KR101920023B1 - Composition comprising Cassia obtusifolia L. and Foeniculum vulgare Mill for improving constipation - Google Patents

Abstract

The present invention relates to a composition for improving constipation comprising a combination of a catechin and a fennel mixed extract.
According to the present invention, in the case of the Cassiae and Fennel mixed extract, constipation can be improved by smoothly functioning as a bowel.

Description

Composition comprising Cassia obtusifolia L. and Foeniculum vulgare Mill for improving constipation < RTI ID = 0.0 >

The present invention relates to a composition for improving constipation comprising a defatted part and a fennel, and more particularly to a composition for improving constipation, which comprises a mixture of a defatted parthenocarp extract and a fennel extract.

The ingested food is excreted through the stomach, small intestine and colon through the anus. The food is digested, most of it is absorbed in the small intestine, and it is decomposed and excreted by intestinal bacteria. When the functions are properly maintained, the Food and Drug Administration defines it as a healthy field.

The function of health functional foods which help to intestinal health to date is divided into three categories. First, functional improvement of bowel activity, improvement of bowel movement, improvement of bowel frequency, drainage time and improvement of side water . Second, it is a function to promote the growth of beneficial bacteria in the intestines and to inhibit harmful bacteria. In case of intestinal beneficial bacteria, beneficial bacteria are increased in intestinal microflora and the number of harmful bacteria is suppressed. Third, improvement of intestinal health through immune function regulation is the improvement of inflammation induction by immunological index and cytokine change.

The market for functional foods for intestinal health has been steadily growing. In particular, red ginseng, the number one producer, has been steadily declining recently, but probiotic products, which are intestinal health functional ingredients, are growing at a rapid rate of 55%, from 51.8 billion won to 50.4 billion won , And the market for fermented milk is currently worth 300 billion won. Probiotics, aloe, and dietary fiber products, which are related to intestinal health, are the second largest producers of health functional foods. According to the Korea Food and Drug Administration (KFDA), the market for functional foods for intestinal health is increasing, but imports of most functional food ingredients including probiotics, aloe and dietary fiber are expected to rise from KRW 204 billion in 2009 to KRW 380 billion in 2013 However, since most functional food ingredients depend on overseas imports, it is urgent to conduct domestic research on health functional food ingredients using intestinal health using natural resources.

Constipation is defined as the passage of waste at the lower part of the colon is delayed, so the stool is discharged into the anus with less water. In the case of a decrease in bowel movements, incomplete drainage or difficulty of drainage may result in a decrease in the number of normal bowel movements or excretion of stiff and dry stools, which makes it difficult to keep bowel movements constantly, Constipation is a series of functional disorders in which symptoms occur. Common causes are diarrhea due to complex lifestyle factors such as increased life stress in modern people, irregular Western eating habits, and lack of exercise. Constipation patients often do not promptly treat constipation because most constipation patients do not consider constipation itself a serious disease.

Especially, in recent years, elderly constipation patients are rapidly increasing due to lack of exercise due to aging and limitation of joints. In the case of geriatric constipation, colonic muscle relaxation due to aging, adverse drug reactions due to aging complications, underlying underlying diseases, erroneous bowel habits, and lack of fiber cause bowel movements to weaken and cause constipation. If left untreated, the risk of cardiovascular disease such as incontinence, hemorrhoids, colon cancer, and stroke may increase.

Cassia obtusifolia L. has been used for a long time, for example, as a formulary, emollient, diuretic, night blindness, glaucoma, hepatitis, enteritis and hyperlipidemia. Chrysophanol, emodin, aloe-emodin, rhein, physcion, obtusin, cassiaside, Is known.

Feniculum vulgare (Foeniculum vulgare Mill) is known to be effective in the treatment of tongue, dryness, inflammation, appetite suppression, diuretic, obesity, etc., and effective ingredients such as limonene, pinene, terpinene, fenchone and anethole are known.

Conventionally, the improvement effect of constipation alone or combination of herbal remedy extracts (Korean Patent No. 10-0427562, Korean Patent No. 10-0512322) is known, but the effect of improving penicillin alone or improving the constipation Is not known.

Dietary fiber, which is a functional food related to intestinal health, has a large daily intake on an adult basis and is not greatly improved. In addition, probiotics products are subject to problems due to inadequate labeling, side effects, and sterilization of limited products, and they are also dependent on imported raw materials. Therefore, it is necessary to develop functional food with constipation improvement which has few side effects using domestic plant resources, and it is urgent to develop various kinds of products customized considering consumer desire and age.

