KR101909259B1 - Compound sealant syringe assembly - Google Patents

Abstract

An embodiment of the present invention relates to a sealant syringe assembly which comprises: a first syringe having a plurality of chambers and discharging a first solution made by mixing a buffer solution in one chamber with compound powder in the other chamber; a third syringe including one chamber to discharge a third solution which can react with the first solution; a base having the first and third syringes seated thereon; and a connector connecting the first syringe to the third syringe to mix the first solution with the third solution and then discharge the mixture. The compound powder having lower reactivity than the first solution is contained in the other chamber of the first syringe or the chamber of the third syringe, and the first and third solutions react to change the properties thereof so that shear storage modulus exceed shear loss modulus. The present invention is able to provide a sealant formed by a plurality of solutions mixed with a single operation.

Description

[0001] COMPOUND SEALANT SYRINGE ASSEMBLY [0002]

The present invention relates to a sealant syringe assembly.

In general, syringes are used as one of medical supplies, and are used for various purposes such as injecting contents or collecting liquids.

Such a syringe may be injected into a patient after inhaling an injection provided in a container such as an ampoule or a vial, or may be injected with a mixture of an agent other than the injection of a single injection.

In addition, the syringe is used for applying a sealant to various living tissues to a living body.

However, prior art syringe assemblies are very inconvenient to use because they require time to assemble or bond the vials containing the powdered medicament and the syringes in order to be ready for use at the medical site, There is a very difficult problem of using the assembly.

Conversely, pre-assembly of the syringe assembly prior to surgery at the medical site may be exposed to a contaminated environment and may occur due to solution reaction (e.g., cross-linking reaction) in the syringe due to shaking or careless handling, There is an accident risk that the use of the syringe itself is impossible.

In order to solve such a problem, a syringe including a plurality of chambers and containing a powder medicine and a solution is used in the syringe, but has a problem that the syringe is inadvertently mixed due to carelessness of the user.

Particularly, when various solutions are mixed to form a sealant to be injected, if the solution is mixed at an unintended timing, the sealant blocks the discharge flow path, and the use of the sealant becomes impossible.

Patent Document 1: Korean Patent No. 10-0340287 (registered on May 29, 2002)

Embodiments of the present invention have been made to solve the above-mentioned problems, and it is an object of the present invention to provide a sealant syringe assembly capable of providing a sealant formed by mixing a plurality of solutions in a single operation.

It is also intended to provide a sealant syringe assembly in which a plurality of solutions are prevented from mixing at an unintended instant.

A sealant syringe assembly according to an embodiment of the present invention includes a first syringe including a plurality of chambers and discharging a first solution formed by mixing a buffer solution of one chamber and a compound powder of the other chamber; A third syringe containing one chamber and discharging a third solution capable of reacting with the first solution; A base on which the first syringe and the third syringe are seated; And a connector for connecting the first syringe and the third syringe to mix and discharge the first solution and the third solution, wherein the connector is provided inside the other chamber of the first syringe or inside the chamber of the third syringe, 1 solution, wherein the first solution and the third solution react with each other to change the shear storage modulus so that the shear storage modulus exceeds the shear loss modulus, ≪ / RTI >

Further, the chemical reaction when mixing the first solution and the third solution can be generated immediately upon mixing.

In addition, the compound powder may be provided as a synthetic polymer of any one of poly ethylene glycol (PEG), polyvinyl alcohol (PVA), and poly ethylene imine (PEI).

In addition, the compound powder may be provided as a natural polymer of any one of chitosan, hyaluronic acid, alginate, gelatin, dextran, alpha glucan, betaglucan, chondroitin sulfate and poly glutamic acid (PGA).

The buffer solution may be distilled water or sodium chloride, potassium chloride, monosodium phosphate, Na2HPO4, monopotassium phosphate, Na2CO3, hydrochloric acid, , Borate, MES, Tris, and HEPES dissolved in an aqueous solution.

The first syringe includes three packing members provided in the first syringe; A passage provided in the inner circumferential surface of the first syringe; And a plunger for providing pressure to either of the packing members.

