagc tggacgccat ggacaggcag gcggctcgag ccatcagccg 135 600 cggcggcaag cccccctcga ccatggccaa gctggtgact ggcatgggct ttacgatcca 135660 cggagcgctc accccaggat cggaggggtg tgtctttgac agcagccacc cagattaccc 135 720 ccaacgggta atcgtgaagg cggggtggta cacgagcacg agccacgagg cgcgactgct 135780 gaggcgactg gaccacccgg cgatcctgcc cctcctggac ctgcatgtcg tctccggggt 135840 cacgtgtctg gtcctcccca agtaccaggc cgacctgtat acctatctga gtaggcgcct 135900 gaacccactg ggacgcccgc agatcgcagc ggtctcccgg cagctcctaa gcgccgttga 135960 ctacattcac cgccagggca ttatccaccg cgacattaag accgaaaata tttttattaa 136020 cacccccgag gacatttgcc tgggggactt tggtgccgcg tgcttcgtgc agggttcccg 136080 atcaagcccc ttcccctacg gaatcgccgg aaccatcgac accaacgccc ccgaggtcct 136140 ggccggggat ccgtatacca cgaccgtcga catttggagc gccggtctgg tgatcttcga 136200 gactgccgtc cacaacgcgt ccttgttctc ggccccccgc ggccccaaaa ggggcccgtg 136260 cgacagtcag atcacccgca tcatccgaca ggcccaggtc cacgttgacg agttttcccc 136320 gcatccagaa tcgcgcctca cctcgcgcta ccgctcccgc gcggccggga acaatcgccc 136380 gccttacacc cgaccggcct ggacccgcta ctacaagatg gacatagacg tcgaatatct 136440 ggtttgcaaa gccctcacct tcgacggcgc gcttcgcccc agcgccgcag agctgctttg 136500 tttgccgctg tttcaacaga aatgaccgcc cccggggggc ggtgctgttt gcgggttggc 136560 acaaaaagac cccgacccgc gtctgtggtg tttttggcat catgtcgccg ggcgccatgc 136620 gtgccgttgt tcccattatc ccattccttt tggttcttgt cggtgtatcg ggggttccca 136680 ccaacgtctc ctccaccacc caaccccaac tccagaccac cggtcgtccc tcgcatgaag 136740 cccccaacat gacccagacc ggcaccaccg actctcccac cgccatcagc cttaccacgc 136800 ccgaccacac accccccatg ccaagtatcg gactggagga ggaggaggaa gaggaggagg 136860 gggccgggga tggcgaacat cttaaggggg gagatgggac ccgtgacacc ctaccccagt 136920 ccccgggtcc agccgtcccg ttggccgggg atgacgagaa ggacaaaccc aaccgtcccg 136980 tagtcccacc ccccggtccc aacaactccc ccgcgcgccc cgagaccagt cgaccgaaga 137040 caccccccac cagtatcggg ccgctggcaa ctcgacccac gacccaactc ccctcaaagg 137 100 ggcgaccctt ggttccgacg cctcaacata ccccgctgtt ctcgttcctc actgcctccc 137 160 ccgccctgga caccctcttc gtcgtcagca ccgtcatcca caccttatcg tttgtgtgta 137 220 ttgttgctat ggcgacacac ctgtgtggtg gttggtccag acgcgggcga cgcacacacc 137280 ctagcgtgcg ttacgtgtgc ctgccgcccg aacgcgggta gggtatgggg cggggatggg 137340 gagagcccac acgcggaaag caagaacaat aaaggcggcg ggatctagtt gatatgcgtc 137 400 tctgggtgtt tttggggtgt ggtgggcgcg gggcggtcat tggacggggg tgcagttaaa 137460 tacatgcccg ggacccatga agcatgcgcg acttccgggc ctcggaaccc acccgaaacg 137520 gccaacggac gtctgagcca ggcctggcta tccggagaaa cagcacacga cttggcgttc 137580 tgtgtgtcgc gatgtctctg cgcgcagtct ggcatctggg gcttttggga agcctcgtgg 137640 gggctgttct tgccgccacc catctgggac ctgcggccaa cacaacggac cccttaacgc 137700 