The inventors of the present invention have conducted intensive researches to overcome the problems of the prior arts. As a result, the inventors of the present invention have found that constipation improvement compositions including a cleanser and a fennel extract mixture can improve constipation by facilitating intestinal function, Thereby completing the invention.

KR 10-0427562 B KR 10-0512322 B

Accordingly, it is a main object of the present invention to provide a composition for improving constipation comprising a cleanser and a penne which can improve constipation by smoothly functioning as a bowel.

According to one aspect of the present invention, there is provided a composition for improving constipation comprising a phenol extract as an active ingredient.

Feniculum vulgare (Feniculum vulgare Mill) is known to be effective for bowel, rectal, inflammation, appetite suppression, diuretic, obesity treatment, but the effect of improving constipation is not known. However, according to the embodiment of the present invention, the Fennel extract showed better improvement in constipation such as the number of sides and the weight of the stomach than the Cassiae extract.

In the present invention, there is preferably provided a composition for improving constipation comprising an active ingredient of a cuttlefish and a fennel extract mixture.

Cassia obtusifolia L. has been used for a long time in formal, emollient, diuretic, night blindness, glaucoma, hepatitis, enteritis, and hyperlipemia. In addition, it is known that the effect of improving the constipation by the single or the mixed extract of the defensin has not been known. Thus, the inventors of the present invention have found that the defatted or penne extract mixture is more effective for improving constipation than the defatted or penne extract alone, and thus completed the present invention.

In the present invention, the Cassiae and Fennel extract mixtures are preferably prepared by mixing Cassiae and Fennel extracts at a weight ratio of 8: 2 to 2: 8, most preferably 5: 5. ≪ / RTI >

According to the embodiment of the present invention, when the Cassiae Extract and Fenel Extract were mixed at a weight ratio of 5: 5, the constipation improvement effect was remarkably improved in all parts including the number of sides, the weight of the sides, and the moisture content of the sides.

In the present invention, the extract is obtained by solvent extraction with water, ethanol or a mixed solvent thereof, or extraction with distillation or pressing. The above-mentioned ethanol is preferably a drinking water which is recognized as a solvent for extracting health functional foods in a food processing plant.

Preferably, the cuttlefish and the Fennel extract are preferably extracted at 60 to 100 ° C in water, ethanol or a mixed solvent thereof, more preferably 85 to 95 ° C in the case of water extract, 65 Lt; RTI ID = 0.0 > 75 C < / RTI >

In the present invention, the extract is powdered or granulated to provide a composition for improving constipation. The tea composition can be commercialized, for example, as a tea bag product, and can be easily dissolved in water.

In the case of pulverization, the extract is preferably spray-dried (SD) at 70 to 95 ° C, more specifically, sprayed at 85 to 95 ° C for water extracts and 65 to 75 ° C for ethanol extracts. dry (SD) powder is preferable.

In the case of granulation, the powder is added with purified water, kneaded, passed through a 12-20 mesh screen using an extrusion granulator, and a granule is obtained. The granule is dried in an oven at 40 to 45 ° C for 4 to 5 hours, .

In the present invention, the composition is prepared in the form of a powder, a granule, a tablet, a capsule or a suspension. The composition may be commercialized in the form of a health functional food.

The composition of the present invention may be taken into the oral cavity in the form of a tea, a beverage or a health functional food. In this case, the mixed extract according to the present invention is preferably administered in an amount of 100 to 600 mg / kg body weight to improve constipation.

INDUSTRIAL APPLICABILITY As described above, according to the present invention, the Fennel extract is more effective in improving the constipation such as the number of sides and the weight of the stomach than the Cassiae extract, and the extract mixture of the Cassiae and Fennel is more effective than the Cassia or Fennel alone extract, The improvement effect was more excellent. Therefore, in the case of the cuttlefish and the Fennel extract mixture according to the present invention, the most effective improvement of constipation can be utilized as a raw material for functional food for improving intestinal health.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a graph showing the results of measurement of the number of sides in an SD rat for determining the mixing ratio of a scabbard and a fennel extract. FIG.
Fig. 2 is a graph showing the results of measurement of the weight (g) of the stool in SD rats for determining the mixing ratio of the scallop and the fennel extract.
FIG. 3 is a graph showing the results of measurement of the dry stool weight (g) in an SD rat to determine the mixing ratio of the Cretace fruit and the Fennel extract.
FIG. 4 is a graph showing the results of water content (%) measurement on the side of SD rats for determining the mixing ratio of Cetacea and Fennel extracts.
FIG. 5 is a graph showing intrinsic parameters (number of rat feces in colon) in SD rats for determining the dose of a CRESTOR and penneel mixture.
FIG. 6 is a graph showing the colon weight (g) in an SD rat for determining the dose of a CRESTOR and a penneule mixture.
FIG. 7 is a graph showing the travel distance (cm) of barium sulphate in an SD rat for determining the dose of a CRESTOR and a penneel mixture.
FIG. 8 is a graph showing the colon length (cm) in an SD rat for determining the dose of a CRESTOR and a penneule mixture.
FIG. 9 is a graph showing the Rat of digestive tract transfer (%) in SD rats to determine the dose of the CRESTOR and FENNEL mixture.

