KR101949451B1 - 염증성 장 질환 및 아토피 피부염 치료용 조성물 - Google Patents

염증성 장 질환 및 아토피 피부염 치료용 조성물 Download PDF

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KR101949451B1
KR101949451B1 KR1020160131313A KR20160131313A KR101949451B1 KR 101949451 B1 KR101949451 B1 KR 101949451B1 KR 1020160131313 A KR1020160131313 A KR 1020160131313A KR 20160131313 A KR20160131313 A KR 20160131313A KR 101949451 B1 KR101949451 B1 KR 101949451B1
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atopic dermatitis
ips
ncs
dncb
active ingredient
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English (en)
Korean (ko)
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KR20170043457A (ko
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강인철
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주식회사 이노파마스크린
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Priority to JP2018519833A priority Critical patent/JP6885607B2/ja
Priority to US15/768,374 priority patent/US10278931B2/en
Priority to EP16855712.2A priority patent/EP3363783B1/en
Priority to HK18113385.6A priority patent/HK1254242B/zh
Priority to PCT/KR2016/011434 priority patent/WO2017065495A2/ko
Priority to CN201680059836.6A priority patent/CN108137490B/zh
Publication of KR20170043457A publication Critical patent/KR20170043457A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/06—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/332—Promoters of weight control and weight loss
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020160131313A 2015-10-13 2016-10-11 염증성 장 질환 및 아토피 피부염 치료용 조성물 Expired - Fee Related KR101949451B1 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2018519833A JP6885607B2 (ja) 2015-10-13 2016-10-12 炎症性腸疾患およびアトピー性皮膚炎の処置のための組成物
US15/768,374 US10278931B2 (en) 2015-10-13 2016-10-12 Composition for treatment of inflammatory bowel disease and atopic dermatitis
EP16855712.2A EP3363783B1 (en) 2015-10-13 2016-10-12 Composition for treatment of inflammatory bowel disease and atopic dermatitis
HK18113385.6A HK1254242B (zh) 2015-10-13 2016-10-12 用於治疗炎性肠病和异位性皮炎的组合物
PCT/KR2016/011434 WO2017065495A2 (ko) 2015-10-13 2016-10-12 염증성 장 질환 및 아토피 피부염 치료용 조성물
CN201680059836.6A CN108137490B (zh) 2015-10-13 2016-10-12 用于治疗炎性肠病和异位性皮炎的组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20150142929 2015-10-13
KR1020150142929 2015-10-13

Related Child Applications (1)

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KR1020170155266A Division KR101901895B1 (ko) 2015-10-13 2017-11-21 염증성 장 질환 및 아토피 피부염 치료용 조성물

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KR20170043457A KR20170043457A (ko) 2017-04-21
KR101949451B1 true KR101949451B1 (ko) 2019-05-10

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KR1020160131313A Expired - Fee Related KR101949451B1 (ko) 2015-10-13 2016-10-11 염증성 장 질환 및 아토피 피부염 치료용 조성물
KR1020170155266A Active KR101901895B1 (ko) 2015-10-13 2017-11-21 염증성 장 질환 및 아토피 피부염 치료용 조성물

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Country Status (5)