acgccccagt gtcccctcac cccagccccc tggggggctt tgccgtcccc ctcgtagtcg 137760 gtgggctgtg tgccgtagtc ctgggggcgg cgtgtctgct tgagctcctg cgtcgtacgt 137820 gccgcgggtg ggggcgttac catccctaca tggacccagt tgtcgtataa ttttttcccc 137880 cccccccttc tccgcatggg tgatgtcggg tccaaactcc cgacaccacc agctggcatg 137940 gtataaatca ccggtgcgcc ccccaaacca tgtccggcag ggggatgggg ggcgaatgcg 138000 gagggcaccc aacaacaccg ggctaaccag gaaatccgtg gccccggccc ccaacaaaga 138060 tcgcggtagc ccggccgtgt gacattatcg tccataccga ccacaccgac gaatccccta 138 120 agggggaggg gccattttac gaggaggagg ggtataacaa agtctgtctt taaaaagcag 138 180 gggttaggga gttgttcggt cataagcttc agtgcgaacg accaactacc ccgatcatca 138 240 gttatcctta aggtctcttt tgtgtggtgc gttccggtat ggggggggct gccgccaggt 138300 tgggggccgt gattttgttt gtcgtcatag tgggcctcca tggggtccgc ggcaaatatg 138360 ccttggcgga tgcctctctc aagatggccg accccaatcg ctttcgcggc aaagaccttc 138420 cggtcctgga ccagctgacc gaccctccgg gggtccggcg cgtgtaccac atccaggcgg 138480 gcctaccgga cccgttccag ccccccagcc tcccgatcac ggtttactac gccgtgttgg 138540 agcgcgcctg ccgcagcgtg ctcctaaacg caccgtcgga ggccccccag attgtccgcg 138600 gggcctccga agacgtccgg aaacaaccct acaacctgac catcgcttgg tttcggatgg 138660 gaggcaactg tgctatcccc atcacggtca tggagtacac cgaatgctcc tacaacaagt 138720 ctctgggggc ctgtcccatc cgaacgcagc cccgctggaa ctactatgac agcttcagcg 138780 ccgtcagcga ggataacctg gggttcctga tgcacgcccc cgcgtttgag accgccggca 138840 cgtacctgcg gctcgtgaag ataaacgact ggacggagat tacacagttt atcctggagc 138900 accgagccaa gggctcctgt aagtacgccc tcccgctgcg catccccccg tcagcctgcc 138960 tctcccccca ggcctaccag cagggggtga cggtggacag catcgggatg ctgccccgct 139020 tcatccccga gaaccagcgc accgtcgccg tatacagctt gaagatcgcc gggtggcacg 139080 ggcccaaggc cccatacacg agcaccctgc tgcccccgga gctgtccgag acccccaacg 139 140 ccacgcagcc agaactcgcc ccggaagacc ccgaggattc ggccctcttg gaggaccccg 139200 tggggacggt ggcgccgcaa atcccaccaa actggcacat cccgtcgatc caggacgccg 139 260 cgacgcctta ccatcccccg gccaccccga acaacatggg cctgatcgcc ggcgcggtgg 139320 gcggcagtct cctggcagcc ctggtcattt gcggaattgt gtactggatg caccgccgca 139380 ctcggaaagc cccaaagcgc atacgcctcc cccacatccg ggaagacgac cagccgtcct 139440 cgcaccagcc cttgttttac tagatacccc cccttaatgg gtgcgggggg gtcaggtctg 139500 cggggttggg atgggacctt aactccatat aaagcgagtc tggaaggggg gaaaggcgga 139560 cagtcgataa gtcggtagcg ggggacgcgc acctgttccg cctgtcgcac ccacagcttt 139620 ttcgcgaacc gtcccgtttc gggatgccgt gccgcccgtt gcagggcctg gtgctcgtgg 139680 gcctctgggt ctgtgccacc agcctggttg tccgtggccc cacggtcagt ctggtatcaa 139740 actcatttgt ggacgccggg gccttggggc ccgacggcgt agtggaggaa gacctgctta 139800 ttctcgggga gcttcgcttt gtgggggacc aggtccccca caccacctac