Hereinafter, the present invention will be described in more detail with reference to Examples. These embodiments are only for illustrating the present invention, and thus the scope of the present invention is not construed as being limited by these embodiments.

Example 1: Preparation of Cucumber and Fennel Extracts

The cutter, Fennel used in this experiment was extracted and concentrated under the following conditions without pulverization and spray dried (SD) powdered. Specifically, 70% of the liquor was added to 8% of the raw material, and the mixture was extracted at 70 ° C for 3 hours and then filtered. An additional 8 times of 70% alcohol was added to the residue after filtration, followed by secondary extraction . The extract was extracted twice and 40% of excipient was added to obtain powder through SD. Fennel was subjected to hot water extraction using water. Ten times more water was extracted at 95 ~ 100 ℃ for 1.5 hours. After filtration, the residue was extracted twice more times under the same conditions and extracted 3 times. The extracted extract was concentrated to 40 brix to obtain a powder through SD.

In order to compare constipation-improving efficacy of the powdered Celestial Solitary Extract, Fenel Solely Extract, and Celery Extract and Fenel Extract Mixture, the respective extracts or mixtures were quantified by the same amount, Respectively.

Experimental Example  1: With the loser Fennel  Determination of mixing ratio of extract

1) Test method

  - In order to compare the efficacy of the test materials, the effect of improving the constipation according to the ratio of each and the combination of testosterone and penelin was examined by mixing 8: 2, 7: 3, 5: 5, 3: 7 and 2:

  Six weeks old SD rats were divided into 10 groups (normal group, test group, negative control group, positive control group) and cage adapted for 1 week. Loperamide (2 mg / kg) and sample (300 mg / kg) were administered for 3 days .

  - Number of stools, side weight, and water content were measured once a day. Autopsy was performed on day 4, and intestinal variables and migration length of stools were measured.

2) Test result

Increasing the bulk of the stools reflects an improvement in bowel movements as the intestinal motility of the bowel is promoted and the drain time is reduced. The amount of stool is evaluated by the number of stools, pre-drying stool weight and dry stool weight.

Variation Contains moderate moisture, softens and improves bowel activity. Normal water content is 70-80%, and people with constipation symptoms have a hard side with less than 70% water content. To evaluate the effect of water content on the experimental rat, the normal and negative control groups were compared.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a graph showing the results of measurement of the number of sides in an SD rat for determining the mixing ratio of a scabbard and a fennel extract. FIG. The number of stools was more effective than that of the group treated with single - handed cuteness.

Fig. 2 is a graph showing the results of measurement of the weight (g) of the stool in SD rats for determining the mixing ratio of the scallop and the fennel extract. The weight of the stool was higher in the group of 5: 5 and 2: 8 mixture of penicillin and penneol than in the penicillin alone group, and the positive control group had higher effect than the control group. 5 was the most effective.

FIG. 3 is a graph showing the results of measurement of the dry stool weight (g) in an SD rat to determine the mixing ratio of the Cretace fruit and the Fennel extract. Dry varieties showed the highest effect in the group of 5: 5 and 2: 8 mixture of the donor and the fennel and in the group treated with Fenel alone.

FIG. 4 is a graph showing the results of water content (%) measurement on the side of SD rats for determining the mixing ratio of Cetacea and Fennel extracts. The water content of the sides was higher than that of the control group and the combination of 5: 5 of the penicillin and the control group.

From the results of the above test, it can be deduced that the cleanser increases the moisture content of the sides and increases the dry variant weight of the fennel, and it can show the best constipation improvement effect when the fennel and the fennel are mixed at 5: 5 Respectively.