In addition, the first syringe and the third syringe each include a first packing member and a fourth packing member disposed closest to the connector, respectively, and the first packing member and the fourth packing member are respectively connected to the first The movement of the first solution and the third solution can be blocked so that the solution and the third solution can be ejected to the connector at the same time.

The first solution and the third solution may be formed such that after the first packing member and the fourth packing member are respectively fitted to the packing member fixing portions, the first packing member and the fourth packing member, And can be moved to the connector through grooves formed between the inner circumferential surfaces of the grooves.

In addition, when the first syringe is pressurized to the packing member through the plunger, the plurality of chambers are connected in space through the passage, and the buffer solution flows through the passage to mix .

The connector may further include: a connector body serving as a movement path of the first solution and the third solution; A first connection part connected to the first syringe; A second connection part connected to the third syringe; A connector head in which the first solution and the third solution are respectively discharged; And a nozzle coupled to an end of the connector head, the nozzle having an internal space for solution mixing and an injection hole.

The first connection part and the second connection part may include a body connection part connected to the connector body, respectively; A syringe connection portion connected to the first syringe or the third syringe; And a packing member fixing portion provided between the body connecting portion and the syringe connecting portion and provided with a plurality of protrusions therein, wherein any one of the packing members is fitted to the protrusion, The first solution or the third solution may be moved and discharged through the nozzle.

In addition, the plungers of the first syringe and the third syringe can be coupled to the plunger holder, and simultaneously apply pressure to the first syringe and the packing member of the third syringe.

The sealant syringe assembly according to the embodiment of the present invention is effective in forming a plurality of solutions by mixing in a single operation.

Also, there is an advantage that mixing of a plurality of solutions is prevented at an unintended moment.

1 is a perspective view illustrating a sealant syringe assembly according to an embodiment of the present invention.
2 is an exploded perspective view of FIG.
3 is a plan view of Fig.
4 is a side view for explaining the sealant syringe assembly of FIG.
5 is a cross-sectional view taken along line AA and BB in Fig.
FIG. 6 is an exploded perspective view showing another example of the first packing member fixing portion of FIG. 1; FIG.
7 is a perspective view illustrating a sealant syringe assembly according to another embodiment of the present invention.

Hereinafter, specific embodiments of the present invention will be described in detail with reference to the drawings.

In the following description of the present invention, detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

1 is a perspective view of a sealant syringe assembly according to an embodiment of the present invention, FIG. 2 is an exploded perspective view of FIG. 1, FIG. 3 is a plan view of FIG. 1, 5 is a cross-sectional view taken along line AA and BB in Fig. 4. Fig.

1 to 5, a sealant syringe assembly 1 according to an embodiment of the present invention includes a first syringe 10 for discharging a first solution, a second syringe 10 for discharging a second solution, A connector 30 connecting the first syringe 10 and the second syringe 20 and a base 40 on which the first syringe 10 and the second syringe 20 are seated, ).

Here, the first solution may be a solution in which a compound having a highly reactive functional group is dissolved, and the second solution may be a solution in which a compound having a functional group capable of reacting with a compound in the first solution is dissolved. The highly reactive compound of the first solution may attack the functional group of the second solution to form a chemical bond. Here, the functional group of the compound of the second solution may be less reactive than the functional group of the compound of the first solution.

For example, a highly reactive functional group is an aldehyde group (-CHO), an N-hydroxysuccinimide group (-NHS), a thiol group (-SH), a vinylsulfone group (-VS), a maleimide group, an isocyanate group Or the like, which can be used in the first solution, optionally in the second solution. In addition, the less reactive functional group can be mainly used in the second solution, and most can be an amine group (-NH 2), partially a hydroxyl group (-OH). These representative compounds containing an amine group may be poly (ethylene imine) (PEI), multi armed-PEG-amine, poly (lysine), trilysine amine, poly (allylamine)

When the first solution and the second solution are mixed, the shear storage modulus exceeds the shear loss modulus. That is, the first solution and the second solution are mixed with each other to be in a hydrogel state and can be used as a sealant. Also, the reaction of the first solution with the second solution may occur immediately upon mixing. Thus, the location and timing of the mixing of the first solution and the second solution is very important for the sealant syringe assembly.

In this embodiment, the sealant is formed by the reaction of the first solution and the second solution, and can be understood as a material used for bonding the two tissues or two parts to each other.