tacgatgggg 139860 tcgtagagct gtggcactac cccatgggac acaaatgccc acgggtcgtg catgtcgtca 139920 cggtgaccgc gtgcccacgt cgccccgccg tggcatttgc cctgtgtcgc gcgaccgaca 139980 gcactcacag ccccgcatat cccaccctgg agctgaatct ggcccaacag ccgcttttgc 140040 gggtccggag ggcgacgcgt gactatgccg gggtgtacgt gttacgcgta tgggtcgggg 140 100 acgcaccaaa cgccagcctg tttgtcctgg ggatggccat agccgccgaa ggtactctgg 140 160 cgtacaacgg ctcggcccat ggctcctgcg acccgaaact gcttccgtct tcggccccgc 140 220 gtctggcccc ggcgagcgta taccaacccg cccctaaccc ggcctccacc ccctcgacca 140280 ccacctccac cccctcgacc accatccccg ctccccaagc atcgaccaca cccttcccca 140340 cgggagaccc aaaaccccaa cctcacgggg tcaaccacga acccccatcg aatgccacgc 140 400 gagcgacccg cgactcgcga tatgcgctaa cggtgaccca gataatccag atagccatcc 140460 ccgcgtccat tatagccctg gtgtttctgg ggagctgtat ttgctttata cacagatgtc 140520 aacgccgcta ccgacgctcc cgccgcccga tttacagccc ccagataccc acgggcatct 140580 catgcgcggt gaacgaagcg gccatggccc gcctcggagc cgagctcaaa tcgcatccga 140640 gcaccccccc caaatcccgg cgccggtcgt cacgcacgcc aatgccctcc ctgacggcca 140700 tcgccgaaga gtcggagccc gcgggggcgg ctgggcttcc gacgcccccc gtggacccca 140760 cgacatccac cccaacgcct cccctgttgg tataggtcca cggccactgg ccgggggcac 140820 cacataaccg accgcagtca ctgagttggg aataaaccgg tattatttac ctatatccgt 140880 gtatgtccat ttctttcttc cccccccccc ccggaaacca aagaaggaag caaagaatgg 140940 atgggaggag ttcaggaagc cggggagagg gcccgcggcg catttaaggc gttgttgtgt 141000 tgactttggc tcttctggcg ggttggtgcg gtgctgtttg ttgggctccc attttacccg 141060 aagatcggct gctatccccg ggacatggat cgcggggcgg tggtggggtt tcttctcggt 141120 gtttgtgttg tatcgtgctt ggcgggaacg cccaaaacgt cctggagacg ggtgagtgtc 141180 ggcgaggacg tttcgttgct tccagctccg gggcctacgg ggcgcggccc gacccagaaa 141240 ctactatggg ccgtggaacc cctggatggg tgcggcccct tacacccgtc gtgggtctcg 141300 ctgatgcccc ccaagcaggt gcccgagacg gtcgtggatg cggcgtgcat gcgcgctccg 141360 gtcccgctgg cgatggcgta cgcccccccg gccccatctg cgaccggggg tctacgaacg 141420 gacttcgtgt ggcaggagcg cgcggccgtg gttaaccgga gtctggttat tcacggggtc 141480 cgagagacgg acagcggcct gtataccctg tccgtgggcg acataaagga cccggctcgc 141540 caagtggcct cggtggtcct ggtggtgcaa ccggccccag ttccgacccc acccccgacc 141600 ccagccgatt acgacgagga tgacaatgac gagggcgagg acgaaagtct cgccggcact 141660 cccgccagcg ggaccccccg gctcccgcct ccccccgccc ccccgaggtc ttggcccagc 141720 gcccccgaag tctcacatgt gcgtggggtg accgtgcgta tggagactcc ggaagctatc 141780 ctgttttccc ccggggagac gttcagcacg aacgtctcca tccatgccat cgcccacgac 141840 gaccagacct actccatgga cgtcgtctgg ttgaggttcg acgtgccgac ctcgtgtgcc 141900 gagatgcgaa tatacgaatc gtgtctgtat cacccgcagc tcccagaatg tctgtccccg 141960 gccgacgcgc cgtgcgccgc gagtacgtgg