Experimental Example  2: With the loser Fennel  Determination of the concentration of the mixture

 1) Test method

  - For the comparison of the efficacy according to the concentration of the test substance, the concentration of the celery and the fenel mixture was set to 100, 300 and 500 mg / kg, respectively.

  Six weeks old SD rats were divided into six groups (normal group, test group, negative control group, and positive control group) and cage adapters were provided for 1 week.

  - After the adaptation period, samples were given to the test group for 3 weeks. All rats except for the normal group were given loperamide (constipation inducer) daily for 4 weeks.

  - Intestinal parameters and barium sulphate were used to determine intestinal biomarkers during autopsy.

[Table 1]

2) Test result

When the motility of the intestines increases, the defecation progresses smoothly and the intestinal variables decrease. When the stool remains in the intestine, an unpleasant sensation due to residual sensation occurs, and gas generation due to the remnant is generated. In addition, if the mutation remains in the intestinal tract for a long time, the amount of water is decreased, which may cause the constipation to deteriorate.

The change in the weight of the bowel is a measure of whether the administered sample causes adverse effects in the bowel and is not indicative of efficacy.

Barium sulphate was used as an indicator to measure the movement distance of the intestines and is an index of the promotion of the intestinal tract. The distance traveled to Janggil is converted to evaluate the promotion effect of Jangwoondong by the moving rate.

FIG. 5 is a graph showing intrinsic parameters (number of rat feces in colon) in SD rats for determining the dose of a CRESTOR and penneel mixture. The effect of lecithin mixture on loperamide - induced experimental group was investigated. Intestinal parameters during autopsy were 0.7 ± 0.33 in normal group and 2.90 ± 0.41 in control group. It was also found that intestinal parameters were decreased in a concentration-dependent manner, with 2.60 ± 0.65 in the 100 mg / kg experimental group, 2.10 ± 0.57 in the 300 mg / kg experimental group, 1.70 ± 0.40 in the 500 mg / kg experimental group, and 0.30 ± 0.15 in the PC experimental group .

FIG. 6 is a graph showing the colon weight (g) in an SD rat for determining the dose of a CRESTOR and a penneule mixture. In the case of intestinal weights, PC and 500 mg / kg experimental group showed an increase in intestinal weight compared to other experimental groups.

FIG. 7 is a graph showing the travel distance (cm) of barium sulphate in an SD rat for determining the dose of a CRESTOR and a penneel mixture. In the range of movement of barium sulphate, the normal group was 98.37 ± 2.69 cm and the control group was 86.50 ± 4.04 cm. In the 100 mg / kg experimental group, 93.75 ± 4.98 cm and 300 mg / kg experimental group, 99.63 ± 3.39 , cm, 500 mg / kg, 101.06 ± 1.02 cm, PC, and 104.31 ± 4.25 cm, respectively.

FIG. 8 is a graph showing the colon length (cm) in an SD rat for determining the dose of a CRESTOR and a penneule mixture. There were no significant differences among the experimental groups in the Janggil - i.

FIG. 9 is a graph showing the Rat of digestive tract transfer (%) in an SD rat for determining the dose of a CRESTOR and a penneel mixture. The barium sulphate migration rate was 86.41 ± 1.08% in the normal group and 73.97 ± 2.52% in the control group, and the control group was significantly decreased compared to the normal group and 86.73 ± 100% The rate of migration was similar to that of the normal group, 3.16%, 300 mg / kg, 88.44 ± 1.86, 500 mg / kg, 87.32 ± 1.99% and 89.37 ± 1.33%, respectively.

In conclusion, according to the experimental example of the present invention, when the combination of Celecoxib and Fennel extracts were mixed at a ratio of 5: 5, the Celecoxib and Fennel extracts were more effective when mixed alone or at different mixing ratios, When 300 mg / kg or more of the mixture is provided (3.0 g / 60 kg when the human body is provided), the effect of improving constipation can be said.

Claims (6)

A composition for improving constipation, comprising an extract mixture of a cuttlefish and a fennel obtained by mixing a cuttlefish extract and a fennel extract at a weight ratio of 5: 5 as an active ingredient.
delete delete The composition for improving constipation according to claim 1, wherein the extract is solvent extracted with water, ethanol or a mixed solvent thereof, or extracted by distillation or pressing.
The composition for improving constipation according to claim 1, wherein the extract is powdered or granulated to be provided in the form of a tea composition.
The constipation-improving composition according to claim 1, wherein the composition is prepared in the form of a powder, a granule, a tablet, a tea bag or a suspension.

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