In the present embodiment, the compound can be understood as any compound in which an aqueous solution or a state change occurs over time in a dissolved state, and can be a polymer substance, a monomolecular substance, a compound of a polymer substance and a monomolecular substance, A compound of a polymer substance, and the like. Here, the change in the state is a phenomenon in which a reactive functional group existing in a compound is reduced or permanently lost in an aqueous solution, or a reactive functional group present in the compound self-reacts in an aqueous solution to cause self-crosslinking, To form a hydrogel.

The first syringe 10 may be provided with a plurality of chambers 15, 16 through a plurality of packing members 11, 12, 13. At this time, the plurality of packing members 11, 12, 13 may be provided inside the first syringe 10 at predetermined intervals. Each of the packing members 11, 12, and 13 may be provided with protrusions (unrepresented) at predetermined intervals. Here, the projections may be formed in the first syringe 10 to correspond to the airtightness and the mobility of the packing members 11, 12, 13.

That is, the protrusions (unrepresented marks) of the packing members 11, 12, 13 can be provided in a size corresponding to the inner diameter of the first syringe 10, Can be maintained in a closed state through the members (11, 12, 13).

The first packing member 11 is provided at a position closest to the connector 30 and the second packing member 12 and the third packing member 13 are provided in order at a predetermined interval Respectively. The space between the first packing member 11 and the second packing member 12 is the first chamber 15 and the space between the second packing member 12 and the third packing member 13 is the second chamber 15. [ And the chambers 15 and 16 are not limited to the chambers 16 and 16 and the front end of the first packing member 11 is shown as an empty space filled with the space. However, the plurality of packing members 11, 12 and 13 and the chambers 15 and 16 are not limited thereto . For example, if four packing members are provided, three chambers may be provided therethrough.

The first chamber 15 may be a space in which a compound powder that is a solid material is provided. At this time, the compound powder filled in the first chamber 15 can be isolated from the empty space located at the front end of the first packing member 11 through the first packing member 11. [

The first packing member 11 and the fourth packing member 21 to be described later are arranged such that the first solution to be mixed in the first chamber 15 and the second solution to be mixed in the third chamber 25 are discharged at an inaccurate timing To prevent it from becoming. That is, the discharge of the first solution from the first syringe 10 and the discharge of the second solution from the second syringe 20 are synchronized by the first packing member 11 and the fourth packing member 21 .

The compound powder may be provided as a synthetic polymer of any one of PEG (poly ethylene glycol), PVA (poly vinyl alcohol) and PEI (poly ethylene imine), but the compound powder provided in the first chamber 15 It is not limited. For example, it may be a natural polymer of any one of chitosan, hyaluronic acid, alginate, gelatin, dextran, alpha glucan, betaglucan, chondroitin sulfate and poly glutamic acid. Or a compound capable of forming a sealant.

The second chamber 16, which is separated from the first chamber 15 by the second packing member 12, may be a space in which the liquid material for dissolving the compound powder, i.e., the buffer solution, is provided. Specifically, the second packing member 12 seals a predetermined space inside the first syringe 10 through a protrusion (not shown), through which the buffer solution of the second chamber 16 flows into the first chamber 15 ). ≪ / RTI > At this time, the buffer solution is composed of NaCl (sodium chloride), KCl (potassium chloride), NaH2PO4 (monosodium phosphate), Na2HPO4 (disodium phosphate), KH2PO4 (monopotassium phosphate), Na2CO3 , Tris, HEPES, but the buffer solution is not limited thereto. For example, the buffer solution may be provided as distilled water.

The third packing member 13 can be moved by receiving pressure through the first plunger 17. Specifically, the pressure may be a force generated by the user's finger.

The first plunger 17 is in contact with one side of the third packing member 13 in the first syringe 10 and the other side is exposed to the outside of the first syringe 10, The pressure of the user can be transmitted to the third packing member 13 on one side. At this time, the first plunger 17 is provided with a smaller diameter than the inner diameter of the first syringe 10, so that the first plunger 17 can be easily moved inside the first syringe 10.