acgtctcgcc tggccgtccg cagctacgcg 142020 gggtgttcca gaacaaaccc cccaccgcgc tgttcggccg aggctcacat ggagcccgtc 142080 ccggggctgg cgtggcaggc ggcctccgtc aatctggagt tccgggacgc gtccccacaa 142 140 cactccggcc tgtatctgtg tgtggtgtac gtcaacgacc atattcacgc ctggggccac 142200 attaccatca gcaccgcggc gcagtaccgg aacgcggtgg tggaacagcc cctcccacag 142 260 cgcggcgcgg atttggccga gcccacccac ccgcacgtcg gggcccctcc ccacgcgccc 142320 ccaacccacg gcgccctgcg gttaggggcg gtgatggggg ccgccctgct gctgtctgcg 142380 ctggggttgt cggtgtgggc gtgtatgacc tgttggcgca ggcgtgcctg gcgggcggtt 142440 aaaagcaggg cctcgggtaa ggggcccacg tacattcgcg tggccgacag cgagctgtac 142500 gcggactgga gctcggacag cgagggagaa cgcgaccagg tcccgtggct ggcccccccg 142560 gagagacccg actctccctc caccaatgga tccggctttg agatcttatc accaacggct 142620 ccgtctgtat acccccgtag cgacgggcat caatctcgcc gccagctcac aacctttgga 142680 tccggaaggc ccgatcgccg ttactcccag gcctccgatt cgtccgtctt ctggtaaggc 142740 gccccatccc gaggccccac gtcggtcgcc gaactgggcg accgccggcg aggtggacgt 142800 cggagacgag ctaatcgcga tttccgacga acgcggaccc ccccgacatg accgcccgcc 142860 cctcgccacg tcgaccgcgc cctcgccaca cccgcgaccc ccgggctaca cggccgttgt 142920 ctccccgatg gccctccagg ctgtcgacgc cccctccctg tttgtcgcct ggctggccgc 142980 tcggtggctc cggggggctt ccggcctggg ggccgtcctg tgtgggattg cgtggtatgt 143040 gacgtcaatt gcccgaggcg cacaaagggc cggtggtccg cctagccgca gcaaattaaa 143 100 aatcgtgagt cacagcgacc gcaacttccc acccggagct ttcttccggc ctcgatgacg 143 160 tcccggctct ccgatcccaa ctcctcagcg cgatccgaca tgtccgtgcc gctttatccc 143220 acggcctcgc cagtttcggt cgaagcctac tactcggaaa gcgaagacga ggcggccaac 143280 gacttcctcg tacgcatggg ccgccaacag tcggtattaa ggcgttgacg cagacgcacc 143340 cgctgcgtcg gcatggtgat cgcctgtctc ctcgtggccg ttctgtcggg cggatttggg 143 400 gcgctcctga tgtggctgct ccgctaaaag accgcatcga cacgcgcgtc cttcttgtcg 143460 tctctcttcc cccccatcac cccgcaattt gcacccagcc tttaactaca ttaaattggg 143520 ttcgattggc aatgttgtct cccggttgat ttttgggtgg gtggggagtg ggtgggtggg 143580 gagtgggtgg gtggggagtg ggtgggtggg gagtgggtgg gtggggagtg ggtgggtggg 143640 gagtgggtgg gtggggagtg ggtgggtggg gagtgggtgg gtggggagtg ggtgggtggg 143700 gagtggcaag gaagaaacaa gcccgaccac cagacagaaa atgtaaccat acccaaaccg 143760 actctggggg ctgtttgtgg ggtcggaacc ataggatgaa caaaccaccc cgtacctccc 143820 gcacccaagg gtgcgggtgg ctcatcggca tctgtccggt atgggttgtt ccccacccac 143880 tcgcgttcgg acgtcttaga atcatggcgg ttttctatgc cgacatcggt tttctccccc 143940 gcaataagac acgatgcgat aaaatctgtt tgtaaaattt attaagggta caaattgccc 144000 tagcacaggg gtggggttag ggccgggtcc ccacacccaa acgcaccaaa cagatgcagg 144060 cagtgggtcg agtacagccc cgcgtacgaa cacgtcgatg cgtgtgtcag acagcaccag 144 120 aaagcacagg ccatcaacag