Country Link
US (1) US10278931B2 (cg-RX-API-DMAC7.html)
EP (1) EP3363783B1 (cg-RX-API-DMAC7.html)
JP (1) JP6885607B2 (cg-RX-API-DMAC7.html)
KR (2) KR101949451B1 (cg-RX-API-DMAC7.html)
CN (1) CN108137490B (cg-RX-API-DMAC7.html)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
KR101949451B1 (ko) * 2015-10-13 2019-05-10 주식회사 이노파마스크린 염증성 장 질환 및 아토피 피부염 치료용 조성물
EP4467565A3 (en) 2016-12-21 2025-03-12 Amgen Inc. Anti-tnf alpha antibody formulations
JP2021536467A (ja) 2018-09-06 2021-12-27 インノファーマスクリーン インコーポレイテッド 喘息またはパーキンソン病の処置のための方法および組成物
CN114681438B (zh) * 2022-05-17 2024-03-19 中国医学科学院基础医学研究所 二甲双胍及其它含胍化合物在逆转Gal-10结晶趋势并缓解相关疾病中应用
CN119970807A (zh) * 2025-03-07 2025-05-13 中国人民解放军总医院第一医学中心 Tslp表达水平调节剂及治疗银屑病的药物和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037346A1 (en) * 2001-10-31 2003-05-08 Cell Therapeutics, Inc. 6-phenyl-n-phenyl-(1,3,5) -triazine-2,4-diamine derivatives and related compounds with lysophphosphatidic acid acyltransferase beta (lpaat-beta) inhibitory activity for use in the treatment of cancer
US20130095140A1 (en) * 2011-01-07 2013-04-18 Elcelyx Therapeutics, Inc. Biguanide Compositions and Methods of Treating Metabolic Disorders
KR101901895B1 (ko) * 2015-10-13 2018-09-27 주식회사 이노파마스크린 염증성 장 질환 및 아토피 피부염 치료용 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2004005509A1 (ja) 2002-07-02 2005-11-04 株式会社ジェノックス創薬研究所 アレルギー性疾患の検査方法、および治療のための薬剤
US20110263901A1 (en) 2008-01-23 2011-10-27 Dhananjay Govind Sathe Process of Preparation of Proguanil
EP2273974A2 (en) * 2008-05-09 2011-01-19 Tolmar, Inc. Proguanil to treat skin/mucosal diseases
CN102725264B (zh) 2010-01-06 2014-12-17 韩诺生物制药株式会社 双胍衍生物、其制备方法以及包含其作为活性成分的药物组合物
SG10201901922VA (en) * 2012-01-06 2019-04-29 Elcelyx Therapeutics Inc Compositions and methods for treating metabolic disorders
WO2015026215A1 (ko) 2013-08-23 2015-02-26 가톨릭대학교 산학협력단 바이구아나이드 유도체 화합물을 유효성분으로 포함하는 면역질환 또는 염증질환의 예방 또는 치료용 약제학적 조성물
CA2946516C (en) 2014-04-29 2022-02-01 The Catholic University Of Korea Industry-Academic Cooperation Foundation Compound having immune disease treatment effect and use thereof
WO2015167243A1 (ko) * 2014-04-29 2015-11-05 가톨릭대학교 산학협력단 면역질환 치료효과를 갖는 신규한 화합물 및 이의 용도
KR102216701B1 (ko) 2014-11-20 2021-02-18 이뮤노메트테라퓨틱스 인코포레이티드 바이구아나이드 화합물 및 이의 용도

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037346A1 (en) * 2001-10-31 2003-05-08 Cell Therapeutics, Inc. 6-phenyl-n-phenyl-(1,3,5) -triazine-2,4-diamine derivatives and related compounds with lysophphosphatidic acid acyltransferase beta (lpaat-beta) inhibitory activity for use in the treatment of cancer
US20130095140A1 (en) * 2011-01-07 2013-04-18 Elcelyx Therapeutics, Inc. Biguanide Compositions and Methods of Treating Metabolic Disorders
KR101901895B1 (ko) * 2015-10-13 2018-09-27 주식회사 이노파마스크린 염증성 장 질환 및 아토피 피부염 치료용 조성물

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chemical Abstract 화합물, STN express. RN 300382-90-5 (Entered STN: 2000.10.30. 공개)*

Also Published As

Publication number Publication date
KR101901895B1 (ko) 2018-09-27
EP3363783A2 (en) 2018-08-22
JP2018536638A (ja) 2018-12-13
US10278931B2 (en) 2019-05-07
JP6885607B2 (ja) 2021-06-16
EP3363783A4 (en) 2019-05-29
KR20170131325A (ko) 2017-11-29
CN108137490A (zh) 2018-06-08
US20180303774A1 (en) 2018-10-25
EP3363783B1 (en) 2021-12-08
HK1254242A1 (zh) 2019-07-12
CN108137490B (zh) 2021-09-03
KR20170043457A (ko) 2017-04-21

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