On the other hand, the first syringe 10 may include a first passage 14 serving as a bypass for fluid flow. The first passage 14 is formed so as to extend longitudinally from the inner circumferential surface of the first syringe 10 to provide a space for fluid flow to the wall of the first syringe 10 with reference to the inner circumferential surface of the first syringe 10 And has an extended groove shape.

The first passage 14 may be integrally formed with the first syringe 10 made of glass. The outer side of the first passage 14 may protrude relative to the outer peripheral surface at a predetermined position on the outer peripheral surface of the first syringe 10. The first passage 14 may be provided in a length corresponding to the length of the packing member 11, 12, 13. Specifically, the first passage 14 may be provided between the first packing member 11 and the second packing member 12. The specific role of the first passage 14 will be described later.

A second syringe 20 may be provided at a predetermined distance from the first syringe 10. The second syringe 20 may be provided in the same shape as the first syringe 10.

That is, the first, second and third packing members 11, 12 and 13 of the first syringe 10, the first passage 14, the first and second chambers 15 Second, third and fourth chambers 21, 22, 23, second passage 24, third and fourth chambers 21, 22, 23, 16 and 16, (25, 26), and a second plunger (27). However, the shape of the second syringe 20 is not limited to this. For example, the second syringe 20 may be formed to be smaller than the diameter of the first syringe 10, 22, 23, passageway 24, chambers 25, 26, and plunger 27 may also be provided correspondingly.

The first syringe 10 and the second syringe 20 can be connected through the connector 30.

For example, the inner space of the first syringe 10 and the inner space of the second syringe 20 may be connected to the inner space of the connector 30, and then connected to each other in the inner space of the nozzle 35.

The internal space of the nozzle 35 coupled to the connector 30 is such that the first solution supplied from the first syringe 10 and the second solution supplied from the second syringe 20 are mixed with each other to perform a chemical reaction Space. In this embodiment, the first solution and the second solution are mixed and discharged in the nozzle 35, and then discharged. However, according to the embodiment, the first solution and the second solution are mixed in the inner space of the connector 30 .

The connector 30 includes a connector body 31, a first connecting portion 32 connected to the first syringe 10, a second connecting portion 33 connected to the second syringe 20, A connector head 34 to which the first solution and the second solution are respectively discharged, and an injection hole 35a (injection hole) for injecting mixed solution, which is coupled to an end of the connector head 34, May be provided. The injection hole 35a is formed at the end of the nozzle 35 and can communicate with the inner space of the nozzle 35. [

The connector body 31 may be a path of movement of a plurality of solutions, that is, a first solution and a second solution.

One side of the connector body 31 may be connected to the first syringe 10 through the first connecting part 32 and the other side may be connected to the second syringe 20 through the second connecting part 33 And the first solution and the second solution transferred through the first connection part 32 and the second connection part 33 can all flow into the inner space of the nozzle 35 through the connector head 34. [ In addition, the first solution and the second solution reaching the inner space of the nozzle 35 may be mixed with each other to become a mixed solution. At this time, a chemical reaction (for example, a crosslinking reaction) may be started. The mixed solution in the inner space of the nozzle 35 can be discharged or injected to the outside of the nozzle 35 through the injection hole 35a of the nozzle 35. [ The injected mixed solution can form a hydrogel by causing a rapid gelation.

The first connection portion 32 and the second connection portion 33 are means for connecting the first syringe 10 and the second syringe 20 to the connector body 31, And the like.

Specifically, the first connection portion 32 includes a first body connection portion 321 provided at one side of the connector body 31, a first syllable connection portion 323 connected to the first syringe 10, And a first packing member fixing portion 322 provided between the first body connecting portion 321 and the first syringe connecting portion 323.

The second connection portion 33 includes a second body connection portion 331 provided on the other side of the connector body 31, a second syringe connection portion 333 connected to the second syringe 20, And a second packing member fixing portion 332 provided between the body connecting portion 331 and the second syringe connecting portion 333. [

The first body connecting portion 321 and the second body connecting portion 331 may include a threaded portion and may be coupled to the connector body 31 through the first body connecting portion 321 and the second body connecting portion 331. However, the method of coupling the first body connecting portion 321 and the second body connecting portion 331 with the connector body 31 is not limited to this, and may be coupled through a separate coupling member, for example.