gtcgtgcatg tgtcggtggg tttggacgcg gggggccatg 144180 gtggtgataa agttaatggc cgccgtccgc cagggccaca ggggcgacgt ctcttggttg 144240 gcccggagcc actgggtgtg gaccagccgc gcgtggcggc ccaacatggc ccctgtagcc 144300 gggggcgggg gatcgcgcac gtttgcagcg cacatgcgag acacctcgac cacggttcga 144360 aagaaggccc ggtggtccgc gggcaacatc accaggtgcg caagcgcccg ggcgtccaga 144420 gggtagagcc ctgagtcatc cgaggttggc tcatcgcccg ggtcttgccg caagtgcgtg 144480 tgggttgggc ttccggtggg cgggacgcga accgcggtgt ggatcccgac gcgggcccga 144540 gcgtatgctc catcttgtgg ggagaagggg tctgggctcg ccaggggggc atacttgccc 144600 gggctataca gacccgcgag ccgtacgtgg ttcgcggggg gtgcgtgggg tccggggctc 144660 cctgggagac cggggttgtc gtggatccct ggggtcacgc ggtaccctgg ggtctctggg 144720 agctcgcggt actctgggtt ccctaggttc tcggggtggt cgcggaaccc ggggctcccg 144780 gggaacacgc ggtgtcctgg ggattgttgg cggtcggacg gcttcagatg gcttcgagat 144840 cgtagtgtcc gcaccgactc gtagtagacc cgaatctcca cattgccccg ccgcttgatc 144900 attatcaccc cgttgcgggg gtccggagat catgcgcggg tgtcctcgag gtgcgtgaac 144960 acctctgggg tgcatgccgg cggacggcac gccttttaag taaacatctg ggtcgcccgg 145020 cccaactggg gccgggggtt gggtctggct catctcgaga gacacggggg ggaaccaccc 145080 tccgcccaga gactcgggtg atggtcgtac ccgggactca acgggttacc ggattacggg 145 140 gactgtcggt cacggtcccg ccggttcttc gatgtgccac acccaaggat gcgttggggg 145200 cgatttcggg cagcagcccg ggagagcgca gcaggggacg ctccgggtcg tgcacggcgg 145 260 ttctggccgc ctcccggtcc tcacgccccc ttttattgat ctcatcgcgt acgtcggcgt 145320 acgtcctggg cccaacccgc atgttgtcca ggaaggtgtc cgccatttcc agggcccacg 145380 acatgctttt ccccccgacg agcaggaagc ggtccacgca acggtcgccg ccggtcgcct 145440 cgacgagggc gttcctcctg cgggaaggca cgaacgcggg tgagccccct cctccgcccc 145500 cgcgtccccc ctcctccgcc cccgcgtccc ccctcctccg cccccgcgtc ccccctcctc 145560 cgcccccgcg tcccccctcc tccgcccccg cgtcccccct cctctgccca cccaaggtgc 145620 ttacccgtgc aaaaaaggcg gaccggtggg tttctgtcgt cggaggcccc cggggtgcgt 145680 cccctgtgtt tcgtgggtgg ggtgggcggg tctttccccc ccgcgtccgc gtgtcccttt 145740 ccgatgcgat cccgatcccg agccggggcg tcgcgatgcc gacgccgtcc gctccgacgg 145800 ccctctgcga ctcccgctcc cggtccgcgt gctccgcagc cgctcccgtc gttcgtggct 145860 ggcgccgtct gcgggcgtcg gtcgcgccgg gcctttatgt gcgccggaga gacccgcccc 145920 ccgccgcccg ggtccgcccc cggggccggc gcggagtcgg gcacggcgcc agtgctcgca 145980 cttcgcccta ataatatata tatattggga cgaagtgcga acgcttcgcg ttctcacttc 146040 ttttacccgg cggccccgcc cccttggggc ggtcccgccc gccggccaat gggggggcgg 146 100 caaggcgggc ggcccaaggg ccgcccgccg tcccgttggt cccggcgtcc ggcgggcggg 146 160 accgggggcc cggggacggc caacgggcgc gcggggctcg tatctcatta ccgccgaacc 146220 gggaagtcgg ggcccgggcc ccgccccctg cccgttcctc gttagcatgc ggaacggaag 146280 