The internal spaces of the first body connecting portion 321 and the first packing member fixing portion 322 are connected to each other and the internal spaces of the second body connection portion 331 and the second packing member fixing portion 332 are connected to each other It is connected.

The first packing member fixing portion 322 and the second packing member fixing portion 332 may be formed by means of fixing or stopping the first packing member 11 or the fourth packing member 21 moved according to the fluid pressure Lt; / RTI >

The first packing member fixing portion 322 and the second packing member fixing portion 332 are provided with a first protrusion 3221 and a second protrusion 3221 corresponding to the diameters of the first packing member 11 and the fourth packing member 21, A second protrusion 3321 may be provided. At this time, between the first body connecting portion 321 and the first packing member fixing portion 322 and between the second body connecting portion 331 and the second packing member fixing portion 332, A blocking portion 3311 may be provided. The specific structure of the first packing member fixing portion 322 and the second packing member fixing portion 332 will be described later.

The connector 30 may be connected to the first syringe 10 and the second syringe 20 through the first syringe connection portion 323 and the second syringe connection portion 333. [ At this time, the first syringe connection portion 323 and the second syringe connection portion 333 may have a plurality of grooves 3231 and 3331 therein, and the first syringe 10 and the second syringe 20, One side of the first syringe connection portion 323 and the second syringe connection portion 333 may have a diameter larger than the diameter of the plurality of grooves 3231 and 3331.

Specifically, in order to engage the first syringe 10 and the second syringe 20 with the connector 30, heat may be applied to the first syringe connection portion 323 and the second syringe connection portion 333 have. At this time, the first syringe connection portion 323 and the second syringe connection portion 333 may be a thermoplastic material deformed in shape upon application of heat, for example, polypropylene (PP). When heat is applied to the first syringe connection portion 323 and the second syringe connection portion 333, the polymer that has been cured is softened and the first syringe 10 and the second syringe 20 The end of the second syringe connection portion 333 can be inserted into the plurality of grooves 3231 and 3331 of the first syringe connection portion 323 and the second syringe connection portion 333. [ When the first syringe connection portion 323 and the second syringe connection portion 333 are cured again after a predetermined time has passed, the first syringe connection portion 323 and the second syringe connection portion 333 are connected to the plurality of grooves 3231 And 3331, respectively. Therefore, the first syringe connection portion 323 and the second syringe connection portion 333 can be easily combined with the first syringe 10 and the second syringe 20.

On the other hand, the first syringe 10 and the second syringe 20 can be seated on the base 40. The base 40 is for fixing the first syringe 10 and the second syringe 20 and includes a first seat 41 on which the first syringe 10 is seated and a second seat 40 on which the second syringe 10 And a wing-shaped support 43 protruding outwardly of the first and second seating portions 41 and 42. The first and second seating portions 41 and 42 may be fixed to each other. Here, the support 43 can play a role of supporting the pressure of the user's finger so that the plunger 17, 27 can be moved through the plunger holder 50.

The first seating portion 41 and the second seating portion 42 may be provided corresponding to the diameters of the first syringe 10 and the second syringe 20, The fixing portion 43 may be provided on one side of the second seat portion 42 to be positioned at the storage position.

The first plunger 17 and the second plunger 27 of the first syringe 10 and the second syringe 20 can be coupled through the plunger holder 50. [ Specifically, the other side of the first plunger 17 and the second plunger 27, which are exposed to the outside of the first syringe 10 and the second syringe 20, 51 and the second engaging portion 52, respectively. At this time, the first engaging portion 51 and the second engaging portion 52 can be partially opened to a size larger than the diameter of the first plunger 17 and the second plunger 27, The first plunger 17 and the second plunger 27 can be fitted together. Therefore, the user can pressurize the first plunger 17 and the second plunger 27 simultaneously by applying pressure to the plunger holder 50. [

4 (a), the first chamber 15 may be provided with a compound powder, and the second chamber 16 may be provided with a buffer solution. 4 is a side view of the first syringe 10, but the operation of the second syringe 20 is substantially the same as that of the first syringe 10.

When the user applies pressure to the plunger holder 50, the first plunger 17 can push out the third packing member 13. At this time, the third packing member 13 pushes the buffer solution provided in the second chamber 16, whereby the second packing member 12 can also be moved by the moving length of the third packing member 13 have. That is, the volume of the second chamber 16 may be unchanged.

The second packing member 12 moved in accordance with the pressure through the first plunger 17 can be moved to a position corresponding to the first passage 14 (see Fig. 4 (b)). At this time, the first passage 14 can connect the first chamber 15 and the second chamber 16 in space.

As a result, the buffer solution in the second chamber 16, which has been partitioned by the second packing member 12, can be moved to the first chamber 15 through the first passage 14. Thus, the volume of the second chamber 16, which is the space between the second packing member 12 and the third packing member 13, can be gradually reduced, and conversely, the volume of the first chamber 15 gradually decreases Can be increased. When all of the buffer solution in the second chamber 16 is moved to the first chamber 15, the compound powder and the buffer solution provided in the first chamber 15 can be mixed inside the first chamber 15 (c)). At this time, the solution mixed in the first chamber 15 may be the first solution. That is, the first solution may be a mixture of a solid compound powder and a liquid buffer solution.

When all of the buffer solution in the second chamber 16 is moved, the second packing member 12 and the third packing member 13 can be moved in close contact with each other. At this time, along with the movement of the second packing member 12 and the third packing member 13, the first solution in the first chamber 15 can also be moved, (See Fig. 4 (d)) to the inside of the first packing member fixing portion 322 of the first packing member 30.

The first packing member 11 can be fitted to the projection 3221 of the first packing member fixing portion 322 and the first solution inside the first chamber 15 can be fitted into the first packing member fixing portion 322, And can be passed through a plurality of protrusions 3221 spaced apart in the circumferential direction of the inner circumferential surface. At this time, the inner surface of the first packing member fixing portion 322 may be provided with a groove 3222 on the basis of the position of the protrusion 3221 so that the first solution flows smoothly through the groove 3222 Can flow.

A through hole 3212 may be provided at one side of the first body connecting part 321 and a first blocking part 3211 may be provided between the first body connecting part 321 and the first packing member fixing part 322 And the first blocking portion 3211 may be provided with a connection groove 3211a extending from the groove 3222 to the through hole 3212. [ That is, the groove 3222 of the first packing member fixing portion 322 and the connection groove 3211a of the first blocking portion 3211 can be connected to each other. Therefore, the first solution moving along the groove 3222 can be moved to the through hole 3212 along the connection groove 3211a. The first solution discharged through the through hole 3212 is moved to the connector head 34 through the connector body 31 of the connector 30 and then discharged or injected through the injection hole 35a of the nozzle 35. [ .

At this time, substantially the same pressure is applied to the first syringe 10 and the second syringe 20 through the plunger holder 50, so that the discharge of the second solution can be performed by the same process as the discharge of the first solution have.

The first solution and the second solution from the first syringe 10 and the second syringe 20 can be simultaneously discharged to the connector 30 by the operation of the user and mixed at the nozzle 35 just before spraying .

In the prior art, there is a problem that mixing of solutions discharged from a plurality of syringes occurs beforehand, occurs too late, or occurs at an unintended position, unlike the user's intention, but the present invention is not limited to the first packing member 11 And the fourth packing member 21 previously block the discharge of the first solution and the second solution and the first packing member 11 and the fourth packing member 21 are connected to the first packing member fixing portion 322 and the second packing member fixing portion 332 at substantially the same timing so that the problem of clogging of the flow path by mixing the first solution and the second solution in advance can be prevented.

That is, the discharge of the first solution from the first syringe 10 and the discharge of the second solution from the second syringe 20 are performed by the movement of the first packing member 11 and the fourth packing member 21 And the position of each packing member and the volume of the chamber can be set such that the first packing member 11 and the fourth packing member 21 are simultaneously in contact with the first packing member fixing portion 322 and the second packing member 21, And can be set so as to be fitted in the fixing portion 332. [

In addition, not mixed within the connector 30, but mixed and injected at the nozzle 35 immediately before discharge can prevent mixing of a plurality of solutions at an unintended moment, and the mixing of the first syringe 10 and the second syringe 10, The second syringes 20 are injected at the same timing so that a plurality of solutions can be mixed and formed in a single operation.