cggaaaccgc cggatcgggc ggtaatgaga tgccatgcgg ggcggggcgc ggacccaccc 146340 gccctcgcgc cccgtccatg gcagatggcg cggatgggcg gggccggggg ttcgaccaac 146400 gggccgcggc cacgggcccc cggcgtgccg gcgtcggggc ggggtcgtgc ataatggaat 146460 tccgttcggg gtgggcccgc cggggggcgg ggggccggcg gcctccgctg ctcctccttc 146520 ccgccggccc ctgggactat atgagcccga ggacgccccg atcgtccaca cggagcgcgg 146580 ctgccgacac ggatccacga cccgacgcgg gaccgccaga gacagaccgt cagacgctcg 146640 ccgcgccggg acgccgatac gcggacgaag cgcgggaggg ggatcggccg tccctgtcct 146700 ttttccccac ccaagcatcg accggtccgc gctagttccg cgtcgacggc gggggtcgtc 146760 ggggtccgtg ggtctcgccc cctcccccca tcgagagtcc gtaggtgacc taccgtgcta 146820 cgtccgccgt cgcagccgta tccccggagg atcgccccgc atcggcgatg gcgtcggaga 146880 acaagcagcg ccccggctcc ccgggcccca ccgacgggcc gccgcccacc ccgagcccag 146940 accgcgacga gcggggggcc ctcgggtggg gcgcggagac ggaggagggc ggggacgacc 147000 ccgaccacga ccccgaccac ccccacgacc tcgacgacgc ccggcgggac gggagggccc 147060 ccgcggcggg caccgacgcc ggcgaggacg ccggggacgc cgtctcgtcg cgacagctgg 147 120 ctctgctggc ctccatggta gaggaggccg tccggacgat cccgacgccc gaccccgcgg 147 180 cctcgccgcc ccggaccccc gcctttctag ccgacgacga tgacggggac gagtacgacg 147 240 acgcagccga cgccgccggc gaccgggccc cggcccgggg ccgcgaacgg gaggccccgc 147 300 tacgcggcgc gtatccggac cccacggacc gcctgtcgcc gcgcccgccg gcccagccgc 147360 cgcggagacg tcgtcacggc cggcggcggc catcggcgtc atcgacctcg tcggactccg 147420 ggtcctcgtc ctcgtcgtcc gcatcctctt cgtcctcgtc gtccgacgag gacgaggacg 147480 acgacggcaa cgacgcggcc gaccacgcac gcgaggcgcg ggccgtcggg cggggtccgt 147540 cgagcgcggc gccggaagcc cccgggcgga cgccgccccc gcccgggcca ccccccctct 147600 ccgaggccgc gcccaagccc cgggcggcgg cgaggacccc cgcggcctcc gcgggccgca 147660 tcgagcgccg ccgggcccgc gcggcggtgg ccggccgcga cgccacgggc cgcttcacgg 147 720 ccgggcagcc ccggcgggtc gagctggacg ccgacgcggc ctccggcgcc ttctacgcgc 147780 gctatcgcga cgggtacgtc agcggggagc cgtggcccgg cgccgggccc ccgcccccgg 147840 ggcgggtgct gtacggcggc ctgggcgaca gccgcccggg cctctggggg gcgcccgagg 147900 cggaggaggc gcgacgccgg ttcgaggcct cgggcgcccc ggcggccgtg tgggcgcccg 147960 agctgggcga cgccgcgcag cagtacgccc tgatcacgcg gctgctgtac accccggacg 148020 cggaggccat ggggtggctc cagaacccgc gcgtggtccc cggggacgtg gcgctggacc 148080 aggcctgctt ccggatctcg ggcgccgcgc gcaacagcag ctccttcatc accggcagcg 148 140 tggcgcgggc cgtgccccac ctgggctacg ccatggcggc cggccgcttc ggctggggcc 148200 tggcgcacgc ggcggccgcc gtggccatga gccgccgata cgaccgcgcg cagaagggct 148260 tcctgctgac cagcctgcgc cgcgcctacg cgcccctgtt ggcgcgcgag aacgcggcgc 148320 tgacgggggc cgcggggagc cccggcgccg gcgcagatga cgagggggtc gccgccgtcg 148380 ccgccgccgc accgggcgag cgcgcggtgc ccgccgggta cggcgccgcg