Also, since conventional products are used after separately performing a process of mixing a plurality of solutions immediately before the injection or after a separate assembly process of mounting the syringe to the applicator, a lot of preparation time is required until the solution is injected, May be low and the possibility of contamination of the solution as the external air is continuously exposed in the step of mixing the solution and assembling the applicator may be inherent. However, since this embodiment is an assembled assembly product, there is an advantage that it can be used immediately after removing the sterilized package from which the assembly product is packaged in the medical field.

FIG. 6 is an exploded perspective view showing another example of the first packing member fixing portion of FIG. 1; FIG.

Referring to Fig. 6, the first syringe 10 may include a first packing member fixing portion 322a having another type of protrusion 3221a. The protrusion 3221a of the first packing member fixing portion 322a may be provided to have a rectangular cross section and may be provided so that the size gradually increases toward the side from which the solution is discharged at the side where the first packing member 11 is inserted . That is, the first packing member fixing portion 322a may have a tapered structure. Specifically, the inner diameter of the first syringe 10 formed through the protrusion 3221a may become smaller toward the side from which the solution is discharged, so that the first packing member 11 is held in the first packing member fixing portion 322a, as shown in Fig. At this time, the inner peripheral surface of the first packing member fixing portion 322a may be provided with a groove 3222a on the basis of the position of the projection 3221a, so that the first solution flows smoothly through the groove 3222a Can flow.

Hereinafter, a sealant syringe assembly according to another embodiment of the present invention will be described with reference to FIG. However, in another embodiment, only the fourth packing member 21 'and the sixth packing member 23' are provided in the third syringe 20 'in comparison with the embodiment of FIG. 1, and one fifth chamber 25 ') are provided. Therefore, differences are mainly described, and explanations and reference numerals of one embodiment are used for the same portions.

7 is a perspective view illustrating a sealant syringe assembly according to another embodiment of the present invention.

Referring to FIG. 7, a third syringe 20 'of the sealant syringe assembly 1' according to another embodiment of the present invention includes a fourth packing member 21 'and a sixth packing member 23' , And a fifth chamber 25 'may be provided between the fourth packing member 21' and the sixth packing member 23 '.

The fifth chamber 25 'is provided with a buffer solution that reacts with the first solution, or a third solution that is a buffer solution in which a compound powder capable of reacting with the compound powder contained in the first solution is dissolved.

When a buffer solution that reacts with the first solution is provided in the fifth chamber 25 ', the first chamber 15 of the first syringe 10 is filled with the highly reactive compound powder and the relatively reactive A mixture of these low compound powders can be provided. This mixture can be mixed with the buffer solution provided in the second chamber 16 of the first syringe 10 and discharged and reacted with the buffer solution provided from the third syringe 20 '.

In the case where a compound powder capable of reacting with the compound powder contained in the first solution is provided in the fifth chamber 25 ', the compound powder provided in the fifth chamber 25' It may be a compound powder which is relatively less reactive than the powder. The third solution containing the compound powder having high reactivity and the compound powder having low reactivity is discharged from the first syringe 10 and the third syringe 20 'and reacted with each other.

When the third syringe 20 'receives pressure through the plunger 27, the third solution may be discharged to the connector 30 and mixed with the first solution.

At this time, the discharge of the first solution from the first syringe 10 and the discharge of the third solution from the third syringe 20 'are performed by the first packing member 11 and the fourth packing member 21' And the position of each packing member and the volume of the chamber can be synchronized by the movement of the first packing member fixing portion 322 and the second packing member fixing portion 21 ' 2 packing member fixing portion 332. [0157] For example, the inner diameter of the third syringe 20 'may be adjusted to match the speed of the first solution and the third solution. Thus, the first solution and the third solution can be mixed simultaneously in the connector 30.

Although the embodiments of the present invention have been described with reference to specific embodiments thereof, it should be understood that the present invention is not limited thereto, and may be construed as having the broadest scope according to the basic idea disclosed herein do. Skilled artisans may implement the pattern of features that have not been explicitly described in combination, substitution of the disclosed embodiments, but which, too, do not depart from the scope of the present invention. It will be apparent to those skilled in the art that various changes and modifications may be readily made without departing from the spirit and scope of the invention as defined by the appended claims.

1: sealant syringe assembly
10: 1st Syringe 20: 2nd Syringe
30: connector 40: base
50: Plunger holder

Claims (12)

A first syringe including a plurality of chambers and discharging a first solution made by mixing a buffer solution of one chamber and a compound powder of the other chamber;
A third syringe containing one chamber and discharging a third solution capable of reacting with the first solution;
A base on which the first syringe and the third syringe are seated; And
And a connector for connecting the first syringe and the third syringe to mix and discharge the first solution and the third solution,
A compound powder having lower reactivity than the first solution is contained in the other chamber of the first syringe or inside the chamber of the third syringe,
The first solution and the third solution react to change the shear storage modulus so that the shear storage modulus exceeds the shear loss modulus,
The first saddle-
Three packing members provided inside the first syringe;
A passage provided in the inner circumferential surface of the first syringe; And
And a plunger for providing pressure to one of the packing members
Sealant syringe assembly.
The method according to claim 1,
Wherein the chemical reaction upon mixing the first solution and the third solution occurs immediately upon mixing.
The method according to claim 1,
Wherein the compound powder is provided as a synthetic polymer of any one of poly ethylene glycol (PEG), poly vinyl alcohol (PVA), and poly ethylene imine (PEI).
The method according to claim 1,
The compound powder is provided as a natural polymer of any one of chitosan, hyaluronic acid, alginate, gelatin, dextran, alpha glucan, betaglucan, chondroitin sulfate and poly glutamic acid.
The method according to claim 1,
The buffer solution may be distilled water or an aqueous solution of sodium chloride, potassium chloride, NaH2PO4, Na2HPO4, KH2PO4, Na2CO3, HCl, , MES, Tris, HEPES dissolved in an aqueous solution.
delete 6. The method according to any one of claims 1 to 5,
The first syringe and the third syringe each include a first packing member and a fourth packing member disposed closest to the connector,
Wherein the first packing member and the fourth packing member block movement of the first solution and the third solution so that the first solution and the third solution can be discharged to the connector at the same time, respectively.
8. The method of claim 7,
Wherein the first solution and the third solution are formed such that after the first packing member and the fourth packing member are respectively fitted to the packing member fixing portions, the first packing member and the fourth packing member and each of the packing member fixing portions And is moved to the connector through a groove formed between the inner circumferential surfaces.
6. The method according to any one of claims 1 to 5,
The first syringe is spatially connected to each other through the passage when pressure is applied to the packing member through the plunger, and the buffer solution flows through the passage to be mixed with the compound powder, Syringe assembly.
A first syringe including a plurality of chambers and discharging a first solution made by mixing a buffer solution of one chamber and a compound powder of the other chamber;
A third syringe containing one chamber and discharging a third solution capable of reacting with the first solution;
A base on which the first syringe and the third syringe are seated; And
And a connector for connecting the first syringe and the third syringe to mix and discharge the first solution and the third solution,
A compound powder having lower reactivity than the first solution is contained in the other chamber of the first syringe or inside the chamber of the third syringe,
The first solution and the third solution react to change the shear storage modulus so that the shear storage modulus exceeds the shear loss modulus,
Wherein the connector comprises:
A connector body serving as a movement path of the first solution and the third solution;
A first connection part connected to the first syringe;
A second connection part connected to the third syringe;
A connector head in which the first solution and the third solution are respectively discharged; And
And a nozzle coupled to an end of the connector head, the nozzle having an internal space for solution mixing and an injection hole,
Wherein the first connection portion and the second connection portion each include:
A body connector connected to the connector body;
A syringe connection portion connected to the first syringe or the third syringe;
And a packing member fixing portion provided between the body connection portion and the syringe connection portion and provided with a plurality of projections therein,
Wherein one of the packing members is fitted to the projection and the first solution or the third solution moves through the plurality of projections and is discharged through the nozzle
Sealant syringe assembly.
delete 6. The method according to any one of claims 1 to 5,
Wherein the plunger of the first syringe and the third syringe is coupled to the plunger holder to simultaneously apply pressure to the first syringe and the packing member of the third syringe.

Images