gggatcctcg 148440 ccgccctggg gcggctgtcc gccgcgcccg cctcccccgt ggggggcgac gaccccgacg 148500 ccgcccgcca cgccgacgcc gacgccgggc gccgcgccca ggccggccgc gtggccgtcg 148560 agtgcctggc cgcctgccgc gggatcctgg aggcgctggc cgagggcttc gacggcgacc 148620 tggcggccgt cccggggctg gccggggccc ggcccgccag ccccccgcgg ccggagggac 148680 ccgcgggccc cgcttccccg ccgccgccgc acgccgacgc gccccgcctg cgcgcgtggc 148740 tgcgcgagct gcggttcgtg cgcgacgcgc tggtgctcat gcgcctgcgc ggggacctgc 148800 gcgtggccgg cggcagcgag gccgccgtgg ccgccgtgcg cgccgtgagc ctggtcgccg 148860 gggccctggg ccccgcgctg ccgcgggacc cgcgcctgcc gagctccgcg gccgccgccg 148920 ccgcggacct gctgtttgag aaccagagcc tccgccccct gctggcggcg gcggccagcg 148980 caccggacgc cgccgacgcg ctggcggccg ccgccgcctc cgccgcgccg cgggaggggc 149040 gcaagcgcaa gagtcccggc ccggcccggc cgcccggagg cggcggcccg cgacccccga 149 100 agacgaagaa gagcggcgcg gacgcccccg gctcggacgc ccgcgccccc ctccccgcgc 149 160 ccccctccac gcccccgggg cccgagccca cccccgccca gcccgcggcg gcccggggcg 149220 ccgcggcgca ggcccgcccg cgccccgtgg cgctgtcgcg ccggcccgcc gagggccccg 149280 accccctggg cggctggcgg cggcagcccc gggggcccag ccacacggcg gcgcccgcgg 149340 ccgccgccct ggaggcctac tgctccccgc gcgccgtggc cgagctcacg gaccacccgc 149400 tgttccccgt cccctggcga ccggccctca tgtttgaccc gcgggccctg gcctcgatcg 149460 ccgcgcggtg cgccgggccc gcccccgccg cccaggccgc gtgcggcggc gacgacgacg 149520 agaaccccca cccccacggg gccgccgggg gccgcctctt tggccccctg cgcgcctcgg 149580 gcccgctgcg ccgcatggcg gcctggatgc gccagatccc cgaccccgag gacgtgcgcg 149640 tggtggtgct gtactcgccg ctgccgggcg aggacctggc cggcggcggg gcctcggggg 149700 ggccgccgga gtggtccgcc gagcgcggcg ggctgtcctg cctgctggcg gccctggcca 149760 accggctgtg cgggccggac acggccgcct gggcgggcaa ctggaccggc gcccccgacg 149820 tgtcggcgct gggcgcgcag ggcgtgctgc tgctgtccac gcgggacctg gccttcgccg 149880 gggccgtgga gtttctgggg ctgctcgcca gcgccggcga ccggcggctc atcgtggtca 149940 acaccgtgcg cgcctgcgac tggcccgccg acgggcccgc ggtgtcgcgg cagcacgcct 150000 acctggcgtg cgacctgctg cccgccgtgc agtgcgccgt gcgctggccg gcggcgcggg 150060 acctgcgccg cacggtgctg gcctcgggcc gcgtgttcgg cccgggggtc ttcgcgcgcg 150 120 tggaggccgc gcacgcgcgc ctgtaccccg acgcgccgcc gctgcgcctg tgccgcggcg 150 180 gcaacgtgcg ctaccgcgtg cgcacgcgct tcggcccgga cacgccggtg cccatgtccc 150 240 cgcgcgagta ccgccgggcc gtgctgccgg cgctggacgg ccgggcggcg gcctcgggga 150 300 ccaccgacgc catggcgccc ggcgcgccgg acttctgcga ggaggaggcc cactcgcacc 150 360 gcgcctgcgc gcgctggggc ctgggcgcgc cgctgcggcc cgtgtacgtg gcgctggggc 150 420 gcgaggcggt gcgcgccggc ccggcccggt ggcgcgggcc gcggagggac ttttgcgccc 150 480 gcgccctgct ggagcccgac gacgacgccc ccccgctggt gctgcgcggc gacgacgacg 150 540 acggcccggg ggccctgccg ccggcgccgc ccgggattcg ctgggcctcg gccacgggcc 150 600 gcagcggcac cgtgctggcg gcggcggggg ccgtggaggt gctgggggcg gaggcgggct 150 660 tggccacgcc cccgcgacgg gacgttgtgg actgggaagg cgcctgggac gaagacgacg 150 720 gcggcgcgtt cgagggggac ggggtgctgt aacgggccgg gacggggcgg ggcgcttgtg 150780 aaacccgaag acgcaataaa cggcaacgac ctgattaagt tttgcagtag cgttgtttat 150840 tcgaggggcg ggagggggcg aggggcggga gggggcgagg ggcgggaggg ggcgaggggc 150 900 gggagggggc gaggggcggg agggggcgag gggcgggagg gggcgagggg cgggaggggg 150 960 cgaggggcgg gagggggcga ggggcgggag ggggcgaggg gcgggagggg gcgaggggcg 151020 ggagggggcg aggggcggga gggggcgagg ggcgggaggg ggcgaggggc gggagggggc 151080 gaggggcggg agggggcgag gggcgggagg gggcgagggg cgggaggggg cgaggggcgg 151 140 gagggggcga ggggcgggag ggggcgaggg gcggtggtgg tgcgcgggcg cccccggagg 151200 gtttggatct ctgacctgag attggcggca ctgaggtaga gatgcccgaa cccccccgag 151 260 ggagcgcggg acgcggctgg ggagggctgg ggctggggag ggctggggcc ggggagggct 151320 ggggccgggg agggctgggg ccggggaggg ctggggccgg ggagggctgg ggccggggag 151380 ggctggggct ggggagggct ggggctgggg aggggcggtg gtgtgtagca ggagcggtgt 151440 gttgcgccgg ggtacgtctg gaggagcggg aggtgcgcgg tgacgtgtgg atgaggaaca 151500 ggagttgttg cgcggtgagt tgtcgctgtg agttgtgttg ttgggcaggt gtggtggatg 151560 acgtgacgtg tgacgtgcgg attgcgccgt gctttgttgg tgttgtttta cctgtggcag 151620 cccgggcccc ccgcgggcgc gcgcgcgcgc aaaaaaggcg ggcggcggtc cgggcggcgt 151680 gcgcgcgcgc ggcgggcgtg gggggcgggg ccgcgggagc gggggaggag cgggggagga 151740 gcggggggag gagcgggggg aggagcgggg ggaggagcgg ggggaggagc ggggggagga 151800 gcggggggag gagcgggggg aggagcgggg ggaggagcgg ggggaggagc ggggggagga 151860 gcggggggag gagcgggggg aggagcgggg ggaggagcgg ggggaggagc ggggggagga 151920 gcgggggagg agcggccaga ccccggaaac gggccccccc caaaacacac cccccggggg 151980 tcgcgcgcgg ccctttaaag gcgggcggcg g 152011 <210> 2 <211> 15 <212> DNA <213> GM-CFS Primer 1 <400> 2 atgttgtcgt cgccg 15 <210> 3 <211> 17 <212> DNA <213> GM-CFS Primer 2 <400> 3 gtggcattcg ggggaac 17

Claims (1)

Shuttle vector for HSV-1 recombination comprising a nucleotide sequence from which a region of an infected-cell protein 6 (ICP6) gene derived from Herpes Simplex Virus 1 (HSV-1) is deleted, wherein the region is a nucleotide of SEQ ID NO: 1 86,901 to 89,573 sequences of the sequence, the nucleotide sequence further comprises a partial nucleotide sequence of a UL38 (Unique Long 38) gene at the 3 'end, and further comprises a partial nucleotide sequence of the UL40 or UL41 gene at the 5' end, A shuttle vector into which a gene for treatment of cancer is inserted, and a shuttle vector into which a granulocyte-macrophage colony-stimulating factor (GM-CSF) is inserted.

Images